Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., California Institute of Technology 1969
  • B.A., Dartmouth College 1964
• 

  Previous Appointments & Affiliations

  • Director of Graduate Studies in the Department of Chemistry, Chemistry, Trinity College of Arts & Sciences 2008 - 2011
  • Chair, Chemistry, Trinity College of Arts & Sciences 1995 - 1999
  • Adjunct Professor, Education, Trinity College of Arts & Sciences 1989 - 1992
  • Director, Graduate Studies (MAT), Chemistry, Trinity College of Arts & Sciences 1989 - 1991
  • Associate Professor with Tenure, Chemistry, Trinity College of Arts & Sciences 1976 - 1987
  • Assistant Professor, Chemistry, Trinity College of Arts & Sciences 1970 - 1976
• Research
• 

  Selected Grants

  • Research Experiences for Undergraduates in Chemistry awarded by  National Science Foundation 1997 - 2000
  • Strategies for Tetrodotoxin and Azadirachtin awarded by National Institutes of Health 1994 - 1998
  • Undergraduate Research Experiences in Chemistry at Duke University awarded by  National Science Foundation 1997 - 1998
  • Research Experiences for Undergraduates in Chemistry at Duke University awarded by  National Science Foundation 1994 - 1997
  • New Methodology for Glycoproteins awarded by National Institutes of Health 1992 - 1997
  • Research Experiences for Undergraduates in Chemistry at Duke University awarded by  National Science Foundation 1994 - 1996
  • A 400 MHZ NMR Spectrometer for Chemical Research awarded by  National Science Foundation 1995 - 1996
  • NSF Minority Fellowship awarded by  National Science Foundation 1995 - 1996
  • Undergraduate Research Experiences in Chemistry at Duke University awarded by  National Science Foundation 1994 - 1995
  • Synthesis of Some Optically Active Geisemium Alkaloids awarded by National Institutes of Health 1993 - 1995
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Baldwin, S. M., J. E. Bercaw, L. M. Henling, M. W. Day, and H. H. Brintzinger. “Cationic alkylaluminum-complexed zirconocene hydrides: NMR-spectroscopic identification, crystallographic structure determination, and interconversion with other zirconocene cations.” Journal of the American Chemical Society 133, no. 6 (2011): 1805–13. https://doi.org/10.1021/ja1050428.
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    • Baldwin, S. M., J. E. Bercaw, and H. H. Brintzinger. “Cationic alkylaluminum-complexed zirconocene hydrides as participants in olefin polymerization catalysis.” Journal of the American Chemical Society 132, no. 40 (October 13, 2010): 13969–71. https://doi.org/10.1021/ja105040r.
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    • Adler, M. J., and S. W. Baldwin. “Direct, regioselective synthesis of 2,2-dimethyl-2H-chromenes. Total syntheses of octandrenolone and precocenes I and II.” Tetrahedron Letters 50, no. 36 (September 9, 2009): 5075–79. https://doi.org/10.1016/j.tetlet.2009.06.090.
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    • Baldwin, S. M., J. E. Bereaw, and H. H. Brintzinger. “Alkylaluminum-complexed zirconocene hydrides: Identification of hydride-bridged species by NMR spectroscopy.” Journal of the American Chemical Society 130, no. 51 (December 24, 2008): 17423–33. https://doi.org/10.1021/ja8054723.
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    • Mao, Zhan, and Steven W. Baldwin. “New spirocyclic oxindole synthesis based on a hetero Claisen rearrangement.” Organic Letters 6, no. 14 (July 2004): 2425–28. https://doi.org/10.1021/ol0491888.
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    • Baldwin, Steven W., and Alan Long. “2-tert-butyl-3-methyl-2,3-dihydroimidazol- 4-one-N-oxide: a new nitrone-based chiral glycine equivalent.” Organic Letters 6, no. 10 (May 2004): 1653–56. https://doi.org/10.1021/ol049505a.
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    • DeGrado, T. R., S. W. Baldwin, S. Wang, M. D. Orr, R. P. Liao, H. S. Friedman, R. Reiman, D. T. Price, and R. E. Coleman. “Synthesis and evaluation of (18)F-labeled choline analogs as oncologic PET tracers.” J Nucl Med 42, no. 12 (December 2001): 1805–14.
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    • Long, A., and S. W. Baldwin. “Enantioselective syntheses of homophenylalanine derivatives via nitrone 1,3-dipolar cycloaddition reactions with styrenes.” Tetrahedron Letters 42, no. 32 (August 6, 2001): 5343–45. https://doi.org/10.1016/S0040-4039(01)00821-8.
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    • DeGrado, T. R., R. E. Coleman, S. Wang, S. W. Baldwin, M. D. Orr, H. S. Friedman, C. Robertson, and D. T. Price. “Synthesis and Evaluation of 18F-labeled Choline as an Oncologic PET Tracer.” Cancer Research 61 (2001): 110–17.
    • DeGrado, T. R., R. E. Coleman, S. Wang, S. W. Baldwin, M. D. Orr, C. N. Robertson, T. J. Polascik, and D. T. Price. “Synthesis and evaluation of 18F-labeled choline as an oncologic tracer for positron emission tomography: initial findings in prostate cancer.” Cancer Res 61, no. 1 (January 1, 2001): 110–17.
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    • Coleman, R., T. DeGrado, S. Wang, S. Baldwin, M. Orr, R. Reiman, and D. Price. “9:30-9:45. Preliminary Evaluation of F-18 Fluorocholine (FCH) as a PET Tumor Imaging Agent.” Clin Positron Imaging 3, no. 4 (July 2000): 147. https://doi.org/10.1016/s1095-0397(00)00059-5.
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    • Baldwin, S. W., P. Chen, N. Nikolic, and D. C. Weinseimer. “A solution to the cyclic aldol problem.” Organic Letters 2, no. 9 (May 2000): 1193–96. https://doi.org/10.1021/ol005525a.
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    • Baldwin, S. W., and J. Debenham. “Stereospecific Total Syntheses of Optically Pure (-)-Haemanthidine, (+)-Pretazettine, and (+)-Tazettine.” Org. Lett. 2 (2000): 99.
    • Baldwin, S. W., and J. S. Debenham. “Total syntheses of (-)-haemanthidine, (+)-pretazettine, and (+)-tazettine.” Organic Letters 2, no. 2 (January 2000): 99–102. https://doi.org/10.1021/ol9911472.
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    • Pullen, S. H., S. L. Martinez, A. L. Harris, A. Long, S. W. Baldwin, H. A. Staab, and J. D. Simon. “Comparison of the Photoinduced Electron Transfer Reaction in a Rigid Cyclophane with its Corresponding Bimolecular Donor/Acceptor Complex.” J. Phys. Chem. A. 103 (1999): 10220.
    • Baldwin, S. W., B. G. Young, and A. T. McPhail. “Preparation and evaluation of a cyclic acyl nitrone as a synthon for stereospecific α-amino acid synthesis.” Tetrahedron Letters 39, no. 38 (September 17, 1998): 6819–22. https://doi.org/10.1016/S0040-4039(98)01474-9.
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    • Baldwin, S. W., A. T. McPhail, and J. Aubé. “Studies Directed at the Synthesis of Optically Active Pretazettine via Intramolecular Nitrone/Alkene Cycloaddition Reactions.” Journal of Organic Chemistry 56, no. 23 (November 1, 1991): 6546–50. https://doi.org/10.1021/jo00023a019.
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    • Baldwin, S. W., P. Greenspan, C. Alaimo, and A. T. McPhail. “Diastereoselective diels-alder reactions between substituted 1,3-butadienes and n-α-methylbenzylmaleimide.” Tetrahedron Letters 32, no. 42 (October 14, 1991): 5877–80. https://doi.org/10.1016/S0040-4039(00)79415-9.
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    • Baldwin, S. W., and J. M. McIver. “Stereochemistry of the reactions of some "CH3-" nucleophiles with 2-(tetrahydrofur-2′-yl)-acetaldehyde.” Tetrahedron Letters 32, no. 17 (April 22, 1991): 1937–40. https://doi.org/10.1016/0040-4039(91)85006-Q.
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    • Baldwin, S. W., and S. C. Gedon. “Effect of Nitrogen Substitution on the Diastereoselection of Intramolecular Nitrone/Alkene Cycloadditions.” Synthetic Communications 21, no. 4 (February 1, 1991): 587–96. https://doi.org/10.1080/00397919108016788.
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    • Baldwin, S. W., and J. M. McIver. “Nucleophiles with 2-(Tetrahydrofur-2'-γl)-Acetaldehyde.” Tetrahedron Lett. 32, no. 17 (1991): 1937.
    • Baldwin, S. W., and S. C. Gedon. “Effect of Nitrogen Substitution on the Diastereoselection of Intramolecular Nitrone/Alkene Cycloadditions.” Syn. Commun. 41, no. 4 (1991): 587.
    • Aub, SW Baldwin RB McFadyen J., SW Baldwin RB McFadyen J. 233, and J. D. Wilson. “Diastereoselectivity in the Intramolecular Cycloaddition Reactions of Nitrones Derived from 5-Alkenals and Chiral Hydroxylamines.” Tetrahedron Lett. 32 (1991): 4431.
    • Baldwin, S. W., and J. Aubé. “Asymmetric synthesis with chiral hydroxylamines. Synthesis of optically pure 4-substituted azetidinones.” Tetrahedron Letters 28, no. 2 (January 1, 1987): 179–82. https://doi.org/10.1016/S0040-4039(00)95680-6.
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    • Baldwin, S. W., and J. M. Mclver. “Stereoselective Synthesis of (±)-methyl Nonactate.” Journal of Organic Chemistry 52, no. 2 (January 1, 1987): 320–22. https://doi.org/10.1021/jo00378a043.
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    • Baldwin, S. W., T. J. Mazzuckelli, and P. M. Gross. “Face selectivity in the [2+2] photoannelation of chiral 3(2h)-furanones with alkenes.” Tetrahedron Letters 27, no. 49 (January 1, 1986): 5975–78. https://doi.org/10.1016/S0040-4039(00)85376-9.
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    • Baldwin, S. W., G. F. Martin, and D. S. Nunn. “Total Synthesis of (+)-Elemol by Photoannelation.” Journal of Organic Chemistry 50, no. 26 (January 1, 1985): 5720–23. https://doi.org/10.1021/jo00350a055.
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    • Wilson, SW Baldwin J. D., J. Aub, and J. 233. “Regiochemistry in the Intramolecular Cycloadditions of Substituted 5-Alkenyl Nitrones.” J. Org. Chem. 50 (1985): 4432.
    • Baldwin, S. W., and H. R. Blomquist. “Facile synthesis of 2-substituted cyclopentenones.” Tetrahedron Letters 23, no. 38 (January 1, 1982): 3883–86. https://doi.org/10.1016/S0040-4039(00)87733-3.
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    • Baldwin, S. W., and H. R. Blomquist. “Cyclohexenones by the Barton Fragmentation of Tertiary Alcohols Derived from Furanone/Alkene Photoadducts.” Journal of the American Chemical Society 104, no. 18 (January 1, 1982): 4990–92. https://doi.org/10.1021/ja00382a061.
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    • Baldwin, S. W., and J. E. Fredericks. “Spiro[4.5]decanes by photoannelation. Total synthesis of (-)-acorenone.” Tetrahedron Letters 23, no. 12 (January 1, 1982): 1235–38. https://doi.org/10.1016/S0040-4039(00)87069-0.
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    • Baldwin, S. W., and M. T. Crimmins. “Total Synthesis of (−)-Sarracenin by Photoannelation.” Journal of the American Chemical Society 104, no. 4 (January 1, 1982): 1132–34. https://doi.org/10.1021/ja00368a054.
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    • Baldwin, S. W., and N. G. Landmesser. “Total synthesis of d,1-occidentalol by photoannelation.” Tetrahedron Letters 23, no. 43 (January 1, 1982): 4443–46. https://doi.org/10.1016/S0040-4039(00)85623-3.
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    • Baldwin, S. W. “Synthetic Aspects of [2 + 2] Cycloadditions of α,&#223-Unsaturated Carbonyl Compounds.” Organic Photochemistry 5 (1981).
    • Baldwin, S. W., and J. C. Tomesch. “Total Synthesis of dl-Cyclosativene by Cationic Olefinic and Acetylenic Cyclizations.” Journal of Organic Chemistry 45, no. 8 (January 1, 1980): 1455–62. https://doi.org/10.1021/jo01296a022.
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    • Baldwin, S. W., and J. M. Wilkinson. “Four-Carbon Photochemical Annelation of Alkenes with 2,2,6-Trimethyl-1,3-dioxolenone.” Journal of the American Chemical Society 102, no. 10 (January 1, 1980): 3634–35. https://doi.org/10.1021/ja00530a059.
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    • Baldwin, S. W., and T. Crimmins. “Synthesis of the Alleged Genipic Acid by Photoannelation.” Journal of the American Chemical Society 102, no. 3 (January 1, 1980): 1198–1200. https://doi.org/10.1021/ja00523a064.
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    • Baldwin, S. W., and J. M. Wilkinson. “Cyclohexenones by the photoannelation of alkenes with 2,2-dimethyl-3(2H)-furanone.” Tetrahedron Letters 20, no. 29 (January 1, 1979): 2657–60. https://doi.org/10.1016/S0040-4039(01)86378-4.
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    • Baldwin, S. W., and R. J. Doll. “Synthesis of the 2-aza-7-oxatricyclo[4.3.2.0^4,8]undecane nucleus of some gelsemium alkaloids.” Tetrahedron Letters 20, no. 35 (January 1, 1979): 3275–78. https://doi.org/10.1016/S0040-4039(01)95383-3.
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    • Baldwin, S. W., M. T. Crimmins, and V. I. Cheek. “A convenient preparation of α-methylene-d-valerolactones.” Synthesis (Germany) 1978, no. 3 (March 1, 1978): 210–11. https://doi.org/10.1055/s-1978-24708.
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    • Baldwin, S. W., M. T. Crimmins, and P. M. Gross. “A facile synthesis of δ-valerolactones by photoannelation.” Tetrahedron Letters 19, no. 44 (January 1, 1978): 4197–4200. https://doi.org/10.1016/S0040-4039(01)95180-9.
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    • Baldwin, S. W., and N. G. Landmesser. “Benzyl and Allyl Diazoacetate in One Carbon Ring Expansions of Ketones.” Synthetic Communications 8, no. 6 (January 1, 1978): 413–19. https://doi.org/10.1080/00397917808063567.
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    • Baldwin, S. W., P. W. Jeffs, and S. Natarajan. “Preparation of Norcocaine.” Synthetic Communications 7, no. 1 (January 1, 1977): 79–84. https://doi.org/10.1080/00397917709410059.
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    • Baldwin, S. W., and T. H. O’Neill. “Benzylic Bromination With Bromotrichloromethane.” Synthetic Communications 6, no. 2 (January 1, 1976): 109–12. https://doi.org/10.1080/00397917608072618.
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    • Baldwin, S. W., and S. A. Haut. “Reductive Deoxygenation of Esters with Trichlorosilane.” Journal of Organic Chemistry 40, no. 26 (December 1, 1975): 3885–87. https://doi.org/10.1021/jo00914a016.
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    • Baldwin, S. W., R. E. Gawley, R. J. Doll, and K. H. Leung. “Photoannelations with α-Formyl Ketones. Enol Specificity in the Reaction of Acyclic α-Formyl Ketones with Alkenes.” Journal of Organic Chemistry 40, no. 12 (June 1, 1975): 1865–67. https://doi.org/10.1021/jo00900a052.
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    • Baldwin, S. W., and J. C. Tomesch. “Model Studies for the Synthesis of Tetracyclic Sesquiterpenes.” Synthetic Commun. 5, no. 6 (1975): 441.
    • Baldwin, S. W., and J. C. Tomesch. “Stereospecific synthesis of d,l-cyclosativene. Alkyne capture of an homoallylic carbonium ion.” Tetrahedron Letters 16, no. 12 (January 1, 1975): 1055–58. https://doi.org/10.1016/S0040-4039(00)72643-8.
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    • Baldwin, S. W., and J. C. Tomesch. “Model Studies For The Synthesis Of Tetracyclic Sesquiterpenes.” Synthetic Communications 5, no. 6 (January 1, 1975): 445–50. https://doi.org/10.1080/00397917508065579.
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    • Baldwin, S. W., and R. E. Gawley. “Photoannelations with α-formyl ketones. A facile synthesis of the cis-9,10-dimethyldecalin ring system of the valerane sesquiterpenes.” Tetrahedron Letters 16, no. 46 (January 1, 1975): 3969–72. https://doi.org/10.1016/S0040-4039(00)91211-5.
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    • Baldwin, S. W., R. J. Doll, and S. A. Haut. “Selectivity in the Free-Radical Reduction of Lactones with Trichlorosilane.” Journal of Organic Chemistry 39, no. 16 (August 1, 1974): 2470–72. https://doi.org/10.1021/jo00930a053.
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    • Baldwin, S. W., and J. C. Tomesch. “Stereoselective Synthesis of 3-Exo-Substituted 2-endo-Acyl-5-norborene Derivatives.” Journal of Organic Chemistry 39, no. 16 (August 1, 1974): 2382–85. https://doi.org/10.1021/jo00930a011.
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    • Breslow, R., S. Baldwin, T. Flechtner, P. Kalicky, S. Liu, and W. Washburn. “Remote oxidation of steroids by photolysis of attached benzophenone groups.” Journal of the American Chemical Society 95, no. 10 (May 1973): 3251–62. https://doi.org/10.1021/ja00791a031.
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    • Baldwin, S. W., and E. H. Page. “Intramolecular keten cycloadditions in unconstrained systems.” Journal of the Chemical Society, Chemical Communications 0, no. 24 (December 1, 1972): 1337–38. https://doi.org/10.1039/C39720001337.
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    • Ireland, R. E., S. W. Baldwin, and S. C. Welch. “Experiments Directed toward the Total Synthesis of Terpenes. XVII. Development of Methods for the Synthesis of Pentacyclic Triterpenes Based on a Mechanistic Interpretation of the Stereochemical Outcome of the Friedel–Crafts Cyclialkylation Reaction.” Journal of the American Chemical Society 94, no. 6 (March 1, 1972): 2056–66. https://doi.org/10.1021/ja00761a044.
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    • Ireland, R. E., S. W. Baldwin, D. J. Dawson, M. I. Dawson, J. E. Dolfini, J. Newbould, W. S. Johnson, et al. “The Total Synthesis of an Unsymmetrical Pentacyclic Triterpene. DL-Germanicol.” Journal of the American Chemical Society 92, no. 19 (September 1, 1970): 5743–46. https://doi.org/10.1021/ja00722a041.
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    • Breslow, R., and S. W. Baldwin. “Conversion of Cholestanol to 12-Ketocholestanol and to Δ14- and Δ8(14)-Cholestenol by Remote Oxidation.” Journal of the American Chemical Society 92, no. 3 (February 1, 1970): 732–34. https://doi.org/10.1021/ja00706a068.
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    • Spencer, T. A., S. W. Baldwin, and K. K. Schmiegel. “Pyrolysis of 2-Acetoxy-2-(3-oxobutyl)cyclohexane-1,3-dione.” Journal of Organic Chemistry 30, no. 4 (April 1, 1965): 1294–96. https://doi.org/10.1021/jo01015a537.
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    • Spencer, T. A., M. D. Newton, and S. W. Baldwin. “Condensation of Diethyl Malonate with Methyl Vinyl Ketone.” Journal of Organic Chemistry 29, no. 4 (April 1, 1964): 787–89. https://doi.org/10.1021/jo01027a004.
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• Teaching & Mentoring
• 

  Recent Courses

  • CHEM 202D: Organic Chemistry II 2023
  • CHEM 201DL: Organic Chemistry I 2022
  • CHEM 202D: Organic Chemistry II 2022
  • CHEM 201DL: Organic Chemistry I 2021
  • CHEM 202D: Organic Chemistry II 2021
  • CHEM 393: Research Independent Study 2021
  • CHEM 394: Research Independent Study 2021
  • CHEM 493: Research Independent Study 2021
  • CHEM 494: Research Independent Study 2021
  • CHEM 532: Organic Reactions 2021
• Scholarly, Clinical, & Service Activities
• 

  Presentations & Appearances

  • Application of Z-Locked Glycine-Derived Nitrones to the Synthesis of th Artificial Sweetener Monatin. November 1, 2008  2008
• 

  Service to the Profession

  • Reviewer. January 12, 2008  2008

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