Stephen Richard Smith | Scholars@Duke

Stephen Richard Smith
Professor of Medicine

Ongoing work focuses on problems of immediate clinical relevance in renal and pancreas transplantation, including issues related to immunosuppression, infection, and cardiovascular events as well as hypertension.

Research methodologies employed include randomized clinical trials, cohort studies, and retrospective multivariable analyses based on the transplant database.

Current Appointments & Affiliations

Professor of Medicine, Medicine, Nephrology, Medicine 2007

Contact Information

2424 Erwin Rd., Suite 605, Durham, NC 27705
Duke Box 2747, Durham, NC 27710
smith060@mc.duke.edu (919) 660-6860

Background
Education, Training, & Certifications
- Fellowship, Nephrology, Duke University School of Medicine 1989 - 1991
- Intern, Internal Medicine, Duke University School of Medicine 1985 - 1986
- M.D., Duke University 1985
Duke Appointment History
- Interim Chief of the Division of Nephrology, Medicine, Nephrology, Medicine 2015 - 2016
- Associate Professor of Medicine, Medicine, Nephrology, Medicine 2006 - 2007
- Associate Clinical Professor of Medicine, Medicine, Nephrology, Medicine 2002 - 2006
- Associate Professor of Medicine, Medicine, Nephrology, Medicine 1998 - 2002
- Assistant Professor of Medicine, Medicine, Nephrology, Medicine 1993 - 1998
- Associate in the Department of Medicine, Medicine, Clinical Science Departments 1991 - 1993
Research
Selected Grants
- ACO Model and Comprehensive ESRD Care Initiative awarded by Deloitte Consulting LLP 2016 - 2017
Publications & Artistic Works
Selected Publications
- Book Sections
  - Smith, SR. "Renal Function in the Liver Transplant Patient." In Medical Care of the Liver Transplant Patient, edited by PG Killenberg and P Clavien.. (Chapter)
- Conference Papers
  - Pun, PH, Lehrich, RW, Smith, SR, and Middleton, JP. "Predictors of survival following sudden cardiac arrest in outpatient hemodialysis clinics." January 2006. Link to Item
  - Collins, BH, Marroquin, CE, Tuttle-Newhall, JE, Desai, DM, Smith, SR, Butterly, DW, Bollinger, RR, and Kuo, PC. "The management of end stage renal disease in the recipients of extrarenal transplants." 2004. Link to Item
  - Rocha, ATC, Rocha, PN, Smith, SR, and Palmer, S. "Chronic kidney disease after lung transplantation." 2004. Link to Item
  - Rocha, PN, Rocha, ATC, Palmer, S, and Smith, SR. "Acute renal failure after lung transplantation: Incidence, risk factors, and impact on perioperative morbidity and mortality." 2004. Link to Item
  - SVETKEY, LP, WILKINSON, R, DUNNICK, NR, SMITH, SR, DUNHAM, CB, LAMBERT, M, and KLOTMAN, PE. "CAPTOPRIL RENOGRAPHY IN THE DIAGNOSIS OF RENOVASCULAR DISEASE." December 1991. Full Text Link to Item
- Journal Articles
  - Weiner, DE, Park, M, Tighiouart, H, Joseph, AA, Carpenter, MA, Goyal, N, House, AA, Hsu, C-Y, Ix, JH, Jacques, PF, Kew, CE, Kim, SJ, Kusek, JW, Pesavento, TE, Pfeffer, MA, Smith, SR, Weir, MR, Levey, AS, and Bostom, AG. "Albuminuria and Allograft Failure, Cardiovascular Disease Events, and All-Cause Death in Stable Kidney Transplant Recipients: A Cohort Analysis of the FAVORIT Trial." American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation (July 20, 2018). Full Text
  - Lunyera, J, and Smith, SR. "Heavy metal nephropathy: considerations for exposure analysis." Kidney international 92, no. 3 (September 2017): 548-550. Full Text
  - Merhi, B, Shireman, T, Carpenter, MA, Kusek, JW, Jacques, P, Pfeffer, M, Rao, M, Foster, MC, Kim, SJ, Pesavento, TE, Smith, SR, Kew, CE, House, AA, Gohh, R, Weiner, DE, Levey, AS, Ix, JH, and Bostom, A. "Serum Phosphorus and Risk of Cardiovascular Disease, All-Cause Mortality, or Graft Failure in Kidney Transplant Recipients: An Ancillary Study of the FAVORIT Trial Cohort." American journal of kidney diseases : the official journal of the National Kidney Foundation 70, no. 3 (September 2017): 377-385. Full Text
  - Malone, AF, Phelan, PJ, Hall, G, Cetincelik, U, Homstad, A, Alonso, AS, Jiang, R, Lindsey, TB, Wu, G, Sparks, MA, Smith, SR, Webb, NJA, Kalra, PA, Adeyemo, AA, Shaw, AS, Conlon, PJ, Jennette, JC, Howell, DN, Winn, MP, and Gbadegesin, RA. "Rare hereditary COL4A3/COL4A4 variants may be mistaken for familial focal segmental glomerulosclerosis." Kidney International 86, no. 6 (December 2014): 1253-1259. Full Text Open Access Copy
  - Carpenter, MA, John, A, Weir, MR, Smith, SR, Hunsicker, L, Kasiske, BL, Kusek, JW, Bostom, A, Ivanova, A, Levey, AS, Solomon, S, Pesavento, T, and Weiner, DE. "BP, cardiovascular disease, and death in the Folic Acid for Vascular Outcome Reduction in Transplantation trial." Journal of the American Society of Nephrology : Jasn 25, no. 7 (July 2014): 1554-1562. Full Text
  - Phelan, PJ, Howell, DN, Smith, SR, and Ellis, MJ. "Late coexistent acute cellular and antibody-mediated rejection in non-sensitized renal transplant patients." Int Urol Nephrol 46, no. 5 (May 2014): 1031-1033. (Letter) Full Text Link to Item
  - Malone, AF, Phelan, PJ, Hall, G, Cetincelik, U, Homstad, A, Alonso, AS, Jiang, R, Lindsey, TB, Wu, G, Sparks, MA, Smith, SR, Webb, NJA, Kalra, PA, Adeyemo, AA, Shaw, AS, Conlon, PJ, Jennette, JC, Howell, DN, Winn, MP, and Gbadegesin, RA. "Rare hereditary COL4A3/COL4A4 variants may be mistaken for familial focal segmental glomerulosclerosis." Kidney International 86, no. 6 (January 1, 2014): 1253-1259. Full Text
  - Malone, AF, Sparks, MA, Howell, DN, Middleton, JP, Smith, SR, and Lehrich, RW. "IgG4-related tubulointerstitial nephritis associated with chronic lymphocytic leukemia." J Nephrol 26, no. 6 (November 2013): 1195-1198. Full Text Link to Item
  - Westervelt, JD, Alexander, BD, Costa, SF, Miller, SE, Howell, DN, and Smith, SR. "Detection of BK polyomavirus after kidney transplantation: a comparison of urine electron microscopy with plasma polymerase chain reaction." Clin Transplant 27, no. 1 (January 2013): E42-E48. Full Text Link to Item
  - Goetzinger, AM, Blumenthal, JA, O'Hayer, CV, Babyak, MA, Hoffman, BM, Ong, L, Davis, RD, Smith, SR, Rogers, JG, Milano, CA, Smith, AD, Kuo, PC, and Palmer, SM. "Stress and coping in caregivers of patients awaiting solid organ transplantation." Clinical Transplantation 26, no. 1 (January 2012): 97-104. Full Text
  - Westervelt, JD, and Smith, SR. "Can an arteriovenous dialysis access be salvaged when a clinically significant steal develops?." Semin Dial 24, no. 4 (July 2011): 392-393. Full Text Link to Item
  - Bostom, AG, Carpenter, MA, Kusek, JW, Levey, AS, Hunsicker, L, Pfeffer, MA, Selhub, J, Jacques, PF, Cole, E, Gravens-Mueller, L, House, AA, Kew, C, McKenney, JL, Pacheco-Silva, A, Pesavento, T, Pirsch, J, Smith, S, Solomon, S, and Weir, M. "Homocysteine-lowering and cardiovascular disease outcomes in kidney transplant recipients: primary results from the Folic Acid for Vascular Outcome Reduction in Transplantation trial." Circulation 123, no. 16 (April 11, 2011): 1763-1770. Full Text
  - Smith, SR. "Renal Function Posttransplant." (December 13, 2007): 460-472. (Chapter) Full Text
  - Pun, PH, Lehrich, RW, Smith, SR, and Middleton, JP. "Predictors of survival after cardiac arrest in outpatient hemodialysis clinics." Clin J Am Soc Nephrol 2, no. 3 (May 2007): 491-500. Full Text Link to Item
  - Lehrich, RW, Pun, PH, Tanenbaum, ND, Smith, SR, and Middleton, JP. "Automated external defibrillators and survival from cardiac arrest in the outpatient hemodialysis clinic." J Am Soc Nephrol 18, no. 1 (January 2007): 312-320. Full Text Link to Item
  - Plumb, TJ, Greenberg, A, Smith, SR, Butterly, DW, Pham, TTN, Fields, TA, and Howell, DN. "Postinfectious glomerulonephritis in renal allograft recipients." Transplantation 82, no. 9 (November 15, 2006): 1224-1228. Full Text Link to Item
  - Palmer, SM, Burch, LH, Mir, S, Smith, SR, Kuo, PC, Herczyk, WF, Reinsmoen, NL, and Schwartz, DA. "Donor polymorphisms in Toll-like receptor-4 influence the development of rejection after renal transplantation." Clin Transplant 20, no. 1 (January 2006): 30-36. Full Text Link to Item
  - Hanish, SI, Petersen, RP, Collins, BH, Tuttle-Newhall, J, Marroquin, CE, Kuo, PC, Butterly, DW, Smith, SR, and Desai, DM. "Obesity predicts increased overall complications following pancreas transplantation." Transplant Proc 37, no. 8 (October 2005): 3564-3566. Full Text Link to Item
  - Rocha, PN, Rocha, AT, Palmer, SM, Davis, RD, and Smith, SR. "Acute renal failure after lung transplantation: incidence, predictors and impact on perioperative morbidity and mortality." Am J Transplant 5, no. 6 (June 2005): 1469-1476. Full Text Link to Item
  - Lehrich, RW, Rocha, PN, Reinsmoen, N, Greenberg, A, Butterly, DW, Howell, DN, and Smith, SR. "Intravenous immunoglobulin and plasmapheresis in acute humoral rejection: experience in renal allograft transplantation." Hum Immunol 66, no. 4 (April 2005): 350-358. Full Text Link to Item
  - Rocha, PN, Plumb, TJ, Miller, SE, Howell, DN, and Smith, SR. "Risk factors for BK polyomavirus nephritis in renal allograft recipients." Clin Transplant 18, no. 4 (August 2004): 456-462. Full Text Link to Item
  - Green, BT, Tuttle-Newhall, J, Suhocki, P, Smith, SR, and O'Connor, JB. "Massive gastrointestinal hemorrhage due to rupture of a donor pancreatic artery pseudoaneurysm in a pancreas transplant patient." Clin Transplant 18, no. 1 (February 2004): 108-111. Link to Item
  - Kurella, M, Butterly, DW, and Smith, SR. "Post transplant erythrocytosis in hypercalcemic renal transplant recipients." Am J Transplant 3, no. 7 (July 2003): 873-877. Link to Item
  - Rocha, PN, Butterly, DW, Greenberg, A, Reddan, DN, Tuttle-Newhall, J, Collins, BH, Kuo, PC, Reinsmoen, N, Fields, T, Howell, DN, and Smith, SR. "Beneficial effect of plasmapheresis and intravenous immunoglobulin on renal allograft survival of patients with acute humoral rejection." Transplantation 75, no. 9 (May 15, 2003): 1490-1495. Full Text Link to Item
  - Emovon, OE, King, JAC, Smith, SR, Op't Holt, C, McDonald, F, Howell, DN, and Browne, BJ. "Clinical significance of eosinophils in suspicious or borderline renal allograft biopsies." Clin Nephrol 59, no. 5 (May 2003): 367-372. Link to Item
  - Smith, SR, and Butterly, DW. "Declining influence of race on the outcome of living-donor renal transplantation." Am J Transplant 2, no. 3 (March 2002): 282-286. Link to Item
  - Smith, SR, Butterly, DW, Alexander, BD, and Greenberg, A. "Viral infections after renal transplantation." Am J Kidney Dis 37, no. 4 (April 2001): 659-676. (Review) Link to Item
  - King, JAC, Howell, DN, McDonald, F, Holt, CLO, Smith, SR, Emovon, OE, and Browne, BJ. ""Borderline" changes in renal allograft biopsies: What is the clinical significance of eosinophils?." MODERN PATHOLOGY 14, no. 1 (January 2001): 189A-189A. Link to Item
  - King, JAC, Howell, DN, McDonald, F, Holt, CLO, Smith, SR, Emovon, OE, and Browne, BJ. ""Borderline" changes in renal allograft biopsies: What is the clinical significance of eosinophils?." LABORATORY INVESTIGATION 81, no. 1 (January 2001): 189A-189A. Link to Item
  - Howell, DN, Smith, SR, Butterly, DW, Klassen, PS, Krigman, HR, Burchette, JL, and Miller, SE. "Diagnosis and management of BK polyomavirus interstitial nephritis in renal transplant recipients." Transplantation 68, no. 9 (November 15, 1999): 1279-1288. Link to Item
  - Klassen, PS, Smith, SR, Butterly, DW, Greenberg, A, Krigman, HR, Burchette, JL, Howell, DN, and Miller, SE. "Diagnosis and clinical course of BK polyomavirus infection in renal transplant recipients." TRANSPLANTATION 67, no. 7 (April 15, 1999): S217-S217. Full Text Link to Item
  - Kurella, M, Smith, SR, and Butterly, DW. "The development of post transplant erythrocytosis in hypercalcemic renal transplant patients." TRANSPLANTATION 67, no. 7 (April 15, 1999): S169-S169. Full Text Link to Item
  - Smith, SR, Butterly, DW, Conlon, PJ, Harland, RC, and Emovon, OE. "Incidence of cytomegalovirus disease in renal transplantation without antilymphocyte induction: is prophylaxis necessary?." Transplant Proc 30, no. 5 (August 1998): 2097-2099. Link to Item
  - Conlon, PJ, Procop, GW, Fowler, V, Eloubeidi, MA, Smith, SR, and Sexton, DJ. "Predictors of prognosis and risk of acute renal failure in patients with Rocky Mountain spotted fever." Am J Med 101, no. 6 (December 1996): 621-626. Link to Item
  - Conlon, PJ, Smith, SR, Butterly, DW, and Brennan, DC. "Losartan in post-transplant erythrocytosis." Nephrol Dial Transplant 11, no. 12 (December 1996): 2524-2525. (Letter) Link to Item
  - Vallée, JP, Lazeyras, F, Sostman, HD, Smith, SR, Butterly, DW, Spritzer, CE, and Charles, HC. "Proton-decoupled phosphorus-31 magnetic resonance spectroscopy in the evaluation of native and well-functioning transplanted kidneys." Acad Radiol 3, no. 12 (December 1996): 1030-1037. Link to Item
  - Conlon, PJ, Brennan, DC, Pfaf, WW, Finn, WF, Gehr, T, Bollinger, RR, and Smith, SR. "Renal transplantation in adults with thrombotic thrombocytopenic purpura/haemolytic-uraemic syndrome." Nephrol Dial Transplant 11, no. 9 (September 1996): 1810-1814. Link to Item
  - Conlon, PJ, Fischer, CA, Levesque, MC, Smith, SR, St Clair, EW, Allen, NB, Fleming, JA, and Howell, DN. "Clinical, biochemical and pathological predictors of poor response to intravenous cyclophosphamide in patients with proliferative lupus nephritis." Clin Nephrol 46, no. 3 (September 1996): 170-175. Link to Item
  - Conlon, PJ, Procop, GJ, Fowler, V, Eloubeidi, MA, Smith, SR, and Sexton, DJ. "Predictors of prognosis and risk of acute renal failure in Rocky Mountain spotted fever." JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 7, no. 9 (September 1996): A0628-A0628. Link to Item
  - Kovalik, EC, Schwab, SJ, Gunnells, JC, Bowie, D, and Smith, SR. "No change in complication rate using spring-loaded gun compared to traditional percutaneous renal allograft biopsy techniques." Clin Nephrol 45, no. 6 (June 1996): 383-385. Link to Item
  - CONLON, PJ, BRENNAN, DC, PFAF, WW, FINN, W, GEHR, T, BOLLINGER, RR, and SMITH, SR. "RENAL-TRANSPLANTATION IN ADULTS WITH THROMBOTIC THROMBOCYTOPENIC PURPURA HEMOLYTIC-UREMIC SYNDROME (TTP/HUS)." JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 6, no. 3 (September 1995): 1078-1078. Link to Item
  - CONLON, PJ, FISHER, C, LEVESQUE, M, STCLAIR, EW, ALLEN, N, SMITH, SR, and HOWELL, DN. "PREDICTIVE VALUE OF RENAL BIOPSY IN PATIENTS WITH FOCAL AND DIFFUSE PROLIFERATIVE LUPUS NEPHRITIS (LN) TREATED WITH INTRAVENOUS CYCLOPHOSPHAMIDE." JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 6, no. 3 (September 1995): 415-415. Link to Item
  - Smith, SR, Minda, SA, Samsa, GP, Harrell, FE, Gunnells, JC, Coffman, TM, and Butterly, DW. "Late withdrawal of cyclosporine in stable renal transplant recipients." Am J Kidney Dis 26, no. 3 (September 1995): 487-494. Link to Item
  - Conlon, PJ, and Smith, SR. "Transmission of cancer with cadaveric donor organs." J Am Soc Nephrol 6, no. 1 (July 1995): 54-60. Link to Item
  - Conlon, PJ, Howell, DN, Macik, G, Kovalik, EC, and Smith, SR. "The renal manifestations and outcome of thrombotic thrombocytopenic purpura/hemolytic uremic syndrome in adults." Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association European Renal Association 10, no. 7 (January 1995): 1189-1193.
  - Smith, SR, Kubacki, VB, Rakhit, A, Martin, LL, Schaffer, AV, Jasani, MK, Hefty, DJ, Johnston, T, Cannon, C, and Bennett, WM. "Chronic thromboxane synthase inhibition with CGS 12970 in human cyclosporine nephrotoxicity." Transplantation 56, no. 6 (December 1993): 1422-1426. Link to Item
  - Smith, SR, Coffman, TM, and Svetkey, LP. "Effect of low-dose aspirin on thromboxane production and the antihypertensive effect of captopril." J Am Soc Nephrol 4, no. 5 (November 1993): 1133-1139. Link to Item
  - Smith, SR, Klotman, PE, and Svetkey, LP. "Potassium chloride lowers blood pressure and causes natriuresis in older patients with hypertension." J Am Soc Nephrol 2, no. 8 (February 1992): 1302-1309. Link to Item
  - Smith, SR, Creech, EA, Schaffer, AV, Martin, LL, Rakhit, A, Douglas, FL, Klotman, PE, and Coffman, TM. "Effects of thromboxane synthase inhibition with CGS 13080 in human cyclosporine nephrotoxicity." Kidney Int 41, no. 1 (January 1992): 199-205. Link to Item
  - Svetkey, LP, Wilkinson, R, Dunnick, NR, Smith, SR, Dunham, CB, Lambert, M, and Klotman, PE. "Captopril renography in the diagnosis of renovascular disease." Am J Hypertens 4, no. 12 Pt 2 (December 1991): 711S-715S. Link to Item
  - Svetkey, LP, Wilkinson, R, Dunnick, NR, Smith, SR, Dunham, CB, Lambert, M, and Klotman, PE. "Captopril Renography in the Diagnosis of Renovascular Disease." American Journal of Hypertension 4, no. 12 Pt 2 (December 1, 1991): 711S-715S. Full Text
  - Smith, SR, Svetkey, LP, and Dennis, VW. "Racial differences in the incidence and progression of renal diseases." Kidney International 40, no. 5 (November 1991): 815-822. Full Text
  - Svetkey, LP, Kadir, S, Dunnick, NR, Smith, SR, Dunham, CB, Lambert, M, and Klotman, PE. "Similar prevalence of renovascular hypertension in selected blacks and whites." Hypertension 17, no. 5 (May 1991): 678-683. Link to Item
  - COFFMAN, TM, SMITH, SR, CREECH, EA, SCHAFFER, AV, MARTIN, LL, RAKHIT, A, DOUGLAS, FL, and KLOTMAN, PE. "THE THROMBOXANE (TX) SYNTHETASE INHIBITOR CGS-13080 IMPROVES RENAL-ALLOGRAFT FUNCTION IN PATIENTS TAKING CYCLOSPORINE (CYA)." KIDNEY INTERNATIONAL 37, no. 1 (January 1990): 604-604. Link to Item
  - KLOTMAN, PE, SMITH, SR, VOLPP, BD, COFFMAN, TM, and YARGER, WE. "THROMBOXANE SYNTHETASE INHIBITION IMPROVES FUNCTION OF HYDRONEPHROTIC RAT KIDNEYS." AMERICAN JOURNAL OF PHYSIOLOGY 250, no. 2 (February 1986): F282-F287. Link to Item

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Education, Training, & Certifications

Duke Appointment History

Selected Grants

Selected Publications

Book Sections

Conference Papers

Journal Articles