Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Fellowship, Cardiology, Duke University School of Medicine 2010 - 2013
  • Chief Resident - VAMC, Medicine, Duke University 2009 - 2010
  • Fellow in Cardiology, Medicine, Duke University 2008 - 2009
  • Resident, Medicine, Duke University 2005 - 2008
  • M.D., University of Maryland, College Park 2005
• 

  Duke Appointment History

  • Medical Instructor in the Department of Medicine, Medicine, Cardiology, Medicine 2013 - 2015
  • Medical Instructor in the Department of Medicine, Medicine, General Internal Medicine, Medicine 2009 - 2010
• Research
• 

  Selected Grants

  • A randomized controlled trial of rivaroxaban for the prevent of major cardiovascular events in patients with coronaryor periphery artery disease (COMPASS - Cardiovascular OutcoMes for People using Anticoagulation) 2013 - 2020
  • Prospective ARNI verses ACE inhibitor trial to determine superiority in reducing heart failure events after MI 2016 - 2020
  • Augustus 2017 - 2020
  • A registry of high risk patients with coronary or peripheral artery disease 2014 - 2015
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • DeVore, Adam D., Bradi B. Granger, Gregg C. Fonarow, Hussein R. Al-Khalidi, Nancy M. Albert, Eldrin F. Lewis, Javed Butler, et al. “Care Optimization Through Patient and Hospital Engagement Clinical Trial for Heart Failure: Rationale and design of CONNECT-HF.” Am Heart J 220 (February 2020): 41–50. https://doi.org/10.1016/j.ahj.2019.09.012.
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    • Roe, Matthew T., Qian H. Li, Deepak L. Bhatt, Vera A. Bittner, Rafael Diaz, Shaun G. Goodman, Robert A. Harrington, et al. “Risk Categorization Using New American College of Cardiology/American Heart Association Guidelines for Cholesterol Management and Its Relation to Alirocumab Treatment Following Acute Coronary Syndromes.” Circulation 140, no. 19 (November 5, 2019): 1578–89. https://doi.org/10.1161/CIRCULATIONAHA.119.042551.
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    • Szarek, Michael, Ph Gabriel Steg, Dina DiCenso, Deepak L. Bhatt, Vera A. Bittner, Andrzej Budaj, Rafael Diaz, et al. “Alirocumab Reduces Total Hospitalizations and Increases Days Alive and Out of Hospital in the ODYSSEY OUTCOMES Trial.” Circ Cardiovasc Qual Outcomes 12, no. 11 (November 2019): e005858. https://doi.org/10.1161/CIRCOUTCOMES.119.005858.
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    • Jukema, J Wouter, Michael Szarek, Laurien E. Zijlstra, H Asita de Silva, Deepak L. Bhatt, Vera A. Bittner, Rafael Diaz, et al. “Alirocumab in Patients With Polyvascular Disease and Recent Acute Coronary Syndrome: ODYSSEY OUTCOMES Trial.” J Am Coll Cardiol 74, no. 9 (September 3, 2019): 1167–76. https://doi.org/10.1016/j.jacc.2019.03.013.
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    • Ray, Kausik K., Helen M. Colhoun, Michael Szarek, Marie Baccara-Dinet, Deepak L. Bhatt, Vera A. Bittner, Andrzej J. Budaj, et al. “Effects of alirocumab on cardiovascular and metabolic outcomes after acute coronary syndrome in patients with or without diabetes: a prespecified analysis of the ODYSSEY OUTCOMES randomised controlled trial.” Lancet Diabetes Endocrinol 7, no. 8 (August 2019): 618–28. https://doi.org/10.1016/S2213-8587(19)30158-5.
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    • Steg, Philippe Gabriel, Michael Szarek, Deepak L. Bhatt, Vera A. Bittner, Marie-France Brégeault, Anthony J. Dalby, Rafael Diaz, et al. “Effect of Alirocumab on Mortality After Acute Coronary Syndromes.” Circulation 140, no. 2 (July 9, 2019): 103–12. https://doi.org/10.1161/CIRCULATIONAHA.118.038840.
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    • Lopes, Renato D., Gretchen Heizer, Ronald Aronson, Amit N. Vora, Tyler Massaro, Roxana Mehran, Shaun G. Goodman, et al. “Antithrombotic Therapy after Acute Coronary Syndrome or PCI in Atrial Fibrillation.” N Engl J Med 380, no. 16 (April 18, 2019): 1509–24. https://doi.org/10.1056/NEJMoa1817083.
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    • Fanaroff, Alexander C., Robert Clare, Karen S. Pieper, Kenneth W. Mahaffey, Chiara Melloni, Jennifer B. Green, John H. Alexander, et al. “Frequency, Regional Variation, and Predictors of Undetermined Cause of Death in Cardiometabolic Clinical Trials: A Pooled Analysis of 9259 Deaths in 9 Trials.” Circulation 139, no. 7 (February 12, 2019): 863–73. https://doi.org/10.1161/CIRCULATIONAHA.118.037202.
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    • Szarek, Michael, Harvey D. White, Gregory G. Schwartz, Marco Alings, Deepak L. Bhatt, Vera A. Bittner, Chern-En Chiang, et al. “Alirocumab Reduces Total Nonfatal Cardiovascular and Fatal Events: The ODYSSEY OUTCOMES Trial.” J Am Coll Cardiol 73, no. 4 (February 5, 2019): 387–96. https://doi.org/10.1016/j.jacc.2018.10.039.
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    • Harrison, Robert W., Vaishnavi Radhakrishnan, John C. Allen, Peter S. Lam, Dominic J. Allocco, Sandeep Brar, Martin Fahy, et al. “The East-West late lumen loss study: Comparison of angiographic late lumen loss between Eastern and Western drug-eluting stent study cohorts.” Am Heart J 206 (December 2018): 61–71. https://doi.org/10.1016/j.ahj.2018.08.017.
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    • Hernandez, Adrian F., Jennifer B. Green, Salim Janmohamed, Ralph B. D’Agostino, Christopher B. Granger, Nigel P. Jones, Lawrence A. Leiter, et al. “Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial.” Lancet 392, no. 10157 (October 27, 2018): 1519–29. https://doi.org/10.1016/S0140-6736(18)32261-X.
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    • Anand, Sonia S., Jackie Bosch, John W. Eikelboom, Stuart J. Connolly, Rafael Diaz, Peter Widimsky, Victor Aboyans, et al. “Rivaroxaban with or without aspirin in patients with stable peripheral or carotid artery disease: an international, randomised, double-blind, placebo-controlled trial.” Lancet 391, no. 10117 (January 20, 2018): 219–29. https://doi.org/10.1016/S0140-6736(17)32409-1.
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    • Connolly, Stuart J., John W. Eikelboom, Jackie Bosch, Gilles Dagenais, Leanne Dyal, Fernando Lanas, Kaj Metsarinne, et al. “Rivaroxaban with or without aspirin in patients with stable coronary artery disease: an international, randomised, double-blind, placebo-controlled trial.” Lancet 391, no. 10117 (January 20, 2018): 205–18. https://doi.org/10.1016/S0140-6736(17)32458-3.
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    • Eikelboom, John W., Stuart J. Connolly, Jackie Bosch, Gilles R. Dagenais, Robert G. Hart, Olga Shestakovska, Rafael Diaz, et al. “Rivaroxaban with or without Aspirin in Stable Cardiovascular Disease.” N Engl J Med 377, no. 14 (October 5, 2017): 1319–30. https://doi.org/10.1056/NEJMoa1709118.
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    • Mehta, Rajendra H., Jeffrey D. Leimberger, Sean van Diepen, James Meza, Alice Wang, Rachael Jankowich, Robert W. Harrison, et al. “Levosimendan in Patients with Left Ventricular Dysfunction Undergoing Cardiac Surgery.” N Engl J Med 376, no. 21 (May 25, 2017): 2032–42. https://doi.org/10.1056/NEJMoa1616218.
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    • Harrison, Robert W., Vaishnavi Radhakrishnan, Peter S. Lam, Dominic J. Allocco, Sandeep Brar, Martin Fahy, Rebecca Fisher, et al. “Rationale and design of the East-West late lumen loss study: Comparison of late lumen loss between Eastern and Western drug-eluting stent study cohorts.” Am Heart J 182 (December 2016): 103–10. https://doi.org/10.1016/j.ahj.2016.07.011.
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    • Mehta, Rajendra H., Sean Van Diepen, James Meza, Paula Bokesch, Jeffrey D. Leimberger, Sandra Tourt-Uhlig, Merri Swartz, et al. “Levosimendan in patients with left ventricular systolic dysfunction undergoing cardiac surgery on cardiopulmonary bypass: Rationale and study design of the Levosimendan in Patients with Left Ventricular Systolic Dysfunction Undergoing Cardiac Surgery Requiring Cardiopulmonary Bypass (LEVO-CTS) trial.” Am Heart J 182 (December 2016): 62–71. https://doi.org/10.1016/j.ahj.2016.09.001.
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    • Rymer, Jennifer A., Robert W. Harrison, David Dai, Matthew T. Roe, John C. Messenger, H Vernon Anderson, Eric D. Peterson, and Tracy Y. Wang. “Trends in Bare-Metal Stent Use in the United States in Patients Aged ≥65 Years (from the CathPCI Registry).” Am J Cardiol 118, no. 7 (October 1, 2016): 959–66. https://doi.org/10.1016/j.amjcard.2016.06.061.
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    • Harrison, Robert W., DaJuanicia Simon, Amy L. Miller, James A. de Lemos, Eric D. Peterson, and Tracy Y. Wang. “Association of hospital myocardial infarction volume with adherence to American College of Cardiology/American Heart Association performance measures: Insights from the National Cardiovascular Data Registry.” Am Heart J 178 (August 2016): 95–101. https://doi.org/10.1016/j.ahj.2016.04.002.
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    • Rodriguez, Fatima, Robert W. Harrison, Daniel Wojdyla, and Kenneth W. Mahaffey. “Lost to Follow-up and Withdrawal of Consent in Contemporary Global Cardiovascular Randomized Clinical Trials.” Crit Pathw Cardiol 14, no. 4 (December 2015): 150–53. https://doi.org/10.1097/HPC.0000000000000055.
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    • Rao, Sunil V., Uwe Zeymer, Pamela S. Douglas, Hussein Al-Khalidi, Jingyu Liu, C Michael Gibson, Robert W. Harrison, Diane S. Joseph, Reinilde Heyrman, and Mitchell W. Krucoff. “A randomized, double-blind, placebo-controlled trial to evaluate the safety and effectiveness of intracoronary application of a novel bioabsorbable cardiac matrix for the prevention of ventricular remodeling after large ST-segment elevation myocardial infarction: Rationale and design of the PRESERVATION I trial.” Am Heart J 170, no. 5 (November 2015): 929–37. https://doi.org/10.1016/j.ahj.2015.08.017.
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    • Jiang, Wei, Stephen H. Boyle, Thomas L. Ortel, Zainab Samad, Eric J. Velazquez, Robert W. Harrison, Jennifer Wilson, et al. “Platelet aggregation and mental stress induced myocardial ischemia: Results from the Responses of Myocardial Ischemia to Escitalopram Treatment (REMIT) study.” Am Heart J 169, no. 4 (April 2015): 496-507.e1. https://doi.org/10.1016/j.ahj.2014.12.002.
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    • Jiang, W., S. H. Boyle, T. L. Ortel, Z. Samad, E. J. Velazquez, R. W. Harrison, J. Wilson, et al. “Platelet aggregation and mental stress induced myocardial ischemia: Results from the Responses of Myocardial Ischemia to Escitalopram Treatment (REMIT) study.” American Heart Journal 169, no. 4 (January 1, 2015): 496-507.e1. https://doi.org/10.1016/j.ahj.2014.12.002.
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    • Harrison, Robert W., Vic Hasselblad, Rajendra H. Mehta, Ricardo Levin, Robert A. Harrington, and John H. Alexander. “Effect of levosimendan on survival and adverse events after cardiac surgery: a meta-analysis.” J Cardiothorac Vasc Anesth 27, no. 6 (December 2013): 1224–32. https://doi.org/10.1053/j.jvca.2013.03.027.
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    • Harrison, Robert W., Atul Aggarwal, Fang-shu Ou, Lloyd W. Klein, John S. Rumsfeld, Matthew T. Roe, Tracy Y. Wang, and Tracy Y. American College of Cardiology National Cardiovascular Data Registry. “Incidence and outcomes of no-reflow phenomenon during percutaneous coronary intervention among patients with acute myocardial infarction.” Am J Cardiol 111, no. 2 (January 15, 2013): 178–84. https://doi.org/10.1016/j.amjcard.2012.09.015.
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    • Harrison, Robert, Amy Miller, DaJuanicia Holmes, James de Lemos, Eric D. Peterson, and Tracy Y. Wang. “Association of Hospital Myocardial Infarction Volume with Adherence to ACC/AHA Performance Measures: Insights from the NCDR (R).” Circulation 126, no. 21 (November 20, 2012).
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    • Harrison, Robert W., Thomas L. Ortel, and Richard C. Becker. “To bridge or not to bridge: these are the questions.” J Thromb Thrombolysis 34, no. 1 (July 2012): 31–35. https://doi.org/10.1007/s11239-012-0732-8.
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    • Beigi, Farideh, Daniel R. Gonzalez, Khalid M. Minhas, Qi-An Sun, Matthew W. Foster, Shakil A. Khan, Adriana V. Treuer, et al. “Dynamic denitrosylation via S-nitrosoglutathione reductase regulates cardiovascular function.” Proc Natl Acad Sci U S A 109, no. 11 (March 13, 2012): 4314–19. https://doi.org/10.1073/pnas.1113319109.
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    • Harrison, Robert W., and Kenneth W. Mahaffey. “Clopidogrel and PPI interaction: clinically relevant or not?” Curr Cardiol Rep 14, no. 1 (February 2012): 49–58. https://doi.org/10.1007/s11886-011-0233-y.
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    • Jung, Albert S., Robert Harrison, Kwang H. Lee, Jordan Genut, Daniel Nyhan, E. M. Brooks-Asplund, Artin A. Shoukas, Joshua M. Hare, and Dan E. Berkowitz. “Simulated microgravity produces attenuated baroreflex-mediated pressor, chronotropic, and inotropic responses in mice.” Am J Physiol Heart Circ Physiol 289, no. 2 (August 2005): H600–607. https://doi.org/10.1152/ajpheart.01091.2004.
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    • Townsend, Seth A., Albert S. Jung, Yen Shi Gillian Hoe, Rafael Y. Lefkowitz, Shakil A. Khan, Christoper A. Lemmon, Robert W. Harrison, et al. “Critical role for the alpha-1B adrenergic receptor at the sympathetic neuroeffector junction.” Hypertension 44, no. 5 (November 2004): 776–82. https://doi.org/10.1161/01.HYP.0000145405.01113.0e.
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    • Barouch, Lili A., Dan E. Berkowitz, Robert W. Harrison, Christopher P. O’Donnell, and Joshua M. Hare. “Disruption of leptin signaling contributes to cardiac hypertrophy independently of body weight in mice.” Circulation 108, no. 6 (August 12, 2003): 754–59. https://doi.org/10.1161/01.CIR.0000083716.82622.FD.
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    • Khan, Shakil A., Michel W. Skaf, Robert W. Harrison, Kwangho Lee, Khalid M. Minhas, Anil Kumar, Mike Fradley, Artin A. Shoukas, Dan E. Berkowitz, and Joshua M. Hare. “Nitric oxide regulation of myocardial contractility and calcium cycling: independent impact of neuronal and endothelial nitric oxide synthases.” Circ Res 92, no. 12 (June 27, 2003): 1322–29. https://doi.org/10.1161/01.RES.0000078171.52542.9E.
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    • Barouch, Lili A., Thomas P. Cappola, Robert W. Harrison, Julie K. Crone, E Rene Rodriguez, Arthur L. Burnett, and Joshua M. Hare. “Combined loss of neuronal and endothelial nitric oxide synthase causes premature mortality and age-related hypertrophic cardiac remodeling in mice.” J Mol Cell Cardiol 35, no. 6 (June 2003): 637–44. https://doi.org/10.1016/s0022-2828(03)00079-8.
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    • Barouch, Lili A., Robert W. Harrison, Michel W. Skaf, Gisele O. Rosas, Thomas P. Cappola, Zoulficar A. Kobeissi, Ion A. Hobai, et al. “Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms.” Nature 416, no. 6878 (March 21, 2002): 337–39. https://doi.org/10.1038/416337a.
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    • Saavedra, Walter F., Nazareno Paolocci, Marcus E. St John, Michel W. Skaf, Garrick C. Stewart, Jin-Sheng Xie, Robert W. Harrison, et al. “Imbalance between xanthine oxidase and nitric oxide synthase signaling pathways underlies mechanoenergetic uncoupling in the failing heart.” Circ Res 90, no. 3 (February 22, 2002): 297–304. https://doi.org/10.1161/hh0302.104531.
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    • Paolocci, N., U. E. Ekelund, T. Isoda, M. Ozaki, K. Vandegaer, D. Georgakopoulos, R. W. Harrison, D. A. Kass, and J. M. Hare. “cGMP-independent inotropic effects of nitric oxide and peroxynitrite donors: potential role for nitrosylation.” Am J Physiol Heart Circ Physiol 279, no. 4 (October 2000): H1982–88. https://doi.org/10.1152/ajpheart.2000.279.4.H1982.
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    • Varghese, P., R. W. Harrison, R. A. Lofthouse, D. Georgakopoulos, D. E. Berkowitz, and J. M. Hare. “beta(3)-adrenoceptor deficiency blocks nitric oxide-dependent inhibition of myocardial contractility.” J Clin Invest 106, no. 5 (September 2000): 697–703. https://doi.org/10.1172/JCI9323.
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    • Harrison, R. W., R. N. Thakkar, H. Senzaki, U. E. Ekelund, E. Cho, D. A. Kass, and J. M. Hare. “Relative contribution of preload and afterload to the reduction in cardiac output caused by nitric oxide synthase inhibition with L-N(G)-methylarginine hydrochloride 546C88.” Crit Care Med 28, no. 5 (May 2000): 1263–68. https://doi.org/10.1097/00003246-200005000-00001.
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    • Ekelund, U. E., R. W. Harrison, O. Shokek, R. N. Thakkar, R. S. Tunin, H. Senzaki, D. A. Kass, E. Marbán, and J. M. Hare. “Intravenous allopurinol decreases myocardial oxygen consumption and increases mechanical efficiency in dogs with pacing-induced heart failure.” Circ Res 85, no. 5 (September 3, 1999): 437–45. https://doi.org/10.1161/01.res.85.5.437.
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  • Conference Papers

    • Fanaroff, Alexander C., Robert Clare, Karen Pieper, Kenneth Mahaffey, Chiara Melloni, Jennifer Green, John Alexander, et al. “UNDETERMINED CAUSE OF DEATH: A POOLED ANALYSIS OF 9,307 DEATHS ACROSS 9 CARDIOVASCULAR TRIALS.” In Journal of the American College of Cardiology, 71:A90–A90. Elsevier BV, 2018. https://doi.org/10.1016/s0735-1097(18)30631-4.
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    • Douketis, J., A. Spyropoulos, S. Kaatz, J. Caprini, A. Dunn, D. Garcia, A. Jacobson, et al. “Bridging anticoagulation in patients who require temporary interruption of warfarin therapy for an elective invasive procedure or surgery (the bridge trial).” In Journal of Thrombosis and Haemostasis, 13:83–84. WILEY-BLACKWELL, 2015.
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    • Radhakrishnan, Vaishnavi, John C. Allen, Rebecca Fisher, Weng Kit Lye, Robert W. Harrison, and Mitchell W. Krucoff. “Generalizability of Quantitative Angiographic In-Segment Late Lumen Loss Imaging in Eastern and Western Populations: Can We Facilitate Global Drug Eluting Stent Evaluation?” In Circulation, Vol. 130. LIPPINCOTT WILLIAMS & WILKINS, 2014.
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    • Harrison, Robert W., Richard Becker, Thomas Ortel, Maggie Kuchibhatla, Stephen Boyle, Zainab Samad, Eric Velazquez, Jennifer Wilson, Cynthia Kuhn, and Redford Williams. “ASSOCIATION BETWEEN PLATELET AGGREGATION AND MENTAL STRESS INDUCED MYOCARDIAL ISCHEMIA: RESULTS FROM THE REMIT TRIAL.” In Journal of the American College of Cardiology, 61:E1135–E1135. Elsevier BV, 2013. https://doi.org/10.1016/s0735-1097(13)61135-3.
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    • Harrison, Robert, Victor Hasselblad, Ricardo Levin, Rajendra Mehta, Robert Harrington, and John Alexander. “LEVOSIMENDAN REDUCES MORTALITY IN PATIENTS WITH REDUCED EJECTION FRACTION UNDERGOING CARDIAC SURGERY: A META-ANALYSIS OF RANDOMIZED CLINICAL TRIALS.” In Journal of the American College of Cardiology, 59:E959–E959. Elsevier BV, 2012. https://doi.org/10.1016/s0735-1097(12)60960-7.
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    • Beigi, Farideh, Daniel R. Gonzalez, Shalkil Khan, Matt Foster, Michael T. Forrester, Khalid M. Minhas, Meizi Zheng, Robert Harrison, Jonathan S. Stamler, and Joshua M. Hare. “S-nitrosylation-based signaling regulates myocardial contractility.” In Circulation, 116:30–30. LIPPINCOTT WILLIAMS & WILKINS, 2007.
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