Current Appointments & Affiliations
Adjunct Assistant Professor of Medicine
·
2017 - Present
Medicine, Endocrinology, Metabolism, and Nutrition,
Medicine
Member of Sarah W. Stedman Nutrition and Metabolism Center
·
2005 - Present
Sarah Stedman Nutrition & Metabolism Center,
Duke Molecular Physiology Institute
Recent Publications
Statin therapy inhibits fatty acid synthase via dynamic protein modifications.
Journal Article Nat Commun · May 10, 2022 Statins are a class of drug widely prescribed for the prevention of cardiovascular disease, with pleiotropic cellular effects. Statins inhibit HMG-CoA reductase (HMGCR), which converts the metabolite HMG-CoA into mevalonate. Recent discoveries have shown H ... Full text Link to item CiteMuscle-Liver Trafficking of BCAA-Derived Nitrogen Underlies Obesity-Related Glycine Depletion.
Journal Article Cell Rep · November 10, 2020 Glycine levels are inversely associated with branched-chain amino acids (BCAAs) and cardiometabolic disease phenotypes, but biochemical mechanisms that explain these relationships remain uncharted. Metabolites and genes related to BCAA metabolism and nitro ... Full text Link to item CiteCord Blood Metabolomics: Association With Newborn Anthropometrics and C-Peptide Across Ancestries.
Journal Article J Clin Endocrinol Metab · October 1, 2019 CONTEXT: Newborn adiposity is associated with childhood obesity. Cord blood metabolomics is one approach that can be used to understand early-life contributors to adiposity and insulin resistance. OBJECTIVE: To determine the association of cord blood metab ... Full text Link to item CiteRecent Grants
Metabolic Regulators of Insulin Secretion and Insulin Resistance
ResearchCollaborator · Awarded by National Institutes of Health · 2013 - 2015NCI Metabolomics Assays
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2007 - 2009View All Grants
Education, Training & Certifications
University of London (United Kingdom) ·
1969
Ph.D.