Scholars@Duke
Sarah Rapisardo

Sarah Rapisardo

Assistant Professor of Pathology
Pathology
sarah.horn@duke.edu
Box 3673 Med Ctr, 2351 Erwin Road, Room 0213A Wadsworth, Durham, NC 27705
2351 Erwin Rd., Room 0213D, Wadsworth Building, Durham, NC 27705

Selected Publications

Chronic Myeloid Leukemia Following Treatment for Primary Neoplasms or Other Medical Conditions.

Journal Article Am J Clin Pathol · July 31, 2018 OBJECTIVES: Therapy-related chronic myeloid leukemia (CML) has been reported, but its clinical presentation and pathologic features have not yet been well characterized. METHODS: Twenty-one cases of CML following treatment for primary diseases were collect ... Full text Link to item Cite

Composite lymphoma of follicular B-cell and peripheral T-cell types with distinct zone distribution in a 75-year-old male patient: a case study.

Journal Article Hum Pathol · June 2018 Composite lymphoma of T-/B-cell type is rare, and follicular lymphoma composite with peripheral T-cell lymphoma (PTCL) has not previously been reported. We report such a case with both neoplastic components displaying a unique zone of distribution. A 75-ye ... Full text Link to item Cite

Looking beyond the exome: a phenotype-first approach to molecular diagnostic resolution in rare and undiagnosed diseases.

Journal Article Genet Med · April 2018 PurposeTo describe examples of missed pathogenic variants on whole-exome sequencing (WES) and the importance of deep phenotyping for further diagnostic testing.MethodsGuided by phenotypic information, three children with negative WES underwent targeted sin ... Full text Open Access Link to item Cite

The deubiquitinating enzyme DUBAI stabilizes DIAP1 to suppress Drosophila apoptosis.

Journal Article Cell Death Differ · April 2014 Deubiquitinating enzymes (DUBs) counteract ubiquitin ligases to modulate the ubiquitination and stability of target signaling molecules. In Drosophila, the ubiquitin-proteasome system has a key role in the regulation of apoptosis, most notably, by controll ... Full text Link to item Cite

The evolving picture of microdeletion/microduplication syndromes in the age of microarray analysis: variable expressivity and genomic complexity.

Journal Article Clin Lab Med · December 2011 Several new microdeletion and microduplication syndromes have been discovered in a genotype-first approach. Many of these disorders are caused by nonallelic homologous recombination between blocks of segmental duplication. The authors describe 9 regions fo ... Full text Link to item Cite

Mitochondrial fusion is regulated by Reaper to modulate Drosophila programmed cell death.

Journal Article Cell Death Differ · October 2011 In most multicellular organisms, the decision to undergo programmed cell death in response to cellular damage or developmental cues is typically transmitted through mitochondria. It has been suggested that an exception is the apoptotic pathway of Drosophil ... Full text Open Access Link to item Cite

Regulation of mitochondrial morphology by APC/CCdh1-mediated control of Drp1 stability.

Journal Article Mol Biol Cell · April 15, 2011 Homeostatic maintenance of cellular mitochondria requires a dynamic balance between fission and fusion, and controlled changes in morphology are important for processes such as apoptosis and cellular division. Interphase mitochondria have been described as ... Full text Link to item Cite

Growth factor erv1-like modulates Drp1 to preserve mitochondrial dynamics and function in mouse embryonic stem cells.

Journal Article Mol Biol Cell · April 1, 2010 The relationship of mitochondrial dynamics and function to pluripotency are rather poorly understood aspects of stem cell biology. Here we show that growth factor erv1-like (Gfer) is involved in preserving mouse embryonic stem cell (ESC) mitochondrial morp ... Full text Open Access Link to item Cite

An essential role for the Glut1 PDZ-binding motif in growth factor regulation of Glut1 degradation and trafficking.

Journal Article Biochem J · March 1, 2009 Cell surface localization of the Glut (glucose transporter), Glut1, is a cytokine-controlled process essential to support the metabolism and survival of haemopoietic cells. Molecular mechanisms that regulate Glut1 trafficking, however, are not certain. In ... Full text Link to item Cite

Mitochondrial localization of Reaper to promote inhibitors of apoptosis protein degradation conferred by GH3 domain-lipid interactions.

Journal Article J Biol Chem · January 4, 2008 Morphological hallmarks of apoptosis result from activation of the caspase family of cysteine proteases, which are opposed by a pro-survival family of inhibitors of apoptosis proteins (IAPs). In Drosophila, disruption of IAP function by Reaper, HID, and Gr ... Full text Link to item Cite

Crossover interference on nucleolus organizing region-bearing chromosomes in Arabidopsis.

Journal Article Genetics · June 2005 In most eukaryotes, crossovers are not independently distributed along the length of a chromosome. Instead, they appear to avoid close proximity to one another--a phenomenon known as crossover interference. Previously, for three of the five Arabidopsis chr ... Full text Link to item Cite