Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Fellowship, Cardiology, Duke University School of Medicine 2010 - 2013
  • Chief Resident - VAMC, Medicine, Duke University 2009 - 2010
  • Fellow in Cardiology, Medicine, Duke University 2008 - 2009
  • Resident, Medicine, Duke University 2005 - 2008
  • M.D., University of Maryland, College Park 2005
• 

  Duke Appointment History

  • Medical Instructor in the Department of Medicine, Medicine, Cardiology, Medicine 2013 - 2015
  • Medical Instructor in the Department of Medicine, Medicine, General Internal Medicine, Medicine 2009 - 2010
• Research
• 

  Selected Grants

  • PARADISE-MI awarded by Novartis Consumer Health, Inc. 2016 - 2020
  • Augustus awarded by Bristol-Myers Squibb Company 2017 - 2020
  • Compass awarded by Bayer Healthcare Pharmaceuticals Inc 2013 - 2019
  • COMPASS Registry awarded by Hamilton Health Sciences Corporation 2014 - 2015
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Fanaroff, AC, Clare, R, Pieper, KS, Mahaffey, KW, Melloni, C, Green, JB, Alexander, JH, Jones, WS, Harrison, RW, Mehta, RH, Povsic, TJ, Moreira, HG, Al-Khatib, SM, Roe, MT, Kong, DF, Mathews, R, Tricoci, P, Holman, RR, Wallentin, L, Held, C, Califf, RM, Alexander, KP, and Lopes, RD. "Frequency, Regional Variation, and Predictors of Undetermined Cause of Death in Cardiometabolic Clinical Trials: A Pooled Analysis of 9259 Deaths in 9 Trials." Circulation 139, no. 7 (February 2019): 863-873.  Full Text
    • Harrison, RW, Radhakrishnan, V, Allen, JC, Lam, PS, Allocco, DJ, Brar, S, Fahy, M, Zhang, Z, Fisher, R, Ikeno, F, Généreux, P, Kimura, T, Liu, M, Lye, WK, Nagai, H, Suzuki, Y, White, R, and Krucoff, MW. "The East-West late lumen loss study: Comparison of angiographic late lumen loss between Eastern and Western drug-eluting stent study cohorts." American Heart Journal 206 (December 2018): 61-71.  Full Text
    • Hernandez, AF, Green, JB, Janmohamed, S, D'Agostino, RB, Granger, CB, Jones, NP, Leiter, LA, Rosenberg, AE, Sigmon, KN, Somerville, MC, Thorpe, KM, McMurray, JJV, Del Prato, S, and Harmony Outcomes committees and investigators, . "Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial." Lancet (London, England) 392, no. 10157 (October 2, 2018): 1519-1529.  Full Text
    • Anand, SS, Bosch, J, Eikelboom, JW, Connolly, SJ, Diaz, R, Widimsky, P, Aboyans, V, Alings, M, Kakkar, AK, Keltai, K, Maggioni, AP, Lewis, BS, Störk, S, Zhu, J, Lopez-Jaramillo, P, O'Donnell, M, Commerford, PJ, Vinereanu, D, Pogosova, N, Ryden, L, Fox, KAA, Bhatt, DL, Misselwitz, F, Varigos, JD, Vanassche, T, Avezum, AA, Chen, E, Branch, K, Leong, DP, Bangdiwala, SI, Hart, RG, Yusuf, S, and COMPASS Investigators, . "Rivaroxaban with or without aspirin in patients with stable peripheral or carotid artery disease: an international, randomised, double-blind, placebo-controlled trial." Lancet (London, England) 391, no. 10117 (January 2018): 219-229.  Full Text
    • Connolly, SJ, Eikelboom, JW, Bosch, J, Dagenais, G, Dyal, L, Lanas, F, Metsarinne, K, O'Donnell, M, Dans, AL, Ha, J-W, Parkhomenko, AN, Avezum, AA, Lonn, E, Lisheng, L, Torp-Pedersen, C, Widimsky, P, Maggioni, AP, Felix, C, Keltai, K, Hori, M, Yusoff, K, Guzik, TJ, Bhatt, DL, Branch, KRH, Cook Bruns, N, Berkowitz, SD, Anand, SS, Varigos, JD, Fox, KAA, Yusuf, S, and COMPASS investigators, . "Rivaroxaban with or without aspirin in patients with stable coronary artery disease: an international, randomised, double-blind, placebo-controlled trial." Lancet (London, England) 391, no. 10117 (January 2018): 205-218.  Full Text
    • Eikelboom, JW, Connolly, SJ, Bosch, J, Dagenais, GR, Hart, RG, Shestakovska, O, Diaz, R, Alings, M, Lonn, EM, Anand, SS, Widimsky, P, Hori, M, Avezum, A, Piegas, LS, Branch, KRH, Probstfield, J, Bhatt, DL, Zhu, J, Liang, Y, Maggioni, AP, Lopez-Jaramillo, P, O'Donnell, M, Kakkar, AK, Fox, KAA, Parkhomenko, AN, Ertl, G, Störk, S, Keltai, M, Ryden, L, Pogosova, N, Dans, AL, Lanas, F, Commerford, PJ, Torp-Pedersen, C, Guzik, TJ, Verhamme, PB, Vinereanu, D, Kim, J-H, Tonkin, AM, Lewis, BS, Felix, C, Yusoff, K, Steg, PG, Metsarinne, KP, Cook Bruns, N, Misselwitz, F, Chen, E, Leong, D, Yusuf, S, and COMPASS Investigators, . "Rivaroxaban with or without Aspirin in Stable Cardiovascular Disease." The New England Journal of Medicine 377, no. 14 (October 2017): 1319-1330.  Full Text
    • Mehta, RH, Leimberger, JD, van Diepen, S, Meza, J, Wang, A, Jankowich, R, Harrison, RW, Hay, D, Fremes, S, Duncan, A, Soltesz, EG, Luber, J, Park, S, Argenziano, M, Murphy, E, Marcel, R, Kalavrouziotis, D, Nagpal, D, Bozinovski, J, Toller, W, Heringlake, M, Goodman, SG, Levy, JH, Harrington, RA, Anstrom, KJ, Alexander, JH, and LEVO-CTS Investigators, . "Levosimendan in Patients with Left Ventricular Dysfunction Undergoing Cardiac Surgery." The New England Journal of Medicine 376, no. 21 (May 2017): 2032-2042.  Full Text
    • Harrison, RW, Radhakrishnan, V, Lam, PS, Allocco, DJ, Brar, S, Fahy, M, Fisher, R, Ikeno, F, Généreux, P, Kimura, T, Liu, M, Lye, WK, Mintz, GS, Nagai, H, Suzuki, Y, White, R, Allen, JC, and Krucoff, MW. "Rationale and design of the East-West late lumen loss study: Comparison of late lumen loss between Eastern and Western drug-eluting stent study cohorts." American heart journal 182 (December 2016): 103-110.  Full Text
    • Mehta, RH, Van Diepen, S, Meza, J, Bokesch, P, Leimberger, JD, Tourt-Uhlig, S, Swartz, M, Parrotta, J, Jankowich, R, Hay, D, Harrison, RW, Fremes, S, Goodman, SG, Luber, J, Toller, W, Heringlake, M, Anstrom, KJ, Levy, JH, Harrington, RA, Alexander, JH, and LEVO-CTS Investigators, . "Levosimendan in patients with left ventricular systolic dysfunction undergoing cardiac surgery on cardiopulmonary bypass: Rationale and study design of the Levosimendan in Patients with Left Ventricular Systolic Dysfunction Undergoing Cardiac Surgery Requiring Cardiopulmonary Bypass (LEVO-CTS) trial." American Heart Journal 182 (December 2016): 62-71.  Full Text
    • Rymer, JA, Harrison, RW, Dai, D, Roe, MT, Messenger, JC, Anderson, HV, Peterson, ED, and Wang, TY. "Trends in Bare-Metal Stent Use in the United States in Patients Aged ≥65 Years (from the CathPCI Registry)." The American Journal of Cardiology 118, no. 7 (October 2016): 959-966.  Full Text
    • Harrison, RW, Simon, D, Miller, AL, de Lemos, JA, Peterson, ED, and Wang, TY. "Association of hospital myocardial infarction volume with adherence to American College of Cardiology/American Heart Association performance measures: Insights from the National Cardiovascular Data Registry." American Heart Journal 178 (August 2016): 95-101.  Full Text
    • Rodriguez, F, Harrison, RW, Wojdyla, D, and Mahaffey, KW. "Lost to Follow-up and Withdrawal of Consent in Contemporary Global Cardiovascular Randomized Clinical Trials." Critical pathways in cardiology 14, no. 4 (December 2015): 150-153. (Review)  Full Text
    • Rao, SV, Zeymer, U, Douglas, PS, Al-Khalidi, H, Liu, J, Gibson, CM, Harrison, RW, Joseph, DS, Heyrman, R, and Krucoff, MW. "A randomized, double-blind, placebo-controlled trial to evaluate the safety and effectiveness of intracoronary application of a novel bioabsorbable cardiac matrix for the prevention of ventricular remodeling after large ST-segment elevation myocardial infarction: Rationale and design of the PRESERVATION I trial." American heart journal 170, no. 5 (November 2015): 929-937.  Full Text
    • Jiang, W, Boyle, SH, Ortel, TL, Samad, Z, Velazquez, EJ, Harrison, RW, Wilson, J, Kuhn, C, Williams, RB, O'Connor, CM, and Becker, RC. "Platelet aggregation and mental stress induced myocardial ischemia: Results from the Responses of Myocardial Ischemia to Escitalopram Treatment (REMIT) study." American heart journal 169, no. 4 (April 2015): 496-507.e1.  Full Text  Open Access Copy
    • Jiang, W, Boyle, SH, Ortel, TL, Samad, Z, Velazquez, EJ, Harrison, RW, Wilson, J, Kuhn, C, Williams, RB, O'Connor, CM, and Becker, RC. "Platelet aggregation and mental stress induced myocardial ischemia: Results from the Responses of Myocardial Ischemia to Escitalopram Treatment (REMIT) study." American Heart Journal 169, no. 4 (January 1, 2015): 496-507.e1.  Full Text
    • Harrison, RW, Hasselblad, V, Mehta, RH, Levin, R, Harrington, RA, and Alexander, JH. "Effect of levosimendan on survival and adverse events after cardiac surgery: A meta-analysis." Journal of Cardiothoracic and Vascular Anesthesia 27, no. 6 (December 1, 2013): 1224-1232.  Full Text
    • Harrison, RW, Hasselblad, V, Mehta, RH, Levin, R, Harrington, RA, and Alexander, JH. "Effect of levosimendan on survival and adverse events after cardiac surgery: a meta-analysis." Journal of Cardiothoracic and Vascular Anesthesia 27, no. 6 (December 2013): 1224-1232. (Review)  Full Text
    • Harrison, RW, Aggarwal, A, Ou, F-S, Klein, LW, Rumsfeld, JS, Roe, MT, Wang, TY, and American College of Cardiology National Cardiovascular Data Registry, . "Incidence and outcomes of no-reflow phenomenon during percutaneous coronary intervention among patients with acute myocardial infarction." The American Journal of Cardiology 111, no. 2 (January 2013): 178-184.  Full Text
    • Harrison, RW, Aggarwal, A, Ou, F-S, Klein, LW, Rumsfeld, JS, Roe, MT, and Wang, TY. "Incidence and outcomes of no-reflow phenomenon during percutaneous coronary intervention among patients with acute myocardial infarction." American Journal of Cardiology 111, no. 2 (2013): 178-184.  Full Text
    • Harrison, R, Miller, A, Holmes, D, de Lemos, J, Peterson, ED, and Wang, TY. "Association of Hospital Myocardial Infarction Volume with Adherence to ACC/AHA Performance Measures: Insights from the NCDR (R)." Circulation 126, no. 21 (November 20, 2012).  Link to Item
    • Harrison, RW, Ortel, TL, and Becker, RC. "To bridge or not to bridge: these are the questions." J Thromb Thrombolysis 34, no. 1 (July 2012): 31-35. (Review)  Full Text  Link to Item
    • Beigi, F, Gonzalez, DR, Minhas, KM, Sun, Q-A, Foster, MW, Khan, SA, Treuer, AV, Dulce, RA, Harrison, RW, Saraiva, RM, Premer, C, Schulman, IH, Stamler, JS, and Hare, JM. "Dynamic denitrosylation via S-nitrosoglutathione reductase regulates cardiovascular function." Proceedings of the National Academy of Sciences of the United States of America 109, no. 11 (March 2012): 4314-4319.  Full Text
    • Harrison, RW, and Mahaffey, KW. "Clopidogrel and PPI interaction: clinically relevant or not?." Current Cardiology Reports 14, no. 1 (February 2012): 49-58. (Review)  Full Text
    • Jung, AS, Harrison, R, Lee, KH, Genut, J, Nyhan, D, Brooks-Asplund, EM, Shoukas, AA, Hare, JM, and Berkowitz, DE. "Simulated microgravity produces attenuated baroreflex-mediated pressor, chronotropic, and inotropic responses in mice." American Journal of Physiology. Heart and Circulatory Physiology 289, no. 2 (August 2005): H600-H607.  Full Text
    • Townsend, SA, Jung, AS, Hoe, YSG, Lefkowitz, RY, Khan, SA, Lemmon, CA, Harrison, RW, Lee, K, Barouch, LA, Cotecchia, S, Shoukas, AA, Nyhan, D, Hare, JM, and Berkowitz, DE. "Critical role for the α-1B adrenergic receptor at the sympathetic neuroeffector junction." Hypertension 44, no. 5 (2004): 776-782.  Full Text
    • Barouch, LA, Berkowitz, DE, Harrison, RW, O'Donnell, CP, and Hare, JM. "Disruption of leptin signaling contributes to cardiac hypertrophy independently of body weight in mice." Circulation 108, no. 6 (August 2003): 754-759.  Full Text
    • Khan, SA, Skaf, MW, Harrison, RW, Lee, K, Minhas, KM, Kumar, A, Fradley, M, Shoukas, AA, Berkowitz, DE, and Hare, JM. "Nitric oxide regulation of myocardial contractility and calcium cycling: independent impact of neuronal and endothelial nitric oxide synthases." Circulation Research 92, no. 12 (June 2003): 1322-1329.  Full Text
    • Barouch, LA, Cappola, TP, Harrison, RW, Crone, JK, Rodriguez, ER, Burnett, AL, and Hare, JM. "Combined loss of neuronal and endothelial nitric oxide synthase causes premature mortality and age-related hypertrophic cardiac remodeling in mice." Journal of Molecular and Cellular Cardiology 35, no. 6 (2003): 637-644.  Full Text
    • Barouch, LA, Harrison, RW, Skaf, MW, Rosas, GO, Cappola, TP, Kobeissi, ZA, Hobai, IA, Lemmon, CA, Burnett, AL, O'Rourke, B, Rodriguez, ER, Huang, PL, Lima, JAC, Berkowitz, DE, and Hare, JM. "Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms." Nature 416, no. 6878 (March 2002): 337-339.  Full Text
    • Saavedra, WF, Paolocci, N, St John, ME, Skaf, MW, Stewart, GC, Xie, J-S, Harrison, RW, Zeichner, J, Mudrick, D, Marbán, E, Kass, DA, and Hare, JM. "Imbalance between xanthine oxidase and nitric oxide synthase signaling pathways underlies mechanoenergetic uncoupling in the failing heart." Circulation Research 90, no. 3 (February 2002): 297-304.  Full Text
    • Harrison, RW, Thakkar, RN, Senzaki, H, Ekelund, UEG, Cho, E, Kass, DA, and Hare, JM. "Relative contribution of preload and afterload to the reduction in cardiac output caused by nitric oxide synthase inhibition with L-N(G)- methylarginine hydrochloride 546C88." Critical Care Medicine 28, no. 5 (2000): 1263-1268.
    • Paolocc, N, Ekelund, UEG, Isoda, T, Ozaki, M, Vandegaer, K, Georgakopoulos, D, Harrison, RW, Kass, DA, and Hare, JM. "cGMP-independent inotropic effects of nitric oxide and peroxynitrite donors: Potential role for nitrosylation." American Journal of Physiology - Heart and Circulatory Physiology 279, no. 4 48-4 (2000): H1982-H1988.
    • Varghese, P, Harrison, RW, Lofthouse, RA, Georgakopoulos, D, Berkowitz, DE, and Hare, JM. "β₃-adrenoceptor deficiency blocks nitric oxide-dependent inhibition of myocardial contractility." Journal of Clinical Investigation 106, no. 5 (2000): 697-703.  Full Text
    • Ekelund, UEG, Harrison, RW, Shokek, O, Thakkar, RN, Tunin, RS, Senzaki, H, Kass, DA, Marbán, E, and Hare, JM. "Intravenous allopurinol decreases myocardial oxygen consumption and increases mechanical efficiency in dogs with pacing-induced heart failure." Circulation Research 85, no. 5 (1999): 437-445.

  • Other Articles

    • Kirby, R, Brawer, M, and Moul, J. "Editorial." Prostate Cancer and Prostatic Diseases 6, no. 1 (January 1, 2003): 1-null.  Full Text

  • Conference Papers

    • Fanaroff, AC, Clare, R, Pieper, K, Mahaffey, K, Melloni, C, Green, J, Alexander, J, Jones, W, Harrison, R, Mehta, R, Povsic, T, Moreira, H, Al-Khatib, S, Roe, M, Kong, D, Mathews, R, Tricoci, P, Holman, R, Wallentin, L, Held, C, Alexander, K, and Lopes, R. "UNDETERMINED CAUSE OF DEATH: A POOLED ANALYSIS OF 9,307 DEATHS ACROSS 9 CARDIOVASCULAR TRIALS." : Elsevier BV, March 2018.  Full Text
    • Douketis, J, Spyropoulos, A, Kaatz, S, Caprini, J, Dunn, A, Garcia, D, Jacobson, A, Jaffer, A, Kindzelski, A, Schulman, S, Turpie, AG, Becker, R, Clark, NP, Conti, B, Ellsworth, S, Harrison, RW, Kong, D, Johnson, G, Krishnamoorthy, A, Palmeri, S, Parker, W, Saucedo, J, Schoch, P, Tallman, D, Witt, D, Hasselblad, V, Ortel, TL, and Investigators, BRIDGES. "Bridging anticoagulation in patients who require temporary interruption of warfarin therapy for an elective invasive procedure or surgery (the bridge trial)." June 2015.  Link to Item
    • Radhakrishnan, V, Allen, JC, Fisher, R, Lye, WK, Harrison, RW, and Krucoff, MW. "Generalizability of Quantitative Angiographic In-Segment Late Lumen Loss Imaging in Eastern and Western Populations: Can We Facilitate Global Drug Eluting Stent Evaluation?." : LIPPINCOTT WILLIAMS & WILKINS, November 25, 2014.  Link to Item
    • Harrison, RW, Becker, R, Ortel, T, Kuchibhatla, M, Boyle, S, Samad, Z, Velazquez, E, Wilson, J, Kuhn, C, and Williams, R. "ASSOCIATION BETWEEN PLATELET AGGREGATION AND MENTAL STRESS INDUCED MYOCARDIAL ISCHEMIA: RESULTS FROM THE REMIT TRIAL." : Elsevier BV, March 2013.  Full Text
    • Harrison, R, Hasselblad, V, Levin, R, Mehta, R, Harrington, R, and Alexander, J. "LEVOSIMENDAN REDUCES MORTALITY IN PATIENTS WITH REDUCED EJECTION FRACTION UNDERGOING CARDIAC SURGERY: A META-ANALYSIS OF RANDOMIZED CLINICAL TRIALS." : Elsevier BV, March 2012.  Full Text
    • Beigi, F, Gonzalez, DR, Khan, S, Foster, M, Forrester, MT, Minhas, KM, Zheng, M, Harrison, R, Stamler, JS, and Hare, JM. "S-nitrosylation-based signaling regulates myocardial contractility." 80th Annual Scientific Session of the American-Heart-Association. Orlando, FL. November 4, 2007 - November 7, 2007.: LIPPINCOTT WILLIAMS & WILKINS, October 16, 2007.  Link to Item

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