Gustavo C. Rodriguez
Adjunct Associate Professor of Obstetrics and Gynecology
I am focussing my academic efforts in the laboratory, where experiments are being performed designed to elucidate the molecular biology of the metastatic process in epithelial ovarian cancer. We have been able to develop some important insights regarding the metastatic capability of both normal ovarian epithelial cells and epithelial cancer cells and have learned that one of the processes involved in the malignant transformation of the ovarian epithelium is an adverse response to certain growth factors such as transforming growth factor beta. Transforming growth factor beta inhibits the proliferation of normal ovarian epithelium and inhibits its invasive behavior, whereas, in ovarian cancer cells transforming growth factor beta enhances invasiveness. We have a series of experiments planned to continue to elucidate the regulation of the metastatic process in epithelial ovarian cancer cells.
In addition, we are performing experiments intended to elucidate the molecular basis for the protective action of oral contraceptives against the development of epithelial ovarian carcinoma.
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