Robert Frank Spurney | Scholars@Duke

Robert Frank Spurney
Professor of Medicine

Dr. Spurney’s research has focused on the role of G protein coupled receptors (GPCRs) in regulating cellular physiology both in normal and disease states as well as the regulatory mechanisms that modulate GPCR responsiveness at the molecular level. These studies have centered on two major themes. The first investigates the role of GPCR signaling pathways in regulating podocyte function using cultured podocytes and transgenic animals models. The second area of research involves the role of GPCR kinases (GRKs) and arrestin scaffolding proteins in modulating GPCR signaling in bone forming osteoblasts using cultured osteoblast cell lines as well as genetically modified mice including transgenic models and knockout animals. The long-term goal of these studies is to identify novel therapeutic targets that may useful for treating disease processes such as glomerulonephritis and osteoporosis.

Please see the Duke Nephrology Division website for more detailed information.

Current Appointments & Affiliations

Professor of Medicine, Medicine, Nephrology, Medicine 2012
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 1983

Contact Information

Box 103015, Duke University Medical Center, Durham, NC 27710
Duke Box 103015, Durham, NC 27710
spurn002@mc.duke.edu (919) 684-9729

Background
Education, Training, & Certifications
- Fellow in Nephrology, Medicine, Duke University 1987 - 1990
- Senior Assistant Resident, Medicine, Duke University 1986 - 1987
- Resident in Pathology, Pathology, Duke University 1985 - 1986
- Medical Resident, Medicine, Duke University 1983 - 1985
- M.D., Ohio State University 1983
Duke Appointment History
- Associate Professor of Medicine, Medicine, Nephrology, Medicine 2003 - 2011
- Associate Professor of Medicine, Medicine, Nephrology, Medicine 1997 - 2003
- Assistant Professor of Medicine, Medicine, Nephrology, Medicine 1993 - 1997
- Assistant Clinical Professor of Medicine, Medicine, Nephrology, Medicine 1992 - 1993
- Associate in the Department of Medicine, Medicine, Clinical Science Departments 1990 - 1992
Research
Selected Grants
- Duke Training Grant in Nephrology awarded by National Institutes of Health 1995 - 2022
- The Role of Interleukin-15 Receptor-alpha Variants in the Pathogenesis of FSGS awarded by National Institutes of Health 2017 - 2022
- The role of dendritic cell-mediated T cell activation in hypertension awarded by National Institutes of Health 2017 - 2019
- Functional and Phenotypic Characterization of a New FSGS Gene awarded by National Institutes of Health 2014 - 2019
- IPA extension - Liming Wang awarded by Durham Veterans Affairs Medical Center 2018 - 2019
- IPA - Cindy Chen awarded by Durham Veterans Affairs Medical Center 2018 - 2019
- Targeting TRPC6 to treat focal segmental glomerulosclerosis (FSGS) awarded by Amgen, Inc. 2016 - 2018
- Gene Discovery in Autosomal Dominant Focal Segmental Glomerulosclerosis awarded by National Institutes of Health 2012 - 2018
- Serial Block Face Scanning Electron Microscope awarded by National Institutes of Health 2016 - 2018
- IPA - Liming Wang awarded by Durham Veterans Affairs Medical Center 2016 - 2018
- Role of Gq Signaling in Promoting Podocyte Injury in Diabetes Mellitus awarded by National Institutes of Health 2011 - 2016
- IPA Extensioin - Wang awarded by Durham Veterans Affairs Medical Center 2013 - 2014
- IPA - Liming Wang awarded by Durham Veterans Affairs Medical Center 2011 - 2012
- A Novel Mouse Model of Podocyte Injury awarded by National Institutes of Health 2009 - 2012
- Molecular mechanisms of altered calcium sensing in human parathyroid disease awarded by National Institutes of Health 2010 - 2012
- Regulation of Podocyte Function by Angiotensin II awarded by National Institutes of Health 2004 - 2008
- Role of G-Protein coupled receptor kinases in Osteogenesis awarded by National Institutes of Health 2001 - 2006
- Pharmacologically Induced Neo-osteogenesis awarded by National Institutes of Health 1986 - 2004
- Thromboxane Receptor Regulation By Protein Kinases awarded by National Institutes of Health 1995 - 2000
Publications & Artistic Works
Selected Publications
- Journal Articles
  - Hall, G, and Spurney, RF. "Losing their footing: Rac1 signaling causes podocyte detachment and FSGS." Kidney international 92, no. 2 (August 2017): 283-285. Full Text
  - Wang, L, Sha, Y, Bai, J, Eisner, W, Sparks, MA, Buckley, AF, and Spurney, RF. "Podocyte-specific knockout of cyclooxygenase 2 exacerbates diabetic kidney disease." American journal of physiology. Renal physiology 313, no. 2 (August 2017): F430-F439. Full Text
  - Johnson, SA, and Spurney, RF. "Twenty years after ACEIs and ARBs: emerging treatment strategies for diabetic nephropathy." American journal of physiology. Renal physiology 309, no. 10 (November 2015): F807-F820. (Review) Full Text
  - Wang, L, Jirka, G, Rosenberg, PB, Buckley, AF, Gomez, JA, Fields, TA, Winn, MP, and Spurney, RF. "Gq signaling causes glomerular injury by activating TRPC6." The Journal of clinical investigation 125, no. 5 (May 2015): 1913-1926. Full Text
  - Hall, G, Gbadegesin, RA, Lavin, P, Wu, G, Liu, Y, Oh, EC, Wang, L, Spurney, RF, Eckel, J, Lindsey, T, Homstad, A, Malone, AF, Phelan, PJ, Shaw, A, Howell, DN, Conlon, PJ, Katsanis, N, and Winn, MP. "A novel missense mutation of Wilms' Tumor 1 causes autosomal dominant FSGS." Journal of the American Society of Nephrology : JASN 26, no. 4 (April 2015): 831-843. Full Text
  - Gbadegesin, RA, Hall, G, Adeyemo, A, Hanke, N, Tossidou, I, Burchette, J, Wu, G, Homstad, A, Sparks, MA, Gomez, J, Jiang, R, Alonso, A, Lavin, P, Conlon, P, Korstanje, R, Stander, MC, Shamsan, G, Barua, M, Spurney, R, Singhal, PC, Kopp, JB, Haller, H, Howell, D, Pollak, MR, Shaw, AS, Schiffer, M, and Winn, MP. "Mutations in the gene that encodes the F-actin binding protein anillin cause FSGS." Journal of the American Society of Nephrology : JASN 25, no. 9 (September 2014): 1991-2002. Full Text
  - Hall, G, Rowell, J, Farinelli, F, Gbadegesin, RA, Lavin, P, Wu, G, Homstad, A, Malone, A, Lindsey, T, Jiang, R, Spurney, R, Tomaselli, GF, Kass, DA, and Winn, MP. "Phosphodiesterase 5 inhibition ameliorates angiontensin II-induced podocyte dysmotility via the protein kinase G-mediated downregulation of TRPC6 activity." American journal of physiology. Renal physiology 306, no. 12 (June 2014): F1442-F1450. Full Text
  - Ortiz-Melo, DI, and Spurney, RF. "Special deLIVERy: podocyte injury promotes renal angiotensin II generation from liver-derived angiotensinogen." Kidney international 85, no. 5 (May 2014): 1009-1011. Full Text
  - Wang, L, Tang, Y, Eisner, W, Sparks, MA, Buckley, AF, and Spurney, RF. "Augmenting podocyte injury promotes advanced diabetic kidney disease in Akita mice." Biochemical and Biophysical Research Communications 444, no. 4 (February 21, 2014): 622-627. Full Text
  - Wang, L, Tang, Y, Eisner, W, Sparks, MA, Buckley, AF, and Spurney, RF. "Augmenting podocyte injury promotes advanced diabetic kidney disease in Akita mice." Biochemical and biophysical research communications 444, no. 4 (February 2014): 622-627. Full Text
  - Spurney, RF. "Non-immunologic actions of calcineurin inhibitors in proteinuric kidney diseases." Frontiers in endocrinology 5 (January 2014): 181-. (Review) Full Text
  - Wang, L, Fields, TA, Pazmino, K, Dai, Q, Burchette, JL, Howell, DN, Coffman, TM, and Spurney, RF. "Erratum: Activation of Gaq-coupled signaling pathways in glomerular podocytes promotes renal injury (Journal of the American Society of Nephrology (2005) 16 (3611-3622))." Journal of the American Society of Nephrology 24, no. 12 (December 9, 2013): 2126-. Full Text
  - Wang, X, Liao, S, Nelson, ER, Schmalzigaug, R, Spurney, RF, Guilak, F, Premont, RT, and Gesty-Palmer, D. "The cytoskeletal regulatory scaffold protein GIT2 modulates mesenchymal stem cell differentiation and osteoblastogenesis." Biochem Biophys Res Commun 425, no. 2 (August 24, 2012): 407-412. Full Text Link to Item
  - Zhang, J-D, Patel, MB, Song, Y-S, Griffiths, R, Burchette, J, Ruiz, P, Sparks, MA, Yan, M, Howell, DN, Gomez, JA, Spurney, RF, Coffman, TM, and Crowley, SD. "A novel role for type 1 angiotensin receptors on T lymphocytes to limit target organ damage in hypertension." Circ Res 110, no. 12 (June 8, 2012): 1604-1617. Full Text Link to Item
  - Wang, L, Ellis, MJ, Gomez, JA, Eisner, W, Fennell, W, Howell, DN, Ruiz, P, Fields, TA, and Spurney, RF. "Mechanisms of the proteinuria induced by Rho GTPases." Kidney Int 81, no. 11 (June 2012): 1075-1085. Full Text Link to Item
  - Chang, J-H, Paik, S-Y, Mao, L, Eisner, W, Flannery, PJ, Wang, L, Tang, Y, Mattocks, N, Hadjadj, S, Goujon, J-M, Ruiz, P, Gurley, SB, and Spurney, RF. "Diabetic kidney disease in FVB/NJ Akita mice: temporal pattern of kidney injury and urinary nephrin excretion." PLoS One 7, no. 4 (2012): e33942-. Full Text Link to Item
  - Wang, L, Tang, Y, Howell, DN, Ruiz, P, and Spurney, RF. "A novel mouse model of podocyte depletion." Nephron Exp Nephrol 121, no. 1-2 (2012): e10-e22. Full Text Link to Item
  - Wang, L, Chang, J-H, Paik, S-Y, Tang, Y, Eisner, W, and Spurney, RF. "Calcineurin (CN) activation promotes apoptosis of glomerular podocytes both in vitro and in vivo." Mol Endocrinol 25, no. 8 (August 2011): 1376-1386. Full Text Link to Item
  - Koh, J, Dar, M, Untch, BR, Dixit, D, Shi, Y, Yang, Z, Adam, MA, Dressman, H, Wang, X, Gesty-Palmer, D, Marks, JR, Spurney, R, Druey, KM, and Olson, JA. "Regulator of G protein signaling 5 is highly expressed in parathyroid tumors and inhibits signaling by the calcium-sensing receptor." Mol Endocrinol 25, no. 5 (May 2011): 867-876. Full Text Link to Item
  - Gesty-Palmer, D, Flannery, P, Yuan, L, Corsino, L, Spurney, R, Lefkowitz, RJ, and Luttrell, LM. "A beta-arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation." Sci Transl Med 1, no. 1 (October 7, 2009): 1ra1-. Full Text Link to Item
  - Wang, L, Gesty-Palmer, D, Fields, TA, and Spurney, RF. "Inhibition of WNT signaling by G protein-coupled receptor (GPCR) kinase 2 (GRK2)." Mol Endocrinol 23, no. 9 (September 2009): 1455-1465. Full Text Link to Item
  - Spurney, RF, and Coffman, TM. "Stressed-out podocytes in diabetes?." J Am Soc Nephrol 19, no. 11 (November 2008): 2035-2037. Full Text Link to Item
  - Wang, L, Flannery, PJ, Rosenberg, PB, Fields, TA, and Spurney, RF. "Gq-dependent signaling upregulates COX2 in glomerular podocytes." J Am Soc Nephrol 19, no. 11 (November 2008): 2108-2118. Full Text Link to Item
  - Wang, L, Ellis, MJ, Fields, TA, Howell, DN, and Spurney, RF. "Beneficial effects of the Rho kinase inhibitor Y27632 in murine puromycin aminonucleoside nephrosis." Kidney Blood Press Res 31, no. 2 (2008): 111-121. Full Text Link to Item
  - Wang, L, Flannery, PJ, Athirakul, K, Dunn, SR, Kourany, WM, and Spurney, RF. "Galphaq-dependent signaling cascades stimulate water-seeking behavior." Am J Physiol Renal Physiol 291, no. 4 (October 2006): F781-F789. Full Text Link to Item
  - Gesty-Palmer, D, Chen, M, Reiter, E, Ahn, S, Nelson, CD, Wang, S, Eckhardt, AE, Cowan, CL, Spurney, RF, Luttrell, LM, and Lefkowitz, RJ. "Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation." J Biol Chem 281, no. 16 (April 21, 2006): 10856-10864. Full Text Link to Item
  - Winn, MP, Daskalakis, N, Spurney, RF, and Middleton, JP. "Unexpected role of TRPC6 channel in familial nephrotic syndrome: does it have clinical implications?." J Am Soc Nephrol 17, no. 2 (February 2006): 378-387. (Review) Full Text Link to Item
  - Flannery, PJ, and Spurney, RF. "Transactivation of the epidermal growth factor receptor by angiotensin II in glomerular podocytes." Nephron Exp Nephrol 103, no. 3 (2006): e109-e118. Full Text Link to Item
  - Tanenbaum, ND, Howell, DN, Middleton, JP, and Spurney, RF. "Lambda light chain deposition disease in a renal allograft." Transplant Proc 37, no. 10 (December 2005): 4289-4292. Full Text Link to Item
  - Wang, L, Fields, TA, Pazmino, K, Dai, Q, Burchette, JL, Howell, DN, Coffman, TM, and Spurney, RF. "Activation of Galpha q-coupled signaling pathways in glomerular podocytes promotes renal injury." J Am Soc Nephrol 16, no. 12 (December 2005): 3611-3622. Full Text Link to Item
  - Rocha, PN, Plumb, TJ, Robinson, LA, Spurney, R, Pisetsky, D, Koller, BH, and Coffman, TM. "Role of thromboxane A2 in the induction of apoptosis of immature thymocytes by lipopolysaccharide." Clin Diagn Lab Immunol 12, no. 8 (August 2005): 896-903. Full Text Link to Item
  - Crowley, SD, Gurley, SB, Oliverio, MI, Pazmino, AK, Griffiths, R, Flannery, PJ, Spurney, RF, Kim, H-S, Smithies, O, Le, TH, and Coffman, TM. "Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system." J Clin Invest 115, no. 4 (April 2005): 1092-1099. Full Text Link to Item
  - Pi, M, Oakley, RH, Gesty-Palmer, D, Cruickshank, RD, Spurney, RF, Luttrell, LM, and Quarles, LD. "Beta-arrestin- and G protein receptor kinase-mediated calcium-sensing receptor desensitization." Mol Endocrinol 19, no. 4 (April 2005): 1078-1087. Full Text Link to Item
  - Wang, L, Liu, S, Quarles, LD, and Spurney, RF. "Targeted overexpression of G protein-coupled receptor kinase-2 in osteoblasts promotes bone loss." Am J Physiol Endocrinol Metab 288, no. 4 (April 2005): E826-E834. Full Text Link to Item
  - Wang, L, Quarles, LD, and Spurney, RF. "Unmasking the osteoinductive effects of a G-protein-coupled receptor (GPCR) kinase (GRK) inhibitor by treatment with PTH(1-34)." J Bone Miner Res 19, no. 10 (October 2004): 1661-1670. Full Text Link to Item
  - Thomas, DW, Rocha, PN, Nataraj, C, Robinson, LA, Spurney, RF, Koller, BH, and Coffman, TM. "Proinflammatory actions of thromboxane receptors to enhance cellular immune responses." J Immunol 171, no. 12 (December 15, 2003): 6389-6395. Link to Item
  - Wang, L, Flannery, PJ, and Spurney, RF. "Characterization of angiotensin II-receptor subtypes in podocytes." J Lab Clin Med 142, no. 5 (November 2003): 313-321. Full Text Link to Item
  - Le, TH, Kim, H-S, Allen, AM, Spurney, RF, Smithies, O, and Coffman, TM. "Physiological impact of increased expression of the AT1 angiotensin receptor." Hypertension 42, no. 4 (October 2003): 507-514. Full Text Link to Item
  - Spurney, RF. "Regulated expression of G protein-coupled receptor kinases (GRK's) and beta-arrestins in osteoblasts." Calcif Tissue Int 73, no. 2 (August 2003): 153-160. Full Text Link to Item
  - Tharaux, P-L, Bukoski, RC, Rocha, PN, Crowley, SD, Ruiz, P, Nataraj, C, Howell, DN, Kaibuchi, K, Spurney, RF, and Coffman, TM. "Rho kinase promotes alloimmune responses by regulating the proliferation and structure of T cells." J Immunol 171, no. 1 (July 1, 2003): 96-105. Link to Item
  - Pi, M, Spurney, RF, Tu, Q, Hinson, T, and Quarles, LD. "Calcium-sensing receptor activation of rho involves filamin and rho-guanine nucleotide exchange factor." Endocrinology 143, no. 10 (October 2002): 3830-3838. Full Text Link to Item
  - Flannery, PJ, and Spurney, RF. "Desensitization of the mouse thromboxane A2 receptor (TP) by G protein-coupled receptor kinases (Grks)." Prostaglandins Other Lipid Mediat 70, no. 1-2 (September 2002): 79-90. Link to Item
  - Spurney, RF, Flannery, PJ, Garner, SC, Athirakul, K, Liu, S, Guilak, F, and Quarles, LD. "Anabolic effects of a G protein-coupled receptor kinase inhibitor expressed in osteoblasts." J Clin Invest 109, no. 10 (May 2002): 1361-1371. Full Text Link to Item
  - Flannery, PJ, and Spurney, RF. "Domains of the parathyroid hormone (PTH) receptor required for regulation by G protein-coupled receptor kinases (GRKs)." Biochem Pharmacol 62, no. 8 (October 15, 2001): 1047-1058. Link to Item
  - Guo, R, Liu, S, Spurney, RF, and Quarles, LD. "Analysis of recombinant Phex: an endopeptidase in search of a substrate." Am J Physiol Endocrinol Metab 281, no. 4 (October 2001): E837-E847. Full Text Link to Item
  - Spurney, RF. "Regulation of thromboxane receptor (TP) phosphorylation by protein phosphatase 1 (PP1) and PP2A." J Pharmacol Exp Ther 296, no. 2 (February 2001): 592-599. Link to Item
  - Guo, R, Liu, S, Spurney, RF, and Quarles, LD. "Analysis of recombinant Phex: An endopeptidase in search of a substrate." American Journal of Physiology - Endocrinology and Metabolism 281, no. 4 44-4 (2001): E837-E847.
  - Butterly, DW, Spurney, RF, Ruiz, P, Griffiths, R, Albrightson, C, and Coffman, TM. "A role for leukotrienes in cyclosporine nephrotoxicity." Kidney Int 57, no. 6 (June 2000): 2586-2593. Full Text Link to Item
  - Pi, M, Garner, SC, Flannery, P, Spurney, RF, and Quarles, LD. "Sensing of extracellular cations in CasR-deficient osteoblasts. Evidence for a novel cation-sensing mechanism." J Biol Chem 275, no. 5 (February 4, 2000): 3256-3263. Link to Item
  - Hall, RA, Spurney, RF, Premont, RT, Rahman, N, Blitzer, JT, Pitcher, JA, and Lefkowitz, RJ. "G protein-coupled receptor kinase 6A phosphorylates the Na(+)/H(+) exchanger regulatory factor via a PDZ domain-mediated interaction." J Biol Chem 274, no. 34 (August 20, 1999): 24328-24334. Link to Item
  - Goulet, JL, Griffiths, RC, Ruiz, P, Spurney, RF, Pisetsky, DS, Koller, BH, and Coffman, TM. "Deficiency of 5-lipoxygenase abolishes sex-related survival differences in MRL-lpr/lpr mice." J Immunol 163, no. 1 (July 1, 1999): 359-366. Link to Item
  - Spurney, RF, Pi, M, Flannery, P, and Quarles, LD. "Aluminum is a weak agonist for the calcium-sensing receptor." Kidney Int 55, no. 5 (May 1999): 1750-1758. Full Text Link to Item
  - Spurney, RF. "Role of C-terminal serines in desensitization and phosphorylation of the mouse thromboxane receptor." J Biol Chem 273, no. 43 (October 23, 1998): 28496-28503. Link to Item
  - Coffman, TM, Spurney, RF, Mannon, RB, and Levenson, R. "Thromboxane A2 modulates the fibrinolytic system in glomerular mesangial cells." Am J Physiol 275, no. 2 Pt 2 (August 1998): F262-F269. Link to Item
  - Weinman, EJ, Steplock, D, Tate, K, Hall, RA, Spurney, RF, and Shenolikar, S. "Structure-function of recombinant Na/H exchanger regulatory factor (NHE-RF)." J Clin Invest 101, no. 10 (May 15, 1998): 2199-2206. Full Text Link to Item
  - Spurney, RF. "Effect of receptor number on desensitization of the mouse thromboxane receptor." Biochem Pharmacol 55, no. 8 (April 15, 1998): 1271-1281. Link to Item
  - Coffman, TM, Spurney, RF, Mannon, RB, and Levenson, R. "Thromboxane A₂ modulates the fibrinolytic system in glomerular mesangial cells." American Journal of Physiology - Renal Physiology 275, no. 2 44-2 (1998): F262-F269.
  - Spurney, RF, and Coffman, TM. "The C-terminus of the thromboxane receptor contributes to coupling and desensitization in a mouse mesangial cell line." J Pharmacol Exp Ther 283, no. 1 (October 1997): 207-215. Link to Item
  - Hartle, JE, Prpic, V, Siddhanti, SR, Spurney, RF, and Quarles, LD. "Differential regulation of receptor-stimulated cyclic adenosine monophosphate production by polyvalent cations in MC3T3-E1 osteoblasts." J Bone Miner Res 11, no. 6 (June 1996): 789-799. Full Text Link to Item
  - Best, V, Ruiz, P, and Spurney, RF. "The Prostaglandin E(1) (PGE(1)) Analog Misoprostol Ameliorates Autoimmune Disease and Depletes T Lymphocytes in MRL-lpr/lpr Mice." Am J Ther 2, no. 12 (December 1995): 943-948. Link to Item
  - Butterly, DW, Spurney, RF, Ruiz, P, Pirotzky, E, Braquet, P, and Coffman, TM. "Role of platelet activating factor in kidney transplant rejection in the rat." Kidney Int 48, no. 2 (August 1995): 337-343. Link to Item
  - Garnovskaya, MN, Nebigil, CG, Arthur, JM, Spurney, RF, and Raymond, JR. "5-Hydroxytryptamine2A receptors expressed in rat renal mesangial cells inhibit cyclic AMP accumulation." Mol Pharmacol 48, no. 2 (August 1995): 230-237. Link to Item
  - Fan, PY, Ruiz, P, Pisetsky, DS, and Spurney, RF. "The effects of short-term treatment with the prostaglandin E1 (PGE1) analog misoprostol on inflammatory mediator production in murine lupus nephritis." Clin Immunol Immunopathol 75, no. 2 (May 1995): 125-130. Link to Item
  - Nebigil, CG, Garnovskaya, MN, Spurney, RF, and Raymond, JR. "Identification of a rat glomerular mesangial cell mitogenic 5-HT2A receptor." Am J Physiol 268, no. 1 Pt 2 (January 1995): F122-F127. Full Text Link to Item
  - Nebigil, CG, Garnovskaya, MN, Spurney, RF, and Raymond, JR. "Identification of a rat glomerular mesangial cell mitogenic 5-HT_2A receptor." American Journal of Physiology - Renal Fluid and Electrolyte Physiology 268, no. 1 37-1 (1995): F122-F127.
  - Spurney, RF, Ruiz, P, Albrightson, CR, Pisetsky, DS, and Coffman, TM. "Fish oil feeding modulates leukotriene production in murine lupus nephritis." Prostaglandins 48, no. 5 (November 1994): 331-348. Link to Item
  - Spurney, RF, Middleton, JP, Raymond, JR, and Coffman, TM. "Modulation of thromboxane receptor activation in rat glomerular mesangial cells." Am J Physiol 267, no. 3 Pt 2 (September 1994): F467-F478. Full Text Link to Item
  - Spurney, RF, Ibrahim, S, Butterly, D, Klotman, PE, Sanfilippo, F, and Coffman, TM. "Leukotrienes in renal transplant rejection in rats. Distinct roles for leukotriene B4 and peptidoleukotrienes in the pathogenesis of allograft injury." J Immunol 152, no. 2 (January 15, 1994): 867-876. Link to Item
  - Nebigil, CG, Garnovskaya, MN, Spurney, RF, and Raymond, JR. "Identification of a rat glomerular mesangial cell mitogenic 5-HT_2A receptor." American Journal of Physiology - Renal Physiology 268, no. 1 (1994): F122-F127.
  - Spurney, RF, Middleton, JP, Raymond, JR, and Coffman, TM. "Modulation of thromboxane receptor activation in rat glomerular mesangial cells." AM.J.PHYSIOL. 267, no. 3 part 2 (1994): F467-F478.
  - Spurney, RF, Middleton, JP, Raymond, JR, and Coffman, TM. "Modulation of thromboxane receptor activation in rat glomerular mesangial cells." American Journal of Physiology - Renal Fluid and Electrolyte Physiology 267, no. 3 36-3 (1994): F467-F478.
  - Spurney, RF, Onorato, JJ, Albers, FJ, and Coffman, TM. "Thromboxane binding and signal transduction in rat glomerular mesangial cells." Am J Physiol 264, no. 2 Pt 2 (February 1993): F292-F299. Full Text Link to Item
  - Spurney, RF, Onorato, JJ, Ruiz, P, Pisetsky, DS, and Coffman, TM. "Characterization of glomerular thromboxane receptors in murine lupus nephritis." J Pharmacol Exp Ther 264, no. 2 (February 1993): 584-590. Link to Item
  - Coffman, T, Geier, S, Ibrahim, S, Griffiths, R, Spurney, R, Smithies, O, Koller, B, and Sanfilippo, F. "Improved renal function in mouse kidney allografts lacking MHC class I antigens." Journal of Immunology 151, no. 1 (1993): 425-435.
  - Spurney, RF, Onorato, JJ, Albers, FJ, and Coffman, TM. "Thromboxane binding and signal transduction in rat glomerular mesangial cells." American Journal of Physiology - Renal Fluid and Electrolyte Physiology 264, no. 2 33-2 (1993): F292-F299.
  - Gilkeson, GS, Spurney, R, Coffman, TM, Kurlander, R, Ruiz, P, and Pisetsky, DS. "Effect of anti-CD4 antibody treatment on inflammatory arthritis in MRL-lpr/lpr mice." Clin Immunol Immunopathol 64, no. 2 (August 1992): 166-172. Link to Item
  - Spurney, RF, Fan, PY, Ruiz, P, Sanfilippo, F, Pisetsky, DS, and Coffman, TM. "Thromboxane receptor blockade reduces renal injury in murine lupus nephritis." Kidney Int 41, no. 4 (April 1992): 973-982. Link to Item
  - Ruiz, P, Rey, L, Spurney, R, Coffman, T, and Viciana, A. "Thromboxane augmentation of alloreactive T cell function." Transplantation 54, no. 3 (1992): 498-505.
  - Spurney, RF, Bernstein, RJ, Ruiz, P, Pisetsky, DS, and Coffman, TM. "Physiologic role for enhanced renal thromboxane production in murine lupus nephritis." Prostaglandins 42, no. 1 (July 1991): 15-28. Link to Item
  - Spurney, RF, Fulkerson, WJ, and Schwab, SJ. "Acute renal failure in critically ill patients: prognosis for recovery of kidney function after prolonged dialysis support." Crit Care Med 19, no. 1 (January 1991): 8-11. Link to Item
  - Spurney, RF, Ruiz, P, Pisetsky, DS, and Coffman, TM. "Enhanced renal leukotriene production in murine lupus: role of lipoxygenase metabolites." Kidney Int 39, no. 1 (January 1991): 95-102. Link to Item
  - Spurney, RF, Mayros, SD, Collins, D, Ruiz, P, Klotman, PE, and Coffman, T. "Thromboxane receptor blockade improves cyclosporine nephrotoxicity in rats." Prostaglandins 39, no. 2 (February 1990): 135-146. Link to Item
  - Spurney, RF, and McCormack, KM. "Immature omental teratoma." Arch Pathol Lab Med 111, no. 8 (August 1987): 762-764. Link to Item

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Education, Training, & Certifications

Duke Appointment History

Selected Grants

Selected Publications

Journal Articles