Stephen Richard Smith | Scholars@Duke

Stephen Richard Smith
Professor of Medicine

Ongoing work focuses on problems of immediate clinical relevance in renal and pancreas transplantation, including issues related to immunosuppression, infection, and cardiovascular events as well as hypertension.

Research methodologies employed include randomized clinical trials, cohort studies, and retrospective multivariable analyses based on the transplant database.

Current Appointments & Affiliations

Professor of Medicine, Medicine, Nephrology, Medicine 2007

Contact Information

2424 Erwin Rd., Suite 605, Durham, NC 27705
Duke Box 2747, Durham, NC 27710
smith060@mc.duke.edu (919) 660-6860

Background
Education, Training, & Certifications
- Fellowship, Nephrology, Duke University School of Medicine 1989 - 1991
- Intern, Internal Medicine, Duke University School of Medicine 1985 - 1986
- M.D., Duke University 1985
Duke Appointment History
- Interim Chief of the Division of Nephrology, Medicine, Nephrology, Medicine 2015 - 2016
- Associate Professor of Medicine, Medicine, Nephrology, Medicine 2006 - 2007
- Associate Clinical Professor of Medicine, Medicine, Nephrology, Medicine 2002 - 2006
- Associate Professor of Medicine, Medicine, Nephrology, Medicine 1998 - 2002
- Assistant Professor of Medicine, Medicine, Nephrology, Medicine 1993 - 1998
- Associate in the Department of Medicine, Medicine, Clinical Science Departments 1991 - 1993
Research
Selected Grants
- ACO Model and Comprehensive ESRD Care Initiative awarded by Deloitte Consulting LLP 2016 - 2017
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Weiner, Daniel E., Meyeon Park, Hocine Tighiouart, Alin A. Joseph, Myra A. Carpenter, Nitender Goyal, Andrew A. House, et al. “Albuminuria and Allograft Failure, Cardiovascular Disease Events, and All-Cause Death in Stable Kidney Transplant Recipients: A Cohort Analysis of the FAVORIT Trial..” American Journal of Kidney Diseases : The Official Journal of the National Kidney Foundation 73, no. 1 (January 2019): 51–61. https://doi.org/10.1053/j.ajkd.2018.05.015.
    Full Text
  - Lunyera, Joseph, and Stephen R. Smith. “Heavy metal nephropathy: considerations for exposure analysis..” Kidney International 92, no. 3 (September 2017): 548–50. https://doi.org/10.1016/j.kint.2017.04.043.
    Full Text
  - Merhi, Basma, Theresa Shireman, Myra A. Carpenter, John W. Kusek, Paul Jacques, Marc Pfeffer, Madhumathi Rao, et al. “Serum Phosphorus and Risk of Cardiovascular Disease, All-Cause Mortality, or Graft Failure in Kidney Transplant Recipients: An Ancillary Study of the FAVORIT Trial Cohort..” American Journal of Kidney Diseases : The Official Journal of the National Kidney Foundation 70, no. 3 (September 2017): 377–85. https://doi.org/10.1053/j.ajkd.2017.04.014.
    Full Text
  - Malone, Andrew F., Paul J. Phelan, Gentzon Hall, Umran Cetincelik, Alison Homstad, Andrea S. Alonso, Ruiji Jiang, et al. “Rare hereditary COL4A3/COL4A4 variants may be mistaken for familial focal segmental glomerulosclerosis..” Kidney International 86, no. 6 (December 2014): 1253–59. https://doi.org/10.1038/ki.2014.305.
    Full Text Open Access Copy
  - Carpenter, Myra A., Alin John, Matthew R. Weir, Stephen R. Smith, Lawrence Hunsicker, Bertram L. Kasiske, John W. Kusek, et al. “BP, cardiovascular disease, and death in the Folic Acid for Vascular Outcome Reduction in Transplantation trial..” Journal of the American Society of Nephrology : Jasn 25, no. 7 (July 2014): 1554–62. https://doi.org/10.1681/ASN.2013040435.
    Full Text
  - Phelan, P. J., D. N. Howell, S. R. Smith, and M. J. Ellis. “Late coexistent acute cellular and antibody-mediated rejection in non-sensitized renal transplant patients..” International Urology and Nephrology 46, no. 5 (May 2014): 1031–33. https://doi.org/10.1007/s11255-013-0525-9.
    Full Text
  - Malone, Andrew F., Matthew A. Sparks, David N. Howell, John Paul Middleton, Stephen R. Smith, and Ruediger W. Lehrich. “IgG4-related tubulointerstitial nephritis associated with chronic lymphocytic leukemia..” J Nephrol 26, no. 6 (November 2013): 1195–98. https://doi.org/10.5301/jn.5000298.
    Full Text Link to Item
  - Westervelt, Justin D., Barbara D. Alexander, Sylvia F. Costa, Sara E. Miller, David N. Howell, and Stephen R. Smith. “Detection of BK polyomavirus after kidney transplantation: a comparison of urine electron microscopy with plasma polymerase chain reaction..” Clinical Transplantation 27, no. 1 (January 2013): E42–48. https://doi.org/10.1111/ctr.12048.
    Full Text
  - Goetzinger, Amy M., James A. Blumenthal, C Virginia O’Hayer, Michael A. Babyak, Benson M. Hoffman, Lephuong Ong, R Duane Davis, et al. “Stress and coping in caregivers of patients awaiting solid organ transplantation..” Clinical Transplantation 26, no. 1 (January 2012): 97–104. https://doi.org/10.1111/j.1399-0012.2011.01431.x.
    Full Text
  - Westervelt, Justin D., and Stephen R. Smith. “Can an arteriovenous dialysis access be salvaged when a clinically significant steal develops?.” Seminars in Dialysis 24, no. 4 (July 2011): 392–93. https://doi.org/10.1111/j.1525-139x.2011.00910.x.
    Full Text
  - Bostom, Andrew G., Myra A. Carpenter, John W. Kusek, Andrew S. Levey, Lawrence Hunsicker, Marc A. Pfeffer, Jacob Selhub, et al. “Homocysteine-lowering and cardiovascular disease outcomes in kidney transplant recipients: primary results from the Folic Acid for Vascular Outcome Reduction in Transplantation trial..” Circulation 123, no. 16 (April 11, 2011): 1763–70. https://doi.org/10.1161/CIRCULATIONAHA.110.000588.
    Full Text
  - Smith, S. R. “Renal Function Posttransplant,” December 13, 2007, 460–72. https://doi.org/10.1002/9780470751541.ch26.
    Full Text
  - Pun, Patrick H., Ruediger W. Lehrich, Stephen R. Smith, and John P. Middleton. “Predictors of survival after cardiac arrest in outpatient hemodialysis clinics..” Clinical Journal of the American Society of Nephrology : Cjasn 2, no. 3 (May 2007): 491–500. https://doi.org/10.2215/cjn.02360706.
    Full Text
  - Lehrich, Ruediger W., Patrick H. Pun, Nadine D. Tanenbaum, Stephen R. Smith, and John P. Middleton. “Automated external defibrillators and survival from cardiac arrest in the outpatient hemodialysis clinic..” Journal of the American Society of Nephrology : Jasn 18, no. 1 (January 2007): 312–20. https://doi.org/10.1681/asn.2006040392.
    Full Text
  - Plumb, Troy J., Arthur Greenberg, Stephen R. Smith, David W. Butterly, Teresa Tram N. Pham, Timothy A. Fields, and David N. Howell. “Postinfectious glomerulonephritis in renal allograft recipients..” Transplantation 82, no. 9 (November 2006): 1224–28. https://doi.org/10.1097/01.tp.0000232327.09757.7b.
    Full Text
  - Palmer, Scott M., Lauranell H. Burch, Saad Mir, Stephen R. Smith, Paul C. Kuo, Walter F. Herczyk, Nancy L. Reinsmoen, and David A. Schwartz. “Donor polymorphisms in Toll-like receptor-4 influence the development of rejection after renal transplantation..” Clinical Transplantation 20, no. 1 (January 2006): 30–36. https://doi.org/10.1111/j.1399-0012.2005.00436.x.
    Full Text
  - Hanish, S. I., R. P. Petersen, B. H. Collins, J. Tuttle-Newhall, C. E. Marroquin, P. C. Kuo, D. W. Butterly, S. R. Smith, and D. M. Desai. “Obesity predicts increased overall complications following pancreas transplantation..” Transplantation Proceedings 37, no. 8 (October 2005): 3564–66. https://doi.org/10.1016/j.transproceed.2005.09.068.
    Full Text
  - Rocha, Paulo N., Ana T. Rocha, Scott M. Palmer, R Duane Davis, and Stephen R. Smith. “Acute renal failure after lung transplantation: incidence, predictors and impact on perioperative morbidity and mortality..” American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons 5, no. 6 (June 2005): 1469–76. https://doi.org/10.1111/j.1600-6143.2005.00867.x.
    Full Text
  - Lehrich, Ruediger W., Paulo N. Rocha, Nancy Reinsmoen, Arthur Greenberg, David W. Butterly, David N. Howell, and Stephen R. Smith. “Intravenous immunoglobulin and plasmapheresis in acute humoral rejection: experience in renal allograft transplantation..” Human Immunology 66, no. 4 (April 2005): 350–58. https://doi.org/10.1016/j.humimm.2005.01.028.
    Full Text
  - Rocha, Paulo N., Troy J. Plumb, Sara E. Miller, David N. Howell, and Stephen R. Smith. “Risk factors for BK polyomavirus nephritis in renal allograft recipients..” Clinical Transplantation 18, no. 4 (August 2004): 456–62. https://doi.org/10.1111/j.1399-0012.2004.00191.x.
    Full Text
  - Green, Bryan T., Janet Tuttle-Newhall, Paul Suhocki, Stephen R. Smith, and J Barry O’Connor. “Massive gastrointestinal hemorrhage due to rupture of a donor pancreatic artery pseudoaneurysm in a pancreas transplant patient..” Clinical Transplantation 18, no. 1 (February 2004): 108–11. https://doi.org/10.1111/j.1399-0012.2004.00111.x.
    Full Text
  - Kurella, Manjula, David W. Butterly, and Stephen R. Smith. “Post transplant erythrocytosis in hypercalcemic renal transplant recipients..” American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons 3, no. 7 (July 2003): 873–77. https://doi.org/10.1034/j.1600-6143.2003.00131.x.
    Full Text
  - Emovon, O. E., J. A. King, S. R. Smith, C. Op’t Holt, F. McDonald, D. N. Howell, and B. J. Browne. “Clinical significance of eosinophils in suspicious or borderline renal allograft biopsies..” Clinical Nephrology 59, no. 5 (May 2003): 367–72.
  - Rocha, Paulo N., David W. Butterly, Arthur Greenberg, Donal N. Reddan, Janet Tuttle-Newhall, Bradley H. Collins, Paul C. Kuo, et al. “Beneficial effect of plasmapheresis and intravenous immunoglobulin on renal allograft survival of patients with acute humoral rejection..” Transplantation 75, no. 9 (May 2003): 1490–95. https://doi.org/10.1097/01.tp.0000060252.57111.ac.
    Full Text
  - Smith, Stephen R., and David W. Butterly. “Declining influence of race on the outcome of living-donor renal transplantation..” American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2, no. 3 (March 2002): 282–86. https://doi.org/10.1034/j.1600-6143.2002.20314.x.
    Full Text
  - Smith, S. R., D. W. Butterly, B. D. Alexander, and A. Greenberg. “Viral infections after renal transplantation..” American Journal of Kidney Diseases : The Official Journal of the National Kidney Foundation 37, no. 4 (April 2001): 659–76. https://doi.org/10.1016/s0272-6386(01)80114-1.
    Full Text
  - King, J. A. C., D. N. Howell, F. McDonald, C. L. O. Holt, S. R. Smith, O. E. Emovon, and B. J. Browne. “"Borderline" changes in renal allograft biopsies: What is the clinical significance of eosinophils?.” Modern Pathology 14, no. 1 (January 1, 2001): 189A-189A.
    Link to Item
  - Howell, D. N., S. R. Smith, D. W. Butterly, P. S. Klassen, H. R. Krigman, J. L. Burchette, and S. E. Miller. “Diagnosis and management of BK polyomavirus interstitial nephritis in renal transplant recipients..” Transplantation 68, no. 9 (November 1999): 1279–88. https://doi.org/10.1097/00007890-199911150-00011.
    Full Text
  - Klassen, P. S., S. R. Smith, D. W. Butterly, A. Greenberg, H. R. Krigman, J. L. Burchette, D. N. Howell, and S. E. Miller. “DIAGNOSIS AND CLINICAL COURSE OF BK POLYOMAVIRUS INFECTION IN RENAL TRANSPLANT RECIPIENTS..” Transplantation 67, no. 7 (April 1999): S217–S217. https://doi.org/10.1097/00007890-199904150-00868.
    Full Text
  - Kurella, M., S. R. Smith, and D. W. Butterly. “THE DEVELOPMENT OF POST TRANSPLANT ERYTHROCYTOSIS IN HYPERCALCEMIC RENAL TRANSPLANT PATIENTS.” Transplantation 67, no. 7 (April 1999): S169–S169. https://doi.org/10.1097/00007890-199904150-00675.
    Full Text
  - Smith, S. R., D. W. Butterly, P. J. Conlon, R. C. Harland, and O. E. Emovon. “Incidence of cytomegalovirus disease in renal transplantation without antilymphocyte induction: is prophylaxis necessary?.” Transplantation Proceedings 30, no. 5 (August 1998): 2097–99. https://doi.org/10.1016/s0041-1345(98)00551-x.
    Full Text
  - Conlon, P. J., G. W. Procop, V. Fowler, M. A. Eloubeidi, S. R. Smith, and D. J. Sexton. “Predictors of prognosis and risk of acute renal failure in patients with Rocky Mountain spotted fever..” The American Journal of Medicine 101, no. 6 (December 1996): 621–26. https://doi.org/10.1016/s0002-9343(96)00332-4.
    Full Text
  - Conlon, P. J., S. R. Smith, D. W. Butterly, and D. C. Brennan. “Losartan in post-transplant erythrocytosis..” Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association European Renal Association 11, no. 12 (December 1996): 2524–25. https://doi.org/10.1093/oxfordjournals.ndt.a027238.
    Full Text
  - Vallée, J. P., F. Lazeyras, H. D. Sostman, S. R. Smith, D. W. Butterly, C. E. Spritzer, and H. C. Charles. “Proton-decoupled phosphorus-31 magnetic resonance spectroscopy in the evaluation of native and well-functioning transplanted kidneys..” Academic Radiology 3, no. 12 (December 1996): 1030–37. https://doi.org/10.1016/s1076-6332(96)80040-7.
    Full Text
  - Conlon, P. J., C. A. Fischer, M. C. Levesque, S. R. Smith, E. W. St Clair, N. B. Allen, J. A. Fleming, and D. N. Howell. “Clinical, biochemical and pathological predictors of poor response to intravenous cyclophosphamide in patients with proliferative lupus nephritis..” Clinical Nephrology 46, no. 3 (September 1996): 170–75.
  - Conlon, P. J., D. C. Brennan, W. W. Pfaf, W. F. Finn, T. Gehr, R. R. Bollinger, and S. R. Smith. “Renal transplantation in adults with thrombotic thrombocytopenic purpura/haemolytic-uraemic syndrome..” Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association European Renal Association 11, no. 9 (September 1996): 1810–14. https://doi.org/10.1093/oxfordjournals.ndt.a027673.
    Full Text
  - Conlon, P. J., G. J. Procop, V. Fowler, M. A. Eloubeidi, S. R. Smith, and D. J. Sexton. “Predictors of prognosis and risk of acute renal failure in Rocky Mountain spotted fever..” Journal of the American Society of Nephrology 7, no. 9 (September 1, 1996): A0628–A0628.
    Link to Item
  - Kovalik, E. C., S. J. Schwab, J. C. Gunnells, D. Bowie, and S. R. Smith. “No change in complication rate using spring-loaded gun compared to traditional percutaneous renal allograft biopsy techniques..” Clinical Nephrology 45, no. 6 (June 1996): 383–85.
  - CONLON, P. J., C. FISHER, M. LEVESQUE, E. W. STCLAIR, N. ALLEN, S. R. SMITH, and D. N. HOWELL. “PREDICTIVE VALUE OF RENAL BIOPSY IN PATIENTS WITH FOCAL AND DIFFUSE PROLIFERATIVE LUPUS NEPHRITIS (LN) TREATED WITH INTRAVENOUS CYCLOPHOSPHAMIDE.” Journal of the American Society of Nephrology 6, no. 3 (September 1, 1995): 415–415.
    Link to Item
  - CONLON, P. J., D. C. BRENNAN, W. W. PFAF, W. FINN, T. GEHR, R. R. BOLLINGER, and S. R. SMITH. “RENAL-TRANSPLANTATION IN ADULTS WITH THROMBOTIC THROMBOCYTOPENIC PURPURA HEMOLYTIC-UREMIC SYNDROME (TTP/HUS).” Journal of the American Society of Nephrology 6, no. 3 (September 1, 1995): 1078–1078.
    Link to Item
  - Smith, S. R., S. A. Minda, G. P. Samsa, F. E. Harrell, J. C. Gunnells, T. M. Coffman, and D. W. Butterly. “Late withdrawal of cyclosporine in stable renal transplant recipients..” American Journal of Kidney Diseases : The Official Journal of the National Kidney Foundation 26, no. 3 (September 1995): 487–94. https://doi.org/10.1016/0272-6386(95)90495-6.
    Full Text
  - Conlon, P. J., and S. R. Smith. “Transmission of cancer with cadaveric donor organs..” Journal of the American Society of Nephrology : Jasn 6, no. 1 (July 1995): 54–60.
  - Conlon, P. J., D. N. Howell, G. Macik, E. C. Kovalik, and S. R. Smith. “The renal manifestations and outcome of thrombotic thrombocytopenic purpura/hemolytic uremic syndrome in adults..” Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association European Renal Association 10, no. 7 (January 1995): 1189–93.
  - Smith, S. R., V. B. Kubacki, A. Rakhit, L. L. Martin, A. V. Schaffer, M. K. Jasani, D. J. Hefty, T. Johnston, C. Cannon, and W. M. Bennett. “Chronic thromboxane synthase inhibition with CGS 12970 in human cyclosporine nephrotoxicity..” Transplantation 56, no. 6 (December 1993): 1422–26.
  - Smith, S. R., T. M. Coffman, and L. P. Svetkey. “Effect of low-dose aspirin on thromboxane production and the antihypertensive effect of captopril..” Journal of the American Society of Nephrology : Jasn 4, no. 5 (November 1993): 1133–39.
  - Smith, S. R., P. E. Klotman, and L. P. Svetkey. “Potassium chloride lowers blood pressure and causes natriuresis in older patients with hypertension..” Journal of the American Society of Nephrology : Jasn 2, no. 8 (February 1992): 1302–9.
  - Smith, S. R., E. A. Creech, A. V. Schaffer, L. L. Martin, A. Rakhit, F. L. Douglas, P. E. Klotman, and T. M. Coffman. “Effects of thromboxane synthase inhibition with CGS 13080 in human cyclosporine nephrotoxicity..” Kidney International 41, no. 1 (January 1992): 199–205. https://doi.org/10.1038/ki.1992.27.
    Full Text
  - Svetkey, L. P., R. Wilkinson, N. R. Dunnick, S. R. Smith, C. B. Dunham, M. Lambert, and P. E. Klotman. “Captopril renography in the diagnosis of renovascular disease..” American Journal of Hypertension 4, no. 12 Pt 2 (December 1991): 711S-715S. https://doi.org/10.1093/ajh/4.12.711s.
    Full Text
  - Smith, S. R., L. P. Svetkey, and V. W. Dennis. “Racial differences in the incidence and progression of renal diseases..” Kidney International 40, no. 5 (November 1991): 815–22. https://doi.org/10.1038/ki.1991.281.
    Full Text
  - Svetkey, L. P., S. Kadir, N. R. Dunnick, S. R. Smith, C. B. Dunham, M. Lambert, and P. E. Klotman. “Similar prevalence of renovascular hypertension in selected blacks and whites..” Hypertension (Dallas, Tex. : 1979) 17, no. 5 (May 1991): 678–83. https://doi.org/10.1161/01.hyp.17.5.678.
    Full Text
  - Svetkey, L. P., R. Wilkinson, N. R. Dunnick, S. R. Smith, C. B. Dunham, M. Lambert, and P. E. Klotman. “Captopril renography in the diagnosis of renovascular disease.” American Journal of Hypertension 4, no. 12 (January 1, 1991): 711S-715S. https://doi.org/10.1093/ajh/4.12.711S.
    Full Text
  - COFFMAN, T. M., S. R. SMITH, E. A. CREECH, A. V. SCHAFFER, L. L. MARTIN, A. RAKHIT, F. L. DOUGLAS, and P. E. KLOTMAN. “THE THROMBOXANE (TX) SYNTHETASE INHIBITOR CGS-13080 IMPROVES RENAL-ALLOGRAFT FUNCTION IN PATIENTS TAKING CYCLOSPORINE (CYA).” Kidney International 37, no. 1 (January 1, 1990): 604–604.
    Link to Item
  - KLOTMAN, P. E., S. R. SMITH, B. D. VOLPP, T. M. COFFMAN, and W. E. YARGER. “THROMBOXANE SYNTHETASE INHIBITION IMPROVES FUNCTION OF HYDRONEPHROTIC RAT KIDNEYS.” American Journal of Physiology 250, no. 2 (February 1, 1986): F282–87.
    Link to Item
- Book Sections
  - Smith, S. R. “Renal Function in the Liver Transplant Patient.” In Medical Care of the Liver Transplant Patient, edited by P. G. Killenberg and P. Clavien, n.d.
- Conference Papers
  - Pun, P. H., R. W. Lehrich, S. R. Smith, and J. P. Middleton. “Predictors of survival following sudden cardiac arrest in outpatient hemodialysis clinics..” In Journal of Investigative Medicine, 54:S298–S298. B C DECKER INC, 2006.
    Link to Item
  - Collins, B. H., C. E. Marroquin, J. E. Tuttle-Newhall, D. M. Desai, S. R. Smith, D. W. Butterly, R. R. Bollinger, and P. C. Kuo. “The management of end stage renal disease in the recipients of extrarenal transplants.” In American Journal of Transplantation, 4:537–537. BLACKWELL MUNKSGAARD, 2004.
    Link to Item
  - Rocha, A. T. C., P. N. Rocha, S. R. Smith, and S. Palmer. “Chronic kidney disease after lung transplantation..” In American Journal of Transplantation, 4:226–226. BLACKWELL MUNKSGAARD, 2004.
    Link to Item
  - Rocha, P. N., A. T. C. Rocha, S. Palmer, and S. R. Smith. “Acute renal failure after lung transplantation: Incidence, risk factors, and impact on perioperative morbidity and mortality..” In American Journal of Transplantation, 4:270–270. BLACKWELL MUNKSGAARD, 2004.
    Link to Item
  - SVETKEY, L. P., R. WILKINSON, N. R. DUNNICK, S. R. SMITH, C. B. DUNHAM, M. LAMBERT, and P. E. KLOTMAN. “CAPTOPRIL RENOGRAPHY IN THE DIAGNOSIS OF RENOVASCULAR DISEASE.” In American Journal of Hypertension, 4:S711–15, 1991. https://doi.org/10.1093/ajh/4.12.711S.
    Full Text Link to Item

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.

Education, Training, & Certifications

Duke Appointment History

Selected Grants

Selected Publications

Academic Articles

Book Sections

Conference Papers