Steven Sok Choi | Scholars@Duke

Steven Sok Choi
Associate Professor of Medicine

Hepatic stellate cell biology; Hepatic Fibrogenesis; Liver regeneration

Current Appointments & Affiliations

Associate Professor of Medicine, Medicine, Gastroenterology, Medicine 2017

Contact Information

Durham VA Medical Center, 508 Fulton Street, 111e, Gi Clinic, Durham, NC 27705
Durham VA Medical Center, 508 Fulton Street, 111e, Gi Clinic, Durham, NC 27705
(919) 286-6945

Background
Education, Training, & Certifications
- Fellow in Gastroenterology, Medicine, Duke University 2004 - 2007
- Medical Resident, Medicine, Duke University 2001 - 2004
- M.B.B.S., Flinders University 1999
Duke Appointment History
- Assistant Professor of Medicine, Medicine, Gastroenterology, Medicine 2016 - 2017
- Assistant Professor of Medicine, Medicine, Gastroenterology, Medicine 2008 - 2016
- Medical Instructor in the Department of Medicine, Medicine, Gastroenterology, Medicine 2007 - 2008
Expertise
Subject Headings
Research
Selected Grants
- A systemically deliverable, RNAi-based approach for alcoholic liver disease awarded by Extend Biosciences 2014 - 2016
- Rac1 Promotes Hepatic Stellate Accumulation/Activation in Liver Injury awarded by National Institutes of Health 2009 - 2014
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Lewis, DS, Lee, T-H, Konanur, M, Ziegler, C, Hall, MD, Pabon-Ramos, WM, Suhocki, PV, Smith, TP, Kim, CY, Choi, SS, and Ronald, J. "Proton Pump Inhibitor Use Is Associated with an Increased Frequency of New or Worsening Hepatic Encephalopathy after Transjugular Intrahepatic Portosystemic Shunt Creation." Journal of Vascular and Interventional Radiology : Jvir 30, no. 2 (February 2019): 163-169. Full Text
  - Ronald, J, Rao, R, Choi, SS, Kappus, M, Martin, JG, Sag, AA, Pabon-Ramos, WM, Suhocki, PV, Smith, TP, and Kim, CY. "No Increased Mortality After TIPS Compared with Serial Large Volume Paracenteses in Patients with Higher Model for End-Stage Liver Disease Score and Refractory Ascites." Cardiovascular and Interventional Radiology (January 2, 2019). Full Text
  - Wilder, J, Choi, SS, and Moylan, CA. "Vibration-Controlled Transient Elastography for Diagnosing Cirrhosis and Staging Hepatic Fibrosis." Jama 320, no. 19 (November 2018): 2031-2032. Full Text
  - Patel, YA, Gifford, EJ, Glass, LM, Turner, MJ, Han, B, Moylan, CA, Choi, S, Suzuki, A, Provenzale, D, and Hunt, CM. "Correction to: Identifying Nonalcoholic Fatty Liver Disease Advanced Fibrosis in the Veterans Health Administration." Digestive Diseases and Sciences 63, no. 10 (October 2018): 2813-2814. Full Text Open Access Copy
  - Chino, F, Stephens, SJ, Choi, SS, Marin, D, Kim, CY, Morse, MA, Godfrey, DJ, Czito, BG, Willett, CG, and Palta, M. "The role of external beam radiotherapy in the treatment of hepatocellular cancer." Cancer 124, no. 17 (September 2018): 3476-3489. (Review) Full Text
  - Patel, YA, Gifford, EJ, Glass, LM, Turner, MJ, Han, B, Moylan, CA, Choi, S, Suzuki, A, Provenzale, D, and Hunt, CM. "Identifying Nonalcoholic Fatty Liver Disease Advanced Fibrosis in the Veterans Health Administration." Digestive Diseases and Sciences 63, no. 9 (September 2018): 2259-2266. Full Text
  - Naggie, S, Swiderska-Syn, M, Choi, S, Lusk, S, Lan, A, Ferrari, G, Syn, W-K, Guy, CD, and Diehl, AM. "Markers of Tissue Repair and Cellular Aging Are Increased in the Liver Tissue of Patients With HIV Infection Regardless of Presence of HCV Coinfection." Open Forum Infectious Diseases 5, no. 7 (July 2018): ofy138-null. Full Text
  - Ronald, J, Wang, Q, Choi, SS, Suhocki, PV, Hall, MD, Smith, TP, and Kim, CY. "Albumin-bilirubin grade versus MELD score for predicting survival after transjugular intrahepatic portosystemic shunt (TIPS) creation." Diagnostic and Interventional Imaging 99, no. 3 (March 2018): 163-168. Full Text
  - Kasarala, G, Choi, S, Lopez, K, Britt, RB, Boatright, C, and Tillmann, HL. "Curing hepatitis C virus (HCV) after organ transplantation: Increased risk of rejection following HCV elimination." Transplant Infectious Disease : an Official Journal of the Transplantation Society 20, no. 1 (February 2018). (Letter) Full Text
  - Patel, YA, Gifford, EJ, Glass, LM, McNeil, R, Turner, MJ, Han, B, Provenzale, D, Choi, SS, Moylan, CA, and Hunt, CM. "Risk factors for biopsy-proven advanced non-alcoholic fatty liver disease in the Veterans Health Administration." Alimentary Pharmacology & Therapeutics 47, no. 2 (January 2018): 268-278. Full Text
  - Chan, AW, Patel, YA, and Choi, S. "Aging of the Liver: What This Means for Patients with HIV." Current HIV/AIDS reports 13, no. 6 (December 2016): 309-317. (Review) Full Text
  - Michelotti, GA, Tucker, A, Swiderska-Syn, M, Machado, MV, Choi, SS, Kruger, L, Soderblom, E, Thompson, JW, Mayer-Salman, M, Himburg, HA, Moylan, CA, Guy, CD, Garman, KS, Premont, RT, Chute, JP, and Diehl, AM. "Pleiotrophin regulates the ductular reaction by controlling the migration of cells in liver progenitor niches." Gut 65, no. 4 (April 2016): 683-692. Full Text Open Access Copy
  - Michelotti, GA, Tucker, A, Swiderska-Syn, M, Machado, MV, Choi, SS, Kruger, L, Soderblom, E, Thompson, JW, Mayer-Salman, M, Himburg, HA, Moylan, CA, Guy, CD, Garman, KS, Premont, RT, Chute, JP, and Diehl, AM. "Pleiotrophin regulates the ductular reaction by controlling the migration of cells in liver progenitor niches." GUT 65, no. 4 (April 2016): 683-692. Full Text Link to Item
  - Coombes, JD, Choi, SS, Swiderska-Syn, M, Manka, P, Reid, DT, Palma, E, Briones-Orta, MA, Xie, G, Younis, R, Kitamura, N, Della Peruta, M, Bitencourt, S, Dollé, L, Oo, YH, Mi, Z, Kuo, PC, Williams, R, Chokshi, S, Canbay, A, Claridge, LC, Eksteen, B, Diehl, AM, and Syn, W-K. "Osteopontin is a proximal effector of leptin-mediated non-alcoholic steatohepatitis (NASH) fibrosis." Biochimica Et Biophysica Acta 1862, no. 1 (January 2016): 135-144. Full Text
  - Pereira, TA, Syn, W-K, Machado, MV, Vidigal, PV, Resende, V, Voieta, I, Xie, G, Otoni, A, Souza, MM, Santos, ET, Chan, IS, Trindade, GVM, Choi, SS, Witek, RP, Pereira, FE, Secor, WE, Andrade, ZA, Lambertucci, JR, and Diehl, AM. "Schistosome-induced cholangiocyte proliferation and osteopontin secretion correlate with fibrosis and portal hypertension in human and murine schistosomiasis mansoni." Clinical Science (London, England : 1979) 129, no. 10 (November 2015): 875-883. Full Text Open Access Copy
  - Uschner, FE, Ranabhat, G, Choi, SS, Granzow, M, Klein, S, Schierwagen, R, Raskopf, E, Gautsch, S, van der Ven, PFM, Fürst, DO, Strassburg, CP, Sauerbruch, T, Diehl, AM, and Trebicka, J. "Statins activate the canonical hedgehog-signaling and aggravate non-cirrhotic portal hypertension, but inhibit the non-canonical hedgehog signaling and cirrhotic portal hypertension." Scientific reports 5 (September 28, 2015): 14573-. Full Text
  - Coombes, JD, Swiderska-Syn, M, Dollé, L, Reid, D, Eksteen, B, Claridge, L, Briones-Orta, MA, Shetty, S, Oo, YH, Riva, A, Chokshi, S, Papa, S, Mi, Z, Kuo, PC, Williams, R, Canbay, A, Adams, DH, Diehl, AM, van Grunsven, LA, Choi, SS, and Syn, WK. "Osteopontin neutralisation abrogates the liver progenitor cell response and fibrogenesis in mice." Gut 64, no. 7 (July 2015): 1120-1131. Full Text
  - Karaca, G, Xie, G, Moylan, C, Swiderska-Syn, M, Guy, CD, Krüger, L, Machado, MV, Choi, SS, Michelotti, GA, Burkly, LC, and Diehl, AM. "Role of Fn14 in acute alcoholic steatohepatitis in mice." American Journal of Physiology. Gastrointestinal and Liver Physiology 308, no. 4 (February 2015): G325-G334. Full Text
  - Coombes, JD, Swiderska-Syn, M, Dollé, L, Reid, D, Eksteen, B, Claridge, L, Briones-Orta, MA, Shetty, S, Oo, YH, Riva, A, Chokshi, S, Papa, S, Mi, Z, Kuo, PC, Williams, R, Canbay, A, Adams, DH, Diehl, AM, Grunsven, LAV, Choi, SS, and Syn, WK. "Osteopontin neutralisation abrogates the liver progenitor cell response and fibrogenesis in mice." Gut 64, no. 7 (2015): 1120-1131. Full Text
  - Kim, J, Wang, S, Hyun, J, Choi, SS, Cha, H, Ock, M, and Jung, Y. "Hepatic stellate cells express thymosin Beta 4 in chronically damaged liver." Plos One 10, no. 3 (January 2015): e0122758-null. Full Text Open Access Copy
  - Swiderska-Syn, M, Syn, WK, Xie, G, Krüger, L, Machado, MV, Karaca, G, Michelotti, GA, Choi, SS, Premont, RT, and Diehl, AM. "Myofibroblastic cells function as progenitors to regenerate murine livers after partial hepatectomy." Gut 63, no. 8 (August 2014): 1333-1344. Full Text Link to Item
  - Choi, SS, Claridge, LC, Jhaveri, R, Swiderska-Syn, M, Clark, P, Suzuki, A, Pereira, TA, Mi, Z, Kuo, PC, Guy, CD, Pereira, FEL, Diehl, AM, Patel, K, and Syn, W-K. "Osteopontin is up-regulated in chronic hepatitis C and is associated with cellular permissiveness for hepatitis C virus replication." Clinical Science (London, England : 1979) 126, no. 12 (June 2014): 845-855. Full Text
  - Chan, IS, Guy, CD, Machado, MV, Wank, A, Kadiyala, V, Michelotti, G, Choi, S, Swiderska-Syn, M, Karaca, G, Pereira, TA, Yip-Schneider, MT, Max Schmidt, C, and Diehl, AM. "Alcohol activates the hedgehog pathway and induces related procarcinogenic processes in the alcohol-preferring rat model of hepatocarcinogenesis." Alcohol Clin Exp Res 38, no. 3 (March 2014): 787-800. Full Text Link to Item
  - Hyun, J, Choi, SS, Diehl, AM, and Jung, Y. "Potential role of Hedgehog signaling and microRNA-29 in liver fibrosis of IKKβ-deficient mouse." Journal of Molecular Histology 45, no. 1 (February 1, 2014): 103-112. Full Text
  - Hyun, J, Choi, SS, Diehl, AM, and Jung, Y. "Potential role of Hedgehog signaling and microRNA-29 in liver fibrosis of IKKβ-deficient mouse." Journal of Molecular Histology 45, no. 1 (February 2014): 103-112. Full Text
  - Moylan, CA, Pang, H, Dellinger, A, Suzuki, A, Garrett, ME, Guy, CD, Murphy, SK, Ashley-Koch, AE, Choi, SS, Michelotti, GA, Hampton, DD, Chen, Y, Tillmann, HL, Hauser, MA, Abdelmalek, MF, and Diehl, AM. "Hepatic gene expression profiles differentiate presymptomatic patients with mild versus severe nonalcoholic fatty liver disease." Hepatology 59, no. 2 (February 2014): 471-482. Full Text Link to Item
  - Karaca, G, Swiderska-Syn, M, Xie, G, Syn, W-K, Krüger, L, Machado, MV, Garman, K, Choi, SS, Michelotti, GA, Burkly, LC, Ochoa, B, and Diehl, AM. "TWEAK/Fn14 signaling is required for liver regeneration after partial hepatectomy in mice." Plos One 9, no. 1 (January 9, 2014): e83987-null. Full Text Open Access Copy
  - Chan, IS, Guy, CD, Machado, MV, Wank, A, Kadiyala, V, Michelotti, G, Choi, S, Swiderska-Syn, M, Karaca, G, Pereira, TA, Yip-Schneider, MT, Max Schmidt, C, and Diehl, AM. "Alcohol activates the hedgehog pathway and induces related procarcinogenic processes in the alcohol-preferring rat model of hepatocarcinogenesis." Alcoholism: Clinical and Experimental Research 38, no. 3 (January 1, 2014): 787-800. Full Text
  - Swiderska-Syn, M, Syn, WK, Xie, G, Krüger, L, Machado, MV, Karaca, G, Michelotti, GA, Choi, SS, Premont, RT, and Diehl, AM. "Myofibroblastic cells function as progenitors to regenerate murine livers after partial hepatectomy." Gut 63, no. 8 (January 1, 2014): 1333-1344. Full Text
  - Xie, G, Karaca, G, Swiderska-Syn, M, Michelotti, GA, Krüger, L, Chen, Y, Premont, RT, Choi, SS, and Diehl, AM. "Cross-talk between Notch and Hedgehog regulates hepatic stellate cell fate in mice." Hepatology 58, no. 5 (November 1, 2013): 1801-1813. Full Text
  - Xie, G, Karaca, G, Swiderska-Syn, M, Michelotti, GA, Krüger, L, Chen, Y, Premont, RT, Choi, SS, and Diehl, AM. "Cross-talk between Notch and Hedgehog regulates hepatic stellate cell fate in mice." Hepatology (Baltimore, Md.) 58, no. 5 (November 2013): 1801-1813. Full Text
  - Michelotti, GA, Xie, G, Swiderska, M, Choi, SS, Karaca, G, Krüger, L, Premont, R, Yang, L, Syn, W-K, Metzger, D, and Diehl, AM. "Smoothened is a master regulator of adult liver repair." The Journal of Clinical Investigation 123, no. 6 (June 2013): 2380-2394. Full Text
  - Xie, G, Choi, SS, Syn, W-K, Michelotti, GA, Swiderska, M, Karaca, G, Chan, IS, Chen, Y, and Diehl, AM. "Hedgehog signalling regulates liver sinusoidal endothelial cell capillarisation." Gut 62, no. 2 (February 2013): 299-309. Full Text Link to Item
  - Pereira, TA, Xie, G, Choi, SS, Syn, W-K, Voieta, I, Lu, J, Chan, IS, Swiderska, M, Amaral, KB, Antunes, CM, Secor, WE, Witek, RP, Lambertucci, JR, Pereira, FL, and Diehl, AM. "Macrophage-derived Hedgehog ligands promotes fibrogenic and angiogenic responses in human schistosomiasis mansoni." Liver Int 33, no. 1 (January 2013): 149-161. Full Text Link to Item
  - Xie, G, Choi, SS, Syn, W-K, Michelotti, GA, Swiderska, M, Karaca, G, Chan, IS, Chen, Y, and Diehl, AM. "Hedgehog signalling regulates liver sinusoidal endothelial cell capillarisation." Gut 62, no. 2 (2013): 299-309. Full Text
  - Chan, IS, Guy, CD, Chen, Y, Lu, J, Swiderska-Syn, M, Michelotti, GA, Karaca, G, Xie, G, Krüger, L, Syn, W-K, Anderson, BR, Pereira, TA, Choi, SS, Baldwin, AS, and Diehl, AM. "Paracrine Hedgehog signaling drives metabolic changes in hepatocellular carcinoma." Cancer Research 72, no. 24 (December 2012): 6344-6350. Full Text
  - Tillman, HL, and Choi, SS. "Risk for Hepatocellular Carcinoma in Patients With Alcoholic Cirrhosis." ANNALS OF INTERNAL MEDICINE 157, no. 9 (November 6, 2012): 677-678. Full Text Link to Item
  - Arzumanyan, A, Sambandam, V, Clayton, MM, Choi, SS, Xie, G, Diehl, AM, Yu, D-Y, and Feitelson, MA. "Hedgehog signaling blockade delays hepatocarcinogenesis induced by hepatitis B virus X protein." Cancer Research 72, no. 22 (November 2012): 5912-5920. Full Text
  - Chen, Y, Choi, SS, Michelotti, GA, Chan, IS, Swiderska-Syn, M, Karaca, GF, Xie, G, Moylan, CA, Garibaldi, F, Premont, R, Suliman, HB, Piantadosi, CA, and Diehl, AM. "Hedgehog controls hepatic stellate cell fate by regulating metabolism." Gastroenterology 143, no. 5 (November 2012): 1319-1329.e11. Full Text
  - Syn, W-K, Agboola, KM, Swiderska, M, Michelotti, GA, Liaskou, E, Pang, H, Xie, G, Philips, G, Chan, IS, Karaca, GF, Pereira, TDA, Chen, Y, Mi, Z, Kuo, PC, Choi, SS, Guy, CD, Abdelmalek, MF, and Diehl, AM. "NKT-associated hedgehog and osteopontin drive fibrogenesis in non-alcoholic fatty liver disease." Gut 61, no. 9 (September 2012): 1323-1329. Full Text
  - Syn, W-K, Agboola, KM, Swiderska, M, Michelotti, GA, Liaskou, E, Pang, H, Xie, G, Philips, G, Chan, IS, Karaca, GF, Pereira, TDA, Chen, Y, Mi, Z, Kuo, PC, Choi, SS, Guy, CD, Abdelmalek, MF, and Diehl, AM. "NKT-associated hedgehog and osteopontin drive fibrogenesis in non-alcoholic fatty liver disease." Gut 61, no. 9 (September 2012): 1323-1329. Full Text
  - Liaskou, E, Zimmermann, H, Stamataki, Z, Qureshi, O, Choi, SS, Shaw, J, Curbishley, SM, Syn, WK, and Adams, DH. "PMO-119 Phenotypically and functionally distinct monocyte subsets and their role in human liver disease." Gut 61, no. Suppl 2 (July 2012): A121.1-A121. Full Text
  - Romac, JM-J, Shahid, RA, Choi, SS, Karaca, GF, Westphalen, CB, Wang, TC, and Liddle, RA. "Pancreatic secretory trypsin inhibitor I reduces the severity of chronic pancreatitis in mice overexpressing interleukin-1β in the pancreas." American Journal of Physiology. Gastrointestinal and Liver Physiology 302, no. 5 (March 2012): G535-G541. Full Text
  - Choi, S, and Diehl, AM. "After goodbye? Dead hepatocytes as a biomarker for fibrosis and steatohepatitis." Hepatology 55, no. 2 (2012): 333-335. Full Text
  - Choi, SS, Bradrick, S, Qiang, G, Mostafavi, A, Chaturvedi, G, Weinman, SA, Diehl, AM, and Jhaveri, R. "Up-regulation of Hedgehog pathway is associated with cellular permissiveness for hepatitis C virus replication." Hepatology (Baltimore, Md.) 54, no. 5 (November 2011): 1580-1590. Full Text
  - Omenetti, A, Bass, LM, Anders, RA, Clemente, MG, Francis, H, Guy, CD, McCall, S, Choi, SS, Alpini, G, Schwarz, KB, Diehl, AM, and Whitington, PF. "Hedgehog activity, epithelial-mesenchymal transitions, and biliary dysmorphogenesis in biliary atresia." Hepatology (Baltimore, Md.) 53, no. 4 (April 2011): 1246-1258. Full Text
  - Choi, SS, Omenetti, A, Syn, W-K, and Diehl, AM. "The role of Hedgehog signaling in fibrogenic liver repair." The International Journal of Biochemistry & Cell Biology 43, no. 2 (February 2011): 238-244. (Review) Full Text
  - Omenetti, A, Choi, S, Michelotti, G, and Diehl, AM. "Hedgehog signaling in the liver." Journal of Hepatology 54, no. 2 (February 2011): 366-373. (Review) Full Text
  - Omenetti, A, Yang, L, Gainetdinov, RR, Guy, CD, Choi, SS, Chen, W, Caron, MG, and Diehl, AM. "Paracrine modulation of cholangiocyte serotonin synthesis orchestrates biliary remodeling in adults." American Journal of Physiology. Gastrointestinal and Liver Physiology 300, no. 2 (February 2011): G303-G315. Full Text
  - Philips, GM, Chan, IS, Swiderska, M, Schroder, VT, Guy, C, Karaca, GF, Moylan, C, Venkatraman, T, Feuerlein, S, Syn, W-K, Jung, Y, Witek, RP, Choi, S, Michelotti, GA, Rangwala, F, Merkle, E, Lascola, C, and Diehl, AM. "Hedgehog signaling antagonist promotes regression of both liver fibrosis and hepatocellular carcinoma in a murine model of primary liver cancer." Plos One 6, no. 9 (January 2011): e23943-null. Full Text Open Access Copy
  - Syn, W-K, Choi, SS, Liaskou, E, Karaca, GF, Agboola, KM, Oo, YH, Mi, Z, Pereira, TA, Zdanowicz, M, Malladi, P, Chen, Y, Moylan, C, Jung, Y, Bhattacharya, SD, Teaberry, V, Omenetti, A, Abdelmalek, MF, Guy, CD, Adams, DH, Kuo, PC, Michelotti, GA, Whitington, PF, and Diehl, AM. "Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis." Hepatology (Baltimore, Md.) 53, no. 1 (January 2011): 106-115. Full Text
  - Pereira, TDA, Witek, RP, Syn, W-K, Choi, SS, Bradrick, S, Karaca, GF, Agboola, KM, Jung, Y, Omenetti, A, Moylan, CA, Yang, L, Fernandez-Zapico, ME, Jhaveri, R, Shah, VH, Pereira, FE, and Diehl, AM. "Viral factors induce Hedgehog pathway activation in humans with viral hepatitis, cirrhosis, and hepatocellular carcinoma." Laboratory Investigation; a Journal of Technical Methods and Pathology 90, no. 12 (December 2010): 1690-1703. Full Text Open Access Copy
  - Choi, SS, Syn, W-K, Karaca, GF, Omenetti, A, Moylan, CA, Witek, RP, Agboola, KM, Jung, Y, Michelotti, GA, and Diehl, AM. "Leptin promotes the myofibroblastic phenotype in hepatic stellate cells by activating the hedgehog pathway." The Journal of Biological Chemistry 285, no. 47 (November 2010): 36551-36560. Full Text
  - Choi, SS, Witek, RP, Yang, L, Omenetti, A, Syn, W-K, Moylan, CA, Jung, Y, Karaca, GF, Teaberry, VS, Pereira, TA, Wang, J, Ren, X-R, and Diehl, AM. "Activation of Rac1 promotes hedgehog-mediated acquisition of the myofibroblastic phenotype in rat and human hepatic stellate cells." Hepatology 52, no. 1 (July 2010): 278-290. Full Text Link to Item
  - Syn, W-K, Oo, YH, Pereira, TA, Karaca, GF, Jung, Y, Omenetti, A, Witek, RP, Choi, SS, Guy, CD, Fearing, CM, Teaberry, V, Pereira, FEL, Adams, DH, and Diehl, AM. "Accumulation of natural killer T cells in progressive nonalcoholic fatty liver disease." Hepatology (Baltimore, Md.) 51, no. 6 (June 2010): 1998-2007. Full Text
  - Jung, Y, Witek, RP, Syn, W-K, Choi, SS, Omenetti, A, Premont, R, Guy, CD, and Diehl, AM. "Signals from dying hepatocytes trigger growth of liver progenitors." Gut 59, no. 5 (May 2010): 655-665. Full Text Link to Item
  - Ochoa, B, Syn, W-K, Delgado, I, Karaca, GF, Jung, Y, Wang, J, Zubiaga, AM, Fresnedo, O, Omenetti, A, Zdanowicz, M, Choi, SS, and Diehl, AM. "Hedgehog signaling is critical for normal liver regeneration after partial hepatectomy in mice." Hepatology (Baltimore, Md.) 51, no. 5 (May 2010): 1712-1723. Full Text
  - McGoogan, KE, Smith, PB, Choi, SS, Berman, W, and Jhaveri, R. "Performance of the AST-to-platelet ratio index as a noninvasive marker of fibrosis in pediatric patients with chronic viral hepatitis." Journal of Pediatric Gastroenterology and Nutrition 50, no. 3 (March 2010): 344-346. Full Text
  - Choi, SS, Omenetti, A, Witek, RP, Moylan, CA, Syn, W-K, Jung, Y, Yang, L, Sudan, DL, Sicklick, JK, Michelotti, GA, Rojkind, M, and Diehl, AM. "Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis." American Journal of Physiology. Gastrointestinal and Liver Physiology 297, no. 6 (December 2009): G1093-G1106. Full Text
  - Choi, SS, and Diehl, AM. "Epithelial-to-mesenchymal transitions in the liver." Hepatology (Baltimore, Md.) 50, no. 6 (December 2009): 2007-2013. (Review) Full Text
  - Syn, W-K, Choi, SS, and Diehl, AM. "Apoptosis and cytokines in non-alcoholic steatohepatitis." Clinics in Liver Disease 13, no. 4 (November 2009): 565-580. Full Text
  - Witek, RP, Stone, WC, Karaca, FG, Syn, W-K, Pereira, TA, Agboola, KM, Omenetti, A, Jung, Y, Teaberry, V, Choi, SS, Guy, CD, Pollard, J, Charlton, P, and Diehl, AM. "Pan-caspase inhibitor VX-166 reduces fibrosis in an animal model of nonalcoholic steatohepatitis." Hepatology (Baltimore, Md.) 50, no. 5 (November 2009): 1421-1430. Full Text
  - Syn, W-K, Jung, Y, Omenetti, A, Abdelmalek, M, Guy, CD, Yang, L, Wang, J, Witek, RP, Fearing, CM, Pereira, TA, Teaberry, V, Choi, SS, Conde-Vancells, J, Karaca, GF, and Diehl, AM. "Hedgehog-mediated epithelial-to-mesenchymal transition and fibrogenic repair in nonalcoholic fatty liver disease." Gastroenterology 137, no. 4 (October 2009): 1478-1488.e8. Full Text Link to Item
  - Syn, W-K, Yang, L, Chiang, DJ, Qian, Y, Jung, Y, Karaca, G, Choi, SS, Witek, RP, Omenetti, A, Pereira, TA, and Diehl, AM. "Genetic differences in oxidative stress and inflammatory responses to diet-induced obesity do not alter liver fibrosis in mice." Liver Int 29, no. 8 (September 2009): 1262-1272. Full Text Link to Item
  - Omenetti, A, Syn, W-K, Jung, Y, Francis, H, Porrello, A, Witek, RP, Choi, SS, Yang, L, Mayo, MJ, Gershwin, ME, Alpini, G, and Diehl, AM. "Repair-related activation of hedgehog signaling promotes cholangiocyte chemokine production." Hepatology 50, no. 2 (August 2009): 518-527. Full Text Link to Item
  - Syn, W-K, Witek, RP, Curbishley, SM, Jung, Y, Choi, SS, Enrich, B, Omenetti, A, Agboola, KM, Fearing, CM, Tilg, H, Adams, DH, and Diehl, AM. "Role for hedgehog pathway in regulating growth and function of invariant NKT cells." European Journal of Immunology 39, no. 7 (July 2009): 1879-1892. Full Text
  - Syn, W-K, Teaberry, V, Choi, SS, and Diehl, AM. "Similarities and differences in the pathogenesis of alcoholic and nonalcoholic steatohepatitis." Semin Liver Dis 29, no. 2 (May 2009): 200-210. (Review) Full Text Link to Item
  - Miller, MW, Basra, S, Kulp, DW, Billings, PC, Choi, S, Beavers, MP, McCarty, OJT, Zou, Z, Kahn, ML, Bennett, JS, and DeGrado, WF. "Small-molecule inhibitors of integrin alpha2beta1 that prevent pathological thrombus formation via an allosteric mechanism." Proc Natl Acad Sci U S A 106, no. 3 (January 20, 2009): 719-724. Full Text Link to Item
  - Omenetti, A, Syn, W-K, Jung, Y, Witek, RP, Choi, SS, and Diehl, AM. "MYOFIBROBLASTS PROVIDE HEDGEHOG PARACRINE SIGNALS THAT DRIVE CHOLANGIOCYTES TO RECRUIT NKT CELLS TO PORTAL TRACTS." JOURNAL OF HEPATOLOGY 50 (2009): S31-S32. Full Text Link to Item
  - Witek, RP, Yang, L, Liu, R, Jung, Y, Omenetti, A, Syn, W-K, Choi, SS, Cheong, Y, Fearing, CM, Agboola, KM, Chen, W, and Diehl, AM. "Liver cell-derived microparticles activate hedgehog signaling and alter gene expression in hepatic endothelial cells." Gastroenterology 136, no. 1 (January 2009): 320-330.e2. Full Text
  - Jou, J, Choi, SS, and Diehl, AM. "Mechanisms of disease progression in nonalcoholic fatty liver disease." Seminars in Liver Disease 28, no. 4 (November 2008): 370-379. (Review) Full Text
  - Omenetti, A, Porrello, A, Jung, Y, Yang, L, Popov, Y, Choi, SS, Witek, RP, Alpini, G, Venter, J, Vandongen, HM, Syn, W-K, Baroni, GS, Benedetti, A, Schuppan, D, and Diehl, AM. "Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans." The Journal of Clinical Investigation 118, no. 10 (October 2008): 3331-3342. Full Text
  - Omenetti, A, Popov, Y, Jung, Y, Choi, SS, Witek, RP, Yang, L, Brown, KD, Schuppan, D, and Diehl, AM. "The hedgehog pathway regulates remodelling responses to biliary obstruction in rats." Gut 57, no. 9 (September 2008): 1275-1282. Full Text
  - Yang, L, Jung, Y, Omenetti, A, Witek, RP, Choi, S, Vandongen, HM, Huang, J, Alpini, GD, and Diehl, AM. "Fate-mapping evidence that hepatic stellate cells are epithelial progenitors in adult mouse livers." Stem Cells (Dayton, Ohio) 26, no. 8 (August 2008): 2104-2113. Full Text
  - Choi, SS, and Diehl, AM. "Hepatic triglyceride synthesis and nonalcoholic fatty liver disease." Current Opinion in Lipidology 19, no. 3 (June 2008): 295-300. (Review) Full Text
  - Fleig, SV, Choi, SS, Yang, L, Jung, Y, Omenetti, A, VanDongen, HM, Huang, J, Sicklick, JK, and Diehl, AM. "Hepatic accumulation of Hedgehog-reactive progenitors increases with severity of fatty liver damage in mice." Laboratory Investigation; a Journal of Technical Methods and Pathology 87, no. 12 (December 2007): 1227-1239. Full Text
  - Omenetti, A, Yang, L, Li, Y-X, McCall, SJ, Jung, Y, Sicklick, JK, Huang, J, Choi, S, Suzuki, A, and Diehl, AM. "Hedgehog-mediated mesenchymal-epithelial interactions modulate hepatic response to bile duct ligation." Laboratory Investigation; a Journal of Technical Methods and Pathology 87, no. 5 (May 2007): 499-514. Full Text
  - Choi, SS, Sicklick, JK, Ma, Q, Yang, L, Huang, J, Qi, Y, Chen, W, Li, Y-X, Goldschmidt-Clermont, PJ, and Diehl, AM. "Sustained activation of Rac1 in hepatic stellate cells promotes liver injury and fibrosis in mice." Hepatology (Baltimore, Md.) 44, no. 5 (November 2006): 1267-1277. Full Text
  - Sicklick, JK, Choi, SS, Bustamante, M, McCall, SJ, Pérez, EH, Huang, J, Li, Y-X, Rojkind, M, and Diehl, AM. "Evidence for epithelial-mesenchymal transitions in adult liver cells." American Journal of Physiology. Gastrointestinal and Liver Physiology 291, no. 4 (October 2006): G575-G583. Full Text
  - Suzuki, A, McCall, S, Choi, SS, Sicklick, JK, Huang, J, Qi, Y, Zdanowicz, M, Camp, T, Li, Y-X, and Diehl, AM. "Interleukin-15 increases hepatic regenerative activity." Journal of Hepatology 45, no. 3 (September 2006): 410-418. Full Text
  - Choi, S, and Diehl, AM. "Role of inflammation in nonalcoholic steatohepatitis." Curr Opin Gastroenterol 21, no. 6 (November 2005): 702-707. (Review) Link to Item
  - Sicklick, JK, Li, Y-X, Choi, SS, Qi, Y, Chen, W, Bustamante, M, Huang, J, Zdanowicz, M, Camp, T, Torbenson, MS, Rojkind, M, and Diehl, AM. "Role for hedgehog signaling in hepatic stellate cell activation and viability." Laboratory Investigation; a Journal of Technical Methods and Pathology 85, no. 11 (November 2005): 1368-1380. Full Text
  - Hsieh, ST, Choi, S, Lin, WM, Chang, YC, Mcarthur, JC, and Griffin, JW. "Epidermal denervation and its effects on keratinocytes and Langerhans cells." Journal of Neurocytology 25, no. 9 (September 1996): 513-524. Full Text
  - Tucker, PC, Griffin, DE, Choi, S, Bui, N, and Wesselingh, S. "Inhibition of nitric oxide synthesis increases mortality in Sindbis virus encephalitis." J Virol 70, no. 6 (June 1996): 3972-3977. Link to Item
  - Mokhtarian, F, Wesselingh, SL, Choi, S, Maeda, A, Griffin, DE, Sobel, RA, and Grob, D. "Production and role of cytokines in the CNS of mice with acute viral encephalomyelitis." J Neuroimmunol 66, no. 1-2 (May 1996): 11-22. Link to Item
  - Rho, MB, Wesselingh, S, Glass, JD, McArthur, JC, Choi, S, Griffin, J, and Tyor, WR. "A potential role for interferon-alpha in the pathogenesis of HIV-associated dementia." Brain Behav Immun 9, no. 4 (December 1995): 366-377. Full Text Link to Item
  - Herskowitz, A, Choi, S, Ansari, AA, and Wesselingh, S. "Cytokine mRNA expression in postischemic/reperfused myocardium." The American Journal of Pathology 146, no. 2 (February 1995): 419-428.
  - Bö, L, Dawson, TM, Wesselingh, S, Mörk, S, Choi, S, Kong, PA, Hanley, D, and Trapp, BD. "Induction of nitric oxide synthase in demyelinating regions of multiple sclerosis brains." Ann Neurol 36, no. 5 (November 1994): 778-786. Full Text Link to Item
  - Wesselingh, SL, Levine, B, Fox, RJ, Choi, S, and Griffin, DE. "Intracerebral cytokine mRNA expression during fatal and nonfatal alphavirus encephalitis suggests a predominant type 2 T cell response." J Immunol 152, no. 3 (February 1, 1994): 1289-1297. Link to Item
- Book Sections
  - Choi, SS, and Diehl, AM. "Alcoholic liver disease." In Handbook of Liver Disease, 109-120. August 24, 2017. Full Text
- Conference Papers
  - Du, K, Hyun, J, Premont, RT, Choi, SS, Michelotti, GA, Swiderska-Syn, M, Dalton, GD, Thelen, E, Rizi, BS, Jung, Y, and Diehl, AM. "Hedgehog-YAP Signaling Pathway Regulates Glutaminolysis to Control Activation of Hepatic Stellate Cells." April 2018. Full Text
  - Patel, YA, Gifford, E, Glass, LM, McNeil, R, Turner, MJ, Han, B, Provenzale, DT, Choi, SS, Moylan, CA, and Hunt, CM. "Diet/exercise programs are used by only one in five severely obese patients with biopsy-defined Nonalcoholic Fatty Liver Disease (NAFLD) advanced fibrosis in the Veterans Health Administration (VHA)." October 2017. Link to Item
  - Chan, AW, Bryan, WE, Hashem, MA, Townsend, ML, Wang, LA, Choi, SS, and Naggie, S. "Hepatitis C (HCV) Virologic Outcomes in Veterans taking Ledipasvir/Sofosbuvir with Concomitant Acid Suppressing Medication." October 2016. Link to Item
  - Rabatin, A, Hashem, M, Townsend, ML, Bryan, WE, Moylan, CA, Choi, SS, and Naggie, S. "Treatment Outcomes of Veterans with Decompensated Cirrhosis Receiving All Oral Direct Acting Antiviral Hepatitis C Therapy." October 2015. Link to Item
  - Uschner, FE, Ranabhat, G, Granzow, M, Choi, SS, Klein, S, Schierwagen, R, Raskopf, E, Gautsch, S, Van der Ven, PF, Strassburg, CP, Fuerst, DO, Hiththetiya, K, Sauerbruch, T, Diehl, AM, and Trebicka, J. "Statins activate the canonical hedgehog-signaling and aggravate non-cirrhotic portal hypertension, but inhibit the non-canonical hedgehog signaling and cirrhotic portal hypertension." October 2015. Link to Item
  - Naqvi, IA, White, RR, Moylan, CA, Diehl, AM, and Choi, SS. "Abstract 4117: Utilizing RNA aptamers for biomarker discovery in a novel cell culture system for hepatocellular carcinoma." October 1, 2014. Full Text
  - Coombes, J, Swiderska-Syn, M, Dollé, L, Reid, D, Eksteen, B, Claridge, L, Briones-Orta, M, Shishir, S, Oo, Y, Riva, A, Chokshi, S, Papa, S, Mi, Z, Kuo, P, Williams, R, Canbay, A, Adams, D, van Grunsven, L, Diehl, A, Choi, S, and Syn, W-K. "P612 OSTEOPONTIN NEUTRALIZATION ABROGATES THE LIVER PROGENITOR CELL RESPONSE AND FIBROGENIC OUTCOMES IN MICE." April 2014. Full Text
  - Coombes, JD, Choi, SS, Manka, PP, Briones-Orta, MA, Swiderska-Syn, M, Kitamura, N, Younis, R, Bitencourt, S, Dolle, L, Williams, R, van Grunsven, LA, Diehl, AM, Canbay, A, and Syn, W-K. "Osteopontin mediates fibrogenic effects of leptin and enhances NASH progression." 2014. Link to Item
  - Uschner, FE, Ranabhat, G, Granzow, M, Choi, SS, Klein, S, Schierwagen, R, Raskopf, E, Strassburg, CP, Hiththetiya, K, Sauerbruch, T, Diehl, AM, and Trebicka, J. "Hedgehog-signaling and angiogenesis in cirrhotic and non-cirrhotic portal hypertension." 2014. Link to Item
  - Karaca, G, Xie, G, Swiderska-Syn, M, Michelotti, GA, Choi, SS, Burkly, LC, and Diehl, AM. "Absence of FN14 Ameliorates Acute Ethanol-Induced Steatohepatitis." October 2013. Link to Item
  - Pereira, TA, Syn, W-K, Choi, SS, Voieta, I, Resende, V, Souza, MM, Secor, WE, Vidigal, PV, Witek, RP, Andrade, ZA, Pereira, FE, Lambertucci, JR, and Diehl, AM. "Cholangiocyte proliferation and Osteopontin secretion is induced by Schistosoma mansoni egg antigens and correlates with fibrosis and portal hypertension in human and murine schistosomiasis." October 2013. Link to Item
  - Tucker, A, Michelotti, GA, Choi, SS, Xie, G, Karaca, G, Swiderska-Syn, M, Kruger, L, Machado, MV, Garman, KS, and Diehl, AM. "The Role of Pleiotrophin Signaling in the Hepatic Stem Cell Niche." October 2013. Link to Item
  - Xie, G, Karaca, G, Swiderska, M, Michelotti, GA, Krueger, L, Choi, SS, and Diehl, AM. "Notch Signaling Regulates Hepatic Stellate Cell Fate by Cross-Talking With Hedgehog Signaling." May 2013. Link to Item
  - Choi, SS, Jhaveri, R, Bradrick, S, Kuo, PC, and Syn, W-K. "Osteopontin regulates viral permissivity and replication in Huh7.5 cells infected with Hepatitis C Virus." October 2012. Link to Item
  - Chan, IS, Swiderska, M, Guy, CD, Chen, Y, Karaca, G, Xie, G, Choi, SS, Michelotti, GA, and Diehl, AM. "Hedgehog Inhibition Regulates the Stromal Microenvironment in Hepatocellular Carcinoma via Suppression of the Warburg Effect." May 2012. Link to Item
  - Choi, SS, Syn, W-K, Swiderska, M, Smith, MP, Diehl, AM, and Michelotti, GA. "Nr4a1 Nuclear Orphan Receptor is a Novel Regulator of Hepatic Fibrosis." May 2012. Link to Item
  - Liaskou, E, Zimmermann, H, Choi, SS, Qureshi, O, Stamataki, Z, Shaw, J, Curbishley, SM, Syn, W-K, and Adams, DH. "THREE PHENOTYPICALLY AND FUNCTIONALLY DISTINCT MONOCYTE SUBSETS AND THEIR ROLE IN HUMAN LIVER FIBROSIS." April 2012. Full Text Link to Item
  - Liaskou, E, Choi, SS, Qureshi, O, Curbishley, SM, Stamataki, Z, Syn, W-K, and Adams, DH. "CD14++CD16+monocyte/macrophages can induce fibrosis in human liver." December 2011. Link to Item
  - Chan, IS, Philips, GM, Zdanowicz, M, Teaberry, V, Karaca, G, Rangwala, F, Guy, CD, Moylan, CA, Venkatraman, T, Feuerlein, S, Syn, W-K, Jung, Y, Witek, RP, Michelotti, GA, Choi, SS, Merkle, EM, Lascola, C, and Diehl, AM. "HEDGEHOG PATHWAY INHIBITION BY GDC-0449 CAUSES REGRESSION OF HEPATOCELLULAR CARCINOMAS AND IMPROVES LIVER FIBROSIS IN MDR2-DEFICIENT MICE." October 2011. Link to Item
  - Chen, Y, Choi, SS, Michelotti, GA, Moylan, CA, Karaca, G, Zdanowicz, M, Xie, G, Kruger, L, and Diehl, AM. "TRANSITION OF QUIESCENT STELLATE CELLS INTO MYOFIBROBLASTS REQUIRES HEDGEHOG-MEDIATED INDUCTION OF GLYCOLYSIS." October 2011. Link to Item
  - Michelotti, GA, Choi, SS, Zdanowicz, M, Karaca, G, Premont, RT, and Diehl, AM. "ABROGATION OF CANONICAL HEDGEHOG ACTIVITY DECREASES HEPATIC FIBROSIS." October 2011. Link to Item
  - Philips, GM, Chan, IS, Choi, SS, Xie, G, Michelotti, GA, Zdanowicz, M, Teaberry, V, Rangwala, F, Guy, CD, Karaca, G, Venkatraman, T, Feuerlein, S, Moylan, CA, Syn, W-K, Jung, Y, Witek, RP, Merkle, EM, Lascola, C, and Diehl, AM. "HEDGEHOG PATHWAY INHIBITION INDUCES HCC TUMOR NECROSIS BY REPRESSING EXPRESSION OF ANGIOPOIETIN-2 AND ITS COGNATE RECEPTOR, TIE-2." October 2011. Link to Item
  - Philips, GM, Zdanowicz, M, Michelotti, GA, Choi, SS, Karaca, G, Chan, IS, and Diehl, AM. "HEDGEHOG PATHWAY ACTIVATION OCCURS IN PULMONARY MICROVASCULATURE DURING EXPERIMENTAL HEPATOPULMONARY SYNDROME (HPS)." October 2011. Link to Item
  - Xie, G, Choi, SS, Syn, W-K, Michelotti, GA, Zdanowicz, M, Karaca, G, Chen, Y, and Diehl, AM. "AUTOCRINE ACTIVATION OF THE HEDGEHOG PATHWAY DURING LIVER SINUSOIDAL ENDOTHELIAL CELL CAPILLARIZATION." October 2011. Link to Item
  - Moylan, CA, Dellinger, A, Pang, H, Suzuki, A, Tillmann, HL, Hampton, D, Chen, Y, Choi, SS, Hauser, MA, Abdelmalek, MF, and Diehl, AM. "Modest Alcohol Consumption Attenuates Expression of Fibrosis-Associated Genes in Patients With Non-Alcoholic Fatty Liver Disease (NAFLD)." May 2011. Link to Item
  - Choi, SS, Pereira, TA, Syn, W-K, Agboola, KM, Moylan, CA, Omenetti, A, Karaca, GF, Rangwala, F, Jhaveri, R, and Diehl, AM. "CO-CULTURE OF LIVER EPITHELIAL CELLS STABLY TRANSFECTED WITH HEPATITIS B VIRUS X PROTEIN PROMOTES MYOFIBROBLASTIC ACTIVATION AND ACCUMULATION VIA A HEDGEHOG-MEDIATED PROCESS IN RAT HEPATIC STELLATE CELLS." October 2010. Link to Item
  - Choi, SS, Syn, W-K, Smith, MP, Diehl, AM, and Michelotti, GA. "NR4A NUCLEAR ORPHAN RECEPTORS ARE NOVEL REGULATORS OF HEPATIC FIBROSIS." October 2010. Link to Item
  - Karaca, GF, Chen, Y, Syn, W-K, Ochoa, B, Choi, SS, Jakubowski, A, and Diehl, AM. "DEFECTIVE LIVER REGENERATION AFTER PARTIAL HEPATECTOMY IN MICE LACKING FIBROBLAST GROWTH FACTOR INDUCIBLE 14." October 2010. Link to Item
  - Moylan, CA, Abdelmalek, MF, Pang, H, Dellinger, A, Choi, SS, Omenetti, A, Chen, Y, Hampton, D, Syn, W-K, Suzuki, A, Tillmann, HL, Acharya, CR, Potti, A, Hauser, MA, and Diehl, AM. "SIGNALS FROM THE FIBROTIC LIVER IN PATIENTS WITH NAFLD MAY PROMOTE DIABETES AND OBESITY." October 2010. Link to Item
  - Moylan, CA, Choi, SS, Dellinger, A, Pang, H, Abdelmalek, MF, Hampton, D, Chen, Y, Omenetti, A, Suzuki, A, Tillmann, HL, Acharya, CR, Potti, A, Hauser, MA, and Diehl, AM. "CONSERVED GENE EXPRESSION PATTERNS IN MYOFIBROBLASTIC MURINE AND HUMAN HEPATIC STELLATE CELLS AND NAFLD PATIENTS WITH LIVER FIBROSIS COMPATIBLE WITH EPITHELIAL-TO-MESENCHYMAL LIKE TRANSITION." October 2010. Link to Item
  - Omenetti, A, Bass, LM, Anders, RA, Clemente, MG, Francis, H, Guy, CD, Choi, SS, Alpini, G, Schwarz, KB, Whitington, PF, and Diehl, AM. "HEDGEHOG PATHWAY DRIVES THE ACQUISITION OF MESENCHYMAL MARKERS IN DUCTULAR CELLS OF PATIENTS WITH BILIARY ATRESIA." October 2010. Link to Item
  - Omenetti, A, Yang, L, Gainetdinov, RR, Guy, CD, Choi, SS, Chen, W, Caron, MG, and Diehl, AM. "MYOFIBROBLAST-DERIVED TGF beta PROMOTES BILIARY TREE GROWTH DURING CHOLESTATIC LIVER INJURY BY SUPPRESSING ANGIOPOIETIN 1/TIE2/TRYPTOPHAN HYDROXYLASE 2 AXIS AND SEROTONIN SECRETION IN NEIGHBORING CHOLANGIOCYTES." October 2010. Link to Item
  - Pereira, TA, Syn, W-K, Voieta, I, Jiuyi, L, Choi, SS, Witek, RP, Agboola, KM, Karaca, GF, Antunes, CM, Secor, WE, Andrade, ZA, Lambertucci, JR, Pereira, FE, and Diehl, AM. "MACROPHAGE-DERIVED HEDGEHOG LIGANDS PROMOTES FIBROGENIC RESPONSES IN SCHISTOSOMIASIS MANSONI." October 2010. Link to Item
  - Syn, W-K, Choi, SS, Liaskou, E, Karaca, GF, Oo, YH, Pereira, TA, Bhattacharya, SD, Moylan, CA, Agboola, KM, Omenetti, A, Schroder, VT, Mi, Z, Guy, CD, Abdelmalek, MF, Potti, A, Kuo, PC, Michelotti, GA, Adams, DH, and Diehl, AM. "OSTEOPONTIN PROMOTES NONALCOHOLIC FATTY LIVER DISEASE PROGRESSION." October 2010. Link to Item
  - Choi, SS, Witek, RP, Syn, W-K, Omenetti, A, Karaca, GF, Jung, Y, Teaberry, VS, and Diehl, AM. "INTERACTION BETWEEN HEDGEHOG PATHWAY SIGNALING AND LEPTIN IN RAT HEPATIC STELLATE CELLS." October 2009. Link to Item
  - Pereira, TA, Witek, RP, Syn, W-K, Choi, SS, Jung, Y, Karaca, GF, Omenetti, A, Pereira, FE, and Diehl, AM. "HEDGEHOG SIGNALING, STELLATE CELL/ENDOTHELIAL CELL CROSS-TALK AND PROGRESSION OF VIRAL HEPATITIS." October 2009. Link to Item
  - Syn, W-K, Oo, YH, Witek, RP, Pereira, TA, Jung, Y, Karaca, GF, Omenetti, A, Choi, SS, Guy, CD, Fearing, C, Teaberry, VS, Pereira, FE, Adams, DH, and Diehl, AM. "HEDGEHOG-RELATED ACCUMULATION OF NKT CELLS PROMOTES FIBROGENESIS IN PROGRESSIVE NON ALCOHOLIC FATTY LIVER DISEASE." October 2009. Link to Item
  - Teaberry, VS, Karaca, GF, Witek, RP, Syn, W-K, Omenetti, A, Jung, Y, Choi, SS, and Diehl, AM. "NOVEL ROLE FOR HEDGEHOG PATHWAY ACTIVATION IN THE PATHOGENESIS OF PRIMARY SCLEROSING CHOLANGITIS." October 2009. Link to Item
  - Witek, RP, Pereira, TA, Syn, W-K, Jung, Y, Agboolo, KM, Choi, SS, and Diehl, AM. "TRANSIENT HEDGEHOG PATHWAY ACTIVATION AND ACCUMULATION OF HEDGEHOG-RESPONSIVE MYOFIBROBLASTS PRECEDE EXPANSION OF LIVER EPITHELIAL PROGENITORS AFTER ACUTE CARBON TETRACHLORIDE INJURY." October 2009. Link to Item
  - Choi, SS, Witek, RP, Omenetti, A, Yang, L, Syn, W-K, Jung, Y, Sicklick, JK, and Diehl, AM. "Sustained Activation of RAC1 Enhances Hedgehog-Mediated Epithelial-Mesenchymal Transition in Mice with Chronic Liver Injury." May 2009. Link to Item
  - Jung, Y, Witek, RP, Syn, W-K, Choi, SS, Omenetti, A, and Diehl, AM. "Specific Inhibition of Ikk beta in Hepatocytes Induces Proliferation of Liver Progenitors in Injured Livers." May 2009. Link to Item
  - Omenetti, A, Yang, L, Gainetdinov, RR, Choi, SS, Witek, RP, Jung, Y, Syn, W-K, Chen, W, Caron, MG, and Diehl, AM. "Myofibroblasts Promote the Growth of Biliary Tree During Cholestatic Liver Injury By Suppressing Tryptophan Hydroxylase 2 (TPH2) Expression and Serotonin Secretion in Neighboring Cholangiocytese." May 2009. Link to Item
  - Choi, SS, Omenetti, A, Witek, RP, Ren, X-R, Yang, L, Syn, W-K, Sicklick, JK, Jung, Y, Chen, W, and Diehl, AM. "SUSTAINED ACTIVATION OF RAC1 ENHANCES HEDGEHOG-MEDIATED EPITHELIAL-MESENCHYMAL TRANSITION IN CULTURED RAT HEPATIC STELLATE CELLS." October 2008. Link to Item
  - Moylan, CA, Choi, SS, Acharya, CR, Salter, K, Muir, AJ, Potti, A, and Diehl, AM. "GENE EXPRESSION PROFILES COUPLED WITH SIGNATURES OF ONCOGENIC PATHWAY DYSREGULATION PROVIDE A RATIONAL APPROACH TO DISSECTING THE MOLECULAR HETEROGENEITY OF HEPATOCELLULAR CARCINOMA." October 2008. Link to Item
  - Omenetti, A, Syn, W-K, Jung, Y, Witek, RP, Choi, SS, Gershwin, ME, and Diehl, AM. "PARACRINE HEDGEHOG SIGNALING BETWEEN CHOLANGIOCYTES AND MYOFIBROBLASTS PROMOTES NKT CELL MIGRATION TOWARDS BILIARY EPITHELIAL CELLS: A NOVEL MECHANISM FOR NKT CELL ACCUMULATION IN PRIMARY BILIARY CIRRHOSIS." October 2008. Link to Item
  - Syn, W-K, Witek, RP, Jung, Y, Choi, SS, Omenetti, A, and Diehl, AM. "HEDGEHOG ACTIVATES AND MODULATES HEPATIC INVARIANT NKT (INKT) RESPONSES." October 2008. Link to Item
  - Syn, W-K, Yang, L, Jung, Y, Witek, RP, Choi, SS, Omenetti, A, and Diehl, AM. "HEDGEHOG PATHWAY ACTIVATION PROMOTES HEPATIC FIBROSIS IN MICE WITH DIET-INDUCED NON-ALCOHOLIC STEATOHEPATITIS." October 2008. Link to Item
  - Witek, RP, Liu, R, Syn, W-K, Jung, Y, Omenetti, A, Yang, L, Choi, SS, Chen, W, and Diehl, AM. "EXOSOMES RELEASED BY HEPATIC STELLATE CELLS AND IMMATURE BILIARY EPITHELIAL CELLS CONTAIN BIOLOGICALLY-ACTIVE HEDGEHOG LIGANDS." October 2008. Link to Item
  - Choi, SS, Omenetti, A, Yang, L, Witek, RP, Brown, KD, Vazquez-Chantada, M, Huang, J, Jung, Y, Syn, W-K, Sicklick, JK, and Diehl, AM. "Culture activation of murine hepatic stellate cells involves hedgehog pathway activation and epithelial-to-mesenchymal transitions." April 2008. Link to Item
  - Omenetti, A, Porrello, A, Syn, W-K, Choi, SS, Jung, Y, Yang, L, Brown, KD, Witek, RP, Vandongen, H, and Diehl, AM. "Myofibroblast-derived soluble factors upregulate chemokine gene expression in neighboring cholangiocytes." April 2008. Link to Item
  - Witek, RP, Liu, R, Yang, L, Jung, Y, Brown, K, Omenetti, A, Vazquez-Chantada, M, Syn, W-K, Choi, SS, Huang, J, Chen, W, and Diehl, AM. "Liver-derived microparticles carry biologically-active Hedgehog morphogens, in blood and bile." April 2008. Link to Item
  - Yang, L, Jung, Y, Huang, J, Omenetti, A, Witek, RP, Choi, SS, Alpini, G, and Diehl, AM. "Glial fibrillary acidic protein(+) progenitors regenerate adult livers." April 2008. Link to Item
  - Omenetti, A, Qi, Y, Sicklick, JK, Choi, SS, Li, Y-X, and Diehl, AM. "Co-culture of hepatic stellate cells and cholangiocytes increases cell proliferation via autocrine/paracrine signaling." April 2006. Link to Item
  - Batavia, A, Hernandez-Perez, E, Bustamante, M, Dominguez-Rosales, JA, Sicklick, JK, Choi, SS, Ma, Q, Goldshmidt-Clermont, PJ, Dieh, AM, and Rojkind, M. "Oxidative stress mediates the transformation of rodent hepatic stellate cells to myoribroblasts in culture." March 6, 2006. Link to Item
  - Choi, SS, Huang, JW, Sicklick, JK, Ma, Q, Camp, JT, Goldschmidt-Clermont, PJ, and Diehl, AM. "Rac over-expression in activated hepatic stellate cells increases susceptibility to liver injury." October 2005. Link to Item
  - Sicklick, JK, Rojkind, M, Qi, Y, Chen, W, Bustamante, M, Choi, SS, Huang, JW, Camp, T, Torbenson, MS, Li, YX, and Diehl, AM. "Hedgehog signaling in hepatic stellate cells from adult mice and rats." October 2005. Link to Item

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