Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Pediatric Nephrology Fellowship, Pediatrics, University of Virginia 1992 - 1995
  • Pediatric Residency, Pediatrics, North Carolina Baptist Hospital 1990 - 1992
  • M.B.B.S., Kasturba Medical College (Manipal) 1982
• 

  Previous Appointments & Affiliations

  • Professor of Pediatrics, Pediatrics, Nephrology, Pediatrics 2017 - 2020
  • Associate Professor of Pediatrics, Pediatrics, Nephrology, Pediatrics 2009 - 2017
  • Instructor, Temporary in the Department of Pediatrics, Pediatrics, Nephrology, Pediatrics 2009
• Research
• 

  Selected Grants

  • Single arm Study of ALXN1210 in Complement Inhibitor Treatment-Naive Adult and Adolescent Patients with Atypical Hemolytic Uremic Syndrome (aHUS) awarded by Alexion Pharmaceuticals, Inc. 2017 - 2022
  • A PHASE 3, OPEN-LABEL, MULTICENTER STUDY OF ALXN1210 IN CHILDREN AND ADOLESCENTS WITH ATYPICAL HEMOLYTIC-UREMIC SYNDROME (aHUS) awarded by Alexion Pharmaceuticals, Inc. 2017 - 2020
  • Vifor PA21 Phaslyra awarded by Vifor Fresenius Medical Care Renal Pharma 2016 - 2019
  • An observational, non-interventional, multi-center, multi-national study of patients with Atypical Hemolytic-Uremic Syndrome (aHUS Registry) awarded by Alexion Pharmaceuticals, Inc. 2013 - 2018
• 

  External Relationships

  • National kidney foundation, North Carolina Chapter
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Barbour, T., M. Scully, G. Ariceta, S. Cataland, K. Garlo, N. Heyne, Y. Luque, et al. “Long-Term Efficacy and Safety of the Long-Acting Complement C5 Inhibitor Ravulizumab for the Treatment of Atypical Hemolytic Uremic Syndrome in Adults.” Kidney International Reports 6, no. 6 (June 1, 2021): 1603–13. https://doi.org/10.1016/j.ekir.2021.03.884.
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    • Rondeau, Eric, Marie Scully, Gema Ariceta, Tom Barbour, Spero Cataland, Nils Heyne, Yoshitaka Miyakawa, et al. “Corrigendum to "Rondeau E, Scully M, Ariceta G, Barbour T, Cataland S, Heyne N, Miyakawa Y, Ortiz S, Swenson E, Vallee M, Yoon S-S, Kavanagh D and Haller H; on behalf of the 311 Study Group. The long-acting C5 inhibitor, Ravulizumab, is effective and safe in adult patients with atypical hemolytic uremic syndrome naïve to complement inhibitor treatment." Kidney Int. 2020;97:1287-1296.” Kidney Int 99, no. 5 (May 2021): 1244. https://doi.org/10.1016/j.kint.2021.03.008.
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    • Rondeau, Eric, Marie Scully, Gema Ariceta, Tom Barbour, Spero Cataland, Nils Heyne, Yoshitaka Miyakawa, et al. “Erratum to "Rondeau E, Scully M, Ariceta G, Barbour T, Cataland S, Heyne N, Miyakawa Y, Ortiz S, Swenson E, Vallee M, Yoon S-S, Kavanagh D, Haller H; on behalf of the 311 Study Group. The long-acting C5 inhibitor, Ravulizumab, is effective and safe in adult patients with atypical hemolytic uremic syndrome naïve to complement inhibitor treatment" Kidney Int. 2020;97:1287-1296.” Kidney Int 98, no. 6 (December 2020): 1621. https://doi.org/10.1016/j.kint.2020.11.001.
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    • Blew, Kathryn H., Annabelle Chua, John Foreman, Rasheed Gbadegesin, Annette Jackson, Shashi Nagaraj, Rebecca Sadun, Del Wigfall, Allan D. Kirk, and Eileen T. Chambers. “Tailored use of belatacept in adolescent kidney transplantation.” Am J Transplant 20, no. 3 (March 2020): 884–88. https://doi.org/10.1111/ajt.15611.
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    • Del Dotto, Valentina, Farid Ullah, Ivano Di Meo, Pamela Magini, Mirjana Gusic, Alessandra Maresca, Leonardo Caporali, et al. “SSBP1 mutations cause mtDNA depletion underlying a complex optic atrophy disorder.” J Clin Invest 130, no. 1 (January 2, 2020): 108–25. https://doi.org/10.1172/JCI128514.
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    • Pelletier, Jonathan H., Karan R. Kumar, Rachel Engen, Adam Bensimhon, Jennifer D. Varner, Michelle N. Rheault, Tarak Srivastava, et al. “Correction to: Recurrence of nephrotic syndrome following kidney transplantation is associated with initial native kidney biopsy findings : A Midwest Pediatric Nephrology Consortium (MWPNC) study.” Pediatr Nephrol 34, no. 3 (March 2019): 539. https://doi.org/10.1007/s00467-018-4103-3.
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    • Freischlag, Kyle W., Vivian Chen, Shashi K. Nagaraj, Annabelle N. Chua, Dongfeng Chen, Delbert R. Wigfall, John W. Foreman, Rasheed Gbadegesin, Deepak Vikraman, and Eileen T. Chambers. “Psychosocial Assessment of Candidates for Transplantation (PACT) Score Identifies High Risk Patients in Pediatric Renal Transplantation.” Front Pediatr 7 (2019): 102. https://doi.org/10.3389/fped.2019.00102.
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    • Pelletier, Jonathan H., Karan R. Kumar, Rachel Engen, Adam Bensimhon, Jennifer D. Varner, Michelle N. Rheault, Tarak Srivastava, et al. “Recurrence of nephrotic syndrome following kidney transplantation is associated with initial native kidney biopsy findings.” Pediatr Nephrol 33, no. 10 (October 2018): 1773–80. https://doi.org/10.1007/s00467-018-3994-3.
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    • Pena, Loren D. M., Yong-Hui Jiang, Kelly Schoch, Rebecca C. Spillmann, Nicole Walley, Nicholas Stong, Sarah Rapisardo Horn, et al. “Looking beyond the exome: a phenotype-first approach to molecular diagnostic resolution in rare and undiagnosed diseases.” Genet Med 20, no. 4 (April 2018): 464–69. https://doi.org/10.1038/gim.2017.128.
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    • Pelletier, Jonathan H., Shashi Nagaraj, Rasheed Gbadegesin, Delbert Wigfall, Kathleen A. McGann, and John Foreman. “Neutropenic enterocolitis (typhlitis) in a pediatric renal transplant patient. A case report and review of the literature.” Pediatr Transplant 21, no. 6 (September 2017). https://doi.org/10.1111/petr.13022.
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    • Elahi, Shan, Alison Homstad, Himani Vaidya, Jennifer Stout, Gentzon Hall, Guanghong Wu, Peter Conlon, et al. “Rare variants in tenascin genes in a cohort of children with primary vesicoureteric reflux.” Pediatr Nephrol 31, no. 2 (February 2016): 247–53. https://doi.org/10.1007/s00467-015-3203-6.
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    • Phelan, Paul J., Gentzon Hall, Delbert Wigfall, John Foreman, Shashi Nagaraj, Andrew F. Malone, Michelle P. Winn, David N. Howell, and Rasheed Gbadegesin. “Variability in phenotype induced by the podocin variant R229Q plus a single pathogenic mutation.” Clin Kidney J 8, no. 5 (October 2015): 538–42. https://doi.org/10.1093/ckj/sfv063.
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    • Gbadegesin, Rasheed A., Adebowale Adeyemo, Nicholas J. A. Webb, Larry A. Greenbaum, Asiri Abeyagunawardena, Shenal Thalgahagoda, Arundhati Kale, et al. “HLA-DQA1 and PLCG2 Are Candidate Risk Loci for Childhood-Onset Steroid-Sensitive Nephrotic Syndrome.” J Am Soc Nephrol 26, no. 7 (July 2015): 1701–10. https://doi.org/10.1681/ASN.2014030247.
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    • Wang, Hsin-Hsiao S., Rasheed A. Gbadegesin, John W. Foreman, Shashi K. Nagaraj, Delbert R. Wigfall, John S. Wiener, and Jonathan C. Routh. “Efficacy of antibiotic prophylaxis in children with vesicoureteral reflux: systematic review and meta-analysis.” J Urol 193, no. 3 (March 2015): 963–69. https://doi.org/10.1016/j.juro.2014.08.112.
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    • McNamara, Erin R., Jennifer Sullivan, Shashi K. Nagaraj, John S. Wiener, and Priya S. Kishnani. “Neurogenic bladder dysfunction presenting as urinary retention in neuronopathic Gaucher disease.” Jimd Rep 15 (2015): 67–70. https://doi.org/10.1007/8904_2014_299.
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    • Kobayashi, Daisuke, Shashi K. Nagaraj, Jen-Jar Lin, and Daniel G. Bichet. “A de novo novel missense mutation in AVPR2 with severe nephrogenic diabetes insipidus.” Ndt Plus 3, no. 6 (December 2010): 542–44. https://doi.org/10.1093/ndtplus/sfq158.
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    • MacHardy, Nathaniel, Paul V. Miles, Susan F. Massengill, William E. Smoyer, John D. Mahan, Larry Greenbaum, Sara Massie, et al. “Management patterns of childhood-onset nephrotic syndrome.” Pediatr Nephrol 24, no. 11 (November 2009): 2193–2201. https://doi.org/10.1007/s00467-009-1282-y.
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    • Freedman, B. I., S. K. Nagaraj, J. -. J. Lin, M. D. Gautreaux, D. W. Bowden, S. S. Iskandar, R. J. Stratta, et al. “Potential donor-recipient MYH9 genotype interactions in posttransplant nephrotic syndrome after pediatric kidney transplantation.” Am J Transplant 9, no. 10 (October 2009): 2435–40. https://doi.org/10.1111/j.1600-6143.2009.02806.x.
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    • Gipson, Debbie S., Susan F. Massengill, Lynne Yao, Shashi Nagaraj, William E. Smoyer, John D. Mahan, Delbert Wigfall, et al. “Management of childhood onset nephrotic syndrome.” Pediatrics 124, no. 2 (August 2009): 747–57. https://doi.org/10.1542/peds.2008-1559.
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    • Trachtman, Howard, James W. Hainer, Jennifer Sugg, Renli Teng, Jonathan M. Sorof, Jerilynn Radcliffe, and Jerilynn Candesartan in Children with Hypertension (CINCH) Investigators. “Efficacy, safety, and pharmacokinetics of candesartan cilexetil in hypertensive children aged 6 to 17 years.” J Clin Hypertens (Greenwich) 10, no. 10 (October 2008): 743–50. https://doi.org/10.1111/j.1751-7176.2008.00022.x.
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    • Ferris, Maria, Uptal D. Patel, Susan Massengill, Debbie Gipson, William Conley, J Bradley Layton, Shashi Nagaraj, and William Primack. “Pediatric chronic kidney disease in North Carolina.” N C Med J 69, no. 3 (2008): 208–14.
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    • Zlotkin, David, Amanda Hudgins, Amy Thompson, Christine E. Waasdorp, James R. Kerrigan, Shashi K. Nagaraj, and Robert P. Schwartz. “Index of suspicion.” Pediatr Rev 28, no. 4 (April 2007): 139–45. https://doi.org/10.1542/pir.28-4-139.
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    • Shetty, A. K., S. K. Nagaraj, W. B. Lorentz, and M. Bitzan. “Peritonitis due to Neisseria mucosa in an adolescent receiving peritoneal dialysis.” Infection 33, no. 5–6 (October 2005): 390–92. https://doi.org/10.1007/s15010-005-5074-4.
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    • Piercy, K Todd, Jonathan C. Hundley, Jeanette M. Stafford, Timothy E. Craven, Shashi K. Nagaraj, Richard H. Dean, and Kimberley J. Hansen. “Renovascular disease in children and adolescents.” J Vasc Surg 41, no. 6 (June 2005): 973–82. https://doi.org/10.1016/j.jvs.2005.03.007.
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    • Super, Elizabeth A., Kathi J. Kemper, Charles Woods, and Shashi Nagaraj. “Cranberry use among pediatric nephrology patients.” Ambul Pediatr 5, no. 4 (2005): 249–52. https://doi.org/10.1367/A04-185R1.1.
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    • Stratta, Robert J., Michael S. Rohr, Patricia L. Adams, Aimee K. Sundberg, Erica L. Hartmann, Greg Armstrong, Teresa K. Anderson, et al. “Kidney and pancreas transplantation at Wake Forest University Baptist Medical Center.” Clin Transpl, 2003, 229–45.
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    • Hoffmann, Ingrid M., Bruce K. Rubin, Samy S. Iskandar, Michael S. Schechter, Shashi K. Nagaraj, and Martin M. Bitzan. “Acute renal failure in cystic fibrosis: association with inhaled tobramycin therapy.” Pediatr Pulmonol 34, no. 5 (November 2002): 375–77. https://doi.org/10.1002/ppul.10185.
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    • Ray, Patricio, David Acheson, Ramona Chitrakar, Avital Cnaan, Kathleen Gibbs, Gladys H. Hirschman, Erica Christen, and Howard Trachtman. “Basic fibroblast growth factor among children with diarrhea-associated hemolytic uremic syndrome.” J Am Soc Nephrol 13, no. 3 (March 2002): 699–707. https://doi.org/10.1681/ASN.V133699.
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    • Greenbaum, L. A., A. M. Simckes, D. McKenney, G. Kainer, S. K. Nagaraj, H. Trachtman, and U. S. Alon. “Pediatric biopsy of a single native kidney.” Pediatr Nephrol 15, no. 1–2 (November 2000): 66–69. https://doi.org/10.1007/s004670000417.
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    • Bitzan, M. M., S. K. Nagaraj, J. W. Georgitis, L. B. Givner, W. B. Lorentz, and S. S. Iskandar. “Staphylococcus aureus pneumonia, hyponatremia, hypertension, proteinuria, and hematuria in a 14-year-old boy.” Am J Kidney Dis 35, no. 2 (February 2000): 354–59. https://doi.org/10.1016/s0272-6386(00)70351-9.
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    • Hilgers, K. F., S. K. Nagaraj, E. A. Karginova, I. G. Kazakova, R. L. Chevalier, R. M. Carey, E. S. Pentz, and R. A. Gomez. “Molecular cloning of KS, a novel rat gene expressed exclusively in the kidney.” Kidney Int 54, no. 5 (November 1998): 1444–54. https://doi.org/10.1046/j.1523-1755.1998.00143.x.
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    • Robson, W. L., V. Shashi, S. Nagaraj, and J. P. Nørgaard. “Water intoxication in a patient with the Prader-Willi syndrome treated with desmopressin for nocturnal enuresis.” J Urol 157, no. 2 (February 1997): 646–47.
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    • Givner, L. B., and S. K. Nagaraj. “Hyperimmune human IgG or recombinant human granulocyte-macrophage colony-stimulating factor as adjunctive therapy for group B streptococcal sepsis in newborn rats.” J Pediatr 122, no. 5 Pt 1 (May 1993): 774–79. https://doi.org/10.1016/s0022-3476(06)80025-9.
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  • Conference Papers

    • NAGARAJ, S. K., E. A. KARGINOVA, I. G. KAZAKOVA, R. M. CAREY, and R. A. GOMEZ. “A UNIQUE KIDNEY SPECIFIC GENE.” In Journal of the American Society of Nephrology, 6:804–804. WILLIAMS & WILKINS, 1995.
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