Scholars@Duke
Shakthi Unnithan

Selected Publications

MRI Predictors of Cognitive Function After Lacunar Infarction.

Journal Article Stroke · July 2025 BACKGROUND: Poststroke cognitive impairment is associated with disability and decreased quality of life. We assessed whether individual or collective magnetic resonance imaging (MRI) biomarkers can aid in predicting cognitive impairment after lacunar infar ... Full text Link to item Cite

Medicaid Expansion, Uninsurance Rates, and Catastrophic Costs at the Time of Emergency Gynecologic Surgery.

Journal Article Obstet Gynecol · April 1, 2025 OBJECTIVE: To estimate the effect of Medicaid expansion on uninsurance rates and catastrophic charges from emergency surgical management of ectopic pregnancy and ovarian torsion using difference-in-difference analysis and to evaluate for racial and ethnic ... Full text Open Access Link to item Cite

Anemia Biomarkers in Pregnant People with Pyelonephritis.

Journal Article Am J Perinatol · March 27, 2025 Anemia is observed in 30% of pregnancies with pyelonephritis, yet little is known about the underlying etiology. Erythropoietin (EPO) is renally produced in response to hypoxic and inflammatory conditions. Changes in serum EPO have been demonstrated in inf ... Full text Link to item Cite

Success rates with preimplantation genetic testing for aneuploidy in good prognosis patients are dependent on age.

Journal Article Fertil Steril · March 2025 OBJECTIVE: To evaluate cumulative live birth after preimplantation genetic testing for aneuploidy (PGT-A) with next generation sequencing (NGS) compared with morphology alone among patients aged 21-40 years undergoing single blastocyst transfer. DESIGN: Re ... Full text Link to item Cite

Transcutaneous Electric Nerve Stimulation for Analgesia During Outpatient Endometrial Biopsy: A Randomized Controlled Trial.

Journal Article Obstet Gynecol · January 1, 2025 OBJECTIVE: To evaluate whether transcutaneous electric nerve stimulation (TENS) decreases pain at the time of outpatient endometrial biopsy. METHODS: We conducted a randomized, double-blind trial of active TENS compared with placebo TENS at the time of end ... Full text Link to item Cite

Maternal morbidity in postpartum severe preeclampsia by obstetric delivery volume.

Conference Am J Obstet Gynecol MFM · November 2024 BACKGROUND: Pre-eclampsia is a leading cause of maternal morbidity and mortality in the United States. Emerging data suggests that postpartum pre-eclampsia may be associated with a higher incidence of maternal morbidity compared to hypertensive disorders o ... Full text Link to item Cite

Maternal morbidity in postpartum severe preeclampsia by obstetric delivery volume

Journal Article American Journal of Obstetrics & Gynecology MFM · November 2024 Full text Cite

Migraine May Represent an Independent Risk Factor for Retinal Stroke: A Population-Based Cohort Study.

Journal Article Clin Neurol Neurosurg · November 2024 INTRODUCTION: Migraine is an established risk factor for cerebral ischemic stroke, with an especially robust association in patients with migraine with aura. However, it is not known if migraine is a risk factor for retinal stroke (central or branch retina ... Full text Link to item Cite

Depression following small vessel stroke is common and more prevalent in women.

Journal Article J Stroke Cerebrovasc Dis · May 2024 OBJECTIVES: We sought to examine the frequency of depression after small vessel-type stroke (SVS) and associated risk factors. MATERIALS AND METHODS: We conducted a retrospective analysis of a prospective cohort of patients enrolled in the American Stroke ... Full text Open Access Link to item Cite

Obstetric Racial Disparities in the Era of the ARRIVE (A Randomized Trial of Induction Versus Expectant Management) Trial and the Coronavirus Disease 2019 (COVID-19) Pandemic.

Journal Article Obstet Gynecol · May 1, 2024 OBJECTIVE: To evaluate the influence of the ARRIVE (A Randomized Trial of Induction Versus Expectant Management) trial and the coronavirus disease 2019 (COVID-19) pandemic on racial and ethnic differences in labor induction, pregnancy-associated hypertensi ... Full text Link to item Cite

Cryocompression to Reduce Peripheral Neuropathy in Gynecologic Cancer: A Randomized Controlled Trial.

Journal Article Obstet Gynecol · December 1, 2023 OBJECTIVE: To investigate the efficacy of cryocompression therapy to prevent chemotherapy-induced peripheral neuropathy. METHODS: This single-institution, randomized, self-controlled trial of cryocompression enrolled gynecologic cancer patients planned for ... Full text Link to item Cite

Conjugation of HIV-1 envelope to hepatitis B surface antigen alters vaccine responses in rhesus macaques.

Journal Article NPJ Vaccines · November 24, 2023 An effective HIV-1 vaccine remains a critical unmet need for ending the AIDS epidemic. Vaccine trials conducted to date have suggested the need to increase the durability and functionality of vaccine-elicited antibodies to improve efficacy. We hypothesized ... Full text Open Access Link to item Cite

Validation of a sonographic checklist for the detection of histologic placenta accreta spectrum.

Journal Article Am J Obstet Gynecol MFM · August 2023 BACKGROUND: To standardize research terminology and to reduce unanticipated placenta accreta spectrum, the European Working Group for Abnormally Invasive Placenta developed a consensus checklist for reporting suspected placenta accreta spectrum observed du ... Full text Link to item Cite

Association Between Hospital-Documented Atrial Fibrillation and Central Retinal Artery Occlusion.

Journal Article Stroke · April 2023 BACKGROUND: Carotid stenosis is thought to be the primary risk factor for central retinal artery occlusion (CRAO); however, it is not known whether atrial fibrillation (AF)-a cardiac arrhythmia that underlies over 25% of cerebral ischemic strokes-predispos ... Full text Link to item Cite

Direct-to-consumer fertility testing: utilization and perceived utility among fertility patients and reproductive endocrinologists.

Journal Article Reprod Biomed Online · March 2023 RESEARCH QUESTION: What is the utilization of direct-to-consumer fertility tests (DTCFT) among fertility patients? How does the perceived utility of DTCFT differ between patients and reproductive endocrinologists (REI)? DESIGN: Infertility patients visitin ... Full text Link to item Cite

Suitability of Automated Writing Measures for Clinical Trial Outcome in Writer's Cramp.

Journal Article Mov Disord · January 2023 BACKGROUND: Writer's cramp (WC) dystonia is a rare disease that causes abnormal postures during the writing task. Successful research studies for WC and other forms of dystonia are contingent on identifying sensitive and specific measures that relate to th ... Full text Open Access Link to item Cite

Elevated Urinary Rab10 Phosphorylation in Idiopathic Parkinson Disease.

Journal Article Movement disorders : official journal of the Movement Disorder Society · July 2022 BackgroundPathogenic leucine-rich repeat kinase 2 LRRK2 mutations may increase LRRK2 kinase activity and Rab substrate phosphorylation. Genetic association studies link variation in LRRK2 to idiopathic Parkinson disease (iPD) risk.Objectives Full text Cite