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Stephen William Smith

Professor Emeritus of Biomedical Engineering
Biomedical Engineering
Box 90281, 1427 Fciemas, Durham, NC 27708-0281
1427 Fciemas, 101 Science Drive, Durham, NC 27708

Overview


Current research interests are the development and evaluation of improved medical ultrasound image quality for applications in cardiology, radiology and obstetrics. Advances in image quality result from improvements in the spatial resolution and signal-to-noise ratio of diagnostic ultrasound scanners through novel signal processing techniques and improved design of ultrasound transducers.

One current project includes the development of two-dimensional phased array transducers for application in the Duke 3-D ultrasound scanner in these N x N, "checkerboard'' arrays are used to steer the ultrasound beam in both the azimuth and elevation directions within the patient's body to interrogate a pyramidal shaped object and produce a volumetric scan at high speeds without moving the transducer.

Recently developed transducers include 100 x 100 = 10,000 element arrays operating at 5-10 MHz. Each square element is only 0.2 mm on a side. In addition, we have developed such 2D arrays to fit inside of intra-cardiac catheters only 2 mm in diameter for guidance of cardiac interventional procedures such as mapping and ablation of atrial fibrillation. Processing technologies include the use of micro electronic packaging and fabrication techniques to develop higher frequency arrays up to 20 MHz with improved resolution and smaller element sizes down to 0.05 mm.

Current Appointments & Affiliations


Professor Emeritus of Biomedical Engineering · 2017 - Present Biomedical Engineering, Pratt School of Engineering

Recent Publications


Double Ring Array Catheter for In Vivo Real-Time 3D Ultrasound.

Journal Article Ultrasonic imaging · July 2014 We developed new forward-viewing matrix transducers consisting of double ring arrays of 118 total PZT elements integrated into catheters used to deploy medical interventional devices. Our goal is 3D ultrasound guidance of medical device implantation to red ... Full text Cite

Acoustic radiation force impulse imaging (ARFI) on an IVUS circular array.

Journal Article Ultrasonic imaging · April 2014 Our long-term goal is the detection and characterization of vulnerable plaque in the coronary arteries of the heart using intravascular ultrasound (IVUS) catheters. Vulnerable plaque, characterized by a thin fibrous cap and a soft, lipid-rich necrotic core ... Full text Open Access Cite

3-D transcranial ultrasound imaging with bilateral phase aberration correction of multiple isoplanatic patches: a pilot human study with microbubble contrast enhancement.

Journal Article Ultrasound Med Biol · January 2014 With stroke currently the second-leading cause of death globally, and 87% of all strokes classified as ischemic, the development of a fast, accessible, cost-effective approach for imaging occlusive stroke could have a significant impact on health care outc ... Full text Link to item Cite
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Recent Grants


3D Ultrasound Guidance of Interventional Devices

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2008 - 2014

Cross-disciplinary Training in Medical Physics

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2007 - 2013

New Scanning Modalities for 3-D Cardiac Ultrasound

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2003 - 2008

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Education, Training & Certifications


Duke University · 1975 Ph.D.
Iowa State University · 1969 M.S.
Thomas More College · 1967 B.A.