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Journal Article Hum Genet · February 2015 We previously identified a low-frequency (1.1 %) coding variant (G45R; rs200573126) in the adiponectin gene (ADIPOQ) which was the basis for a multipoint microsatellite linkage signal (LOD = 8.2) for plasma adiponectin levels in Hispanic families. We have ... Full text Link to item Cite

Erratum to Empirical characteristics of family-based linkage to a complex trait: the ADIPOQ region and adiponectin levels (Hum Genet, (2014), 10.1007/s00439-014-1511-8)

Journal Article Human Genetics · January 13, 2015 Full text Cite

Estimating the contributions of rare and common genetic variations and clinical measures to a model trait: adiponectin.

Journal Article Genet Epidemiol · January 2013 Common genetic variation frequently accounts for only a modest amount of interindividual variation in quantitative traits and complex disease susceptibility. Circulating adiponectin, an adipocytokine implicated in metabolic disease, is a model for assessin ... Full text Link to item Cite

Association between ADIPOQ SNPs with plasma adiponectin and glucose homeostasis and adiposity phenotypes in the IRAS Family Study.

Journal Article Mol Genet Metab · December 2012 CONTEXT: Adiponectin is an adipocytokine associated with a variety of metabolic traits. These associations in human studies, in conjunction with functional studies in model systems, have implicated adiponectin in multiple metabolic processes. OBJECTIVE: We ... Full text Link to item Cite

Genetic risk assessment of type 2 diabetes-associated polymorphisms in African Americans.

Journal Article Diabetes Care · February 2012 OBJECTIVE: Multiple single nucleotide polymorphisms (SNPs) associated with type 2 diabetes (T2D) susceptibility have been identified in predominantly European-derived populations. These SNPs have not been extensively investigated for individual and cumulat ... Full text Link to item Cite

A genome-wide association search for type 2 diabetes genes in African Americans.

Journal Article PLoS One · 2012 African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African Ameri ... Full text Link to item Cite

A genome-wide association study for diabetic nephropathy genes in African Americans.

Journal Article Kidney Int · March 2011 A genome-wide association study was performed using the Affymetrix 6.0 chip to identify genes associated with diabetic nephropathy in African Americans. Association analysis was performed adjusting for admixture in 965 type 2 diabetic African American pati ... Full text Link to item Cite

Resequencing and analysis of variation in the TCF7L2 gene in African Americans suggests that SNP rs7903146 is the causal diabetes susceptibility variant.

Journal Article Diabetes · February 2011 OBJECTIVE: Variation in the transcription factor 7-like 2 (TCF7L2) locus is associated with type 2 diabetes across multiple ethnicities. The aim of this study was to elucidate which variant in TCF7L2 confers diabetes susceptibility in African Americans. RE ... Full text Link to item Cite

Molecular basis of a linkage peak: exome sequencing and family-based analysis identify a rare genetic variant in the ADIPOQ gene in the IRAS Family Study.

Journal Article Hum Mol Genet · October 15, 2010 Family-based linkage analysis has been a powerful tool for identification of genes contributing to traits with monogenic patterns of inheritance. These approaches have been of limited utility in identification of genes underlying complex traits. In contras ... Full text Link to item Cite