Recent Publications
Lysosomal swelling triggers LRRK2 activity.
Preprint · December 12, 2025 Full text Link to item CiteLRRK2 kinase-mediated accumulation of lysosome-associated phospho-Rabs in tauopathies and synucleinopathies.
Journal Article Acta Neuropathol · October 23, 2025 Parkinson's disease (PD) pathogenic mutations in leucine-rich repeat kinase 2 (LRRK2) are associated with endolysosomal dysfunction across cell types, and carriers of LRRK2 mutations variably present with phosphorylated tau and α-synuclein deposits in post ... Full text Link to item CiteLRRK2 interactions with microtubules are independent of LRRK2-mediated Rab phosphorylation.
Journal Article EMBO Rep · July 2025 Deregulated microtubules are common defects associated with neurodegenerative diseases. Recent cryo-electron microscopy studies in cell lines overexpressing Parkinson's disease-associated LRRK2 suggest microtubule surfaces may regulate kinase activity by s ... Full text Link to item CiteRecent Grants
Characterization of LRRK2 KO rats
ResearchResearch Assistant · Awarded by Michael J. Fox Foundation for Parkinson's Research · 2025 - 2026Mechanisms of LRRK2 Mediated Neurotoxicity
ResearchResearch Assistant · Awarded by National Institute of Neurological Disorders and Stroke · 2018 - 2026Pharmacologically targeting LRRK2 for the amelioration of tau aggregation and neurotoxicity
ResearchResearch Assistant · Awarded by Edward N. & Della L. Thome Memorial Foundation · 2024 - 2026View All Grants