Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Fellow in Cardiology, Medicine, Duke University 2000 - 2004
  • Medical Resident, Medicine, Duke University 1997 - 2000
  • M.D., New York University 1997
• 

  Duke Appointment History

  • Associate Professor of Medicine, Medicine, Cardiology, Medicine 2016 - 2018
  • Assistant Professor of Medicine, Medicine, Cardiology, Medicine 2008 - 2016
  • Medical Instructor in the Department of Medicine, Medicine, Cardiology, Medicine 2004 - 2008
• Research
• 

  Selected Grants

  • Role of Drebrin in Atherosclerosis awarded by National Institutes of Health 2014 - 2019
  • Role of Drebrin in Vascular Smooth Muscle Remodeling awarded by National Institutes of Health 2013 - 2018
  • The role of STIM1 in cardiac and skeletal muscle function awarded by National Institutes of Health 2009 - 2014
  • Role of Homer Proteins in Calcium Signaling in Muscle awarded by National Institutes of Health 2005 - 2011
• Publications & Artistic Works
• 

  Selected Publications

  • Book Sections

    • Stiber, JA, and Rosenberg, PB. "Skeletal muscle store-operated Ca²⁺ entry and STIM/Orai signaling in skeletal muscle." In Store-operated Ca2+ entry (SOCE) pathways: Emerging signaling concepts in human (patho)physiology, 435-447. November 1, 2013.  Full Text

  • Conference Papers

    • Zhang, H, Sun, AY, Kim, JJ, Graham, V, Finch, EA, Nepliouev, I, Zhao, G, Li, T, Lederer, WJ, Stiber, JA, Pitt, GS, Bursac, N, and Rosenberg, PB. "STIM1-Ca2+ signaling modulates automaticity of the mouse sinoatrial node." October 2015.  Full Text
    • Black-Maier, EW, Wu, J-H, Fanaroff, AC, Akella, P, Zhang, L, Brian, L, Stiber, JA, Peppel, K, Eipper, BA, Mains, R, and Freedman, NJ. "The Dual RhoGEF Kalirin Reduces Atherosclerosis Through Endothelial Cell-Specific Mechanisms." November 26, 2013.  Link to Item
    • Stiber, JA, Zhang, L, Nepliouev, I, Zhang, Z-S, Wu, J-H, Rosenberg, PB, and Freedman, NJ. "The Actin-Binding Protein Drebrin Reduces TRP Channel Activity and Neointimal Hyperplasia." November 20, 2012.  Link to Item
    • Stiber, JA, Eu, JP, Seth, M, Tabatabaei, N, Hawkins, AF, Yamaguchi, N, Meissner, G, Williams, RS, and Rosenberg, PB. "Homer 1 loss of function results in a myopathy due to a defect in transient receptor potential channel activation." October 25, 2005.  Link to Item
    • Lazarous, DF, Shou, M, Stiber, JA, Dadhania, D, Thirumurti, V, Hodge, E, and Unger, EF. "Pharmacodynamics of basic fibroblast growth factor: Effect of route of administration on regional distribution." February 1997.  Link to Item
    • Lazarous, DF, Shou, M, Stiber, JA, Thirumurti, V, Hodge, E, and Unger, EF. "Adenoviral-mediated gene therapy induces sustained intrapericardial vascular endothelial growth factor expression in dogs: Effect on myocardial angiogenesis." February 1997.  Link to Item
    • Shou, M, Lazarous, DF, Stiber, JA, Thirumurti, V, Hodge, E, and Unger, EF. "The pericardium as a repository for an angiogenic growth factor: Effect of intrapericardial basic fibroblast growth factor on myocardial collateral development." February 1997.  Link to Item

  • Journal Articles

    • Jean-Charles, P-Y, Yu, SM-W, Abraham, D, Kommaddi, RP, Mao, L, Strachan, RT, Zhang, Z-S, Bowles, DE, Brian, L, Stiber, JA, Jones, SN, Koch, WJ, Rockman, HA, and Shenoy, SK. "Mdm2 regulates cardiac contractility by inhibiting GRK2-mediated desensitization of β-adrenergic receptor signaling." JCI insight 2, no. 17 (September 7, 2017).  Full Text
    • Jackson, LR, Rathakrishnan, B, Campbell, K, Thomas, KL, Piccini, JP, Bahnson, T, Stiber, JA, and Daubert, JP. "Sinus Node Dysfunction and Atrial Fibrillation: A Reversible Phenomenon?." Pacing and clinical electrophysiology : PACE 40, no. 4 (April 2017): 442-450. (Review)  Full Text
    • Zhang, Z, Huang, T-Q, Nepliouev, I, Zhang, H, Barnett, AS, Rosenberg, PB, Ou, S-HI, and Stiber, JA. "Crizotinib Inhibits Hyperpolarization-activated Cyclic Nucleotide-Gated Channel 4 Activity." Cardio-oncology (London, England) 3 (January 19, 2017).  Full Text
    • Stiber, JA, Wu, J-H, Zhang, L, Nepliouev, I, Zhang, Z-S, Bryson, VG, Brian, L, Bentley, RC, Gordon-Weeks, PR, Rosenberg, PB, and Freedman, NJ. "The Actin-Binding Protein Drebrin Inhibits Neointimal Hyperplasia." Arteriosclerosis, thrombosis, and vascular biology 36, no. 5 (May 2016): 984-993.  Full Text
    • Ou, S-HI, Tong, WP, Azada, M, Siwak-Tapp, C, Dy, J, and Stiber, JA. "Heart rate decrease during crizotinib treatment and potential correlation to clinical response." Cancer 119, no. 11 (June 1, 2013): 1969-1975.  Full Text  Link to Item
    • Ou, S-HI, Tong, WP, Azada, M, Siwak-Tapp, C, Dy, J, and Stiber, JA. "Heart rate decrease during crizotinib treatment and potential correlation to clinical response." Cancer 119, no. 11 (2013): 1969-1975.  Full Text
    • Stiber, JA, Tang, Y, Li, T, and Rosenberg, PB. "Cytoskeletal regulation of TRPC channels in the cardiorenal system." Curr Hypertens Rep 14, no. 6 (December 2012): 492-497. (Review)  Full Text  Link to Item
    • Seth, M, Li, T, Graham, V, Burch, J, Finch, E, Stiber, JA, and Rosenberg, PB. "Dynamic regulation of sarcoplasmic reticulum Ca(2+) stores by stromal interaction molecule 1 and sarcolipin during muscle differentiation." Dev Dyn 241, no. 4 (April 2012): 639-647.  Full Text  Link to Item
    • Ou, S-HI, Azada, M, Dy, J, and Stiber, JA. "Asymptomatic profound sinus bradycardia (heart rate ≤45) in non-small cell lung cancer patients treated with crizotinib." J Thorac Oncol 6, no. 12 (December 2011): 2135-2137.  Full Text  Link to Item
    • Stiber, JA, and Rosenberg, PB. "The role of store-operated calcium influx in skeletal muscle signaling." Cell Calcium 49, no. 5 (May 2011): 341-349. (Review)  Full Text  Link to Item
    • Nepliouev, I, Zhang, Z-S, and Stiber, JA. "Effect of oxidative stress on homer scaffolding proteins." PLoS One 6, no. 10 (2011): e26128-.  Full Text  Link to Item
    • Seth, M, Zhang, Z-S, Mao, L, Graham, V, Burch, J, Stiber, J, Tsiokas, L, Winn, M, Abramowitz, J, Rockman, HA, Birnbaumer, L, and Rosenberg, P. "TRPC1 channels are critical for hypertrophic signaling in the heart." Circ Res 105, no. 10 (November 6, 2009): 1023-1030.  Full Text  Link to Item
    • Stiber, JA, Seth, M, and Rosenberg, PB. "Mechanosensitive channels in striated muscle and the cardiovascular system: not quite a stretch anymore." J Cardiovasc Pharmacol 54, no. 2 (August 2009): 116-122. (Review)  Full Text  Link to Item
    • Stiber, J, Hawkins, A, Zhang, Z-S, Wang, S, Burch, J, Graham, V, Ward, CC, Seth, M, Finch, E, Malouf, N, Williams, RS, Eu, JP, and Rosenberg, P. "STIM1 signalling controls store-operated calcium entry required for development and contractile function in skeletal muscle." Nat Cell Biol 10, no. 6 (June 2008): 688-697.  Full Text  Link to Item
    • Stiber, JA, Zhang, Z-S, Burch, J, Eu, JP, Zhang, S, Truskey, GA, Seth, M, Yamaguchi, N, Meissner, G, Shah, R, Worley, PF, Williams, RS, and Rosenberg, PB. "Mice lacking Homer 1 exhibit a skeletal myopathy characterized by abnormal transient receptor potential channel activity." Mol Cell Biol 28, no. 8 (April 2008): 2637-2647.  Full Text  Link to Item
    • Rajagopal, K, Whalen, EJ, Violin, JD, Stiber, JA, Rosenberg, PB, Premont, RT, Coffman, TM, Rockman, HA, and Lefkowitz, RJ. "Beta-arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes." Proc Natl Acad Sci U S A 103, no. 44 (October 31, 2006): 16284-16289.  Full Text  Link to Item
    • Du, W, McMahon, TJ, Zhang, Z-S, Stiber, JA, Meissner, G, and Eu, JP. "Excitation-contraction coupling in airway smooth muscle." J Biol Chem 281, no. 40 (October 6, 2006): 30143-30151.  Full Text  Link to Item
    • Stiber, JA, Tabatabaei, N, Hawkins, AF, Hawke, T, Worley, PF, Williams, RS, and Rosenberg, P. "Homer modulates NFAT-dependent signaling during muscle differentiation." Dev Biol 287, no. 2 (November 15, 2005): 213-224.  Full Text  Link to Item
    • Du, W, Stiber, JA, Rosenberg, PB, Meissner, G, and Eu, JP. "Ryanodine receptors in muscarinic receptor-mediated bronchoconstriction." J Biol Chem 280, no. 28 (July 15, 2005): 26287-26294.  Full Text  Link to Item
    • Du, WL, Stiber, JA, Rosenberg, PB, Meissner, G, and Eu, JP. "Ryanodine receptors in muscarinic receptor-mediated bronchoconstriction." JOURNAL OF BIOLOGICAL CHEMISTRY 280, no. 28 (July 15, 2005): 26287-26294.  Full Text  Link to Item
    • Rosenberg, P, Hawkins, A, Stiber, J, Shelton, JM, Hutcheson, K, Bassel-Duby, R, Shin, DM, Yan, Z, and Williams, RS. "TRPC3 channels confer cellular memory of recent neuromuscular activity." Proc Natl Acad Sci U S A 101, no. 25 (June 22, 2004): 9387-9392.  Full Text  Link to Item
    • Rajanayagam, MAS, Shou, M, Thirumurti, V, Lazarous, DF, Quyyumi, AA, Goncalves, L, Stiber, J, Epstein, SE, and Unger, EF. "Intracoronary basic fibroblast growth factor enhances myocardial collateral perfusion in dogs." Journal of the American College of Cardiology 35, no. 2 (2000): 519-526.  Full Text
    • Unger, EF, Goncalves, L, Epstein, SE, Chew, EY, Trapnell, CB, III, ROC, Quyyumi, AA, Stine, WTTAOA, Loscalzo, F, and Stiber, JA. "Effects of a single intracoronary injection of basic fibroblast growth factor in stable angina pectoris." American Journal of Cardiology 85, no. 12 (2000): 1414-1419.  Full Text
    • Lazarous, DF, Shou, M, Stiber, JA, Hodge, E, Thirumurti, V, Gonçalves, L, and Unger, EF. "Adenoviral-mediated gene transfer induces sustained pericardial VEGF expression in dogs: effect on myocardial angiogenesis." Cardiovasc Res 44, no. 2 (November 1999): 294-302.  Link to Item
    • Lazarous, DF, Shou, M, Stiber, JA, Dadhania, DM, Thirumurti, V, Hodge, E, and Unger, EF. "Pharmacodynamics of basic fibroblast growth factor: route of administration determines myocardial and systemic distribution." Cardiovasc Res 36, no. 1 (October 1997): 78-85.  Link to Item
    • Shou, M, Thirumurti, V, Rajanayagam, S, Lazarous, DF, Hodge, E, Stiber, JA, Pettiford, M, Elliott, E, Shah, SM, and Unger, EF. "Effect of basic fibroblast growth factor on myocardial angiogenesis in dogs with mature collateral vessels." J Am Coll Cardiol 29, no. 5 (April 1997): 1102-1106.  Link to Item
    • Lazarous, DF, Shou, M, Scheinowitz, M, Hodge, E, Thirumurti, V, Kitsiou, AN, Stiber, JA, Lobo, AD, Hunsberger, S, Guetta, E, Epstein, SE, and Unger, EF. "Comparative effects of basic fibroblast growth factor and vascular endothelial growth factor on coronary collateral development and the arterial response to injury." Circulation 94, no. 5 (September 1, 1996): 1074-1082.  Link to Item
    • Lazarous, DF, Scheinowitz, M, Shou, M, Hodge, E, Rajanayagam, S, Hunsberger, S, Robison, WG, Stiber, JA, Correa, R, and Epstein, SE. "Effects of chronic systemic administration of basic fibroblast growth factor on collateral development in the canine heart." Circulation 91, no. 1 (January 1, 1995): 145-153.  Link to Item

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