Current Appointments & Affiliations
Professor in Medicine
·
2023 - Present
Medicine, Cardiology,
Medicine
Professor in Cell Biology
·
2023 - Present
Cell Biology,
Basic Science Departments
Member of the Duke Cancer Institute
·
1999 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Publications
USP20 deletion promotes eccentric cardiac remodeling in response to pressure overload and increases mortality.
Journal Article Am J Physiol Heart Circ Physiol · November 1, 2024 Left ventricular hypertrophy (LVH) caused by chronic pressure overload with subsequent pathological remodeling is a major cardiovascular risk factor for heart failure and mortality. The role of deubiquitinases in LVH has not been well characterized. To def ... Full text Link to item Citeβ-adrenergic receptor signaling mediated by β-arrestins and its potential role in heart failure.
Journal Article Curr Opin Physiol · February 2024 The lethality of heart failure (HF), particularly in the context of post-acute sequelae SARS-CoV-2 infection (PASC)-related myocarditis, necessitates the discovery of the cellular pathways implicated in cardiovascular disease (CVD). We summarize the signal ... Full text Link to item CiteEditorial: Regulation of hormone and growth factor signalling by ubiquitin and ubiquitin-like protein modifications.
Journal Article Front Endocrinol (Lausanne) · 2024 Full text Link to item CiteRecent Grants
The role of ubiquitination in glucagon-induced signaling bias and insulin secretion
ResearchPrincipal Investigator · Awarded by American Heart Association · 2023 - 2026Cell and Molecular Biology Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2021 - 2026Regulation of myocardial GPCRs by USP20 in normal and hypertrophied heart
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2021 - 2025View All Grants
Education, Training & Certifications
Oklahoma State University, Stillwater ·
1998
Ph.D.