https://orcid.org/0000-0003-3957-061X
Overview
As Vice Chair for Translational Research in the Department of Pathology, I am involved in numerous translational cancer research projects that rely on the study of human biological samples. I am the director of the Duke BioRepository & Precision Pathology Center (Duke BRPC), a shared resource of the School of Medicine and the Duke Cancer Institute. I serve as the PI for the National Cancer Institute's Cooperative Human Tissue Network Southern Division (a five-year UM1 grant), which lives in the Duke BRPC. My own area of research interest is gastrointestinal tract metaplasias and their relationship to carcinogenesis, particularly in the upper GI tract.
Current Duke Appointments & Affiliations
Associate Professor of Pathology
·
2020 - Present
Pathology,
Clinical Science Departments
Associate Professor in Surgery
·
2020 - Present
Surgery, Surgical Sciences,
Surgery
Member of the Duke Cancer Institute
·
2017 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Scholarly Works
Inhibition of cyclin-dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation.
Journal article Mol Oncol · June 30, 2026 Cyclin-dependent kinase (CDK) 12 and its paralog, CDK13, phosphorylate RNA polymerase II, enabling transcriptional elongation. In solid tumors, CDK12 loss promotes progression by inducing replication-transcription conflict and fueling genomic instability. ... Full text Link to item CiteThe College of American Pathologists Biorepository Accreditation Program: Results from the First 10 Years.
Journal article Biopreserv Biobank · April 2026 INTRODUCTION: The College of American Pathologists (CAP) Biorepository Accreditation Program (BAP) was established in 2012 with the goal of providing standardized requirements that ensure high quality for procuring, processing, storing, distributing, and c ... Full text Link to item CiteAssociation between autoimmune thyroid disease and presence of CagA and gastric intestinal metaplasia among patients with H. pylori: a cross-sectional endoscopic study.
Journal article BMC Endocr Disord · February 4, 2026 BACKGROUND: Autoimmune thyroid disease (AITD), specifically Graves’ disease and Hashimoto’s thyroiditis, has been seen to co-occur with Helicobacter pylori (H. pylori) infection. Some evidence suggests that the link is particularly strong with the H. pylor ... Full text Link to item CiteRecent Grants
Project GENIE Steering Committee Resolution Part III
ResearchPrincipal Investigator · Awarded by American Association for Cancer Research · 2025 - 2031Cooperative Human Tissue Network Support through Duke's BioRepository & Precision Pathology Center
ResearchPrincipal Investigator · Awarded by National Cancer Institute · 2019 - 2029Therapeutic intervention to reverse gastric precancer
Clinical TrialCo Investigator · Awarded by Department of Defense · 2024 - 2028View All Grants
Education
Duke University ·
2000
M.D.
North Carolina State University ·
1996
B.S.