Shad Benjamin Smith
Associate Professor of Anesthesiology
Dr. Shad Smith is an assistant professor in the Department of Anesthesiology and holds a faculty position in the Center for Translational Pain Medicine (CTPM). Dr. Smith also has an adjunct appointment at the University of North Carolina at Chapel Hill, as part of the Center for Pain Research and Innovation (CPRI). He earned his bachelor’s degree in psychology with minors in chemistry and zoology from Brigham Young University, before moving on to graduate school.
In 2006, he graduated with a doctorate in psychology with an emphasis in behavioral neuroscience. Following his time at McGill, Dr. Smith accepted a post-doctoral fellowship in the CPRI at the UNC School of Dentistry. He received a Ruth L. Kirschstein National Research Service Award in 2008 to study the role of alpha adrenergic mechanisms in chronic orofacial pain. He joined the faculty at UNC as a research assistant professor in 2011. Dr. Smith has also served since 2007 as a research consultant, and since 2010 as the Director of Bioinformatics, for Algynomics, Inc., a Chapel Hill-based biotech firm spun off from research activities within the UNC School of Dentistry.
Dr. Smith joined the faculty at Duke University in 2016, where he continues his work with genetics of pain disorders. The primary focus of his research career has been the search for genetic variation that contributes to greater pain sensitivity and increased risk for chronic pain disease. He has worked for over a decade with genomic techniques, including both quantitative trait locus (QTL) mapping in the mouse and genetic association in human pain cohorts, investigating a number of pain-related diseases and phenotypes. Dr. Smith has published over 40 journal articles and book chapters, and presented his work at several international meetings. His work with projects such as the OPPERA (Orofacial Pain: Prospective Evaluation and Risk Assessment) study has resulted in a number of novel genes being recognized as genetic risk factors for pain.
Current Appointments & Affiliations
- Associate Professor of Anesthesiology, Anesthesiology, Clinical Science Departments 2021
Contact Information
- Background
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Education, Training, & Certifications
- Ph.D., McGill University (Canada) 2007
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Previous Appointments & Affiliations
- Assistant Professor in Anesthesiology, Anesthesiology, Clinical Science Departments 2015 - 2021
- Recognition
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Awards & Honors
- Biomedical Researcher Development Scholarship (BRDS). The University of North Carolina at Chapel Hill School of Dentistry . 2015
- Max Stern Recruitment Fellowship . McGill University . 2012
- Ruth L. Kirchstein National Research Service Award . National Institutes of Health . 2011
- CIHR Strategic Training Fellowship in Pain: Molecules to Community . Canadian Institutes of Health Research . 2006
- McGill Graduate Studies Fellowship. McGill University. 2004
- Expertise
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Subject Headings
- Research
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Selected Grants
- Sexually dimorphic pain signaling mechanisms awarded by National Institutes of Health 2022 - 2026
- Neural Architecture of the Murine and Human Temporomandibular Joint awarded by National Institutes of Health 2022 - 2025
- Identification of TMD pain drivers through patient stratification and multi-omic analyses awarded by National Institutes of Health 2022 - 2023
- DNA Methylation and Mediation of Risk Factors for Chronic Facial Pain awarded by McGill University 2019 - 2023
- Role of Preoperative Baroreflex Sensitivity on Persistent Postoperative Pain and Opioid Consumption after Thoracic Surgery awarded by National Institutes of Health 2019 - 2022
- Analgesic effects of perioperative propranolol administration for spine surgery awarded by Foundation for Anesthesia Education and Research 2020
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External Relationships
- Great River Learning
- McGill University; Canadian Institutes of Health Research
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Wilson, Jenna M., Carin A. Colebaugh, K Mikayla Flowers, Demario Overstreet, Robert R. Edwards, William Maixner, Shad B. Smith, and Kristin L. Schreiber. “Applying the Rapid OPPERA Algorithm to Predict Persistent Pain Outcomes Among a Cohort of Women Undergoing Breast Cancer Surgery.” J Pain 23, no. 12 (December 2022): 2003–12. https://doi.org/10.1016/j.jpain.2022.07.012.Full Text Link to Item
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Brownstein, Naomi C., Jianwen Cai, Shad Smith, Luda Diatchenko, Gary D. Slade, and Eric Bair. “Modeling Secondary Phenotypes Conditional on Genotypes in Case–Control Studies.” Stats 5, no. 1 (February 22, 2022): 203–14. https://doi.org/10.3390/stats5010014.Full Text
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Gaynor, Sheila M., Andrey Bortsov, Eric Bair, Roger B. Fillingim, Joel D. Greenspan, Richard Ohrbach, Luda Diatchenko, et al. “Phenotypic profile clustering pragmatically identifies diagnostically and mechanistically informative subgroups of chronic pain patients.” Pain 162, no. 5 (May 1, 2021): 1528–38. https://doi.org/10.1097/j.pain.0000000000002153.Full Text Link to Item
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Graff, Mariaelisa, Anne E. Justice, Kristin L. Young, Eirini Marouli, Xinruo Zhang, Rebecca S. Fine, Elise Lim, et al. “Discovery and fine-mapping of height loci via high-density imputation of GWASs in individuals of African ancestry.” Am J Hum Genet 108, no. 4 (April 1, 2021): 564–82. https://doi.org/10.1016/j.ajhg.2021.02.011.Full Text Link to Item
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Khoury, Samar, Qiao-Ping Wang, Marc Parisien, Pavel Gris, Andrey V. Bortsov, Sarah D. Linnstaedt, Samuel A. McLean, et al. “Multi-ethnic GWAS and meta-analysis of sleep quality identify MPP6 as a novel gene that functions in sleep center neurons.” Sleep 44, no. 3 (March 12, 2021). https://doi.org/10.1093/sleep/zsaa211.Full Text Open Access Copy Link to Item
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Tilburg, Miranda A. L. van, Marc Parisien, Richard G. Boles, Gillian L. Drury, Julian Smith-Voudouris, Vivek Verma, Samar Khoury, et al. “A genetic polymorphism that is associated with mitochondrial energy metabolism increases risk of fibromyalgia.” Pain 161, no. 12 (December 2020): 2860–71. https://doi.org/10.1097/j.pain.0000000000001996.Full Text Open Access Copy Link to Item
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Upadhyay, Udita, Gerald Z. Zhuang, Luda Diatchenko, Marc Parisien, Yuan Kang, Konstantinos D. Sarantopoulos, Eden R. Martin, Shad B. Smith, William Maixner, and Roy C. Levitt. “Reversion mutation of cDNA CA8-204 minigene construct produces a truncated functional peptide that regulates calcium release in vitro and produces profound analgesia in vivo.” Mamm Genome 31, no. 9–12 (December 2020): 287–94. https://doi.org/10.1007/s00335-020-09848-y.Full Text Link to Item
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Khoury, Samar, Marjo H. Piltonen, Anh-Tien Ton, Tiffany Cole, Alexander Samoshkin, Shad B. Smith, Inna Belfer, et al. “A functional substitution in the L-aromatic amino acid decarboxylase enzyme worsens somatic symptoms via a serotonergic pathway.” Ann Neurol 86, no. 2 (August 2019): 168–80. https://doi.org/10.1002/ana.25521.Full Text Link to Item
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Upadhyay, Udita, Gerald Z. Zhuang, Luda Diatchenko, Marc Parisien, Yuan Kang, Konstantinos D. Sarantopoulos, Eden R. Martin, Shad B. Smith, William Maixner, and Roy C. Levitt. “Profound analgesia is associated with a truncated peptide resulting from tissue specific alternative splicing of DRG CA8-204 regulated by an exon-level cis-eQTL.” Plos Genet 15, no. 6 (June 2019): e1008226. https://doi.org/10.1371/journal.pgen.1008226.Full Text Link to Item
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Smith, Shad B., Marc Parisien, Eric Bair, Inna Belfer, Anne-Julie Chabot-Doré, Pavel Gris, Samar Khoury, et al. “Genome-wide association reveals contribution of MRAS to painful temporomandibular disorder in males.” Pain 160, no. 3 (March 2019): 579–91. https://doi.org/10.1097/j.pain.0000000000001438.Full Text Open Access Copy Link to Item
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Karasik, David, M Carola Zillikens, Yi-Hsiang Hsu, Ali Aghdassi, Kristina Akesson, Najaf Amin, Inês Barroso, et al. “Disentangling the genetics of lean mass.” Am J Clin Nutr 109, no. 2 (February 1, 2019): 276–87. https://doi.org/10.1093/ajcn/nqy272.Full Text Link to Item
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Zhuang, Gerald Z., Udita Upadhyay, Xiaoying Tong, Yuan Kang, Diana M. Erasso, Eugene S. Fu, Konstantinos D. Sarantopoulos, et al. “Human carbonic anhydrase-8 AAV8 gene therapy inhibits nerve growth factor signaling producing prolonged analgesia and anti-hyperalgesia in mice.” Gene Ther 25, no. 4 (July 2018): 297–311. https://doi.org/10.1038/s41434-018-0018-7.Full Text Link to Item
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Sigurdsson, Martin I., Nathan H. Waldron, Andrey V. Bortsov, Shad B. Smith, and William Maixner. “Genomics of Cardiovascular Measures of Autonomic Tone.” J Cardiovasc Pharmacol 71, no. 3 (March 2018): 180–91. https://doi.org/10.1097/FJC.0000000000000559.Full Text Link to Item
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Fu, Eugene S., Diana M. Erasso, Gerald Z. Zhuang, Udita Upadhyay, Mehtap Ozdemir, Timothy Wiltshire, Konstantinos D. Sarantopoulos, et al. “Impact of human CA8 on thermal antinociception in relation to morphine equivalence in mice.” Neuroreport 28, no. 18 (December 13, 2017): 1215–20. https://doi.org/10.1097/WNR.0000000000000872.Full Text Link to Item
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Zillikens, M Carola, Serkalem Demissie, Yi-Hsiang Hsu, Laura M. Yerges-Armstrong, Wen-Chi Chou, Lisette Stolk, Gregory Livshits, et al. “Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.” Nat Commun 8, no. 1 (November 7, 2017): 1414. https://doi.org/10.1038/s41467-017-01008-2.Full Text Open Access Copy Link to Item
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Levitt, Roy C., Gerald Y. Zhuang, Yuan Kang, Diana M. Erasso, Udita Upadhyay, Mehtap Ozdemir, Eugene S. Fu, et al. “Car8 dorsal root ganglion expression and genetic regulation of analgesic responses are associated with a cis-eQTL in mice.” Mamm Genome 28, no. 9–10 (October 2017): 407–15. https://doi.org/10.1007/s00335-017-9694-7.Full Text Link to Item
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Martin, Loren J., Shad B. Smith, Arkady Khoutorsky, Claire A. Magnussen, Alexander Samoshkin, Robert E. Sorge, Chulmin Cho, et al. “Epiregulin and EGFR interactions are involved in pain processing.” J Clin Invest 127, no. 9 (September 1, 2017): 3353–66. https://doi.org/10.1172/JCI87406.Full Text Link to Item
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Zillikens, M Carola, Serkalem Demissie, Yi-Hsiang Hsu, Laura M. Yerges-Armstrong, Wen-Chi Chou, Lisette Stolk, Gregory Livshits, et al. “Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.” Nat Commun 8, no. 1 (July 19, 2017): 80. https://doi.org/10.1038/s41467-017-00031-7.Full Text Link to Item
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Parisien, Marc, Samar Khoury, Anne-Julie Chabot-Doré, Susana G. Sotocinal, Gary D. Slade, Shad B. Smith, Roger B. Fillingim, et al. “Effect of Human Genetic Variability on Gene Expression in Dorsal Root Ganglia and Association with Pain Phenotypes.” Cell Rep 19, no. 9 (May 30, 2017): 1940–52. https://doi.org/10.1016/j.celrep.2017.05.018.Full Text Link to Item
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Sanders, A. E., D. Jain, T. Sofer, K. F. Kerr, C. C. Laurie, J. R. Shaffer, M. L. Marazita, et al. “GWAS Identifies New Loci for Painful Temporomandibular Disorder: Hispanic Community Health Study/Study of Latinos.” J Dent Res 96, no. 3 (March 2017): 277–84. https://doi.org/10.1177/0022034516686562.Full Text Open Access Copy Link to Item
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Levitt, Alexandra E., Anat Galor, Aneesa R. Chowdhury, Elizabeth R. Felix, Constantinos D. Sarantopoulos, Gerald Y. Zhuang, Dennis Patin, et al. “Evidence that Dry Eye Represents a Chronic Overlapping Pain Condition.” Mol Pain 13 (2017): 1744806917729306. https://doi.org/10.1177/1744806917729306.Full Text Link to Item
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Maixner, William, Roger B. Fillingim, David A. Williams, Shad B. Smith, and Gary D. Slade. “Overlapping Chronic Pain Conditions: Implications for Diagnosis and Classification.” J Pain 17, no. 9 Suppl (September 2016): T93–107. https://doi.org/10.1016/j.jpain.2016.06.002.Full Text Link to Item
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Slade, G. D., R. Ohrbach, J. D. Greenspan, R. B. Fillingim, E. Bair, A. E. Sanders, R. Dubner, et al. “Painful Temporomandibular Disorder: Decade of Discovery from OPPERA Studies.” J Dent Res 95, no. 10 (September 2016): 1084–92. https://doi.org/10.1177/0022034516653743.Full Text Link to Item
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Bair, Eric, Sheila Gaynor, Gary D. Slade, Richard Ohrbach, Roger B. Fillingim, Joel D. Greenspan, Ronald Dubner, Shad B. Smith, Luda Diatchenko, and William Maixner. “Identification of clusters of individuals relevant to temporomandibular disorders and other chronic pain conditions: the OPPERA study.” Pain 157, no. 6 (June 2016): 1266–78. https://doi.org/10.1097/j.pain.0000000000000518.Full Text Link to Item
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Meloto, Carolina B., Andrey V. Bortsov, Eric Bair, Erika Helgeson, Cara Ostrom, Shad B. Smith, Ronald Dubner, et al. “Modification of COMT-dependent pain sensitivity by psychological stress and sex.” Pain 157, no. 4 (April 2016): 858–67. https://doi.org/10.1097/j.pain.0000000000000449.Full Text Link to Item
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Ciszek, Brittney P., Asma A. Khan, Hong Dang, Gary D. Slade, Shad Smith, Eric Bair, William Maixner, Denniz Zolnoun, and Andrea G. Nackley. “MicroRNA expression profiles differentiate chronic pain condition subtypes.” Transl Res 166, no. 6 (December 2015): 706-720.e11. https://doi.org/10.1016/j.trsl.2015.06.008.Full Text Link to Item
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Hsu, Yi-Hsiang, Youfang Liu, Marian T. Hannan, William Maixner, Shad B. Smith, Luda Diatchenko, Yvonne M. Golightly, et al. “Genome-wide association meta-analyses to identify common genetic variants associated with hallux valgus in Caucasian and African Americans.” J Med Genet 52, no. 11 (November 2015): 762–69. https://doi.org/10.1136/jmedgenet-2015-103142.Full Text Link to Item
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Meloto, Carolina B., Samantha K. Segall, Shad Smith, Marc Parisien, Svetlana A. Shabalina, Célia M. Rizzatti-Barbosa, Josée Gauthier, et al. “COMT gene locus: new functional variants.” Pain 156, no. 10 (October 2015): 2072–83. https://doi.org/10.1097/j.pain.0000000000000273.Full Text Link to Item
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Slade, G. D., A. E. Sanders, R. Ohrbach, E. Bair, W. Maixner, J. D. Greenspan, R. B. Fillingim, S. Smith, and L. Diatchenko. “COMT Diplotype Amplifies Effect of Stress on Risk of Temporomandibular Pain.” J Dent Res 94, no. 9 (September 2015): 1187–95. https://doi.org/10.1177/0022034515595043.Full Text Link to Item
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Wieskopf, Jeffrey S., Jayanti Mathur, Walrati Limapichat, Michael R. Post, Mona Al-Qazzaz, Robert E. Sorge, Loren J. Martin, et al. “The nicotinic α6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors.” Sci Transl Med 7, no. 287 (May 13, 2015): 287ra72. https://doi.org/10.1126/scitranslmed.3009986.Full Text Link to Item
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Zhuang, Gerald Z., Benjamin Keeler, Jeff Grant, Laura Bianchi, Eugene S. Fu, Yan Ping Zhang, Diana M. Erasso, et al. “Carbonic anhydrase-8 regulates inflammatory pain by inhibiting the ITPR1-cytosolic free calcium pathway.” Plos One 10, no. 3 (2015): e0118273. https://doi.org/10.1371/journal.pone.0118273.Full Text Link to Item
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Smith, Shad B., Ilkka Reenilä, Pekka T. Männistö, Gary D. Slade, William Maixner, Luda Diatchenko, and Andrea G. Nackley. “Epistasis between polymorphisms in COMT, ESR1, and GCH1 influences COMT enzyme activity and pain.” Pain 155, no. 11 (November 2014): 2390–99. https://doi.org/10.1016/j.pain.2014.09.009.Full Text Link to Item
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Liu, Youfang, Michelle Yau, Laura Yerges-Armstrong, Braxton Mitchell, Rebecca D. Jackson, Marc C. Hochberg, Shad Smith, William Maixner, Luda Diatchenko, and Joanne M. Jordan. “Genome-Wide Association Study for Severe Radiographic Knee Osteoarthritis.” Arthritis & Rheumatology 66 (October 1, 2014): S435–36.Link to Item
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Bair, Eric, Naomi C. Brownstein, Richard Ohrbach, Joel D. Greenspan, Ronald Dubner, Roger B. Fillingim, William Maixner, et al. “Study protocol, sample characteristics, and loss to follow-up: the OPPERA prospective cohort study.” J Pain 14, no. 12 Suppl (December 2013): T2-19. https://doi.org/10.1016/j.jpain.2013.06.006.Full Text Link to Item
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Ohrbach, Richard, Eric Bair, Roger B. Fillingim, Yoly Gonzalez, Sharon M. Gordon, Pei-Feng Lim, Margarete Ribeiro-Dasilva, et al. “Clinical orofacial characteristics associated with risk of first-onset TMD: the OPPERA prospective cohort study.” J Pain 14, no. 12 Suppl (December 2013): T33–50. https://doi.org/10.1016/j.jpain.2013.07.018.Full Text Link to Item
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Slade, Gary D., Roger B. Fillingim, Anne E. Sanders, Eric Bair, Joel D. Greenspan, Richard Ohrbach, Ronald Dubner, et al. “Summary of findings from the OPPERA prospective cohort study of incidence of first-onset temporomandibular disorder: implications and future directions.” J Pain 14, no. 12 Suppl (December 2013): T116–24. https://doi.org/10.1016/j.jpain.2013.09.010.Full Text Link to Item
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Smith, Shad B., Ellen Mir, Eric Bair, Gary D. Slade, Ronald Dubner, Roger B. Fillingim, Joel D. Greenspan, et al. “Genetic variants associated with development of TMD and its intermediate phenotypes: the genetic architecture of TMD in the OPPERA prospective cohort study.” J Pain 14, no. 12 Suppl (December 2013): T91-101.e1-3. https://doi.org/10.1016/j.jpain.2013.09.004.Full Text Link to Item
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Slade, Gary D., Shad B. Smith, Dmitri V. Zaykin, Inna E. Tchivileva, Dustin G. Gibson, Anton Yuryev, Ilya Mazo, et al. “Facial pain with localized and widespread manifestations: separate pathways of vulnerability.” Pain 154, no. 11 (November 2013): 2335–43. https://doi.org/10.1016/j.pain.2013.07.009.Full Text Link to Item
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Belfer, Inna, Samantha K. Segall, William R. Lariviere, Shad B. Smith, Feng Dai, Gary D. Slade, Naim U. Rashid, et al. “Pain modality- and sex-specific effects of COMT genetic functional variants.” Pain 154, no. 8 (August 2013): 1368–76. https://doi.org/10.1016/j.pain.2013.04.028.Full Text Link to Item
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Diatchenko, Luda, Roger B. Fillingim, Shad B. Smith, and William Maixner. “The phenotypic and genetic signatures of common musculoskeletal pain conditions.” Nat Rev Rheumatol 9, no. 6 (June 2013): 340–50. https://doi.org/10.1038/nrrheum.2013.43.Full Text Link to Item
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Monda, Keri L., Gary K. Chen, Kira C. Taylor, Cameron Palmer, Todd L. Edwards, Leslie A. Lange, Maggie C. Y. Ng, et al. “A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry.” Nat Genet 45, no. 6 (June 2013): 690–96. https://doi.org/10.1038/ng.2608.Full Text Link to Item
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Slade, Gary D., Anne E. Sanders, Eric Bair, Naomi Brownstein, Dawn Dampier, Charles Knott, Roger Fillingim, et al. “Preclinical episodes of orofacial pain symptoms and their association with health care behaviors in the OPPERA prospective cohort study.” Pain 154, no. 5 (May 2013): 750–60. https://doi.org/10.1016/j.pain.2013.01.014.Full Text Link to Item
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Sorge, Robert E., Tuan Trang, Ruslan Dorfman, Shad B. Smith, Simon Beggs, Jennifer Ritchie, Jean-Sebastien Austin, et al. “Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity.” Nat Med 18, no. 4 (March 25, 2012): 595–99. https://doi.org/10.1038/nm.2710.Full Text Link to Item
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Smith, Shad B., Dylan W. Maixner, Roger B. Fillingim, Gary Slade, Richard H. Gracely, Kirsten Ambrose, Dmitri V. Zaykin, et al. “Large candidate gene association study reveals genetic risk factors and therapeutic targets for fibromyalgia.” Arthritis Rheum 64, no. 2 (February 2012): 584–93. https://doi.org/10.1002/art.33338.Full Text Link to Item
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Neely, G Gregory, Shuan Rao, Michael Costigan, Norbert Mair, Ildiko Racz, Giedre Milinkeviciute, Arabella Meixner, et al. “Construction of a global pain systems network highlights phospholipid signaling as a regulator of heat nociception.” Plos Genet 8, no. 12 (2012): e1003071. https://doi.org/10.1371/journal.pgen.1003071.Full Text Link to Item
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Slade, Gary D., Mathew S. Conrad, Luda Diatchenko, Naim U. Rashid, Sheng Zhong, Shad Smith, Jesse Rhodes, et al. “Cytokine biomarkers and chronic pain: association of genes, transcription, and circulating proteins with temporomandibular disorders and widespread palpation tenderness.” Pain 152, no. 12 (December 2011): 2802–12. https://doi.org/10.1016/j.pain.2011.09.005.Full Text Link to Item
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Smith, Shad B., Dylan W. Maixner, Joel D. Greenspan, Ronald Dubner, Roger B. Fillingim, Richard Ohrbach, Charles Knott, et al. “Potential genetic risk factors for chronic TMD: genetic associations from the OPPERA case control study.” J Pain 12, no. 11 Suppl (November 2011): T92-101. https://doi.org/10.1016/j.jpain.2011.08.005.Full Text Link to Item
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Mogil, Jeffrey S., Robert E. Sorge, Michael L. LaCroix-Fralish, Shad B. Smith, Anny Fortin, Susana G. Sotocinal, Jennifer Ritchie, et al. “Pain sensitivity and vasopressin analgesia are mediated by a gene-sex-environment interaction.” Nat Neurosci 14, no. 12 (October 23, 2011): 1569–73. https://doi.org/10.1038/nn.2941.Full Text Link to Item
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“Corrigenda.” Brain 134, no. 7 (July 1, 2011): 2186–2186. https://doi.org/10.1093/brain/awq387.Full Text
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Neely, G Gregory, Andreas Hess, Michael Costigan, Alex C. Keene, Spyros Goulas, Michiel Langeslag, Robert S. Griffin, et al. “A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene.” Cell 143, no. 4 (November 12, 2010): 628–38. https://doi.org/10.1016/j.cell.2010.09.047.Full Text Link to Item
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Costigan, Michael, Inna Belfer, Robert S. Griffin, Feng Dai, Lee B. Barrett, Giovanni Coppola, Tianxia Wu, et al. “Multiple chronic pain states are associated with a common amino acid-changing allele in KCNS1.” Brain 133, no. 9 (September 2010): 2519–27. https://doi.org/10.1093/brain/awq195.Full Text Link to Item
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Tchivileva, Inna E., Pei Feng Lim, Shad B. Smith, Gary D. Slade, Luda Diatchenko, Samuel A. McLean, and William Maixner. “Effect of catechol-O-methyltransferase polymorphism on response to propranolol therapy in chronic musculoskeletal pain: a randomized, double-blind, placebo-controlled, crossover pilot study.” Pharmacogenet Genomics 20, no. 4 (April 2010): 239–48. https://doi.org/10.1097/FPC.0b013e328337f9ab.Full Text Link to Item
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Reimann, Frank, James J. Cox, Inna Belfer, Luda Diatchenko, Dmitri V. Zaykin, Duncan P. McHale, Joost P. H. Drenth, et al. “Pain perception is altered by a nucleotide polymorphism in SCN9A.” Proc Natl Acad Sci U S A 107, no. 11 (March 16, 2010): 5148–53. https://doi.org/10.1073/pnas.0913181107.Full Text Link to Item
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Lim, Pei Feng, Shad Smith, Kanokporn Bhalang, Gary D. Slade, and William Maixner. “Development of temporomandibular disorders is associated with greater bodily pain experience.” Clin J Pain 26, no. 2 (February 2010): 116–20. https://doi.org/10.1097/AJP.0b013e3181c507ef.Full Text Link to Item
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Kest, B., S. B. Smith, A. Schorscher-Petcu, J. -. S. Austin, J. Ritchie, G. Klein, G. C. Rossi, A. Fortin, and J. S. Mogil. “Gnao1 (G alphaO protein) is a likely genetic contributor to variation in physical dependence on opioids in mice.” Neuroscience 162, no. 4 (September 15, 2009): 1255–64. https://doi.org/10.1016/j.neuroscience.2009.05.027.Full Text Link to Item
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LaCroix-Fralish, Michael L., Gary Mo, Shad B. Smith, Susana G. Sotocinal, Jennifer Ritchie, Jean-Sebastien Austin, Kara Melmed, et al. “The beta3 subunit of the Na+,K+-ATPase mediates variable nociceptive sensitivity in the formalin test.” Pain 144, no. 3 (August 2009): 294–302. https://doi.org/10.1016/j.pain.2009.04.028.Full Text Link to Item
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Smith, Shad B., Cheryl L. Marker, Cydne Perry, Guochun Liao, Susana G. Sotocinal, Jean-Sebastien Austin, Kara Melmed, et al. “Quantitative trait locus and computational mapping identifies Kcnj9 (GIRK3) as a candidate gene affecting analgesia from multiple drug classes.” Pharmacogenet Genomics 18, no. 3 (March 2008): 231–41. https://doi.org/10.1097/FPC.0b013e3282f55ab2.Full Text Link to Item
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Mogil, Jeffrey S., Jennifer Ritchie, Susana G. Sotocinal, Shad B. Smith, Sylvie Croteau, Daniel J. Levitin, and Anna K. Naumova. “Screening for pain phenotypes: analysis of three congenic mouse strains on a battery of nine nociceptive assays.” Pain 126, no. 1–3 (December 15, 2006): 24–34. https://doi.org/10.1016/j.pain.2006.06.004.Full Text Link to Item
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Green, Amanda D., Katrina K. Young, Sonya G. Lehto, Shad B. Smith, and Jeffrey S. Mogil. “Influence of genotype, dose and sex on pruritogen-induced scratching behavior in the mouse.” Pain 124, no. 1–2 (September 2006): 50–58. https://doi.org/10.1016/j.pain.2006.03.023.Full Text Link to Item
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Langford, Dale J., Sara E. Crager, Zarrar Shehzad, Shad B. Smith, Susana G. Sotocinal, Jeremy S. Levenstadt, Mona Lisa Chanda, Daniel J. Levitin, and Jeffrey S. Mogil. “Social modulation of pain as evidence for empathy in mice.” Science 312, no. 5782 (June 30, 2006): 1967–70. https://doi.org/10.1126/science.1128322.Full Text Link to Item
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Mogil, Jeffrey S., Shad B. Smith, Meghan K. O’Reilly, and Gilles Plourde. “Influence of nociception and stress-induced antinociception on genetic variation in isoflurane anesthetic potency among mouse strains.” Anesthesiology 103, no. 4 (October 2005): 751–58. https://doi.org/10.1097/00000542-200510000-00013.Full Text Link to Item
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Mogil, Jeffrey S., Frank Miermeister, Frank Seifert, Kate Strasburg, Katharina Zimmermann, Heiko Reinold, Jean-Sebastien Austin, et al. “Variable sensitivity to noxious heat is mediated by differential expression of the CGRP gene.” Proc Natl Acad Sci U S A 102, no. 36 (September 6, 2005): 12938–43. https://doi.org/10.1073/pnas.0503264102.Full Text Link to Item
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Mogil, J. S., J. Ritchie, S. B. Smith, K. Strasburg, L. Kaplan, M. R. Wallace, R. R. Romberg, et al. “Melanocortin-1 receptor gene variants affect pain and mu-opioid analgesia in mice and humans.” J Med Genet 42, no. 7 (July 2005): 583–87. https://doi.org/10.1136/jmg.2004.027698.Full Text Link to Item
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Wilson, Sonya G., Shad B. Smith, Elissa J. Chesler, Kimberly A. Melton, Jeremiah J. Haas, Bryan Mitton, Kate Strasburg, Lawrence Hubert, Sandra L. Rodriguez-Zas, and Jeffrey S. Mogil. “The heritability of antinociception: common pharmacogenetic mediation of five neurochemically distinct analgesics.” J Pharmacol Exp Ther 304, no. 2 (February 2003): 547–59. https://doi.org/10.1124/jpet.102.041889.Full Text Link to Item
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Book Sections
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Smith, S. B. “Clinical pain phenotyping for omics studies.” In Genomics of Pain and Co-Morbid Symptoms, 49–71, 2020. https://doi.org/10.1007/978-3-030-21657-3_5.Full Text
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Meloto, C. B., S. Smith, W. Maixner, Z. Seltzer, and L. Diatchenko. “Genetic risk factors for orofacial pain: Insights from human experimental studies.” In Orofacial Pain, 2015.
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Smith, S. B., I. E. Tchivileva, W. Maixner, and L. Diatchenko. “Progress and challenges in genome-wide association studies of pain.” In Pain 2012 Refresher Courses: 14th World Congress on Pain, 2015.
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Diatchenko, L., S. B. Smith, and W. Maixner. “Translating Genetic Knowledge into Clinical Practice for Musculoskeletal Pain Conditions.” In Pain Genetics: Basic to Translational Science, 147–59, 2013. https://doi.org/10.1002/9781118398890.ch10.Full Text
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Smith, Shad B., and Jeffrey S. Mogil. “Tactile system and nociception.” In BEHAVIORAL GENETICS OF THE MOUSE, VOL 1: GENETICS OF BEHAVIORAL PHENOTYPES, 55–64, 2013.Link to Item
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Conference Papers
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Smith, Shad B. “Discovery of Novel Mechanisms for Idiopathic Pain Disorders Through Genome Wide Approaches.” In Faseb Journal, Vol. 33, 2019.Link to Item
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Smith, Shad B., William Maixner, Olafur S. Palsson, Miranda A. Van Tilburg, Motoyori Kanazawa, and William E. Whitehead. “FKBP5 Gene Is Associated With IBS Diagnosis.” In Gastroenterology, 146:S109–S109, 2014.Link to Item
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Smith, Shad B., Sara E. Crager, and Jeffrey S. Mogil. “Paclitaxel-induced neuropathic hypersensitivity in mice: responses in 10 inbred mouse strains.” In Life Sci, 74:2593–2604, 2004. https://doi.org/10.1016/j.lfs.2004.01.002.Full Text Link to Item
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- Scholarly, Clinical, & Service Activities
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Presentations & Appearances
- Association between INADL genetic variant and a subgroup with high risk for TMD in teh OPPERA study . 7th Scientific Meeting of the TMJ Association . The TMJ Association . 2014 2014
- Uncovering genetic risk factors for pain in the genomic era. Alan Edwards Centre for Research on Pain . McGill University. 2014 2014
- Human genetic association studies of comorbid chronic pain conditions. 6th Scientific Meeting of the TMJ Association . The TMJ Association . 2011 2011
- Target identification strategies in human association studies. 30th Annual Scientific Meeting . American Pain Society . 2011 2011
- Genetic approaches to pain variability in humans. 43rd Annual Winter Conference on Brain Research. 2010 2010
- Genetic variability and considerations for pain measurement in inbred and transgenic mice. 8th Annual Meeting of the INternational Behavioural and Neural Genetics Society . 2006 2006
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