Overview
The Baugh Lab is interested in phenotypic plasticity and adaptation to starvation. We use the roundworm C. elegans for an integrative organismal approach that considers molecular mechanisms in a developmental and ecological context. We are studying how development is governed by nutrient availability, how animals survive starvation, long-term consequences of early life starvation, and multigenerational plasticity.
Current Appointments & Affiliations
Professor of Biology
·
2023 - Present
Biology,
Trinity College of Arts & Sciences
Associate Professor of Cell Biology
·
2022 - Present
Cell Biology,
Basic Science Departments
Affiliate of the Center for Genomic and Computational Biology
·
2019 - Present
Biology,
Trinity College of Arts & Sciences
Affiliate of the Duke Regeneration Center
·
2021 - Present
Duke Regeneration Center,
Basic Science Departments
Recent Publications
Early life starvation and Hedgehog-related signaling activate innate immunity downstream of daf-18/PTEN and lin-35/Rb causing developmental abnormalities in adult C. elegans
Preprint · March 5, 2025 Full text CiteDAF-18/PTEN protects LIN-35/Rb from CLP-1/CAPN-mediated cleavage to promote starvation resistance.
Preprint · February 21, 2025 Full text Link to item CiteDevelopmental and conditional regulation of DAF-2/INSR ubiquitination in Caenorhabditis elegans.
Journal Article G3 (Bethesda, Md.) · January 2025 Insulin/IGF signaling (IIS) regulates developmental and metabolic plasticity. Conditional regulation of insulin-like peptide expression and secretion promotes different phenotypes in different environments. However, IIS can also be regulated by other, less ... Full text CiteRecent Grants
NSF-SNSF: Molecular Mechanism of a Life-History Tradeoff between Growth and Survival
ResearchPrincipal Investigator · Awarded by National Science Foundation · 2024 - 2027Training Program in Developmental and Stem Cell Biology
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2001 - 2027Natural variation in C. elegans responses to environmental pollution
FellowshipPrincipal Investigator · Awarded by National Institute of Environmental Health Sciences · 2023 - 2026View All Grants
Education, Training & Certifications
Harvard University ·
2004
Ph.D.
University of Georgia ·
1997
B.S.