Shad Benjamin Smith | Scholars@Duke

Shad Benjamin Smith
Assistant Professor in Anesthesiology

Dr. Shad Smith is an assistant professor in the Department of Anesthesiology and holds a faculty position in the Center for Translational Pain Medicine (CTPM). Dr. Smith also has an adjunct appointment at the University of North Carolina at Chapel Hill, as part of the Center for Pain Research and Innovation (CPRI). He earned his bachelor’s degree in psychology with minors in chemistry and zoology from Brigham Young University, before moving on to graduate school.

In 2006, he graduated with a doctorate in psychology with an emphasis in behavioral neuroscience. Following his time at McGill, Dr. Smith accepted a post-doctoral fellowship in the CPRI at the UNC School of Dentistry. He received a Ruth L. Kirschstein National Research Service Award in 2008 to study the role of alpha adrenergic mechanisms in chronic orofacial pain. He joined the faculty at UNC as a research assistant professor in 2011. Dr. Smith has also served since 2007 as a research consultant, and since 2010 as the Director of Bioinformatics, for Algynomics, Inc., a Chapel Hill-based biotech firm spun off from research activities within the UNC School of Dentistry.

Dr. Smith joined the faculty at Duke University in 2016, where he continues his work with genetics of pain disorders. The primary focus of his research career has been the search for genetic variation that contributes to greater pain sensitivity and increased risk for chronic pain disease. He has worked for over a decade with genomic techniques, including both quantitative trait locus (QTL) mapping in the mouse and genetic association in human pain cohorts, investigating a number of pain-related diseases and phenotypes. Dr. Smith has published over 40 journal articles and book chapters, and presented his work at several international meetings. His work with projects such as the OPPERA (Orofacial Pain: Prospective Evaluation and Risk Assessment) study has resulted in a number of novel genes being recognized as genetic risk factors for pain.

Current Appointments & Affiliations

Assistant Professor in Anesthesiology, Anesthesiology, Clinical Science Departments 2015

Contact Information

shad.smith@duke.edu

Background
Education, Training, & Certifications
- Ph.D., McGill University (Canada) 2007
Recognition
Awards & Honors
Expertise
Subject Headings
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Smith, SB, Parisien, M, Bair, E, Belfer, I, Chabot-Doré, A-J, Gris, P, Khoury, S, Tansley, S, Torosyan, Y, Zaykin, DV, Bernhardt, O, de Oliveira Serrano, P, Gracely, RH, Jain, D, Järvelin, M-R, Kaste, LM, Kerr, KF, Kocher, T, Lähdesmäki, R, Laniado, N, Laurie, CC, Laurie, CA, Männikkö, M, Meloto, CB, Nackley, AG, Nelson, SC, Pesonen, P, Ribeiro-Dasilva, MC, Rizzatti-Barbosa, CM, Sanders, AE, Schwahn, C, Sipilä, K, Sofer, T, Teumer, A, Mogil, JS, Fillingim, RB, Greenspan, JD, Ohrbach, R, Slade, GD, Maixner, W, and Diatchenko, L. "Genome-wide association reveals contribution of MRAS to painful temporomandibular disorder in males." Pain (November 13, 2018). Full Text Open Access Copy
  - Zhuang, GZ, Upadhyay, U, Tong, X, Kang, Y, Erasso, DM, Fu, ES, Sarantopoulos, KD, Martin, ER, Wiltshire, T, Diatchenko, L, Smith, SB, Maixner, W, and Levitt, RC. "Human carbonic anhydrase-8 AAV8 gene therapy inhibits nerve growth factor signaling producing prolonged analgesia and anti-hyperalgesia in mice." Gene Therapy 25, no. 4 (July 2018): 297-311. Full Text
  - Sigurdsson, MI, Waldron, NH, Bortsov, AV, Smith, SB, and Maixner, W. "Genomics of Cardiovascular Measures of Autonomic Tone." Journal of Cardiovascular Pharmacology 71, no. 3 (March 2018): 180-191. Full Text
  - Fu, ES, Erasso, DM, Zhuang, GZ, Upadhyay, U, Ozdemir, M, Wiltshire, T, Sarantopoulos, KD, Smith, SB, Maixner, W, Martin, ER, and Levitt, RC. "Impact of human CA8 on thermal antinociception in relation to morphine equivalence in mice." Neuroreport 28, no. 18 (December 2017): 1215-1220. Full Text
  - Levitt, RC, Zhuang, GY, Kang, Y, Erasso, DM, Upadhyay, U, Ozdemir, M, Fu, ES, Sarantopoulos, KD, Smith, SB, Maixner, W, Diatchenko, L, Martin, ER, and Wiltshire, T. "Car8 dorsal root ganglion expression and genetic regulation of analgesic responses are associated with a cis-eQTL in mice." Mammalian Genome : Official Journal of the International Mammalian Genome Society 28, no. 9-10 (October 2017): 407-415. Full Text
  - Martin, LJ, Smith, SB, Khoutorsky, A, Magnussen, CA, Samoshkin, A, Sorge, RE, Cho, C, Yosefpour, N, Sivaselvachandran, S, Tohyama, S, Cole, T, Khuong, TM, Mir, E, Gibson, DG, Wieskopf, JS, Sotocinal, SG, Austin, JS, Meloto, CB, Gitt, JH, Gkogkas, C, Sonenberg, N, Greenspan, JD, Fillingim, RB, Ohrbach, R, Slade, GD, Knott, C, Dubner, R, Nackley, AG, Ribeiro-da-Silva, A, Neely, GG, Maixner, W, Zaykin, DV, Mogil, JS, and Diatchenko, L. "Epiregulin and EGFR interactions are involved in pain processing." The Journal of Clinical Investigation 127, no. 9 (September 2017): 3353-3366. Full Text
  - Zillikens, MC, Demissie, S, Hsu, Y-H, Yerges-Armstrong, LM, Chou, W-C, Stolk, L, Livshits, G, Broer, L, Johnson, T, Koller, DL, Kutalik, Z, Luan, J, Malkin, I, Ried, JS, Smith, AV, Thorleifsson, G, Vandenput, L, Hua Zhao, J, Zhang, W, Aghdassi, A, Åkesson, K, Amin, N, Baier, LJ, Barroso, I, Bennett, DA, Bertram, L, Biffar, R, Bochud, M, Boehnke, M, Borecki, IB, Buchman, AS, Byberg, L, Campbell, H, Campos Obanda, N, Cauley, JA, Cawthon, PM, Cederberg, H, Chen, Z, Cho, NH, Jin Choi, H, Claussnitzer, M, Collins, F, Cummings, SR, De Jager, PL, Demuth, I, Dhonukshe-Rutten, RAM, Diatchenko, L, Eiriksdottir, G, Enneman, AW, Erdos, M, Eriksson, JG, Eriksson, J, Estrada, K, Evans, DS, Feitosa, MF, Fu, M, Garcia, M, Gieger, C, Girke, T, Glazer, NL, Grallert, H, Grewal, J, Han, B-G, Hanson, RL, Hayward, C, Hofman, A, Hoffman, EP, Homuth, G, Hsueh, W-C, Hubal, MJ, Hubbard, A, Huffman, KM, Husted, LB, Illig, T, Ingelsson, E, Ittermann, T, Jansson, J-O, Jordan, JM, Jula, A, Karlsson, M, Khaw, K-T, Kilpeläinen, TO, Klopp, N, Kloth, JSL, Koistinen, HA, Kraus, WE, Kritchevsky, S, Kuulasmaa, T, Kuusisto, J, Laakso, M, Lahti, J, Lang, T, Langdahl, BL, Launer, LJ, Lee, J-Y, Lerch, MM, Lewis, JR, Lind, L, Lindgren, C, Liu, Y, Liu, T, Liu, Y, Ljunggren, Ö, Lorentzon, M, Luben, RN, Maixner, W, McGuigan, FE, Medina-Gomez, C, Meitinger, T, Melhus, H, Mellström, D, Melov, S, Michaëlsson, K, Mitchell, BD, Morris, AP, Mosekilde, L, Newman, A, Nielson, CM, O'Connell, JR, Oostra, BA, Orwoll, ES, Palotie, A, Parker, SCJ, Peacock, M, Perola, M, Peters, A, Polasek, O, Prince, RL, Räikkönen, K, Ralston, SH, Ripatti, S, Robbins, JA, Rotter, JI, Rudan, I, Salomaa, V, Satterfield, S, Schadt, EE, Schipf, S, Scott, L, Sehmi, J, Shen, J, Soo Shin, C, Sigurdsson, G, Smith, S, Soranzo, N, Stančáková, A, Steinhagen-Thiessen, E, Streeten, EA, Styrkarsdottir, U, Swart, KMA, Tan, S-T, Tarnopolsky, MA, Thompson, P, Thomson, CA, Thorsteinsdottir, U, Tikkanen, E, Tranah, GJ, Tuomilehto, J, van Schoor, NM, Verma, A, Vollenweider, P, Völzke, H, Wactawski-Wende, J, Walker, M, Weedon, MN, Welch, R, Wichmann, H-E, Widen, E, Williams, FMK, Wilson, JF, Wright, NC, Xie, W, Yu, L, Zhou, Y, Chambers, JC, Döring, A, van Duijn, CM, Econs, MJ, Gudnason, V, Kooner, JS, Psaty, BM, Spector, TD, Stefansson, K, Rivadeneira, F, Uitterlinden, AG, Wareham, NJ, Ossowski, V, Waterworth, D, Loos, RJF, Karasik, D, Harris, TB, Ohlsson, C, and Kiel, DP. "Large meta-analysis of genome-wide association studies identifies five loci for lean body mass." Nature Communications 8, no. 1 (July 19, 2017): 80-null. Full Text
  - Parisien, M, Khoury, S, Chabot-Doré, A-J, Sotocinal, SG, Slade, GD, Smith, SB, Fillingim, RB, Ohrbach, R, Greenspan, JD, Maixner, W, Mogil, JS, Belfer, I, and Diatchenko, L. "Effect of Human Genetic Variability on Gene Expression in Dorsal Root Ganglia and Association with Pain Phenotypes." Cell Reports 19, no. 9 (May 2017): 1940-1952. Full Text
  - Sanders, AE, Jain, D, Sofer, T, Kerr, KF, Laurie, CC, Shaffer, JR, Marazita, ML, Kaste, LM, Slade, GD, Fillingim, RB, Ohrbach, R, Maixner, W, Kocher, T, Bernhardt, O, Teumer, A, Schwahn, C, Sipilä, K, Lähdesmäki, R, Männikkö, M, Pesonen, P, Järvelin, M, Rizzatti-Barbosa, CM, Meloto, CB, Ribeiro-Dasilva, M, Diatchenko, L, Serrano, P, and Smith, SB. "GWAS Identifies New Loci for Painful Temporomandibular Disorder: Hispanic Community Health Study/Study of Latinos." Journal of Dental Research 96, no. 3 (March 2017): 277-284. Full Text Open Access Copy
  - Levitt, AE, Galor, A, Chowdhury, AR, Felix, ER, Sarantopoulos, CD, Zhuang, GY, Patin, D, Maixner, W, Smith, SB, Martin, ER, and Levitt, RC. "Evidence that Dry Eye Represents a Chronic Overlapping Pain Condition." Molecular Pain 13 (January 2017): 1744806917729306-null. (Review) Full Text
  - Maixner, W, Fillingim, RB, Williams, DA, Smith, SB, and Slade, GD. "Overlapping Chronic Pain Conditions: Implications for Diagnosis and Classification." The Journal of Pain : Official Journal of the American Pain Society 17, no. 9 Suppl (September 2016): T93-T107. (Review) Full Text
  - Slade, GD, Ohrbach, R, Greenspan, JD, Fillingim, RB, Bair, E, Sanders, AE, Dubner, R, Diatchenko, L, Meloto, CB, Smith, S, and Maixner, W. "Painful Temporomandibular Disorder: Decade of Discovery from OPPERA Studies." Journal of Dental Research 95, no. 10 (September 2016): 1084-1092. (Review) Full Text
  - Bair, E, Gaynor, S, Slade, GD, Ohrbach, R, Fillingim, RB, Greenspan, JD, Dubner, R, Smith, SB, Diatchenko, L, and Maixner, W. "Identification of clusters of individuals relevant to temporomandibular disorders and other chronic pain conditions: the OPPERA study." Pain 157, no. 6 (June 2016): 1266-1278. Full Text
  - Meloto, CB, Bortsov, AV, Bair, E, Helgeson, E, Ostrom, C, Smith, SB, Dubner, R, Slade, GD, Fillingim, RB, Greenspan, JD, Ohrbach, R, Maixner, W, McLean, SA, and Diatchenko, L. "Modification of COMT-dependent pain sensitivity by psychological stress and sex." Pain 157, no. 4 (April 2016): 858-867. Full Text
  - Ciszek, BP, Khan, AA, Dang, H, Slade, GD, Smith, S, Bair, E, Maixner, W, Zolnoun, D, and Nackley, AG. "MicroRNA expression profiles differentiate chronic pain condition subtypes." Translational research : the journal of laboratory and clinical medicine 166, no. 6 (December 2015): 706-720.e11. Full Text
  - Hsu, Y-H, Liu, Y, Hannan, MT, Maixner, W, Smith, SB, Diatchenko, L, Golightly, YM, Menz, HB, Kraus, VB, Doherty, M, Wilson, AG, and Jordan, JM. "Genome-wide association meta-analyses to identify common genetic variants associated with hallux valgus in Caucasian and African Americans." Journal of medical genetics 52, no. 11 (November 2015): 762-769. Full Text
  - Meloto, CB, Segall, SK, Smith, S, Parisien, M, Shabalina, SA, Rizzatti-Barbosa, CM, Gauthier, J, Tsao, D, Convertino, M, Piltonen, MH, Slade, GD, Fillingim, RB, Greenspan, JD, Ohrbach, R, Knott, C, Maixner, W, Zaykin, D, Dokholyan, NV, Reenilä, I, Männistö, PT, and Diatchenko, L. "COMT gene locus: new functional variants." Pain 156, no. 10 (October 2015): 2072-2083. Full Text
  - Slade, GD, Sanders, AE, Ohrbach, R, Bair, E, Maixner, W, Greenspan, JD, Fillingim, RB, Smith, S, and Diatchenko, L. "COMT Diplotype Amplifies Effect of Stress on Risk of Temporomandibular Pain." Journal of Dental Research 94, no. 9 (September 2015): 1187-1195. Full Text
  - Wieskopf, JS, Mathur, J, Limapichat, W, Post, MR, Al-Qazzaz, M, Sorge, RE, Martin, LJ, Zaykin, DV, Smith, SB, Freitas, K, Austin, J-S, Dai, F, Zhang, J, Marcovitz, J, Tuttle, AH, Slepian, PM, Clarke, S, Drenan, RM, Janes, J, Al Sharari, S, Segall, SK, Aasvang, EK, Lai, W, Bittner, R, Richards, CI, Slade, GD, Kehlet, H, Walker, J, Maskos, U, Changeux, J-P, Devor, M, Maixner, W, Diatchenko, L, Belfer, I, Dougherty, DA, Su, AI, Lummis, SCR, Imad Damaj, M, Lester, HA, Patapoutian, A, and Mogil, JS. "The nicotinic α6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors." Science Translational Medicine 7, no. 287 (May 2015): 287ra72-null. Full Text
  - Zhuang, GZ, Keeler, B, Grant, J, Bianchi, L, Fu, ES, Zhang, YP, Erasso, DM, Cui, J-G, Wiltshire, T, Li, Q, Hao, S, Sarantopoulos, KD, Candiotti, K, Wishnek, SM, Smith, SB, Maixner, W, Diatchenko, L, Martin, ER, and Levitt, RC. "Carbonic anhydrase-8 regulates inflammatory pain by inhibiting the ITPR1-cytosolic free calcium pathway." Plos One 10, no. 3 (January 2015): e0118273-null. Full Text
  - Smith, SB, Reenilä, I, Männistö, PT, Slade, GD, Maixner, W, Diatchenko, L, and Nackley, AG. "Epistasis between polymorphisms in COMT, ESR1, and GCH1 influences COMT enzyme activity and pain." Pain 155, no. 11 (November 2014): 2390-2399. Full Text
  - Bair, E, Brownstein, NC, Ohrbach, R, Greenspan, JD, Dubner, R, Fillingim, RB, Maixner, W, Smith, SB, Diatchenko, L, Gonzalez, Y, Gordon, SM, Lim, P-F, Ribeiro-Dasilva, M, Dampier, D, Knott, C, and Slade, GD. "Study protocol, sample characteristics, and loss to follow-up: the OPPERA prospective cohort study." The journal of pain : official journal of the American Pain Society 14, no. 12 Suppl (December 2013): T2-19. Full Text
  - Ohrbach, R, Bair, E, Fillingim, RB, Gonzalez, Y, Gordon, SM, Lim, P-F, Ribeiro-Dasilva, M, Diatchenko, L, Dubner, R, Greenspan, JD, Knott, C, Maixner, W, Smith, SB, and Slade, GD. "Clinical orofacial characteristics associated with risk of first-onset TMD: the OPPERA prospective cohort study." The Journal of Pain : Official Journal of the American Pain Society 14, no. 12 Suppl (December 2013): T33-T50. Full Text
  - Slade, GD, Fillingim, RB, Sanders, AE, Bair, E, Greenspan, JD, Ohrbach, R, Dubner, R, Diatchenko, L, Smith, SB, Knott, C, and Maixner, W. "Summary of findings from the OPPERA prospective cohort study of incidence of first-onset temporomandibular disorder: implications and future directions." The journal of pain : official journal of the American Pain Society 14, no. 12 Suppl (December 2013): T116-T124. Full Text
  - Smith, SB, Mir, E, Bair, E, Slade, GD, Dubner, R, Fillingim, RB, Greenspan, JD, Ohrbach, R, Knott, C, Weir, B, Maixner, W, and Diatchenko, L. "Genetic variants associated with development of TMD and its intermediate phenotypes: the genetic architecture of TMD in the OPPERA prospective cohort study." The journal of pain : official journal of the American Pain Society 14, no. 12 Suppl (December 2013): T91-101.e1-3-. Full Text
  - Slade, GD, Smith, SB, Zaykin, DV, Tchivileva, IE, Gibson, DG, Yuryev, A, Mazo, I, Bair, E, Fillingim, R, Ohrbach, R, Greenspan, J, Maixner, W, and Diatchenko, L. "Facial pain with localized and widespread manifestations: separate pathways of vulnerability." Pain 154, no. 11 (November 2013): 2335-2343. Full Text
  - Belfer, I, Segall, SK, Lariviere, WR, Smith, SB, Dai, F, Slade, GD, Rashid, NU, Mogil, JS, Campbell, CM, Edwards, RR, Liu, Q, Bair, E, Maixner, W, and Diatchenko, L. "Pain modality- and sex-specific effects of COMT genetic functional variants." Pain 154, no. 8 (August 2013): 1368-1376. Full Text
  - Diatchenko, L, Fillingim, RB, Smith, SB, and Maixner, W. "The phenotypic and genetic signatures of common musculoskeletal pain conditions." Nature Reviews. Rheumatology 9, no. 6 (June 2013): 340-350. (Review) Full Text
  - Monda, KL, Chen, GK, Taylor, KC, Palmer, C, Edwards, TL, Lange, LA, Ng, MCY, Adeyemo, AA, Allison, MA, Bielak, LF, Chen, G, Graff, M, Irvin, MR, Rhie, SK, Li, G, Liu, Y, Liu, Y, Lu, Y, Nalls, MA, Sun, YV, Wojczynski, MK, Yanek, LR, Aldrich, MC, Ademola, A, Amos, CI, Bandera, EV, Bock, CH, Britton, A, Broeckel, U, Cai, Q, Caporaso, NE, Carlson, CS, Carpten, J, Casey, G, Chen, W-M, Chen, F, Chen, Y-DI, Chiang, CWK, Coetzee, GA, Demerath, E, Deming-Halverson, SL, Driver, RW, Dubbert, P, Feitosa, MF, Feng, Y, Freedman, BI, Gillanders, EM, Gottesman, O, Guo, X, Haritunians, T, Harris, T, Harris, CC, Hennis, AJM, Hernandez, DG, McNeill, LH, Howard, TD, Howard, BV, Howard, VJ, Johnson, KC, Kang, SJ, Keating, BJ, Kolb, S, Kuller, LH, Kutlar, A, Langefeld, CD, Lettre, G, Lohman, K, Lotay, V, Lyon, H, Manson, JE, Maixner, W, Meng, YA, Monroe, KR, Morhason-Bello, I, Murphy, AB, Mychaleckyj, JC, Nadukuru, R, Nathanson, KL, Nayak, U, N'diaye, A, Nemesure, B, Wu, S-Y, Leske, MC, Neslund-Dudas, C, Neuhouser, M, Nyante, S, Ochs-Balcom, H, Ogunniyi, A, Ogundiran, TO, Ojengbede, O, Olopade, OI, Palmer, JR, Ruiz-Narvaez, EA, Palmer, ND, Press, MF, Rampersaud, E, Rasmussen-Torvik, LJ, Rodriguez-Gil, JL, Salako, B, Schadt, EE, Schwartz, AG, Shriner, DA, Siscovick, D, Smith, SB, Wassertheil-Smoller, S, Speliotes, EK, Spitz, MR, Sucheston, L, Taylor, H, Tayo, BO, Tucker, MA, Van Den Berg, DJ, Edwards, DRV, Wang, Z, Wiencke, JK, Winkler, TW, Witte, JS, Wrensch, M, Wu, X, Yang, JJ, Levin, AM, Young, TR, Zakai, NA, Cushman, M, Zanetti, KA, Zhao, JH, Zhao, W, Zheng, Y, Zhou, J, Ziegler, RG, Zmuda, JM, Fernandes, JK, Gilkeson, GS, Kamen, DL, Hunt, KJ, Spruill, IJ, Ambrosone, CB, Ambs, S, Arnett, DK, Atwood, L, Becker, DM, Berndt, SI, Bernstein, L, Blot, WJ, Borecki, IB, Bottinger, EP, Bowden, DW, Burke, G, Chanock, SJ, Cooper, RS, Ding, J, Duggan, D, Evans, MK, Fox, C, Garvey, WT, Bradfield, JP, Hakonarson, H, Grant, SFA, Hsing, A, Chu, L, Hu, JJ, Huo, D, Ingles, SA, John, EM, Jordan, JM, Kabagambe, EK, Kardia, SLR, Kittles, RA, Goodman, PJ, Klein, EA, Kolonel, LN, Le Marchand, L, Liu, S, McKnight, B, Millikan, RC, Mosley, TH, Padhukasahasram, B, Williams, LK, Patel, SR, Peters, U, Pettaway, CA, Peyser, PA, Psaty, BM, Redline, S, Rotimi, CN, Rybicki, BA, Sale, MM, Schreiner, PJ, Signorello, LB, Singleton, AB, Stanford, JL, Strom, SS, Thun, MJ, Vitolins, M, Zheng, W, Moore, JH, Williams, SM, Ketkar, S, Zhu, X, Zonderman, AB, NABEC Consortium, , UKBEC Consortium, , BioBank Japan Project, , AGEN Consortium, , Kooperberg, C, Papanicolaou, GJ, Henderson, BE, Reiner, AP, Hirschhorn, JN, Loos, RJF, North, KE, and Haiman, CA. "A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry." Nature Genetics 45, no. 6 (June 2013): 690-696. Full Text
  - Slade, GD, Sanders, AE, Bair, E, Brownstein, N, Dampier, D, Knott, C, Fillingim, R, Maixner, WO, Smith, S, Greenspan, J, Dubner, R, and Ohrbach, R. "Preclinical episodes of orofacial pain symptoms and their association with health care behaviors in the OPPERA prospective cohort study." Pain 154, no. 5 (May 2013): 750-760. Full Text
  - Sorge, RE, Trang, T, Dorfman, R, Smith, SB, Beggs, S, Ritchie, J, Austin, J-S, Zaykin, DV, Vander Meulen, H, Costigan, M, Herbert, TA, Yarkoni-Abitbul, M, Tichauer, D, Livneh, J, Gershon, E, Zheng, M, Tan, K, John, SL, Slade, GD, Jordan, J, Woolf, CJ, Peltz, G, Maixner, W, Diatchenko, L, Seltzer, Z, Salter, MW, and Mogil, JS. "Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity." Nature Medicine 18, no. 4 (March 25, 2012): 595-599. Full Text
  - Smith, SB, Maixner, DW, Fillingim, RB, Slade, G, Gracely, RH, Ambrose, K, Zaykin, DV, Hyde, C, John, S, Tan, K, Maixner, W, and Diatchenko, L. "Large candidate gene association study reveals genetic risk factors and therapeutic targets for fibromyalgia." Arthritis and Rheumatism 64, no. 2 (February 2012): 584-593. Full Text
  - Neely, GG, Rao, S, Costigan, M, Mair, N, Racz, I, Milinkeviciute, G, Meixner, A, Nayanala, S, Griffin, RS, Belfer, I, Dai, F, Smith, S, Diatchenko, L, Marengo, S, Haubner, BJ, Novatchkova, M, Gibson, D, Maixner, W, Pospisilik, JA, Hirsch, E, Whishaw, IQ, Zimmer, A, Gupta, V, Sasaki, J, Kanaho, Y, Sasaki, T, Kress, M, Woolf, CJ, and Penninger, JM. "Construction of a global pain systems network highlights phospholipid signaling as a regulator of heat nociception." Plos Genetics 8, no. 12 (January 2012): e1003071-null. Full Text
  - Slade, GD, Conrad, MS, Diatchenko, L, Rashid, NU, Zhong, S, Smith, S, Rhodes, J, Medvedev, A, Makarov, S, Maixner, W, and Nackley, AG. "Cytokine biomarkers and chronic pain: association of genes, transcription, and circulating proteins with temporomandibular disorders and widespread palpation tenderness." Pain 152, no. 12 (December 2011): 2802-2812. Full Text
  - Smith, SB, Maixner, DW, Greenspan, JD, Dubner, R, Fillingim, RB, Ohrbach, R, Knott, C, Slade, GD, Bair, E, Gibson, DG, Zaykin, DV, Weir, BS, Maixner, W, and Diatchenko, L. "Potential genetic risk factors for chronic TMD: genetic associations from the OPPERA case control study." The Journal of Pain : Official Journal of the American Pain Society 12, no. 11 Suppl (November 2011): T92-101. Full Text
  - Mogil, JS, Sorge, RE, LaCroix-Fralish, ML, Smith, SB, Fortin, A, Sotocinal, SG, Ritchie, J, Austin, J-S, Schorscher-Petcu, A, Melmed, K, Czerminski, J, Bittong, RA, Mokris, JB, Neubert, JK, Campbell, CM, Edwards, RR, Campbell, JN, Crawley, JN, Lariviere, WR, Wallace, MR, Sternberg, WF, Balaban, CD, Belfer, I, and Fillingim, RB. "Pain sensitivity and vasopressin analgesia are mediated by a gene-sex-environment interaction." Nature Neuroscience 14, no. 12 (October 23, 2011): 1569-1573. Full Text
  - Neely, GG, Hess, A, Costigan, M, Keene, AC, Goulas, S, Langeslag, M, Griffin, RS, Belfer, I, Dai, F, Smith, SB, Diatchenko, L, Gupta, V, Xia, C-P, Amann, S, Kreitz, S, Heindl-Erdmann, C, Wolz, S, Ly, CV, Arora, S, Sarangi, R, Dan, D, Novatchkova, M, Rosenzweig, M, Gibson, DG, Truong, D, Schramek, D, Zoranovic, T, Cronin, SJF, Angjeli, B, Brune, K, Dietzl, G, Maixner, W, Meixner, A, Thomas, W, Pospisilik, JA, Alenius, M, Kress, M, Subramaniam, S, Garrity, PA, Bellen, HJ, Woolf, CJ, and Penninger, JM. "A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene." Cell 143, no. 4 (November 2010): 628-638. Full Text
  - Costigan, M, Belfer, I, Griffin, RS, Dai, F, Barrett, LB, Coppola, G, Wu, T, Kiselycznyk, C, Poddar, M, Lu, Y, Diatchenko, L, Smith, S, Cobos, EJ, Zaykin, D, Allchorne, A, Gershon, E, Livneh, J, Shen, P-H, Nikolajsen, L, Karppinen, J, Männikkö, M, Kelempisioti, A, Goldman, D, Maixner, W, Geschwind, DH, Max, MB, Seltzer, Z, and Woolf, CJ. "Multiple chronic pain states are associated with a common amino acid-changing allele in KCNS1." Brain : a Journal of Neurology 133, no. 9 (September 2010): 2519-2527. Full Text
  - Tchivileva, IE, Lim, PF, Smith, SB, Slade, GD, Diatchenko, L, McLean, SA, and Maixner, W. "Effect of catechol-O-methyltransferase polymorphism on response to propranolol therapy in chronic musculoskeletal pain: a randomized, double-blind, placebo-controlled, crossover pilot study." Pharmacogenetics and Genomics 20, no. 4 (April 2010): 239-248. Full Text
  - Reimann, F, Cox, JJ, Belfer, I, Diatchenko, L, Zaykin, DV, McHale, DP, Drenth, JPH, Dai, F, Wheeler, J, Sanders, F, Wood, L, Wu, T-X, Karppinen, J, Nikolajsen, L, Männikkö, M, Max, MB, Kiselycznyk, C, Poddar, M, Te Morsche, RHM, Smith, S, Gibson, D, Kelempisioti, A, Maixner, W, Gribble, FM, and Woods, CG. "Pain perception is altered by a nucleotide polymorphism in SCN9A." Proceedings of the National Academy of Sciences of the United States of America 107, no. 11 (March 8, 2010): 5148-5153. Full Text
  - Lim, PF, Smith, S, Bhalang, K, Slade, GD, and Maixner, W. "Development of temporomandibular disorders is associated with greater bodily pain experience." The Clinical Journal of Pain 26, no. 2 (February 2010): 116-120. Full Text
  - Kest, B, Smith, SB, Schorscher-Petcu, A, Austin, J-S, Ritchie, J, Klein, G, Rossi, GC, Fortin, A, and Mogil, JS. "Gnao1 (G alphaO protein) is a likely genetic contributor to variation in physical dependence on opioids in mice." Neuroscience 162, no. 4 (September 2009): 1255-1264. Full Text
  - LaCroix-Fralish, ML, Mo, G, Smith, SB, Sotocinal, SG, Ritchie, J, Austin, J-S, Melmed, K, Schorscher-Petcu, A, Laferriere, AC, Lee, TH, Romanovsky, D, Liao, G, Behlke, MA, Clark, DJ, Peltz, G, Séguéla, P, Dobretsov, M, and Mogil, JS. "The beta3 subunit of the Na+,K+-ATPase mediates variable nociceptive sensitivity in the formalin test." Pain 144, no. 3 (August 2009): 294-302. Full Text
  - Smith, SB, Marker, CL, Perry, C, Liao, G, Sotocinal, SG, Austin, J-S, Melmed, K, Clark, JD, Peltz, G, Wickman, K, and Mogil, JS. "Quantitative trait locus and computational mapping identifies Kcnj9 (GIRK3) as a candidate gene affecting analgesia from multiple drug classes." Pharmacogenetics and genomics 18, no. 3 (March 2008): 231-241. Full Text
  - Mogil, JS, Ritchie, J, Sotocinal, SG, Smith, SB, Croteau, S, Levitin, DJ, and Naumova, AK. "Screening for pain phenotypes: analysis of three congenic mouse strains on a battery of nine nociceptive assays." Pain 126, no. 1-3 (December 2006): 24-34. Full Text
  - Green, AD, Young, KK, Lehto, SG, Smith, SB, and Mogil, JS. "Influence of genotype, dose and sex on pruritogen-induced scratching behavior in the mouse." Pain 124, no. 1-2 (September 2006): 50-58. Full Text
  - Langford, DJ, Crager, SE, Shehzad, Z, Smith, SB, Sotocinal, SG, Levenstadt, JS, Chanda, ML, Levitin, DJ, and Mogil, JS. "Social modulation of pain as evidence for empathy in mice." Science (New York, N.Y.) 312, no. 5782 (June 2006): 1967-1970. Full Text
  - Mogil, JS, Smith, SB, O'Reilly, MK, and Plourde, G. "Influence of nociception and stress-induced antinociception on genetic variation in isoflurane anesthetic potency among mouse strains." Anesthesiology 103, no. 4 (October 2005): 751-758. Full Text
  - Mogil, JS, Miermeister, F, Seifert, F, Strasburg, K, Zimmermann, K, Reinold, H, Austin, J-S, Bernardini, N, Chesler, EJ, Hofmann, HA, Hordo, C, Messlinger, K, Nemmani, KVS, Rankin, AL, Ritchie, J, Siegling, A, Smith, SB, Sotocinal, S, Vater, A, Lehto, SG, Klussmann, S, Quirion, R, Michaelis, M, Devor, M, and Reeh, PW. "Variable sensitivity to noxious heat is mediated by differential expression of the CGRP gene." Proceedings of the National Academy of Sciences of the United States of America 102, no. 36 (September 2005): 12938-12943. Full Text
  - Mogil, JS, Ritchie, J, Smith, SB, Strasburg, K, Kaplan, L, Wallace, MR, Romberg, RR, Bijl, H, Sarton, EY, Fillingim, RB, and Dahan, A. "Melanocortin-1 receptor gene variants affect pain and mu-opioid analgesia in mice and humans." Journal of medical genetics 42, no. 7 (July 2005): 583-587. Full Text
  - Wilson, SG, Smith, SB, Chesler, EJ, Melton, KA, Haas, JJ, Mitton, B, Strasburg, K, Hubert, L, Rodriguez-Zas, SL, and Mogil, JS. "The heritability of antinociception: common pharmacogenetic mediation of five neurochemically distinct analgesics." The Journal of pharmacology and experimental therapeutics 304, no. 2 (February 2003): 547-559. Full Text
- Book Sections
  - Meloto, CB, Smith, S, Maixner, W, Seltzer, Z, and Diatchenko, L. "Genetic risk factors for orofacial pain: Insights from human experimental studies." In Orofacial Pain. June 1, 2015.
  - Smith, SB, Tchivileva, IE, Maixner, W, and Diatchenko, L. "Progress and challenges in genome-wide association studies of pain." In Pain 2012 Refresher Courses: 14th World Congress on Pain. June 1, 2015.
  - Diatchenko, L, Smith, SB, and Maixner, W. "Translating Genetic Knowledge into Clinical Practice for Musculoskeletal Pain Conditions." In Pain Genetics: Basic to Translational Science, 147-159. November 25, 2013. Full Text
- Conference Papers
  - Smith, SB, Crager, SE, and Mogil, JS. "Paclitaxel-induced neuropathic hypersensitivity in mice: responses in 10 inbred mouse strains." April 2004. Full Text
Scholarly, Clinical, & Service Activities
Presentations & Appearances

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.

Education, Training, & Certifications

Awards & Honors

Subject Headings

Selected Publications

Academic Articles

Book Sections

Conference Papers

Presentations & Appearances