Shelby Addison Neal
Assistant Professor of Obstetrics and Gynecology
Current Research Interests
Preimplantation genetic testing for aneuploidy
Three-dimensional ultrasound imaging
Current Appointments & Affiliations
- Assistant Professor of Obstetrics and Gynecology, Obstetrics and Gynecology, Reproductive Endocrinology & Fertility, Obstetrics and Gynecology 2021
Contact Information
- 5601 Arringdon Park Drive, Suite 210, Morrisville, NC 27560
- 5601 Arringdon Park Drive, Suite 210, Morrisville, NC 27560
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shelby.neal@duke.edu
(919) 572-4673
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Duke Fertility Center
- Background
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Education, Training, & Certifications
- Board Certified, Reproductive Endocrinology And Infertility Subspecialty Certification, American Board of Obstetrics and Gynecology 2021 - 2023
- Board Certified, Obstetrics And Gynecology, American Board of Obstetrics and Gynecology 2017 - 2023
- Reproductive Endocrinology & Infertility Fellowship, Obstetrics And Gynecology, Thomas Jefferson University, Sidney Kimmel Medical College 2016 - 2019
- Residency, Obstetrics And Gynecology, Medical University of South Carolina 2011 - 2015
- M.D., University of North Carolina, Chapel Hill, School of Medicine 2011
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Medical Licensure
- 2019-01251. North Carolina. 2019
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Leadership & Clinical Positions at Duke
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Director of Assisted Reproductive Technology, Duke Fertility Center, 2021-present
Co-Director of Third Party Reproduction, Duke Fertility Center, 2021-present
Medical Director of Duke Fertility Center, 2023-present
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Director of Assisted Reproductive Technology, Duke Fertility Center, 2021-present
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Academic Positions Outside Duke
- Assistant Professor, Department of Obstetrics & Gynecology, Reproductive Medicine, Wake Forest Baptist Health. 2019 - 2021
- Recognition
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In the News
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JAN 10, 2023 Duke Health News -
JUL 7, 2022 Duke Health News
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Awards & Honors
- American Society for Reproductive Medicine Corporate Member Council In-Training Travel Award. American Society for Reproductive Medicine . 2019
- American Society for Reproductive Medicine Corporate Member Council In-Training Travel Award. American Society for Reproductive Medicine . 2018
- Pacific Coast Reproductive Society Scholarship Award. Pacific Coast Reproductive Society. 2018
- Coastal Fertility Award. Coastal Fertility. 2015
- American Society for Reproductive Medicine Resident Reporter. American Society for Reproductive Medicine. 2014
- Medical University of South Carolina Resident Research Award. Medical University of South Carolina. 2014
- American Society for Reproductive Medicine Resident Reporter. American Society for Reproductive Medicine. 2013
- Expertise
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Subject Headings
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Kim, Julia, George Patounakis, Caroline Juneau, Scott Morin, Shelby Neal, Paul Bergh, Emre Seli, and Richard Scott. “The Appraisal of Body Content (ABC) trial: Increased male or female adiposity does not significantly impact in vitro fertilization laboratory or clinical outcomes.” Fertil Steril 116, no. 2 (August 2021): 444–52. https://doi.org/10.1016/j.fertnstert.2020.12.037.Full Text Link to Item
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Kim, Julia, Caroline Juneau, George Patounakis, Scott Morin, Shelby Neal, Emre Seli, and Richard Scott. “The appraisal of body content (ABC) trial: obesity does not significantly impact gamete production in infertile men and women.” J Assist Reprod Genet 37, no. 11 (November 2020): 2733–42. https://doi.org/10.1007/s10815-020-01930-3.Full Text Link to Item
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Klimczak, Amber M., Andres Reig, Shelby A. Neal, Emre Seli, and Richard T. Scott. “Interpretation of noninvasive prenatal testing results following in vitro fertilization and preimplantation genetic testing for aneuploidy.” Am J Obstet Gynecol Mfm 2, no. 4 (November 2020): 100232. https://doi.org/10.1016/j.ajogmf.2020.100232.Full Text Link to Item
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Neal, S., S. Morin, M. Werner, N. -. A. Gueye, P. Pirtea, G. Patounakis, R. Scott, and L. Goodman. “Three-dimensional ultrasound diagnosis of adenomyosis is not associated with adverse pregnancy outcome following single thawed euploid blastocyst transfer: prospective cohort study.” Ultrasound Obstet Gynecol 56, no. 4 (October 2020): 611–17. https://doi.org/10.1002/uog.22065.Full Text Link to Item
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Murugappan, G., J. G. Kim, J. D. Kort, B. M. Hanson, S. A. Neal, A. W. Tiegs, E. K. Osman, R. T. Scott, and R. B. Lathi. “Prognostic value of blastocyst grade after frozen euploid embryo transfer in patients with recurrent pregnancy loss.” F and S Reports 1, no. 2 (September 1, 2020): 113–18. https://doi.org/10.1016/j.xfre.2020.07.001.Full Text
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Osman, E. K., S. A. Neal, A. W. Tiegs, B. M. Hanson, J. G. Kim, J. M. Franasiak, and R. T. Scott. “Consistency in rates of diagnosis of embryonic mosaicism, segmental abnormalities, and “no call” results among experienced embryologists performing preimplantation genetic testing for aneuploidy.” F and S Reports 1, no. 2 (September 1, 2020): 119–24. https://doi.org/10.1016/j.xfre.2020.05.005.Full Text
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Morin, Scott J., Brent M. Hanson, Caroline R. Juneau, Shelby A. Neal, Jessica N. Landis, Richard T. Scott, and James M. Hotaling. “A comparison of the relative efficiency of ICSI and extended culture with epididymal sperm versus testicular sperm in patients with obstructive azoospermia.” Asian J Androl 22, no. 2 (2020): 222–26. https://doi.org/10.4103/aja.aja_58_19.Full Text Link to Item
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Neal, Shelby A., Scott J. Morin, Marie D. Werner, Ndeye-Aicha Gueye, Paul Pirtea, Richard T. Scott, and Linnea R. Goodman. “Three-dimensional ultrasound diagnosis of T-shaped uterus is associated with adverse pregnancy outcomes after embryo transfer.” Reprod Biomed Online 39, no. 5 (November 2019): 777–83. https://doi.org/10.1016/j.rbmo.2019.07.030.Full Text Link to Item
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Neal, Shelby A., L. Sun, C. Jalas, S. J. Morin, T. A. Molinaro, and R. T. Scott. “When next-generation sequencing-based preimplantation genetic testing for aneuploidy (PGT-A) yields an inconclusive report: diagnostic results and clinical outcomes after re biopsy.” J Assist Reprod Genet 36, no. 10 (October 2019): 2103–9. https://doi.org/10.1007/s10815-019-01550-6.Full Text Link to Item
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Neal, Shelby A., Scott J. Morin, Jason M. Franasiak, Linnea R. Goodman, Caroline R. Juneau, Eric J. Forman, Marie D. Werner, and Richard T. Scott. “Preimplantation genetic testing for aneuploidy is cost-effective, shortens treatment time, and reduces the risk of failed embryo transfer and clinical miscarriage.” Fertil Steril 110, no. 5 (October 2018): 896–904. https://doi.org/10.1016/j.fertnstert.2018.06.021.Full Text Link to Item
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Neal, Shelby A., and Marie D. Werner. “Quest for a less invasive approach to preimplantation genetic testing remains ongoing.” Fertil Steril 110, no. 5 (October 2018): 845–46. https://doi.org/10.1016/j.fertnstert.2018.06.038.Full Text Link to Item
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Juneau, Caroline R., Jason M. Franasiak, Linnea R. Goodman, Diego Marin, Katherine Scott, Scott J. Morin, Shelby A. Neal, Jeffrey E. Juneau, and Richard T. Scott. “Celiac disease is not more prevalent in patients undergoing in vitro fertilization and does not affect reproductive outcomes with or without treatment: a large prospective cohort study.” Fertil Steril 110, no. 3 (August 2018): 437–42. https://doi.org/10.1016/j.fertnstert.2018.03.030.Full Text Link to Item
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Morin, S. J., G. Patounakis, C. R. Juneau, S. A. Neal, R. T. Scott, and E. Seli. “Diminished ovarian reserve and poor response to stimulation in patients <38 years old: a quantitative but not qualitative reduction in performance.” Hum Reprod 33, no. 8 (August 1, 2018): 1489–98. https://doi.org/10.1093/humrep/dey238.Full Text Link to Item
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Neal, Shelby A., and Marie D. Werner. “The impact of contemporary preimplantation genetic screening and diagnosis on the detection of aneuploidy and inherited genetic diseases.” Birth Defects Res 110, no. 8 (May 1, 2018): 644–47. https://doi.org/10.1002/bdr2.1220.Full Text Link to Item
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Rashid, Tariq, Jennifer L. Young-Pierce, Elizabeth Garrett-Mayer, Whitney Graybill, Shelby Neal, and Laura S. Spruill. “CD8, FoxP3, and CD45RO+ Lymphocytic Infiltrates in Type I and Type II Endometrial Cancers in African American and European American Females.” Int J Gynecol Pathol 36, no. 6 (November 2017): 540–49. https://doi.org/10.1097/PGP.0000000000000359.Full Text Link to Item
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Neal, Shelby A., Jason M. Franasiak, Eric J. Forman, Marie D. Werner, Scott J. Morin, Xin Tao, Nathan R. Treff, and Richard T. Scott. “High relative deoxyribonucleic acid content of trophectoderm biopsy adversely affects pregnancy outcomes.” Fertil Steril 107, no. 3 (March 2017): 731-736.e1. https://doi.org/10.1016/j.fertnstert.2016.11.013.Full Text Link to Item
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Franasiak, Jason, Daniel Kaser, Linnea Goodman, George Patounakis, Caroline Juneau, Scott Morin, Shelby Neal, William Schlaff, and Richard Scott. “Characterization of reproductive endocrinology and infertility (REI) fellowship applicants: guiding our mentees toward success.” Fertil Res Pract 3 (2017): 18. https://doi.org/10.1186/s40738-017-0045-x.Full Text Link to Item
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Neal, Shelby A., Whitney S. Graybill, Elizabeth Garrett-Mayer, Misty L. McDowell, Virginia E. McLean, Catherine H. Watson, Jennifer Y. Pierce, Matthew F. Kohler, and William T. Creasman. “Lymphovascular space invasion in uterine corpus cancer: What is its prognostic significance in the absence of lymph node metastases?” Gynecol Oncol 142, no. 2 (August 2016): 278–82. https://doi.org/10.1016/j.ygyno.2016.05.037.Full Text Link to Item
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Treff, Nathan R., Katherine Thompson, Michael Rafizadeh, Michael Chow, Liza Morrison, Xin Tao, Heather Garnsey, et al. “SNP array-based analyses of unbalanced embryos as a reference to distinguish between balanced translocation carrier and normal blastocysts.” J Assist Reprod Genet 33, no. 8 (August 2016): 1115–19. https://doi.org/10.1007/s10815-016-0734-0.Full Text Link to Item
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Addison, Shelby, R Edward Coleman, Sheng Feng, Gary McDaniel, and Virginia Byers Kraus. “Whole-body bone scintigraphy provides a measure of the total-body burden of osteoarthritis for the purpose of systemic biomarker validation.” Arthritis Rheum 60, no. 11 (November 2009): 3366–73. https://doi.org/10.1002/art.24856.Full Text Link to Item
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Henrotin, Yves, Shelby Addison, Virginia Kraus, and Michelle Deberg. “Type II collagen markers in osteoarthritis: what do they indicate?” Curr Opin Rheumatol 19, no. 5 (September 2007): 444–50. https://doi.org/10.1097/BOR.0b013e32829fb3b5.Full Text Link to Item
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Book Sections
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Neal, S. A., J. M. Franasiak, and R. T. Scott. “Hematologic disease in implantation failure.” In Recurrent Implantation Failure: Etiologies and Clinical Management, 125–34, 2018. https://doi.org/10.1007/978-3-319-71967-2_8.Full Text
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- Teaching & Mentoring
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Teaching Activities
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Duke University School of Medicine Lectures
• Evaluation and Management of Infertility, May 2023
Duke Reproductive Endocrinology and Infertility Fellows’ Conference
• Recurrent Pregnancy Loss, April 2021
• Immunoassays, June 2021
• Evaluation of the Infertile Female, July 2021 & August 2022
• Introduction to Assisted Reproductive Technology, July 2021
• Ovulation Induction, August 2021 & September 2022
• Endocrinology of Pregnancy, November 2021 & October 2022
• Amenorrhea, January 2022 & January 2023
• Gamete and Embryo Donation, February 2022
• Gestational Carrier Screening, March 2022
• Complications of Oocyte Retrieval, April 2022
• Gametogenesis and Fertilization, July 2022
• Neuroendocrinology, February 2023
Duke Maternal Fetal Medicine Fellows’ Conference
• Congenital Adrenal Hyperplasia, August 2021
Wake Forest Obstetrics & Gynecology Resident Conference
• Amenorrhea, March 2020
• Mullerian Anomalies, March 2020
• Recurrent Pregnancy Loss, January 2021
Wake Forest Gynecologic Oncology Fellows’ Conference
• Fertility Preservation for Cancer Patients, November 2019
Wake Forest Obstetrics & Gynecology Medical Student Clerkship Lectures
• Abnormal Uterine Bleeding, July 2020, August 2020, October 2020, January 2021
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- Scholarly, Clinical, & Service Activities
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Presentations & Appearances
- Surrogacy in North Carolina: The Basics. Circle Surrogacy & Egg Donation. November 2022 2022
- Journey to Parenthood: Family Building for LGBTQ+ Couples. Duke University School of Nursing Spectrum. March 2022 2022
- First, do no harm: Minimizing the Risks of Assisted Reproductive Technology (ART). Obstetrics & Gynecology Grand Rounds. WakeMed. 2021 2021
- 30 Years of Reproductive Medicine. BestHealth Podcast. 2020 2020
- First, do no harm: Minimizing the Risks of Assisted Reproductive Technology (ART). Obstetrics & Gynecology Grand Rounds. Wake Forest Baptist Health. 2019 2019
- Genetic Testing: Is it Cost Effective?. This is Infertility Podcast. 2019 2019
- Low endometrial volume is not associated with diminished live birth following transfer of a single thawed euploid blastocyst. Annual meeting of the American Society for Reproductive Medicine. 2019 2019
- Pregnancy outcomes following hysteroscopic correction of T-shaped uteri. Annual meeting of the American Society for Reproductive Medicine. 2019 2019
- Three-dimensional ultrasound diagnosis of adenomyosis is not associated with diminished live birth following single thawed euploid blastocyst transfer: a prospective cohort study. . Annual meeting of the American Society for Reproductive Medicine. 2019 2019
- Ambiguous Genitalia. Resident CREOG Review Course. RMA New Jersey. 2018 - 2019 2018 - 2019
- Making the Most of Academic Preparation in Residency. Pathways in Reproductive Medicine. IVI / RMA. 2018 - 2019 2018 - 2019
- Only patients with obvious adenomyosis on three-dimensional ultrasound (3D US) are at increased risk of clinical loss following frozen embryo transfer. . Annual meeting of the American Society for Reproductive Medicine. 2018 2018
- Mullerian anomalies. Resident CREOG Review Course. RMA New Jersey. 2017 - 2019 2017 - 2019
- Polycystic Ovary Syndrome in Adolescents. Atlantic Health Pediatric Endocrinology Conference. 2017 2017
- Polycystic Ovary Syndrome. Resident CREOG Review Course. 2017 2017
- Single embryo transfer (SET) following comprehensive chromosome screening (CCS) is more cost-effective than unscreened sequential SET. . Annual meeting of the American Society for Reproductive Medicine. 2016 2016
- Ovulation Induction and Multiple Pregnancy. Obstetrics & Gynecology Grand Rounds. Medical University of South Carolina. 2013 2013
- Pregnancy Outcomes Following Bariatric Surgery. Maternal Fetal Medicine Conference. University of North Carolina. 2010 2010
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Outreach & Engaged Scholarship
- Ad hoc reviewer. American Journal of Obstetrics & Gynecology. 2020 2020
- Ad hoc reviewer. Journal of Assisted Reproduction and Genetics. 2019 2019
- Ad hoc reviewer. Reproductive BioMedicine Online. 2019 2019
- Ad hoc reviewer. Ultrasound in Obstetrics & Gynecology. 2019 2019
- Moderator, Early Pregnancy Loss oral abstract session. 74th annual meeting of the American Society for Reproductive Medicine. American Society for Reproductive Medicine. 2018 2018
- Ad hoc reviewer. Fertility & Sterility. 2016 2016
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Service to the Profession
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Service to Duke
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