https://orcid.org/0000-0002-0694-6388
Overview
Schuyler Melore is a postdoctoral researcher in the San Roman Lab and is interested in developing new CRISPR epigenome editing methods for studying sex chromosome aneuploidies. He holds a BA in mathematics from Williams College and a PhD in genetics and genomics from Duke University.
Current Duke Appointments & Affiliations
Postdoctoral Associate
Basic Science Departments,
School of Medicine
Recent Scholarly Works
dHyperCas12a enables multiplexed CRISPRi screens.
Journal article Nat Commun · February 12, 2026 Interactions between genes or cis-regulatory elements (CREs) underlie many biological processes. High-throughput CRISPR screens have allowed researchers to assess the impact of activation or repression of gene and regulatory elements on many phenotypes. Ho ... Full text Link to item CiteSMARCA2 is an essential and potent cofactor for a specific subset of the glucocorticoid response in A549 cells.
Journal article bioRxiv · November 14, 2025 Glucocorticoids are a widely used, potent class of anti-inflammatory drugs that modulate the expression of hundreds of genes across the genome. Although the glucocorticoid response is primarily carried out by the glucocorticoid receptor (NR3C1, a.k.a. GR), ... Full text Link to item CiteMultiplex neurodegeneration proteotoxicity platform reveals DNAJB6 promotes non-toxic FUS condensate gelation and inhibits neurotoxicity.
Journal article Nature communications · November 2025 Neurodegenerative disorders (NDDs) are a family of diseases that remain poorly treated despite their growing global health burden. To gain insight into the mechanisms and modulators of neurodegeneration, we developed a yeast-based multiplex genetic screeni ... Full text CiteRecent Grants
The Duke FUNCTION Center: Pioneering the comprehensive identification of combinatorial noncoding causes of disease
ResearchResearch Assistant · Awarded by National Human Genome Research Institute · 2020 - 2025Predicting Newborn and Childhood Adiposity: An Integrated Omics Approach
ResearchResearch Assistant · Awarded by Northwestern University · 2018 - 2025View All Grants