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Stephen Joseph Balevic

Associate Professor of Pediatrics
Pediatrics, Rheumatology
2301 Erwin Rd, Durham, NC 27710
2301 Erwin Rd, Durham, NC 27710

Overview


I am an Adult and Pediatric Rheumatologist and care for patients with a wide variety of autoimmune and rheumatic diseases, including: systemic lupus, rheumatoid arthritis, juvenile arthritis, vasculitis, and sarcoidosis, among others. I have a special interest in using musculoskeletal ultrasound to optimize diagnosis and treatment decisions at the bedside.

I am also a clinical researcher at the Duke Clinical Research Institute (DCRI). My research interests are in clinical trials and precision medicine through population pharmacokinetic/pharmacodynamic modeling. I obtained my PhD in Pharmaceutical Sciences from the UNC Eshelman School of Pharmacy. I serve as the principal investigator on several grants studying hydroxychloroquine and azathioprine pharmacokinetics and exposure-response in lupus, as well as principal investigator or co-investigator for several clinical trials at the DCRI. Additionally, I am an Assistant Scientific Director for the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry- the largest registry of children with rheumatic diseases in North America.

Current Appointments & Affiliations


Associate Professor of Pediatrics · 2022 - Present Pediatrics, Rheumatology, Pediatrics
Associate Professor of Medicine · 2022 - Present Medicine, Rheumatology and Immunology, Medicine
Member in the Duke Clinical Research Institute · 2018 - Present Duke Clinical Research Institute, Institutes and Centers

In the News


Published September 22, 2020
DCRI Launches First Direct-to-Family Study

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Recent Publications


Second (2nd) Trimester Kidney Function and Adverse Pregnancy Outcomes among Patients with Lupus.

Journal Article Kidney360 · February 14, 2025 BACKGROUND: Kidney function is not routinely assessed during pregnancy. Several studies have proposed antepartum kidney function, particularly 2nd trimester kidney function, as a potential predictor of adverse pregnancy outcomes. It has been previously est ... Full text Link to item Cite

Population Pharmacokinetics of Meropenem Across the Adult Lifespan.

Journal Article Clin Pharmacokinet · February 2025 BACKGROUND AND OBJECTIVE: We conducted an opportunistic pharmacokinetic study to evaluate the population pharmacokinetics of meropenem, an antimicrobial commonly used to treat Gram-negative infections in adults of different ages, including older adults, an ... Full text Link to item Cite

Complement factor H targeting antibody GT103 in refractory non-small cell lung cancer: a phase 1b dose escalation trial.

Journal Article Nat Commun · January 2, 2025 GT103 is a first-in-class, fully human, IgG3 monoclonal antibody targeting complement factor H that kills tumor cells and promotes anti-cancer immunity in preclinical models. We conducted a first-in-human phase 1b study dose escalation trial of GT103 in re ... Full text Open Access Link to item Cite
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Recent Grants


PTN 2.0 TO #11: CUDDLE 2.0

ResearchCo Investigator · Awarded by National Institutes of Health · 2021 - 2026

Duke-UNC Collaborative Pediatric Clinical Pharmacology Postdoctoral Training Program

Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2021 - 2026

BPCA Data Closeout, Results Dissemination, And Stakeholder Engagement (Version 2.0)

ResearchPrincipal Investigator · Awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development · 2023 - 2025

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Education, Training & Certifications


University of North Carolina, Chapel Hill · 2022 Ph.D.
Duke University, School of Medicine · 2018 M.H.S.
Marshall University · 2010 M.D.