Overview
I am an Adult and Pediatric Rheumatologist and care for patients with a wide variety of autoimmune and rheumatic diseases, including: systemic lupus, rheumatoid arthritis, juvenile arthritis, vasculitis, and sarcoidosis, among others. I have a special interest in using musculoskeletal ultrasound to optimize diagnosis and treatment decisions at the bedside.
I am also a clinical researcher at the Duke Clinical Research Institute (DCRI). My research interests are in clinical trials and precision medicine through population pharmacokinetic/pharmacodynamic modeling. I obtained my PhD in Pharmaceutical Sciences from the UNC Eshelman School of Pharmacy. I serve as the principal investigator on several grants studying hydroxychloroquine and azathioprine pharmacokinetics and exposure-response in lupus, as well as principal investigator or co-investigator for several clinical trials at the DCRI. Additionally, I am an Assistant Scientific Director for the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry- the largest registry of children with rheumatic diseases in North America.
I am also a clinical researcher at the Duke Clinical Research Institute (DCRI). My research interests are in clinical trials and precision medicine through population pharmacokinetic/pharmacodynamic modeling. I obtained my PhD in Pharmaceutical Sciences from the UNC Eshelman School of Pharmacy. I serve as the principal investigator on several grants studying hydroxychloroquine and azathioprine pharmacokinetics and exposure-response in lupus, as well as principal investigator or co-investigator for several clinical trials at the DCRI. Additionally, I am an Assistant Scientific Director for the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry- the largest registry of children with rheumatic diseases in North America.
Current Appointments & Affiliations
Associate Professor of Pediatrics
·
2022 - Present
Pediatrics, Rheumatology,
Pediatrics
Associate Professor of Medicine
·
2022 - Present
Medicine, Rheumatology and Immunology,
Medicine
Member in the Duke Clinical Research Institute
·
2018 - Present
Duke Clinical Research Institute,
Institutes and Centers
Recent Publications
Second (2nd) Trimester Kidney Function and Adverse Pregnancy Outcomes among Patients with Lupus.
Journal Article Kidney360 · February 14, 2025 BACKGROUND: Kidney function is not routinely assessed during pregnancy. Several studies have proposed antepartum kidney function, particularly 2nd trimester kidney function, as a potential predictor of adverse pregnancy outcomes. It has been previously est ... Full text Link to item CitePopulation Pharmacokinetics of Meropenem Across the Adult Lifespan.
Journal Article Clin Pharmacokinet · February 2025 BACKGROUND AND OBJECTIVE: We conducted an opportunistic pharmacokinetic study to evaluate the population pharmacokinetics of meropenem, an antimicrobial commonly used to treat Gram-negative infections in adults of different ages, including older adults, an ... Full text Link to item CiteComplement factor H targeting antibody GT103 in refractory non-small cell lung cancer: a phase 1b dose escalation trial.
Journal Article Nat Commun · January 2, 2025 GT103 is a first-in-class, fully human, IgG3 monoclonal antibody targeting complement factor H that kills tumor cells and promotes anti-cancer immunity in preclinical models. We conducted a first-in-human phase 1b study dose escalation trial of GT103 in re ... Full text Open Access Link to item CiteRecent Grants
PTN 2.0 TO #11: CUDDLE 2.0
ResearchCo Investigator · Awarded by National Institutes of Health · 2021 - 2026Duke-UNC Collaborative Pediatric Clinical Pharmacology Postdoctoral Training Program
Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2021 - 2026BPCA Data Closeout, Results Dissemination, And Stakeholder Engagement (Version 2.0)
ResearchPrincipal Investigator · Awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development · 2023 - 2025View All Grants
Education, Training & Certifications
University of North Carolina, Chapel Hill ·
2022
Ph.D.
Duke University, School of Medicine ·
2018
M.H.S.
Marshall University ·
2010
M.D.