Robert Frank Spurney
Professor of Medicine
Dr. Spurney’s research has focused on the role of G protein coupled receptors (GPCRs) in regulating cellular physiology both in normal and disease states as well as the regulatory mechanisms that modulate GPCR responsiveness at the molecular level. These studies have centered on two major themes. The first investigates the role of GPCR signaling pathways in regulating podocyte function using cultured podocytes and transgenic animals models. The second area of research involves the role of GPCR kinases (GRKs) and arrestin scaffolding proteins in modulating GPCR signaling in bone forming osteoblasts using cultured osteoblast cell lines as well as genetically modified mice including transgenic models and knockout animals. The long-term goal of these studies is to identify novel therapeutic targets that may useful for treating disease processes such as glomerulonephritis and osteoporosis.
Please see the Duke Nephrology Division website for more detailed information.
Please see the Duke Nephrology Division website for more detailed information.
Current Appointments & Affiliations
- Professor of Medicine, Medicine, Nephrology, Medicine 2012
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 1983
Contact Information
- Box 103015, Duke University Medical Center, Durham, NC 27710
- Duke Box 103015, Durham, NC 27710
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spurn002@mc.duke.edu
(919) 684-9729
- Background
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Education, Training, & Certifications
- Fellow in Nephrology, Medicine, Duke University 1987 - 1990
- Senior Assistant Resident, Medicine, Duke University 1986 - 1987
- Resident in Pathology, Pathology, Duke University 1985 - 1986
- Medical Resident, Medicine, Duke University 1983 - 1985
- M.D., Ohio State University 1983
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Previous Appointments & Affiliations
- Associate Professor of Medicine, Medicine, Nephrology, Medicine 2003 - 2011
- Associate Professor of Medicine, Medicine, Nephrology, Medicine 1997 - 2003
- Assistant Professor of Medicine, Medicine, Nephrology, Medicine 1993 - 1997
- Assistant Clinical Professor of Medicine, Medicine, Nephrology, Medicine 1992 - 1993
- Associate in the Department of Medicine, Medicine, Clinical Science Departments 1990 - 1992
- Research
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Selected Grants
- A Novel Therapeutic Approach to Treat Focal Segmental Glomerulosclerosis (FSGS) R21 awarded by National Institutes of Health 2022 - 2024
- Duke Training Grant in Nephrology awarded by National Institutes of Health 1995 - 2023
- Promoting Podocyte Protective Natriuretic Peptide Signaling in Proteinuric Kidney Diseases awarded by Department of Defense 2019 - 2022
- The Role of Interleukin-15 Receptor-alpha Variants in the Pathogenesis of FSGS awarded by National Institutes of Health 2017 - 2022
- Transmission electron microscope (TEM) awarded by National Institutes of Health 2019 - 2021
- IPA - Liming Wang awarded by Durham Veterans Affairs Medical Center 2019
- IPA - Robert Griffiths awarded by Durham Veterans Affairs Medical Center 2019
- Targeting TRPC6 to treat focal segmental glomerulosclerosis (FSGS) awarded by Amgen, Inc. 2016 - 2019
- IPA extension - Cindy Chen awarded by Durham Veterans Affairs Medical Center 2019
- Functional and Phenotypic Characterization of a New FSGS Gene awarded by National Institutes of Health 2014 - 2019
- IPA extension - Liming Wang awarded by Durham Veterans Affairs Medical Center 2018 - 2019
- IPA - Cindy Chen awarded by Durham Veterans Affairs Medical Center 2018 - 2019
- Gene Discovery in Autosomal Dominant Focal Segmental Glomerulosclerosis awarded by National Institutes of Health 2012 - 2018
- Serial Block Face Scanning Electron Microscope awarded by National Institutes of Health 2016 - 2018
- The role of dendritic cell-mediated T cell activation in hypertension awarded by National Institutes of Health 2017
- Role of Gq Signaling in Promoting Podocyte Injury in Diabetes Mellitus awarded by National Institutes of Health 2011 - 2016
- IPA Extensioin - Wang awarded by Durham Veterans Affairs Medical Center 2013 - 2014
- IPA - Liming Wang awarded by Durham Veterans Affairs Medical Center 2011 - 2012
- A Novel Mouse Model of Podocyte Injury awarded by National Institutes of Health 2009 - 2012
- Molecular mechanisms of altered calcium sensing in human parathyroid disease awarded by National Institutes of Health 2010 - 2012
- Regulation of Podocyte Function by Angiotensin II awarded by National Institutes of Health 2004 - 2008
- G-Protein Coupled Receptor Kinases in Osteogenesis awarded by National Institutes of Health 2001 - 2006
- Pharmacologically Induced Neo-osteogenesis awarded by National Institutes of Health 1986 - 2004
- Thromboxane Receptor Regulation By Protein Kinases awarded by National Institutes of Health 1995 - 2000
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External Relationships
- Palatin Technologies
- none
- none
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Wang, Liming, Yuping Tang, Anne F. Buckley, and Robert F. Spurney. “Blockade of the natriuretic peptide clearance receptor attenuates proteinuria in a mouse model of focal segmental glomerulosclerosis.” Physiol Rep 9, no. 21 (November 2021): e15095. https://doi.org/10.14814/phy2.15095.Full Text Link to Item
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Ren, Jiafa, Yuemei Xu, Xiaohan Lu, Liming Wang, Shintaro Ide, Gentzon Hall, Tomokazu Souma, Jamie R. Privratsky, Robert F. Spurney, and Steven D. Crowley. “Twist1 in podocytes ameliorates podocyte injury and proteinuria by limiting CCL2-dependent macrophage infiltration.” Jci Insight 6, no. 15 (August 9, 2021). https://doi.org/10.1172/jci.insight.148109.Full Text Link to Item
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Lane, Brandon M., Susan Murray, Katherine Benson, Agnieszka Bierzynska, Megan Chryst-Stangl, Liming Wang, Guanghong Wu, et al. “A Rare Autosomal Dominant Variant in Regulator of Calcineurin Type 1 (RCAN1) Gene Confers Enhanced Calcineurin Activity and May Cause FSGS.” J Am Soc Nephrol 32, no. 7 (July 2021): 1682–95. https://doi.org/10.1681/ASN.2020081234.Full Text Link to Item
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Hall, Gentzon, Liming Wang, and Robert F. Spurney. “TRPC Channels in Proteinuric Kidney Diseases.” Cells 9, no. 1 (December 23, 2019). https://doi.org/10.3390/cells9010044.Full Text Link to Item
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Wang, Liming, Jae-Hyung Chang, Anne F. Buckley, and Robert F. Spurney. “Knockout of TRPC6 promotes insulin resistance and exacerbates glomerular injury in Akita mice.” Kidney Int 95, no. 2 (February 2019): 321–32. https://doi.org/10.1016/j.kint.2018.09.026.Full Text Link to Item
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Wang, Liming, Anne F. Buckley, and Robert F. Spurney. “Regulation of cofilin phosphorylation in glomerular podocytes by testis specific kinase 1 (TESK1).” Sci Rep 8, no. 1 (August 16, 2018): 12286. https://doi.org/10.1038/s41598-018-30115-3.Full Text Link to Item
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Hall, Gentzon, Brandon M. Lane, Kamal Khan, Igor Pediaditakis, Jianqiu Xiao, Guanghong Wu, Liming Wang, et al. “The Human FSGS-Causing ANLN R431C Mutation Induces Dysregulated PI3K/AKT/mTOR/Rac1 Signaling in Podocytes.” J Am Soc Nephrol 29, no. 8 (August 2018): 2110–22. https://doi.org/10.1681/ASN.2017121338.Full Text Link to Item
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Hall, Gentzon, and Robert F. Spurney. “Losing their footing: Rac1 signaling causes podocyte detachment and FSGS.” Kidney Int 92, no. 2 (August 2017): 283–85. https://doi.org/10.1016/j.kint.2017.03.045.Full Text Link to Item
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Wang, Liming, Yonggang Sha, Jingyi Bai, William Eisner, Matthew A. Sparks, Anne F. Buckley, and Robert F. Spurney. “Podocyte-specific knockout of cyclooxygenase 2 exacerbates diabetic kidney disease.” Am J Physiol Renal Physiol 313, no. 2 (August 1, 2017): F430–39. https://doi.org/10.1152/ajprenal.00614.2016.Full Text Link to Item
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Johnson, Stacy A., and Robert F. Spurney. “Twenty years after ACEIs and ARBs: emerging treatment strategies for diabetic nephropathy.” Am J Physiol Renal Physiol 309, no. 10 (November 15, 2015): F807–20. https://doi.org/10.1152/ajprenal.00266.2015.Full Text Link to Item
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Wang, Liming, Grant Jirka, Paul B. Rosenberg, Anne F. Buckley, Jose A. Gomez, Timothy A. Fields, Michelle P. Winn, and Robert F. Spurney. “Gq signaling causes glomerular injury by activating TRPC6.” J Clin Invest 125, no. 5 (May 2015): 1913–26. https://doi.org/10.1172/JCI76767.Full Text Link to Item
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Hall, Gentzon, Rasheed A. Gbadegesin, Peter Lavin, Guanghong Wu, Yangfan Liu, Edwin C. Oh, Liming Wang, et al. “A novel missense mutation of Wilms' Tumor 1 causes autosomal dominant FSGS.” J Am Soc Nephrol 26, no. 4 (April 2015): 831–43. https://doi.org/10.1681/ASN.2013101053.Full Text Link to Item
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Gbadegesin, Rasheed A., Gentzon Hall, Adebowale Adeyemo, Nils Hanke, Irini Tossidou, James Burchette, Guanghong Wu, et al. “Mutations in the gene that encodes the F-actin binding protein anillin cause FSGS.” J Am Soc Nephrol 25, no. 9 (September 2014): 1991–2002. https://doi.org/10.1681/ASN.2013090976.Full Text Link to Item
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Hall, Gentzon, Janelle Rowell, Federica Farinelli, Rasheed A. Gbadegesin, Peter Lavin, Guanghong Wu, Alison Homstad, et al. “Phosphodiesterase 5 inhibition ameliorates angiontensin II-induced podocyte dysmotility via the protein kinase G-mediated downregulation of TRPC6 activity.” Am J Physiol Renal Physiol 306, no. 12 (June 15, 2014): F1442–50. https://doi.org/10.1152/ajprenal.00212.2013.Full Text Link to Item
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Ortiz-Melo, David I., and Robert F. Spurney. “Special deLIVERy: podocyte injury promotes renal angiotensin II generation from liver-derived angiotensinogen.” Kidney Int 85, no. 5 (May 2014): 1009–11. https://doi.org/10.1038/ki.2013.440.Full Text Link to Item
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Wang, Liming, Yuping Tang, William Eisner, Matthew A. Sparks, Anne F. Buckley, and Robert F. Spurney. “Augmenting podocyte injury promotes advanced diabetic kidney disease in Akita mice.” Biochem Biophys Res Commun 444, no. 4 (February 21, 2014): 622–27. https://doi.org/10.1016/j.bbrc.2014.01.115.Full Text Link to Item
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Spurney, Robert Frank. “Non-immunologic actions of calcineurin inhibitors in proteinuric kidney diseases.” Front Endocrinol (Lausanne) 5 (2014): 181. https://doi.org/10.3389/fendo.2014.00181.Full Text Link to Item
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Wang, L., T. A. Fields, K. Pazmino, Q. Dai, J. L. Burchette, D. N. Howell, T. M. Coffman, and R. F. Spurney. “Erratum: Activation of Gaq-coupled signaling pathways in glomerular podocytes promotes renal injury (Journal of the American Society of Nephrology (2005) 16 (3611-3622)).” Journal of the American Society of Nephrology 24, no. 12 (December 9, 2013): 2126. https://doi.org/10.1681/ASN.2013080868.Full Text
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Wang, Xiaojuan, Shaoxi Liao, Erik R. Nelson, Robert Schmalzigaug, Robert F. Spurney, Farshid Guilak, Richard T. Premont, and Diane Gesty-Palmer. “The cytoskeletal regulatory scaffold protein GIT2 modulates mesenchymal stem cell differentiation and osteoblastogenesis.” Biochem Biophys Res Commun 425, no. 2 (August 24, 2012): 407–12. https://doi.org/10.1016/j.bbrc.2012.07.111.Full Text Link to Item
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Zhang, Jian-dong, Mehul B. Patel, Young-Soo Song, Robert Griffiths, James Burchette, Phillip Ruiz, Matthew A. Sparks, et al. “A novel role for type 1 angiotensin receptors on T lymphocytes to limit target organ damage in hypertension.” Circ Res 110, no. 12 (June 8, 2012): 1604–17. https://doi.org/10.1161/CIRCRESAHA.111.261768.Full Text Link to Item
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Wang, Liming, Mathew J. Ellis, Jose A. Gomez, William Eisner, Walter Fennell, David N. Howell, Phillip Ruiz, Timothy A. Fields, and Robert F. Spurney. “Mechanisms of the proteinuria induced by Rho GTPases.” Kidney Int 81, no. 11 (June 2012): 1075–85. https://doi.org/10.1038/ki.2011.472.Full Text Link to Item
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Chang, Jae-Hyung, Seung-Yeol Paik, Lan Mao, William Eisner, Patrick J. Flannery, Liming Wang, Yuping Tang, et al. “Diabetic kidney disease in FVB/NJ Akita mice: temporal pattern of kidney injury and urinary nephrin excretion.” Plos One 7, no. 4 (2012): e33942. https://doi.org/10.1371/journal.pone.0033942.Full Text Link to Item
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Wang, L., Y. Tang, D. N. Howell, P. Ruiz, and R. F. Spurney. “A novel mouse model of podocyte depletion.” Nephron Exp Nephrol 121, no. 1–2 (2012): e10–22. https://doi.org/10.1159/000342369.Full Text Link to Item
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Wang, Liming, Jae-Hyung Chang, Seung-Yeol Paik, Yuping Tang, William Eisner, and Robert F. Spurney. “Calcineurin (CN) activation promotes apoptosis of glomerular podocytes both in vitro and in vivo.” Mol Endocrinol 25, no. 8 (August 2011): 1376–86. https://doi.org/10.1210/me.2011-0029.Full Text Link to Item
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Koh, James, Moahad Dar, Brian R. Untch, Darshana Dixit, Yuhong Shi, Zhao Yang, Mohamed Abdelgadir Adam, et al. “Regulator of G protein signaling 5 is highly expressed in parathyroid tumors and inhibits signaling by the calcium-sensing receptor.” Mol Endocrinol 25, no. 5 (May 2011): 867–76. https://doi.org/10.1210/me.2010-0277.Full Text Link to Item
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Gesty-Palmer, Diane, Pat Flannery, Ling Yuan, Leonor Corsino, Robert Spurney, Robert J. Lefkowitz, and Louis M. Luttrell. “A beta-arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation.” Sci Transl Med 1, no. 1 (October 7, 2009): 1ra1. https://doi.org/10.1126/scitranslmed.3000071.Full Text Link to Item
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Wang, Liming, Diane Gesty-Palmer, Timothy A. Fields, and Robert F. Spurney. “Inhibition of WNT signaling by G protein-coupled receptor (GPCR) kinase 2 (GRK2).” Mol Endocrinol 23, no. 9 (September 2009): 1455–65. https://doi.org/10.1210/me.2009-0084.Full Text Link to Item
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Spurney, Robert F., and Thomas M. Coffman. “Stressed-out podocytes in diabetes?” J Am Soc Nephrol 19, no. 11 (November 2008): 2035–37. https://doi.org/10.1681/ASN.2008090955.Full Text Link to Item
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Wang, Liming, Patrick J. Flannery, Paul B. Rosenberg, Timothy A. Fields, and Robert F. Spurney. “Gq-dependent signaling upregulates COX2 in glomerular podocytes.” J Am Soc Nephrol 19, no. 11 (November 2008): 2108–18. https://doi.org/10.1681/ASN.2008010113.Full Text Link to Item
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Wang, Liming, Mathew J. Ellis, Timothy A. Fields, David N. Howell, and Robert F. Spurney. “Beneficial effects of the Rho kinase inhibitor Y27632 in murine puromycin aminonucleoside nephrosis.” Kidney Blood Press Res 31, no. 2 (2008): 111–21. https://doi.org/10.1159/000121531.Full Text Link to Item
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Wang, Liming, Patrick J. Flannery, Krairerk Athirakul, Stephen R. Dunn, Wissam M. Kourany, and Robert F. Spurney. “Galphaq-dependent signaling cascades stimulate water-seeking behavior.” Am J Physiol Renal Physiol 291, no. 4 (October 2006): F781–89. https://doi.org/10.1152/ajprenal.00401.2005.Full Text Link to Item
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Gesty-Palmer, Diane, Minyong Chen, Eric Reiter, Seungkirl Ahn, Christopher D. Nelson, Shuntai Wang, Allen E. Eckhardt, et al. “Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation.” J Biol Chem 281, no. 16 (April 21, 2006): 10856–64. https://doi.org/10.1074/jbc.M513380200.Full Text Link to Item
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Winn, Michelle P., Nikki Daskalakis, Robert F. Spurney, and John P. Middleton. “Unexpected role of TRPC6 channel in familial nephrotic syndrome: does it have clinical implications?” J Am Soc Nephrol 17, no. 2 (February 2006): 378–87. https://doi.org/10.1681/ASN.2005090962.Full Text Link to Item
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Flannery, Patrick J., and Robert F. Spurney. “Transactivation of the epidermal growth factor receptor by angiotensin II in glomerular podocytes.” Nephron Exp Nephrol 103, no. 3 (2006): e109–18. https://doi.org/10.1159/000092196.Full Text Link to Item
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Tanenbaum, N. D., D. N. Howell, J. P. Middleton, and R. F. Spurney. “Lambda light chain deposition disease in a renal allograft.” Transplant Proc 37, no. 10 (December 2005): 4289–92. https://doi.org/10.1016/j.transproceed.2005.10.030.Full Text Link to Item
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Wang, Liming, Timothy A. Fields, Kathy Pazmino, Qunsheng Dai, James L. Burchette, David N. Howell, Thomas M. Coffman, and Robert F. Spurney. “Activation of Galpha q-coupled signaling pathways in glomerular podocytes promotes renal injury.” J Am Soc Nephrol 16, no. 12 (December 2005): 3611–22. https://doi.org/10.1681/ASN.2005020167.Full Text Link to Item
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Rocha, Paulo N., Troy J. Plumb, Lisa A. Robinson, Robert Spurney, David Pisetsky, Beverly H. Koller, and Thomas M. Coffman. “Role of thromboxane A2 in the induction of apoptosis of immature thymocytes by lipopolysaccharide.” Clin Diagn Lab Immunol 12, no. 8 (August 2005): 896–903. https://doi.org/10.1128/CDLI.12.8.896-903.2005.Full Text Link to Item
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Wang, Liming, Shiguang Liu, L Darryl Quarles, and Robert F. Spurney. “Targeted overexpression of G protein-coupled receptor kinase-2 in osteoblasts promotes bone loss.” Am J Physiol Endocrinol Metab 288, no. 4 (April 2005): E826–34. https://doi.org/10.1152/ajpendo.00422.2004.Full Text Link to Item
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Crowley, Steven D., Susan B. Gurley, Michael I. Oliverio, A Kathy Pazmino, Robert Griffiths, Patrick J. Flannery, Robert F. Spurney, et al. “Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system.” J Clin Invest 115, no. 4 (April 2005): 1092–99. https://doi.org/10.1172/JCI23378.Full Text Link to Item
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Pi, Min, Robert H. Oakley, Diane Gesty-Palmer, Rachael D. Cruickshank, Robert F. Spurney, Louis M. Luttrell, and L Darryl Quarles. “Beta-arrestin- and G protein receptor kinase-mediated calcium-sensing receptor desensitization.” Mol Endocrinol 19, no. 4 (April 2005): 1078–87. https://doi.org/10.1210/me.2004-0450.Full Text Link to Item
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Wang, Liming, L Darryl Quarles, and Robert F. Spurney. “Unmasking the osteoinductive effects of a G-protein-coupled receptor (GPCR) kinase (GRK) inhibitor by treatment with PTH(1-34).” J Bone Miner Res 19, no. 10 (October 2004): 1661–70. https://doi.org/10.1359/JBMR.040708.Full Text Link to Item
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Thomas, Dennis W., Paulo N. Rocha, Chandra Nataraj, Lisa A. Robinson, Robert F. Spurney, Beverly H. Koller, and Thomas M. Coffman. “Proinflammatory actions of thromboxane receptors to enhance cellular immune responses.” J Immunol 171, no. 12 (December 15, 2003): 6389–95. https://doi.org/10.4049/jimmunol.171.12.6389.Full Text Link to Item
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Wang, Liming, Patrick J. Flannery, and Robert F. Spurney. “Characterization of angiotensin II-receptor subtypes in podocytes.” J Lab Clin Med 142, no. 5 (November 2003): 313–21. https://doi.org/10.1016/S0022-2143(03)00139-2.Full Text Link to Item
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Le, Thu H., Hyung-Suk Kim, Andrew M. Allen, Robert F. Spurney, Oliver Smithies, and Thomas M. Coffman. “Physiological impact of increased expression of the AT1 angiotensin receptor.” Hypertension 42, no. 4 (October 2003): 507–14. https://doi.org/10.1161/01.HYP.0000092000.07559.57.Full Text Link to Item
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Spurney, R. F. “Regulated expression of G protein-coupled receptor kinases (GRK's) and beta-arrestins in osteoblasts.” Calcif Tissue Int 73, no. 2 (August 2003): 153–60. https://doi.org/10.1007/s00223-002-1018-5.Full Text Link to Item
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Tharaux, Pierre-Louis, Richard C. Bukoski, Paulo N. Rocha, Steven D. Crowley, Phillip Ruiz, Chandra Nataraj, David N. Howell, Kozo Kaibuchi, Robert F. Spurney, and Thomas M. Coffman. “Rho kinase promotes alloimmune responses by regulating the proliferation and structure of T cells.” J Immunol 171, no. 1 (July 1, 2003): 96–105. https://doi.org/10.4049/jimmunol.171.1.96.Full Text Link to Item
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Pi, Min, Robert F. Spurney, Qisheng Tu, Todd Hinson, and L Darryl Quarles. “Calcium-sensing receptor activation of rho involves filamin and rho-guanine nucleotide exchange factor.” Endocrinology 143, no. 10 (October 2002): 3830–38. https://doi.org/10.1210/en.2002-220240.Full Text Link to Item
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Flannery, Patrick J., and Robert F. Spurney. “Desensitization of the mouse thromboxane A2 receptor (TP) by G protein-coupled receptor kinases (Grks).” Prostaglandins Other Lipid Mediat 70, no. 1–2 (September 2002): 79–90. https://doi.org/10.1016/s0090-6980(02)00013-8.Full Text Link to Item
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Spurney, Robert F., Patrick J. Flannery, Sanford C. Garner, Krairerk Athirakul, Shiguang Liu, Farshid Guilak, and L Darryl Quarles. “Anabolic effects of a G protein-coupled receptor kinase inhibitor expressed in osteoblasts.” J Clin Invest 109, no. 10 (May 2002): 1361–71. https://doi.org/10.1172/JCI14663.Full Text Link to Item
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Flannery, P. J., and R. F. Spurney. “Domains of the parathyroid hormone (PTH) receptor required for regulation by G protein-coupled receptor kinases (GRKs).” Biochem Pharmacol 62, no. 8 (October 15, 2001): 1047–58. https://doi.org/10.1016/s0006-2952(01)00749-3.Full Text Link to Item
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Guo, R., S. Liu, R. F. Spurney, and L. D. Quarles. “Analysis of recombinant Phex: an endopeptidase in search of a substrate.” Am J Physiol Endocrinol Metab 281, no. 4 (October 2001): E837–47. https://doi.org/10.1152/ajpendo.2001.281.4.E837.Full Text Link to Item
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Spurney, R. F. “Regulation of thromboxane receptor (TP) phosphorylation by protein phosphatase 1 (PP1) and PP2A.” J Pharmacol Exp Ther 296, no. 2 (February 2001): 592–99.Link to Item
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Butterly, D. W., R. F. Spurney, P. Ruiz, R. Griffiths, C. Albrightson, and T. M. Coffman. “A role for leukotrienes in cyclosporine nephrotoxicity.” Kidney Int 57, no. 6 (June 2000): 2586–93. https://doi.org/10.1046/j.1523-1755.2000.00118.x.Full Text Link to Item
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Pi, M., S. C. Garner, P. Flannery, R. F. Spurney, and L. D. Quarles. “Sensing of extracellular cations in CasR-deficient osteoblasts. Evidence for a novel cation-sensing mechanism.” J Biol Chem 275, no. 5 (February 4, 2000): 3256–63. https://doi.org/10.1074/jbc.275.5.3256.Full Text Link to Item
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Hall, R. A., R. F. Spurney, R. T. Premont, N. Rahman, J. T. Blitzer, J. A. Pitcher, and R. J. Lefkowitz. “G protein-coupled receptor kinase 6A phosphorylates the Na(+)/H(+) exchanger regulatory factor via a PDZ domain-mediated interaction.” J Biol Chem 274, no. 34 (August 20, 1999): 24328–34. https://doi.org/10.1074/jbc.274.34.24328.Full Text Link to Item
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Goulet, J. L., R. C. Griffiths, P. Ruiz, R. F. Spurney, D. S. Pisetsky, B. H. Koller, and T. M. Coffman. “Deficiency of 5-lipoxygenase abolishes sex-related survival differences in MRL-lpr/lpr mice.” J Immunol 163, no. 1 (July 1, 1999): 359–66.Link to Item
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Spurney, R. F., M. Pi, P. Flannery, and L. D. Quarles. “Aluminum is a weak agonist for the calcium-sensing receptor.” Kidney Int 55, no. 5 (May 1999): 1750–58. https://doi.org/10.1046/j.1523-1755.1999.00432.x.Full Text Link to Item
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Spurney, R. F. “Role of C-terminal serines in desensitization and phosphorylation of the mouse thromboxane receptor.” J Biol Chem 273, no. 43 (October 23, 1998): 28496–503. https://doi.org/10.1074/jbc.273.43.28496.Full Text Link to Item
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Coffman, Thomas M., Robert F. Spurney, Roslyn B. Mannon, and Richard Levenson. “Thromboxane A2modulates the fibrinolytic system in glomerular mesangial cells.” Am J Physiol Renal Physiol 275, no. 2 (August 1, 1998): F262–69. https://doi.org/10.1152/ajprenal.1998.275.2.F262.Full Text Link to Item
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Weinman, E. J., D. Steplock, K. Tate, R. A. Hall, R. F. Spurney, and S. Shenolikar. “Structure-function of recombinant Na/H exchanger regulatory factor (NHE-RF).” J Clin Invest 101, no. 10 (May 15, 1998): 2199–2206. https://doi.org/10.1172/JCI204.Full Text Link to Item
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Spurney, R. F. “Effect of receptor number on desensitization of the mouse thromboxane receptor.” Biochem Pharmacol 55, no. 8 (April 15, 1998): 1271–81. https://doi.org/10.1016/s0006-2952(97)00633-3.Full Text Link to Item
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Spurney, R. F., and T. M. Coffman. “The C-terminus of the thromboxane receptor contributes to coupling and desensitization in a mouse mesangial cell line.” J Pharmacol Exp Ther 283, no. 1 (October 1997): 207–15.Link to Item
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Hartle, J. E., V. Prpic, S. R. Siddhanti, R. F. Spurney, and L. D. Quarles. “Differential regulation of receptor-stimulated cyclic adenosine monophosphate production by polyvalent cations in MC3T3-E1 osteoblasts.” J Bone Miner Res 11, no. 6 (June 1996): 789–99. https://doi.org/10.1002/jbmr.5650110610.Full Text Link to Item
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Best, V., P. Ruiz, and R. F. Spurney. “The Prostaglandin E(1) (PGE(1)) Analog Misoprostol Ameliorates Autoimmune Disease and Depletes T Lymphocytes in MRL-lpr/lpr Mice.” Am J Ther 2, no. 12 (December 1995): 943–48. https://doi.org/10.1097/00045391-199512000-00007.Full Text Link to Item
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Butterly, D. W., R. F. Spurney, P. Ruiz, E. Pirotzky, P. Braquet, and T. M. Coffman. “Role of platelet activating factor in kidney transplant rejection in the rat.” Kidney Int 48, no. 2 (August 1995): 337–43. https://doi.org/10.1038/ki.1995.301.Full Text Link to Item
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Garnovskaya, M. N., C. G. Nebigil, J. M. Arthur, R. F. Spurney, and J. R. Raymond. “5-Hydroxytryptamine2A receptors expressed in rat renal mesangial cells inhibit cyclic AMP accumulation.” Mol Pharmacol 48, no. 2 (August 1995): 230–37.Link to Item
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Fan, P. Y., P. Ruiz, D. S. Pisetsky, and R. F. Spurney. “The effects of short-term treatment with the prostaglandin E1 (PGE1) analog misoprostol on inflammatory mediator production in murine lupus nephritis.” Clin Immunol Immunopathol 75, no. 2 (May 1995): 125–30. https://doi.org/10.1006/clin.1995.1061.Full Text Link to Item
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Nebigil, C. G., M. N. Garnovskaya, R. F. Spurney, and J. R. Raymond. “Identification of a rat glomerular mesangial cell mitogenic 5-HT2A receptor.” American Journal of Physiology Renal Fluid and Electrolyte Physiology 268, no. 1 37-1 (January 1, 1995).
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Nebigil, C. G., M. N. Garnovskaya, R. F. Spurney, and J. R. Raymond. “Identification of a rat glomerular mesangial cell mitogenic 5-HT2A receptor.” Am J Physiol 268, no. 1 Pt 2 (January 1995): F122–27. https://doi.org/10.1152/ajprenal.1995.268.1.F122.Full Text Link to Item
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Spurney, R. F., P. Ruiz, C. R. Albrightson, D. S. Pisetsky, and T. M. Coffman. “Fish oil feeding modulates leukotriene production in murine lupus nephritis.” Prostaglandins 48, no. 5 (November 1994): 331–48. https://doi.org/10.1016/0090-6980(94)90032-9.Full Text Link to Item
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SPURNEY, R. F., J. P. MIDDLETON, J. R. RAYMOND, and T. M. COFFMAN. “MODULATION OF THROMBOXANE RECEPTOR ACTIVATION IN RAT GLOMERULAR MESANGIAL CELLS.” American Journal of Physiology 267, no. 3 (September 1, 1994): F467–78.Link to Item
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Spurney, R. F., J. P. Middleton, J. R. Raymond, and T. M. Coffman. “Modulation of thromboxane receptor activation in rat glomerular mesangial cells.” Am J Physiol 267, no. 3 Pt 2 (September 1994): F467–78. https://doi.org/10.1152/ajprenal.1994.267.3.F467.Full Text Link to Item
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GILKESON, G. S., D. S. PISETSKY, T. M. COFFMAN, R. F. SPURNEY, C. BEST, and J. B. WEINBERG. “CHRONIC BLOCKAGE OF NITRIC-OXIDE OVERPRODUCTION IN MRL-LPR MICE BY ORAL N(G) MONOMETHYL L-ARGININE (NMMA) PREVENTS INFLAMMATORY RENAL-DISEASE AND ENHANCES RENAL BLOOD-FLOW.” Clinical Research 42, no. 2 (April 1, 1994): A139–A139.Link to Item
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Spurney, R. F., S. Ibrahim, D. Butterly, P. E. Klotman, F. Sanfilippo, and T. M. Coffman. “Leukotrienes in renal transplant rejection in rats. Distinct roles for leukotriene B4 and peptidoleukotrienes in the pathogenesis of allograft injury.” J Immunol 152, no. 2 (January 15, 1994): 867–76.Link to Item
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Spurney, R. F., J. P. Middleton, J. R. Raymond, and T. M. Coffman. “Modulation of thromboxane receptor activation in rat glomerular mesangial cells.” Am.J.Physiol. 267, no. 3 part 2 (January 1, 1994).
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Coffman, T., S. Geier, S. Ibrahim, R. Griffiths, R. Spurney, O. Smithies, B. Koller, and F. Sanfilippo. “Improved renal function in mouse kidney allografts lacking MHC class I antigens.” J Immunol 151, no. 1 (July 1, 1993): 425–35.Link to Item
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Spurney, R. F., J. J. Onorato, P. Ruiz, D. S. Pisetsky, and T. M. Coffman. “Characterization of glomerular thromboxane receptors in murine lupus nephritis.” J Pharmacol Exp Ther 264, no. 2 (February 1993): 584–90.Link to Item
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Spurney, R. F., J. J. Onorato, F. J. Albers, and T. M. Coffman. “Thromboxane binding and signal transduction in rat glomerular mesangial cells.” Am J Physiol 264, no. 2 Pt 2 (February 1993): F292–99. https://doi.org/10.1152/ajprenal.1993.264.2.F292.Full Text Link to Item
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Ruiz, P., L. Rey, R. Spurney, T. Coffman, and A. Viciana. “Thromboxane augmentation of alloreactive T cell function.” Transplantation 54, no. 3 (September 1992): 498–505. https://doi.org/10.1097/00007890-199209000-00021.Full Text Link to Item
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Gilkeson, G. S., R. Spurney, T. M. Coffman, R. Kurlander, P. Ruiz, and D. S. Pisetsky. “Effect of anti-CD4 antibody treatment on inflammatory arthritis in MRL-lpr/lpr mice.” Clin Immunol Immunopathol 64, no. 2 (August 1992): 166–72. https://doi.org/10.1016/0090-1229(92)90195-t.Full Text Link to Item
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Spurney, R. F., P. Y. Fan, P. Ruiz, F. Sanfilippo, D. S. Pisetsky, and T. M. Coffman. “Thromboxane receptor blockade reduces renal injury in murine lupus nephritis.” Kidney Int 41, no. 4 (April 1992): 973–82. https://doi.org/10.1038/ki.1992.149.Full Text Link to Item
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Spurney, R. F., R. J. Bernstein, P. Ruiz, D. S. Pisetsky, and T. M. Coffman. “Physiologic role for enhanced renal thromboxane production in murine lupus nephritis.” Prostaglandins 42, no. 1 (July 1991): 15–28. https://doi.org/10.1016/0090-6980(91)90090-3.Full Text Link to Item
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Spurney, R. F., P. Ruiz, D. S. Pisetsky, and T. M. Coffman. “Enhanced renal leukotriene production in murine lupus: role of lipoxygenase metabolites.” Kidney Int 39, no. 1 (January 1991): 95–102. https://doi.org/10.1038/ki.1991.12.Full Text Link to Item
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Spurney, R. F., W. J. Fulkerson, and S. J. Schwab. “Acute renal failure in critically ill patients: prognosis for recovery of kidney function after prolonged dialysis support.” Crit Care Med 19, no. 1 (January 1991): 8–11. https://doi.org/10.1097/00003246-199101000-00007.Full Text Link to Item
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Spurney, R. F., S. D. Mayros, D. Collins, P. Ruiz, P. E. Klotman, and T. Coffman. “Thromboxane receptor blockade improves cyclosporine nephrotoxicity in rats.” Prostaglandins 39, no. 2 (February 1990): 135–46. https://doi.org/10.1016/0090-6980(90)90070-c.Full Text Link to Item
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Spurney, R. F., and K. M. McCormack. “Immature omental teratoma.” Arch Pathol Lab Med 111, no. 8 (August 1987): 762–64.Link to Item
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Conference Papers
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Hall, Gentzon, G Michelle Ducasa, Brandon M. Lane, Max Lagas, Maria E. Kovalik, Olivia G. Gregory, Guanghong Wu, et al. “THE LMX1 beta R246Q MUTATION INDUCES PODOCYTE INJURY THROUGH DYSREGULATION OF CHOLESTEROL TRANSPORT GENE EXPRESSION.” In Nephrology Dialysis Transplantation, Vol. 34. OXFORD UNIV PRESS, 2019.Link to Item
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Hall, Gentzon, Sidharth K. Sethi, Brandon M. Lane, Matthew G. Sampson, Olivia G. Gregory, Maria E. Kovalik, Megan Chryst-Stangl, et al. “A NOVEL HETEROZYGOUS MISSENSE MUTATION OF WILMS' TUMOR 1 MAY CAUSE FSGS THROUGH DYSREGULATED EXPRESSION OF ARHGAP24.” In Nephrology Dialysis Transplantation, Vol. 34. OXFORD UNIV PRESS, 2019.Link to Item
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Gesty-Palmer, D., R. F. Spurney, P. J. Flannery, and L. Yuan. “The PTH 1 receptor (PTH1R) Stimulates Bone Formation Through a Distinct beta-Arrestin Dependent Pathway Independent of G Protein Activation.” In Journal of Bone and Mineral Research, 23:S64–S64. AMER SOC BONE & MINERAL RES, 2008.Link to Item
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Wang, L., and R. F. Spurney. “G protein-coupled receptor (GPCR) kinase 2 (GRK2) inhibits canonical Wnt signaling.” In Journal of Bone and Mineral Research, 21:S99–S99. AMER SOC BONE & MINERAL RES, 2006.Link to Item
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Gesty-Palmer, D., E. Reiter, R. F. Spurney, L. M. Luttrell, and R. J. Lefkowitz. “Distinct conformations of the parathyroid hormone receptor mediate G protein and beta-arrestin dependent activation of ERK1/2.” In Journal of Bone and Mineral Research, 20:S182–S182. AMER SOC BONE & MINERAL RES, 2005.Link to Item
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Wang, L., and R. F. Spurney. “Enhanced bone mass in mice lacking G protein-coupled receptor kinases.” In Journal of Bone and Mineral Research, 20:S79–S79. AMER SOC BONE & MINERAL RES, 2005.Link to Item
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Wang, L., P. Flannery, and R. F. Spurney. “Overexpression of g protein-coupled receptor kinase 2 (GRK2) in osteoblasts decreases bone mass and reduced the anabolic effects of PTH(1-34).” In Journal of Bone and Mineral Research, 19:S337–S337. AMER SOC BONE & MINERAL RES, 2004.Link to Item
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Athirakul, K., A. J. Bradbury, J. Graves, L. Miller, J. X. Ma, L. Mao, H. Rockman, R. F. Spurney, T. M. Coffman, and D. C. Zeldin. “Hypertension in Cyp2j5 null mice is estrogen responsive.” In Journal of the American Society of Nephrology, 14:29A-29A. LIPPINCOTT WILLIAMS & WILKINS, 2003.Link to Item
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Burnham, C. E., R. F. Spurney, L. G. Simpson, A. J. Urdaneta, and D. Quarles. “Mice transgenic for FSGS-linked mutant actinin-4 (ACTN4) express elevated renal EGR-1 mRNA.” In Journal of the American Society of Nephrology, 14:334A-334A. LIPPINCOTT WILLIAMS & WILKINS, 2003.Link to Item
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Wang, L. M., H. David, and R. F. Spurney. “Activation of Gq-coupled signaling pathways in glomerular podocytes causes abnormalities in glomerular ultrastructure, albuminuria and reduces expression of nephrin mRNA.” In Journal of the American Society of Nephrology, 14:59A-59A. LIPPINCOTT WILLIAMS & WILKINS, 2003.Link to Item
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Coffman, T. M., R. F. Spurney, R. B. Mannon, and R. Levenson. “Thromboxane (TX) stimulates plasminogen activator inhibitor-1 (PAI-1) production by mesangial cells.” In Journal of the American Society of Nephrology, 7:A1985–A1985. AMER SOC NEPHROLOGY, 1996.Link to Item
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Spurney, R. F. “Role of C-terminal serines in agonist-induced desensitization of the mouse thromboxane A(2) (TxA(2)) receptor.” In Journal of the American Society of Nephrology, 7:A2200–A2200. AMER SOC NEPHROLOGY, 1996.Link to Item
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SPURNEY, R. F. “THROMBOXANE A(2) (TXA(2)) RECEPTOR NUMBER MODULATES DESENSITIZATION, BUT NOT DOWN-REGULATION, IN SV40-TRANSFORMED MOUSE MESANGIAL CELLS.” In Journal of the American Society of Nephrology, 6:812–812. WILLIAMS & WILKINS, 1995.Link to Item
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SPURNEY, R. F., and T. M. COFFMAN. “TRUNCATION OF THE CARBOXYL-TERMINUS OF THE THROMBOXANE A(2) (TXA(2)) RECEPTOR AFFECTS COUPLING AND DESENSITIZATION IN MOUSE MESANGIAL CELLS.” In Journal of the American Society of Nephrology, 6:761–761. WILLIAMS & WILKINS, 1995.Link to Item
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HARTLE, J. E., V. PRPIC, S. R. SIDDHANTI, R. F. SPURNEY, and L. D. QUARLES. “FUNCTIONAL-CHARACTERIZATION OF A CATION SENSING MECHANISM IN OSTEOBLASTS.” In Journal of Bone and Mineral Research, 10:S303–S303. BLACKWELL SCIENCE PUBL INC CAMBRIDGE, 1995.Link to Item
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COFFMAN, T. M., R. B. MANNON, V. BEST, and R. F. SPURNEY. “ISOLATION OF A GENOMIC CLONE THAT ENCODES A KIDNEY THROMBOXANE-A(2) (TXA(2)) RECEPTOR.” In Journal of the American Society of Nephrology, 5:678–678. WILLIAMS & WILKINS, 1994.Link to Item
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SPURNEY, R. F., T. M. COFFMAN, and J. P. MIDDLETON. “THROMBOXANE-A(2)[TXA(2)] ACTIVATES PROTEIN KINASE-C-ALPHA, AND KINASE-C-DELTA IN RAT GLOMERULAR MESANGIAL CELLS.” In Journal of the American Society of Nephrology, 5:731–731. WILLIAMS & WILKINS, 1994.Link to Item
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NEBIGIL, C., J. R. RAYMOND, R. F. SPURNEY, and M. GARNOVSKAYA. “MOLECULAR-CLONING AND MULTIPLE 2ND MESSENGER PATHWAYS OF A 5-HT(2)-RECEPTOR EXPRESSED IN RAT MESANGIAL CELLS.” In Faseb Journal, 8:A87–A87. FEDERATION AMER SOC EXP BIOL, 1994.Link to Item
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