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Scott Robertson

Assistant Professor of Radiology
Radiology
2424 Erwin Rd Suite 302, DUMC 2731, Durham, NC 27705

Selected Publications


Optimized quantitative mapping of cardiopulmonary oscillations using hyperpolarized 129 Xe gas exchange MRI: Digital phantoms and clinical evaluation in CTEPH.

Journal Article Magn Reson Med · April 2024 PURPOSE: The interaction between 129 Xe atoms and pulmonary capillary red blood cells provides cardiogenic signal oscillations that display sensitivity to precapillary and postcapillary pulmonary hypertension. Recently, such oscillations have been spatiall ... Full text Link to item Cite

Pulsed wave Doppler ultrasound: Accuracy, variability, and impact of acquisition parameters on flow measurements.

Journal Article Med Phys · November 2023 BACKGROUND: Pulsed wave Doppler ultrasound is a useful modality for assessing vascular health as it quantifies blood flow characteristics. To facilitate accurate diagnosis, accuracy and consistency of this modality should be assessed through Doppler qualit ... Full text Link to item Cite

Optimization of non-endorectal prostate MR image quality using PI-QUAL: A multidisciplinary team approach.

Journal Article Eur J Radiol · September 2023 PURPOSE: To evaluate the utility of the PI-QUAL score in assessing protocol changes aimed to improve image quality from a non-endorectal coil prostate MR imaging protocol during a 9-month quality improvement (QI) project and to quantify the inter-reader ag ... Full text Link to item Cite

Contrast-Enhanced In-Phase Dixon Sequence: Impact on Biopsy Clip Detection on Breast MRI.

Journal Article AJR Am J Roentgenol · March 2023 BACKGROUND. Identification of breast biopsy clips using conventional MRI sequences may be challenging. A contrast-enhanced in-phase Dixon sequence may have greater conspicuity for areas of susceptibility compared with standard clinical sequences. OBJECTIVE ... Full text Link to item Cite

View-sharing for 4D magnetic resonance imaging with randomized projection-encoding enables improvements of respiratory motion imaging for treatment planning in abdominothoracic radiotherapy.

Journal Article Phys Imaging Radiat Oncol · January 2023 BACKGROUND AND PURPOSE: The accuracy and precision of radiation therapy are dependent on the characterization of organ-at-risk and target motion. This work aims to demonstrate a 4D magnetic resonance imaging (MRI) method for improving spatial and temporal ... Full text Link to item Cite

Optimizing Diffusion Imaging Protocols for Structural Connectomics in Mouse Models of Neurological Conditions.

Journal Article Front Phys · April 2020 Network approaches provide sensitive biomarkers for neurological conditions, such as Alzheimer's disease (AD). Mouse models can help advance our understanding of underlying pathologies, by dissecting vulnerable circuits. While the mouse brain contains less ... Full text Link to item Cite

Mapping and correcting hyperpolarized magnetization decay with radial keyhole imaging.

Journal Article Magnetic resonance in medicine · July 2019 PurposeHyperpolarized (HP) media enable biomedical imaging applications that cannot be achieved with conventional MRI contrast agents. Unfortunately, quantifying HP images is challenging, because relaxation and radio-frequency pulsing generate spa ... Full text Cite

Multireader Determination of Clinically Significant Obstruction Using Hyperpolarized 129Xe-Ventilation MRI.

Journal Article AJR Am J Roentgenol · April 2019 OBJECTIVE: The objective of our study was to identify the magnitude and distribution of ventilation defect scores (VDSs) derived from hyperpolarized (HP) 129Xe-MRI associated with clinically relevant airway obstruction. MATERIALS AND METHODS: From 2012 to ... Full text Link to item Cite

A protocol for quantifying cardiogenic oscillations in dynamic 129 Xe gas exchange spectroscopy: The effects of idiopathic pulmonary fibrosis.

Journal Article NMR Biomed · January 2019 The spectral parameters of hyperpolarized 129 Xe exchanging between airspaces, interstitial barrier, and red blood cells (RBCs) are sensitive to pulmonary pathophysiology. This study sought to evaluate whether the dynamics of 129 Xe spectroscopy provide ad ... Full text Link to item Cite

A portable ventilator with integrated physiologic monitoring for hyperpolarized 129Xe MRI in rodents.

Journal Article J Magn Reson · October 2018 Hyperpolarized (HP) 129Xe MRI is emerging as a powerful, non-invasive method to image lung function and is beginning to find clinical application across a range of conditions. As clinical implementation progresses, it becomes important to translate back to ... Full text Link to item Cite

Using hyperpolarized 129Xe MRI to quantify regional gas transfer in idiopathic pulmonary fibrosis.

Journal Article Thorax · January 2018 BACKGROUND: Assessing functional impairment, therapeutic response and disease progression in patients with idiopathic pulmonary fibrosis (IPF) continues to be challenging. Hyperpolarized 129Xe MRI can address this gap through its unique capability to image ... Full text Link to item Cite

Uncovering a third dissolved-phase 129 Xe resonance in the human lung: Quantifying spectroscopic features in healthy subjects and patients with idiopathic pulmonary fibrosis.

Journal Article Magn Reson Med · October 2017 PURPOSE: The purpose of this work was to accurately characterize the spectral properties of hyperpolarized 129 Xe in patients with idiopathic pulmonary fibrosis (IPF) compared to healthy volunteers. METHODS: Subjects underwent hyperpolarized 129 Xe breath- ... Full text Link to item Cite

Novel Magnetic Resonance Imaging for Assessment of Bronchial Stenosis in Lung Transplant Recipients.

Journal Article Am J Transplant · July 2017 Bronchial stenosis in lung transplant recipients is a common disorder that adversely affects clinical outcomes. It is evaluated by spirometry, CT scanning, and bronchoscopy with significant limitations. We hypothesize that MRI using both ultrashort echo ti ... Full text Link to item Cite

Quantitative analysis of hyperpolarized 129 Xe gas transfer MRI.

Journal Article Med Phys · June 2017 PURPOSE: Hyperpolarized 129 Xe magnetic resonance imaging (MRI) using Dixon-based decomposition enables single-breath imaging of 129 Xe in the airspaces, interstitial barrier tissues, and red blood cells (RBCs). However, methods to quantitatively visualize ... Full text Link to item Cite

Establishing an accurate gas phase reference frequency to quantify 129 Xe chemical shifts in vivo.

Journal Article Magn Reson Med · April 2017 PURPOSE: 129 Xe interacts with biological media to exhibit chemical shifts exceeding 200 ppm that report on physiology and pathology. Extracting this functional information requires shifts to be measured precisely. Historically, shifts have been reported r ... Full text Link to item Cite

Three-dimensional echo-planar cine imaging of cerebral blood supply using arterial spin labeling.

Journal Article Magma (New York, N.Y.) · December 2016 ObjectiveEcho-planar imaging (EPI) with CYlindrical Center-out spatiaL Encoding (EPICYCLE) is introduced as a novel hybrid three-dimensional (3D) EPI technique. Its suitability for the tracking of a short bolus created by pseudo-continuous arteria ... Full text Cite

Optimized quantitative mapping of cardiopulmonary oscillations using hyperpolarized 129 Xe gas exchange MRI: Digital phantoms and clinical evaluation in CTEPH.

Journal Article Magn Reson Med · April 2024 PURPOSE: The interaction between 129 Xe atoms and pulmonary capillary red blood cells provides cardiogenic signal oscillations that display sensitivity to precapillary and postcapillary pulmonary hypertension. Recently, such oscillations have been spatiall ... Full text Link to item Cite

Pulsed wave Doppler ultrasound: Accuracy, variability, and impact of acquisition parameters on flow measurements.

Journal Article Med Phys · November 2023 BACKGROUND: Pulsed wave Doppler ultrasound is a useful modality for assessing vascular health as it quantifies blood flow characteristics. To facilitate accurate diagnosis, accuracy and consistency of this modality should be assessed through Doppler qualit ... Full text Link to item Cite

Optimization of non-endorectal prostate MR image quality using PI-QUAL: A multidisciplinary team approach.

Journal Article Eur J Radiol · September 2023 PURPOSE: To evaluate the utility of the PI-QUAL score in assessing protocol changes aimed to improve image quality from a non-endorectal coil prostate MR imaging protocol during a 9-month quality improvement (QI) project and to quantify the inter-reader ag ... Full text Link to item Cite

Contrast-Enhanced In-Phase Dixon Sequence: Impact on Biopsy Clip Detection on Breast MRI.

Journal Article AJR Am J Roentgenol · March 2023 BACKGROUND. Identification of breast biopsy clips using conventional MRI sequences may be challenging. A contrast-enhanced in-phase Dixon sequence may have greater conspicuity for areas of susceptibility compared with standard clinical sequences. OBJECTIVE ... Full text Link to item Cite

View-sharing for 4D magnetic resonance imaging with randomized projection-encoding enables improvements of respiratory motion imaging for treatment planning in abdominothoracic radiotherapy.

Journal Article Phys Imaging Radiat Oncol · January 2023 BACKGROUND AND PURPOSE: The accuracy and precision of radiation therapy are dependent on the characterization of organ-at-risk and target motion. This work aims to demonstrate a 4D magnetic resonance imaging (MRI) method for improving spatial and temporal ... Full text Link to item Cite

Optimizing Diffusion Imaging Protocols for Structural Connectomics in Mouse Models of Neurological Conditions.

Journal Article Front Phys · April 2020 Network approaches provide sensitive biomarkers for neurological conditions, such as Alzheimer's disease (AD). Mouse models can help advance our understanding of underlying pathologies, by dissecting vulnerable circuits. While the mouse brain contains less ... Full text Link to item Cite

Mapping and correcting hyperpolarized magnetization decay with radial keyhole imaging.

Journal Article Magnetic resonance in medicine · July 2019 PurposeHyperpolarized (HP) media enable biomedical imaging applications that cannot be achieved with conventional MRI contrast agents. Unfortunately, quantifying HP images is challenging, because relaxation and radio-frequency pulsing generate spa ... Full text Cite

Multireader Determination of Clinically Significant Obstruction Using Hyperpolarized 129Xe-Ventilation MRI.

Journal Article AJR Am J Roentgenol · April 2019 OBJECTIVE: The objective of our study was to identify the magnitude and distribution of ventilation defect scores (VDSs) derived from hyperpolarized (HP) 129Xe-MRI associated with clinically relevant airway obstruction. MATERIALS AND METHODS: From 2012 to ... Full text Link to item Cite

A protocol for quantifying cardiogenic oscillations in dynamic 129 Xe gas exchange spectroscopy: The effects of idiopathic pulmonary fibrosis.

Journal Article NMR Biomed · January 2019 The spectral parameters of hyperpolarized 129 Xe exchanging between airspaces, interstitial barrier, and red blood cells (RBCs) are sensitive to pulmonary pathophysiology. This study sought to evaluate whether the dynamics of 129 Xe spectroscopy provide ad ... Full text Link to item Cite

A portable ventilator with integrated physiologic monitoring for hyperpolarized 129Xe MRI in rodents.

Journal Article J Magn Reson · October 2018 Hyperpolarized (HP) 129Xe MRI is emerging as a powerful, non-invasive method to image lung function and is beginning to find clinical application across a range of conditions. As clinical implementation progresses, it becomes important to translate back to ... Full text Link to item Cite

Using hyperpolarized 129Xe MRI to quantify regional gas transfer in idiopathic pulmonary fibrosis.

Journal Article Thorax · January 2018 BACKGROUND: Assessing functional impairment, therapeutic response and disease progression in patients with idiopathic pulmonary fibrosis (IPF) continues to be challenging. Hyperpolarized 129Xe MRI can address this gap through its unique capability to image ... Full text Link to item Cite

Uncovering a third dissolved-phase 129 Xe resonance in the human lung: Quantifying spectroscopic features in healthy subjects and patients with idiopathic pulmonary fibrosis.

Journal Article Magn Reson Med · October 2017 PURPOSE: The purpose of this work was to accurately characterize the spectral properties of hyperpolarized 129 Xe in patients with idiopathic pulmonary fibrosis (IPF) compared to healthy volunteers. METHODS: Subjects underwent hyperpolarized 129 Xe breath- ... Full text Link to item Cite

Novel Magnetic Resonance Imaging for Assessment of Bronchial Stenosis in Lung Transplant Recipients.

Journal Article Am J Transplant · July 2017 Bronchial stenosis in lung transplant recipients is a common disorder that adversely affects clinical outcomes. It is evaluated by spirometry, CT scanning, and bronchoscopy with significant limitations. We hypothesize that MRI using both ultrashort echo ti ... Full text Link to item Cite

Quantitative analysis of hyperpolarized 129 Xe gas transfer MRI.

Journal Article Med Phys · June 2017 PURPOSE: Hyperpolarized 129 Xe magnetic resonance imaging (MRI) using Dixon-based decomposition enables single-breath imaging of 129 Xe in the airspaces, interstitial barrier tissues, and red blood cells (RBCs). However, methods to quantitatively visualize ... Full text Link to item Cite

Establishing an accurate gas phase reference frequency to quantify 129 Xe chemical shifts in vivo.

Journal Article Magn Reson Med · April 2017 PURPOSE: 129 Xe interacts with biological media to exhibit chemical shifts exceeding 200 ppm that report on physiology and pathology. Extracting this functional information requires shifts to be measured precisely. Historically, shifts have been reported r ... Full text Link to item Cite

Three-dimensional echo-planar cine imaging of cerebral blood supply using arterial spin labeling.

Journal Article Magma (New York, N.Y.) · December 2016 ObjectiveEcho-planar imaging (EPI) with CYlindrical Center-out spatiaL Encoding (EPICYCLE) is introduced as a novel hybrid three-dimensional (3D) EPI technique. Its suitability for the tracking of a short bolus created by pseudo-continuous arteria ... Full text Cite

TH-EF-BRA-10: High Spatiotemporal Resolution Self-Sorted 4D MRI.

Journal Article Med Phys · June 2016 PURPOSE: To describe a novel method for self-sorted 4D-MRI and to characterize the output image quality as measured by signal-to-noise ratio (SNR), spatiotemporal resolution, and level of artifact. METHODS: A three-dimensional radial sampling function with ... Full text Link to item Cite

Single-breath clinical imaging of hyperpolarized (129)Xe in the airspaces, barrier, and red blood cells using an interleaved 3D radial 1-point Dixon acquisition.

Journal Article Magn Reson Med · April 2016 PURPOSE: We sought to develop and test a clinically feasible 1-point Dixon, three-dimensional (3D) radial acquisition strategy to create isotropic 3D MR images of (129)Xe in the airspaces, barrier, and red blood cells (RBCs) in a single breath. The approac ... Full text Link to item Cite

Differentiating Early Stage And Later Stage Ipf Using Hyperpolarized 129xe Ventilation Mri

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2016 Link to item Cite

Dose and pulse sequence considerations for hyperpolarized (129)Xe ventilation MRI.

Journal Article Magn Reson Imaging · September 2015 PURPOSE: The aim of this study was to evaluate the effect of hyperpolarized (129)Xe dose on image signal-to-noise ratio (SNR) and ventilation defect conspicuity on both multi-slice gradient echo and isotropic 3D-radially acquired ventilation MRI. MATERIALS ... Full text Link to item Cite

Optimizing 3D noncartesian gridding reconstruction for hyperpolarized 129Xe MRI-focus on preclinical applications

Journal Article Concepts in Magnetic Resonance Part A: Bridging Education and Research · July 1, 2015 The goal of this work is to characterize and optimize gridding reconstruction of 3D radial hyperpolarized (HP) 129Xe MRI. In support of this objective, we developed a flexible, open source reconstruction software package in MATLAB to optimally reconstruct ... Full text Cite

3D MRI of impaired hyperpolarized 129Xe uptake in a rat model of pulmonary fibrosis.

Journal Article NMR Biomed · December 2014 A variety of pulmonary pathologies, in particular interstitial lung diseases, are characterized by thickening of the pulmonary blood-gas barrier, and this thickening results in reduced gas exchange. Such diffusive impairment is challenging to quantify spat ... Full text Link to item Cite

Extending semiautomatic ventilation defect analysis for hyperpolarized (129)Xe ventilation MRI.

Journal Article Acad Radiol · December 2014 RATIONALE AND OBJECTIVES: Clinical deployment of hyperpolarized (129)Xe magnetic resonance imaging requires accurate quantification and visualization of the ventilation defect percentage (VDP). Here, we improve the robustness of our previous semiautomated ... Full text Link to item Cite

Hyperpolarized 129xe Mri To Quantify Regional Ventilation Differences In Older Versus Younger Asthmatics

Journal Article AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2014 Link to item Cite

Probing the regional distribution of pulmonary gas exchange through single-breath gas- and dissolved-phase 129Xe MR imaging.

Journal Article J Appl Physiol (1985) · September 2013 Although some central aspects of pulmonary function (ventilation and perfusion) are known to be heterogeneous, the distribution of diffusive gas exchange remains poorly characterized. A solution is offered by hyperpolarized 129Xe magnetic resonance (MR) im ... Full text Link to item Cite

Reproducibility Of Hyperpolarized 129xe Mri: Alveolar Capillary Gas-Transfer Spectroscopy And Imaging

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2013 Link to item Cite

Multiscale computational analysis of Xenopus laevis morphogenesis reveals key insights of systems-level behavior.

Journal Article BMC systems biology · October 2007 BackgroundTissue morphogenesis is a complex process whereby tissue structures self-assemble by the aggregate behaviors of independently acting cells responding to both intracellular and extracellular cues in their environment. During embryonic dev ... Full text Cite