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Scott William Cousins

Robert Machemer, M.D. Distinguished Professor of Ophthalmology
Ophthalmology, Vitreoretinal Diseases & Surgery
Box 3802 Med Ctr, Durham, NC 27710
Wadsworth Building, Durham, NC 27710

Overview


Scott W. Cousins, M.D. is currently the Robert Machemer, M.D. Professor of Ophthalmology and Immunology, Vice Chair for Research, and Director of the Duke Center for Macular Diseases at Duke Eye Center. As Vice Chair, he oversees all basic science research as well as the Ophthalmology Site-Based Research Group, which administrates clinical research for Duke Eye Center. Dr. Cousins is also Medical Director of Hospital-Based Imaging and Procedures for Duke Eye Center.

Dr. Cousins is a retina-trained ophthalmologist who specializes in the diagnosis and treatment of macular diseases, especially age-related macular degeneration (AMD), diabetic retinopathy, and retinal vascular diseases. Dr. Cousins is active in both clinical and laboratory research. In his clinical practice, Dr. Cousins is involved in many trials and innovative therapies for the treatment of macular diseases, especially AMD and diabetic retinopathy. He has served as site PI for numerous phase1-3 clinical trials in AMD, diabetic retinopathy, and other retinal disorders. He has served as a consultant or member of data safety monitoring committees (DSMC) for numerous pharmaceutical and biotechnology startup companies.

In his scientific laboratory, Dr. Cousins pursues both NIH-funded and industry-funded research in various areas of dry and wet AMD. In particular, he is studying the role of circulating bone marrow-derived progenitors (stem cells) in contributing to wet AMD. His laboratory is attempting to develop treatments for dry macular degeneration and improving vision in eyes with wet macular degeneration. His program is also developing blood tests and new imaging technologies for the identification of patients who are at high risk for progressing into complications.

Dr. Cousins has published over 100 peer-reviewed manuscripts, book chapters, and other publications addressing topics of research or clinical care of retinal disease, especially AMD. In 2006, Dr. Cousins was awarded the prestigious Alcon Research Foundation Clinician Scientist Award. In 2008, the National Institutes of Health invited Dr. Cousins to join the National Advisory Eye Council. Dr. Cousins is also a member of the American Academy of Ophthalmology, the American Society of Retina Specialists, the Retina Society, the Association for Research in Vision and Ophthalmology, the American Association of Immunologists, and the American Medical Association.

In 2010, Dr. Cousins was named one of the “Top 34 Ophthalmologists in the United States” by Becker’s ASC Review, a leading source of business and legal news for ambulatory surgery centers. They cited his leadership of the Duke Center for Macular Diseases and his ongoing research in macular degeneration as reasons for the honor.

Current Appointments & Affiliations


Robert Machemer, M.D. Distinguished Professor of Ophthalmology · 2006 - Present Ophthalmology, Vitreoretinal Diseases & Surgery, Ophthalmology
Professor of Ophthalmology · 2005 - Present Ophthalmology, Vitreoretinal Diseases & Surgery, Ophthalmology
Professor in the Department of Immunology · 2006 - Present Integrative Immunobiology, Basic Science Departments

In the News


Published May 21, 2014
$100K Grants Promote Translational Research into Itching, Pompe Disease, and More

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Recent Publications


ReCLAIM-2: A Randomized Phase II Clinical Trial Evaluating Elamipretide in Age-related Macular Degeneration, Geographic Atrophy Growth, Visual Function, and Ellipsoid Zone Preservation.

Journal Article Ophthalmol Sci · 2025 OBJECTIVE: This study evaluated the safety and efficacy of elamipretide in dry age-related macular degeneration (AMD) with noncentral geographic atrophy (GA). DESIGN: ReCLAIM-2 was a prospective, phase II, randomized, placebo-controlled, double-masked, mul ... Full text Link to item Cite

Identifying a stable and generalizable factor structure of major depressive disorder across three large longitudinal cohorts.

Journal Article Psychiatry Res · March 2024 The Patient Health Questionnaire 9 (PHQ-9) is the current standard outpatient screening tool for measuring and tracking the nine symptoms of major depressive disorder (MDD). While the PHQ-9 was originally conceptualized as a unidimensional measure, it has ... Full text Link to item Cite

Accelerated Brain Atrophy, Microstructural Decline and Connectopathy in Age-Related Macular Degeneration.

Journal Article Biomedicines · January 10, 2024 Age-related macular degeneration (AMD) has recently been linked to cognitive impairment. We hypothesized that AMD modifies the brain aging trajectory, and we conducted a longitudinal diffusion MRI study on 40 participants (20 with AMD and 20 controls) to r ... Full text Open Access Link to item Cite
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Recent Grants


Role of Proteasome Overload in Pathogenesis of Retinitis Pigmentosa

ResearchCo-Mentor · Awarded by National Institutes of Health · 2022 - 2027

Role of Tissue Resident Macrophages in the Conventional Outflow Function

ResearchCo-Mentor · Awarded by National Institutes of Health · 2021 - 2025

Duke CTSA (TL1) Year 5

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2018 - 2024

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Education, Training & Certifications


Case Western Reserve University · 1982 M.D.
Dartmouth College · 1977 B.A.