Current Appointments & Affiliations
Professor in Medicine
·
2023 - Present
Medicine, Cardiology,
Medicine
Professor in Cell Biology
·
2023 - Present
Cell Biology,
Basic Science Departments
Member of the Duke Cancer Institute
·
1999 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Publications
Emerging roles of ubiquitin-specific proteases in the cardiovascular system.
Journal Article Mol Pharmacol · November 24, 2025 The universal posttranslational modification ubiquitination was originally discovered in the 1980s as a tag appended to cellular proteins to mark them for degradation by the 26S proteasomal complex. Subsequent discoveries have established ubiquitination as ... Full text Link to item CiteInflammation-induced endothelial cell activation and angiogenic sprouting are downmodulated by ubiquitin-specific peptidase 20.
Journal Article bioRxiv · May 24, 2025 Nuclear factor-κB (NFκB) mediates inflammation-driven angiogenesis, which promotes growth of atherosclerotic plaques and tumors. The deubiquitinase ubiquitin-specific peptidase 20 (USP20) suppresses NFκB activation in vascular smooth muscle cells (SMCs) an ... Full text Link to item CiteUSP20 deletion promotes eccentric cardiac remodeling in response to pressure overload and increases mortality.
Journal Article Am J Physiol Heart Circ Physiol · November 1, 2024 Left ventricular hypertrophy (LVH) caused by chronic pressure overload with subsequent pathological remodeling is a major cardiovascular risk factor for heart failure and mortality. The role of deubiquitinases in LVH has not been well characterized. To def ... Full text Link to item CiteRecent Grants
iPediHeart: Interdisciplinary Research Training Program for Pediatric Heart Disease
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2025 - 2030The role of ubiquitination in glucagon-induced signaling bias and insulin secretion
ResearchPrincipal Investigator · Awarded by American Heart Association · 2023 - 2026Cell and Molecular Biology Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institute of General Medical Sciences · 2021 - 2026View All Grants
Education, Training & Certifications
Oklahoma State University, Stillwater ·
1998
Ph.D.