Scholars@Duke
Shengli Song

Shengli Song

Assistant Professor of Surgery
Surgery, Abdominal Transplant Surgery

Selected Publications

A novel immunoglobulin G- and immunoglobulin cleaving enzyme MG (IceMG), for antibody-mediated rejection.

Journal Article Am J Transplant · October 22, 2025 Antibody-mediated rejection remains a significant barrier to successful outcomes in both allotransplantation and xenotransplantation. In this study, we investigate the efficacy of a novel recombinant endopeptidase, IceMG, which simultaneously cleaves immun ... Full text Link to item Cite

A protective and broadly binding antibody class engages the influenza virus hemagglutinin head at its stem interface.

Journal Article mBio · June 11, 2025 UNLABELLED: Influenza infection and vaccination impart strain-specific immunity that protects against neither seasonal antigenic variants nor the next pandemic. However, antibodies directed to conserved sites can confer broad protection. Here, we identify ... Full text Link to item Cite

Fluorescence-barcoded cell lines stably expressing membrane-anchored influenza neuraminidases.

Journal Article Vaccine · May 22, 2025 The discovery of broadly protective antibodies to the influenza virus neuraminidase (NA) has raised interest in NA as a vaccine target. However, recombinant, solubilized tetrameric NA ectodomains are often challenging to express and isolate, hindering the ... Full text Link to item Cite

A protective and broadly binding antibody class engages the influenza virus hemagglutinin head at its stem interface.

Journal Article bioRxiv · July 1, 2024 Influenza infection and vaccination impart strain-specific immunity that protects against neither seasonal antigenic variants nor the next pandemic. However, antibodies directed to conserved sites can confer broad protection. Here we identify and character ... Full text Link to item Cite

Protective human antibodies against a conserved epitope in pre- and postfusion influenza hemagglutinin.

Journal Article Proc Natl Acad Sci U S A · January 2, 2024 Phylogenetically and antigenically distinct influenza A and B viruses (IAV and IBV) circulate in human populations, causing widespread morbidity. Antibodies (Abs) that bind epitopes conserved in both IAV and IBV hemagglutinins (HAs) could protect against d ... Full text Link to item Cite

Translation of therapeutic strategies to modulate B cell reponses from non-human primate models to human kidney transplantation.

Journal Article Front Transplant · 2023 Using novel drugs targeting lymphocyte costimulation, cytokines, antibody, complement, and plasma cells, we have developed strategies in a non-human primate model to modulate the B cell response to incompatible kidney transplants. After more than two decad ... Full text Link to item Cite

Recall of B cell memory depends on relative locations of prime and boost immunization.

Journal Article Sci Immunol · May 6, 2022 Immunization or microbial infection can establish long-term B cell memory not only systemically but also locally. Evidence has suggested that local B cell memory contributes to early local plasmacytic responses after secondary challenge. However, it is unc ... Full text Link to item Cite

A cell-based multiplex immunoassay platform using fluorescent protein-barcoded reporter cell lines.

Journal Article Commun Biol · November 25, 2021 Multiplex immunoassays with acellular antigens are well-established based on solid-phase platforms such as the Luminex® technology. Cell barcoding by amine-reactive fluorescent dyes enables analogous cell-based multiplex assays, but requires multiple label ... Full text Open Access Link to item Cite

Allo-Specific Humoral Responses: New Methods for Screening Donor-Specific Antibody and Characterization of HLA-Specific Memory B Cells.

Journal Article Front Immunol · 2021 Antibody-mediated allograft rejection (AMR) causes more kidney transplant failure than any other single cause. AMR is mediated by antibodies recognizing antigens expressed by the graft, and antibodies generated against major histocompatibility complex (MHC ... Full text Open Access Link to item Cite

Cross-Reactivity to Kynureninase Tolerizes B Cells That Express the HIV-1 Broadly Neutralizing Antibody 2F5.

Journal Article J Immunol · December 15, 2019 2F5 is an HIV-1 broadly neutralizing Ab that also binds the autoantigens kynureninase (KYNU) and anionic lipids. Generation of 2F5-like Abs is proscribed by immune tolerance, but it is unclear which autospecificity is responsible. We sampled the BCR repert ... Full text Link to item Cite

Antibodies to a Conserved Influenza Head Interface Epitope Protect by an IgG Subtype-Dependent Mechanism.

Journal Article Cell · May 16, 2019 Vaccines to generate durable humoral immunity against antigenically evolving pathogens such as the influenza virus must elicit antibodies that recognize conserved epitopes. Analysis of single memory B cells from immunized human donors has led us to charact ... Full text Link to item Cite