Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Fellow in Cardiology, Medicine, Duke University 2000 - 2004
  • Medical Resident, Medicine, Duke University 1997 - 2000
  • M.D., New York University 1997
• 

  Previous Appointments & Affiliations

  • Associate Professor of Medicine, Medicine, Cardiology, Medicine 2021 - 2022
  • Associate Professor of Medicine, Medicine, Cardiology, Medicine 2018 - 2020
  • Associate Professor of Medicine, Medicine, Cardiology, Medicine 2016 - 2018
  • Assistant Professor of Medicine, Medicine, Cardiology, Medicine 2008 - 2016
  • Medical Instructor in the Department of Medicine, Medicine, Cardiology, Medicine 2004 - 2008
• Research
• 

  Selected Grants

  • Anti-Atherogenic Mechanisms of Drebrin awarded by National Institutes of Health 2019 - 2023
  • Role of Debrin in Vascular Smooth Muscle Transdifferentiation awarded by  American Heart Association 2019
  • Role of Drebrin in Atherosclerosis awarded by National Institutes of Health 2014 - 2019
  • Role of Drebrin in Vascular Smooth Muscle Remodeling awarded by National Institutes of Health 2013 - 2018
  • The role of STIM1 in cardiac and skeletal muscle function awarded by National Institutes of Health 2009 - 2014
  • Role of Homer Proteins in Calcium Signaling in Muscle awarded by National Institutes of Health 2005 - 2011
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Wu, Jiao-Hui, Lisheng Zhang, Igor Nepliouev, Leigh Brian, Taiqin Huang, Kamie P. Snow, Brandon M. Schickling, et al. “Drebrin attenuates atherosclerosis by limiting smooth muscle cell transdifferentiation.” Cardiovasc Res 118, no. 3 (February 21, 2022): 772–84. https://doi.org/10.1093/cvr/cvab156.
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    • Karnam, Shruthi, Rupalatha Maddala, Jonathan A. Stiber, and Ponugoti V. Rao. “Drebrin, an actin-binding protein, is required for lens morphogenesis and growth.” Dev Dyn 250, no. 11 (November 2021): 1600–1617. https://doi.org/10.1002/dvdy.353.
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    • Urak, Kevin T., Giselle N. Blanco, Shambhavi Shubham, Li-Hsien Lin, Justin P. Dassie, William H. Thiel, Yani Chen, et al. “RNA inhibitors of nuclear proteins responsible for multiple organ dysfunction syndrome.” Nat Commun 10, no. 1 (January 10, 2019): 116. https://doi.org/10.1038/s41467-018-08030-y.
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    • Mourad, Ahmad, Jonathan A. Stiber, John R. Perfect, and Melissa D. Johnson. “Real-world implications of QT prolongation in patients receiving voriconazole and amiodarone.” J Antimicrob Chemother 74, no. 1 (January 1, 2019): 228–33. https://doi.org/10.1093/jac/dky392.
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    • Zhang, Lisheng, Jiao-Hui Wu, Tai-Qin Huang, Igor Nepliouev, Leigh Brian, Zhushan Zhang, Virginia Wertman, et al. “Drebrin regulates angiotensin II-induced aortic remodelling.” Cardiovasc Res 114, no. 13 (November 1, 2018): 1806–15. https://doi.org/10.1093/cvr/cvy151.
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    • Jean-Charles, Pierre-Yves, Jiao-Hui Wu, Lisheng Zhang, Suneet Kaur, Igor Nepliouev, Jonathan A. Stiber, Leigh Brian, et al. “USP20 (Ubiquitin-Specific Protease 20) Inhibits TNF (Tumor Necrosis Factor)-Triggered Smooth Muscle Cell Inflammation and Attenuates Atherosclerosis.” Arterioscler Thromb Vasc Biol 38, no. 10 (October 2018): 2295–2305. https://doi.org/10.1161/ATVBAHA.118.311071.
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    • Jean-Charles, Pierre-Yves, Samuel Mon-Wei Yu, Dennis Abraham, Reddy Peera Kommaddi, Lan Mao, Ryan T. Strachan, Zhu-Shan Zhang, et al. “Mdm2 regulates cardiac contractility by inhibiting GRK2-mediated desensitization of β-adrenergic receptor signaling.” Jci Insight 2, no. 17 (September 7, 2017). https://doi.org/10.1172/jci.insight.95998.
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    • Jackson, Larry R., Bharath Rathakrishnan, Kristen Campbell, Kevin L. Thomas, Jonathan P. Piccini, Tristram Bahnson, Jonathan A. Stiber, and James P. Daubert. “Sinus Node Dysfunction and Atrial Fibrillation: A Reversible Phenomenon?” Pacing Clin Electrophysiol 40, no. 4 (April 2017): 442–50. https://doi.org/10.1111/pace.13030.
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    • Zhang, Zhushan, Tai-Qin Huang, Igor Nepliouev, Hengtao Zhang, Adam S. Barnett, Paul B. Rosenberg, Sai-Hong I. Ou, and Jonathan A. Stiber. “Crizotinib Inhibits Hyperpolarization-activated Cyclic Nucleotide-Gated Channel 4 Activity.” Cardiooncology 3 (2017). https://doi.org/10.1186/s40959-017-0020-z.
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    • Stiber, Jonathan A., Jiao-Hui Wu, Lisheng Zhang, Igor Nepliouev, Zhu-Shan Zhang, Victoria G. Bryson, Leigh Brian, et al. “The Actin-Binding Protein Drebrin Inhibits Neointimal Hyperplasia.” Arterioscler Thromb Vasc Biol 36, no. 5 (May 2016): 984–93. https://doi.org/10.1161/ATVBAHA.115.306140.
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    • Ou, Sai-Hong Ignatius, Wilson P. Tong, Michele Azada, Christina Siwak-Tapp, Joni Dy, and Jonathan A. Stiber. “Heart rate decrease during crizotinib treatment and potential correlation to clinical response.” Cancer 119, no. 11 (June 1, 2013): 1969–75. https://doi.org/10.1002/cncr.28040.
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    • Stiber, Jonathan A., Youlan Tang, TianYu Li, and Paul B. Rosenberg. “Cytoskeletal regulation of TRPC channels in the cardiorenal system.” Curr Hypertens Rep 14, no. 6 (December 2012): 492–97. https://doi.org/10.1007/s11906-012-0313-4.
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    • Seth, Malini, Tianyu Li, Victoria Graham, Jarrett Burch, Elizabeth Finch, Jonathan A. Stiber, and Paul B. Rosenberg. “Dynamic regulation of sarcoplasmic reticulum Ca(2+) stores by stromal interaction molecule 1 and sarcolipin during muscle differentiation.” Dev Dyn 241, no. 4 (April 2012): 639–47. https://doi.org/10.1002/dvdy.23760.
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    • Ou, Sai-Hong Ignatius, Michele Azada, Joni Dy, and Jonathan A. Stiber. “Asymptomatic profound sinus bradycardia (heart rate ≤45) in non-small cell lung cancer patients treated with crizotinib.” J Thorac Oncol 6, no. 12 (December 2011): 2135–37. https://doi.org/10.1097/JTO.0b013e3182307e06.
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    • Stiber, Jonathan A., and Paul B. Rosenberg. “The role of store-operated calcium influx in skeletal muscle signaling.” Cell Calcium 49, no. 5 (May 2011): 341–49. https://doi.org/10.1016/j.ceca.2010.11.012.
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    • Nepliouev, Igor, Zhu-Shan Zhang, and Jonathan A. Stiber. “Effect of oxidative stress on homer scaffolding proteins.” Plos One 6, no. 10 (2011): e26128. https://doi.org/10.1371/journal.pone.0026128.
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    • Seth, Malini, Zhu-Shan Zhang, Lan Mao, Victoria Graham, Jarrett Burch, Jonathan Stiber, Leonidas Tsiokas, et al. “TRPC1 channels are critical for hypertrophic signaling in the heart.” Circ Res 105, no. 10 (November 6, 2009): 1023–30. https://doi.org/10.1161/CIRCRESAHA.109.206581.
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    • Stiber, Jonathan A., Malini Seth, and Paul B. Rosenberg. “Mechanosensitive channels in striated muscle and the cardiovascular system: not quite a stretch anymore.” J Cardiovasc Pharmacol 54, no. 2 (August 2009): 116–22. https://doi.org/10.1097/FJC.0b013e3181aa233f.
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    • Stiber, Jonathan, April Hawkins, Zhu-Shan Zhang, Sunny Wang, Jarrett Burch, Victoria Graham, Cary C. Ward, et al. “STIM1 signalling controls store-operated calcium entry required for development and contractile function in skeletal muscle.” Nat Cell Biol 10, no. 6 (June 2008): 688–97. https://doi.org/10.1038/ncb1731.
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    • Stiber, Jonathan A., Zhu-Shan Zhang, Jarrett Burch, Jerry P. Eu, Sarah Zhang, George A. Truskey, Malini Seth, et al. “Mice lacking Homer 1 exhibit a skeletal myopathy characterized by abnormal transient receptor potential channel activity.” Mol Cell Biol 28, no. 8 (April 2008): 2637–47. https://doi.org/10.1128/MCB.01601-07.
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    • Rajagopal, Keshava, Erin J. Whalen, Jonathan D. Violin, Jonathan A. Stiber, Paul B. Rosenberg, Richard T. Premont, Thomas M. Coffman, Howard A. Rockman, and Robert J. Lefkowitz. “Beta-arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes.” Proc Natl Acad Sci U S A 103, no. 44 (October 31, 2006): 16284–89. https://doi.org/10.1073/pnas.0607583103.
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    • Du, Wanglei, Timothy J. McMahon, Zhu-Shan Zhang, Jonathan A. Stiber, Gerhard Meissner, and Jerry P. Eu. “Excitation-contraction coupling in airway smooth muscle.” J Biol Chem 281, no. 40 (October 6, 2006): 30143–51. https://doi.org/10.1074/jbc.M606541200.
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    • Stiber, Jonathan A., Niloufar Tabatabaei, April F. Hawkins, Thomas Hawke, Paul F. Worley, R Sanders Williams, and Paul Rosenberg. “Homer modulates NFAT-dependent signaling during muscle differentiation.” Dev Biol 287, no. 2 (November 15, 2005): 213–24. https://doi.org/10.1016/j.ydbio.2005.06.030.
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    • Tian, Xiaoyu, Jianxin Guo, Fenmei Yao, De-Ping Yang, and Alexandros Makriyannis. “The Conformation, Location, and Dynamic Properties of the Endocannabinoid Ligand Anandamide in a Membrane Bilayer.” Journal of Biological Chemistry 280, no. 33 (August 2005): 29788–95. https://doi.org/10.1074/jbc.m502925200.
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    • Du, Wanglei, Jonathan A. Stiber, Paul B. Rosenberg, Gerhard Meissner, and Jerry P. Eu. “Ryanodine receptors in muscarinic receptor-mediated bronchoconstriction.” J Biol Chem 280, no. 28 (July 15, 2005): 26287–94. https://doi.org/10.1074/jbc.M502905200.
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    • Rosenberg, Paul, April Hawkins, Jonathan Stiber, John M. Shelton, Kelley Hutcheson, Rhonda Bassel-Duby, Dong Min Shin, Zhen Yan, and R Sanders Williams. “TRPC3 channels confer cellular memory of recent neuromuscular activity.” Proc Natl Acad Sci U S A 101, no. 25 (June 22, 2004): 9387–92. https://doi.org/10.1073/pnas.0308179101.
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    • Unger, E. F., L. Goncalves, S. E. Epstein, E. Y. Chew, C. B. Trapnell, R. O. Cannon, and A. A. Quyyumi. “Effects of a single intracoronary injection of basic fibroblast growth factor in stable angina pectoris.” Am J Cardiol 85, no. 12 (June 15, 2000): 1414–19. https://doi.org/10.1016/s0002-9149(00)00787-6.
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    • Rajanayagam, M. A., M. Shou, V. Thirumurti, D. F. Lazarous, A. A. Quyyumi, L. Goncalves, J. Stiber, S. E. Epstein, and E. F. Unger. “Intracoronary basic fibroblast growth factor enhances myocardial collateral perfusion in dogs.” J Am Coll Cardiol 35, no. 2 (February 2000): 519–26. https://doi.org/10.1016/s0735-1097(99)00550-1.
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    • Lazarous, D. F., M. Shou, J. A. Stiber, E. Hodge, V. Thirumurti, L. Gonçalves, and E. F. Unger. “Adenoviral-mediated gene transfer induces sustained pericardial VEGF expression in dogs: effect on myocardial angiogenesis.” Cardiovasc Res 44, no. 2 (November 1999): 294–302. https://doi.org/10.1016/s0008-6363(99)00203-5.
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    • Lazarous, D. F., M. Shou, J. A. Stiber, D. M. Dadhania, V. Thirumurti, E. Hodge, and E. F. Unger. “Pharmacodynamics of basic fibroblast growth factor: route of administration determines myocardial and systemic distribution.” Cardiovasc Res 36, no. 1 (October 1997): 78–85. https://doi.org/10.1016/s0008-6363(97)00142-9.
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    • Shou, M., V. Thirumurti, S. Rajanayagam, D. F. Lazarous, E. Hodge, J. A. Stiber, M. Pettiford, E. Elliott, S. M. Shah, and E. F. Unger. “Effect of basic fibroblast growth factor on myocardial angiogenesis in dogs with mature collateral vessels.” J Am Coll Cardiol 29, no. 5 (April 1997): 1102–6. https://doi.org/10.1016/s0735-1097(97)00014-4.
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    • Lazarous, D. F., M. Shou, M. Scheinowitz, E. Hodge, V. Thirumurti, A. N. Kitsiou, J. A. Stiber, et al. “Comparative effects of basic fibroblast growth factor and vascular endothelial growth factor on coronary collateral development and the arterial response to injury.” Circulation 94, no. 5 (September 1, 1996): 1074–82. https://doi.org/10.1161/01.cir.94.5.1074.
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    • Lazarous, D. F., M. Scheinowitz, M. Shou, E. Hodge, S. Rajanayagam, S. Hunsberger, W. G. Robison, J. A. Stiber, R. Correa, and S. E. Epstein. “Effects of chronic systemic administration of basic fibroblast growth factor on collateral development in the canine heart.” Circulation 91, no. 1 (January 1, 1995): 145–53. https://doi.org/10.1161/01.cir.91.1.145.
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  • Book Sections

    • Stiber, J. A., and P. B. Rosenberg. “Skeletal muscle store-operated Ca²⁺ entry and STIM/Orai signaling in skeletal muscle.” In Store-Operated Ca2+ Entry (SOCE) Pathways: Emerging Signaling Concepts in Human (Patho)Physiology, 9783709109625:435–47, 2013. https://doi.org/10.1007/978-3-7091-0962-5_27.
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  • Conference Papers

    • Karnam, Shruthi, Rupalatha Maddala, Jonathan Andrew Stiber, and Ponugoti Vasantha Rao. “Actin-binding protein, Drebrin, is required for mouse lens morphogenesis and growth.” In Investigative Ophthalmology & Visual Science, Vol. 61, 2020.
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    • Zhang, Lisheng, Jiao-Hui Wu, Tai-Qin Huang, Igor Nepliouev, Leigh Brian, Zhushan Zhang, Nathan P. Rudemiller, Steven D. Crowley, Neil J. Freedman, and Jonathan A. Stiber. “Angiotensin II-Induced Aortic Inflammation and Remodeling Are Mitigated by the Actin-Binding Protein Drebrin.” In Circulation, Vol. 136. LIPPINCOTT WILLIAMS & WILKINS, 2017.
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    • Zhang, Hengtao, Albert Y. Sun, Jong J. Kim, Victoria Graham, Elizabeth A. Finch, Igor Nepliouev, Guiling Zhao, et al. “STIM1-Ca2+ signaling modulates automaticity of the mouse sinoatrial node.” In Proc Natl Acad Sci U S A, 112:E5618–27, 2015. https://doi.org/10.1073/pnas.1503847112.
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    • Black-Maier, Eric W., Jiao-Hui Wu, Alexander C. Fanaroff, Padmastuti Akella, Lisheng Zhang, Leigh Brian, Jonathan A. Stiber, et al. “The Dual RhoGEF Kalirin Reduces Atherosclerosis Through Endothelial Cell-Specific Mechanisms.” In Circulation, Vol. 128. LIPPINCOTT WILLIAMS & WILKINS, 2013.
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    • Stiber, Jonathan A., Lisheng Zhang, Igor Nepliouev, Zhu-Shan Zhang, Jiao-Hui Wu, Paul B. Rosenberg, and Neil J. Freedman. “The Actin-Binding Protein Drebrin Reduces TRP Channel Activity and Neointimal Hyperplasia.” In Circulation, Vol. 126. LIPPINCOTT WILLIAMS & WILKINS, 2012.
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    • Stiber, J. A., J. P. Eu, M. Seth, N. Tabatabaei, A. F. Hawkins, N. Yamaguchi, G. Meissner, R. S. Williams, and P. B. Rosenberg. “Homer 1 loss of function results in a myopathy due to a defect in transient receptor potential channel activation.” In Circulation, 112:U87–U87. LIPPINCOTT WILLIAMS & WILKINS, 2005.
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    • Lazarous, D. F., M. Shou, J. A. Stiber, D. Dadhania, V. Thirumurti, E. Hodge, and E. F. Unger. “Pharmacodynamics of basic fibroblast growth factor: Effect of route of administration on regional distribution.” In Journal of the American College of Cardiology, 29:95946–95946. ELSEVIER SCIENCE INC, 1997.
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    • Lazarous, D. F., M. Shou, J. A. Stiber, V. Thirumurti, E. Hodge, and E. F. Unger. “Adenoviral-mediated gene therapy induces sustained intrapericardial vascular endothelial growth factor expression in dogs: Effect on myocardial angiogenesis.” In Journal of the American College of Cardiology, 29:41148–41148. ELSEVIER SCIENCE INC, 1997.
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    • Shou, M., D. F. Lazarous, J. A. Stiber, V. Thirumurti, E. Hodge, and E. F. Unger. “The pericardium as a repository for an angiogenic growth factor: Effect of intrapericardial basic fibroblast growth factor on myocardial collateral development.” In Journal of the American College of Cardiology, 29:61116–61116. ELSEVIER SCIENCE INC, 1997.
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