Scholars@Duke
Scott Jeffery Denardo

Scott Jeffery Denardo

Clinical Faculty in the Department of Medicine
Medicine, Cardiology

Selected Publications

Translating proof-of-concept for platelet slip into improved antithrombotic therapeutic regimens.

Journal Article Platelets · December 2024 Platelets are central to thrombosis. Research at the intersection of biological and physical sciences provides proof-of-concept for shear rate-dependent platelet slip at vascular stenosis and near device surfaces. Platelet slip extends the observed biologi ... Full text Link to item Cite

Validated model of platelet slip at stenosis and device surfaces.

Journal Article Platelets · 2020 Platelets are central to thrombosis. However, it is unknown whether platelets slip at vascular or device surfaces. The presence of platelet slip at a surface would interrupt physical contact between the platelet and that surface, and therefore diminish adh ... Full text Link to item Cite

Baseline Hemodynamics and Response to Contrast Media During Diagnostic Cardiac Catheterization Predict Adverse Events in Heart Failure Patients.

Journal Article Circ Heart Fail · July 2016 BACKGROUND: Contrast media administered during cardiac catheterization can affect hemodynamic variables. However, little is documented about the effects of contrast on hemodynamics in heart failure patients or the prognostic value of baseline and changes i ... Full text Link to item Cite

Association of aortic stiffness and wave reflections with coronary flow reserve in women without obstructive coronary artery disease: An ancillary study from the National Heart, Lung, and Blood Institute-sponsored Women's Ischemia Syndrome Evaluation (WISE).

Journal Article Am Heart J · December 2015 BACKGROUND: Increased aortic stiffness and reduced coronary flow reserve (CFR) independently predict adverse outcomes. But information about relationships between arterial properties and CFR in subjects without obstructive coronary artery disease (CAD) is ... Full text Link to item Cite

Effects of verapamil SR and atenolol on 24-hour blood pressure and heart rate in hypertension patients with coronary artery disease: an international verapamil SR-trandolapril ambulatory monitoring substudy.

Journal Article PLoS One · 2015 Elevated nighttime blood pressure (BP) and heart rate (HR), increased BP and HR variability, and altered diurnal variations of BP and HR (nighttime dipping and morning surge) in patients with systemic hypertension are each associated with increased adverse ... Full text Link to item Cite

Arterial stiffness, wave reflection amplitude and left ventricular afterload are increased in overweight individuals

Journal Article Artery Research · September 1, 2013 Background: Reflected pressure waves from the lower body to the heart in overweight subjects return early and augment aortic systolic pressure and increase left ventricular (LV) afterload and wasted energy. Methods: Central aortic pressure waves were gener ... Full text Cite

Increased wave reflection and ejection duration in women with chest pain and nonobstructive coronary artery disease: ancillary study from the Women's Ischemia Syndrome Evaluation.

Journal Article J Hypertens · July 2013 OBJECTIVE: Wave reflections augment central aortic SBP and increase systolic pressure time integral (SPTI) thereby increasing left ventricular (LV) afterload and myocardial oxygen (MVO2) demand. When increased, such changes may contribute to myocardial isc ... Full text Link to item Cite

Detailed analysis of polymer response to delivery balloon expansion of drug-eluting stents versus bare metal stents.

Journal Article EuroIntervention · July 2013 AIMS: We sought to describe the response of the polymer surface of drug-eluting stents (DES) to delivery balloon expansion, including quantitation of any resulting detached microparticles. METHODS AND RESULTS: We expanded the US Food and Drug Administratio ... Full text Link to item Cite

Effect of phosphodiesterase type 5 inhibition on microvascular coronary dysfunction in women: a Women's Ischemia Syndrome Evaluation (WISE) ancillary study.

Journal Article Clin Cardiol · August 2011 BACKGROUND: Microvascular coronary dysfunction (MCD) is associated with symptoms and signs of ischemia, and also adverse outcomes in women without macrovascular obstructive coronary artery disease (M-CAD). Although MCD can be quantified using coronary flow ... Full text Link to item Cite

An intravascular ultrasound analysis in women experiencing chest pain in the absence of obstructive coronary artery disease: a substudy from the National Heart, Lung and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE).

Journal Article J Interv Cardiol · December 2010 AIMS: Using intravascular ultrasound (IVUS), we sought to characterize coronary morphology in women with chest pain without major epicardial obstructive coronary artery disease (CAD). We have previously observed an unexpectedly high rate of adverse outcome ... Full text Link to item Cite

Coronary revascularization strategy and outcomes according to blood pressure (from the International Verapamil SR-Trandolapril Study [INVEST]).

Journal Article Am J Cardiol · August 15, 2010 The optimal blood pressure (BP) to prevent major adverse outcomes (death, myocardial infarction, and stroke) for patients with hypertension and coronary artery disease who have undergone previous revascularization is unknown but might be influenced by the ... Full text Link to item Cite

Blood pressure and outcomes in very old hypertensive coronary artery disease patients: an INVEST substudy.

Journal Article Am J Med · August 2010 BACKGROUND: Our understanding of the growing population of very old patients (aged >or=80 years) with coronary artery disease and hypertension is limited, particularly the relationship between blood pressure and adverse outcomes. METHODS: This was a second ... Full text Link to item Cite

Tight blood pressure control and cardiovascular outcomes among hypertensive patients with diabetes and coronary artery disease.

Journal Article JAMA · July 7, 2010 CONTEXT: Hypertension guidelines advocate treating systolic blood pressure (BP) to less than 130 mm Hg for patients with diabetes mellitus; however, data are lacking for the growing population who also have coronary artery disease (CAD). OBJECTIVE: To dete ... Full text Link to item Cite

Pulse wave analysis of the aortic pressure waveform in severe left ventricular systolic dysfunction.

Journal Article Circ Heart Fail · January 2010 BACKGROUND: The effect of moderate left ventricular systolic dysfunction (LVSD) on ventricular/vascular coupling and the aortic pressure waveform (AoPW) has been well described, but the effect of severe LVSD has not. METHODS AND RESULTS: We used noninvasiv ... Full text Link to item Cite

Outcomes Among hypertensive patients with concomitant peripheral and coronary artery disease: findings from the INternational VErapamil-SR/Trandolapril STudy.

Journal Article Hypertension · January 2010 Hypertension is a common risk factor for peripheral arterial disease (PAD). Guidelines suggest treating PAD patients to a blood pressure <130/80 mm Hg; therefore, our objective was to explore whether attainment of this target blood pressure is associated w ... Full text Link to item Cite

Characteristics and outcomes of revascularized patients with hypertension: an international verapamil SR-trandolapril substudy.

Journal Article Hypertension · April 2009 Our understanding of the growing population of revascularized patients with hypertension is limited. We retrospectively analyzed the International Verapamil SR-Trandolapril Study, which randomized coronary artery disease patients with hypertension to eithe ... Full text Link to item Cite

Response to The J-point revisited

Journal Article Hypertension · May 1, 2008 Full text Cite

Effects of arterial stiffness, pulse wave velocity, and wave reflections on the central aortic pressure waveform.

Journal Article J Clin Hypertens (Greenwich) · April 2008 Brachial systolic and pulse blood pressures (BPs) are better predictors of adverse cardiovascular (CV) events than diastolic BP in individuals older than 50 years. The principal cause of increased systolic and pulse BP is increased stiffness of the elastic ... Full text Link to item Cite

Effectiveness and safety of reduced-dose enoxaparin in non-ST-segment elevation acute coronary syndrome followed by antiplatelet therapy alone for percutaneous coronary intervention.

Journal Article Am J Cardiol · November 1, 2007 Adjunctive pharmacotherapy for stabilizing patients with acute coronary syndrome/non-ST-segment elevation myocardial infarction (ACS/NSTEMI) and for subsequent percutaneous coronary intervention (PCI) includes a combination of anticoagulant and antiplatele ... Full text Link to item Cite

Elective percutaneous coronary intervention using broad-spectrum antiplatelet therapy (eptifibatide, clopidogrel, and aspirin) alone, without scheduled unfractionated heparin or other antithrombin therapy.

Journal Article Am Heart J · January 2005 BACKGROUND: Adjunctive pharmacotherapy during percutaneous coronary intervention (PCI) has historically consisted of a regimen of antiplatelet agents accompanied by an antithrombin agent, typically unfractionated heparin. Paradoxically, unfractionated hepa ... Full text Link to item Cite

Efficacy and safety of minimal dose (< or =1,000 units) unfractionated heparin with abciximab in percutaneous coronary intervention.

Journal Article Am J Cardiol · January 1, 2003 Abciximab decreases adverse cardiac ischemic events, and in some subgroups, decreases the need for revascularization after percutaneous coronary intervention (PCI). However, abciximab may cause bleeding complications and thrombocytopenia after PCI. We hypo ... Full text Link to item Cite

Accuracy of Doppler catheter measurements: effect of inhomogeneous beam power distribution on mean and peak velocity.

Journal Article J Am Coll Cardiol · February 1997 OBJECTIVES: We sought to determine the effect of inhomogeneous distribution of beam power produced by Doppler catheters on measurements of mean and peak velocity of coronary blood flow. BACKGROUND: Measurements of mean velocity of coronary blood flow by Do ... Full text Link to item Cite

Safety and efficacy of extended urokinase infusion plus stent deployment for treatment of obstructed, older saphenous vein grafts.

Journal Article Am J Cardiol · October 15, 1995 This study was designed to determine the safety and efficacy of extended, continuous infusion of urokinase plus stent deployment to treat older saphenous vein bypass grafts obstructed by both thrombus and atheromatous material. Thirty patients with angiogr ... Full text Link to item Cite

Angioscopic versus angiographic detection of thrombus during coronary interventional procedures.

Journal Article Am J Cardiol · June 1, 1995 The purpose of this study was to compare angiography and angioscopy for the detection of thrombus during coronary interventional procedures. The diagnosis of coronary thrombus has important clinical implications. Angioscopy can directly visualize the coron ... Full text Link to item Cite

Analysis of pulsed wave Doppler ultrasound spectra obtained from a model intracoronary catheter.

Journal Article IEEE Trans Biomed Eng · July 1994 Abnormal arterial blood flow patterns have been implicated in the evolution of various vascular disease processes. Intravascular ultrasound techniques using the pulsed wave Doppler catheter offer the opportunity to characterize these abnormal flow patterns ... Full text Link to item Cite

Coronary angioscopy before and after stent deployment

Journal Article Proceedings of SPIE the International Society for Optical Engineering · December 1, 1993 Coronary angioscopy was used in an attempt to visualize the internal architecture of cardiac vessels before and after deployment of Palmaz-Schatz stents in 50 patients. The vessel was successfully visualized in 48 (96%) of these patients. In 24 patients, a ... Cite

Effect of stenosis inlet geometry on shear rates of blood flow in the upstream region.

Journal Article Am Heart J · February 1993 Abnormal shear rates of blood flow have been implicated in the processes of thrombosis, atherosclerosis, and restenosis after angioplasty. However, no study has quantitated the effect of stenosis inlet geometry on the shear rates in the region upstream to ... Full text Link to item Cite

Differentiation of abnormal blood flow patterns in coronary arteries based on Doppler catheter recordings.

Journal Article Angiology · September 1991 Abnormal arterial blood flow patterns have been implicated as etiologic factors in thrombosis and atherosclerosis. Intravascular pulsed Doppler ultrasound techniques with fast-Fourier transform analysis offer the opportunity to measure these abnormalities. ... Full text Link to item Cite

Is the adaptation of right ventricular refractoriness to an abrupt increase in heart rate impaired in chronic heart failure?

Journal Article Am Heart J · March 1989 Chronic heart failure is associated with a high risk of ventricular arrhythmias and sudden death, although the mechanisms leading to these arrhythmias are not fully understood. To determine if the adaptation of ventricular refractoriness to an abrupt incre ... Full text Link to item Cite

Efficacy of intensive care for bone marrow transplant patients with respiratory failure.

Journal Article Crit Care Med · January 1989 We reviewed the ICU courses of 50 bone marrow transplant recipients treated for respiratory problems. Seven of nine postoperative patients survived compared to one of 40 patients with progressive interstitial pneumonia. Nonsurvivors accounted for 94% of th ... Full text Link to item Cite

Feasibility, reliability, and advantage of utilizing low contrast dose digital subtraction ventriculography in a conventional catheterization laboratory.

Journal Article Am Heart J · September 1985 Ventriculography was performed with conventional biplane fluoroscopic equipment; a 1:4 dilution of contrast medium in a standard injectate volume was delivered by a power injector. The biplane images were acquired with two video tape recorders and enhanced ... Full text Link to item Cite