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Samuel Jarrod Francis

Assistant Professor of Emergency Medicine
Emergency Medicine

Current Duke Appointments & Affiliations


Assistant Professor of Emergency Medicine · 2021 - Present Emergency Medicine, Clinical Science Departments

Recent Scholarly Works


The influence of nuclear antigen form on complement activation by systemic lupus erythematosus antinuclear antibody immune complexes determined by a novel immunocapture assay.

Journal article J Immunol · April 15, 2026 Systemic lupus erythematosus (SLE) is a systemic autoimmune disease in which immune complexes (ICs) consisting of antinuclear autoantibodies (ANAs) and nuclear antigens induce complement activation and contribute to disease pathogenesis. The impact of anti ... Full text Link to item Cite

An Aptamer-Based EXACT Anticoagulant as a Sustainable, Animal-Free Alternative to Unfractionated Heparin.

Journal article Adv Sci (Weinh) · January 2026 Unfractionated heparin (UFH), designated as an essential medicine by the World Health Organization (WHO), is indispensable in cardiac surgery and various clinical applications. However, its production depends on the farming of over a billion large animals ... Full text Link to item Cite

Targeting PIEZO1-TMEM16F Coupling to Mitigate Sickle Cell Disease Complications.

Journal article Am J Hematol · December 2025 A deeper understanding of sickle cell disease (SCD) pathophysiology is critical for identifying novel therapeutic targets. A hallmark of SCD is abnormal phosphatidylserine (PS) exposure on sickle red blood cells (RBCs), which contributes to anemia, thrombo ... Full text Open Access Link to item Cite
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Recent Grants


Sysmex CN-6000 - D-dimer Studies for VTE Exclusion Claim

Clinical TrialPrincipal Investigator · Awarded by Sysmex America, Inc. · 2025 - 2030

An Examination of a Novel Fluorescence Assay in the Diagnosis of Heparin Induced Thrombocytopenia

ResearchPrincipal Investigator · Awarded by North Carolina Biotechnology Center · 2022 - 2023

Platelet Kinetics in Acute Thrombus Formation in Healthy and VTE Patients

FellowshipPrincipal Investigator · Awarded by Society for Academic Emergency Medicine · 2019 - 2022

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Education


Indiana University, School of Medicine · 2011 M.D.
University of Notre Dame · 2007 B.S.