Scholars@Duke
Sandra Kikano

Sandra Kikano

Assistant Professor of Pediatrics
Pediatrics, Cardiology

Selected Publications

Cardiac magnetic resonance assessment of acute rejection and cardiac allograft vasculopathy in pediatric heart transplant.

Journal Article The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · May 2024 BackgroundIn pediatric heart transplant (PHT), cardiac catheterization with endomyocardial biopsy (EMB) is standard for diagnosing acute rejection (AR) and cardiac allograft vasculopathy (CAV) but is costly and invasive.ObjectivesTo evalu ... Full text Cite

Postoperative Morbidity and Interstage Hemodynamics Following Stage I Palliation in Patients with Turner Syndrome and Hypoplastic Left Heart Syndrome.

Journal Article Pediatr Cardiol · February 2024 BACKGROUND: Turner syndrome (TS) is associated with left-sided cardiac lesions, including hypoplastic left heart syndrome (HLHS). Mortality as high as 80-90% has been reported following stage I single-ventricle palliation (S1P) in patients with TS and HLHS ... Full text Link to item Cite

A rare case of isolated right atrial enlargement and TBX5 mutation associated with Holt-Oram syndrome.

Journal Article Prenat Diagn · July 2023 Holt-Oram syndrome or atriodigital dysplasia is commonly associated with cardiac malformations, most often with defects of the muscular septum. We describe the case of a fetus referred for fetal cardiology evaluation in the setting of right atrial enlargem ... Full text Link to item Cite

Reference data for left ventricular filling and atrial function in children using cardiovascular magnetic resonance.

Journal Article J Cardiovasc Magn Reson · June 12, 2023 BACKGROUND: Diastolic dysfunction is associated with morbidity and mortality in multiple pediatric disease processes. Cardiovascular magnetic resonance (CMR) provides a non-invasive method of studying left ventricular (LV) diastolic dysfunction through the ... Full text Link to item Cite

Association of cardiovascular magnetic resonance diastolic indices with arrhythmia in repaired Tetralogy of Fallot.

Journal Article J Cardiovasc Magn Reson · March 13, 2023 BACKGROUND: Patients with repaired Tetralogy of Fallot (rTOF) experience a high burden of long-term morbidity, particularly arrhythmias. Cardiovascular magnetic resonance (CMR) is routinely used to assess ventricular characteristics but the relationship be ... Full text Link to item Cite

Association between nitric oxide synthase 3 genetic variant and acute kidney injury following pediatric cardiac surgery.

Journal Article Am Heart J · December 2022 BACKGROUND: Acute kidney injury (AKI) complicates 30% to 50% of cardiac surgeries in pediatric patients. Genetic variants that affect renal blood flow and inflammation have been associated with AKI after cardiac surgery in diverse populations of adults but ... Full text Link to item Cite

Precision Medicine in Pediatric Cardiology.

Journal Article Pediatr Ann · October 2022 Precision medicine is a developing strategy for individualized treatment of a wide range of diseases. Congenital heart disease is the most common of all congenital defects and carries a high degree of variability in outcomes because of unidentified causes. ... Full text Link to item Cite

Transient fetal atrioventricular block: A series of four cases and approach to management.

Journal Article J Cardiovasc Electrophysiol · October 2022 INTRODUCTION: Fetal atrioventricular block (AVB) is a failure of conduction from atria to ventricles. Immune- and nonimmune-mediated forms occur, especially in association with congenital heart disease. Second-degree (2°) AVB may be reversible with dexamet ... Full text Link to item Cite

The Association of Fetal Congenital Cardiac Defects and Placental Vascular Malperfusion.

Journal Article Pediatr Dev Pathol · 2021 OBJECTIVES: Abnormal early angiogenesis appears to impact both placental disorders and fetal congenital heart defects (CHD). We sought to assess the association of placental perfusion defects (PPD) and fetal (CHD). METHODS: Singleton pregnancies with isola ... Full text Link to item Cite

Appropriate use of echocardiography for palpitations in paediatric cardiology clinics.

Journal Article Cardiol Young · January 2021 OBJECTIVES: Identify diagnostic yield and frequency of echocardiograms for palpitation-related indications at outpatient paediatric cardiology clinics in relation to the 2014 ACC/AAP/AHA/ASE/HRS/SCAI/SCCT/SCMR/SOPE appropriate use criteria for Initial Tran ... Full text Link to item Cite

Serial block face-scanning electron microscopy: a method to study retinal degenerative phenotypes.

Journal Article Curr Protoc Mouse Biol · December 11, 2014 Retinal degenerative conditions can vary in their clinical features and often present with subtle phenotypic features before the onset of clinically overt disease. To capture these isolated events that precipitate disease, large representative areas of the ... Full text Link to item Cite

Sequencing from dried blood spots in infants with "false positive" newborn screen for MCAD deficiency.

Journal Article Mol Genet Metab · January 2013 BACKGROUND: Newborn screening (NBS) for medium chain acyl-CoA dehydrogenase deficiency (MCADD), one of the most common disorders identified, uses measurement of octanoylcarnitine (C8) from dried blood spots. In the state of Ohio, as in many places, primary ... Full text Link to item Cite