Stephen Joseph Balevic | Scholars@Duke

Stephen Joseph Balevic
Assistant Professor of Pediatrics

I am an Adult and Pediatric Rheumatologist and care for patients with a wide variety of autoimmune and rheumatic diseases, including: systemic lupus, rheumatoid arthritis, juvenile arthritis, vasculitis, and sarcoidosis, among others. I have a special interest in using musculoskeletal ultrasound to optimize diagnosis and treatment decisions at the bedside.

I am also a clinical researcher at the Duke Clinical Research Institute (DCRI). My research interests are in clinical trials and precision medicine through population pharmacokinetic/pharmacodynamic modeling. I completed my clinical and research fellowships as well as a Master of Health Science Degree in Clinical Research at Duke University. I completed clinical pharmacology training though the NICHD sponsored, UNC-Duke Clinical Pharmacology T32 Training Program. I serve as the principal investigator on several foundation grants studying hydroxychloroquine and azathioprine pharmacokinetics and exposure-response in lupus, as well as principal investigator or co-investigator for several clinical trials at the DCRI.

Current Appointments & Affiliations

Assistant Professor of Pediatrics, Pediatrics, Rheumatology, Pediatrics 2021
Assistant Professor of Medicine, Medicine, Rheumatology and Immunology, Medicine 2018
Member of the Duke Clinical Research Institute, Duke Clinical Research Institute, Institutes and Centers 2018

Contact Information

stephen.balevic@duke.edu

Background
Education, Training, & Certifications
- Clinical Research Fellow, Dcri, Duke University School of Medicine 2016 - 2018
- Clinical Pharmacology Fellowship, Duke And Unc School Of Pharmacy, Duke University School of Medicine 2016 - 2018
- Fellowship Adult and Pediatric, Pediatrics, Duke University School of Medicine 2014 - 2018
- Internal Medicine and Pediatric Residency, Medical University of South Carolina, School of Medicine 2010 - 2014
- M.D., Marshall University 2010
Duke Appointment History
- Assistant Professor of Pediatrics, Pediatrics, Rheumatology, Pediatrics 2018 - 2020
Recognition
In the News
- SEP 22, 2020 DCRI Pulse
  
  DCRI Launches First Direct-to-Family Study
Research
Selected Grants
- Optimal Dosing for Biologic Agents in Obese Patients with Rheumatoid and Juvenile Arthritis awarded by National Institutes of Health 2020 - 2025
- Optimizing Hydroxychloroquine to Reduce Disease Activity in Pediatric Lupus awarded by Thrasher Research Fund 2021 - 2022
- PTN2- TO# BPCA Pharmacology Studies awarded by National Institute for Child Health & Human Develo 2018 - 2022
- Global Pediatric Clinical Trials Network awarded by Food and Drug Administration 2017 - 2022
- RTOP 18-0006 Option 1 / Protocol Implementation awarded by National Institute of Allergy and Infectious Diseases 2019 - 2022
- Center for Innovative TRIals in ChilDrEN and AdulTs (TRIDENT) awarded by National Institutes of Health 2016 - 2021
- RTOP 18-0006 Option 1 / Protocol Implementation awarded by National Institute of Allergy and Infectious Diseases 2019 - 2021
- HCQ Pharmacokinetics in Pediatric Lupus awarded by Childhood Arthritis & Rheumatology Research Alliance, Inc. 2019 - 2020
- PTN2- TO# Data Closeout and Dissemination awarded by National Institute for Child Health & Human Develo 2018 - 2019
- ACR/Amgen Rheumatology Fellowship Training Award awarded by Rheumatology Research Foundation 2015 - 2016
External Relationships
- UCB
- US Food and Drug Administration
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Rajendran, Aardra, Amanda M. Eudy, Stephen J. Balevic, and Megan E. B. Clowse. “The importance of pregnancy planning in lupus pregnancies.” Lupus, January 28, 2021, 961203321989803. https://doi.org/10.1177/0961203321989803.
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  - Udupa, Akrithi, David Leverenz, Stephen J. Balevic, Rebecca E. Sadun, Teresa K. Tarrant, and Jennifer L. Rogers. “Hydroxychloroquine and COVID-19: a Rheumatologist's Take on the Lessons Learned.” Curr Allergy Asthma Rep 21, no. 1 (January 21, 2021): 5. https://doi.org/10.1007/s11882-020-00983-9.
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  - Balevic, Stephen J., Lindsay Singler, Rachel Randell, Richard J. Chung, Monica E. Lemmon, and Christoph P. Hornik. “Bringing research directly to families in the era of COVID-19.” Pediatr Res, November 11, 2020. https://doi.org/10.1038/s41390-020-01260-1.
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  - Balevic, Stephen J., Christoph P. Hornik, Thomas P. Green, Megan E. B. Clowse, Daniel Gonzalez, Anil R. Maharaj, Laura E. Schanberg, et al. “Dr. Balevic, et al reply.” J Rheumatol 47, no. 10 (October 1, 2020): 1587. https://doi.org/10.3899/jrheum.200681.
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  - Maharaj, Anil R., Huali Wu, Christoph P. Hornik, Stephen J. Balevic, Chi D. Hornik, P Brian Smith, Daniel Gonzalez, et al. “Simulated Assessment of Pharmacokinetically Guided Dosing for Investigational Treatments of Pediatric Patients With Coronavirus Disease 2019.” Jama Pediatr 174, no. 10 (October 1, 2020): e202422. https://doi.org/10.1001/jamapediatrics.2020.2422.
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  - Balevic, Stephen J., Christoph P. Hornik, Thomas P. Green, Megan E. B. Clowse, Daniel Gonzalez, Anil R. Maharaj, Laura E. Schanberg, et al. “Hydroxychloroquine in Patients with Rheumatic Disease Complicated by COVID-19: Clarifying Target Exposures and the Need for Clinical Trials.” J Rheumatol, May 11, 2020. https://doi.org/10.3899/jrheum.200493.
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  - Dallefeld, S. H., P. B. Smith, E. G. Crenshaw, K. R. Daniel, M. L. Gilleskie, D. S. Smith, S. Balevic, et al. “Comparative safety profile of chloral hydrate versus other sedatives for procedural sedation in hospitalized infants.” J Neonatal Perinatal Med 13, no. 2 (2020): 159–65. https://doi.org/10.3233/NPM-190214.
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  - Thompson, Elizabeth J., Huali Wu, Chiara Melloni, Stephen Balevic, Janice E. Sullivan, Matthew Laughon, Kira M. Clark, et al. “Population Pharmacokinetics of Doxycycline in Children.” Antimicrob Agents Chemother, September 23, 2019. https://doi.org/10.1128/AAC.01508-19.
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  - Balevic, Stephen J., P Brian Smith, Daniela Testoni, Huali Wu, Kim L. R. Brouwer, Kanecia O. Zimmerman, Nazario D. Rivera-Chaparro, Daniel K. Benjamin, and Michael Cohen-Wolkowiez. “Cefazolin pharmacokinetics in premature infants.” J Perinatol 39, no. 9 (September 2019): 1213–18. https://doi.org/10.1038/s41372-019-0368-z.
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  - Thompson, Elizabeth J., Huali Wu, Anil Maharaj, Andrea N. Edginton, Stephen J. Balevic, Marjan Cobbaert, Anthony P. Cunningham, Christoph P. Hornik, and Michael Cohen-Wolkowiez. “Physiologically Based Pharmacokinetic Modeling for Trimethoprim and Sulfamethoxazole in Children.” Clin Pharmacokinet 58, no. 7 (July 2019): 887–98. https://doi.org/10.1007/s40262-018-00733-1.
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  - Watt, Kevin M., Christoph P. Hornik, Stephen J. Balevic, Gratias Mundakel, C Michael Cotten, Barrie Harper, Daniel K. Benjamin, et al. “Pharmacokinetics of ticarcillin-clavulanate in premature infants.” Br J Clin Pharmacol 85, no. 5 (May 2019): 1021–27. https://doi.org/10.1111/bcp.13882.
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  - Balevic, Stephen J., Thomas P. Green, Megan E. B. Clowse, Amanda M. Eudy, Laura E. Schanberg, and Michael Cohen-Wolkowiez. “Pharmacokinetics of Hydroxychloroquine in Pregnancies with Rheumatic Diseases.” Clin Pharmacokinet 58, no. 4 (April 2019): 525–33. https://doi.org/10.1007/s40262-018-0712-z.
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  - Balevic, Stephen J., Michael Cohen-Wolkowiez, Amanda M. Eudy, Thomas P. Green, Laura E. Schanberg, and Megan E. B. Clowse. “Hydroxychloroquine Levels throughout Pregnancies Complicated by Rheumatic Disease: Implications for Maternal and Neonatal Outcomes.” J Rheumatol 46, no. 1 (January 2019): 57–63. https://doi.org/10.3899/jrheum.180158.
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  - Balevic, Stephen J., and Michael Cohen-Wolkowiez. “Innovative Study Designs Optimizing Clinical Pharmacology Research in Infants and Children.” J Clin Pharmacol 58 Suppl 10 (October 2018): S58–72. https://doi.org/10.1002/jcph.1053.
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  - Wang, Laura A., P Brian Smith, Matthew Laughon, Ronald N. Goldberg, Lawrence C. Ku, Kanecia O. Zimmerman, Stephen Balevic, et al. “Prolonged furosemide exposure and risk of abnormal newborn hearing screen in premature infants.” Early Hum Dev 125 (October 2018): 26–30. https://doi.org/10.1016/j.earlhumdev.2018.08.009.
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  - Mater, Heather van, Stephen J. Balevic, Gary L. Freed, and Sarah J. Clark. “Prescribing for Children With Rheumatic Disease: Perceived Treatment Approaches Between Pediatric and Adult Rheumatologists.” Arthritis Care Res (Hoboken) 70, no. 2 (February 2018): 268–74. https://doi.org/10.1002/acr.23273.
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  - Sadun, Rebecca E., Melissa A. Wells, Stephen J. Balevic, Victoria Lackey, Erica J. Aldridge, Nicholas Holdgagte, Samya Mohammad, Lisa G. Criscione-Schreiber, Megan E. B. Clowse, and Mamata Yanamadala. “Increasing contraception use among women receiving teratogenic medications in a rheumatology clinic.” Bmj Open Qual 7, no. 3 (2018): e000269. https://doi.org/10.1136/bmjoq-2017-000269.
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  - Balevic, Stephen J., Mara L. Becker, Michael Cohen-Wolkowiez, and Laura E. Schanberg. “Clinical Trial Design in Juvenile Idiopathic Arthritis.” Paediatr Drugs 19, no. 5 (October 2017): 379–89. https://doi.org/10.1007/s40272-017-0244-2.
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  - Balevic, Stephen J., and Ankoor Shah. “Islands of Inflammation: Neurosarcoidosis.” Am J Med 130, no. 2 (February 2017): 157–60. https://doi.org/10.1016/j.amjmed.2016.09.009.
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  - Balevic, Stephen J., and C Egla Rabinovich. “Profile of adalimumab and its potential in the treatment of uveitis.” Drug Des Devel Ther 10 (2016): 2997–3003. https://doi.org/10.2147/DDDT.S94188.
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  - Balevic, Stephen, Michael Taylor, and Michelle Amaya. “Penile and scrotal swelling mimicking child abuse.” Clin Pediatr (Phila) 52, no. 10 (October 2013): 988–90. https://doi.org/10.1177/0009922813497826.
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Education, Training, & Certifications

Duke Appointment History

In the News

Selected Grants

External Relationships

Selected Publications

Academic Articles