Scholars@Duke

• Background
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  Education, Training, & Certifications

  • Ph.D., Rockefeller University 2009
• 

  Duke Appointment History

  • Instructor, Temporary in the Department of Cell Biology, Cell Biology, Basic Science Departments 2013 - 2014
• Recognition
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  In the News

  • MAY 2, 2019

    Developing Cells Do Synchronized Swimming Inside the Embryo
• Research
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  Selected Grants

  • Time-keeping mechanisms of embryonic cell cycles awarded by National Institutes of Health 2017 - 2022
  • Training Program in Developmental and Stem Cell Biology awarded by National Institutes of Health 2001 - 2022
  • Genetics Training Grant awarded by National Institutes of Health 1979 - 2020
  • Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
  • Regulation of the Epicardial Injury Response During Heart Regeneration in Zebrafish awarded by National Institutes of Health 2016 - 2019
  • An integrative cellular blueprint of vertebrate tissue development awarded by University of California - San Diego 2018 - 2019
  • Regulation of Appendage Regeneration in Zebrafish awarded by National Institutes of Health 2006 - 2018
  • Time-Keeping Mechanisms in Drosophila Embryonic Development awarded by National Institutes of Health 2014 - 2017
• Publications & Artistic Works
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  Selected Publications

  • Academic Articles

    • Deneke, Victoria E., Alberto Puliafito, Daniel Krueger, Avaneesh V. Narla, Alessandro De Simone, Luca Primo, Massimo Vergassola, Stefano De Renzis, and Stefano Di Talia. “Self-Organized Nuclear Positioning Synchronizes the Cell Cycle in Drosophila Embryos..” Cell 177, no. 4 (May 2, 2019): 925-941.e17. https://doi.org/10.1016/j.cell.2019.03.007.
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    • Ferree, Patrick, and Stefano Di Talia. “Developmental Biology: Embryos Need to Control Their Nucleotides Just Right..” Current Biology : Cb 29, no. 7 (April 2019): R252–54. https://doi.org/10.1016/j.cub.2019.02.051.
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    • Cox, Ben D., Alessandro De Simone, Valerie A. Tornini, Sumeet P. Singh, Stefano Di Talia, and Kenneth D. Poss. “In Toto Imaging of Dynamic Osteoblast Behaviors in Regenerating Skeletal Bone..” Current Biology : Cb 28, no. 24 (December 2018): 3937-3947.e4. https://doi.org/10.1016/j.cub.2018.10.052.
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    • Ferree, P. L., and S. Di Talia. “Chemical Waves in Embryonic Cell Cycles.” Israel Journal of Chemistry 58, no. 6 (June 1, 2018): 714–21. https://doi.org/10.1002/ijch.201700144.
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    • Deneke, Victoria E., and Stefano Di Talia. “Chemical waves in cell and developmental biology..” The Journal of Cell Biology 217, no. 4 (April 2018): 1193–1204. https://doi.org/10.1083/jcb.201701158.
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    • Vergassola, Massimo, Victoria E. Deneke, and Stefano Di Talia. “Mitotic waves in the early embryogenesis of Drosophila: Bistability traded for speed..” Proceedings of the National Academy of Sciences of the United States of America 115, no. 10 (March 2018): E2165–74. https://doi.org/10.1073/pnas.1714873115.
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    • Cao, Jingli, Jinhu Wang, Christopher P. Jackman, Amanda H. Cox, Michael A. Trembley, Joseph J. Balowski, Ben D. Cox, et al. “Tension Creates an Endoreplication Wavefront that Leads Regeneration of Epicardial Tissue..” Developmental Cell 42, no. 6 (September 2017): 600-615.e4. https://doi.org/10.1016/j.devcel.2017.08.024.
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    • Ferree, Patrick L., and Stefano Di Talia. “For Embryos, Mother Can Only Take You So Far..” Developmental Cell 42, no. 3 (August 2017): 203–5. https://doi.org/10.1016/j.devcel.2017.07.016.
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    • Tornini, Valerie A., Alberto Puliafito, Leslie A. Slota, John D. Thompson, Gregory Nachtrab, Anna-Lila Kaushik, Marika Kapsimali, Luca Primo, Stefano Di Talia, and Kenneth D. Poss. “Live Monitoring of Blastemal Cell Contributions during Appendage Regeneration..” Current Biology : Cb 26, no. 22 (November 10, 2016): 2981–91. https://doi.org/10.1016/j.cub.2016.08.072.
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    • Di Talia, Stefano, and Kenneth D. Poss. “Monitoring Tissue Regeneration at Single-Cell Resolution..” Cell Stem Cell 19, no. 4 (October 2016): 428–31. https://doi.org/10.1016/j.stem.2016.09.007.
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    • Momen-Roknabadi, Amir, Stefano Di Talia, and Eric Wieschaus. “Transcriptional Timers Regulating Mitosis in Early Drosophila Embryos..” Cell Reports 16, no. 11 (September 2016): 2793–2801. https://doi.org/10.1016/j.celrep.2016.08.034.
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    • Deneke, Victoria E., Anna Melbinger, Massimo Vergassola, and Stefano Di Talia. “Waves of Cdk1 Activity in S Phase Synchronize the Cell Cycle in Drosophila Embryos..” Developmental Cell 38, no. 4 (August 2016): 399–412. https://doi.org/10.1016/j.devcel.2016.07.023.
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    • Ferree, Patrick L., Victoria E. Deneke, and Stefano Di Talia. “Measuring time during early embryonic development..” Seminars in Cell & Developmental Biology 55 (July 2016): 80–88. https://doi.org/10.1016/j.semcdb.2016.03.013.
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    • Chen, Chen-Hui, Alberto Puliafito, Ben D. Cox, Luca Primo, Yi Fang, Stefano Di Talia, and Kenneth D. Poss. “Multicolor Cell Barcoding Technology for Long-Term Surveillance of Epithelial Regeneration in Zebrafish..” Dev Cell 36, no. 6 (March 21, 2016): 668–80. https://doi.org/10.1016/j.devcel.2016.02.017.
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    • Xenopoulos, Panagiotis, Minjung Kang, Alberto Puliafito, Stefano Di Talia, and Anna-Katerina Hadjantonakis. “Heterogeneities in Nanog Expression Drive Stable Commitment to Pluripotency in the Mouse Blastocyst..” Cell Reports 10, no. 9 (March 5, 2015): 1508–20. https://doi.org/10.1016/j.celrep.2015.02.010.
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    • Di Talia, Stefano, and Eric F. Wieschaus. “Simple biochemical pathways far from steady state can provide switchlike and integrated responses..” Biophysical Journal 107, no. 3 (August 2014): L1–4. https://doi.org/10.1016/j.bpj.2014.06.018.
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    • Schrode, Nadine, Néstor Saiz, Stefano Di Talia, and Anna-Katerina Hadjantonakis. “GATA6 levels modulate primitive endoderm cell fate choice and timing in the mouse blastocyst..” Developmental Cell 29, no. 4 (May 15, 2014): 454–67. https://doi.org/10.1016/j.devcel.2014.04.011.
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    • Di Talia, Stefano, Richard She, Shelby A. Blythe, Xuemin Lu, Qi Fan Zhang, and Eric F. Wieschaus. “Posttranslational control of Cdc25 degradation terminates Drosophila's early cell-cycle program..” Current Biology : Cb 23, no. 2 (January 3, 2013): 127–32. https://doi.org/10.1016/j.cub.2012.11.029.
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    • Di Talia, Stefano, and Eric F. Wieschaus. “Short-term integration of Cdc25 dynamics controls mitotic entry during Drosophila gastrulation..” Developmental Cell 22, no. 4 (April 5, 2012): 763–74. https://doi.org/10.1016/j.devcel.2012.01.019.
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    • Zilman, Anton, Stefano Di Talia, Tijana Jovanovic-Talisman, Brian T. Chait, Michael P. Rout, and Marcelo O. Magnasco. “Enhancement of transport selectivity through nano-channels by non-specific competition..” Plos Computational Biology 6, no. 6 (June 10, 2010). https://doi.org/10.1371/journal.pcbi.1000804.
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    • Zilman, A., S. D. Talia, T. Jovanovic-Talisman, B. T. Chait, M. P. Rout, and M. O. Magnasco. “Enhancement of transport selectivity through nano-channels by non-specific competition..” Plos Computational Biology 6, no. 6 (2010). https://doi.org/10.1371/journal.pcbi.1000804.
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    • Di Talia, Stefano, Hongyin Wang, Jan M. Skotheim, Adam P. Rosebrock, Bruce Futcher, and Frederick R. Cross. “Daughter-specific transcription factors regulate cell size control in budding yeast..” Plos Biology 7, no. 10 (October 20, 2009). https://doi.org/10.1371/journal.pbio.1000221.
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    • Skotheim, Jan M., Stefano Di Talia, Eric D. Siggia, and Frederick R. Cross. “Positive feedback of G1 cyclins ensures coherent cell cycle entry..” Nature 454, no. 7202 (July 2008): 291–96. https://doi.org/10.1038/nature07118.
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    • Di Talia, S., J. M. Skotheim, J. M. Bean, E. D. Siggia, and F. R. Cross. “The effects of molecular noise and size control on variability in the budding yeast cell cycle (Nature (2007) 448, (947-951)).” Nature 450, no. 7173 (December 20, 2007). https://doi.org/10.1038/nature06511.
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    • Di Talia, Stefano, Jan M. Skotheim, James M. Bean, Eric D. Siggia, and Frederick R. Cross. “The effects of molecular noise and size control on variability in the budding yeast cell cycle..” Nature 448, no. 7156 (August 2007): 947–51. https://doi.org/10.1038/nature06072.
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    • Zilman, Anton, Stefano Di Talia, Brian T. Chait, Michael P. Rout, and Marcelo O. Magnasco. “Efficiency, selectivity, and robustness of nucleocytoplasmic transport..” Plos Computational Biology 3, no. 7 (July 2007). https://doi.org/10.1371/journal.pcbi.0030125.
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    • Candia, Antonio de, Andrea Gamba, Fausto Cavalli, Antonio Coniglio, Stefano Di Talia, Federico Bussolino, and Guido Serini. “A simulation environment for directional sensing as a phase separation process..” Science’S Stke : Signal Transduction Knowledge Environment 2007, no. 378 (March 20, 2007). https://doi.org/10.1126/stke.3782007pl1.
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    • Zilman, A., S. D. Talia, B. T. Chait, M. P. Rout, and M. O. Magnasco. “Efficiency, selectivity, and robustness of nucleocytoplasmic transport..” Plos Computational Biology 3, no. 7 (2007). https://doi.org/10.1371/journal.pcbi.0030125.
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    • Di Talia, S., A. Gamba, F. Lamberti, and G. Serini. “Role of repulsive factors in vascularization dynamics.” Physical Review E  Statistical, Nonlinear, and Soft Matter Physics 73, no. 4 (April 21, 2006). https://doi.org/10.1103/PhysRevE.73.041917.
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    • Di Talia, S., A. Gamba, F. Lamberti, and G. Serini. “Role of repulsive factors in vascularization dynamics..” Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics 73, no. 4 Pt 1 (April 14, 2006). https://doi.org/10.1103/physreve.73.041917.
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    • Gamba, Andrea, Antonio de Candia, Stefano Di Talia, Antonio Coniglio, Federico Bussolino, and Guido Serini. “Diffusion-limited phase separation in eukaryotic chemotaxis..” Proceedings of the National Academy of Sciences of the United States of America 102, no. 47 (November 16, 2005): 16927–32. https://doi.org/10.1073/pnas.0503974102.
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    • Coniglio, A., A. De Candia, S. Di Talia, and A. Gamba. “Erratum: Percolation and Burgers' dynamics in a model of capillary formation (Physical Review E (2004) 69 (051910)).” Physical Review E  Statistical, Nonlinear, and Soft Matter Physics 70, no. 3 2 (September 1, 2004): 039902–039901. https://doi.org/10.1103/PhysRevE.70.039902.
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    • Coniglio, A., A. de Candia, S. Di Talia, and A. Gamba. “Percolation and Burgers' dynamics in a model of capillary formation..” Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics 69, no. 5 Pt 1 (May 24, 2004). https://doi.org/10.1103/physreve.69.051910.
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    • Coniglio, A., A. De Candia, S. Di Talia, and A. Gamba. “Percolation and Burgers' dynamics in a model of capillary formation.” Physical Review E  Statistical, Nonlinear, and Soft Matter Physics 69, no. 5 2 (January 1, 2004).
    • Coniglio, A., A. de Candia, S. Di Talia, and A. Gamba. “Percolation and Burgers’ dynamics in a model of capillary formation.” Physical Review E  Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics 69, no. 5 (January 1, 2004). https://doi.org/10.1103/PhysRevE.69.051910.
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    • Gamba, A., D. Ambrosi, A. Coniglio, A. de Candia, S. Di Talia, E. Giraudo, G. Serini, L. Preziosi, and F. Bussolino. “Percolation, morphogenesis, and burgers dynamics in blood vessels formation..” Physical Review Letters 90, no. 11 (March 17, 2003). https://doi.org/10.1103/physrevlett.90.118101.
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  • Conference Papers

    • Deneke, V., M. Vergassola, A. Puliafito, and S. Di Talia. “Physical and molecular mechanisms of cell cycle synchronization in early Drosophila embryos..” In Molecular Biology of the Cell, Vol. 28. AMER SOC CELL BIOLOGY, 2017.
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    • Falahati, H., S. Di Talia, and E. Wieschaus. “Temperature-induced uncoupling of cell cycle regulatory mechanisms..” In Molecular Biology of the Cell, Vol. 28. AMER SOC CELL BIOLOGY, 2017.
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    • Saiz, N., M. Kang, A. Puliafito, N. Schrode, P. Xenopoulos, X. Lou, S. Di Talia, and A. K. Hadjantonakis. “Quantitative analyses for elucidating mechanisms of cell fate commitment in the mouse blastocyst.” In Progress in Biomedical Optics and Imaging  Proceedings of Spie, Vol. 9334, 2015. https://doi.org/10.1117/12.2081232.
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    • Roknabadi, A Momen, S. Di Talia, and E. Wieschaus. “Studying The Regulation of Temporal Patterning of String Transcription in Early Drosophila Cell Cycles..” In Molecular Biology of the Cell, Vol. 25. AMER SOC CELL BIOLOGY, 2014.
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    • Gamba, A., A. De Candia, S. Di Talia, A. Coniglio, F. Bussolino, and G. Serini. “Phase separation in eukaryotic directional sensing,” 38:23–32, 2007. https://doi.org/10.1007/978-0-8176-4558-8_3.
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    • Gamba, A., A. De Candia, F. Cavalli, S. Di Talia, A. Coniglio, F. Bussolino, and G. Serini. “A computational model for eukaryotic directional sensing.” In Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), 4210 LNBI:184–95, 2006.
• Teaching & Mentoring
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  Recent Courses

  • CELLBIO 493: Research Independent Study 2019
  • CMB 640: Quantitative Approaches to Biological Problems: From Cartoon Models to System Behavior 2019
  • CMB 710E: Cell & Molecular Biology Module V 2019
  • UPGEN 640: Quantitative Approaches to Biological Problems: From Cartoon Models to System Behavior 2019
  • CMB 710B: Cell & Molecular Biology Module II 2018
  • UPGEN 716S: Genetics Student Research 2017

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