Scholars@Duke
Sarah Jo Stephens

Sarah Jo Stephens

Assistant Professor of Radiation Oncology
Radiation Oncology
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Selected Publications

System for High-Intensity Evaluation During Radiation Therapy (SHIELD-RT): A Prospective Randomized Study of Machine Learning-Directed Clinical Evaluations During Radiation and Chemoradiation.

Journal Article J Clin Oncol · November 1, 2020 PURPOSE: Patients undergoing outpatient radiotherapy (RT) or chemoradiation (CRT) frequently require acute care (emergency department evaluation or hospitalization). Machine learning (ML) may guide interventions to reduce this risk. There are limited prosp ... Full text Link to item Cite

Evaluating for disparities in place of death for head and neck cancer patients in the United States utilizing the CDC WONDER database.

Journal Article Oral Oncol · March 2020 OBJECTIVE: Evaluate trends in place of death for patients with head and neck cancers (HNC) in the U.S. from 1999 to 2017 based on the CDC WONDER (Wide-ranging Online Data for Epidemiologic Research) database. MATERIALS/METHODS: Using patient-level data fro ... Full text Link to item Cite

Local Tumor Control and Patient Outcome Using Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma: iRECIST as a Potential Substitute for Traditional Criteria.

Journal Article AJR Am J Roentgenol · December 2019 OBJECTIVE. The purpose of this study was to investigate whether, compared with traditional criteria, the modified Response Evaluation Criteria in Solid Tumors version 1.1 for immune-based therapeutics (iRECIST) improves prediction of local tumor control an ... Full text Link to item Cite

Total Neoadjuvant Therapy (TNT) in Rectal Cancer

Journal Article Current Colorectal Cancer Reports · December 1, 2018 Purpose of Review: This review summarizes the relevant literature on the use of total neoadjuvant therapy (TNT) for patients with locally advanced rectal cancer. It highlights the most notable literature published and briefly discusses future directions. R ... Full text Cite

The role of external beam radiotherapy in the treatment of hepatocellular cancer.

Journal Article Cancer · September 1, 2018 Hepatocellular carcinoma (HCC) is increasing in incidence and mortality. Although the prognosis remains poor, long-term survival has improved from 3% in 1970 to an 18% 5-year survival rate today. This is likely because of the introduction of well tolerated ... Full text Link to item Cite

Managing Patients With Oligometastatic Non-Small-Cell Lung Cancer.

Journal Article J Oncol Pract · January 2018 Metastatic lung cancer has long been considered incurable, with the goal of treatment being palliation. However, a clinically meaningful number of these patients with limited metastases (approximately 25%) are living long term after definitive treatment to ... Full text Link to item Cite

Codon bias imposes a targetable limitation on KRAS-driven therapeutic resistance.

Journal Article Nat Commun · June 8, 2017 KRAS mutations drive resistance to targeted therapies, including EGFR inhibitors in colorectal cancer (CRC). Through genetic screens, we unexpectedly find that mutant HRAS, which is rarely found in CRC, is a stronger driver of resistance than mutant KRAS. ... Full text Link to item Cite

Myeloablative conditioning with total body irradiation for AML: Balancing survival and pulmonary toxicity.

Conference Adv Radiat Oncol · 2016 PURPOSE: The purpose of this study was to compare leukemia-free survival (LFS) and other clinical outcomes in patients with acute myelogenous leukemia who underwent a myeloablative allogeneic stem cell transplant with and without total body irradiation (TB ... Full text Open Access Link to item Cite

Long-Term Outcomes of Lobectomy for Non-Small Cell Lung Cancer After Definitive Radiation Treatment.

Journal Article Ann Thorac Surg · June 2015 BACKGROUND: Salvage surgical resection for non-small cell lung cancer (NSCLC) patients initially treated with definitive chemotherapy and radiotherapy can be performed safely, but the long-term benefits are not well characterized. METHODS: Perioperative co ... Full text Link to item Cite

Human papillomavirus tumor infection in esophageal squamous cell carcinoma.

Journal Article J Gastrointest Oncol · June 2015 The association between human papillomavirus (HPV) and esophageal squamous cell carcinoma (ESCC) has been recognized for over three decades. Recently, multiple meta-analyses have drawn upon existing literature to assess the strength of the HPV-ESCC linkage ... Full text Link to item Cite