Scholars@Duke
Robin Mathews

Robin Mathews

Assistant Professor of Medicine
Medicine, Cardiology
robin.mathews@duke.edu
1821 Hillandale Road, Suite 25C, Durham, NC 27705

Selected Publications

Cardiac Myosin Activation with Omecamtiv Mecarbil in Systolic Heart Failure.

Journal Article N Engl J Med · January 14, 2021 BACKGROUND: The selective cardiac myosin activator omecamtiv mecarbil has been shown to improve cardiac function in patients with heart failure with a reduced ejection fraction. Its effect on cardiovascular outcomes is unknown. METHODS: We randomly assigne ... Full text Link to item Cite

Hospital participation in clinical trials for patients with acute myocardial infarction: Results from the National Cardiovascular Data Registry.

Journal Article Am Heart J · August 2019 BACKGROUND: Little is known about the proportion of hospitals in the United States that offer clinical trial enrollment opportunities and how patient outcomes differ between hospitals that do and do not participate in clinical trials. METHODS: In the natio ... Full text Link to item Cite

Frequency, Regional Variation, and Predictors of Undetermined Cause of Death in Cardiometabolic Clinical Trials: A Pooled Analysis of 9259 Deaths in 9 Trials.

Journal Article Circulation · February 12, 2019 BACKGROUND: Modern cardiometabolic clinical trials often include cardiovascular death as a component of a composite primary outcome, requiring central adjudication by a clinical events committee to classify cause of death. However, sometimes the cause of d ... Full text Link to item Cite

Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial.

Journal Article Lancet · October 27, 2018 BACKGROUND: Glucagon-like peptide 1 receptor agonists differ in chemical structure, duration of action, and in their effects on clinical outcomes. The cardiovascular effects of once-weekly albiglutide in type 2 diabetes are unknown. We aimed to determine t ... Full text Link to item Cite

Hospital Variation in Adherence Rates to Secondary Prevention Medications and the Implications on Quality.

Journal Article Circulation · May 15, 2018 BACKGROUND: Medication adherence is important to improve the long-term outcomes after acute myocardial infarction (MI). We hypothesized that there is significant variation among US hospitals in terms of medication adherence after MI, and that patients trea ... Full text Link to item Cite

A Randomized Trial of Pocket-Echocardiography Integrated Mobile Health Device Assessments in Modern Structural Heart Disease Clinics.

Journal Article JACC Cardiovasc Imaging · April 2018 OBJECTIVES: This study sought to determine whether mobile health (mHealth) device assessments used as clinical decision support tools at the point-of-care can reduce the time to treatment and improve long-term outcomes among patients with rheumatic and str ... Full text Link to item Cite

UNDETERMINED CAUSE OF DEATH: A POOLED ANALYSIS OF 9,307 DEATHS ACROSS 9 CARDIOVASCULAR TRIALS

Conference Journal of the American College of Cardiology · March 2018 Full text Cite

Comparison of performance on Hospital Compare process measures and patient outcomes between hospitals that do and do not participate in Acute Coronary Treatment and Intervention Outcomes Network Registry-Get With The Guidelines.

Journal Article Am Heart J · May 2016 BACKGROUND: Acute Coronary Treatment and Intervention Outcomes Network Registry-Get With The Guidelines (ACTION Registry-GWTG) was designed to measure and improve the treatment and outcomes of patients with acute myocardial infarction (AMI), yet it is unkn ... Full text Link to item Cite

Early Medication Nonadherence After Acute Myocardial Infarction: Insights into Actionable Opportunities From the TReatment with ADP receptor iNhibitorS: Longitudinal Assessment of Treatment Patterns and Events after Acute Coronary Syndrome (TRANSLATE-ACS) Study.

Journal Article Circ Cardiovasc Qual Outcomes · July 2015 BACKGROUND: Nonadherence to prescribed evidence-based medications after acute myocardial infarction (MI) can contribute to worse outcomes and higher costs. We sought to better understand the modifiable factors contributing to early nonadherence of evidence ... Full text Link to item Cite

Persistence with secondary prevention medications after acute myocardial infarction: Insights from the TRANSLATE-ACS study.

Journal Article Am Heart J · July 2015 BACKGROUND: Persistent use of secondary prevention therapies after acute myocardial infarction (MI) is critical to optimizing long-term outcomes. METHODS: Medication persistence was assessed among 7,955 MI patients in 216 hospitals participating in the Tre ... Full text Link to item Cite

Patient-centered priorities for improving medication management and adherence.

Journal Article Patient Educ Couns · January 2015 OBJECTIVE: The Centers for Education and Research on Therapeutics convened a workshop to examine the scientific evidence on medication adherence interventions from the patient-centered perspective and to explore the potential of patient-centered medication ... Full text Open Access Link to item Cite

Patient-centered interventions to improve medication management and adherence: a qualitative review of research findings.

Journal Article Patient Educ Couns · December 2014 OBJECTIVE: Patient-centered approaches to improving medication adherence hold promise, but evidence of their effectiveness is unclear. This review reports the current state of scientific research around interventions to improve medication management throug ... Full text Link to item Cite

Check it, change it: a community-based, multifaceted intervention to improve blood pressure control.

Journal Article Circ Cardiovasc Qual Outcomes · November 2014 BACKGROUND: Although home blood pressure (BP) monitoring interventions have shown potential in selected populations, it is unclear whether such strategies can be generalized. We sought to determine whether a multifaceted BP control program that uses a web- ... Full text Link to item Cite

Differences in short-term versus long-term outcomes of older black versus white patients with myocardial infarction: findings from the Can Rapid Risk Stratification of Unstable Angina Patients Suppress Adverse Outcomes with Early Implementation of American College of Cardiology/American Heart Association Guidelines (CRUSADE).

Journal Article Circulation · August 19, 2014 BACKGROUND: Blacks are less likely than whites to receive coronary revascularization and evidence-based therapies after acute myocardial infarction, yet the impact of these differences on long-term outcomes is unknown. METHODS AND RESULTS: We linked Can Ra ... Full text Link to item Cite

Trends in outcomes among older patients with non-ST-segment elevation myocardial infarction.

Journal Article Am Heart J · January 2014 OBJECTIVES: The objective of this study is to assess trends in evidence-based therapy use and short- and long-term mortality over time among older patients with non-ST-segment elevation myocardial infarction (NSTEMI). BACKGROUND: With the prevalence of nat ... Full text Link to item Cite

Check it, change it: a community-based intervention to improve blood pressure control.

Journal Article Circ Cardiovasc Qual Outcomes · November 2013 BACKGROUND: Despite the widespread availability of effective and affordable therapies, hypertension remains this country's most significant modifiable cardiovascular risk factor. Approximately 30% to 50% of individuals with hypertension currently fail to r ... Full text Link to item Cite

Spousal depression, anxiety, and suicide after myocardial infarction.

Journal Article Eur Heart J · March 2013 AIMS: Death of a spouse from acute myocardial infarction (AMI) presents hardship, yet few studies have investigated the psychological consequences of fatal and non-fatal AMI on spouses. METHODS AND RESULTS: Several Danish national registries were linked to ... Full text Link to item Cite

Modifiable factors associated with failure to attain low-density lipoprotein cholesterol goal at 6 months after acute myocardial infarction.

Journal Article Am Heart J · January 2013 BACKGROUND: Although controversial, reducing low-density lipoprotein cholesterol (LDL-C) to target levels remains a common therapeutic goal after acute myocardial infarction (AMI). We sought to illuminate patient and provider characteristics associated wit ... Full text Link to item Cite

Check It Change It: A Community Based Hypertension Program

Journal Article CIRCULATION · November 20, 2012 Link to item Cite

Use of emergency medical service transport among patients with ST-segment-elevation myocardial infarction: findings from the National Cardiovascular Data Registry Acute Coronary Treatment Intervention Outcomes Network Registry-Get With The Guidelines.

Journal Article Circulation · July 12, 2011 BACKGROUND: Activation of emergency medical services (EMS) is critical for the early triage and treatment of patients experiencing ST-segment-elevation myocardial infarction, yet data regarding EMS use and its association with subsequent clinical care are ... Full text Link to item Cite

In-hospital major bleeding during ST-elevation and non-ST-elevation myocardial infarction care: derivation and validation of a model from the ACTION Registry®-GWTG™.

Journal Article Am J Cardiol · April 15, 2011 Bleeding, a common complication of acute myocardial infarction (AMI) treatment, is associated with worse outcomes. A contemporary model for major bleeding associated with AMI treatment can stratify patients at elevated risk for bleeding and is needed to ri ... Full text Link to item Cite

CURRENT STATUS OF SMOKE-FREE AIR LAWS IN THE UNITED STATES

Conference Journal of the American College of Cardiology · April 2011 Full text Cite

Risk adjustment for in-hospital mortality of contemporary patients with acute myocardial infarction: the acute coronary treatment and intervention outcomes network (ACTION) registry-get with the guidelines (GWTG) acute myocardial infarction mortality model and risk score.

Journal Article Am Heart J · January 2011 BACKGROUND: accurate risk adjustment is needed to guide quality improvement initiatives and research to improve care of patients with acute myocardial infarction (MI). We developed and validated a model to predict the risk of in-hospital mortality for cont ... Full text Link to item Cite

"Reality surgery"--a research ethics perspective on the live broadcast of surgical procedures.

Journal Article J Surg Educ · 2011 In recent years, the live broadcasting of medical and surgical procedures has gained worldwide popularity. While the practice has appropriately been met with concerns for patient safety and privacy, many physicians tout the merits of real time viewing as a ... Full text Link to item Cite

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Journal Article Rev Esp Cardiol · October 2010 Full text Link to item Cite

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Conference Rev Esp Cardiol (Engl Ed) · 2010 Full text Link to item Cite

How to Minimize Contrast Nephropathy

Journal Article · March 17, 2009 Full text Cite

Anabolic steroids, acute myocardial infarction and polycythemia: a case report and review of the literature.

Journal Article Vasc Health Risk Manag · 2008 The association between testosterone-replacement therapy and cardiovascular risk remains unclear with most reports suggesting a neutral or possibly beneficial effect of the hormone in men and women. However, several cardiovascular complications including h ... Full text Link to item Cite

Diabetic cardiomyopathy

Journal Article Cardiology Review · January 1, 2007 Diabetic cardiomyopathy is a clinical condition characterized by altered myocardial function in the absence of coronary artery disease, hypertension, and valvular or congenital heart disease. Patients with this condition exhibit changes in cardiac structur ... Cite