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Shannon Jones McCall

Associate Professor of Pathology
Pathology
Duke Box 3712, Room 309 Davison Bldg, Durham, NC 27710
Dept of Pathology Box 3712, Room 309 Davison Building, Durham, NC 27710

Overview


As Vice Chair for Translational Research in the Department of Pathology, I am involved in numerous translational cancer research projects that rely on the study of human biological samples.  I am the director of the Duke BioRepository & Precision Pathology Center (Duke BRPC), a shared resource of the School of Medicine and the Duke Cancer Institute.  I serve as the PI for the National Cancer Institute's Cooperative Human Tissue Network Southern Division (a five-year UM1 grant), which lives in the Duke BRPC.  My own area of research interest is gastrointestinal tract metaplasias and their relationship to carcinogenesis, particularly in the upper GI tract.

Current Appointments & Affiliations


Associate Professor of Pathology · 2020 - Present Pathology, Clinical Science Departments
Associate Professor in Surgery · 2020 - Present Surgery, Surgical Sciences, Surgery
Member of the Duke Cancer Institute · 2017 - Present Duke Cancer Institute, Institutes and Centers

In the News


Published July 31, 2017
X-ray diffraction spectra classify breast tissue
Published January 4, 2017
Medical Xpress: Study sheds light on esophageal cancer
Published December 21, 2016
New breast cancer therapy targets common genetic mutation

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Recent Publications


T-cells are significantly reduced in the luminal gastrointestinal tract of patients with "complete" 22q11.2 deletion syndrome (DiGeorge syndrome): Utilization of chromogenic multiplex immunohistochemistry to define cellular populations.

Journal Article Ann Diagn Pathol · February 2025 Patients with 22q11.2 deletion syndrome or DiGeorge syndrome commonly report gastrointestinal symptoms in addition to more widely understood cardiac and immunodeficiency abnormalities. However, the morphologic features of gastrointestinal tract pathology i ... Full text Link to item Cite

Genetic ancestry concordant RNA splicing in prostate cancer involves oncogenic genes and associates with recurrence.

Journal Article NPJ Precis Oncol · January 29, 2025 Black men suffer disproportionately from prostate cancer (PCa) compared to men of other races and ethnicities. Comparing the molecular landscape of PCa among Black and White patients has the potential to identify targets for development of new precision me ... Full text Link to item Cite

Experts Speak Forum: Implementation of the FAIR Principles in Biobanking Needs Fair Incentives.

Journal Article Biopreserv Biobank · December 2024 While the FAIR (Findable, Accessible, Interoperable, and Reusable) principles are primarily concerned with data, samples can also be considered a distinct category of data. In light of these considerations, the FAIR principles represent a major challenge f ... Full text Link to item Cite
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Recent Grants


Cooperative Human Tissue Network Support through Duke's BioRepository & Precision Pathology Center

ResearchPrincipal Investigator · Awarded by National Cancer Institute · 2019 - 2029

Therapeutic intervention to reverse gastric precancer

Clinical TrialCo Investigator · Awarded by Department of Defense · 2024 - 2028

IMAGINE: Intestinal Metaplasia And Gastritis INtErception Study

ResearchPathologist · Awarded by National Institutes of Health · 2024 - 2028

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Education, Training & Certifications


Duke University · 2000 M.D.
North Carolina State University · 1996 B.S.