Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., University of North Carolina - Chapel Hill 2007
  • B.A., Macalester College 2001
• Expertise
• 

  Subject Headings

  • Muser Mentor
• Research
• 

  Selected Grants

  • Duke Preparing Research Scholars in Biomedical Sciences- Post-Baccalaureate Research Education Program awarded by National Institutes of Health 2022 - 2027
  • Training Program in Developmental and Stem Cell Biology awarded by National Institutes of Health 2001 - 2027
  • Cell and Molecular Biology Training Program awarded by National Institutes of Health 2021 - 2026
  • Genetic and Genomics Training Grant awarded by National Institutes of Health 2020 - 2025
  • Pharmacological Sciences Training Grant awarded by National Institutes of Health 2020 - 2025
  • Identifying the molecular networks regulating cilium assembly and signaling awarded by National Institutes of Health 2019 - 2024
  • Uncovering a novel role for primary cilia in Eph/Ephrin signaling in neurons awarded by Brain Research Foundation 2022 - 2023
  • Assessment of TTBK2 inhibition by a TTBK-selective kinase inhibitor and identification of TTBK2 substrates awarded by Arvinas Inc. 2022
  • Defining biochemical mechanisms of dominant interference by disease-causing variants of TTBK2 awarded by National Institutes of Health 2020 - 2022
  • Super-resolution Imaging via Multiple Modalities with the Zeiss Elyra 7 awarded by National Institutes of Health 2020 - 2021
  • Genetics Training Grant awarded by National Institutes of Health 1979 - 2020
  • Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
  • Pharmacological Sciences Training Program awarded by National Institutes of Health 1975 - 2020
  • Pharmacology Industry Internships for Ph.D. Students awarded by American Society for Pharmacology and Experimental Therapeutics 2017 - 2019
  • Characterizing the role of TTBK proteins in ciliogenesis and neural function awarded by National Institutes of Health 2013 - 2018
• 

  External Relationships

  • Arvinas
  • Google, Inc.
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Cilleros-Rodriguez, Dario, Raquel Martin-Morales, Pablo Barbeito, Abhijit Deb Roy, Abdelhalim Loukil, Belen Sierra-Rodero, Gonzalo Herranz, et al. “Multiple ciliary localization signals control INPP5E ciliary targeting.” Elife 11 (September 5, 2022). https://doi.org/10.7554/eLife.78383.
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    • Loukil, Abdelhalim, Chloe Barrington, and Sarah C. Goetz. “A complex of distal appendage-associated kinases linked to human disease regulates ciliary trafficking and stability.” Proc Natl Acad Sci U S A 118, no. 16 (April 20, 2021). https://doi.org/10.1073/pnas.2018740118.
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    • Bowie, Emily, and Sarah C. Goetz. “TTBK2 and primary cilia are essential for the connectivity and survival of cerebellar Purkinje neurons.” Elife 9 (January 14, 2020). https://doi.org/10.7554/eLife.51166.
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    • Bowie, Emily, Ryan Norris, Kathryn V. Anderson, and Sarah C. Goetz. “Spinocerebellar ataxia type 11-associated alleles of Ttbk2 dominantly interfere with ciliogenesis and cilium stability.” Plos Genet 14, no. 12 (December 2018): e1007844. https://doi.org/10.1371/journal.pgen.1007844.
       Full Text  Open Access Copy  Link to Item
    • Goetz, Sarah C., Fiona Bangs, Chloe L. Barrington, Nicholas Katsanis, and Kathryn V. Anderson. “The Meckel syndrome- associated protein MKS1 functionally interacts with components of the BBSome and IFT complexes to mediate ciliary trafficking and hedgehog signaling.” Plos One 12, no. 3 (2017): e0173399. https://doi.org/10.1371/journal.pone.0173399.
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    • Goetz, Sarah C., Karel F. Liem, and Kathryn V. Anderson. “The spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesis.” Cell 151, no. 4 (November 9, 2012): 847–58. https://doi.org/10.1016/j.cell.2012.10.010.
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    • Goetz, Sarah C., and Kathryn V. Anderson. “The primary cilium: a signalling centre during vertebrate development.” Nat Rev Genet 11, no. 5 (May 2010): 331–44. https://doi.org/10.1038/nrg2774.
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    • Goetz, Sarah C., Polloneal J. R. Ocbina, and Kathryn V. Anderson. “The primary cilium as a Hedgehog signal transduction machine.” Methods Cell Biol 94 (2009): 199–222. https://doi.org/10.1016/S0091-679X(08)94010-3.
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    • Langdon, Yvette G., Sarah C. Goetz, Anna E. Berg, Jackie Thomas Swanik, and Frank L. Conlon. “SHP-2 is required for the maintenance of cardiac progenitors.” Development 134, no. 22 (November 2007): 4119–30. https://doi.org/10.1242/dev.009290.
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    • Goetz, Sarah C., and Frank L. Conlon. “Cardiac progenitors and the embryonic cell cycle.” Cell Cycle 6, no. 16 (August 15, 2007): 1974–81. https://doi.org/10.4161/cc.6.16.4584.
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    • Goetz, Sarah C., Daniel D. Brown, and Frank L. Conlon. “TBX5 is required for embryonic cardiac cell cycle progression.” Development 133, no. 13 (July 2006): 2575–84. https://doi.org/10.1242/dev.02420.
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    • Brown, Daniel D., Shauna N. Martz, Olav Binder, Sarah C. Goetz, Brenda M. J. Price, Jim C. Smith, and Frank L. Conlon. “Tbx5 and Tbx20 act synergistically to control vertebrate heart morphogenesis.” Development 132, no. 3 (February 2005): 553–63. https://doi.org/10.1242/dev.01596.
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• Teaching & Mentoring
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  Recent Courses

  • PHARM 394: Research Independent Study 2023
  • PHARM 494: Research Independent Study 2023
  • CELLBIO 730: Stem Cell Course 2022
  • CMB 710F: Cell & Molecular Biology Module VI 2022
  • MOLCAN 730: Stem Cell Course 2022
  • PHARM 494: Research Independent Study 2022
  • PHARM 730: Stem Cell Course 2022
  • CELLBIO 730: Stem Cell Course 2021
  • CMB 710B: Cell & Molecular Biology Module II 2021
  • MOLCAN 730: Stem Cell Course 2021
  • PHARM 494: Research Independent Study 2021
  • PHARM 730: Stem Cell Course 2021

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