Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., Oklahoma State University, Stillwater 1998
• 

  Previous Appointments & Affiliations

  • Associate Professor in Medicine, Medicine, Cardiology, Medicine 2015 - 2022
  • Associate Professor in Cell Biology, Cell Biology, Basic Science Departments 2015 - 2022
  • Assistant Professor in Cell Biology, Cell Biology, Basic Science Departments 2006 - 2015
  • Associate Professor in Medicine, Medicine, Cardiology, Medicine 2010 - 2015
  • Assistant Professor in Medicine, Medicine, Cardiology, Medicine 2005 - 2009
  • Assistant Research Professor in Medicine, Medicine, Cardiology, Medicine 2003 - 2005
• Expertise
• 

  Subject Headings

  • Muser Mentor
• Research
• 

  Selected Grants

  • Cell and Molecular Biology Training Program awarded by National Institutes of Health 2021 - 2026
  • Regulation of myocardial GPCRs by USP20 in normal and hypertrophied heart awarded by National Institutes of Health 2021 - 2025
  • Multidisciplinary Heart and Vascular Diseases awarded by National Institutes of Health 1975 - 2023
  • Regulation of Vascular Inflammatory Signaling by the Deubiquitinase USP20 awarded by National Institutes of Health 2019 - 2023
  • Establishing the molecular and cellular mechanisms of Lgr5 signaling for controlling cancer stem cell behavior awarded by National Institutes of Health 2017 - 2021
  • Effect of Lexicon compound LX9211 on Intracellular trafficking of the beta2AR awarded by Lexicon Pharmaceuticals 2020
  • Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
  • Effect of Lexicon compounds on Intrcellular trafficking of GPCRs. awarded by Lexicon Pharmaceuticals 2019 - 2020
  • Paracrine Control of Blood Pressure by Renal Intercalated Cells awarded by National Institutes of Health 2015 - 2020
  • Regulation of B-arrestin2's pro-atherogenic activity by the deubiquitinase USP20 awarded by National Institutes of Health 2014 - 2018
  • E3 Ligases and Deubiquitinases in GPCR Down Regulation awarded by National Institutes of Health 2005 - 2016
  • B-Arrestins and G Protein-Coupled Receptor Kinases in Cardiovascular Function awarded by National Institutes of Health 2002 - 2012
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Kaur, Suneet, Badr Sokrat, Megan E. Capozzi, Kimberley El, Yushi Bai, Aeva Jazic, Bridgette Han, et al. “The ubiquitination status of the glucagon receptor determines signal bias.” J Biol Chem 299, no. 5 (May 2023): 104690. https://doi.org/10.1016/j.jbc.2023.104690.
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    • Jean-Charles, Pierre-Yves, Vishwaesh Rajiv, Subhodeep Sarker, Sangoh Han, Yushi Bai, Ali Masoudi, and Sudha K. Shenoy. “A single phenylalanine residue in β-arrestin2 critically regulates its binding to G protein-coupled receptors.” J Biol Chem 298, no. 5 (May 2022): 101837. https://doi.org/10.1016/j.jbc.2022.101837.
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    • Kaur, Suneet, Yuqing Chen, and Sudha K. Shenoy. “Agonist-activated glucagon receptors are deubiquitinated at early endosomes by two distinct deubiquitinases to facilitate Rab4a-dependent recycling.” J Biol Chem 295, no. 49 (December 4, 2020): 16630–42. https://doi.org/10.1074/jbc.RA120.014532.
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    • Kaur, Suneet, Yuqing Chen, and Sudha K. Shenoy. “Agonist-activated glucagon receptors are deubiquitinated at early endosomes by two distinct deubiquitinases to facilitate Rab4a-dependent recycling.” J Biol Chem 295, no. 49 (December 4, 2020): 16630–42. https://doi.org/10.1074/jbc.RA120.014532.
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    • Nagi, Karim, Suneet Kaur, Yushi Bai, and Sudha K. Shenoy. “In-frame fusion of SUMO1 enhances βarrestin2's association with activated GPCRs as well as with nuclear pore complexes.” Cell Signal 75 (November 2020): 109759. https://doi.org/10.1016/j.cellsig.2020.109759.
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    • Ahn, Seungkirl, Sudha K. Shenoy, Louis M. Luttrell, and Robert J. Lefkowitz. “SnapShot: β-Arrestin Functions.” Cell 182, no. 5 (September 3, 2020): 1362-1362.e1. https://doi.org/10.1016/j.cell.2020.07.034.
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    • Toth, Krisztian, Karim Nagi, Lauren M. Slosky, Lauren Rochelle, Caroline Ray, Suneet Kaur, Sudha K. Shenoy, Marc G. Caron, and Larry S. Barak. “Encoding the β-Arrestin Trafficking Fate of Ghrelin Receptor GHSR1a: C-Tail-Independent Molecular Determinants in GPCRs.” Acs Pharmacol Transl Sci 2, no. 4 (August 9, 2019): 230–46. https://doi.org/10.1021/acsptsci.9b00018.
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    • Yu, Samuel Mon-Wei, Pierre-Yves Jean-Charles, Dennis M. Abraham, Suneet Kaur, Clarice Gareri, Lan Mao, Howard A. Rockman, and Sudha K. Shenoy. “The deubiquitinase ubiquitin-specific protease 20 is a positive modulator of myocardial β1-adrenergic receptor expression and signaling.” J Biol Chem 294, no. 7 (February 15, 2019): 2500–2518. https://doi.org/10.1074/jbc.RA118.004926.
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    • Nagi, Karim, and Sudha K. Shenoy. “Detection of β-Arrestin-Mediated G Protein-Coupled Receptor Ubiquitination Using BRET.” Methods Mol Biol 1957 (2019): 93–104. https://doi.org/10.1007/978-1-4939-9158-7_6.
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    • Zhang, Lisheng, Jiao-Hui Wu, Tai-Qin Huang, Igor Nepliouev, Leigh Brian, Zhushan Zhang, Virginia Wertman, et al. “Drebrin regulates angiotensin II-induced aortic remodelling.” Cardiovasc Res 114, no. 13 (November 1, 2018): 1806–15. https://doi.org/10.1093/cvr/cvy151.
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    • Jean-Charles, Pierre-Yves, Jiao-Hui Wu, Lisheng Zhang, Suneet Kaur, Igor Nepliouev, Jonathan A. Stiber, Leigh Brian, et al. “USP20 (Ubiquitin-Specific Protease 20) Inhibits TNF (Tumor Necrosis Factor)-Triggered Smooth Muscle Cell Inflammation and Attenuates Atherosclerosis.” Arterioscler Thromb Vasc Biol 38, no. 10 (October 2018): 2295–2305. https://doi.org/10.1161/ATVBAHA.118.311071.
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    • Luttrell, Louis M., Jialu Wang, Bianca Plouffe, Jeffrey S. Smith, Lama Yamani, Suneet Kaur, Pierre-Yves Jean-Charles, et al. “Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9.” Sci Signal 11, no. 549 (September 25, 2018). https://doi.org/10.1126/scisignal.aat7650.
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    • Freedman, Neil J., and Sudha K. Shenoy. “Regulation of inflammation by β-arrestins: Not just receptor tales.” Cell Signal 41 (January 2018): 41–45. https://doi.org/10.1016/j.cellsig.2017.02.008.
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    • Rajagopal, Sudarshan, and Sudha K. Shenoy. “GPCR desensitization: Acute and prolonged phases.” Cell Signal 41 (January 2018): 9–16. https://doi.org/10.1016/j.cellsig.2017.01.024.
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    • Zhang, Lisheng, Jiao-Hui Wu, James C. Otto, Susan B. Gurley, Elizabeth R. Hauser, Sudha K. Shenoy, Karim Nagi, et al. “Interleukin-9 mediates chronic kidney disease-dependent vein graft disease: a role for mast cells.” Cardiovasc Res 113, no. 13 (November 1, 2017): 1551–59. https://doi.org/10.1093/cvr/cvx177.
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    • Jean-Charles, Pierre-Yves, Samuel Mon-Wei Yu, Dennis Abraham, Reddy Peera Kommaddi, Lan Mao, Ryan T. Strachan, Zhu-Shan Zhang, et al. “Mdm2 regulates cardiac contractility by inhibiting GRK2-mediated desensitization of β-adrenergic receptor signaling.” Jci Insight 2, no. 17 (September 7, 2017). https://doi.org/10.1172/jci.insight.95998.
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    • Jean-Charles, Pierre-Yves, Suneet Kaur, and Sudha K. Shenoy. “G Protein-Coupled Receptor Signaling Through β-Arrestin-Dependent Mechanisms.” J Cardiovasc Pharmacol 70, no. 3 (September 2017): 142–58. https://doi.org/10.1097/FJC.0000000000000482.
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    • Jean-Charles, Pierre-Yves, Vishwaesh Rajiv, and Sudha K. Shenoy. “Cover Image, Volume 231, Number 10, October 2016.” J Cell Physiol 231, no. 10 (October 2016): i. https://doi.org/10.1002/jcp.25462.
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    • Jean-Charles, Pierre-Yves, Vishwaesh Rajiv, and Sudha K. Shenoy. “Ubiquitin-Related Roles of β-Arrestins in Endocytic Trafficking and Signal Transduction.” J Cell Physiol 231, no. 10 (October 2016): 2071–80. https://doi.org/10.1002/jcp.25317.
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    • Feger, Bryan J., J Will Thompson, Laura G. Dubois, Reddy P. Kommaddi, Matthew W. Foster, Rajashree Mishra, Sudha K. Shenoy, et al. “Microgravity induces proteomics changes involved in endoplasmic reticulum stress and mitochondrial protection.” Sci Rep 6 (September 27, 2016): 34091. https://doi.org/10.1038/srep34091.
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    • Jean-Charles, Pierre-Yves, Lisheng Zhang, Jiao-Hui Wu, Sang-Oh Han, Leigh Brian, Neil J. Freedman, and Sudha K. Shenoy. “Ubiquitin-specific Protease 20 Regulates the Reciprocal Functions of β-Arrestin2 in Toll-like Receptor 4-promoted Nuclear Factor κB (NFκB) Activation.” J Biol Chem 291, no. 14 (April 1, 2016): 7450–64. https://doi.org/10.1074/jbc.M115.687129.
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    • Shenoy, Sudha K. “PROGRESS IN MOLECULAR BIOLOGY AND TRANSLATIONAL SCIENCE Ubiquitination and Transmembrane Signaling.” Edited by S. K. Shenoy. Ubiquitination and Transmembrane Signaling 141 (January 1, 2016): XIII–XIV.
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    • Jean-Charles, P. -. Y., J. C. Snyder, and S. K. Shenoy. “Chapter One - Ubiquitination and Deubiquitination of G Protein-Coupled Receptors.” Prog Mol Biol Transl Sci 141 (2016): 1–55. https://doi.org/10.1016/bs.pmbts.2016.05.001.
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    • Jean-Charles, P. -. Y., N. J. Freedman, and S. K. Shenoy. “Chapter Nine - Cellular Roles of Beta-Arrestins as Substrates and Adaptors of Ubiquitination and Deubiquitination.” Prog Mol Biol Transl Sci 141 (2016): 339–69. https://doi.org/10.1016/bs.pmbts.2016.04.003.
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    • Shenoy, Sudha K. “Preface.” Prog Mol Biol Transl Sci 141 (2016): xiii–xiv. https://doi.org/10.1016/S1877-1173(16)30035-7.
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    • Kommaddi, Reddy Peera, Pierre-Yves Jean-Charles, and Sudha K. Shenoy. “Phosphorylation of the deubiquitinase USP20 by protein kinase A regulates post-endocytic trafficking of β2 adrenergic receptors to autophagosomes during physiological stress.” J Biol Chem 290, no. 14 (April 3, 2015): 8888–8903. https://doi.org/10.1074/jbc.M114.630541.
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    • Jean-Charles, Pierre-Yves, Lisheng Zhang, Sang-oh Han, Reddy Kommaddi, Jiao-Hui Wu, Neil Freedman, and Sudha Shenoy. “A novel anti-inflammatory signaling role for the deubiquitinase USP20 in vivo.” Faseb Journal 28, no. 1 (April 1, 2014).
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    • Shenoy, Sudha K. “Arrestin interaction with E3 ubiquitin ligases and deubiquitinases: functional and therapeutic implications.” Handb Exp Pharmacol 219 (2014): 187–203. https://doi.org/10.1007/978-3-642-41199-1_10.
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    • Shenoy, Sudha K. “Deubiquitinases and their emerging roles in β-arrestin-mediated signaling.” Methods Enzymol 535 (2014): 351–70. https://doi.org/10.1016/B978-0-12-397925-4.00020-1.
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    • Han, Sang-Oh, Reddy P. Kommaddi, and Sudha K. Shenoy. “Distinct roles for β-arrestin2 and arrestin-domain-containing proteins in β2 adrenergic receptor trafficking.” Embo Rep 14, no. 2 (February 2013): 164–71. https://doi.org/10.1038/embor.2012.187.
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    • Shenoy, S. “Regulation of β2Adrenergic Receptor Trafficking and Signaling by Ubiquitination and Deubiquitination,” January 1, 2013, 95–96. https://doi.org/10.1016/B978-0-12-800044-1.00082-9.
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    • Kommaddi, Reddy Peera, and Sudha K. Shenoy. “Arrestins and protein ubiquitination.” Prog Mol Biol Transl Sci 118 (2013): 175–204. https://doi.org/10.1016/B978-0-12-394440-5.00007-3.
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    • Han, Sang-oh, Kunhong Xiao, Jihee Kim, Jiao-Hui Wu, James W. Wisler, Nobuhiro Nakamura, Neil J. Freedman, and Sudha K. Shenoy. “MARCH2 promotes endocytosis and lysosomal sorting of carvedilol-bound β(2)-adrenergic receptors.” J Cell Biol 199, no. 5 (November 26, 2012): 817–30. https://doi.org/10.1083/jcb.201208192.
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    • Han, Sang-oh, Reddy Peera Kommaddi, Vidya Venkataramanan, and Sudha K. Shenoy. “beta-arrestin2 and ARRDC proteins have distinct roles in beta(2)AR trafficking and signaling.” Faseb Journal 26 (April 1, 2012).
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    • Wu, Jiao-Hui, Lisheng Zhang, Alexander C. Fanaroff, Xinjiang Cai, Krishn C. Sharma, Leigh Brian, Sabrina T. Exum, Sudha K. Shenoy, Karsten Peppel, and Neil J. Freedman. “G protein-coupled receptor kinase-5 attenuates atherosclerosis by regulating receptor tyrosine kinases and 7-transmembrane receptors.” Arterioscler Thromb Vasc Biol 32, no. 2 (February 2012): 308–16. https://doi.org/10.1161/ATVBAHA.111.239608.
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    • Shenoy, S. K., S. Han, Y. L. Zhao, M. R. Hara, T. Oliver, Y. Cao, and M. W. Dewhirst. “β-arrestin1 mediates metastatic growth of breast cancer cells by facilitating HIF-1-dependent VEGF expression.” Oncogene 31, no. 3 (January 19, 2012): 282–92. https://doi.org/10.1038/onc.2011.238.
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    • Schulte, Gunnar, and Sudha K. Shenoy. “β-Arrestin and dishevelled coordinate biased signaling.” Proc Natl Acad Sci U S A 108, no. 50 (December 13, 2011): 19839–40. https://doi.org/10.1073/pnas.1117444108.
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    • Shenoy, Sudha K., and Howard A. Rockman. “Cardiovascular biology: heart fails without pump partner.” Nature 477, no. 7366 (September 28, 2011): 546–47. https://doi.org/10.1038/477546a.
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    • Sarker, Subhodeep, Kunhong Xiao, and Sudha K. Shenoy. “A tale of two sites: How ubiquitination of a G protein-coupled receptor is coupled to its lysosomal trafficking from distinct receptor domains.” Commun Integr Biol 4, no. 5 (September 2011): 528–31. https://doi.org/10.4161/cib.4.5.16458.
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    • Shenoy, Sudha K., and Robert J. Lefkowitz. “β-Arrestin-mediated receptor trafficking and signal transduction.” Trends Pharmacol Sci 32, no. 9 (September 2011): 521–33. https://doi.org/10.1016/j.tips.2011.05.002.
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    • Hara, Makoto R., Jeffrey J. Kovacs, Erin J. Whalen, Sudarshan Rajagopal, Ryan T. Strachan, Wayne Grant, Aaron J. Towers, et al. “A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1.” Nature 477, no. 7364 (August 21, 2011): 349–53. https://doi.org/10.1038/nature10368.
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    • Nobles, Kelly N., Kunhong Xiao, Seungkirl Ahn, Arun K. Shukla, Christopher M. Lam, Sudarshan Rajagopal, Ryan T. Strachan, et al. “Distinct phosphorylation sites on the β(2)-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin.” Sci Signal 4, no. 185 (August 9, 2011): ra51. https://doi.org/10.1126/scisignal.2001707.
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    • Xiao, Kunhong, and Sudha K. Shenoy. “Beta2-adrenergic receptor lysosomal trafficking is regulated by ubiquitination of lysyl residues in two distinct receptor domains.” J Biol Chem 286, no. 14 (April 8, 2011): 12785–95. https://doi.org/10.1074/jbc.M110.203091.
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    • Shenoy, Sudha K. “β-arrestin-biased signaling by the β-adrenergic receptors.” Curr Top Membr 67 (2011): 51–78. https://doi.org/10.1016/B978-0-12-384921-2.00003-3.
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    • Shenoy, Sudha K. “Visualizing G protein-coupled receptor signalsomes using confocal immunofluorescence microscopy.” Methods Mol Biol 756 (2011): 333–42. https://doi.org/10.1007/978-1-61779-160-4_20.
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    • Shukla, Arun K., Jihee Kim, Seungkirl Ahn, Kunhong Xiao, Sudha K. Shenoy, Wolfgang Liedtke, and Robert J. Lefkowitz. “Arresting a transient receptor potential (TRP) channel: beta-arrestin 1 mediates ubiquitination and functional down-regulation of TRPV4.” J Biol Chem 285, no. 39 (September 24, 2010): 30115–25. https://doi.org/10.1074/jbc.M110.141549.
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    • Berthouze, Magali, Vidya Venkataramanan, Yi Li, and Sudha K. Shenoy. “The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization.” Embo J 28, no. 12 (June 17, 2009): 1684–96. https://doi.org/10.1038/emboj.2009.128.
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    • Shenoy, Sudha K., Aalok S. Modi, Arun K. Shukla, Kunhong Xiao, Magali Berthouze, Seungkirl Ahn, Keith D. Wilkinson, William E. Miller, and Robert J. Lefkowitz. “Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2.” Proc Natl Acad Sci U S A 106, no. 16 (April 21, 2009): 6650–55. https://doi.org/10.1073/pnas.0901083106.
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    • Cai, Xinjiang, Jiao-Hui Wu, Sabrina T. Exum, Martin Oppermann, Richard T. Premont, Sudha K. Shenoy, and Neil J. Freedman. “Reciprocal regulation of the platelet-derived growth factor receptor-beta and G protein-coupled receptor kinase 5 by cross-phosphorylation: effects on catalysis.” Mol Pharmacol 75, no. 3 (March 2009): 626–36. https://doi.org/10.1124/mol.108.050278.
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    • Shenoy, Sudha K., Kunhong Xiao, Vidya Venkataramanan, Peter M. Snyder, Neil J. Freedman, and Allan M. Weissman. “Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptor.” J Biol Chem 283, no. 32 (August 8, 2008): 22166–76. https://doi.org/10.1074/jbc.M709668200.
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    • Shukla, Arun K., Jonathan D. Violin, Erin J. Whalen, Diane Gesty-Palmer, Sudha K. Shenoy, and Robert J. Lefkowitz. “Distinct conformational changes in beta-arrestin report biased agonism at seven-transmembrane receptors.” Proc Natl Acad Sci U S A 105, no. 29 (July 22, 2008): 9988–93. https://doi.org/10.1073/pnas.0804246105.
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    • Drake, Matthew T., Jonathan D. Violin, Erin J. Whalen, James W. Wisler, Sudha K. Shenoy, and Robert J. Lefkowitz. “beta-arrestin-biased agonism at the beta2-adrenergic receptor.” J Biol Chem 283, no. 9 (February 29, 2008): 5669–76. https://doi.org/10.1074/jbc.M708118200.
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    • Wisler, James W., Scott M. DeWire, Erin J. Whalen, Jonathan D. Violin, Matthew T. Drake, Seungkirl Ahn, Sudha K. Shenoy, and Robert J. Lefkowitz. “A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling.” Proc Natl Acad Sci U S A 104, no. 42 (October 16, 2007): 16657–62. https://doi.org/10.1073/pnas.0707936104.
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    • Shenoy, Sudha K., Larry S. Barak, Kunhong Xiao, Seungkirl Ahn, Magali Berthouze, Arun K. Shukla, Louis M. Luttrell, and Robert J. Lefkowitz. “Ubiquitination of beta-arrestin links seven-transmembrane receptor endocytosis and ERK activation.” J Biol Chem 282, no. 40 (October 5, 2007): 29549–62. https://doi.org/10.1074/jbc.M700852200.
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    • Xiao, Kunhong, Daniel B. McClatchy, Arun K. Shukla, Yang Zhao, Minyong Chen, Sudha K. Shenoy, John R. Yates, and Robert J. Lefkowitz. “Functional specialization of beta-arrestin interactions revealed by proteomic analysis.” Proc Natl Acad Sci U S A 104, no. 29 (July 17, 2007): 12011–16. https://doi.org/10.1073/pnas.0704849104.
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    • Shenoy, Sudha K. “Seven-transmembrane receptors and ubiquitination.” Circ Res 100, no. 8 (April 27, 2007): 1142–54. https://doi.org/10.1161/01.RES.0000261939.88744.5a.
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    • Girnita, Leonard, Sudha K. Shenoy, Bita Sehat, Radu Vasilcanu, Daiana Vasilcanu, Ada Girnita, Robert J. Lefkowitz, and Olle Larsson. “Beta-arrestin and Mdm2 mediate IGF-1 receptor-stimulated ERK activation and cell cycle progression.” J Biol Chem 282, no. 15 (April 13, 2007): 11329–38. https://doi.org/10.1074/jbc.M611526200.
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    • DeWire, Scott M., Seungkirl Ahn, Robert J. Lefkowitz, and Sudha K. Shenoy. “Beta-arrestins and cell signaling.” Annu Rev Physiol 69 (2007): 483–510. https://doi.org/10.1146/annurev.physiol.69.022405.154749.
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    • Drake, Matthew T., Sudha K. Shenoy, and Robert J. Lefkowitz. “Trafficking of G protein-coupled receptors.” Circ Res 99, no. 6 (September 15, 2006): 570–82. https://doi.org/10.1161/01.RES.0000242563.47507.ce.
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    • Shenoy, Sudha K., Matthew T. Drake, Christopher D. Nelson, Daniel A. Houtz, Kunhong Xiao, Srinivasan Madabushi, Eric Reiter, Richard T. Premont, Olivier Lichtarge, and Robert J. Lefkowitz. “beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor.” J Biol Chem 281, no. 2 (January 13, 2006): 1261–73. https://doi.org/10.1074/jbc.M506576200.
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    • Shenoy, Sudha K., and Robert J. Lefkowitz. “Receptor regulation: beta-arrestin moves up a notch.” Nat Cell Biol 7, no. 12 (December 2005): 1159–61. https://doi.org/10.1038/ncb1205-1059.
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    • Shenoy, Sudha K., and Robert J. Lefkowitz. “Angiotensin II-stimulated signaling through G proteins and beta-arrestin.” Sci Stke 2005, no. 311 (November 22, 2005): cm14. https://doi.org/10.1126/stke.3112005cm14.
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    • Shenoy, Sudha K., and Robert J. Lefkowitz. “Seven-transmembrane receptor signaling through beta-arrestin.” Sci Stke 2005, no. 308 (November 1, 2005): cm10. https://doi.org/10.1126/stke.2005/308/cm10.
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    • Girnita, Leonard, Sudha K. Shenoy, Bita Sehat, Radu Vasilcanu, Ada Girnita, Robert J. Lefkowitz, and Olle Larsson. “{beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase.” J Biol Chem 280, no. 26 (July 1, 2005): 24412–19. https://doi.org/10.1074/jbc.M501129200.
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    • Lefkowitz, Robert J., and Sudha K. Shenoy. “Transduction of receptor signals by beta-arrestins.” Science 308, no. 5721 (April 22, 2005): 512–17. https://doi.org/10.1126/science.1109237.
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    • Shenoy, Sudha K., and Robert J. Lefkowitz. “Receptor-specific ubiquitination of beta-arrestin directs assembly and targeting of seven-transmembrane receptor signalosomes.” J Biol Chem 280, no. 15 (April 15, 2005): 15315–24. https://doi.org/10.1074/jbc.M412418200.
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    • Xiao, Kunhong, Sudha K. Shenoy, Kelly Nobles, and Robert J. Lefkowitz. “Activation-dependent conformational changes in {beta}-arrestin 2.” J Biol Chem 279, no. 53 (December 31, 2004): 55744–53. https://doi.org/10.1074/jbc.M409785200.
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    • Ge, Lan, Sudha K. Shenoy, Robert J. Lefkowitz, and Kathryn DeFea. “Constitutive protease-activated receptor-2-mediated migration of MDA MB-231 breast cancer cells requires both beta-arrestin-1 and -2.” J Biol Chem 279, no. 53 (December 31, 2004): 55419–24. https://doi.org/10.1074/jbc.M410312200.
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    • Shenoy, Sudha K., and Robert J. Lefkowitz. “Resonating to the music of ubiquitination.” Nat Methods 1, no. 3 (December 2004): 191–93. https://doi.org/10.1038/nmeth1204-191.
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    • Usui, Isao, Takeshi Imamura, Jie Huang, Hiroaki Satoh, Sudha K. Shenoy, Robert J. Lefkowitz, Christopher J. Hupfeld, and Jerrold M. Olefsky. “beta-arrestin-1 competitively inhibits insulin-induced ubiquitination and degradation of insulin receptor substrate 1.” Mol Cell Biol 24, no. 20 (October 2004): 8929–37. https://doi.org/10.1128/MCB.24.20.8929-8937.2004.
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    • Ahn, Seungkirl, Sudha K. Shenoy, Huijun Wei, and Robert J. Lefkowitz. “Differential kinetic and spatial patterns of beta-arrestin and G protein-mediated ERK activation by the angiotensin II receptor.” J Biol Chem 279, no. 34 (August 20, 2004): 35518–25. https://doi.org/10.1074/jbc.M405878200.
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    • Martin, Negin P., Robert J. Lefkowitz, and Sudha K. Shenoy. “Regulation of V2 vasopressin receptor degradation by agonist-promoted ubiquitination.” J Biol Chem 278, no. 46 (November 14, 2003): 45954–59. https://doi.org/10.1074/jbc.M308285200.
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    • Shenoy, Sudha K., and Robert J. Lefkowitz. “Multifaceted roles of beta-arrestins in the regulation of seven-membrane-spanning receptor trafficking and signalling.” Biochem J 375, no. Pt 3 (November 1, 2003): 503–15. https://doi.org/10.1042/BJ20031076.
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    • Wei, Huijun, Seungkirl Ahn, Sudha K. Shenoy, Sadashiva S. Karnik, László Hunyady, Louis M. Luttrell, and Robert J. Lefkowitz. “Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2.” Proc Natl Acad Sci U S A 100, no. 19 (September 16, 2003): 10782–87. https://doi.org/10.1073/pnas.1834556100.
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    • Shenoy, Sudha K., and Robert J. Lefkowitz. “Trafficking patterns of beta-arrestin and G protein-coupled receptors determined by the kinetics of beta-arrestin deubiquitination.” J Biol Chem 278, no. 16 (April 18, 2003): 14498–506. https://doi.org/10.1074/jbc.M209626200.
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    • SHENOY, S. K. “Multifaceted roles of β-arrestins in the regulation of seven-transmembrane-spanning receptor trafficking and signaling.” Biochem J. 375 (2003): 503–15.
    • Lin, Fang-Tsyr, Wei Chen, Sudha Shenoy, Mei Cong, Sabrina T. Exum, and Robert J. Lefkowitz. “Phosphorylation of beta-arrestin2 regulates its function in internalization of beta(2)-adrenergic receptors.” Biochemistry 41, no. 34 (August 27, 2002): 10692–99. https://doi.org/10.1021/bi025705n.
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    • Shenoy, S. K., P. H. McDonald, T. A. Kohout, and R. J. Lefkowitz. “Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin.” Science 294, no. 5545 (November 9, 2001): 1307–13. https://doi.org/10.1126/science.1063866.
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    • Deng, K., S. K. Shenoy, S. C. Tso, L. Yu, and C. A. Yu. “Reconstitution of mitochondrial processing peptidase from the core proteins (subunits I and II) of bovine heart mitochondrial cytochrome bc(1) complex.” J Biol Chem 276, no. 9 (March 2, 2001): 6499–6505. https://doi.org/10.1074/jbc.M007128200.
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    • SHENOY, S. K. “Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin.” Science 294 (2001): 1307–13.
    • Tso, S. C., S. K. Shenoy, B. N. Quinn, and L. Yu. “Subunit IV of cytochrome bc1 complex from Rhodobacter sphaeroides. Localization of regions essential for interaction with the three-subunit core complex.” J Biol Chem 275, no. 20 (May 19, 2000): 15287–94. https://doi.org/10.1074/jbc.M907367199.
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    • Yu, C. A., H. Tian, L. Zhang, K. P. Deng, S. K. Shenoy, L. Yu, D. Xia, H. Kim, and J. Deisenhofer. “Structural basis of multifunctional bovine mitochondrial cytochrome bc1 complex.” J Bioenerg Biomembr 31, no. 3 (June 1999): 191–99. https://doi.org/10.1023/a:1005411510913.
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    • Yu, L., S. C. Tso, S. K. Shenoy, B. N. Quinn, and D. Xia. “The role of the supernumerary subunit of Rhodobacter sphaeroides cytochrome bc1 complex.” J Bioenerg Biomembr 31, no. 3 (June 1999): 251–57. https://doi.org/10.1023/a:1005423913639.
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    • Shenoy, S. K., L. Yu, and C. A. Yu. “Identification of quinone-binding and heme-ligating residues of the smallest membrane-anchoring subunit (QPs3) of bovine heart mitochondrial succinate:ubiquinone reductase.” J Biol Chem 274, no. 13 (March 26, 1999): 8717–22. https://doi.org/10.1074/jbc.274.13.8717.
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    • Shenoy, S. K., K. P. Deng, L. Yu, and C. A. Yu. “Cloning and functional expression of core proteins of bovine heart mitochondrial bc(1).” Biophysical Journal 74, no. 2 (February 1, 1998): A197–A197.
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    • Yu, C. A., S. K. Shenoy, K. P. Deng, L. Zhang, and L. Yu. “Reactivation, cloning and overexpression of matrix processing peptidase of the cytochrome bc(1) complex of bovine heart mitochondria.” Faseb Journal 11, no. 9 (July 31, 1997): A1280–A1280.
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    • Shenoy, S. K., L. Yu, and C. A. Yu. “The smallest membrane anchoring subunit (QPs3) of bovine heart mitochondrial succinate-ubiquinone reductase. Cloning, sequencing, topology, and Q-binding domain.” J Biol Chem 272, no. 28 (July 11, 1997): 17867–72. https://doi.org/10.1074/jbc.272.28.17867.
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    • Shenoy, S. K., L. Yu, and C. A. Yu. “Expression and properties of QPs3 of mitochondrial succinate-Q reductase.” Biophysical Journal 72, no. 2 (February 1, 1997): WP403–WP403.
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    • Shenoy, S. K., L. Yu, and C. A. Yu. “Cloning and sequencing of QPS3 of mitochondrial succinate -Q reductase.” Faseb Journal 10, no. 6 (December 1, 1996).
    • Shenoy, S. K., L. Yu, and C. A. Yu. “Cloning and sequences of QPS3 of mitochondrial succinate-Q reductase.” Faseb Journal 10, no. 6 (April 30, 1996): 2837–2837.
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    • Chen, Y. R., S. K. Shenoy, C. A. Yu, and L. Yu. “Identification of amino acid residues involved in structural and ubiquinone-binding functions of subunit IV of the cytochrome bc1 complex from Rhodobacter sphaeroides.” J Biol Chem 270, no. 19 (May 12, 1995): 11496–501. https://doi.org/10.1074/jbc.270.19.11496.
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  • Conference Papers

    • Jean-Charles, Pierre-Yves, Samuel Mon-Wei Yu, Lan Mao, Reddy Perra Kommadi, Zhushan Zhang, Jonathan Stiber, Dawn Bowles, et al. “Beta(1)-Adrenergic Receptor-induced Cardiac Contractility is dependent on MDM2-mediated GRK2 Turnover.” In Circulation Research, 119:E162–63. LIPPINCOTT WILLIAMS & WILKINS, 2016.
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    • Wu, Jiao-Hui, Lisheng Zhang, Pierre-Yves Jean-Charles, A Kyle Davidson, Leigh Brian, Rui Qi, Sudha K. Shenoy, and Neil J. Freedman. “Ubiquitin-Specific Protease 20 Attenuates Atherosclerosis through Activity in Smooth Muscle Cells.” In Circulation, Vol. 134. LIPPINCOTT WILLIAMS & WILKINS, 2016.
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    • Kirk, Jonathan A., Khalid Chakir, Kyounghwan Lee, Gianluigi Pironti, Mark J. Ranek, Richard S. Tunin, Pieter de Tombe, et al. “Pacemaker Induced Transient Asynchrony (PITA) Restores Contractile Reserve in Synchronous Heart Failure.” In Circulation Research, Vol. 117. LIPPINCOTT WILLIAMS & WILKINS, 2015.
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    • Han, Sang-oh, Reddy Peera Kommaddi, Vidya Venkataramanan, and Sudha K. Shenoy. “beta-arrestin2 and ARRDC proteins have distinct roles in beta(2)AR trafficking and signaling.” In Faseb Journal, Vol. 26, 2012.
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    • Patel, Chetan B., Priyesh A. Patel, Stephan G. Frangakis, Minyong Chen, Sudha K. Shenoy, Robert J. Lefkowitz, and Howard A. Rockman. “A Modified beta 1-adrenergic Receptor Demonstrates Bias Towards G Protein Receptor Kinase Phosphorylation.” In Circulation, 120:S800–801. LIPPINCOTT WILLIAMS & WILKINS, 2009.
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    • Shenoy, Sudha K., and Robert J. Lefkowitz. “Beta-arrestin-dependent signaling by seven-transmembrane receptors.” In Regulatory Peptides, 135:102–102. ELSEVIER SCIENCE BV, 2006.
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    • Shenoy, S. K., M. T. Drake, C. D. Nelson, D. A. Houtz, K. H. Xiao, S. Madabushi, E. Reiter, R. T. Premont, O. Lichtarge, and R. J. Lefkowitz. “beta-arrestin-dependent, G-protein-independent ERK1/2 activation by the beta(2)-adrenergic receptor.” In Circulation, 112:U26–U26. LIPPINCOTT WILLIAMS & WILKINS, 2005.
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    • Shenoy, S. K., M. T. Drake, C. D. Nelson, D. A. Houtz, K. H. Xiao, S. Madabushi, E. Reiter, R. T. Premont, O. Lichtarge, and R. J. Lefkowitz. “beta-arrestin dependent, G protein independent ERIK1/2 activation by the beta 2 adrenergic receptor.” In Circulation, 112:U47–U47. LIPPINCOTT WILLIAMS & WILKINS, 2005.
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    • Xiao, K. H., S. K. Shenoy, K. Nobles, T. G. Oas, and R. J. Lefkowitz. “Activation dependent conformational changes in beta-arrestin 2.” In Biophysical Journal, 88:554A-554A. BIOPHYSICAL SOCIETY, 2005.
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• Teaching & Mentoring
• 

  Recent Courses

  • CELLBIO 493: Research Independent Study 2023
  • CELLBIO 493: Research Independent Study 2022
  • BIOLOGY 293: Research Independent Study 2021
  • CELLBIO 493: Research Independent Study 2021

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