Scholars@Duke
Sean Paul Montgomery

Sean Paul Montgomery

Associate Professor of Surgery
Trauma, Acute, and Critical Care Surgery

Selected Publications

Velocity changes in femoral vessel ultrasound with Doppler in Porcine hemorrhagic shock.

Journal Article Heliyon · January 15, 2024 OBJECTIVE: Physician-directed point-of-care ultrasound (PoCUS) is routinely used to identify the etiology of shock and guide therapy in the ICU. We performed a preclinical study to determine what changes are manifested in the femoral vessels during hemorrh ... Full text Link to item Cite

Optic Nerve Sheath Point of Care Ultrasound: Image Acquisition.

Journal Article J Vis Exp · August 18, 2023 The goal of this protocol is to develop a standardized method for acquiring images of the optic nerve sheath and measuring the optic nerve sheath diameter (ONSD). Diagnostic ultrasound of the ONSD to detect intracranial hypertension has traditionally faced ... Full text Link to item Cite

Detection of pneumothorax on ultrasound using artificial intelligence.

Journal Article J Trauma Acute Care Surg · March 1, 2023 BACKGROUND: Ultrasound (US) for the detection of pneumothorax shows excellent sensitivity in the hands of skilled providers. Artificial intelligence may facilitate the movement of US for pneumothorax into the prehospital setting. The large amount of traini ... Full text Link to item Cite

A Portable Negative Pressure Isolation System as a Solution to Minimize Exposure of Health Care Providers to Infectious Pathogens.

Journal Article Am Surg · August 2022 The COVID-19 pandemic has resulted in the exposure of many surgeons and healthcare providers (HCPs) to disease given high patient loads and limited availability of negative pressure rooms. For these reasons we pursued the development of a portable patient ... Full text Link to item Cite

War and pandemics: Catalysts for medical advancement.

Journal Article J Trauma Acute Care Surg · October 2020 Full text Link to item Cite

"I'm Leaving": Factors That Impact Against Medical Advice Disposition Post-Trauma.

Journal Article J Emerg Med · April 2020 BACKGROUND: Discharge against medical advice (AMA) is an important, yet understudied, aspect of health care-particularly in trauma populations. AMA discharges result in increased mortality, increased readmission rates, and higher health care costs. OBJECTI ... Full text Link to item Cite

Automatic Optic Nerve Sheath Measurement in Point-of-Care Ultrasound

Conference Lecture Notes in Computer Science Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics · January 1, 2020 Intracranial hypertension associated with traumatic brain injury is a life-threatening condition which requires immediate diagnosis and treatment. The measurement of optic nerve sheath diameter (ONSD), using ultrasonography, has been shown to be a promisin ... Full text Cite

Helicopter medical evacuation in the Korean War: Did it matter?

Journal Article J Trauma Acute Care Surg · July 2019 BACKGROUND: Because of M*A*S*H and other popular portrayals, helicopter evacuation of casualties has been closely linked to the Korean War. We sought to investigate their role in military medicine during this conflict. METHODS: This study incorporated a th ... Full text Link to item Cite

Automatic Estimation of the Optic Nerve Sheath Diameter from Ultrasound Images.

Conference Imaging for patient-customized simulations and systems for point-of-care ultrasound : International Workshops, BIVPCS 2017 and POCUS 2017, held in conjunction with MICCAI 2017, Quebec City, QC, Canada, September 14, 2017, Proceedings. B... · September 2017 We present an algorithm to automatically estimate the diameter of the optic nerve sheath from ocular ultrasound images. The optic nerve sheath diameter provides a proxy for measuring intracranial pressure, a life threating condition frequently associated w ... Full text Cite

Standardized, Interdepartmental, Simulation-Based Central Line Insertion Course Closes an Educational Gap and Improves Intern Comfort with the Procedure (The American Surgeon, 2017)

Journal Article American Surgeon · September 1, 2017 The article entitled “A Standardized, Interdepartmental, Simulation-Based Central Line Insertion Course Closes an Educational Gap and Improves Intern Comfort with the Procedure”, printed in the June, 2017 issue of The American Surgeon listed one of the aut ... Full text Cite

A comparison of a homemade central line simulator to commercial models.

Journal Article J Surg Res · June 15, 2017 BACKGROUND: Simulation is quickly becoming vital to resident education, but commercially available central line models are costly and little information exists to evaluate their realism. This study compared an inexpensive homemade simulator to three commer ... Full text Link to item Cite

Standardized, Interdepartmental, Simulation-Based Central Line Insertion Course Closes an Educational Gap and Improves Intern Comfort with the Procedure.

Conference Am Surg · June 1, 2017 Central line placement is a common procedure, routinely performed by junior residents in medical and surgical departments. Before this project, no standardized instructional course on the insertion of central lines existed at our institution, and few inter ... Link to item Cite

Development and preliminary assessment of a critical care ultrasound course in an adult pulmonary and critical care fellowship program.

Journal Article Ann Am Thorac Soc · June 2014 BACKGROUND: The focused ultrasound examination has become increasingly recognized as a safe and valuable diagnostic tool for the bedside assessment of the critically ill patient. We implemented a dedicated on-site critical care ultrasonography curriculum w ... Full text Link to item Cite

The impact of country and culture on end-of-life care for injured patients: results from an international survey.

Journal Article J Trauma · December 2010 BACKGROUND: Up to 20% of all trauma patients admitted to an intensive care unit die from their injuries. End-of-life decision making is a variable process that involves prognosis, predicted functional outcomes, personal beliefs, institutional resources, so ... Full text Link to item Cite

Candida guilliermondii fungemia in a critically ill trauma patient

Journal Article Journal of Pharmacy Technology · January 1, 2010 Objective: To report a case of fungemia caused by Candida guilliermondii in a non-neutropenic 17-year-old critically ill trauma patient. Case Summary: Few case reports and small surveys have reported invasive infection caused by C. guilliermondii, most of ... Full text Cite

Airway management for victims of penetrating trauma: analysis of 50,000 cases.

Journal Article Am J Surg · December 2009 BACKGROUND: Current recommendations for victims of penetrating trauma include prompt transportation to a trauma center. It remains unclear whether field intubation allows for improvements in mortality rate. METHODS: A retrospective review of the National T ... Full text Link to item Cite

The evaluation of casualties from Operation Iraqi Freedom on return to the continental United States from March to June 2003.

Journal Article J Am Coll Surg · July 2005 BACKGROUND: Most seriously wounded US Army casualties from the Iraqi theater of operations come through Walter Reed Army Medical Center on their return to the United States. General surgery and orthopaedic surgery services have developed a multidisciplinar ... Full text Link to item Cite

Studies investigating pretransplant donor-specific blood transfusion, rapamycin, and the CD154-specific antibody IDEC-131 in a nonhuman primate model of skin allotransplantation.

Journal Article J Immunol · March 1, 2003 Anti-CD154 variably prolongs allograft survival in nonhuman primates. Rodent studies suggest that adding pretransplant donor-specific transfusion (DST) and/or rapamycin to anti-CD154 improves survival. The CD154-specific Ab IDEC-131 was tested alone and in ... Full text Link to item Cite

Combination induction therapy with monoclonal antibodies specific for CD80, CD86, and CD154 in nonhuman primate renal transplantation.

Journal Article Transplantation · November 27, 2002 BACKGROUND: Antibodies and fusion proteins specific for CD80, CD86, and CD154 have shown promise as agents capable of inducing donor-specific tolerance in rodents. These agents have also been shown to be synergistic with one another in many settings of cou ... Full text Link to item Cite

Humanized anti-CD154 antibody therapy for the treatment of allograft rejection in nonhuman primates.

Journal Article Transplantation · October 15, 2002 The anti-CD154 antibody hu5C8 prevents acute allograft rejection and prolongs allograft survival after withdrawal of therapy in nonhuman primates. This study describes the use of hu5C8 as a rescue agent for rejection developing after the withdrawal of hu5C ... Full text Link to item Cite

Pancreatic islet transplantation using the nonhuman primate (rhesus) model predicts that the portal vein is superior to the celiac artery as the islet infusion site.

Journal Article Diabetes · July 2002 We've established a nonhuman primate islet allotransplant model to address questions such as whether transplanting islets into the gut's arterial system would more safely and as effectively support long-term islet allograft survival compared with the tradi ... Full text Link to item Cite

Efficacy and toxicity of a protocol using sirolimus, tacrolimus and daclizumab in a nonhuman primate renal allotransplant model.

Journal Article Am J Transplant · April 2002 A regimen combining sirolimus, tacrolimus, and daclizumab has recently been shown to provide adequate immunosuppression for allogeneic islet transplantation in humans, but remains unproven for primarily vascularized allografts. We evaluated this regimen fo ... Full text Link to item Cite

Treatment with the humanized CD154-specific monoclonal antibody, hu5C8, prevents acute rejection of primary skin allografts in nonhuman primates.

Journal Article Transplantation · November 15, 2001 BACKGROUND: Allogeneic skin transplantation remains a rigorous test of any immune intervention designed to prevent allograft rejection. To date, no single, clinically available immunosuppressant has been reported to induce long-term primary skin allograft ... Full text Link to item Cite

Preclinical evaluation of tolerance induction protocols and islet transplantation in non-human primates.

Journal Article Immunol Rev · October 2001 Non-human primate studies of tolerance induction strategies in solid organ transplantation represent a critical bridge between studies in rodents and humans. Our work demonstrates that strategies involving the blockade of co-stimulatory molecules, especial ... Full text Link to item Cite

Intranasal immunization is superior to vaginal, gastric, or rectal immunization for the induction of systemic and mucosal anti-HIV antibody responses.

Journal Article AIDS Res Hum Retroviruses · July 20, 1997 Vaginal anti-HIV antibody responses may be beneficial, and possibly required, for vaccine-induced protection against HIV infection acquired through receptive vaginal intercourse. We have previously determined that intranasal immunization with a hybrid HIV ... Full text Link to item Cite