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Shannon L Dahl

Adjunct Assistant Professor in the Department of Surgery
Surgery, Surgical Sciences

Selected Publications


Bioengineered human acellular vessels recellularize and evolve into living blood vessels after human implantation.

Journal Article Sci Transl Med · March 27, 2019 Traditional vascular grafts constructed from synthetic polymers or cadaveric human or animal tissues support the clinical need for readily available blood vessels, but often come with associated risks. Histopathological evaluation of these materials has sh ... Full text Link to item Cite

Clinical Outcomes of Arteriovenous Access in Incident Hemodialysis Patients with Medicare Coverage, 2012-2014.

Journal Article Am J Nephrol · 2019 BACKGROUND: Chronic hemodialysis requires a mode of vascular access through an arteriovenous fistula (AVF), a prosthetic arteriovenous graft (AVG), or a central venous catheter (CVC). AVF is recommended over AVG or CVC due to increased patency and decrease ... Full text Link to item Cite

Erratum: Bioengineered human acellular vessels recellularize and evolve into living blood vessels after human implantation (Science Translational Medicine DOI: 10.1126/scitranslmed.aau6934)

Journal Article Science Translational Medicine · January 1, 2019 In the Research Article "Bioengineered human acellular vessels recellularize and evolve into living blood vessels after human implantation," the reference value for suture strength of HAVs was reported incorrectly within the Results section. The PDF and HT ... Full text Cite

Engineering Human Acellular Vessels for Dialysis Access and Vascular Repair

Conference Journal of the American College of Surgeons · October 2018 Full text Cite

Susceptibility of ePTFE vascular grafts and bioengineered human acellular vessels to infection.

Journal Article J Surg Res · January 2018 BACKGROUND: Synthetic expanded polytetrafluorethylene (ePTFE) grafts are routinely used for vascular repair and reconstruction but prone to sustained bacterial infections. Investigational bioengineered human acellular vessels (HAVs) have shown clinical suc ... Full text Link to item Cite

Arteriovenous Fistulae for Haemodialysis: A Systematic Review and Meta-analysis of Efficacy and Safety Outcomes.

Journal Article Eur J Vasc Endovasc Surg · October 2017 BACKGROUND: Arteriovenous fistulae are the currently recommended gold standard vascular access modality for haemodialysis because of their prolonged patency, improved durability, and low risk of infection for those that mature. However, notable disadvantag ... Full text Link to item Cite

An early study on the mechanisms that allow tissue-engineered vascular grafts to resist intimal hyperplasia.

Journal Article J Cardiovasc Transl Res · October 2011 Intimal hyperplasia is one of the prominent failure mechanisms for arteriovenous fistulas and arteriovenous access grafts. Human tissue-engineered vascular grafts (TEVGs) were implanted as arteriovenous grafts in a novel baboon model. Ultrasound was used t ... Full text Link to item Cite

Readily available tissue-engineered vascular grafts.

Journal Article Sci Transl Med · February 2, 2011 Autologous or synthetic vascular grafts are used routinely for providing access in hemodialysis or for arterial bypass in patients with cardiovascular disease. However, some patients either lack suitable autologous tissue or cannot receive synthetic grafts ... Full text Link to item Cite

A microstructurally motivated model of the mechanical behavior of tissue engineered blood vessels.

Journal Article Ann Biomed Eng · November 2008 Mechanical models have potential to guide the development and use of engineered blood vessels as well as other engineered tissues. This paper presents a microstructurally motivated, pseudoelastic, mechanical model of the biaxial mechanics of engineered ves ... Full text Link to item Cite

An ultrastructural analysis of collagen in tissue engineered arteries.

Journal Article Ann Biomed Eng · October 2007 Collagen is the structural molecule that is most correlated with strength in blood vessels. In this study, we compared the properties of collagen in engineered and native blood vessels. Transmission electron microscopy (TEM) was used to image sections of e ... Full text Link to item Cite

Mechanical properties and compositions of tissue engineered and native arteries.

Journal Article Ann Biomed Eng · March 2007 With the goal of mimicking the mechanical properties of a given native tissue, tissue engineers seek to culture replacement tissues with compositions similar to those of native tissues. In this report, differences between the mechanical properties of engin ... Full text Link to item Cite

Feasibility of vitrification as a storage method for tissue-engineered blood vessels.

Journal Article Tissue Eng · February 2006 It is well established that, in multicellular systems, conventional cryopreservation results in damaging ice formation, both in the cells and in the surrounding extracellular matrix. As an alternative to conventional cryopreservation, we performed a feasib ... Full text Link to item Cite

Effects of Copper and Cross-Linking on the Extracellular Matrix of Tissue-Engineered Arteries.

Journal Article Cell Transplant · July 2005 In many cases, the mechanical strengths of tissue-engineered arteries do not match the mechanical strengths of native arteries. Ultimate arterial strength is primarily dictated by collagen in the extracellular matrix, but collagen in engineered arteries is ... Full text Link to item Cite

Blood vessels engineered from human cells.

Journal Article Lancet · June 18, 2005 Tissue engineering has made considerable progress in the past decade, but advances have stopped short of clinical application for most tissues. We postulated that an obstacle in engineering human tissues is the limited replicative capacity of adult somatic ... Full text Link to item Cite

Effects of copper and cross-linking on the extracellular matrix of tissue-engineered arteries.

Journal Article Cell Transplant · 2005 In many cases, the mechanical strengths of tissue-engineered arteries do not match the mechanical strengths of native arteries. Ultimate arterial strength is primarily dictated by collagen in the extracellular matrix. but collagen in engineered arteries is ... Link to item Cite

Decellularized Native and Engineered Arterial Scaffolds for Transplantation.

Journal Article Cell Transplant · September 2003 More than 570,000 coronary artery bypass grafts are implanted each year, creating an important demand for small-diameter vascular grafts. For patients who lack adequate internal mammary artery or saphenous vein, tissue-engineered arteries may prove useful. ... Full text Link to item Cite

Decellularized native and engineered arterial scaffolds for transplantation.

Journal Article Cell Transplant · 2003 More than 570,000 coronary artery bypass grafts are implanted each year, creating an important demand for small-diameter vascular grafts. For patients who lack adequate internal mammary artery or saphenous vein, tissue-engineered arteries may prove useful. ... Link to item Cite