Current Appointments & Affiliations
House Staff
Medicine,
Clinical Science Departments
House Staff
Medicine, Rheumatology and Immunology,
Medicine
Recent Publications
What's Atypical about Human B cells after Allogeneic Stem Cell Transplantation?
Journal Article Journal of leukocyte biology · April 2025 Atypical B cells or age-associated B cells (ABCs) represent an alternative lineage of memory B cells. Emerging evidence suggests that context influences the apparent functional heterogeneity of ABCs. While data support a protective role for ABCs in the set ... Full text CiteHeightened TLR7 signaling primes BCR-activated B cells in chronic graft-versus-host disease for effector functions.
Journal Article Blood Adv · February 13, 2024 Chronic graft-versus-host disease (cGVHD) is a debilitating, autoimmune-like syndrome that can occur after allogeneic hematopoietic stem cell transplantation. Constitutively activated B cells contribute to ongoing alloreactivity and autoreactivity in patie ... Full text Open Access Link to item CiteSingle-cell landscape analysis unravels molecular programming of the human B cell compartment in chronic GVHD.
Journal Article JCI Insight · June 8, 2023 Alloreactivity can drive autoimmune syndromes. After allogeneic hematopoietic stem cell transplantation (allo-HCT), chronic graft-versus-host disease (cGVHD), a B cell-associated autoimmune-like syndrome, commonly occurs. Because donor-derived B cells cont ... Full text Open Access Link to item CiteRecent Grants
B Cell-Fibroblast Crosstalk Promotes Chronic GVHD of the Lung
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2024 - 2026View All Grants