Steven Sok Choi
Associate Professor of Medicine
Hepatic stellate cell biology; Hepatic Fibrogenesis; Liver regeneration
Current Appointments & Affiliations
- Associate Professor of Medicine, Medicine, Gastroenterology, Medicine 2021
Contact Information
- Durham VA Medical Center, 508 Fulton Street, 111E, Gi Clinic, Durham, NC 27705
- Durham VA Medical Center, 508 Fulton Street, 111E, Gi Clinic, Durham, NC 27705
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(919) 286-6945
- Background
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Education, Training, & Certifications
- Fellow in Gastroenterology, Medicine, Duke University 2004 - 2007
- Medical Resident, Medicine, Duke University 2001 - 2004
- M.B.B.S., Flinders University (Australia) 1999
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Previous Appointments & Affiliations
- Associate Professor of Medicine, Medicine, Gastroenterology, Medicine 2017 - 2020
- Assistant Professor of Medicine, Medicine, Gastroenterology, Medicine 2016 - 2017
- Assistant Professor of Medicine, Medicine, Gastroenterology, Medicine 2008 - 2016
- Medical Instructor in the Department of Medicine, Medicine, Gastroenterology, Medicine 2007 - 2008
- Expertise
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Subject Headings
- ATP Binding Cassette Transporter, Sub-Family B
- Actins
- Acute Disease
- Adipokines
- Adult
- Adult Stem Cells
- Age Factors
- Aged
- Alphavirus Infections
- Animals
- Antibodies
- Antigens, Viral
- Antiviral Agents
- Apoptosis
- Aspartate Aminotransferases
- Autocrine Communication
- Bile
- Bile Ducts
- Bile Ducts, Intrahepatic
- Biliary Atresia
- Biological Markers
- Biopsy
- Blotting, Western
- Calcium-Binding Proteins
- Carbon Tetrachloride
- Carcinogenesis
- Carcinoma, Hepatocellular
- Caspase 3
- Caspase Inhibitors
- Cell Aging
- Cell Communication
- Cell Count
- Cell Death
- Cell Differentiation
- Cell Line
- Cell Line, Tumor
- Cell Lineage
- Cell Movement
- Cell Nucleus
- Cell Proliferation
- Cell Survival
- Cell Transdifferentiation
- Cell-Derived Microparticles
- Cells, Cultured
- Chemical and Drug Induced Liver Injury
- Chemokines, CXC
- Chemotaxis
- Child, Preschool
- Cholestasis
- Cholestasis, Intrahepatic
- Chronic Disease
- Coculture Techniques
- Collagen
- Cytochrome P-450 CYP2E1
- Cytokines
- Diacylglycerol O-Acyltransferase
- Diagnosis, Differential
- Disease Models, Animal
- Disease Progression
- Down-Regulation
- Endoplasmic Reticulum
- Endothelial Cells
- Enzyme Inhibitors
- Enzyme-Linked Immunosorbent Assay
- Epithelial Cells
- Epithelial-Mesenchymal Transition
- Ethanol
- Fatty Liver
- Fatty Liver, Alcoholic
- Female
- Fibroblasts
- Fibrosis
- Foot
- Gene Expression
- Gene Expression Regulation, Developmental
- Gene Expression Regulation, Neoplastic
- Gene Silencing
- Genotype
- Glycolysis
- Hedgehog Proteins
- Hep G2 Cells
- Hepacivirus
- Hepatectomy
- Hepatic Stellate Cells
- Hepatitis B, Chronic
- Hepatitis C, Chronic
- Hepatitis Viruses
- Hepatocyte Nuclear Factor 6
- Histocompatibility Antigens
- Humans
- Hybridomas
- Hydroxyproline
- Hypertension, Portal
- Hypoxia-Inducible Factor 1, alpha Subunit
- I-kappa B Kinase
- Inflammation
- Insulin Resistance
- Intercellular Signaling Peptides and Proteins
- Interferon-alpha
- Interferon-gamma
- Interleukin-13
- Interleukin-4
- Ki-67 Antigen
- Lactic Acid
- Langerhans Cells
- Leptin
- Lipogenesis
- Liver
- Liver Cirrhosis
- Liver Cirrhosis, Biliary
- Liver Cirrhosis, Experimental
- Liver Diseases
- Liver Function Tests
- Liver Neoplasms
- Liver Neoplasms, Experimental
- Liver Regeneration
- Luciferases
- Macrophage Activation
- Male
- Mesenchymal Stromal Cells
- Mesoderm
- Metabolism
- Mice
- Mice, Inbred C57BL
- Mice, Inbred Strains
- Mice, Knockout
- Mice, Mutant Strains
- Mice, Obese
- Mice, Transgenic
- Middle Aged
- Mitochondria
- Molecular Sequence Data
- Myofibroblasts
- NADPH Oxidase
- Natural Killer T-Cells
- Neovascularization, Pathologic
- Nerve Regeneration
- Obesity
- Oligonucleotide Probes
- Osteopontin
- Oxidation-Reduction
- Oxidative Stress
- Paracrine Communication
- Platelet Count
- Platelet-Derived Growth Factor
- Polymerase Chain Reaction
- Prognosis
- Promoter Regions, Genetic
- Proto-Oncogene Proteins c-sis
- RNA, Messenger
- Rats
- Rats, Inbred F344
- Rats, Sprague-Dawley
- Rats, Zucker
- Reactive Oxygen Species
- Real-Time Polymerase Chain Reaction
- Receptors, Cell Surface
- Receptors, G-Protein-Coupled
- Receptors, Leptin
- Receptors, Notch
- Recurrence
- Regeneration
- Reverse Transcriptase Polymerase Chain Reaction
- Risk Factors
- Schistosoma mansoni
- Schistosomiasis mansoni
- Semliki forest virus
- Serotonin
- Signal Transduction
- Stem Cells
- T-Lymphocytes
- Transcriptome
- Transfection
- Transforming Growth Factor beta1
- Triglycerides
- Tumor Burden
- Tumor Necrosis Factor-alpha
- Tumor Necrosis Factors
- Up-Regulation
- Viral Proteins
- Virus Replication
- Wound Healing
- Young Adult
- rac GTP-Binding Proteins
- rac1 GTP-Binding Protein
- Research
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Selected Grants
- A systemically deliverable, RNAi-based approach for alcoholic liver disease awarded by Extend Biosciences 2014 - 2016
- Rac1 Promotes Hepatic Stellate Accumulation/Activation in Liver Injury awarded by National Institutes of Health 2009 - 2014
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Lee, Tzu-Hao, Austin Chan, William Bryan, Lawrence Park, Mohamed Hashem, Mary Townsend, Cynthia Moylan, Rachel Britt, Steve Choi, and Susanna Naggie. “Proton pump inhibitor usage reduces sustained viral response rates for veterans with HIV/HCV coinfection on ledipasvir/sofosbuvir: a real-world study from a multicentre VA cohort.” J Viral Hepat 28, no. 4 (April 2021): 630–36. https://doi.org/10.1111/jvh.13462.Full Text Link to Item
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Ronald, James, Erol Bozdogan, Islam H. Zaki, Matthew R. Kappus, Steven S. Choi, Jonathan G. Martin, Paul V. Suhocki, Tony P. Smith, Charles Y. Kim, and Mustafa R. Bashir. “Relative Sarcopenia With Excess Adiposity Predicts Survival After Transjugular Intrahepatic Portosystemic Shunt Creation.” Ajr Am J Roentgenol 214, no. 1 (January 2020): 200–205. https://doi.org/10.2214/AJR.19.21655.Full Text Link to Item
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“Unclear Statement.” Jama 322, no. 4 (July 23, 2019): 369. https://doi.org/10.1001/jama.2019.9668.Full Text Link to Item
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Ronald, James, Rajiv Rao, Steven S. Choi, Matthew Kappus, Jonathan G. Martin, Alan A. Sag, Waleska M. Pabon-Ramos, Paul V. Suhocki, Tony P. Smith, and Charles Y. Kim. “No Increased Mortality After TIPS Compared with Serial Large Volume Paracenteses in Patients with Higher Model for End-Stage Liver Disease Score and Refractory Ascites.” Cardiovasc Intervent Radiol 42, no. 5 (May 2019): 720–28. https://doi.org/10.1007/s00270-018-02155-9.Full Text Link to Item
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Wilder, Julius, Steve S. Choi, and Cynthia A. Moylan. “Evaluation for Fibrosis After Cure of Hepatitis C-Reply.” Jama 321, no. 15 (April 16, 2019): 1535. https://doi.org/10.1001/jama.2019.0873.Full Text Link to Item
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Lewis, Douglas S., Tzu-Hao Lee, Meghana Konanur, Cole Ziegler, Melissa D. Hall, Waleska M. Pabon-Ramos, Paul V. Suhocki, et al. “Proton Pump Inhibitor Use Is Associated with an Increased Frequency of New or Worsening Hepatic Encephalopathy after Transjugular Intrahepatic Portosystemic Shunt Creation.” J Vasc Interv Radiol 30, no. 2 (February 2019): 163–69. https://doi.org/10.1016/j.jvir.2018.10.015.Full Text Link to Item
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Wilder, Julius, Steve S. Choi, and Cynthia A. Moylan. “Vibration-Controlled Transient Elastography for Diagnosing Cirrhosis and Staging Hepatic Fibrosis.” Jama 320, no. 19 (November 20, 2018): 2031–32. https://doi.org/10.1001/jama.2018.13073.Full Text Link to Item
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Chino, Fumiko, Kimberly Ellen Pollis, Steve Choi, Joseph K. Salama, and Manisha Palta. “Stereotactic Body Radiation Therapy-Induced Abscopal Effect on Hepatocellular Carcinoma After Treatment for Lung Cancer: A Case Report.” Hepatology 68, no. 4 (October 2018): 1653–55. https://doi.org/10.1002/hep.30100.Full Text Link to Item
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Patel, Yuval A., Elizabeth J. Gifford, Lisa M. Glass, Marsha J. Turner, Byungjoo Han, Cynthia A. Moylan, Steve Choi, Ayako Suzuki, Dawn Provenzale, and Christine M. Hunt. “Correction to: Identifying Nonalcoholic Fatty Liver Disease Advanced Fibrosis in the Veterans Health Administration.” Dig Dis Sci 63, no. 10 (October 2018): 2813–14. https://doi.org/10.1007/s10620-018-5213-2.Full Text Open Access Copy Link to Item
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Chino, Fumiko, Sarah Jo Stephens, Steve S. Choi, Daniele Marin, Charles Y. Kim, Michael A. Morse, Devon J. Godfrey, Brian G. Czito, Christopher G. Willett, and Manisha Palta. “The role of external beam radiotherapy in the treatment of hepatocellular cancer.” Cancer 124, no. 17 (September 1, 2018): 3476–89. https://doi.org/10.1002/cncr.31334.Full Text Link to Item
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Patel, Yuval A., Elizabeth J. Gifford, Lisa M. Glass, Marsha J. Turner, Byungjoo Han, Cynthia A. Moylan, Steve Choi, Ayako Suzuki, Dawn Provenzale, and Christine M. Hunt. “Identifying Nonalcoholic Fatty Liver Disease Advanced Fibrosis in the Veterans Health Administration.” Dig Dis Sci 63, no. 9 (September 2018): 2259–66. https://doi.org/10.1007/s10620-018-5123-3.Full Text Link to Item
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Naggie, Susanna, Marzena Swiderska-Syn, Steve Choi, Sam Lusk, Audrey Lan, Guido Ferrari, Wing-Kin Syn, Cynthia D. Guy, and Anna Mae Diehl. “Markers of Tissue Repair and Cellular Aging Are Increased in the Liver Tissue of Patients With HIV Infection Regardless of Presence of HCV Coinfection.” Open Forum Infect Dis 5, no. 7 (July 2018): ofy138. https://doi.org/10.1093/ofid/ofy138.Full Text Open Access Copy Link to Item
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Ronald, J., Q. Wang, S. S. Choi, P. V. Suhocki, M. D. Hall, T. P. Smith, and C. Y. Kim. “Albumin-bilirubin grade versus MELD score for predicting survival after transjugular intrahepatic portosystemic shunt (TIPS) creation.” Diagn Interv Imaging 99, no. 3 (March 2018): 163–68. https://doi.org/10.1016/j.diii.2017.10.008.Full Text Link to Item
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Kasarala, George, Steve Choi, Katie Lopez, Rachel B. Britt, Colleen Boatright, and Hans L. Tillmann. “Curing hepatitis C virus (HCV) after organ transplantation: Increased risk of rejection following HCV elimination.” Transpl Infect Dis 20, no. 1 (February 2018). https://doi.org/10.1111/tid.12796.Full Text Link to Item
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Patel, Y. A., E. J. Gifford, L. M. Glass, R. McNeil, M. J. Turner, B. Han, D. Provenzale, S. S. Choi, C. A. Moylan, and C. M. Hunt. “Risk factors for biopsy-proven advanced non-alcoholic fatty liver disease in the Veterans Health Administration.” Aliment Pharmacol Ther 47, no. 2 (January 2018): 268–78. https://doi.org/10.1111/apt.14411.Full Text Link to Item
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Chan, Austin W., Yuval A. Patel, and Steve Choi. “Aging of the Liver: What This Means for Patients with HIV.” Curr Hiv/Aids Rep 13, no. 6 (December 2016): 309–17. https://doi.org/10.1007/s11904-016-0332-x.Full Text Link to Item
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Michelotti, Gregory A., Anikia Tucker, Marzena Swiderska-Syn, Mariana Verdelho Machado, Steve S. Choi, Leandi Kruger, Erik Soderblom, et al. “Pleiotrophin regulates the ductular reaction by controlling the migration of cells in liver progenitor niches.” Gut 65, no. 4 (April 2016): 683–92. https://doi.org/10.1136/gutjnl-2014-308176.Full Text Open Access Copy Link to Item
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Coombes, Jason D., Steve S. Choi, Marzena Swiderska-Syn, Paul Manka, Danielle T. Reid, Elena Palma, Marco A. Briones-Orta, et al. “Osteopontin is a proximal effector of leptin-mediated non-alcoholic steatohepatitis (NASH) fibrosis.” Biochim Biophys Acta 1862, no. 1 (January 2016): 135–44. https://doi.org/10.1016/j.bbadis.2015.10.028.Full Text Link to Item
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Michelotti, Gregory A., Anikia Tucker, Marzena Swiderska-Syn, Mariana Verdelho Machado, Steve S. Choi, Leandi Kruger, Erik Soderblom, et al. “Pleiotrophin regulates the ductular reaction by controlling the migration of cells in liver progenitor niches.” Gut 65, no. 4 (2016): 683–92. https://doi.org/10.1136/gutjnl-2014-308176.Full Text Link to Item
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Pereira, Thiago A., Wing-Kin Syn, Mariana V. Machado, Paula V. Vidigal, Vivian Resende, Izabela Voieta, Guanhua Xie, et al. “Schistosome-induced cholangiocyte proliferation and osteopontin secretion correlate with fibrosis and portal hypertension in human and murine schistosomiasis mansoni.” Clin Sci (Lond) 129, no. 10 (November 2015): 875–83. https://doi.org/10.1042/CS20150117.Full Text Open Access Copy Link to Item
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Uschner, Frank E., Ganesh Ranabhat, Steve S. Choi, Michaela Granzow, Sabine Klein, Robert Schierwagen, Esther Raskopf, et al. “Statins activate the canonical hedgehog-signaling and aggravate non-cirrhotic portal hypertension, but inhibit the non-canonical hedgehog signaling and cirrhotic portal hypertension.” Sci Rep 5 (September 28, 2015): 14573. https://doi.org/10.1038/srep14573.Full Text Link to Item
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Coombes, J. D., M. Swiderska-Syn, L. Dollé, D. Reid, B. Eksteen, L. Claridge, M. A. Briones-Orta, et al. “Osteopontin neutralisation abrogates the liver progenitor cell response and fibrogenesis in mice.” Gut 64, no. 7 (July 2015): 1120–31. https://doi.org/10.1136/gutjnl-2013-306484.Full Text Link to Item
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Karaca, Gamze, Guanhua Xie, Cynthia Moylan, Marzena Swiderska-Syn, Cynthia D. Guy, Leandi Krüger, Mariana Verdelho Machado, et al. “Role of Fn14 in acute alcoholic steatohepatitis in mice.” Am J Physiol Gastrointest Liver Physiol 308, no. 4 (February 15, 2015): G325–34. https://doi.org/10.1152/ajpgi.00429.2013.Full Text Link to Item
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Kim, Jieun, Sihyung Wang, Jeongeun Hyun, Steve S. Choi, Heejae Cha, Meesun Ock, and Youngmi Jung. “Hepatic stellate cells express thymosin Beta 4 in chronically damaged liver.” Plos One 10, no. 3 (2015): e0122758. https://doi.org/10.1371/journal.pone.0122758.Full Text Open Access Copy Link to Item
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Swiderska-Syn, M., W. K. Syn, G. Xie, L. Krüger, M. V. Machado, G. Karaca, G. A. Michelotti, S. S. Choi, R. T. Premont, and A. M. Diehl. “Myofibroblastic cells function as progenitors to regenerate murine livers after partial hepatectomy.” Gut 63, no. 8 (August 2014): 1333–44. https://doi.org/10.1136/gutjnl-2013-305962.Full Text Link to Item
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Choi, Steve S., Lee C. Claridge, Ravi Jhaveri, Marzena Swiderska-Syn, Paul Clark, Ayako Suzuki, Thiago A. Pereira, et al. “Osteopontin is up-regulated in chronic hepatitis C and is associated with cellular permissiveness for hepatitis C virus replication.” Clin Sci (Lond) 126, no. 12 (June 2014): 845–55. https://doi.org/10.1042/CS20130473.Full Text Link to Item
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Chan, Isaac S., Cynthia D. Guy, Mariana V. Machado, Abigail Wank, Vishnu Kadiyala, Gregory Michelotti, Steve Choi, et al. “Alcohol activates the hedgehog pathway and induces related procarcinogenic processes in the alcohol-preferring rat model of hepatocarcinogenesis.” Alcohol Clin Exp Res 38, no. 3 (March 2014): 787–800. https://doi.org/10.1111/acer.12279.Full Text Link to Item
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Hyun, Jeongeun, Steve S. Choi, Anna Mae Diehl, and Youngmi Jung. “Potential role of Hedgehog signaling and microRNA-29 in liver fibrosis of IKKβ-deficient mouse.” J Mol Histol 45, no. 1 (February 2014): 103–12. https://doi.org/10.1007/s10735-013-9532-5.Full Text Link to Item
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Moylan, Cynthia A., Herbert Pang, Andrew Dellinger, Ayako Suzuki, Melanie E. Garrett, Cynthia D. Guy, Susan K. Murphy, et al. “Hepatic gene expression profiles differentiate presymptomatic patients with mild versus severe nonalcoholic fatty liver disease.” Hepatology 59, no. 2 (February 2014): 471–82. https://doi.org/10.1002/hep.26661.Full Text Link to Item
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Karaca, Gamze, Marzena Swiderska-Syn, Guanhua Xie, Wing-Kin Syn, Leandi Krüger, Mariana Verdelho Machado, Katherine Garman, et al. “TWEAK/Fn14 signaling is required for liver regeneration after partial hepatectomy in mice.” Plos One 9, no. 1 (2014): e83987. https://doi.org/10.1371/journal.pone.0083987.Full Text Open Access Copy Link to Item
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Xie, Guanhua, Gamze Karaca, Marzena Swiderska-Syn, Gregory A. Michelotti, Leandi Krüger, Yuping Chen, Richard T. Premont, Steve S. Choi, and Anna Mae Diehl. “Cross-talk between Notch and Hedgehog regulates hepatic stellate cell fate in mice.” Hepatology 58, no. 5 (November 2013): 1801–13. https://doi.org/10.1002/hep.26511.Full Text Link to Item
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Michelotti, Gregory A., Guanhua Xie, Marzena Swiderska, Steve S. Choi, Gamze Karaca, Leandi Krüger, Richard Premont, et al. “Smoothened is a master regulator of adult liver repair.” J Clin Invest 123, no. 6 (June 2013): 2380–94. https://doi.org/10.1172/JCI66904.Full Text Link to Item
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Xie, Guanhua, Steve S. Choi, Wing-Kin Syn, Gregory A. Michelotti, Marzena Swiderska, Gamze Karaca, Isaac S. Chan, Yuping Chen, and Anna Mae Diehl. “Hedgehog signalling regulates liver sinusoidal endothelial cell capillarisation.” Gut 62, no. 2 (February 2013): 299–309. https://doi.org/10.1136/gutjnl-2011-301494.Full Text Link to Item
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Pereira, Thiago A., Guanhua Xie, Steve S. Choi, Wing-Kin Syn, Izabela Voieta, Jiuyi Lu, Isaac S. Chan, et al. “Macrophage-derived Hedgehog ligands promotes fibrogenic and angiogenic responses in human schistosomiasis mansoni.” Liver Int 33, no. 1 (January 2013): 149–61. https://doi.org/10.1111/liv.12016.Full Text Link to Item
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Chan, Isaac S., Cynthia D. Guy, Yuping Chen, Jiuyi Lu, Marzena Swiderska-Syn, Gregory A. Michelotti, Gamze Karaca, et al. “Paracrine Hedgehog signaling drives metabolic changes in hepatocellular carcinoma.” Cancer Res 72, no. 24 (December 15, 2012): 6344–50. https://doi.org/10.1158/0008-5472.CAN-12-1068.Full Text Link to Item
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Arzumanyan, Alla, Vaishnavi Sambandam, Marcia M. Clayton, Steve S. Choi, Guanhua Xie, Anna Mae Diehl, Dae-Yeul Yu, and Mark A. Feitelson. “Hedgehog signaling blockade delays hepatocarcinogenesis induced by hepatitis B virus X protein.” Cancer Res 72, no. 22 (November 15, 2012): 5912–20. https://doi.org/10.1158/0008-5472.CAN-12-2329.Full Text Link to Item
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Tillman, Hans L., and Steve S. Choi. “Risk for hepatocellular carcinoma in patients with alcoholic cirrhosis.” Ann Intern Med 157, no. 9 (November 6, 2012): 677–78. https://doi.org/10.7326/0003-4819-157-9-201211060-00022.Full Text Link to Item
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Chen, Yuping, Steve S. Choi, Gregory A. Michelotti, Isaac S. Chan, Marzena Swiderska-Syn, Gamze F. Karaca, Guanhua Xie, et al. “Hedgehog controls hepatic stellate cell fate by regulating metabolism.” Gastroenterology 143, no. 5 (November 2012): 1319-1329.e11. https://doi.org/10.1053/j.gastro.2012.07.115.Full Text Link to Item
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Syn, Wing-Kin, Kolade M. Agboola, Marzena Swiderska, Gregory A. Michelotti, Evaggelia Liaskou, Herbert Pang, Guanhua Xie, et al. “NKT-associated hedgehog and osteopontin drive fibrogenesis in non-alcoholic fatty liver disease.” Gut 61, no. 9 (September 2012): 1323–29. https://doi.org/10.1136/gutjnl-2011-301857.Full Text Link to Item
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Liaskou, E., H. Zimmermann, Z. Stamataki, O. Qureshi, S. S. Choi, J. Shaw, S. M. Curbishley, W. K. Syn, and D. H. Adams. “PMO-119 Phenotypically and functionally distinct monocyte subsets and their role in human liver disease.” Gut 61, no. Suppl 2 (July 2012): A121.1-A121. https://doi.org/10.1136/gutjnl-2012-302514b.119.Full Text
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Romac, Joelle M-J, Rafiq A. Shahid, Steve S. Choi, Gamze F. Karaca, Christoph B. Westphalen, Timothy C. Wang, and Rodger A. Liddle. “Pancreatic secretory trypsin inhibitor I reduces the severity of chronic pancreatitis in mice overexpressing interleukin-1β in the pancreas.” Am J Physiol Gastrointest Liver Physiol 302, no. 5 (March 1, 2012): G535–41. https://doi.org/10.1152/ajpgi.00287.2011.Full Text Link to Item
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Choi, Steve, and Anna Mae Diehl. “After goodbye? Dead hepatocytes as a biomarker for fibrosis and steatohepatitis.” Hepatology 55, no. 2 (February 2012): 333–35. https://doi.org/10.1002/hep.25540.Full Text Link to Item
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Choi, Steve S., Shelton Bradrick, Guan Qiang, Anahita Mostafavi, Gaurav Chaturvedi, Steven A. Weinman, Anna Mae Diehl, and Ravi Jhaveri. “Up-regulation of Hedgehog pathway is associated with cellular permissiveness for hepatitis C virus replication.” Hepatology 54, no. 5 (November 2011): 1580–90. https://doi.org/10.1002/hep.24576.Full Text Link to Item
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Omenetti, Alessia, Lee M. Bass, Robert A. Anders, Maria G. Clemente, Heather Francis, Cynthia D. Guy, Shannon McCall, et al. “Hedgehog activity, epithelial-mesenchymal transitions, and biliary dysmorphogenesis in biliary atresia.” Hepatology 53, no. 4 (April 2011): 1246–58. https://doi.org/10.1002/hep.24156.Full Text Link to Item
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Omenetti, Alessia, Liu Yang, Raul R. Gainetdinov, Cynthia D. Guy, Steve S. Choi, Wei Chen, Marc G. Caron, and Anna Mae Diehl. “Paracrine modulation of cholangiocyte serotonin synthesis orchestrates biliary remodeling in adults.” Am J Physiol Gastrointest Liver Physiol 300, no. 2 (February 2011): G303–15. https://doi.org/10.1152/ajpgi.00368.2010.Full Text Link to Item
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Choi, Steve S., Alessia Omenetti, Wing-Kin Syn, and Anna Mae Diehl. “The role of Hedgehog signaling in fibrogenic liver repair.” Int J Biochem Cell Biol 43, no. 2 (February 2011): 238–44. https://doi.org/10.1016/j.biocel.2010.10.015.Full Text Link to Item
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Omenetti, Alessia, Steve Choi, Gregory Michelotti, and Anna Mae Diehl. “Hedgehog signaling in the liver.” J Hepatol 54, no. 2 (February 2011): 366–73. https://doi.org/10.1016/j.jhep.2010.10.003.Full Text Link to Item
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Philips, George M., Isaac S. Chan, Marzena Swiderska, Vanessa T. Schroder, Cynthia Guy, Gamze F. Karaca, Cynthia Moylan, et al. “Hedgehog signaling antagonist promotes regression of both liver fibrosis and hepatocellular carcinoma in a murine model of primary liver cancer.” Plos One 6, no. 9 (2011): e23943. https://doi.org/10.1371/journal.pone.0023943.Full Text Open Access Copy Link to Item
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Syn, Wing-Kin, Steve S. Choi, Evaggelia Liaskou, Gamze F. Karaca, Kolade M. Agboola, Ye Htun Oo, Zhiyong Mi, et al. “Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis.” Hepatology 53, no. 1 (January 2011): 106–15. https://doi.org/10.1002/hep.23998.Full Text Link to Item
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Pereira, Thiago de Almeida, Rafal P. Witek, Wing-Kin Syn, Steve S. Choi, Shelton Bradrick, Gamze F. Karaca, Kolade M. Agboola, et al. “Viral factors induce Hedgehog pathway activation in humans with viral hepatitis, cirrhosis, and hepatocellular carcinoma.” Lab Invest 90, no. 12 (December 2010): 1690–1703. https://doi.org/10.1038/labinvest.2010.147.Full Text Open Access Copy Link to Item
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Choi, Steve S., Wing-Kin Syn, Gamze F. Karaca, Alessia Omenetti, Cynthia A. Moylan, Rafal P. Witek, Kolade M. Agboola, Youngmi Jung, Gregory A. Michelotti, and Anna Mae Diehl. “Leptin promotes the myofibroblastic phenotype in hepatic stellate cells by activating the hedgehog pathway.” J Biol Chem 285, no. 47 (November 19, 2010): 36551–60. https://doi.org/10.1074/jbc.M110.168542.Full Text Link to Item
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Choi, Steve S., Rafal P. Witek, Liu Yang, Alessia Omenetti, Wing-Kin Syn, Cynthia A. Moylan, Youngmi Jung, et al. “Activation of Rac1 promotes hedgehog-mediated acquisition of the myofibroblastic phenotype in rat and human hepatic stellate cells.” Hepatology 52, no. 1 (July 2010): 278–90. https://doi.org/10.1002/hep.23649.Full Text Link to Item
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Syn, Wing-Kin, Ye Htun Oo, Thiago A. Pereira, Gamze F. Karaca, Youngmi Jung, Alessia Omenetti, Rafal P. Witek, et al. “Accumulation of natural killer T cells in progressive nonalcoholic fatty liver disease.” Hepatology 51, no. 6 (June 2010): 1998–2007. https://doi.org/10.1002/hep.23599.Full Text Link to Item
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Jung, Youngmi, Rafal P. Witek, Wing-Kin Syn, Steve S. Choi, Alessia Omenetti, Richard Premont, Cynthia D. Guy, and Anna Mae Diehl. “Signals from dying hepatocytes trigger growth of liver progenitors.” Gut 59, no. 5 (May 2010): 655–65. https://doi.org/10.1136/gut.2009.204354.Full Text Link to Item
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Ochoa, Begoña, Wing-Kin Syn, Igotz Delgado, Gamze F. Karaca, Youngmi Jung, Jiangbo Wang, Ana M. Zubiaga, et al. “Hedgehog signaling is critical for normal liver regeneration after partial hepatectomy in mice.” Hepatology 51, no. 5 (May 2010): 1712–23. https://doi.org/10.1002/hep.23525.Full Text Link to Item
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McGoogan, Katherine E., P Brian Smith, Steve S. Choi, Wallace Berman, and Ravi Jhaveri. “Performance of the AST-to-platelet ratio index as a noninvasive marker of fibrosis in pediatric patients with chronic viral hepatitis.” J Pediatr Gastroenterol Nutr 50, no. 3 (March 2010): 344–46. https://doi.org/10.1097/MPG.0b013e3181aed725.Full Text Link to Item
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Choi, Steve S., Alessia Omenetti, Rafal P. Witek, Cynthia A. Moylan, Wing-Kin Syn, Youngmi Jung, Liu Yang, et al. “Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis.” Am J Physiol Gastrointest Liver Physiol 297, no. 6 (December 2009): G1093–1106. https://doi.org/10.1152/ajpgi.00292.2009.Full Text Link to Item
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Choi, Steve S., and Anna Mae Diehl. “Epithelial-to-mesenchymal transitions in the liver.” Hepatology 50, no. 6 (December 2009): 2007–13. https://doi.org/10.1002/hep.23196.Full Text Link to Item
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Syn, Wing-Kin, Steve S. Choi, and Anna Mae Diehl. “Apoptosis and cytokines in non-alcoholic steatohepatitis.” Clin Liver Dis 13, no. 4 (November 2009): 565–80. https://doi.org/10.1016/j.cld.2009.07.003.Full Text Link to Item
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Witek, Rafal P., W Carl Stone, F Gamze Karaca, Wing-Kin Syn, Thiago A. Pereira, Kolade M. Agboola, Alessia Omenetti, et al. “Pan-caspase inhibitor VX-166 reduces fibrosis in an animal model of nonalcoholic steatohepatitis.” Hepatology 50, no. 5 (November 2009): 1421–30. https://doi.org/10.1002/hep.23167.Full Text Link to Item
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Syn, Wing-Kin, Youngmi Jung, Alessia Omenetti, Manal Abdelmalek, Cynthia D. Guy, Liu Yang, Jiangbo Wang, et al. “Hedgehog-mediated epithelial-to-mesenchymal transition and fibrogenic repair in nonalcoholic fatty liver disease.” Gastroenterology 137, no. 4 (October 2009): 1478-1488.e8. https://doi.org/10.1053/j.gastro.2009.06.051.Full Text Link to Item
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Syn, Wing-Kin, Liu Yang, Dian Jung Chiang, Yue Qian, Youngmi Jung, Gamze Karaca, Steve S. Choi, et al. “Genetic differences in oxidative stress and inflammatory responses to diet-induced obesity do not alter liver fibrosis in mice.” Liver Int 29, no. 8 (September 2009): 1262–72. https://doi.org/10.1111/j.1478-3231.2009.02036.x.Full Text Link to Item
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Omenetti, Alessia, Wing-Kin Syn, Youngmi Jung, Heather Francis, Alessandro Porrello, Rafal P. Witek, Steve S. Choi, et al. “Repair-related activation of hedgehog signaling promotes cholangiocyte chemokine production.” Hepatology 50, no. 2 (August 2009): 518–27. https://doi.org/10.1002/hep.23019.Full Text Link to Item
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Syn, Wing-Kin, Rafal P. Witek, Stuart M. Curbishley, Youngmi Jung, Steve S. Choi, Barbara Enrich, Alessia Omenetti, et al. “Role for hedgehog pathway in regulating growth and function of invariant NKT cells.” Eur J Immunol 39, no. 7 (July 2009): 1879–92. https://doi.org/10.1002/eji.200838890.Full Text Link to Item
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Syn, Wing-Kin, Vanessa Teaberry, Steve S. Choi, and Anna Mae Diehl. “Similarities and differences in the pathogenesis of alcoholic and nonalcoholic steatohepatitis.” Semin Liver Dis 29, no. 2 (May 2009): 200–210. https://doi.org/10.1055/s-0029-1214375.Full Text Link to Item
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Omenetti, A., W. -. K. Syn, Y. Jung, R. P. Witek, S. S. Choi, and A. M. Diehl. “75 MYOFIBROBLASTS PROVIDE HEDGEHOG PARACRINE SIGNALS THAT DRIVE CHOLANGIOCYTES TO RECRUIT NKT CELLS TO PORTAL TRACTS.” Journal of Hepatology 50 (April 2009): S31–32. https://doi.org/10.1016/s0168-8278(09)60077-5.Full Text
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Miller, Meredith W., Sandeep Basra, Daniel W. Kulp, Paul C. Billings, Sungwook Choi, Mary Pat Beavers, Owen J. T. McCarty, et al. “Small-molecule inhibitors of integrin alpha2beta1 that prevent pathological thrombus formation via an allosteric mechanism.” Proc Natl Acad Sci U S A 106, no. 3 (January 20, 2009): 719–24. https://doi.org/10.1073/pnas.0811622106.Full Text Link to Item
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Witek, Rafal P., Liu Yang, Renshui Liu, Youngmi Jung, Alessia Omenetti, Wing-Kin Syn, Steve S. Choi, et al. “Liver cell-derived microparticles activate hedgehog signaling and alter gene expression in hepatic endothelial cells.” Gastroenterology 136, no. 1 (January 2009): 320-330.e2. https://doi.org/10.1053/j.gastro.2008.09.066.Full Text Link to Item
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Jou, Janice, Steve S. Choi, and Anna Mae Diehl. “Mechanisms of disease progression in nonalcoholic fatty liver disease.” Semin Liver Dis 28, no. 4 (November 2008): 370–79. https://doi.org/10.1055/s-0028-1091981.Full Text Link to Item
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Omenetti, Alessia, Alessandro Porrello, Youngmi Jung, Liu Yang, Yury Popov, Steve S. Choi, Rafal P. Witek, et al. “Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans.” J Clin Invest 118, no. 10 (October 2008): 3331–42. https://doi.org/10.1172/JCI35875.Full Text Link to Item
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Omenetti, A., Y. Popov, Y. Jung, S. S. Choi, R. P. Witek, L. Yang, K. D. Brown, D. Schuppan, and A. M. Diehl. “The hedgehog pathway regulates remodelling responses to biliary obstruction in rats.” Gut 57, no. 9 (September 2008): 1275–82. https://doi.org/10.1136/gut.2008.148619.Full Text Link to Item
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Yang, Liu, Youngmi Jung, Alessia Omenetti, Rafal P. Witek, Steve Choi, Hendrika M. Vandongen, Jiawen Huang, Gianfranco D. Alpini, and Anna Mae Diehl. “Fate-mapping evidence that hepatic stellate cells are epithelial progenitors in adult mouse livers.” Stem Cells 26, no. 8 (August 2008): 2104–13. https://doi.org/10.1634/stemcells.2008-0115.Full Text Link to Item
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Choi, Steve S., and Anna Mae Diehl. “Hepatic triglyceride synthesis and nonalcoholic fatty liver disease.” Curr Opin Lipidol 19, no. 3 (June 2008): 295–300. https://doi.org/10.1097/MOL.0b013e3282ff5e55.Full Text Link to Item
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Fleig, Susanne V., Steve S. Choi, Liu Yang, Youngmi Jung, Alessia Omenetti, Hendrika M. VanDongen, Jiawen Huang, Jason K. Sicklick, and Anna Mae Diehl. “Hepatic accumulation of Hedgehog-reactive progenitors increases with severity of fatty liver damage in mice.” Lab Invest 87, no. 12 (December 2007): 1227–39. https://doi.org/10.1038/labinvest.3700689.Full Text Link to Item
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Omenetti, Alessia, Liu Yang, Yin-Xiong Li, Shannon J. McCall, Youngmi Jung, Jason K. Sicklick, Jiawen Huang, Steve Choi, Ayako Suzuki, and Anna Mae Diehl. “Hedgehog-mediated mesenchymal-epithelial interactions modulate hepatic response to bile duct ligation.” Lab Invest 87, no. 5 (May 2007): 499–514. https://doi.org/10.1038/labinvest.3700537.Full Text Link to Item
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Choi, Steve S., Jason K. Sicklick, Qi Ma, Liu Yang, Jiawen Huang, Yi Qi, Wei Chen, Yin-Xiong Li, Pascal J. Goldschmidt-Clermont, and Anna Mae Diehl. “Sustained activation of Rac1 in hepatic stellate cells promotes liver injury and fibrosis in mice.” Hepatology 44, no. 5 (November 2006): 1267–77. https://doi.org/10.1002/hep.21375.Full Text Link to Item
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Sicklick, Jason K., Steve S. Choi, Marcia Bustamante, Shannon J. McCall, Elizabeth Hernández Pérez, Jiawen Huang, Yin-Xiong Li, Marcos Rojkind, and Anna Mae Diehl. “Evidence for epithelial-mesenchymal transitions in adult liver cells.” Am J Physiol Gastrointest Liver Physiol 291, no. 4 (October 2006): G575–83. https://doi.org/10.1152/ajpgi.00102.2006.Full Text Link to Item
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Suzuki, Ayako, Shannon McCall, Steve S. Choi, Jason K. Sicklick, Jiawen Huang, Yi Qi, Marzena Zdanowicz, Terese Camp, Yin-Xiong Li, and Anna Mae Diehl. “Interleukin-15 increases hepatic regenerative activity.” J Hepatol 45, no. 3 (September 2006): 410–18. https://doi.org/10.1016/j.jhep.2006.04.008.Full Text Link to Item
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Choi, Steve, and Anna Mae Diehl. “Role of inflammation in nonalcoholic steatohepatitis.” Curr Opin Gastroenterol 21, no. 6 (November 2005): 702–7. https://doi.org/10.1097/01.mog.0000182863.96421.47.Full Text Link to Item
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Sicklick, Jason K., Yin-Xiong Li, Steve S. Choi, Yi Qi, Wei Chen, Marcia Bustamante, Jiawen Huang, et al. “Role for hedgehog signaling in hepatic stellate cell activation and viability.” Lab Invest 85, no. 11 (November 2005): 1368–80. https://doi.org/10.1038/labinvest.3700349.Full Text Link to Item
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Hsieh, S. T., S. Choi, W. M. Lin, Y. C. Chang, J. C. Mcarthur, and J. W. Griffin. “Epidermal denervation and its effects on keratinocytes and Langerhans cells.” J Neurocytol 25, no. 9 (September 1996): 513–24. https://doi.org/10.1007/BF02284819.Full Text Link to Item
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Tucker, P. C., D. E. Griffin, S. Choi, N. Bui, and S. Wesselingh. “Inhibition of nitric oxide synthesis increases mortality in Sindbis virus encephalitis.” J Virol 70, no. 6 (June 1996): 3972–77. https://doi.org/10.1128/JVI.70.6.3972-3977.1996.Full Text Link to Item
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Mokhtarian, F., S. L. Wesselingh, S. Choi, A. Maeda, D. E. Griffin, R. A. Sobel, and D. Grob. “Production and role of cytokines in the CNS of mice with acute viral encephalomyelitis.” J Neuroimmunol 66, no. 1–2 (May 1996): 11–22. https://doi.org/10.1016/0165-5728(95)00181-6.Full Text Link to Item
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Rho, M. B., S. Wesselingh, J. D. Glass, J. C. McArthur, S. Choi, J. Griffin, and W. R. Tyor. “A potential role for interferon-alpha in the pathogenesis of HIV-associated dementia.” Brain Behav Immun 9, no. 4 (December 1995): 366–77. https://doi.org/10.1006/brbi.1995.1034.Full Text Link to Item
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Herskowitz, A., S. Choi, A. A. Ansari, and S. Wesselingh. “Cytokine mRNA expression in postischemic/reperfused myocardium.” Am J Pathol 146, no. 2 (February 1995): 419–28.Link to Item
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Bö, L., T. M. Dawson, S. Wesselingh, S. Mörk, S. Choi, P. A. Kong, D. Hanley, and B. D. Trapp. “Induction of nitric oxide synthase in demyelinating regions of multiple sclerosis brains.” Ann Neurol 36, no. 5 (November 1994): 778–86. https://doi.org/10.1002/ana.410360515.Full Text Link to Item
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Wesselingh, S. L., B. Levine, R. J. Fox, S. Choi, and D. E. Griffin. “Intracerebral cytokine mRNA expression during fatal and nonfatal alphavirus encephalitis suggests a predominant type 2 T cell response.” J Immunol 152, no. 3 (February 1, 1994): 1289–97.Link to Item
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Book Sections
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Choi, S. S., and A. M. Diehl. “Alcoholic liver disease.” In Handbook of Liver Disease, 109–20, 2018. https://doi.org/10.1016/B978-0-323-47874-8.00008-0.Full Text
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Choi, Steve S., and Anna Mae Diehl. “Hedgehog Signaling and Liver Regeneration.” In LIVER REGENERATION, 111–27, 2011.Link to Item
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Diehl, Anna Mae, and Steve S. Choi. “The Liver in Type 2 Diabetes Mellitus.” In Type 2 Diabetes Mellitus, 351–64. Humana Press, n.d. https://doi.org/10.1007/978-1-60327-043-4_21.Full Text
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Conference Papers
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Lee, Tzu-Hao, Austin Chan, William E. Bryan, Lawrence Park, Mohamed Hashem, Mary Townsend, Cynthia A. Moylan, Rachel B. Britt, Steve S. Choi, and Susanna Naggie. “USAGE OF PPI REDUCES THE SVR RATE FOR HIV-HCV COINFECTED PATIENTS USING LEDIPASVIR/SOFOSBUVIR: A REAL-WORLD STUDY FROM MULTICENTER VA COHORT.” In Gastroenterology, 156:S1345–S1345. W B SAUNDERS CO-ELSEVIER INC, 2019.Link to Item
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Shantzer, Lindsey, Stephanie Garbarino, and Steve S. Choi. “Metastatic Hepatocellular Carcinoma Secreting Intact PTH: A Case Report.” In American Journal of Gastroenterology, 113:S1331–32. NATURE PUBLISHING GROUP, 2018.Link to Item
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Du, Kuo, Jeongeun Hyun, Richard T. Premont, Steve S. Choi, Gregory A. Michelotti, Marzena Swiderska-Syn, George D. Dalton, et al. “Hedgehog-YAP Signaling Pathway Regulates Glutaminolysis to Control Activation of Hepatic Stellate Cells.” In Gastroenterology, 154:1465-1479.e13, 2018. https://doi.org/10.1053/j.gastro.2017.12.022.Full Text Link to Item
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Patel, Yuval A., Elizabeth Gifford, Lisa M. Glass, Rebecca McNeil, Marsha J. Turner, Byungjoo Han, Dawn T. Provenzale, Steve S. Choi, Cynthia A. Moylan, and Christine M. Hunt. “Diet/exercise programs are used by only one in five severely obese patients with biopsy-defined Nonalcoholic Fatty Liver Disease (NAFLD) advanced fibrosis in the Veterans Health Administration (VHA).” In Hepatology, 66:1164A-1164A. WILEY, 2017.Link to Item
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Chan, Austin W., William E. Bryan, Mohamed A. Hashem, Mary L. Townsend, Laura Ann Wang, Steve S. Choi, and Susanna Naggie. “Hepatitis C (HCV) Virologic Outcomes in Veterans taking Ledipasvir/Sofosbuvir with Concomitant Acid Suppressing Medication.” In Hepatology, 64:468A-468A. WILEY, 2016.Link to Item
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Rabatin, Abigail, Mohamed Hashem, Mary L. Townsend, William E. Bryan, Cynthia A. Moylan, Steve S. Choi, and Susanna Naggie. “Treatment Outcomes of Veterans with Decompensated Cirrhosis Receiving All Oral Direct Acting Antiviral Hepatitis C Therapy.” In Hepatology, 62:773A-773A. WILEY-BLACKWELL, 2015.Link to Item
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Uschner, Frank E., Ganesh Ranabhat, Michaela Granzow, Steve S. Choi, Sabine Klein, Robert Schierwagen, Esther Raskopf, et al. “Statins activate the canonical hedgehog-signaling and aggravate non-cirrhotic portal hypertension, but inhibit the non-canonical hedgehog signaling and cirrhotic portal hypertension.” In Hepatology, 62:249A-249A. WILEY-BLACKWELL, 2015.Link to Item
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Swiderska-Syn, M., S. Choi, A. Lan, G. Ferrari, A. M. Diehl, and S. Naggie. “P0469 : Markers of tissue repair and cellular aging are increased in liver tissue of patients with dual chronic HIV/HCV infections.” In Journal of Hepatology, 62:S489–S489. Elsevier BV, 2015. https://doi.org/10.1016/s0168-8278(15)30677-2.Full Text
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Naqvi, Ibtehaj A., Rebekah R. White, Cynthia A. Moylan, Anna Mae Diehl, and Steve S. Choi. “Abstract 4117: Utilizing RNA aptamers for biomarker discovery in a novel cell culture system for hepatocellular carcinoma.” In Cancer Research, 74:4117–4117. American Association for Cancer Research (AACR), 2014. https://doi.org/10.1158/1538-7445.am2014-4117.Full Text
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Coombes, J. D., M. Swiderska-Syn, L. Dollé, D. T. Reid, B. Eksteen, L. C. Claridge, M. A. Briones-Orta, et al. “P612 OSTEOPONTIN NEUTRALIZATION ABROGATES THE LIVER PROGENITOR CELL RESPONSE AND FIBROGENIC OUTCOMES IN MICE.” In Journal of Hepatology, 60:S273–S273. Elsevier BV, 2014. https://doi.org/10.1016/s0168-8278(14)60774-1.Full Text
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Coombes, Jason D., Steve S. Choi, Paul P. Manka, Marco A. Briones-Orta, Marzena Swiderska-Syn, Naoto Kitamura, Rasha Younis, et al. “Osteopontin mediates fibrogenic effects of leptin and enhances NASH progression.” In Hepatology, 60:748A-749A. WILEY-BLACKWELL, 2014.Link to Item
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Uschner, Frank E., Ganesh Ranabhat, Michaela Granzow, Steve S. Choi, Sabine Klein, Robert Schierwagen, Esther Raskopf, et al. “Hedgehog-signaling and angiogenesis in cirrhotic and non-cirrhotic portal hypertension.” In Hepatology, 60:1178A-1178A. WILEY-BLACKWELL, 2014.Link to Item
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Karaca, Gamze, Guanhua Xie, Marzena Swiderska-Syn, Gregory A. Michelotti, Steve S. Choi, Linda C. Burkly, and Anna Mae Diehl. “Absence of FN14 Ameliorates Acute Ethanol-Induced Steatohepatitis.” In Hepatology, 58:831A-831A. WILEY-BLACKWELL, 2013.Link to Item
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Pereira, Thiago A., Wing-Kin Syn, Steve S. Choi, Izabela Voieta, Vivian Resende, Marcia M. Souza, William E. Secor, et al. “Cholangiocyte proliferation and Osteopontin secretion is induced by Schistosoma mansoni egg antigens and correlates with fibrosis and portal hypertension in human and murine schistosomiasis.” In Hepatology, 58:847A-847A. WILEY-BLACKWELL, 2013.Link to Item
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Tucker, Anikia, Gregory A. Michelotti, Steve S. Choi, Guanhua Xie, Gamze Karaca, Marzena Swiderska-Syn, Leandi Kruger, Mariana V. Machado, Katherine S. Garman, and Anna Mae Diehl. “The Role of Pleiotrophin Signaling in the Hepatic Stem Cell Niche.” In Hepatology, 58:1007A-1007A. WILEY-BLACKWELL, 2013.Link to Item
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Xie, Guanhua, Gamze Karaca, Marzena Swiderska, Gregory A. Michelotti, Leandi Krueger, Steve S. Choi, and Anna Mae Diehl. “Notch Signaling Regulates Hepatic Stellate Cell Fate by Cross-Talking With Hedgehog Signaling.” In Gastroenterology, 144:S995–S995, 2013.Link to Item
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Choi, Steve S., Ravi Jhaveri, Shelton Bradrick, Paul C. Kuo, and Wing-Kin Syn. “Osteopontin regulates viral permissivity and replication in Huh7.5 cells infected with Hepatitis C Virus.” In Hepatology, 56:697A-697A. WILEY-BLACKWELL, 2012.Link to Item
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Liaskou, E., H. Zimmermann, S. S. Choi, O. Qureshi, Z. Stamataki, J. Shaw, S. M. Curbishley, W. -. K. Syn, and D. H. Adams. “379 THREE PHENOTYPICALLY AND FUNCTIONALLY DISTINCT MONOCYTE SUBSETS AND THEIR ROLE IN HUMAN LIVER FIBROSIS.” In Journal of Hepatology, 56:S153–S153. Elsevier BV, 2012. https://doi.org/10.1016/s0168-8278(12)60392-4.Full Text
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Chan, Isaac S., Marzena Swiderska, Cynthia D. Guy, Yuping Chen, Gamze Karaca, Guanhua Xie, Steve S. Choi, Gregory A. Michelotti, and Anna Mae Diehl. “Hedgehog Inhibition Regulates the Stromal Microenvironment in Hepatocellular Carcinoma via Suppression of the Warburg Effect.” In Gastroenterology, 142:S972–S972, 2012.Link to Item
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Choi, Steve S., Wing-Kin Syn, Marzena Swiderska, Michael P. Smith, Anna Mae Diehl, and Gregory A. Michelotti. “Nr4a1 Nuclear Orphan Receptor is a Novel Regulator of Hepatic Fibrosis.” In Gastroenterology, 142:S910–S910, 2012.Link to Item
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Liaskou, E., S. S. Choi, O. Qureshi, S. M. Curbishley, Z. Stamataki, W. -. K. Syn, and D. H. Adams. “CD14++CD16+monocyte/macrophages can induce fibrosis in human liver.” In Immunology, 135:89–89. WILEY-BLACKWELL, 2011.Link to Item
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Chan, Isaac S., George M. Philips, Marzena Zdanowicz, Vanessa Teaberry, Gamze Karaca, Fatima Rangwala, Cynthia D. Guy, et al. “HEDGEHOG PATHWAY INHIBITION BY GDC-0449 CAUSES REGRESSION OF HEPATOCELLULAR CARCINOMAS AND IMPROVES LIVER FIBROSIS IN MDR2-DEFICIENT MICE.” In Hepatology, 54:1278A-1278A. WILEY-BLACKWELL, 2011.Link to Item
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Chen, Yuping, Steve S. Choi, Gregory A. Michelotti, Cynthia A. Moylan, Gamze Karaca, Marzena Zdanowicz, Guanhua Xie, Leandi Kruger, and Anna Mae Diehl. “TRANSITION OF QUIESCENT STELLATE CELLS INTO MYOFIBROBLASTS REQUIRES HEDGEHOG-MEDIATED INDUCTION OF GLYCOLYSIS.” In Hepatology, 54:422A-422A. WILEY-BLACKWELL, 2011.Link to Item
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Michelotti, Gregory A., Steve S. Choi, Marzena Zdanowicz, Gamze Karaca, Richard T. Premont, and Anna Mae Diehl. “ABROGATION OF CANONICAL HEDGEHOG ACTIVITY DECREASES HEPATIC FIBROSIS.” In Hepatology, 54:434A-435A. WILEY-BLACKWELL, 2011.Link to Item
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Philips, George M., Isaac S. Chan, Steve S. Choi, Guanhua Xie, Gregory A. Michelotti, Marzena Zdanowicz, Vanessa Teaberry, et al. “HEDGEHOG PATHWAY INHIBITION INDUCES HCC TUMOR NECROSIS BY REPRESSING EXPRESSION OF ANGIOPOIETIN-2 AND ITS COGNATE RECEPTOR, TIE-2.” In Hepatology, 54:1280A-1280A. WILEY-BLACKWELL, 2011.Link to Item
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Philips, George M., Marzena Zdanowicz, Gregory A. Michelotti, Steve S. Choi, Gamze Karaca, Isaac S. Chan, and Anna Mae Diehl. “HEDGEHOG PATHWAY ACTIVATION OCCURS IN PULMONARY MICROVASCULATURE DURING EXPERIMENTAL HEPATOPULMONARY SYNDROME (HPS).” In Hepatology, 54:1235A-1235A. WILEY-BLACKWELL, 2011.Link to Item
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Xie, Guanhua, Steve S. Choi, Wing-Kin Syn, Gregory A. Michelotti, Marzena Zdanowicz, Gamze Karaca, Yuping Chen, and Anna Mae Diehl. “AUTOCRINE ACTIVATION OF THE HEDGEHOG PATHWAY DURING LIVER SINUSOIDAL ENDOTHELIAL CELL CAPILLARIZATION.” In Hepatology, 54:757A-757A. WILEY-BLACKWELL, 2011.Link to Item
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Moylan, Cynthia A., Andrew Dellinger, Herbert Pang, Ayako Suzuki, Hans L. Tillmann, Daniel Hampton, Yuping Chen, et al. “Modest Alcohol Consumption Attenuates Expression of Fibrosis-Associated Genes in Patients With Non-Alcoholic Fatty Liver Disease (NAFLD).” In Gastroenterology, 140:S914–15. W B SAUNDERS CO-ELSEVIER INC, 2011.Link to Item
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Choi, Steve S., Thiago A. Pereira, Wing-Kin Syn, Kolade M. Agboola, Cynthia A. Moylan, Alessia Omenetti, Gamze F. Karaca, Fatima Rangwala, Ravi Jhaveri, and Anna Mae Diehl. “CO-CULTURE OF LIVER EPITHELIAL CELLS STABLY TRANSFECTED WITH HEPATITIS B VIRUS X PROTEIN PROMOTES MYOFIBROBLASTIC ACTIVATION AND ACCUMULATION VIA A HEDGEHOG-MEDIATED PROCESS IN RAT HEPATIC STELLATE CELLS.” In Hepatology, 52:977A-978A. WILEY-BLACKWELL, 2010.Link to Item
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Choi, Steve S., Wing-Kin Syn, Michael P. Smith, Anna Mae Diehl, and Gregory A. Michelotti. “NR4A NUCLEAR ORPHAN RECEPTORS ARE NOVEL REGULATORS OF HEPATIC FIBROSIS.” In Hepatology, 52:606A-607A. WILEY-BLACKWELL, 2010.Link to Item
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Karaca, Gamze F., Yuping Chen, Wing-Kin Syn, Begona Ochoa, Steve S. Choi, Aniela Jakubowski, and Anna Mae Diehl. “DEFECTIVE LIVER REGENERATION AFTER PARTIAL HEPATECTOMY IN MICE LACKING FIBROBLAST GROWTH FACTOR INDUCIBLE 14.” In Hepatology, 52:969A-970A. WILEY-BLACKWELL, 2010.Link to Item
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Moylan, Cynthia A., Manal F. Abdelmalek, Herbert Pang, Andrew Dellinger, Steve S. Choi, Alessia Omenetti, Yuping Chen, et al. “SIGNALS FROM THE FIBROTIC LIVER IN PATIENTS WITH NAFLD MAY PROMOTE DIABETES AND OBESITY.” In Hepatology, 52:1049A-1050A. WILEY-BLACKWELL, 2010.Link to Item
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Moylan, Cynthia A., Steve S. Choi, Andrew Dellinger, Herbert Pang, Manal F. Abdelmalek, Daniel Hampton, Yuping Chen, et al. “CONSERVED GENE EXPRESSION PATTERNS IN MYOFIBROBLASTIC MURINE AND HUMAN HEPATIC STELLATE CELLS AND NAFLD PATIENTS WITH LIVER FIBROSIS COMPATIBLE WITH EPITHELIAL-TO-MESENCHYMAL LIKE TRANSITION.” In Hepatology, 52:1286A-1287A. WILEY-BLACKWELL, 2010.Link to Item
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Omenetti, Alessia, Lee M. Bass, Robert A. Anders, Maria Grazia Clemente, Heather Francis, Cynthia D. Guy, Steve S. Choi, et al. “HEDGEHOG PATHWAY DRIVES THE ACQUISITION OF MESENCHYMAL MARKERS IN DUCTULAR CELLS OF PATIENTS WITH BILIARY ATRESIA.” In Hepatology, 52:1022A-1023A. WILEY-BLACKWELL, 2010.Link to Item
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Omenetti, Alessia, Liu Yang, Raul R. Gainetdinov, Cynthia D. Guy, Steve S. Choi, Wei Chen, Marc G. Caron, and Anna Mae Diehl. “MYOFIBROBLAST-DERIVED TGF beta PROMOTES BILIARY TREE GROWTH DURING CHOLESTATIC LIVER INJURY BY SUPPRESSING ANGIOPOIETIN 1/TIE2/TRYPTOPHAN HYDROXYLASE 2 AXIS AND SEROTONIN SECRETION IN NEIGHBORING CHOLANGIOCYTES.” In Hepatology, 52:407A-408A. WILEY-BLACKWELL, 2010.Link to Item
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Pereira, Thiago A., Wing-Kin Syn, Izabela Voieta, Lu Jiuyi, Steve S. Choi, Rafal P. Witek, Kolade M. Agboola, et al. “MACROPHAGE-DERIVED HEDGEHOG LIGANDS PROMOTES FIBROGENIC RESPONSES IN SCHISTOSOMIASIS MANSONI.” In Hepatology, 52:611A-612A. WILEY-BLACKWELL, 2010.Link to Item
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Syn, Wing-Kin, Steve S. Choi, Evaggelia Liaskou, Gamze F. Karaca, Ye H. Oo, Thiago A. Pereira, Syamal D. Bhattacharya, et al. “OSTEOPONTIN PROMOTES NONALCOHOLIC FATTY LIVER DISEASE PROGRESSION.” In Hepatology, 52:350A-351A. WILEY-BLACKWELL, 2010.Link to Item
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Moylan, Cynthia A., Steve S. Choi, Chaitanya R. Acharya, Wing-Kin Syn, Alessia Omenetti, Youngmi Jung, Debra L. Sudan, Andrew J. Muir, Anil Potti, and Anna Mae Diehl. “Gene Expression Profiles During Activation of Human Hepatic Stellate Cells Suggest an Epithelial-to-Mesenchymal Transition-Like Process.” In Gastroenterology, 138:S838–S838. W B SAUNDERS CO-ELSEVIER INC, 2010.Link to Item
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Choi, Steve S., Wing-Kin Syn, Gamze F. Karaca, Alessia Omenetti, Xiaoling Wang, Youngmi Jung, Vanessa S. Teaberry, Cynthia A. Moylan, and Anna Mae Diehl. “Leptin Activates Hedgehog Pathway Signaling and Promotes Myofibroblastic Transition and Accumulation in Rat Hepatic Stellate Cells.” In Gastroenterology, 138:S837–S837, 2010.Link to Item
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Choi, Steve S., Rafal P. Witek, Wing-Kin Syn, Alessia Omenetti, Gamze F. Karaca, Youngmi Jung, Vanessa S. Teaberry, and Anna Mae Diehl. “INTERACTION BETWEEN HEDGEHOG PATHWAY SIGNALING AND LEPTIN IN RAT HEPATIC STELLATE CELLS.” In Hepatology, 50:828A-828A. JOHN WILEY & SONS INC, 2009.Link to Item
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Pereira, Thiago A., Rafal P. Witek, Wing-Kin Syn, Steve S. Choi, Youngmi Jung, Gamze F. Karaca, Alessia Omenetti, Fausto E. Pereira, and Anna Mae Diehl. “HEDGEHOG SIGNALING, STELLATE CELL/ENDOTHELIAL CELL CROSS-TALK AND PROGRESSION OF VIRAL HEPATITIS.” In Hepatology, 50:935A-935A. JOHN WILEY & SONS INC, 2009.Link to Item
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Syn, Wing-Kin, Ye Htun Oo, Rafal P. Witek, Thiago A. Pereira, Youngmi Jung, Gamze F. Karaca, Alessia Omenetti, et al. “HEDGEHOG-RELATED ACCUMULATION OF NKT CELLS PROMOTES FIBROGENESIS IN PROGRESSIVE NON ALCOHOLIC FATTY LIVER DISEASE.” In Hepatology, 50:351A-351A. JOHN WILEY & SONS INC, 2009.Link to Item
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Teaberry, Vanessa S., Gamze F. Karaca, Rafal P. Witek, Wing-Kin Syn, Alessia Omenetti, Youngmi Jung, Steve S. Choi, and Anna Mae Diehl. “NOVEL ROLE FOR HEDGEHOG PATHWAY ACTIVATION IN THE PATHOGENESIS OF PRIMARY SCLEROSING CHOLANGITIS.” In Hepatology, 50:995A-995A. JOHN WILEY & SONS INC, 2009.Link to Item
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Witek, Rafal P., Thiago A. Pereira, Wing-Kin Syn, Youngmi Jung, Kolade M. Agboolo, Steve S. Choi, and Anna Mae Diehl. “TRANSIENT HEDGEHOG PATHWAY ACTIVATION AND ACCUMULATION OF HEDGEHOG-RESPONSIVE MYOFIBROBLASTS PRECEDE EXPANSION OF LIVER EPITHELIAL PROGENITORS AFTER ACUTE CARBON TETRACHLORIDE INJURY.” In Hepatology, 50:822A-822A. JOHN WILEY & SONS INC, 2009.Link to Item
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Omenetti, Alessia, Liu Yang, Raul R. Gainetdinov, Steve S. Choi, Rafal P. Witek, Youngmi Jung, Wing-Kin Syn, Wei Chen, Marc G. Caron, and Anna Mae Diehl. “Myofibroblasts Promote the Growth of Biliary Tree During Cholestatic Liver Injury By Suppressing Tryptophan Hydroxylase 2 (TPH2) Expression and Serotonin Secretion in Neighboring Cholangiocytese.” In Gastroenterology, 136:A800–A800. W B SAUNDERS CO-ELSEVIER INC, 2009.Link to Item
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Choi, Steve S., Rafal P. Witek, Alessia Omenetti, Liu Yang, Wing-Kin Syn, Youngmi Jung, Jason K. Sicklick, and Anna Mae Diehl. “Sustained Activation of RAC1 Enhances Hedgehog-Mediated Epithelial-Mesenchymal Transition in Mice with Chronic Liver Injury.” In Gastroenterology, 136:A792–A792, 2009.Link to Item
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Jung, Youngmi, Rafal P. Witek, Wing-Kin Syn, Steve S. Choi, Alessia Omenetti, and Anna Mae Diehl. “Specific Inhibition of Ikk beta in Hepatocytes Induces Proliferation of Liver Progenitors in Injured Livers.” In Gastroenterology, 136:A789–A789, 2009.Link to Item
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Choi, Steve S., Alessia Omenetti, Rafal P. Witek, Xiu-Rong Ren, Liu Yang, Wing-Kin Syn, Jason K. Sicklick, Youngmi Jung, Wei Chen, and Anna Mae Diehl. “SUSTAINED ACTIVATION OF RAC1 ENHANCES HEDGEHOG-MEDIATED EPITHELIAL-MESENCHYMAL TRANSITION IN CULTURED RAT HEPATIC STELLATE CELLS.” In Hepatology, 48:380A-381A. JOHN WILEY & SONS INC, 2008.Link to Item
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Moylan, Cynthia A., Steve S. Choi, Chaitanya R. Acharya, Kelly Salter, Andrew J. Muir, Anil Potti, and Anna Mae Diehl. “GENE EXPRESSION PROFILES COUPLED WITH SIGNATURES OF ONCOGENIC PATHWAY DYSREGULATION PROVIDE A RATIONAL APPROACH TO DISSECTING THE MOLECULAR HETEROGENEITY OF HEPATOCELLULAR CARCINOMA.” In Hepatology, 48:1120A-1120A. JOHN WILEY & SONS INC, 2008.Link to Item
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Omenetti, Alessia, Wing-Kin Syn, Youngmi Jung, Rafal P. Witek, Steve S. Choi, M Eric Gershwin, and Anna Mae Diehl. “PARACRINE HEDGEHOG SIGNALING BETWEEN CHOLANGIOCYTES AND MYOFIBROBLASTS PROMOTES NKT CELL MIGRATION TOWARDS BILIARY EPITHELIAL CELLS: A NOVEL MECHANISM FOR NKT CELL ACCUMULATION IN PRIMARY BILIARY CIRRHOSIS.” In Hepatology, 48:595A-596A. JOHN WILEY & SONS INC, 2008.Link to Item
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Syn, Wing-Kin, Liu Yang, Youngmi Jung, Rafal P. Witek, Steve S. Choi, Alessia Omenetti, and Anna Mae Diehl. “HEDGEHOG PATHWAY ACTIVATION PROMOTES HEPATIC FIBROSIS IN MICE WITH DIET-INDUCED NON-ALCOHOLIC STEATOHEPATITIS.” In Hepatology, 48:828A-829A. JOHN WILEY & SONS INC, 2008.Link to Item
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Syn, Wing-Kin, Rafal P. Witek, Youngmi Jung, Steve S. Choi, Alessia Omenetti, and Anna Mae Diehl. “HEDGEHOG ACTIVATES AND MODULATES HEPATIC INVARIANT NKT (INKT) RESPONSES.” In Hepatology, 48:1001A-1001A. JOHN WILEY & SONS INC, 2008.Link to Item
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Witek, Rafal P., Renshui Liu, Wing-Kin Syn, Youngmi Jung, Alessia Omenetti, Liu Yang, Steve S. Choi, Wei Chen, and Anna Mae Diehl. “EXOSOMES RELEASED BY HEPATIC STELLATE CELLS AND IMMATURE BILIARY EPITHELIAL CELLS CONTAIN BIOLOGICALLY-ACTIVE HEDGEHOG LIGANDS.” In Hepatology, 48:407A-407A. JOHN WILEY & SONS INC, 2008.Link to Item
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Choi, Steve S., Alessia Omenetti, Liu Yang, Rafal P. Witek, Kevin D. Brown, Mercedes Vazquez-Chantada, Jiawen Huang, et al. “Culture activation of murine hepatic stellate cells involves hedgehog pathway activation and epithelial-to-mesenchymal transitions.” In Gastroenterology, 134:A797–A797, 2008.Link to Item
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Omenetti, Alessia, Alessandro Porrello, Wing-Kin Syn, Steve S. Choi, Youngmi Jung, Liu Yang, Kevin D. Brown, Rafal P. Witek, Hendrika Vandongen, and Anna Mae Diehl. “Myofibroblast-derived soluble factors upregulate chemokine gene expression in neighboring cholangiocytes.” In Gastroenterology, 134:A776–A776, 2008.Link to Item
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Witek, Rafal P., Renshui Liu, Liu Yang, Youngmi Jung, Kevin Brown, Alessia Omenetti, Mercedes Vazquez-Chantada, et al. “Liver-derived microparticles carry biologically-active Hedgehog morphogens, in blood and bile.” In Gastroenterology, 134:A570–A570, 2008.Link to Item
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Yang, Liu, Youngmi Jung, Jiawen Huang, Alessia Omenetti, Rafal P. Witek, Steve S. Choi, Gianfranco Alpini, and Anna Mae Diehl. “Glial fibrillary acidic protein(+) progenitors regenerate adult livers.” In Gastroenterology, 134:A768–69, 2008.Link to Item
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Omenetti, Alessia, Yin-Xiong Li, Liu Yang, Jason K. Sicklick, Steve Choi, Ayako Suzuki, and Anna Mae Diehl. “Mesenchymal-epithelial signalling by the Hedgehog pathway promotes proliferation of bile ductular cells.” In Hepatology, 44:389A-389A. WILEY-BLACKWELL, 2006.Link to Item
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Batavia, A., E. Hernandez-Perez, M. Bustamante, J. A. Dominguez-Rosales, J. K. Sicklick, S. S. Choi, Q. Ma, P. J. Goldshmidt-Clermont, A. M. Dieh, and M. Rojkind. “Oxidative stress mediates the transformation of rodent hepatic stellate cells to myoribroblasts in culture.” In Faseb Journal, 20:A630–31. FEDERATION AMER SOC EXP BIOL, 2006.Link to Item
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Long, Lingyun, Yi Qi, Jason K. Sicklick, Steve S. Choi, Liu Yang, and Anna Mae Diehl. “Hepatic stellate cell production of resistin modulates liver insulin sensitivity.” In Gastroenterology, 130:A751–A751, 2006.Link to Item
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Omenetti, Alessia, Yi Qi, Jason K. Sicklick, Steve S. Choi, Yin-Xiong Li, and Anna Mae Diehl. “Co-culture of hepatic stellate cells and cholangiocytes increases cell proliferation via autocrine/paracrine signaling.” In Gastroenterology, 130:A817–A817, 2006.Link to Item
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Sicklick, Jason K., Steve S. Choi, Shannon J. McCall, Elizabeth Hemandez-Perez, Marcia Bustamante, Marcos Rojkind, and Anna Mae Diehl. “Overlapping expression profile for hepatic epithelial progenitors and hepatic stellate cells.” In Gastroenterology, 130:A834–A834, 2006.Link to Item
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Suzuki, Ayako, Martin Binks, Steve S. Choi, Ron Sha, Robi Gaswarm, Eric Westman, Howard Eisenson, and Anna Mae Diehl. “Short-term effect of diets of varied carbohydrate content on hypertransaminasemia in a residential weight loss program.” In Gastroenterology, 130:A819–A819, 2006.Link to Item
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Sicklick, J. K., M. Rojkind, Y. Qi, W. Chen, M. Bustamante, S. S. Choi, J. W. Huang, et al. “Hedgehog signaling in hepatic stellate cells from adult mice and rats.” In Hepatology, 42:733A-733A. JOHN WILEY & SONS INC, 2005.Link to Item
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Choi, S. S., J. W. Huang, J. K. Sicklick, Q. Ma, J. T. Camp, P. J. Goldschmidt-Clermont, and A. M. Diehl. “Rac over-expression in activated hepatic stellate cells increases susceptibility to liver injury.” In Hepatology, 42:267A-267A. JOHN WILEY & SONS INC, 2005.Link to Item
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