Stefano Di Talia
Assistant Professor of Cell Biology
Current Appointments & Affiliations
- Assistant Professor of Cell Biology, Cell Biology, Basic Science Departments 2014
- Assistant Professor in Orthopaedic Surgery, Orthopaedics, Orthopaedics 2019
- Affiliate of the Regeneration Next Initiative, Regeneration Next Initiative, Institutes and Centers 2016
Contact Information
- Background
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Education, Training, & Certifications
- Ph.D., Rockefeller University 2009
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Duke Appointment History
- Instructor, Temporary in the Department of Cell Biology, Cell Biology, Basic Science Departments 2013 - 2014
- Recognition
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In the News
- Research
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Selected Grants
- Time-keeping mechanisms of embryonic cell cycles awarded by National Institutes of Health 2017 - 2022
- Training Program in Developmental and Stem Cell Biology awarded by National Institutes of Health 2001 - 2022
- Control of Tissue Geometry Through Signaling Waves During Regeneration 2019 - 2021
- An integrative cellular blueprint of vertebrate tissue development 2018 - 2020
- Bioinformatics and Computational Biology Training Program awarded by National Institutes of Health 2005 - 2020
- Genetics Training Grant awarded by National Institutes of Health 1979 - 2020
- Genetics Training Grant awarded by National Institutes of Health 1979 - 2020
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- Regulation of the Epicardial Injury Response During Heart Regeneration in Zebrafish awarded by National Institutes of Health 2016 - 2019
- An integrative cellular blueprint of vertebrate tissue development 2018 - 2019
- Regulation of Appendage Regeneration in Zebrafish awarded by National Institutes of Health 2006 - 2018
- Time-Keeping Mechanisms in Drosophila Embryonic Development awarded by National Institutes of Health 2014 - 2017
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Deneke, Victoria E., Alberto Puliafito, Daniel Krueger, Avaneesh V. Narla, Alessandro De Simone, Luca Primo, Massimo Vergassola, Stefano De Renzis, and Stefano Di Talia. “Self-Organized Nuclear Positioning Synchronizes the Cell Cycle in Drosophila Embryos..” Cell 177, no. 4 (May 2, 2019): 925-941.e17. https://doi.org/10.1016/j.cell.2019.03.007.Full Text Link to Item
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Ferree, Patrick, and Stefano Di Talia. “Developmental Biology: Embryos Need to Control Their Nucleotides Just Right..” Curr Biol 29, no. 7 (April 1, 2019): R252–54. https://doi.org/10.1016/j.cub.2019.02.051.Full Text Link to Item
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Cox, Ben D., Alessandro De Simone, Valerie A. Tornini, Sumeet P. Singh, Stefano Di Talia, and Kenneth D. Poss. “In Toto Imaging of Dynamic Osteoblast Behaviors in Regenerating Skeletal Bone..” Curr Biol 28, no. 24 (December 17, 2018): 3937-3947.e4. https://doi.org/10.1016/j.cub.2018.10.052.Full Text Link to Item
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Ferree, P. L., and S. Di Talia. “Chemical Waves in Embryonic Cell Cycles.” Israel Journal of Chemistry 58, no. 6 (June 1, 2018): 714–21. https://doi.org/10.1002/ijch.201700144.Full Text
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Deneke, Victoria E., and Stefano Di Talia. “Chemical waves in cell and developmental biology..” J Cell Biol 217, no. 4 (April 2, 2018): 1193–1204. https://doi.org/10.1083/jcb.201701158.Full Text Link to Item
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Vergassola, Massimo, Victoria E. Deneke, and Stefano Di Talia. “Mitotic waves in the early embryogenesis of Drosophila: Bistability traded for speed..” Proc Natl Acad Sci U S A 115, no. 10 (March 6, 2018): E2165–74. https://doi.org/10.1073/pnas.1714873115.Full Text Link to Item
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Cao, Jingli, Jinhu Wang, Christopher P. Jackman, Amanda H. Cox, Michael A. Trembley, Joseph J. Balowski, Ben D. Cox, et al. “Tension Creates an Endoreplication Wavefront that Leads Regeneration of Epicardial Tissue..” Dev Cell 42, no. 6 (September 25, 2017): 600-615.e4. https://doi.org/10.1016/j.devcel.2017.08.024.Full Text Link to Item
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Ferree, Patrick L., and Stefano Di Talia. “For Embryos, Mother Can Only Take You So Far..” Dev Cell 42, no. 3 (August 7, 2017): 203–5. https://doi.org/10.1016/j.devcel.2017.07.016.Full Text Link to Item
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Tornini, Valerie A., Alberto Puliafito, Leslie A. Slota, John D. Thompson, Gregory Nachtrab, Anna-Lila Kaushik, Marika Kapsimali, Luca Primo, Stefano Di Talia, and Kenneth D. Poss. “Live Monitoring of Blastemal Cell Contributions during Appendage Regeneration..” Curr Biol 26, no. 22 (November 21, 2016): 2981–91. https://doi.org/10.1016/j.cub.2016.08.072.Full Text Link to Item
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Di Talia, Stefano, and Kenneth D. Poss. “Monitoring Tissue Regeneration at Single-Cell Resolution..” Cell Stem Cell 19, no. 4 (October 6, 2016): 428–31. https://doi.org/10.1016/j.stem.2016.09.007.Full Text Link to Item
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Momen-Roknabadi, Amir, Stefano Di Talia, and Eric Wieschaus. “Transcriptional Timers Regulating Mitosis in Early Drosophila Embryos..” Cell Rep 16, no. 11 (September 13, 2016): 2793–2801. https://doi.org/10.1016/j.celrep.2016.08.034.Full Text Link to Item
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Deneke, Victoria E., Anna Melbinger, Massimo Vergassola, and Stefano Di Talia. “Waves of Cdk1 Activity in S Phase Synchronize the Cell Cycle in Drosophila Embryos..” Dev Cell 38, no. 4 (August 22, 2016): 399–412. https://doi.org/10.1016/j.devcel.2016.07.023.Full Text Link to Item
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Ferree, Patrick L., Victoria E. Deneke, and Stefano Di Talia. “Measuring time during early embryonic development..” Semin Cell Dev Biol 55 (July 2016): 80–88. https://doi.org/10.1016/j.semcdb.2016.03.013.Full Text Link to Item
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Chen, Chen-Hui, Alberto Puliafito, Ben D. Cox, Luca Primo, Yi Fang, Stefano Di Talia, and Kenneth D. Poss. “Multicolor Cell Barcoding Technology for Long-Term Surveillance of Epithelial Regeneration in Zebrafish..” Dev Cell 36, no. 6 (March 21, 2016): 668–80. https://doi.org/10.1016/j.devcel.2016.02.017.Full Text Link to Item
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Xenopoulos, Panagiotis, Minjung Kang, Alberto Puliafito, Stefano Di Talia, and Anna-Katerina Hadjantonakis. “Heterogeneities in Nanog Expression Drive Stable Commitment to Pluripotency in the Mouse Blastocyst..” Cell Rep 10, no. 9 (March 10, 2015): 1508–20. https://doi.org/10.1016/j.celrep.2015.02.010.Full Text Link to Item
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Di Talia, Stefano, and Eric F. Wieschaus. “Simple biochemical pathways far from steady state can provide switchlike and integrated responses..” Biophys J 107, no. 3 (August 5, 2014): L1–4. https://doi.org/10.1016/j.bpj.2014.06.018.Full Text Link to Item
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Schrode, Nadine, Néstor Saiz, Stefano Di Talia, and Anna-Katerina Hadjantonakis. “GATA6 levels modulate primitive endoderm cell fate choice and timing in the mouse blastocyst..” Dev Cell 29, no. 4 (May 27, 2014): 454–67. https://doi.org/10.1016/j.devcel.2014.04.011.Full Text Link to Item
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Di Talia, Stefano, Richard She, Shelby A. Blythe, Xuemin Lu, Qi Fan Zhang, and Eric F. Wieschaus. “Posttranslational control of Cdc25 degradation terminates Drosophila's early cell-cycle program..” Curr Biol 23, no. 2 (January 21, 2013): 127–32. https://doi.org/10.1016/j.cub.2012.11.029.Full Text Link to Item
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Di Talia, Stefano, and Eric F. Wieschaus. “Short-term integration of Cdc25 dynamics controls mitotic entry during Drosophila gastrulation..” Dev Cell 22, no. 4 (April 17, 2012): 763–74. https://doi.org/10.1016/j.devcel.2012.01.019.Full Text Link to Item
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Zilman, Anton, Stefano Di Talia, Tijana Jovanovic-Talisman, Brian T. Chait, Michael P. Rout, and Marcelo O. Magnasco. “Enhancement of transport selectivity through nano-channels by non-specific competition..” Plos Comput Biol 6, no. 6 (June 10, 2010). https://doi.org/10.1371/journal.pcbi.1000804.Full Text Link to Item
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Zilman, A., S. D. Talia, T. Jovanovic-Talisman, B. T. Chait, M. P. Rout, and M. O. Magnasco. “Enhancement of transport selectivity through nano-channels by non-specific competition..” Plos Computational Biology 6, no. 6 (2010). https://doi.org/10.1371/journal.pcbi.1000804.Full Text
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Di Talia, Stefano, Hongyin Wang, Jan M. Skotheim, Adam P. Rosebrock, Bruce Futcher, and Frederick R. Cross. “Daughter-specific transcription factors regulate cell size control in budding yeast..” Plos Biol 7, no. 10 (October 2009). https://doi.org/10.1371/journal.pbio.1000221.Full Text Link to Item
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Skotheim, Jan M., Stefano Di Talia, Eric D. Siggia, and Frederick R. Cross. “Positive feedback of G1 cyclins ensures coherent cell cycle entry..” Nature 454, no. 7202 (July 17, 2008): 291–96. https://doi.org/10.1038/nature07118.Full Text Link to Item
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Di Talia, S., J. M. Skotheim, J. M. Bean, E. D. Siggia, and F. R. Cross. “The effects of molecular noise and size control on variability in the budding yeast cell cycle (Nature (2007) 448, (947-951)).” Nature 450, no. 7173 (December 20, 2007). https://doi.org/10.1038/nature06511.Full Text
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Di Talia, Stefano, Jan M. Skotheim, James M. Bean, Eric D. Siggia, and Frederick R. Cross. “The effects of molecular noise and size control on variability in the budding yeast cell cycle..” Nature 448, no. 7156 (August 23, 2007): 947–51. https://doi.org/10.1038/nature06072.Full Text Link to Item
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Zilman, Anton, Stefano Di Talia, Brian T. Chait, Michael P. Rout, and Marcelo O. Magnasco. “Efficiency, selectivity, and robustness of nucleocytoplasmic transport..” Plos Comput Biol 3, no. 7 (July 2007). https://doi.org/10.1371/journal.pcbi.0030125.Full Text Link to Item
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Candia, Antonio de, Andrea Gamba, Fausto Cavalli, Antonio Coniglio, Stefano Di Talia, Federico Bussolino, and Guido Serini. “A simulation environment for directional sensing as a phase separation process..” Science’S Stke : Signal Transduction Knowledge Environment 2007, no. 378 (March 20, 2007). https://doi.org/10.1126/stke.3782007pl1.Full Text
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Zilman, A., S. D. Talia, B. T. Chait, M. P. Rout, and M. O. Magnasco. “Efficiency, selectivity, and robustness of nucleocytoplasmic transport..” Plos Computational Biology 3, no. 7 (2007). https://doi.org/10.1371/journal.pcbi.0030125.Full Text
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Di Talia, S., A. Gamba, F. Lamberti, and G. Serini. “Role of repulsive factors in vascularization dynamics..” Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics 73, no. 4 Pt 1 (April 14, 2006). https://doi.org/10.1103/physreve.73.041917.Full Text
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Gamba, Andrea, Antonio de Candia, Stefano Di Talia, Antonio Coniglio, Federico Bussolino, and Guido Serini. “Diffusion-limited phase separation in eukaryotic chemotaxis..” Proc Natl Acad Sci U S A 102, no. 47 (November 22, 2005): 16927–32. https://doi.org/10.1073/pnas.0503974102.Full Text Link to Item
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Coniglio, A., A. De Candia, S. Di Talia, and A. Gamba. “Erratum: Percolation and Burgers' dynamics in a model of capillary formation (Physical Review E (2004) 69 (051910)).” Physical Review E Statistical, Nonlinear, and Soft Matter Physics 70, no. 3 2 (September 1, 2004): 039902–039901. https://doi.org/10.1103/PhysRevE.70.039902.Full Text
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Coniglio, A., A. de Candia, S. Di Talia, and A. Gamba. “Percolation and Burgers' dynamics in a model of capillary formation..” Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics 69, no. 5 Pt 1 (May 24, 2004). https://doi.org/10.1103/physreve.69.051910.Full Text
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Coniglio, A., A. De Candia, S. Di Talia, and A. Gamba. “Percolation and Burgers' dynamics in a model of capillary formation.” Physical Review E Statistical, Nonlinear, and Soft Matter Physics 69, no. 5 2 (January 1, 2004).
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Gamba, A., D. Ambrosi, A. Coniglio, A. de Candia, S. Di Talia, E. Giraudo, G. Serini, L. Preziosi, and F. Bussolino. “Percolation, morphogenesis, and burgers dynamics in blood vessels formation..” Phys Rev Lett 90, no. 11 (March 21, 2003). https://doi.org/10.1103/PhysRevLett.90.118101.Full Text Link to Item
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Conference Papers
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Deneke, V., M. Vergassola, A. Puliafito, and S. Di Talia. “Physical and molecular mechanisms of cell cycle synchronization in early Drosophila embryos..” In Molecular Biology of the Cell, Vol. 28. AMER SOC CELL BIOLOGY, 2017.Link to Item
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Falahati, H., S. Di Talia, and E. Wieschaus. “Temperature-induced uncoupling of cell cycle regulatory mechanisms..” In Molecular Biology of the Cell, Vol. 28. AMER SOC CELL BIOLOGY, 2017.Link to Item
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Saiz, N., M. Kang, A. Puliafito, N. Schrode, P. Xenopoulos, X. Lou, S. Di Talia, and A. K. Hadjantonakis. “Quantitative analyses for elucidating mechanisms of cell fate commitment in the mouse blastocyst.” In Progress in Biomedical Optics and Imaging Proceedings of Spie, Vol. 9334, 2015. https://doi.org/10.1117/12.2081232.Full Text
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Roknabadi, A Momen, S. Di Talia, and E. Wieschaus. “Studying The Regulation of Temporal Patterning of String Transcription in Early Drosophila Cell Cycles..” In Molecular Biology of the Cell, Vol. 25. AMER SOC CELL BIOLOGY, 2014.Link to Item
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Gamba, A., A. De Candia, S. Di Talia, A. Coniglio, F. Bussolino, and G. Serini. “Phase separation in eukaryotic directional sensing,” 38:23–32, 2007. https://doi.org/10.1007/978-0-8176-4558-8_3.Full Text
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Gamba, A., A. De Candia, F. Cavalli, S. Di Talia, A. Coniglio, F. Bussolino, and G. Serini. “A computational model for eukaryotic directional sensing.” In Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), 4210 LNBI:184–95, 2006.
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- Teaching & Mentoring
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Recent Courses
- CELLBIO 493: Research Independent Study 2019
- CMB 640: Quantitative Approaches to Biological Problems: From Cartoon Models to System Behavior 2019
- CMB 710E: Cell & Molecular Biology Module V 2019
- UPGEN 640: Quantitative Approaches to Biological Problems: From Cartoon Models to System Behavior 2019
- CMB 710B: Cell & Molecular Biology Module II 2018
- UPGEN 716S: Genetics Student Research 2017
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