Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Fellow in Cardiology, Medicine, Duke University 2000 - 2004
  • Medical Resident, Medicine, Duke University 1997 - 2000
  • M.D., New York University 1997
• 

  Duke Appointment History

  • Associate Professor of Medicine, Medicine, Cardiology, Medicine 2016 - 2018
  • Assistant Professor of Medicine, Medicine, Cardiology, Medicine 2008 - 2016
  • Medical Instructor in the Department of Medicine, Medicine, Cardiology, Medicine 2004 - 2008
• Research
• 

  Selected Grants

  • Role of Drebrin in Atherosclerosis awarded by National Institutes of Health 2014 - 2019
  • Role of Drebrin in Vascular Smooth Muscle Remodeling awarded by National Institutes of Health 2013 - 2018
  • The role of STIM1 in cardiac and skeletal muscle function awarded by National Institutes of Health 2009 - 2014
  • Role of Homer Proteins in Calcium Signaling in Muscle awarded by National Institutes of Health 2005 - 2011
• Publications & Artistic Works
• 

  Selected Publications

  • Book Sections

    • Stiber, JA, and Rosenberg, PB. "Skeletal muscle store-operated Ca²⁺ entry and STIM/Orai signaling in skeletal muscle." In Store-operated Ca2+ entry (SOCE) pathways: Emerging signaling concepts in human (patho)physiology, 435-447. November 1, 2013.  Full Text

  • Conference Papers

    • Zhang, L, Wu, J-H, Huang, T-Q, Nepliouev, I, Brian, L, Zhang, Z, Rudemiller, NP, Crowley, SD, Freedman, NJ, and Stiber, JA. "Angiotensin II-Induced Aortic Inflammation and Remodeling Are Mitigated by the Actin-Binding Protein Drebrin." Scientific Sessions of the American-Heart-Association / Resuscitation Science Symposium. Anaheim, CA. November 11, 2017 - November 15, 2017.: LIPPINCOTT WILLIAMS & WILKINS, November 14, 2017.  Link to Item
    • Zhang, H, Sun, AY, Kim, JJ, Graham, V, Finch, EA, Nepliouev, I, Zhao, G, Li, T, Lederer, WJ, Stiber, JA, Pitt, GS, Bursac, N, and Rosenberg, PB. "STIM1-Ca2+ signaling modulates automaticity of the mouse sinoatrial node." October 2015.  Full Text
    • Black-Maier, EW, Wu, J-H, Fanaroff, AC, Akella, P, Zhang, L, Brian, L, Stiber, JA, Peppel, K, Eipper, BA, Mains, R, and Freedman, NJ. "The Dual RhoGEF Kalirin Reduces Atherosclerosis Through Endothelial Cell-Specific Mechanisms." November 26, 2013.  Link to Item
    • Stiber, JA, Zhang, L, Nepliouev, I, Zhang, Z-S, Wu, J-H, Rosenberg, PB, and Freedman, NJ. "The Actin-Binding Protein Drebrin Reduces TRP Channel Activity and Neointimal Hyperplasia." November 20, 2012.  Link to Item
    • Stiber, JA, Eu, JP, Seth, M, Tabatabaei, N, Hawkins, AF, Yamaguchi, N, Meissner, G, Williams, RS, and Rosenberg, PB. "Homer 1 loss of function results in a myopathy due to a defect in transient receptor potential channel activation." October 25, 2005.  Link to Item
    • Lazarous, DF, Shou, M, Stiber, JA, Dadhania, D, Thirumurti, V, Hodge, E, and Unger, EF. "Pharmacodynamics of basic fibroblast growth factor: Effect of route of administration on regional distribution." February 1997.  Link to Item
    • Lazarous, DF, Shou, M, Stiber, JA, Thirumurti, V, Hodge, E, and Unger, EF. "Adenoviral-mediated gene therapy induces sustained intrapericardial vascular endothelial growth factor expression in dogs: Effect on myocardial angiogenesis." February 1997.  Link to Item
    • Shou, M, Lazarous, DF, Stiber, JA, Thirumurti, V, Hodge, E, and Unger, EF. "The pericardium as a repository for an angiogenic growth factor: Effect of intrapericardial basic fibroblast growth factor on myocardial collateral development." February 1997.  Link to Item

  • Journal Articles

    • Zhang, L, Wu, J-H, Huang, T-Q, Nepliouev, I, Brian, L, Zhang, Z, Wertman, V, Rudemiller, NP, McMahon, TJ, Shenoy, SK, Miller, FJ, Crowley, SD, Freedman, NJ, and Stiber, JA. "Drebrin Regulates Angiotensin II-Induced Aortic Remodeling." Cardiovascular Research (June 20, 2018).  Full Text
    • Jean-Charles, P-Y, Yu, SM-W, Abraham, D, Kommaddi, RP, Mao, L, Strachan, RT, Zhang, Z-S, Bowles, DE, Brian, L, Stiber, JA, Jones, SN, Koch, WJ, Rockman, HA, and Shenoy, SK. "Mdm2 regulates cardiac contractility by inhibiting GRK2-mediated desensitization of β-adrenergic receptor signaling." JCI insight 2, no. 17 (September 7, 2017).  Full Text
    • Jackson, LR, Rathakrishnan, B, Campbell, K, Thomas, KL, Piccini, JP, Bahnson, T, Stiber, JA, and Daubert, JP. "Sinus Node Dysfunction and Atrial Fibrillation: A Reversible Phenomenon?." Pacing and clinical electrophysiology : PACE 40, no. 4 (April 2017): 442-450. (Review)  Full Text
    • Zhang, Z, Huang, T-Q, Nepliouev, I, Zhang, H, Barnett, AS, Rosenberg, PB, Ou, S-HI, and Stiber, JA. "Crizotinib Inhibits Hyperpolarization-activated Cyclic Nucleotide-Gated Channel 4 Activity." Cardio-oncology (London, England) 3 (January 19, 2017).  Full Text
    • Stiber, JA, Wu, J-H, Zhang, L, Nepliouev, I, Zhang, Z-S, Bryson, VG, Brian, L, Bentley, RC, Gordon-Weeks, PR, Rosenberg, PB, and Freedman, NJ. "The Actin-Binding Protein Drebrin Inhibits Neointimal Hyperplasia." Arteriosclerosis, Thrombosis, and Vascular Biology 36, no. 5 (May 2016): 984-993.  Full Text
    • Ou, S-HI, Tong, WP, Azada, M, Siwak-Tapp, C, Dy, J, and Stiber, JA. "Heart rate decrease during crizotinib treatment and potential correlation to clinical response." Cancer 119, no. 11 (June 1, 2013): 1969-1975.  Full Text  Link to Item
    • Ou, S-HI, Tong, WP, Azada, M, Siwak-Tapp, C, Dy, J, and Stiber, JA. "Heart rate decrease during crizotinib treatment and potential correlation to clinical response." Cancer 119, no. 11 (2013): 1969-1975.  Full Text
    • Stiber, JA, Tang, Y, Li, T, and Rosenberg, PB. "Cytoskeletal regulation of TRPC channels in the cardiorenal system." Curr Hypertens Rep 14, no. 6 (December 2012): 492-497. (Review)  Full Text  Link to Item
    • Seth, M, Li, T, Graham, V, Burch, J, Finch, E, Stiber, JA, and Rosenberg, PB. "Dynamic regulation of sarcoplasmic reticulum Ca(2+) stores by stromal interaction molecule 1 and sarcolipin during muscle differentiation." Dev Dyn 241, no. 4 (April 2012): 639-647.  Full Text  Link to Item
    • Ou, S-HI, Azada, M, Dy, J, and Stiber, JA. "Asymptomatic profound sinus bradycardia (heart rate ≤45) in non-small cell lung cancer patients treated with crizotinib." J Thorac Oncol 6, no. 12 (December 2011): 2135-2137.  Full Text  Link to Item
    • Stiber, JA, and Rosenberg, PB. "The role of store-operated calcium influx in skeletal muscle signaling." Cell Calcium 49, no. 5 (May 2011): 341-349. (Review)  Full Text
    • Nepliouev, I, Zhang, Z-S, and Stiber, JA. "Effect of oxidative stress on homer scaffolding proteins." Plos One 6, no. 10 (January 2011): e26128-null.  Full Text
    • Seth, M, Zhang, Z-S, Mao, L, Graham, V, Burch, J, Stiber, J, Tsiokas, L, Winn, M, Abramowitz, J, Rockman, HA, Birnbaumer, L, and Rosenberg, P. "TRPC1 channels are critical for hypertrophic signaling in the heart." Circulation Research 105, no. 10 (November 2009): 1023-1030.  Full Text
    • Stiber, JA, Seth, M, and Rosenberg, PB. "Mechanosensitive channels in striated muscle and the cardiovascular system: not quite a stretch anymore." Journal of Cardiovascular Pharmacology 54, no. 2 (August 2009): 116-122. (Review)  Full Text
    • Stiber, J, Hawkins, A, Zhang, Z-S, Wang, S, Burch, J, Graham, V, Ward, CC, Seth, M, Finch, E, Malouf, N, Williams, RS, Eu, JP, and Rosenberg, P. "STIM1 signalling controls store-operated calcium entry required for development and contractile function in skeletal muscle." Nature Cell Biology 10, no. 6 (June 2008): 688-697.  Full Text
    • Stiber, JA, Zhang, Z-S, Burch, J, Eu, JP, Zhang, S, Truskey, GA, Seth, M, Yamaguchi, N, Meissner, G, Shah, R, Worley, PF, Williams, RS, and Rosenberg, PB. "Mice lacking Homer 1 exhibit a skeletal myopathy characterized by abnormal transient receptor potential channel activity." Molecular and Cellular Biology 28, no. 8 (April 2008): 2637-2647.  Full Text
    • Rajagopal, K, Whalen, EJ, Violin, JD, Stiber, JA, Rosenberg, PB, Premont, RT, Coffman, TM, Rockman, HA, and Lefkowitz, RJ. "Beta-arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes." Proceedings of the National Academy of Sciences of the United States of America 103, no. 44 (October 23, 2006): 16284-16289.  Full Text
    • Du, W, McMahon, TJ, Zhang, Z-S, Stiber, JA, Meissner, G, and Eu, JP. "Excitation-contraction coupling in airway smooth muscle." J Biol Chem 281, no. 40 (October 6, 2006): 30143-30151.  Full Text  Link to Item
    • Stiber, JA, Tabatabaei, N, Hawkins, AF, Hawke, T, Worley, PF, Williams, RS, and Rosenberg, P. "Homer modulates NFAT-dependent signaling during muscle differentiation." Dev Biol 287, no. 2 (November 15, 2005): 213-224.  Full Text  Link to Item
    • Du, W, Stiber, JA, Rosenberg, PB, Meissner, G, and Eu, JP. "Ryanodine receptors in muscarinic receptor-mediated bronchoconstriction." J Biol Chem 280, no. 28 (July 15, 2005): 26287-26294.  Full Text  Link to Item
    • Du, WL, Stiber, JA, Rosenberg, PB, Meissner, G, and Eu, JP. "Ryanodine receptors in muscarinic receptor-mediated bronchoconstriction." JOURNAL OF BIOLOGICAL CHEMISTRY 280, no. 28 (July 15, 2005): 26287-26294.  Full Text  Link to Item
    • Rosenberg, P, Hawkins, A, Stiber, J, Shelton, JM, Hutcheson, K, Bassel-Duby, R, Shin, DM, Yan, Z, and Williams, RS. "TRPC3 channels confer cellular memory of recent neuromuscular activity." Proc Natl Acad Sci U S A 101, no. 25 (June 22, 2004): 9387-9392.  Full Text  Link to Item
    • Unger, EF, Goncalves, L, Epstein, SE, Chew, EY, Trapnell, CB, Cannon, RO, and Quyyumi, AA. "Effects of a single intracoronary injection of basic fibroblast growth factor in stable angina pectoris." The American Journal of Cardiology 85, no. 12 (June 2000): 1414-1419.  Full Text
    • Rajanayagam, MAS, Shou, M, Thirumurti, V, Lazarous, DF, Quyyumi, AA, Goncalves, L, Stiber, J, Epstein, SE, and Unger, EF. "Intracoronary basic fibroblast growth factor enhances myocardial collateral perfusion in dogs." Journal of the American College of Cardiology 35, no. 2 (2000): 519-526.  Full Text
    • Lazarous, DF, Shou, M, Stiber, JA, Hodge, E, Thirumurti, V, Gonçalves, L, and Unger, EF. "Adenoviral-mediated gene transfer induces sustained pericardial VEGF expression in dogs: effect on myocardial angiogenesis." Cardiovasc Res 44, no. 2 (November 1999): 294-302.  Link to Item
    • Lazarous, DF, Shou, M, Stiber, JA, Dadhania, DM, Thirumurti, V, Hodge, E, and Unger, EF. "Pharmacodynamics of basic fibroblast growth factor: route of administration determines myocardial and systemic distribution." Cardiovascular Research 36, no. 1 (October 1997): 78-85.  Full Text
    • Shou, M, Thirumurti, V, Rajanayagam, S, Lazarous, DF, Hodge, E, Stiber, JA, Pettiford, M, Elliott, E, Shah, SM, and Unger, EF. "Effect of basic fibroblast growth factor on myocardial angiogenesis in dogs with mature collateral vessels." J Am Coll Cardiol 29, no. 5 (April 1997): 1102-1106.  Link to Item
    • Lazarous, DF, Shou, M, Scheinowitz, M, Hodge, E, Thirumurti, V, Kitsiou, AN, Stiber, JA, Lobo, AD, Hunsberger, S, Guetta, E, Epstein, SE, and Unger, EF. "Comparative effects of basic fibroblast growth factor and vascular endothelial growth factor on coronary collateral development and the arterial response to injury." Circulation 94, no. 5 (September 1996): 1074-1082.  Full Text
    • Lazarous, DF, Scheinowitz, M, Shou, M, Hodge, E, Rajanayagam, S, Hunsberger, S, Robison, WG, Stiber, JA, Correa, R, and Epstein, SE. "Effects of chronic systemic administration of basic fibroblast growth factor on collateral development in the canine heart." Circulation 91, no. 1 (January 1995): 145-153.  Full Text

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