Current Appointments & Affiliations
Professor of Pediatrics
·
2026 - Present
Pediatrics, Transplant and Cellular Therapy,
Pediatrics
Professor in Pharmacology and Cancer Biology
·
2026 - Present
Pharmacology & Cancer Biology,
Basic Science Departments
Member of the Duke Cancer Institute
·
2024 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Publications
An imbalance between proliferation and differentiation underlies the development of microRNA-defective pineoblastoma.
Journal Article Genes Dev · June 2, 2025 Mutations in the microRNA processing genes DROSHA and DICER1 drive several cancers that resemble embryonic progenitors. To understand how microRNAs regulate tumorigenesis, we ablated Drosha or Dicer1 in the developing pineal gland to emulate the pathogenes ... Full text Link to item CiteA Novel Approach to Harnessing Acoustic A-Lines to Detect Circulating Tumor Cells in Flowing Blood.
Journal Article Nano Lett · December 11, 2024 Circulating tumor cells (CTCs) are associated with tumor burden and treatment response and, as hallmarks of the initiation of tumor dissemination, can predict the likelihood of metastatic progression before widespread tumors can be detected by standard ana ... Full text Link to item CiteGermline Genetic Testing and Survival Outcomes Among Children With Rhabdomyosarcoma: A Report From the Children's Oncology Group.
Journal Article JAMA Netw Open · March 4, 2024 IMPORTANCE: Determining the impact of germline cancer-predisposition variants (CPVs) on outcomes could inform novel approaches to testing and treating children with rhabdomyosarcoma. OBJECTIVE: To assess whether CPVs are associated with outcome among child ... Full text Link to item CiteRecent Grants
Evaluation of FANCM as a specific dependency in PAX3::FOXO1 rhabdomyosarcoma
ResearchPrincipal Investigator · Awarded by Hyundai Hope on Wheels · 2025 - 2027Liquid biopsy approaches to inform neuroblastoma prognosis and disease monitoring
ResearchPrincipal Investigator · Awarded by University of Chicago · 2024 - 2027A multi-pronged approach to pediatric cancer: research, psychosocial and neuropsychological support
Institutional SupportPrincipal Investigator · Awarded by Hyundai Hope on Wheels · 2026 - 2026View All Grants
Education, Training & Certifications
Duke University, School of Medicine ·
1988
M.D.
Duke University ·
1984
B.A.