Robert Frank Spurney | Scholars@Duke

Robert Frank Spurney
Professor of Medicine

Dr. Spurney’s research has focused on the role of G protein coupled receptors (GPCRs) in regulating cellular physiology both in normal and disease states as well as the regulatory mechanisms that modulate GPCR responsiveness at the molecular level. These studies have centered on two major themes. The first investigates the role of GPCR signaling pathways in regulating podocyte function using cultured podocytes and transgenic animals models. The second area of research involves the role of GPCR kinases (GRKs) and arrestin scaffolding proteins in modulating GPCR signaling in bone forming osteoblasts using cultured osteoblast cell lines as well as genetically modified mice including transgenic models and knockout animals. The long-term goal of these studies is to identify novel therapeutic targets that may useful for treating disease processes such as glomerulonephritis and osteoporosis.

Please see the Duke Nephrology Division website for more detailed information.

Current Appointments & Affiliations

Professor of Medicine, Medicine, Nephrology, Medicine 2012
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 1983

Contact Information

Box 103015, Duke University Medical Center, Durham, NC 27710
Duke Box 103015, Durham, NC 27710
spurn002@mc.duke.edu (919) 684-9729

Background
Education, Training, & Certifications
- Fellow in Nephrology, Medicine, Duke University 1987 - 1990
- Senior Assistant Resident, Medicine, Duke University 1986 - 1987
- Resident in Pathology, Pathology, Duke University 1985 - 1986
- Medical Resident, Medicine, Duke University 1983 - 1985
- M.D., Ohio State University 1983
Duke Appointment History
- Associate Professor of Medicine, Medicine, Nephrology, Medicine 2003 - 2011
- Associate Professor of Medicine, Medicine, Nephrology, Medicine 1997 - 2003
- Assistant Professor of Medicine, Medicine, Nephrology, Medicine 1993 - 1997
- Assistant Clinical Professor of Medicine, Medicine, Nephrology, Medicine 1992 - 1993
- Associate in the Department of Medicine, Medicine, Clinical Science Departments 1990 - 1992
Research
Selected Grants
- Promoting Podocyte Protective Natriuretic Peptide Signaling in Proteinuric Kidney Diseases awarded by Department of Defense 2019 - 2022
- Duke Training Grant in Nephrology awarded by National Institutes of Health 1995 - 2022
- The Role of Interleukin-15 Receptor-alpha Variants in the Pathogenesis of FSGS awarded by National Institutes of Health 2017 - 2022
- Transmission electron microscope (TEM) awarded by National Institutes of Health 2019 - 2020
- IPA - Liming Wang awarded by Durham Veterans Affairs Medical Center 2019
- IPA - Robert Griffiths awarded by Durham Veterans Affairs Medical Center 2019
- Targeting TRPC6 to treat focal segmental glomerulosclerosis (FSGS) awarded by Amgen, Inc. 2016 - 2019
- IPA extension - Cindy Chen awarded by Durham Veterans Affairs Medical Center 2019
- Functional and Phenotypic Characterization of a New FSGS Gene awarded by National Institutes of Health 2014 - 2019
- IPA extension - Liming Wang awarded by Durham Veterans Affairs Medical Center 2018 - 2019
- IPA - Cindy Chen awarded by Durham Veterans Affairs Medical Center 2018 - 2019
- Gene Discovery in Autosomal Dominant Focal Segmental Glomerulosclerosis awarded by National Institutes of Health 2012 - 2018
- Serial Block Face Scanning Electron Microscope awarded by National Institutes of Health 2016 - 2018
- The role of dendritic cell-mediated T cell activation in hypertension awarded by National Institutes of Health 2017
- Role of Gq Signaling in Promoting Podocyte Injury in Diabetes Mellitus awarded by National Institutes of Health 2011 - 2016
- IPA Extensioin - Wang awarded by Durham Veterans Affairs Medical Center 2013 - 2014
- IPA - Liming Wang awarded by Durham Veterans Affairs Medical Center 2011 - 2012
- A Novel Mouse Model of Podocyte Injury awarded by National Institutes of Health 2009 - 2012
- Molecular mechanisms of altered calcium sensing in human parathyroid disease awarded by National Institutes of Health 2010 - 2012
- Regulation of Podocyte Function by Angiotensin II awarded by National Institutes of Health 2004 - 2008
- G-Protein Coupled Receptor Kinases in Osteogenesis awarded by National Institutes of Health 2001 - 2006
- Pharmacologically Induced Neo-osteogenesis awarded by National Institutes of Health 1986 - 2004
- Thromboxane Receptor Regulation By Protein Kinases awarded by National Institutes of Health 1995 - 2000
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Hall, Gentzon, Liming Wang, and Robert F. Spurney. “TRPC Channels in Proteinuric Kidney Diseases.” Cells 9, no. 1 (December 23, 2019). https://doi.org/10.3390/cells9010044.
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  - Wang, Liming, Jae-Hyung Chang, Anne F. Buckley, and Robert F. Spurney. “Knockout of TRPC6 promotes insulin resistance and exacerbates glomerular injury in Akita mice.” Kidney International 95, no. 2 (February 2019): 321–32. https://doi.org/10.1016/j.kint.2018.09.026.
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  - Wang, Liming, Anne F. Buckley, and Robert F. Spurney. “Regulation of cofilin phosphorylation in glomerular podocytes by testis specific kinase 1 (TESK1).” Sci Rep 8, no. 1 (August 16, 2018): 12286. https://doi.org/10.1038/s41598-018-30115-3.
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  - Hall, Gentzon, Brandon M. Lane, Kamal Khan, Igor Pediaditakis, Jianqiu Xiao, Guanghong Wu, Liming Wang, et al. “The Human FSGS-Causing ANLN R431C Mutation Induces Dysregulated PI3K/AKT/mTOR/Rac1 Signaling in Podocytes.” J Am Soc Nephrol 29, no. 8 (August 2018): 2110–22. https://doi.org/10.1681/ASN.2017121338.
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  - Hall, Gentzon, and Robert F. Spurney. “Losing their footing: Rac1 signaling causes podocyte detachment and FSGS.” Kidney Int 92, no. 2 (August 2017): 283–85. https://doi.org/10.1016/j.kint.2017.03.045.
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  - Wang, Liming, Yonggang Sha, Jingyi Bai, William Eisner, Matthew A. Sparks, Anne F. Buckley, and Robert F. Spurney. “Podocyte-specific knockout of cyclooxygenase 2 exacerbates diabetic kidney disease.” Am J Physiol Renal Physiol 313, no. 2 (August 1, 2017): F430–39. https://doi.org/10.1152/ajprenal.00614.2016.
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  - Johnson, Stacy A., and Robert F. Spurney. “Twenty years after ACEIs and ARBs: emerging treatment strategies for diabetic nephropathy.” Am J Physiol Renal Physiol 309, no. 10 (November 15, 2015): F807–20. https://doi.org/10.1152/ajprenal.00266.2015.
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  - Wang, Liming, Grant Jirka, Paul B. Rosenberg, Anne F. Buckley, Jose A. Gomez, Timothy A. Fields, Michelle P. Winn, and Robert F. Spurney. “Gq signaling causes glomerular injury by activating TRPC6.” J Clin Invest 125, no. 5 (May 2015): 1913–26. https://doi.org/10.1172/JCI76767.
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  - Hall, Gentzon, Rasheed A. Gbadegesin, Peter Lavin, Guanghong Wu, Yangfan Liu, Edwin C. Oh, Liming Wang, et al. “A novel missense mutation of Wilms' Tumor 1 causes autosomal dominant FSGS.” J Am Soc Nephrol 26, no. 4 (April 2015): 831–43. https://doi.org/10.1681/ASN.2013101053.
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  - Gbadegesin, Rasheed A., Gentzon Hall, Adebowale Adeyemo, Nils Hanke, Irini Tossidou, James Burchette, Guanghong Wu, et al. “Mutations in the gene that encodes the F-actin binding protein anillin cause FSGS.” J Am Soc Nephrol 25, no. 9 (September 2014): 1991–2002. https://doi.org/10.1681/ASN.2013090976.
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  - Hall, Gentzon, Janelle Rowell, Federica Farinelli, Rasheed A. Gbadegesin, Peter Lavin, Guanghong Wu, Alison Homstad, et al. “Phosphodiesterase 5 inhibition ameliorates angiontensin II-induced podocyte dysmotility via the protein kinase G-mediated downregulation of TRPC6 activity.” Am J Physiol Renal Physiol 306, no. 12 (June 15, 2014): F1442–50. https://doi.org/10.1152/ajprenal.00212.2013.
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  - Ortiz-Melo, David I., and Robert F. Spurney. “Special deLIVERy: podocyte injury promotes renal angiotensin II generation from liver-derived angiotensinogen.” Kidney Int 85, no. 5 (May 2014): 1009–11. https://doi.org/10.1038/ki.2013.440.
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  - Wang, Liming, Yuping Tang, William Eisner, Matthew A. Sparks, Anne F. Buckley, and Robert F. Spurney. “Augmenting podocyte injury promotes advanced diabetic kidney disease in Akita mice.” Biochem Biophys Res Commun 444, no. 4 (February 21, 2014): 622–27. https://doi.org/10.1016/j.bbrc.2014.01.115.
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  - Spurney, Robert Frank. “Non-immunologic actions of calcineurin inhibitors in proteinuric kidney diseases.” Front Endocrinol (Lausanne) 5 (2014): 181. https://doi.org/10.3389/fendo.2014.00181.
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  - Wang, L., T. A. Fields, K. Pazmino, Q. Dai, J. L. Burchette, D. N. Howell, T. M. Coffman, and R. F. Spurney. “Erratum: Activation of Gaq-coupled signaling pathways in glomerular podocytes promotes renal injury (Journal of the American Society of Nephrology (2005) 16 (3611-3622)).” Journal of the American Society of Nephrology 24, no. 12 (December 9, 2013): 2126. https://doi.org/10.1681/ASN.2013080868.
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  - Wang, Xiaojuan, Shaoxi Liao, Erik R. Nelson, Robert Schmalzigaug, Robert F. Spurney, Farshid Guilak, Richard T. Premont, and Diane Gesty-Palmer. “The cytoskeletal regulatory scaffold protein GIT2 modulates mesenchymal stem cell differentiation and osteoblastogenesis.” Biochem Biophys Res Commun 425, no. 2 (August 24, 2012): 407–12. https://doi.org/10.1016/j.bbrc.2012.07.111.
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  - Zhang, Jian-dong, Mehul B. Patel, Young-Soo Song, Robert Griffiths, James Burchette, Phillip Ruiz, Matthew A. Sparks, et al. “A novel role for type 1 angiotensin receptors on T lymphocytes to limit target organ damage in hypertension.” Circ Res 110, no. 12 (June 8, 2012): 1604–17. https://doi.org/10.1161/CIRCRESAHA.111.261768.
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  - Wang, Liming, Mathew J. Ellis, Jose A. Gomez, William Eisner, Walter Fennell, David N. Howell, Phillip Ruiz, Timothy A. Fields, and Robert F. Spurney. “Mechanisms of the proteinuria induced by Rho GTPases.” Kidney International 81, no. 11 (June 2012): 1075–85. https://doi.org/10.1038/ki.2011.472.
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  - Chang, Jae-Hyung, Seung-Yeol Paik, Lan Mao, William Eisner, Patrick J. Flannery, Liming Wang, Yuping Tang, et al. “Diabetic kidney disease in FVB/NJ Akita mice: temporal pattern of kidney injury and urinary nephrin excretion.” Plos One 7, no. 4 (2012): e33942. https://doi.org/10.1371/journal.pone.0033942.
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  - Wang, L., Y. Tang, D. N. Howell, P. Ruiz, and R. F. Spurney. “A novel mouse model of podocyte depletion.” Nephron Exp Nephrol 121, no. 1–2 (2012): e10–22. https://doi.org/10.1159/000342369.
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  - Wang, Liming, Jae-Hyung Chang, Seung-Yeol Paik, Yuping Tang, William Eisner, and Robert F. Spurney. “Calcineurin (CN) activation promotes apoptosis of glomerular podocytes both in vitro and in vivo.” Mol Endocrinol 25, no. 8 (August 2011): 1376–86. https://doi.org/10.1210/me.2011-0029.
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  - Koh, James, Moahad Dar, Brian R. Untch, Darshana Dixit, Yuhong Shi, Zhao Yang, Mohamed Abdelgadir Adam, et al. “Regulator of G protein signaling 5 is highly expressed in parathyroid tumors and inhibits signaling by the calcium-sensing receptor.” Mol Endocrinol 25, no. 5 (May 2011): 867–76. https://doi.org/10.1210/me.2010-0277.
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  - Gesty-Palmer, Diane, Pat Flannery, Ling Yuan, Leonor Corsino, Robert Spurney, Robert J. Lefkowitz, and Louis M. Luttrell. “A beta-arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation.” Sci Transl Med 1, no. 1 (October 7, 2009): 1ra1. https://doi.org/10.1126/scitranslmed.3000071.
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  - Wang, Liming, Diane Gesty-Palmer, Timothy A. Fields, and Robert F. Spurney. “Inhibition of WNT signaling by G protein-coupled receptor (GPCR) kinase 2 (GRK2).” Mol Endocrinol 23, no. 9 (September 2009): 1455–65. https://doi.org/10.1210/me.2009-0084.
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  - Spurney, Robert F., and Thomas M. Coffman. “Stressed-out podocytes in diabetes?” J Am Soc Nephrol 19, no. 11 (November 2008): 2035–37. https://doi.org/10.1681/ASN.2008090955.
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  - Wang, Liming, Patrick J. Flannery, Paul B. Rosenberg, Timothy A. Fields, and Robert F. Spurney. “Gq-dependent signaling upregulates COX2 in glomerular podocytes.” J Am Soc Nephrol 19, no. 11 (November 2008): 2108–18. https://doi.org/10.1681/ASN.2008010113.
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  - Wang, Liming, Mathew J. Ellis, Timothy A. Fields, David N. Howell, and Robert F. Spurney. “Beneficial effects of the Rho kinase inhibitor Y27632 in murine puromycin aminonucleoside nephrosis.” Kidney & Blood Pressure Research 31, no. 2 (January 2008): 111–21. https://doi.org/10.1159/000121531.
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  - Wang, Liming, Patrick J. Flannery, Krairerk Athirakul, Stephen R. Dunn, Wissam M. Kourany, and Robert F. Spurney. “Galphaq-dependent signaling cascades stimulate water-seeking behavior.” Am J Physiol Renal Physiol 291, no. 4 (October 2006): F781–89. https://doi.org/10.1152/ajprenal.00401.2005.
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  - Gesty-Palmer, Diane, Minyong Chen, Eric Reiter, Seungkirl Ahn, Christopher D. Nelson, Shuntai Wang, Allen E. Eckhardt, et al. “Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation.” J Biol Chem 281, no. 16 (April 21, 2006): 10856–64. https://doi.org/10.1074/jbc.M513380200.
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  - Winn, Michelle P., Nikki Daskalakis, Robert F. Spurney, and John P. Middleton. “Unexpected role of TRPC6 channel in familial nephrotic syndrome: does it have clinical implications?” J Am Soc Nephrol 17, no. 2 (February 2006): 378–87. https://doi.org/10.1681/ASN.2005090962.
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  - Flannery, Patrick J., and Robert F. Spurney. “Transactivation of the epidermal growth factor receptor by angiotensin II in glomerular podocytes.” Nephron Exp Nephrol 103, no. 3 (2006): e109–18. https://doi.org/10.1159/000092196.
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  - Tanenbaum, N. D., D. N. Howell, J. P. Middleton, and R. F. Spurney. “Lambda light chain deposition disease in a renal allograft.” Transplant Proc 37, no. 10 (December 2005): 4289–92. https://doi.org/10.1016/j.transproceed.2005.10.030.
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  - Wang, Liming, Timothy A. Fields, Kathy Pazmino, Qunsheng Dai, James L. Burchette, David N. Howell, Thomas M. Coffman, and Robert F. Spurney. “Activation of Galpha q-coupled signaling pathways in glomerular podocytes promotes renal injury.” J Am Soc Nephrol 16, no. 12 (December 2005): 3611–22. https://doi.org/10.1681/ASN.2005020167.
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  - Rocha, Paulo N., Troy J. Plumb, Lisa A. Robinson, Robert Spurney, David Pisetsky, Beverly H. Koller, and Thomas M. Coffman. “Role of thromboxane A2 in the induction of apoptosis of immature thymocytes by lipopolysaccharide.” Clin Diagn Lab Immunol 12, no. 8 (August 2005): 896–903. https://doi.org/10.1128/CDLI.12.8.896-903.2005.
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  - Crowley, Steven D., Susan B. Gurley, Michael I. Oliverio, A Kathy Pazmino, Robert Griffiths, Patrick J. Flannery, Robert F. Spurney, et al. “Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system.” J Clin Invest 115, no. 4 (April 2005): 1092–99. https://doi.org/10.1172/JCI23378.
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  - Pi, Min, Robert H. Oakley, Diane Gesty-Palmer, Rachael D. Cruickshank, Robert F. Spurney, Louis M. Luttrell, and L Darryl Quarles. “Beta-arrestin- and G protein receptor kinase-mediated calcium-sensing receptor desensitization.” Mol Endocrinol 19, no. 4 (April 2005): 1078–87. https://doi.org/10.1210/me.2004-0450.
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  - Wang, Liming, Shiguang Liu, L Darryl Quarles, and Robert F. Spurney. “Targeted overexpression of G protein-coupled receptor kinase-2 in osteoblasts promotes bone loss.” Am J Physiol Endocrinol Metab 288, no. 4 (April 2005): E826–34. https://doi.org/10.1152/ajpendo.00422.2004.
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  - Wang, Liming, L Darryl Quarles, and Robert F. Spurney. “Unmasking the osteoinductive effects of a G-protein-coupled receptor (GPCR) kinase (GRK) inhibitor by treatment with PTH(1-34).” J Bone Miner Res 19, no. 10 (October 2004): 1661–70. https://doi.org/10.1359/JBMR.040708.
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  - Thomas, Dennis W., Paulo N. Rocha, Chandra Nataraj, Lisa A. Robinson, Robert F. Spurney, Beverly H. Koller, and Thomas M. Coffman. “Proinflammatory actions of thromboxane receptors to enhance cellular immune responses.” J Immunol 171, no. 12 (December 15, 2003): 6389–95. https://doi.org/10.4049/jimmunol.171.12.6389.
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  - Wang, Liming, Patrick J. Flannery, and Robert F. Spurney. “Characterization of angiotensin II-receptor subtypes in podocytes.” J Lab Clin Med 142, no. 5 (November 2003): 313–21. https://doi.org/10.1016/S0022-2143(03)00139-2.
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  - Le, Thu H., Hyung-Suk Kim, Andrew M. Allen, Robert F. Spurney, Oliver Smithies, and Thomas M. Coffman. “Physiological impact of increased expression of the AT1 angiotensin receptor.” Hypertension 42, no. 4 (October 2003): 507–14. https://doi.org/10.1161/01.HYP.0000092000.07559.57.
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  - Spurney, R. F. “Regulated expression of G protein-coupled receptor kinases (GRK's) and beta-arrestins in osteoblasts.” Calcif Tissue Int 73, no. 2 (August 2003): 153–60. https://doi.org/10.1007/s00223-002-1018-5.
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  - Tharaux, Pierre-Louis, Richard C. Bukoski, Paulo N. Rocha, Steven D. Crowley, Phillip Ruiz, Chandra Nataraj, David N. Howell, Kozo Kaibuchi, Robert F. Spurney, and Thomas M. Coffman. “Rho kinase promotes alloimmune responses by regulating the proliferation and structure of T cells.” J Immunol 171, no. 1 (July 1, 2003): 96–105. https://doi.org/10.4049/jimmunol.171.1.96.
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  - Pi, Min, Robert F. Spurney, Qisheng Tu, Todd Hinson, and L Darryl Quarles. “Calcium-sensing receptor activation of rho involves filamin and rho-guanine nucleotide exchange factor.” Endocrinology 143, no. 10 (October 2002): 3830–38. https://doi.org/10.1210/en.2002-220240.
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  - Flannery, Patrick J., and Robert F. Spurney. “Desensitization of the mouse thromboxane A2 receptor (TP) by G protein-coupled receptor kinases (Grks).” Prostaglandins Other Lipid Mediat 70, no. 1–2 (September 2002): 79–90. https://doi.org/10.1016/s0090-6980(02)00013-8.
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  - Spurney, Robert F., Patrick J. Flannery, Sanford C. Garner, Krairerk Athirakul, Shiguang Liu, Farshid Guilak, and L Darryl Quarles. “Anabolic effects of a G protein-coupled receptor kinase inhibitor expressed in osteoblasts.” J Clin Invest 109, no. 10 (May 2002): 1361–71. https://doi.org/10.1172/JCI14663.
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  - Flannery, P. J., and R. F. Spurney. “Domains of the parathyroid hormone (PTH) receptor required for regulation by G protein-coupled receptor kinases (GRKs).” Biochem Pharmacol 62, no. 8 (October 15, 2001): 1047–58. https://doi.org/10.1016/s0006-2952(01)00749-3.
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  - Guo, R., S. Liu, R. F. Spurney, and L. D. Quarles. “Analysis of recombinant Phex: an endopeptidase in search of a substrate.” Am J Physiol Endocrinol Metab 281, no. 4 (October 2001): E837–47. https://doi.org/10.1152/ajpendo.2001.281.4.E837.
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  - Spurney, R. F. “Regulation of thromboxane receptor (TP) phosphorylation by protein phosphatase 1 (PP1) and PP2A.” J Pharmacol Exp Ther 296, no. 2 (February 2001): 592–99.
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  - Butterly, D. W., R. F. Spurney, P. Ruiz, R. Griffiths, C. Albrightson, and T. M. Coffman. “A role for leukotrienes in cyclosporine nephrotoxicity.” Kidney Int 57, no. 6 (June 2000): 2586–93. https://doi.org/10.1046/j.1523-1755.2000.00118.x.
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  - Pi, M., S. C. Garner, P. Flannery, R. F. Spurney, and L. D. Quarles. “Sensing of extracellular cations in CasR-deficient osteoblasts. Evidence for a novel cation-sensing mechanism.” J Biol Chem 275, no. 5 (February 4, 2000): 3256–63. https://doi.org/10.1074/jbc.275.5.3256.
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  - Hall, R. A., R. F. Spurney, R. T. Premont, N. Rahman, J. T. Blitzer, J. A. Pitcher, and R. J. Lefkowitz. “G protein-coupled receptor kinase 6A phosphorylates the Na(+)/H(+) exchanger regulatory factor via a PDZ domain-mediated interaction.” J Biol Chem 274, no. 34 (August 20, 1999): 24328–34. https://doi.org/10.1074/jbc.274.34.24328.
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  - Goulet, J. L., R. C. Griffiths, P. Ruiz, R. F. Spurney, D. S. Pisetsky, B. H. Koller, and T. M. Coffman. “Deficiency of 5-lipoxygenase abolishes sex-related survival differences in MRL-lpr/lpr mice.” J Immunol 163, no. 1 (July 1, 1999): 359–66.
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  - Spurney, R. F., M. Pi, P. Flannery, and L. D. Quarles. “Aluminum is a weak agonist for the calcium-sensing receptor.” Kidney Int 55, no. 5 (May 1999): 1750–58. https://doi.org/10.1046/j.1523-1755.1999.00432.x.
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  - Spurney, R. F. “Role of C-terminal serines in desensitization and phosphorylation of the mouse thromboxane receptor.” J Biol Chem 273, no. 43 (October 23, 1998): 28496–503. https://doi.org/10.1074/jbc.273.43.28496.
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  - Weinman, E. J., D. Steplock, K. Tate, R. A. Hall, R. F. Spurney, and S. Shenolikar. “Structure-function of recombinant Na/H exchanger regulatory factor (NHE-RF).” J Clin Invest 101, no. 10 (May 15, 1998): 2199–2206. https://doi.org/10.1172/JCI204.
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  - Spurney, R. F. “Effect of receptor number on desensitization of the mouse thromboxane receptor.” Biochem Pharmacol 55, no. 8 (April 15, 1998): 1271–81. https://doi.org/10.1016/s0006-2952(97)00633-3.
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  - Spurney, R. F., and T. M. Coffman. “The C-terminus of the thromboxane receptor contributes to coupling and desensitization in a mouse mesangial cell line.” J Pharmacol Exp Ther 283, no. 1 (October 1997): 207–15.
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  - Hartle, J. E., V. Prpic, S. R. Siddhanti, R. F. Spurney, and L. D. Quarles. “Differential regulation of receptor-stimulated cyclic adenosine monophosphate production by polyvalent cations in MC3T3-E1 osteoblasts.” J Bone Miner Res 11, no. 6 (June 1996): 789–99. https://doi.org/10.1002/jbmr.5650110610.
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  - Best, V., P. Ruiz, and R. F. Spurney. “The Prostaglandin E(1) (PGE(1)) Analog Misoprostol Ameliorates Autoimmune Disease and Depletes T Lymphocytes in MRL-lpr/lpr Mice.” Am J Ther 2, no. 12 (December 1995): 943–48. https://doi.org/10.1097/00045391-199512000-00007.
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  - Butterly, D. W., R. F. Spurney, P. Ruiz, E. Pirotzky, P. Braquet, and T. M. Coffman. “Role of platelet activating factor in kidney transplant rejection in the rat.” Kidney Int 48, no. 2 (August 1995): 337–43. https://doi.org/10.1038/ki.1995.301.
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  - Garnovskaya, M. N., C. G. Nebigil, J. M. Arthur, R. F. Spurney, and J. R. Raymond. “5-Hydroxytryptamine2A receptors expressed in rat renal mesangial cells inhibit cyclic AMP accumulation.” Mol Pharmacol 48, no. 2 (August 1995): 230–37.
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  - Fan, P. Y., P. Ruiz, D. S. Pisetsky, and R. F. Spurney. “The effects of short-term treatment with the prostaglandin E1 (PGE1) analog misoprostol on inflammatory mediator production in murine lupus nephritis.” Clin Immunol Immunopathol 75, no. 2 (May 1995): 125–30. https://doi.org/10.1006/clin.1995.1061.
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  - Nebigil, C. G., M. N. Garnovskaya, R. F. Spurney, and J. R. Raymond. “Identification of a rat glomerular mesangial cell mitogenic 5-HT2A receptor.” American Journal of Physiology Renal Fluid and Electrolyte Physiology 268, no. 1 37-1 (January 1, 1995).
  - Nebigil, C. G., M. N. Garnovskaya, R. F. Spurney, and J. R. Raymond. “Identification of a rat glomerular mesangial cell mitogenic 5-HT2A receptor.” Am J Physiol 268, no. 1 Pt 2 (January 1995): F122–27. https://doi.org/10.1152/ajprenal.1995.268.1.F122.
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  - Spurney, R. F., P. Ruiz, C. R. Albrightson, D. S. Pisetsky, and T. M. Coffman. “Fish oil feeding modulates leukotriene production in murine lupus nephritis.” Prostaglandins 48, no. 5 (November 1994): 331–48. https://doi.org/10.1016/0090-6980(94)90032-9.
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  - SPURNEY, R. F., J. P. MIDDLETON, J. R. RAYMOND, and T. M. COFFMAN. “MODULATION OF THROMBOXANE RECEPTOR ACTIVATION IN RAT GLOMERULAR MESANGIAL CELLS.” American Journal of Physiology 267, no. 3 (September 1, 1994): F467–78.
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  - Spurney, R. F., J. P. Middleton, J. R. Raymond, and T. M. Coffman. “Modulation of thromboxane receptor activation in rat glomerular mesangial cells.” Am J Physiol 267, no. 3 Pt 2 (September 1994): F467–78. https://doi.org/10.1152/ajprenal.1994.267.3.F467.
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  - GILKESON, G. S., D. S. PISETSKY, T. M. COFFMAN, R. F. SPURNEY, C. BEST, and J. B. WEINBERG. “CHRONIC BLOCKAGE OF NITRIC-OXIDE OVERPRODUCTION IN MRL-LPR MICE BY ORAL N(G) MONOMETHYL L-ARGININE (NMMA) PREVENTS INFLAMMATORY RENAL-DISEASE AND ENHANCES RENAL BLOOD-FLOW.” Clinical Research 42, no. 2 (April 1, 1994): A139–A139.
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  - Spurney, R. F., S. Ibrahim, D. Butterly, P. E. Klotman, F. Sanfilippo, and T. M. Coffman. “Leukotrienes in renal transplant rejection in rats. Distinct roles for leukotriene B4 and peptidoleukotrienes in the pathogenesis of allograft injury.” J Immunol 152, no. 2 (January 15, 1994): 867–76.
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  - Spurney, R. F., J. P. Middleton, J. R. Raymond, and T. M. Coffman. “Modulation of thromboxane receptor activation in rat glomerular mesangial cells.” Am.J.Physiol. 267, no. 3 part 2 (January 1, 1994).
  - Coffman, T., S. Geier, S. Ibrahim, R. Griffiths, R. Spurney, O. Smithies, B. Koller, and F. Sanfilippo. “Improved renal function in mouse kidney allografts lacking MHC class I antigens.” J Immunol 151, no. 1 (July 1, 1993): 425–35.
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  - Spurney, R. F., J. J. Onorato, F. J. Albers, and T. M. Coffman. “Thromboxane binding and signal transduction in rat glomerular mesangial cells.” Am J Physiol 264, no. 2 Pt 2 (February 1993): F292–99. https://doi.org/10.1152/ajprenal.1993.264.2.F292.
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  - Spurney, R. F., J. J. Onorato, P. Ruiz, D. S. Pisetsky, and T. M. Coffman. “Characterization of glomerular thromboxane receptors in murine lupus nephritis.” J Pharmacol Exp Ther 264, no. 2 (February 1993): 584–90.
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  - Ruiz, P., L. Rey, R. Spurney, T. Coffman, and A. Viciana. “Thromboxane augmentation of alloreactive T cell function.” Transplantation 54, no. 3 (September 1992): 498–505. https://doi.org/10.1097/00007890-199209000-00021.
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  - Gilkeson, G. S., R. Spurney, T. M. Coffman, R. Kurlander, P. Ruiz, and D. S. Pisetsky. “Effect of anti-CD4 antibody treatment on inflammatory arthritis in MRL-lpr/lpr mice.” Clin Immunol Immunopathol 64, no. 2 (August 1992): 166–72. https://doi.org/10.1016/0090-1229(92)90195-t.
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  - Spurney, R. F., P. Y. Fan, P. Ruiz, F. Sanfilippo, D. S. Pisetsky, and T. M. Coffman. “Thromboxane receptor blockade reduces renal injury in murine lupus nephritis.” Kidney Int 41, no. 4 (April 1992): 973–82. https://doi.org/10.1038/ki.1992.149.
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  - Spurney, R. F., R. J. Bernstein, P. Ruiz, D. S. Pisetsky, and T. M. Coffman. “Physiologic role for enhanced renal thromboxane production in murine lupus nephritis.” Prostaglandins 42, no. 1 (July 1991): 15–28. https://doi.org/10.1016/0090-6980(91)90090-3.
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  - Spurney, R. F., P. Ruiz, D. S. Pisetsky, and T. M. Coffman. “Enhanced renal leukotriene production in murine lupus: role of lipoxygenase metabolites.” Kidney Int 39, no. 1 (January 1991): 95–102. https://doi.org/10.1038/ki.1991.12.
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  - Spurney, R. F., W. J. Fulkerson, and S. J. Schwab. “Acute renal failure in critically ill patients: prognosis for recovery of kidney function after prolonged dialysis support.” Crit Care Med 19, no. 1 (January 1991): 8–11. https://doi.org/10.1097/00003246-199101000-00007.
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  - Spurney, R. F., S. D. Mayros, D. Collins, P. Ruiz, P. E. Klotman, and T. Coffman. “Thromboxane receptor blockade improves cyclosporine nephrotoxicity in rats.” Prostaglandins 39, no. 2 (February 1990): 135–46. https://doi.org/10.1016/0090-6980(90)90070-c.
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  - Spurney, R. F., and K. M. McCormack. “Immature omental teratoma.” Arch Pathol Lab Med 111, no. 8 (August 1987): 762–64.
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- Conference Papers
  - Hall, Gentzon, G Michelle Ducasa, Brandon M. Lane, Max Lagas, Maria E. Kovalik, Olivia G. Gregory, Guanghong Wu, et al. “THE LMX1 beta R246Q MUTATION INDUCES PODOCYTE INJURY THROUGH DYSREGULATION OF CHOLESTEROL TRANSPORT GENE EXPRESSION.” In Nephrology Dialysis Transplantation, Vol. 34. OXFORD UNIV PRESS, 2019.
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  - Hall, Gentzon, Sidharth K. Sethi, Brandon M. Lane, Matthew G. Sampson, Olivia G. Gregory, Maria E. Kovalik, Megan Chryst-Stangl, et al. “A NOVEL HETEROZYGOUS MISSENSE MUTATION OF WILMS' TUMOR 1 MAY CAUSE FSGS THROUGH DYSREGULATED EXPRESSION OF ARHGAP24.” In Nephrology Dialysis Transplantation, Vol. 34. OXFORD UNIV PRESS, 2019.
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  - Gesty-Palmer, D., R. F. Spurney, P. J. Flannery, and L. Yuan. “The PTH 1 receptor (PTH1R) Stimulates Bone Formation Through a Distinct beta-Arrestin Dependent Pathway Independent of G Protein Activation.” In Journal of Bone and Mineral Research, 23:S64–S64. AMER SOC BONE & MINERAL RES, 2008.
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  - Wang, L., and R. F. Spurney. “G protein-coupled receptor (GPCR) kinase 2 (GRK2) inhibits canonical Wnt signaling.” In Journal of Bone and Mineral Research, 21:S99–S99. AMER SOC BONE & MINERAL RES, 2006.
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  - Gesty-Palmer, D., E. Reiter, R. F. Spurney, L. M. Luttrell, and R. J. Lefkowitz. “Distinct conformations of the parathyroid hormone receptor mediate G protein and beta-arrestin dependent activation of ERK1/2.” In Journal of Bone and Mineral Research, 20:S182–S182. AMER SOC BONE & MINERAL RES, 2005.
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  - Wang, L., and R. F. Spurney. “Enhanced bone mass in mice lacking G protein-coupled receptor kinases.” In Journal of Bone and Mineral Research, 20:S79–S79. AMER SOC BONE & MINERAL RES, 2005.
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  - Wang, L., P. Flannery, and R. F. Spurney. “Overexpression of g protein-coupled receptor kinase 2 (GRK2) in osteoblasts decreases bone mass and reduced the anabolic effects of PTH(1-34).” In Journal of Bone and Mineral Research, 19:S337–S337. AMER SOC BONE & MINERAL RES, 2004.
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  - Athirakul, K., A. J. Bradbury, J. Graves, L. Miller, J. X. Ma, L. Mao, H. Rockman, R. F. Spurney, T. M. Coffman, and D. C. Zeldin. “Hypertension in Cyp2j5 null mice is estrogen responsive.” In Journal of the American Society of Nephrology, 14:29A-29A. LIPPINCOTT WILLIAMS & WILKINS, 2003.
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  - Burnham, C. E., R. F. Spurney, L. G. Simpson, A. J. Urdaneta, and D. Quarles. “Mice transgenic for FSGS-linked mutant actinin-4 (ACTN4) express elevated renal EGR-1 mRNA.” In Journal of the American Society of Nephrology, 14:334A-334A. LIPPINCOTT WILLIAMS & WILKINS, 2003.
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  - Wang, L. M., H. David, and R. F. Spurney. “Activation of Gq-coupled signaling pathways in glomerular podocytes causes abnormalities in glomerular ultrastructure, albuminuria and reduces expression of nephrin mRNA.” In Journal of the American Society of Nephrology, 14:59A-59A. LIPPINCOTT WILLIAMS & WILKINS, 2003.
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  - Coffman, T. M., R. F. Spurney, R. B. Mannon, and R. Levenson. “Thromboxane (TX) stimulates plasminogen activator inhibitor-1 (PAI-1) production by mesangial cells.” In Journal of the American Society of Nephrology, 7:A1985–A1985. AMER SOC NEPHROLOGY, 1996.
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  - Spurney, R. F. “Role of C-terminal serines in agonist-induced desensitization of the mouse thromboxane A(2) (TxA(2)) receptor.” In Journal of the American Society of Nephrology, 7:A2200–A2200. AMER SOC NEPHROLOGY, 1996.
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  - SPURNEY, R. F. “THROMBOXANE A(2) (TXA(2)) RECEPTOR NUMBER MODULATES DESENSITIZATION, BUT NOT DOWN-REGULATION, IN SV40-TRANSFORMED MOUSE MESANGIAL CELLS.” In Journal of the American Society of Nephrology, 6:812–812. WILLIAMS & WILKINS, 1995.
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  - SPURNEY, R. F., and T. M. COFFMAN. “TRUNCATION OF THE CARBOXYL-TERMINUS OF THE THROMBOXANE A(2) (TXA(2)) RECEPTOR AFFECTS COUPLING AND DESENSITIZATION IN MOUSE MESANGIAL CELLS.” In Journal of the American Society of Nephrology, 6:761–761. WILLIAMS & WILKINS, 1995.
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  - HARTLE, J. E., V. PRPIC, S. R. SIDDHANTI, R. F. SPURNEY, and L. D. QUARLES. “FUNCTIONAL-CHARACTERIZATION OF A CATION SENSING MECHANISM IN OSTEOBLASTS.” In Journal of Bone and Mineral Research, 10:S303–S303. BLACKWELL SCIENCE PUBL INC CAMBRIDGE, 1995.
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  - COFFMAN, T. M., R. B. MANNON, V. BEST, and R. F. SPURNEY. “ISOLATION OF A GENOMIC CLONE THAT ENCODES A KIDNEY THROMBOXANE-A(2) (TXA(2)) RECEPTOR.” In Journal of the American Society of Nephrology, 5:678–678. WILLIAMS & WILKINS, 1994.
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  - SPURNEY, R. F., T. M. COFFMAN, and J. P. MIDDLETON. “THROMBOXANE-A(2)[TXA(2)] ACTIVATES PROTEIN KINASE-C-ALPHA, AND KINASE-C-DELTA IN RAT GLOMERULAR MESANGIAL CELLS.” In Journal of the American Society of Nephrology, 5:731–731. WILLIAMS & WILKINS, 1994.
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  - NEBIGIL, C., J. R. RAYMOND, R. F. SPURNEY, and M. GARNOVSKAYA. “MOLECULAR-CLONING AND MULTIPLE 2ND MESSENGER PATHWAYS OF A 5-HT(2)-RECEPTOR EXPRESSED IN RAT MESANGIAL CELLS.” In Faseb Journal, 8:A87–A87. FEDERATION AMER SOC EXP BIOL, 1994.
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