Recent Publications
Mouse α-synuclein fibrils are structurally and functionally distinct from human fibrils associated with Lewy body diseases.
Journal Article Sci Adv · November 2024 The intricate process of α-synuclein aggregation and fibrillization holds pivotal roles in Parkinson's disease (PD) and multiple system atrophy (MSA). While mouse α-synuclein can fibrillize in vitro, whether these fibrils commonly used in research to induc ... Full text Link to item CiteSingle molecule array measures of LRRK2 kinase activity in serum link Parkinson's disease severity to peripheral inflammation.
Journal Article bioRxiv · April 17, 2024 BACKGROUND: LRRK2-targeting therapeutics that inhibit LRRK2 kinase activity have advanced to clinical trials in idiopathic Parkinson's disease (iPD). LRRK2 phosphorylates Rab10 on endolysosomes in phagocytic cells to promote some types of immunological res ... Full text Link to item CiteAnionic nanoplastic contaminants promote Parkinson's disease-associated α-synuclein aggregation.
Journal Article Sci Adv · November 15, 2023 Recent studies have identified increasing levels of nanoplastic pollution in the environment. Here, we find that anionic nanoplastic contaminants potently precipitate the formation and propagation of α-synuclein protein fibrils through a high-affinity inte ... Full text Link to item CiteRecent Grants
Mechanisms of LRRK2 Mediated Neurotoxicity
ResearchResearch Assistant · Awarded by National Institutes of Health · 2018 - 2026Pharmacologically targeting LRRK2 for the amelioration of tau aggregation and neurotoxicity
ResearchResearch Assistant · Awarded by Edward N. & Della L. Thome Memorial Foundation · 2024 - 2026View All Grants