Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • M.D., Texas A&M University, College of Medicine 1992
• Publications & Artistic Works
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  Selected Publications

  • Academic Articles

    • Knudsen, Cecilie, Jonas A. Jürgensen, Sofie Føns, Aleksander M. Haack, Rasmus U. W. Friis, Søren H. Dam, Sean P. Bush, Julian White, and Andreas H. Laustsen. “Snakebite Envenoming Diagnosis and Diagnostics.” Front Immunol 12 (2021): 661457. https://doi.org/10.3389/fimmu.2021.661457.
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    • Dart, Richard C., Sean P. Bush, Kennon Heard, Thomas C. Arnold, Mark Sutter, Danielle Campagne, Christopher P. Holstege, et al. “The Efficacy of Antivenin Latrodectus (Black Widow) Equine Immune F(ab')2 Versus Placebo in the Treatment of Latrodectism: A Randomized, Double-Blind, Placebo-Controlled, Clinical Trial.” Ann Emerg Med 74, no. 3 (September 2019): 439–49. https://doi.org/10.1016/j.annemergmed.2019.02.007.
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    • Kanaan, N. C., J. Ray, M. Stewart, M. Fuller, E. Martin Caravati, K. W. Russell, S. P. Bush, M. D. Cardwell, R. L. Norris, and S. A. Weinstein. “In Reply to Drs Boyer and Ruha.” Wilderness and Environmental Medicine 27, no. 2 (June 1, 2016): 342–44. https://doi.org/10.1016/j.wem.2015.12.012.
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    • Kanaan, Nicholas C., Jeremiah Ray, Matthew Stewart, Katie W. Russell, Matthew Fuller, Sean P. Bush, E Martin Caravati, Michael D. Cardwell, Robert L. Norris, and Scott A. Weinstein. “Wilderness Medical Society Practice Guidelines for the Treatment of Pitviper Envenomations in the United States and Canada.” Wilderness Environ Med 26, no. 4 (December 2015): 472–87. https://doi.org/10.1016/j.wem.2015.05.007.
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    • Parker-Cote, Jennifer L., Dorcas P. O’Rourke, Kori L. Brewer, Kvin Lertpiriyapong, Mohan Punja, Sean P. Bush, Susan N. Miller, and William J. Meggs. “Efficacy of Trypsin in Treating Coral Snake Envenomation in the Porcine Model.” J Med Toxicol 11, no. 4 (December 2015): 430–32. https://doi.org/10.1007/s13181-015-0468-x.
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    • Bush, Sean P., and J Veeran Davy. “Troponin elevation after black widow spider envenomation.” Cjem 17, no. 5 (September 2015): 571–75. https://doi.org/10.1017/cem.2015.82.
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    • Bush, Sean P., and Shannon B. Kinlaw. “Management of a Pediatric Snake Envenomation After Presentation With a Tight Tourniquet.” Wilderness Environ Med 26, no. 3 (September 2015): 355–58. https://doi.org/10.1016/j.wem.2015.01.005.
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    • Bush, Sean P., Anne-Michelle Ruha, Steven A. Seifert, Dawn R. Sollee, and Leslie V. Boyer. “In reply re: "comparison of F(ab')2 versus Fab antivenom for pit viper envenomation: a prospective, blinded, multicenter, randomized clinical trial".” Clin Toxicol (Phila) 53, no. 4 (May 2015): 414–15. https://doi.org/10.3109/15563650.2015.1016167.
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    • Bush, Sean P., and Maryjoy Rosalie Lepak. “Reply: severe anaphylactic reaction following crotalidae polyvalent immune fab (ovine) administration for copperhead snakebite.” Ann Pharmacother 49, no. 4 (April 2015): 497–98. https://doi.org/10.1177/1060028015571164.
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    • Bush, Sean P., Anne-Michelle Ruha, Steven A. Seifert, David L. Morgan, Brandon J. Lewis, Thomas C. Arnold, Richard F. Clark, et al. “Comparison of F(ab')2 versus Fab antivenom for pit viper envenomation: a prospective, blinded, multicenter, randomized clinical trial.” Clin Toxicol (Phila) 53, no. 1 (January 2015): 37–45. https://doi.org/10.3109/15563650.2014.974263.
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    • Lepak, Maryjoy R., Samantha H. Bochenek, and Sean P. Bush. “Severe adverse drug reaction following Crotalidae Polyvalent Immune Fab (Ovine) administration for copperhead snakebite.” Ann Pharmacother 49, no. 1 (January 2015): 145–49. https://doi.org/10.1177/1060028014555711.
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    • Cabaniss, Wyman W., Sean Bush, Dorcas P. O’Rourke, Paul F. Fletcher, Kori L. Brewer, Kvin Lertpiriyapong, Mohan Punja, Susan N. Miller, and William J. Meggs. “A randomized controlled trial of trypsin to treat brown recluse spider bites in Guinea pigs.” J Med Toxicol 10, no. 3 (September 2014): 266–68. https://doi.org/10.1007/s13181-014-0405-4.
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    • Bush, Sean P., Graham G. Mooy, and Tammy H. Phan. “Catastrophic acute ischemic stroke after Crotalidae polyvalent immune Fab (ovine)-treated rattlesnake envenomation.” Wilderness Environ Med 25, no. 2 (June 2014): 198–203. https://doi.org/10.1016/j.wem.2013.11.009.
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    • Bush, Sean, Rohn McCune, and Tammy Phan. “Priapism after western black widow spider (Latrodectus hesperus) envenomation.” Wilderness Environ Med 25, no. 1 (March 2014): 80–81. https://doi.org/10.1016/j.wem.2013.10.008.
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    • Bush, Sean P., Steven A. Seifert, Jennifer Oakes, Susan D. Smith, Tammy H. Phan, Sarah R. Pearl, and Ellen T. Reibling. “Continuous IV Crotalidae Polyvalent Immune Fab (Ovine) (FabAV) for selected North American rattlesnake bite patients.” Toxicon 69 (July 2013): 29–37. https://doi.org/10.1016/j.toxicon.2013.02.008.
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    • Dart, R. C., G. Bogdan, K. Heard, B. B. Bartelson, W. Garcia-Ubbelohde, S. Bush, T. Arnold, et al. “A randomized, double-blind, placebo-controlled trial of a highly purified equine F(ab)2 antibody black widow spider antivenom.” Annals of Emergency Medicine 61, no. 4 (January 1, 2013): 458–67. https://doi.org/10.1016/j.annemergmed.2012.10.008.
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    • Lavonas, Eric J., Anne-Michelle Ruha, William Banner, Vikhyat Bebarta, Jeffrey N. Bernstein, Sean P. Bush, William P. Kerns, et al. “Unified treatment algorithm for the management of crotaline snakebite in the United States: results of an evidence-informed consensus workshop.” Bmc Emerg Med 11 (February 3, 2011): 2. https://doi.org/10.1186/1471-227X-11-2.
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    • Janes, Donald N., Sean P. Bush, and Gita R. Kolluru. “Large snake size suggests increased snakebite severity in patients bitten by rattlesnakes in Southern california.” Wilderness Environ Med 21, no. 2 (June 2010): 120–26. https://doi.org/10.1016/j.wem.2010.01.010.
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    • Offerman, Steven R., J David Barry, William H. Richardson, Tri Tong, Dave Tanen, Sean P. Bush, and Richard F. Clark. “Subcutaneous Crotaline Fab antivenom for the treatment of rattlesnake envenomation in a porcine model.” Clin Toxicol (Phila) 47, no. 1 (January 2009): 61–68. https://doi.org/10.1080/15563650701750613.
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    • Jurado, Jennifer D., Eppie D. Rael, Carl S. Lieb, Ernesto Nakayasu, William K. Hayes, Sean P. Bush, and Jeremy A. Ross. “Complement inactivating proteins and intraspecies venom variation in Crotalus oreganus helleri.” Toxicon 49, no. 3 (March 1, 2007): 339–50. https://doi.org/10.1016/j.toxicon.2006.10.004.
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    • Vetter, Richard S., Geoffrey K. Isbister, Sean P. Bush, and Lisa J. Boutin. “Verified bites by yellow sac spiders (genus Cheiracanthium) in the United States and Australia: where is the necrosis?” Am J Trop Med Hyg 74, no. 6 (June 2006): 1043–48.
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    • Corbett, Stephen W., Brian Anderson, Brett Nelson, Sean Bush, William K. Hayes, and Mike D. Cardwell. “Most lay people can correctly identify indigenous venomous snakes.” Am J Emerg Med 23, no. 6 (October 2005): 759–62. https://doi.org/10.1016/j.ajem.2005.03.008.
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    • Matteucci, Michael J., Saralyn R. Williams, and Richard F. Clark. “Response to Latrodectus-associated compartment syndrome.” Ann Emerg Med 45, no. 6 (June 2005): 679–80. https://doi.org/10.1016/j.annemergmed.2004.12.033.
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    • Cohen, Jennifer, and Sean Bush. “Case report: compartment syndrome after a suspected black widow spider bite.” Ann Emerg Med 45, no. 4 (April 2005): 414–16. https://doi.org/10.1016/j.annemergmed.2004.06.018.
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    • Isbister, Geoffrey K., Julian White, Bart J. Currie, Sean P. Bush, Richard S. Vetter, and David A. Warrell. “Spider bites: addressing mythology and poor evidence.” Am J Trop Med Hyg 72, no. 4 (April 2005): 361–64.
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    • Bush, Sean P., Steven M. Green, Torrey A. Laack, William K. Hayes, Michael D. Cardwell, and David A. Tanen. “Pressure immobilization delays mortality and increases intracompartmental pressure after artificial intramuscular rattlesnake envenomation in a porcine model.” Ann Emerg Med 44, no. 6 (December 2004): 599–604. https://doi.org/10.1016/j.annemergmed.2004.06.007.
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    • French, Wendy J., William K. Hayes, Sean P. Bush, Michael D. Cardwell, Julia O. Bader, and Eppie D. Rael. “Mojave toxin in venom of Crotalus helleri (Southern Pacific Rattlesnake): molecular and geographic characterization.” Toxicon 44, no. 7 (December 1, 2004): 781–91. https://doi.org/10.1016/j.toxicon.2004.08.008.
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    • Vetter, Richard S., and Sean P. Bush. “Additional considerations in presumptive brown recluse spider bites and dapsone therapy.” Am J Emerg Med 22, no. 6 (October 2004): 494–95. https://doi.org/10.1016/j.ajem.2004.07.001.
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    • Bush, Sean P. “Snakebite suction devices don't remove venom: they just suck.” Ann Emerg Med 43, no. 2 (February 2004): 187–88. https://doi.org/10.1016/j.annemergmed.2003.10.031.
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    • Lavonas, Eric J., Charles J. Gerardo, Gerald O’Malley, Thomas C. Arnold, Sean P. Bush, William Banner, Mark Steffens, and William P. Kerns. “Initial experience with Crotalidae polyvalent immune Fab (ovine) antivenom in the treatment of copperhead snakebite.” Ann Emerg Med 43, no. 2 (February 2004): 200–206. https://doi.org/10.1016/j.annemergmed.2003.08.009.
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    • Behm, Martin O., and Gregory L. Kearns. “Crotaline Fab antivenom for treatment of children with rattlesnake envenomation.” Pediatrics 112, no. 6 Pt 1 (December 2003): 1458–59. https://doi.org/10.1542/peds.112.6.1458.
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    • Bush, Sean P. “Why no antivenom?” Ann Emerg Med 42, no. 3 (September 2003): 431–32. https://doi.org/10.1016/s0196-0644(03)00520-1.
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    • Bush, Sean P., Steven M. Green, James A. Moynihan, William K. Hayes, and Michael D. Cardwell. “Crotalidae polyvalent immune Fab (ovine) antivenom is efficacious for envenomations by Southern Pacific rattlesnakes (Crotalus helleri).” Ann Emerg Med 40, no. 6 (December 2002): 619–24. https://doi.org/10.1067/mem.2002.129939.
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    • Offerman, Steven R., Sean P. Bush, James A. Moynihan, and Richard F. Clark. “Crotaline Fab antivenom for the treatment of children with rattlesnake envenomation.” Pediatrics 110, no. 5 (November 2002): 968–71. https://doi.org/10.1542/peds.110.5.968.
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    • Vetter, Richard S., and Sean P. Bush. “Reports of presumptive brown recluse spider bites reinforce improbable diagnosis in regions of North America where the spider is not endemic.” Clin Infect Dis 35, no. 4 (August 15, 2002): 442–45. https://doi.org/10.1086/341244.
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    • Vetter, Richard S., and Sean P. Bush. “The diagnosis of brown recluse spider bite is overused for dermonecrotic wounds of uncertain etiology.” Ann Emerg Med 39, no. 5 (May 2002): 544–46.
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    • Vetter, Richard S., and Sean P. Bush. “Chemical burn misdiagnosed as brown recluse spider bite.” Am J Emerg Med 20, no. 1 (January 2002): 68–69. https://doi.org/10.1053/ajem.2002.30001.
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    • Bush, S. P., and D. L. Hardy. “Immediate removal of extractor is recommended.” Ann Emerg Med 38, no. 5 (November 2001): 607–8. https://doi.org/10.1067/mem.2001.119280.
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    • Johnson, J. C. “A potential hole in the safety net.” Ann Emerg Med 38, no. 5 (November 2001): 604–5. https://doi.org/10.1067/mem.2001.119275.
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    • Bush, S. P., B. O. King, R. L. Norris, and S. A. Stockwell. “Centipede envenomation.” Wilderness Environ Med 12, no. 2 (2001): 93–99. https://doi.org/10.1580/1080-6032(2001)012[0093:ce]2.0.co;2.
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    • Ho, J., and S. P. Bush. “Clinical pearls: painful tongue swelling.” Acad Emerg Med 7, no. 8 (August 2000): 918–43. https://doi.org/10.1111/j.1553-2712.2000.tb02071.x.
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    • Bush, S. P., V. H. Wu, and S. W. Corbett. “Rattlesnake venom-induced thrombocytopenia response to Antivenin (Crotalidae) Polyvalent: a case series.” Acad Emerg Med 7, no. 2 (February 2000): 181–85. https://doi.org/10.1111/j.1553-2712.2000.tb00524.x.
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    • Bush, S. P., K. G. Hegewald, S. M. Green, M. D. Cardwell, and W. K. Hayes. “Effects of a negative pressure venom extraction device (Extractor) on local tissue injury after artificial rattlesnake envenomation in a porcine model.” Wilderness Environ Med 11, no. 3 (2000): 180–88. https://doi.org/10.1580/1080-6032(2000)011[0180:eoanpv]2.3.co;2.
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    • Bush, S. P., P. Giem, and R. S. Vetter. “Green lynx spider (Peucetia viridans) envenomation.” Am J Emerg Med 18, no. 1 (January 2000): 64–66. https://doi.org/10.1016/s0735-6757(00)90052-4.
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    • Bush, S. P., and E. Siedenberg. “Erratum: Neurotoxicity associated with suspected Southern Pacific rattlesnake (Cotalus viridis helleri) envenomation (Wilderness and Environmental Medicine 10:4 (247)).” Wilderness and Environmental Medicine 11, no. 3 (January 1, 2000): 226. https://doi.org/10.1580/1080-6032(2000)011[0226:e]2.3.co;2.
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    • Merin, D. S., and S. P. Bush. “Severe hand injury following a green iguana bite.” Wilderness Environ Med 11, no. 3 (2000): 225–26. https://doi.org/10.1580/1080-6032(2000)011[0225:shifag]2.3.co;2.
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    • Bush, S. P. “Black widow spider envenomation mimicking cholecystitis.” Am J Emerg Med 17, no. 3 (May 1999): 315. https://doi.org/10.1016/s0735-6757(99)90137-7.
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    • Bush, S. P. “Envenomation by the scorpion (Centruroides limbatus) outside its natural range and recognition of medically important scorpions.” Wilderness Environ Med 10, no. 3 (1999): 161–64. https://doi.org/10.1580/1080-6032(1999)010[0161:ebtslo]2.3.co;2.
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    • Bush, S. P., and E. Siedenburg. “Neurotoxicity associated with suspected southern Pacific rattlesnake (Crotalus viridis helleri) envenomation.” Wilderness Environ Med 10, no. 4 (1999): 247–49. https://doi.org/10.1580/1080-6032(1999)010[0247:nawssp]2.3.co;2.
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    • Bush, S. P., and M. D. Cardwell. “Mojave rattlesnake (Crotalus scutulatus scutulatus) identification.” Wilderness Environ Med 10, no. 1 (1999): 6–9. https://doi.org/10.1580/1080-6032(1999)010[0006:mrssi]2.3.co;2.
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    • Hardy, D. L., and S. P. Bush. “Pressure/immobilization as first aid for venomous snakebite in the United States.” Herpetological Review 29, no. 4 (December 1, 1998): 204–8.
    • Bush, S. P. “Anesthesia for fish envenomation.” Ann Emerg Med 29, no. 5 (May 1997): 692–93. https://doi.org/10.1016/s0196-0644(97)70261-0.
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    • Farstad, D., T. Thomas, T. Chow, S. Bush, and P. Stiegler. “Mojave rattlesnake envenomation in southern California: a review of suspected cases.” Wilderness Environ Med 8, no. 2 (May 1997): 89–93. https://doi.org/10.1580/1080-6032(1997)008[0089:MREISC]2.3.CO;2.
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    • Bush, S. P., and J. Naftel. “Injection of a whole black widow spider.” Ann Emerg Med 27, no. 4 (April 1996): 532–33. https://doi.org/10.1016/s0196-0644(96)70256-1.
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    • Bush, S. P., and P. W. Jansen. “Severe rattlesnake envenomation with anaphylaxis and rhabdomyolysis.” Ann Emerg Med 25, no. 6 (June 1995): 845–48. https://doi.org/10.1016/s0196-0644(95)70218-0.
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  • Book Sections

    • Bush, S. “Snakebites: Rattlesnake bites.” In Observation Medicine: Principles and Protocols, 556–59, 2017. https://doi.org/10.1017/9781139136365.091.
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    • Bush, S. P. “Bites and Stings.” In Pediatric Critical Care, 1463–71, 2011. https://doi.org/10.1016/B978-0-323-07307-3.10107-7.
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    • Bush, S. P. “Bites and Stings.” In Pediatric Critical Care: Expert Consult Premium Edition, 1463–71, 2011. https://doi.org/10.1016/B978-0-323-07307-3.10107-7.
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    • Bush, S. P., and J. A. Moynihan. “Snake and Spider Envenomations.” In Pediatric Emergency Medicine, 1002–10, 2008. https://doi.org/10.1016/B978-141600087-7.50144-6.
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    • Bush, S. P. “Bites and Stings.” In Pediatric Critical Care, 1532–43, 2006. https://doi.org/10.1016/B978-032301808-1.50103-6.
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  • Conference Papers

    • Audi, J., S. A. Seifert, J. F. Gennaro, J. W. Skimming, L. H. S. Van Mierop, C. S. Kitchens, M. D. Cardwell, et al. “Snakebites in the new millennium. Proceedings of a state-of-the-art symposium. October 21-13, 2005. Omaha, Nebraska, USA.” In J Med Toxicol, 2:29–45, 2006. https://doi.org/10.1007/BF03161012.
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