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Rory Henderson

Associate Professor in Medicine
Medicine, Duke Human Vaccine Institute
2 Genome Ct, MSRB 2, Durham, NC 27710
2 Genome Ct, MSRB 2, Durham, NC 27710


Dr. Rory Henderson is an assistant professor in Medicine at Duke University, the head of molecular modeling and simulation in the Division of Structural Biology at the Duke Human Vaccine Institute, and the Project 1 lead for the Duke Center for HIV Structural Biology (DCHSB).

Dr. Henderson’s lab focuses on understanding how the dynamics of macromolecules of the immune system and its antigenic targets determine the immune response to infection and how these dynamics can be manipulated to guide the selection of a favorable antibody response. We utilize a diverse computational and experimental tool set to interrogate key pathogen and antibody dynamics and use rational design principles to design immunogens and probe putative functional mechanisms.  

With Dr. Henderson’s background in molecular modeling and simulation along with biochemical and cryo-electron microscopy (cryo-EM) techniques, he and his lab investigate these details at high spatial and temporal resolution. Together, these methods provide a promising approach toward accelerating the design and characterization of the next generation of vaccine immunogens.

Current Appointments & Affiliations

Associate Professor in Medicine · 2024 - Present Medicine, Duke Human Vaccine Institute, Medicine
Member of the Duke Human Vaccine Institute · 2024 - Present Duke Human Vaccine Institute, Institutes and Centers

Education, Training & Certifications

University of Arkansas, Fayetteville · 2016 Ph.D.