Journal ArticleJ Clin Epidemiol · February 2026
OBJECTIVES: The current literature lacks an established and adoptable definition of "racial health equity." This study aimed to catalog and evaluate, via thematic analyses, definitions and terminology related to racial health equity across the specific stu ...
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Journal ArticleAlzheimers Dement · January 2026
INTRODUCTION: Black American men are underrepresented in Alzheimer's disease and Alzheimer's disease related dementias (AD/ADRD) research. This article aims to provide a framework for recruiting Black men in biomedical research, particularly for AD/ADRD ca ...
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Journal ArticleBMJ Open · November 28, 2025
INTRODUCTION: This scoping review will evaluate and synthesise what is known about the impact of structural and social determinants of health on neurodegeneration among adults of African American or Black (AAB) racial identity with a history of traumatic b ...
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Journal ArticleJ Med Internet Res · July 23, 2025
BACKGROUND: The websites of prominent public health and health care organizations play pivotal roles in ensuring access to quality health information, including information guiding health equity. Several initiatives have been developed in the United States ...
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Journal ArticleBrain Struct Funct · June 8, 2025
This collective eulogy by colleagues, co-authors and friends is a tribute to the work and life of Rudolf Nieuwenhuys. 'Neurofascination' is an apt label for his scholarly life in the sciences from the start in 1955 until his last days in 2024. In addition, ...
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Journal ArticleAlzheimers Dement · May 2025
As the rates of Alzheimer's disease (AD) and AD and related dementias (ADRD) in the United States steadily rise, so too does the demand for informal caregiving. Research on AD/ADRD caregiving highlights the associated risk of adverse health outcomes and lo ...
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Journal ArticleAlzheimer S and Dementia Translational Research and Clinical Interventions · April 1, 2025
INTRODUCTION: Many longitudinal Alzheimer's disease studies fail to retain Black American adults once enrolled. This limits the generalizability of research findings. METHODS: The Community-Engaged Digital Alzheimer's Research (CEDAR) study developed digit ...
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Journal ArticleJ Aging Health · March 2025
The objective of this study was to determine if racial differences exist between older Non-Hispanic Black (NHB) and White (NHW) men in incident dementia over 11 years (2011-2022) in the National Health and Aging Trends Study (NHATS). The analytic sample in ...
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Journal ArticleBrain Communications · January 1, 2025
Repetitive head impacts are common in contact and collision sports and are linked to structural brain changes and an elevated risk of neurodegenerative diseases such as Chronic Traumatic Encephalopathy. Identifying early in vivo structural markers remains ...
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Journal ArticleJ Clin Epidemiol · December 2024
OBJECTIVES: To systematically evaluate definitions of "racial health equity" (RHE) and related terms within health-related academic literature. STUDY DESIGN AND SETTING: We systematically evaluated definitions of RHE and related terms within health-related ...
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Journal ArticleBrain Inj · September 18, 2024
OBJECTIVE: Considering that diagnostic decisions about mTBI are often predicated on clinical symptom criteria, it is imperative to determine which initial presentation features of mTBI have prognostic significance for identifying those at high risk for lon ...
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Journal ArticleNeurol Clin Pract · April 2024
BACKGROUND AND OBJECTIVES: Obstructive sleep apnea (SA) is common in older men and a contributor to negative cognitive, psychiatric, and brain health outcomes. Little is known about SA in those who played contact sports and are at increased risk of neurode ...
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Journal ArticleAlzheimers Dement · March 2024
INTRODUCTION: Tau is a key pathology in chronic traumatic encephalopathy (CTE). Here, we report our findings in tau positron emission tomography (PET) measurements from the DIAGNOSE CTE Research Project. METHOD: We compare flortaucipir PET measures from 10 ...
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Journal ArticleAlzheimers Dement · February 2024
BACKGROUND: In Alzheimer's disease (AD) research, subjective reports of cognitive and functional decline from participant-study partner dyads is an efficient method of assessing cognitive impairment and clinical progression. METHODS: Demographics and subje ...
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Journal ArticleFront Psychiatry · 2024
BACKGROUND: The subgenual Anterior Cingulate Cortex (sgACC), as a part of the Anterior Cingulate Cortex and the limbic system plays a crucial role in mood regulation. Previous structural and functional brain imaging studies of the sgACC have revealed alter ...
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Journal ArticleFront Psychiatry · 2024
BACKGROUND: The basolateral complex of the amygdala is a crucial neurobiological site for Pavlovian conditioning. Investigations into volumetric alterations of the basolateral amygdala in individuals with major depressive disorder (MDD) have yielded confli ...
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Journal ArticleSyst Rev · September 30, 2023
BACKGROUND: In the USA, access to quality healthcare varies greatly across racial and ethnic groups, resulting in significant health disparities. A new term, "racial health equity" (RHE), is increasingly reported in the medical literature, but there is cur ...
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Journal ArticleAlzheimers Dement · July 2023
INTRODUCTION: The projected growth of Alzheimer's disease (AD) and AD-related dementia (ADRD) cases by midcentury has expanded the research field and impelled new lines of inquiry into structural and social determinants of health (S/SDOH) as fundamental dr ...
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Journal ArticleJ Relig Health · April 2023
This study explores the relationship between religious service attendance, social ties, and health among former NFL players, a population with relatively high levels of religious attendance who endure physically demanding occupations. Research shows that f ...
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Journal ArticleAlzheimers Res Ther · January 3, 2023
BACKGROUND: Patterns of cognitive impairment in former American football players are uncertain because objective neuropsychological data are lacking. This study characterized the neuropsychological test performance of former college and professional footba ...
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Journal ArticleJ Prev Alzheimers Dis · 2023
BACKGROUND: Although Black/African American older adults bear significant inequities in prevalence, incidence, and outcomes of Alzheimer's disease and related dementias, they are profoundly under-included in Alzheimer's Disease research. Community-Engaged ...
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Journal ArticleJ Prev Alzheimers Dis · 2023
BACKGROUND: Failure of Alzheimer's disease and related diseases (ADRD) research studies to include and engage Black participants is a major issue, which limits the impact and generalizability of research findings. Little is known about participation of Bla ...
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Journal ArticleEur J Nucl Med Mol Imaging · January 2023
PURPOSE: Flourine-18-flortaucipir tau positron emission tomography (PET) was developed for the detection for Alzheimer's disease. Human imaging studies have begun to investigate its use in chronic traumatic encephalopathy (CTE). Flortaucipir-PET to autopsy ...
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Journal ArticleJ Neurol · September 2022
The objective of this systematic review is to synthesize the relevant literature published after 2016 to ascertain the current landscape of science that relates mild traumatic brain injury (mTBI) to the onset of Alzheimer's disease and related dementias (A ...
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Journal ArticleNeurology · January 4, 2022
Objective – Young American athletes, at risk of sport-related concussion (SRC), represent many races; however, it is unknown how race influences the experience and outcome of SRC. Our objective was to compare White and Black athletes' recovery and subjecti ...
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Journal ArticleChronobiol Int · September 2021
Previous studies have shown individuals with evening chronotype to have a greater likelihood for depression (self-reported and clinical ratings), especially in young adults. However, the mechanisms for this relationship remain unknown. Low levels of social ...
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Journal ArticleNeuroimage · August 15, 2021
Cerebral blood volume (CBV) has been shown to be a robust and important physiological parameter for quantitative interpretation of functional (f)MRI, capable of delivering highly localized mapping of neural activity. Indeed, with recent advances in ultra-h ...
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Journal ArticleAlzheimers Res Ther · August 12, 2021
BACKGROUND: Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease that has been neuropathologically diagnosed in brain donors exposed to repetitive head impacts, including boxers and American football, soccer, ice hockey, and rugby players. ...
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Journal ArticleJAMA Neurol · March 1, 2021
IMPORTANCE: In the US, dementia risk is higher in non-Hispanic Black individuals than in non-Hispanic White individuals. To evaluate progress toward reducing such disparities, tracking secular trends in racial disparities in dementia prevalence is essentia ...
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Journal ArticleJ Am Coll Health · January 2021
Examine associations between a range of sleep problems and academic performance in a national sample of collegiate athletes. Participants: Data were obtained from the National College Health Assessment of US college/university students from 2011-2014 (N = ...
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Journal ArticleNeurosci Biobehav Rev · September 2020
A comprehensive understanding of the basic molecular and cellular mechanisms of the brain is important for the scientific discovery of root causes, risk and protective factors for mental disorders in global mental health. Systematic research in cultural ne ...
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Journal ArticleElife · January 8, 2020
In our environment, our senses are bombarded with a myriad of signals, only a subset of which is relevant for our goals. Using sub-millimeter-resolution fMRI at 7T, we resolved BOLD-response and activation patterns across cortical depth in early sensory co ...
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Journal ArticleAm J Mens Health · 2020
Over the past decade, media outlets have drawn attention to some of the health consequences of playing in the National Football League (NFL), including how wear-and-tear and injuries accumulated during athletes' playing years can affect their physical, emo ...
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Journal ArticleInnov Aging · 2020
BACKGROUND AND OBJECTIVES: Sleep difficulties are common among older adults and are associated with cognitive decline. We used data from a large, nationally representative longitudinal survey of adults aged older than 50 in the United States to examine the ...
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Journal ArticleProc Biol Sci · April 24, 2019
Many species use touching for reinforcing social structures, and particularly, non-human primates use social grooming for managing their social networks. However, it is still unclear how social touch contributes to the maintenance and reinforcement of huma ...
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Journal ArticleAm J Mens Health · 2019
The objective of this study was to analyze data from the National Football League Player Care Foundation Study of Retired NFL Players to understand potential risks for depressive symptoms in former athletes by investigating the relationship between pain an ...
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Journal ArticleFront Neural Circuits · 2019
Histological studies of myelin-stained sectioned cadaver brain and in vivo myelin-weighted magnetic resonance imaging (MRI) show that the cerebral cortex is organized into cortical areas with generally well-defined boundaries, which have consistent interna ...
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Journal ArticleNeuroimage · May 15, 2018
The neuromatrix, or "pain matrix", is a network of cortical brain areas which is activated by noxious as well as salient somatosensory stimulation. This has been studied in mice and humans using blood oxygenation level-dependent (BOLD) fMRI. Here we demons ...
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Journal ArticleJ Alzheimers Dis · 2018
BACKGROUND: PET imaging is an established technique to detect cerebral amyloid-β (Aβ) plaques in vivo. Some preclinical and postmortem data report an accumulation of redox-active iron near Aβ plaques. Quantitative susceptibility mapping (QSM) at high-field ...
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Journal ArticleCereb Cortex · September 1, 2017
The reciprocal cortico-cerebellar loops that underlie cerebellar contributions to motor and cognitive behavior form one of the largest systems in the primate brain. Work with non-human primates has shown that the dentate nucleus, the major output nucleus o ...
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Journal ArticleBrain Struct Funct · August 2017
The aging brain undergoes several anatomical changes that can be measured with Magnetic Resonance Imaging (MRI). Early studies using lower field strengths have assessed changes in tissue properties mainly qualitatively, using [Formula: see text]- or [Formu ...
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Journal ArticleBr J Radiol · May 2017
OBJECTIVE: A fine structure of the corpus callosum (CC), consisting of radial lines, is seen in historical anatomical atlases as far back as that of Vicq d'Azyr (1786). This study examines a similar pattern observed in vivo using high-resolution MR images ...
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Journal ArticleEur Arch Psychiatry Clin Neurosci · March 2017
The habenula is a paired epithalamic structure involved in the pathogenesis of major depressive disorder (MDD). Evidence comes from its impact on the regulation of serotonergic and dopaminergic neurons, the role in emotional processing and studies on anima ...
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Journal ArticleBrain Inj · 2017
PRIMARY OBJECTIVE: To preliminarily explore parents' health literacy and knowledge of youth sport league rules involving concussion education and training, and return-to-play protocols. RESEARCH DESIGN AND METHODS: This study was guided by the Knowledge, A ...
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Journal ArticleNMR Biomed · September 2016
The increased availability of ultra-high-field (UHF) MRI has led to its application in a wide range of neuroimaging studies, which are showing promise in transforming fundamental approaches to human neuroscience. This review presents recent work on structu ...
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Journal ArticleCereb Cortex · July 2016
Trance is an absorptive state of consciousness characterized by narrowed awareness of external surroundings and has long been used-for example, by shamans-to gain insight. Shamans across cultures often induce trance by listening to rhythmic drumming. Using ...
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Journal ArticleBrain Struct Funct · April 2016
A key aspect of optimal behavior is the ability to predict what will come next. To achieve this, we must have a fairly good idea of the probability of occurrence of possible outcomes. This is based both on prior knowledge about a particular or similar situ ...
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Journal ArticleHum Brain Mapp · October 2015
Several prominent neurocomputational models predict that an increase of choice alternatives is modulated by increased activity in the subthalamic nucleus (STN). In turn, increased STN activity allows prolonged accumulation of information. At the same time, ...
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Journal ArticleBrain · August 2015
Musical memory is considered to be partly independent from other memory systems. In Alzheimer's disease and different types of dementia, musical memory is surprisingly robust, and likewise for brain lesions affecting other kinds of memory. However, the mec ...
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Journal ArticleMagn Reson Med · August 2015
PURPOSE: Yang et al. proposed an MRI technique for the simultaneous acquisition of cerebral blood volume (CBV), cerebral blood flow (CBF), and blood oxygenation level-dependent (BOLD)-weighted MRI signals (9). The purpose of this study was to develop modif ...
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Journal ArticleNeuroimage · July 1, 2015
This work presents a novel approach for modelling laminar myelin patterns in the human cortex in brain MR images on the basis of known cytoarchitecture. For the first time, it is possible to estimate intracortical contrast visible in quantitative ultra-hig ...
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Journal ArticleMAGMA · February 2015
OBJECTIVE: To identify a shielding material compatible with optical head-motion tracking for prospective motion correction and which minimizes radio frequency (RF) radiation losses at 7 T without sacrificing line-of-sight to an imaging target. MATERIALS AN ...
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Journal ArticleGlob Pediatr Health · 2015
Objective. To understand the relationships between participation in different types of leisure time sport activity and adolescent obesity, and how those relationships might differ based on race, gender, and household income. Methods. Data consisted of 6667 ...
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Journal ArticleBrain Struct Funct · 2015
In this paper, we describe a novel processing strategy for the spatial normalization of ultrahigh resolution magnetic resonance imaging (MRI) data of small ex vivo samples into MNI standard space. We present a multistage scanning and registration method fo ...
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Journal ArticleMagn Reson Med · November 2014
PURPOSE: Specific absorption rate is a serious problem at high field strengths, especially for sequences involving many high power radiofrequency pulses, such as turbo spin echo (TSE). GRASE (gradient and spin echo) may overcome this problem by omitting a ...
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Journal ArticleHum Brain Mapp · September 2014
The subthalamic nucleus (STN) is an important node of the cortico-basal ganglia network and the main target of deep brain stimulation (DBS) in Parkinson's disease. Histological studies have revealed an inhomogeneous iron distribution within the STN, which ...
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Journal ArticleNeuroimage · July 1, 2014
Functional magnetic resonance imaging (MRI) data are usually registered into standard anatomical space. However, standard atlases, such as LPBA40, the Harvard-Oxford atlas, FreeSurfer, and the Jülich cytoarchitectonic maps all lack important detailed infor ...
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Journal ArticleNeuroimage · June 2014
Improvements in the spatial resolution of structural and functional MRI are beginning to enable analysis of intracortical structures such as heavily myelinated layers in 3D, a prerequisite for in-vivo parcellation of individual human brains. This parcellat ...
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Journal ArticleInvest Radiol · May 2014
OBJECTIVES: The aims of this study were to investigate the subjective discomfort and sensory side effects during ultrahigh field (UHF) magnetic resonance imaging (MRI) examinations in a large-scale study and to evaluate differences between magnetic resonan ...
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Journal ArticleSci Data · 2014
Structural brain data is key for the understanding of brain function and networks, i.e., connectomics. Here we present data sets available from the 'atlasing of the basal ganglia (ATAG)' project, which provides ultra-high resolution 7 Tesla (T) magnetic re ...
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Journal ArticleNeuroimage · January 1, 2014
OBJECTIVE: We aimed to test the hypothesis that slice-by-slice prospective motion correction at 7T using an optical tracking system reduces the rate of false positive activations in an fMRI group study with a paradigm that involves task-correlated motion. ...
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Journal ArticleFront Hum Neurosci · 2014
Functional magnetic resonance imaging (fMRI) is the workhorse of imaging-based human cognitive neuroscience. The use of fMRI is ever-increasing; within the last 4 years more fMRI studies have been published than in the previous 17 years. This large body of ...
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Journal ArticleFront Neurosci · 2014
Although ultra-high-field fMRI at field strengths of 7T or above provides substantial gains in BOLD contrast-to-noise ratio, when very high-resolution fMRI is required such gains are inevitably reduced. The improvement in sensitivity provided by multivaria ...
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Journal ArticleClin Pediatr (Phila) · October 2013
OBJECTIVE: American football is one of the most common high school sports in the United States. We examine obesity among high school football players, and variations based on positions, team division, and team success. PATIENTS AND METHODS: We used 2 data ...
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Conference2013 IEEE MTT-S INTERNATIONAL MICROWAVE WORKSHOP SERIES ON RF AND WIRELESS TECHNOLOGIES FOR BIOMEDICAL AND HEALTHCARE APPLICATIONS (IMWS-BIO) · 2013Link to itemCite
Conference2013 IEEE MTT-S INTERNATIONAL MICROWAVE WORKSHOP SERIES ON RF AND WIRELESS TECHNOLOGIES FOR BIOMEDICAL AND HEALTHCARE APPLICATIONS (IMWS-BIO) · 2013Link to itemCite
Journal ArticleFront Hum Neurosci · 2013
The habenula is a small but important nucleus located next to the third ventricle in front of the pineal body. It helps to control the human reward system and is considered to play a key role in emotion, showing increased activation in major depressive dis ...
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ConferenceMed Image Comput Comput Assist Interv · 2013
A conclusive mapping of myeloarchitecture (myelin patterns) onto the cortical sheet and, thus, a corresponding mapping to cytoarchitecture (cell configuration) does not exist today. In this paper we present a generative model which can predict, on the basi ...
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Journal ArticleAnthropological Theory · March 2012
The conceptual foundations and ontology of cognitive neuroscience are rarely analysed in cross-cultural perspective, although they are manifestly the outcome of historical currents in specifically Western psychological science. How robust such conc ...
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Journal ArticleCase Studies in Sport Management · January 2012
Aaron Kelly, a highly respected college sport consultant, is charged with the task of presenting a new model of intercollegiate athletic administration to a panel of leaders in the field. Coincidence and research led him to a successful National Ju ...
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Journal ArticlePLoS One · 2011
Recently, we demonstrated using functional magnetic resonance imaging (fMRI) that the outcome of free decisions can be decoded from brain activity several seconds before reaching conscious awareness. Activity patterns in anterior frontopolar cortex (BA 10) ...
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Journal ArticleProc Natl Acad Sci U S A · September 7, 2010
When people make decisions they often face opposing demands for response speed and response accuracy, a process likely mediated by response thresholds. According to the striatal hypothesis, people decrease response thresholds by increasing activation from ...
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Journal ArticleMagn Reson Med · August 2010
We have discovered a simple and highly robust method for removal of chemical shift artifact in spin-echo MR images, which simultaneously decreases the radiofrequency power deposition (specific absorption rate). The method is demonstrated in spin-echo echo- ...
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Journal ArticleMagn Reson Med · July 2010
A good spatial resolution is essential for high precision segmentations of small structures in magnetic resonance images. However, any increase in the spatial resolution results in a decrease of the signal-to-noise ratio (SNR). In this article, this proble ...
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Journal ArticleMagn Reson Med · July 2010
Anatomical MRI studies at 7T have demonstrated the ability to provide high-quality images of human tissue in vivo. However, diffusion-weighted imaging at 7T is limited by the increased level of artifact associated with standard, single-shot, echo-planar im ...
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Journal ArticleSoc Cogn Affect Neurosci · June 2010
In this article, we argue that a combined anthropology/neuroscience field of enquiry can make a significant and distinctive contribution to the study of the relationship between culture and the brain. This field, which can appropriately be termed as neuroa ...
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Journal ArticleCereb Cortex · June 2010
Low-frequency fluctuations (LFFs) are a major source of variation in fMRI data. This has been established in numerous experiments-particularly in the resting state. Here we investigate LFFs in a task-dependent setting. We hypothesized that LFFs may contain ...
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Journal ArticlePLoS One · April 27, 2010
Functional magnetic resonance data acquired in a task-absent condition ("resting state") require new data analysis techniques that do not depend on an activation model. In this work, we introduce an alternative assumption- and parameter-free method based o ...
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Journal ArticleJ Magn Reson · September 2009
To accelerate the analysis of a multi-element MRI coil, a two-way link is used between radiofrequency (RF) circuit and 3-D electromagnetic (EM) simulation tools. In this configuration, only one 3-D EM simulation is required to investigate the coil performa ...
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Journal ArticleCurr Biol · April 14, 2009
It has long been debated which aspects of music perception are universal and which are developed only after exposure to a specific musical culture. Here, we report a crosscultural study with participants from a native African population (Mafa) and Western ...
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Chapter · 2009
Neuroanthropology is a new field of research that can make two distinctive contributions to our understanding of the brain-culture nexus. The first contribution has to do with the question of how socially shared meanings and practices are reflected in brai ...
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Journal ArticleANZ J Surg · September 2008
BACKGROUND: Accurate operation record keeping is an important element of risk management. Handwritten surgical notes are often produced as evidence in medico-legal malpractice cases and incomplete and illegible notes may be a source of weakness in a surgeo ...
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Journal ArticleNeuroscience · November 3, 2006
T-type calcium channel isoforms are expressed in a multitude of tissues and have a key role in a variety of physiological processes. To fully appreciate the physiological role of distinct channel isoforms it is essential to determine their kinetic properti ...
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Journal ArticleJ Comp Physiol A Neuroethol Sens Neural Behav Physiol · June 2006
Potassium channels are one of the fundamental requirements for the generation of action potentials in the nervous system, and their characteristics shape the output of neurons in response to synaptic input. We review here the distribution and function of a ...
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Journal ArticleProc Natl Acad Sci U S A · April 4, 2006
T-type calcium channels are thought to transform neuronal output to a burst mode by generating low voltage-activated (LVA) calcium currents and rebound burst discharge. In this study we assess the expression pattern of the three different T-type channel is ...
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Journal ArticleJ Biol Chem · March 10, 2006
Plasma membrane Na+/Ca2+-exchangers play a predominant role in Ca2+ extrusion in brain. Neurons express several different Na+/Ca2+-exchangers belonging to both the K+-independent NCX family and the K+-dependent NCKX family. The unique contributions of each ...
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Journal ArticleJ Neurosci · December 14, 2005
Pyramidal neurons of the electrosensory lateral line lobe (ELL) of Apteronotus leptorhynchus express Kv3-type voltage-gated potassium channels that give rise to high-threshold currents at the somatic and dendritic levels. Two members of the Kv3 channel fam ...
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Journal ArticleJ Neurophysiol · December 2005
Many central neurons support active dendritic spike backpropagation mediated by voltage-gated currents. Active spikes in dendrites have been shown capable of providing feedback to the soma to influence somatic excitability and firing dynamics through a dep ...
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Journal ArticleJ Neurosci · November 23, 2005
The modification of first-spike latencies by low-threshold and inactivating K+ currents (IA) have important implications in neuronal coding and synaptic integration. To date, cells in which first-spike latency characteristics have been analyzed have shown ...
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Journal ArticleJ Neurosci · October 26, 2005
Multiplicative gain control is a vital component of many theoretical analyses of neural computations, conferring the ability to scale neuronal firing rate in response to synaptic inputs. Many theories of gain control in single cells have used precisely bal ...
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Journal ArticleJ Physiol · September 15, 2005
Cerebellar Purkinje cells integrate multimodal afferent inputs and, as the only projection neurones of the cerebellar cortex, are key to the coordination of a variety of motor- and learning-related behaviours. In the neonatal rat the cerebellum is undevelo ...
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Journal ArticleJ Neurosci · February 9, 2005
Purkinje cells (PCs) generate the sole output of the cerebellar cortex and govern the timing of action potential discharge from neurons of the deep cerebellar nuclei (DCN). Here, we examine how voltage-gated Kv1 K+ channels shape intrinsically generated an ...
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Journal ArticleJ Neurosci · January 12, 2005
High-frequency firing neurons are found in numerous central systems, including the auditory brainstem, thalamus, hippocampus, and neocortex. The kinetics of high-threshold K+ currents (IK(HT)) from the Kv3 subfamily has led to the proposal that these chann ...
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Journal ArticleEur J Neurosci · August 2004
The ability of cells to generate an appropriate spike output depends on a balance between membrane depolarizations and the repolarizing actions of K(+) currents. The high-voltage-activated Kv3 class of K(+) channels repolarizes Na(+) spikes to maintain hig ...
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Journal ArticleJ Comp Neurol · May 17, 2004
The vitamin biotin is an endogenous molecule that acts as an important cofactor for several carboxylases in the citric acid cycle. Disorders of biotin metabolism produce neurological symptoms that range from ataxia to sensory loss, suggesting the presence ...
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Journal ArticlePflugers Arch · May 2004
The extracellular matrix of adult neural tissue contains chondroitin sulphated proteogylcans that form a dense peri-neuronal net surrounding the cell body and proximal dendrites of many neuronal classes. Development of the peri-neuronal net beyond approxim ...
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Journal ArticleJ Biol Chem · October 17, 2003
Kv3.3 K+ channels are believed to incorporate an NH2-terminal domain to produce an intermediate rate of inactivation relative to the fast inactivating K+ channels Kv3.4 and Kv1.4. The rate of Kv3.3 inactivation has, however, been difficult to establish giv ...
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Journal ArticleJ Neurosci · February 15, 2003
Na+-dependent spikes initiate in the soma or axon hillock region and actively backpropagate into the dendritic arbor of many central neurons. Inward currents underlying spike discharge are offset by outward K+ currents that repolarize a spike and establish ...
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Journal ArticleJ Neurophysiol · January 2003
The estimation and detection of stimuli by sensory neurons is affected by factors that govern a transition from tonic to burst mode and the frequency characteristics of burst output. Pyramidal cells in the electrosensory lobe of weakly electric fish genera ...
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Journal ArticleJ Neurophysiol · October 2001
Pyramidal cells of the electrosensory lateral line lobe (ELL) of the weakly electric fish Apteronotus leptorhynchus have been shown to produce oscillatory burst discharge in the gamma-frequency range (20-80 Hz) in response to constant depolarizing stimuli. ...
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Journal ArticleJ Neurosci · January 1, 2001
Voltage-gated ion channels localized to dendritic membranes can shape signal processing in central neurons. This study describes the distribution and functional role of a high voltage-activating K(+) channel in the electrosensory lobe (ELL) of an apteronot ...
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Journal ArticleJ Neurophysiol · September 2000
Backpropagating dendritic Na(+) spikes generate a depolarizing afterpotential (DAP) at the soma of pyramidal cells in the electrosensory lateral line lobe (ELL) of weakly electric fish. Repetitive spike discharge is associated with a progressive depolarizi ...
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Journal ArticleJournal of Applied Meteorology · March 1998
AbstractThe potential impact of the increase in irrigated areas in North America during the past 100 years on summer rainfall associated with medium- to large-scale precipitation systems is evaluated conceptually and by sev ...
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Journal ArticleJ Neurophysiol · October 1997
The electrosensory lateral line lobe (ELL) of the South American gymnotiform fish Apteronotus leptorhynchus has a laminar structure: electroreceptor afferents terminate ventrally whereas feedback input distributes to a superficial molecular layer containin ...
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Journal ArticleJ Comp Neurol · September 22, 1997
A modification of the tissue printing technique was used to acutely isolate and culture cells from the electrosensory lateral line lobe (ELL), corpus cerebelli (CCb), and eminentia granularis pars posterior (EGp) of the adult weakly electric fish, Apterono ...
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Journal ArticleJ Neurophysiol · October 1996
1. Three parallel maps of the distribution of tuberous electroreceptor inputs are found in the medullary electrosensory lateral line lobe (ELL) of weakly electric fish. Pyramidal cells in each map are known to respond differentially to the frequency of amp ...
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Journal ArticleJ Comp Neurol · October 23, 1995
Previous studies have indicated that nitric oxide, a labile freely diffusible biological messenger synthesized by nitric oxide synthase, may modulate light transduction and signal transmission in the retina. In the present work, the large size of retinal c ...
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Journal ArticleJ Comp Neurol · July 31, 1995
The present study established the morphological and immunocytochemical criteria necessary to identify neuronal and nonneuronal cells after dissociating select regions of the medullary electrosensory lateral line lobe of adult weakly electric fish (Apterono ...
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Journal ArticleJ Neurosci Methods · January 1995
Acute isolation of vertebrate neurons has been used extensively to characterize membrane properties in the absence of circuit connections or extensive dendritic arborizations. We describe a technique that allows cells to be dissociated from anatomically de ...
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Journal ArticleJ Neurosci · November 1994
Immunocytochemical and electrophysiological techniques were used to localize TTX-sensitive sodium channels (NaChs) over the soma-dendritic axis of basilar and nonbasilar pyramidal cells of the electrosensory lateral line lobe (ELL) of weakly electric fish ...
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Journal ArticleNeuron · August 1994
Subcellular compartments in the outer retina of the larval tiger salamander were identified as likely sites of production of nitric oxide (NO), a recently recognized intercellular messenger. NADPH diaphorase histochemistry and NO synthase immunocytochemist ...
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Journal ArticleNeuroscience · April 1993
Small all-or-none pre-potentials have been shown under some conditions to underlie antidromic and orthodromic spike discharge in somatic recordings of hippocampal pyramidal neurons [Andersen P. and Lomo T. (1966) Expl Brain Res. 2, 247-260; Kandel E. R. et ...
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Journal ArticleJ Neurosci · July 1991
Early electrophysiological studies in the mammalian hippocampus reported that orthodromic depolarization of pyramidal cells evoked action potential discharge (presumed Na+ dependent) both at the axon hillock and at one or more sites in the dendritic arbori ...
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Journal ArticleNeuroscience · 1991
The relationship between orthodromic extracellular field potentials and intradendritic depolarizations in apical dendrites of CA1 pyramidal neurons was investigated using the in vitro slice preparation of rat hippocampus. Orthodromic synaptic field potenti ...
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Journal ArticleJ Neurophysiol · December 1989
1. The role of tetrodotoxin (TTX)-sensitive (Na+) channels in the generation of antidromic and orthodromic field potentials of the CA1 pyramidal cell population was examined by local application of TTX in the in vitro rat hippocampal slice preparation. 2. ...
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Journal ArticleJ Neurophysiol · November 1987
1. The site of origin of evoked action-potential discharge in hippocampal CA1 pyramidal neurons was investigated using the in vitro rat hippocampal slice preparation. 2. Action-potential discharge in pyramidal cells was evoked by stimulation of efferent py ...
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Journal ArticleJ Med Vet Mycol · April 1986
The anti-dermatophyte agent tolnaftate was compared with the allylamine antifungal compounds naftifine and terbinafine. Tolnaftate was shown to inhibit sterol biosynthesis at the level of squalene epoxidation and squalene was shown to accumulate in dermato ...
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Journal ArticleBrain Res · March 5, 1984
The influence of extracellular fields on the transmembrane potential (TMP) of CA1 pyramidal neurons was investigated following both ortho- and antidromic stimulation in the in vitro hippocampal slice preparation. A short latency negative deflection on the ...
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Journal ArticleExp Brain Res · 1984
The contribution of ephaptic interactions to potentiation of the hippocampal CA1 extracellular population spike during paired pulse or frequency stimulation of stratum radiatum (SR) inputs was investigated using the in vitro hippocampal slice preparation. ...
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Journal ArticleNeuroscience · June 1982
The effect of a transient increase in extracellular calcium concentration on the Schaffer collateral-commissural evoked excitatory postsynaptic potential and population spike responses of CAI pyramidal neurons was investigated using the rat in vitro hippoc ...
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Journal ArticlePostgrad Med J · August 1980
In the U.K., coronary heart disease has reached epidemic proportions. It is the commonest cause of death after the age of 35 years and the fastest rate of increase is in early middle age. The epidemic is due mainly to our way of life. The most important fa ...
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Journal ArticlePostgrad Med J · March 1978
The seeds of premature coronary heart disease are often sown in childhood and it is the developing arteries of children which are the most susceptible. Paediatricians and all who work with them have the earliest and most promising opportunities for prevent ...
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Journal ArticleJ Med Chem · June 1975
Some 2-aryloxymethyl-2,3,5,6-tetrahydro-1,4-oxazines have been shown to possess marked antidepressant activity. The 1,4-oxazines were synthesized by lithium aluminum hydride reduction of the readily available 6-aryloxymethyl-2,3,5,6-tetrahydro-1,4-oxazin-3 ...
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Journal ArticleJournal of Cellular Physiology · February 1967
AbstractBuoyant density distributions of hemopoietic colony‐forming units (CFU) from normal mouse marrow were determined by equilibrium density gradient centrifugation in bovine serum albumin (BSA) gradients. The distributi ...
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Journal ArticleReview of Scientific Instruments · May 1, 1950
An application of x-rays for determination of active slip systems based on a comparison of distortion of Laue spots is described. ...
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Journal ArticleJournal of Applied Physics · August 1, 1949
In order to gain additional information about the origin of preferred orientation of recrystallized grains, the influence of a magnetic field on recrystallization of iron-cobalt alloys is being studied. Preliminary results indicate a change of the ...
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