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Sophia Dorcheva Sarafova

Adjunct Associate Professor in the Department of Immunology
Integrative Immunobiology
Immunology, Box 3010, Durham, NC 27710

Current Appointments & Affiliations


Adjunct Associate Professor in the Department of Immunology · 2012 - Present Integrative Immunobiology, Basic Science Departments

Recent Publications


A conserved element in the first intron of Cd4 has a lineage specific, TCR signal-responsive, canonical enhancer function that matches the timing of cell surface CD4 upregulation required to prevent lineage choice error.

Journal Article Front Immunol · 2024 INTRODUCTION: The regulation of Cd4 expression during T-cell development and immune responses is essential for proper lineage commitment and function in the periphery. However, the mechanisms of genetic and epigenetic regulation are complex, and their inte ... Full text Open Access Link to item Cite

Sequence-Defined Heteromultivalent Precision Glycomacromolecules Bearing Sulfonated/Sulfated Nonglycosidic Moieties Preferentially Bind Galectin-3 and Delay Wound Healing of a Galectin-3 Positive Tumor Cell Line in an In Vitro Wound Scratch Assay.

Journal Article Macromol Biosci · September 2020 Within this work, a new class of sequence-defined heteromultivalent glycomacromolecules bearing lactose residues and nonglycosidic motifs for probing glycoconjugate recognition in carbohydrate recognition domain (CRD) of galectin-3 is presented. Galectins, ... Full text Open Access Link to item Cite
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Education, Training & Certifications


Columbia University · 2000 Ph.D.