Current Appointments & Affiliations
Professor of Medicine
·
2022 - Present
Medicine, Cardiology,
Medicine
Recent Publications
Drebrin is Required for Myosin-facilitated Actin Cytoskeletal Remodeling during Pulmonary Alveolar Development.
Journal Article Am J Respir Cell Mol Biol · April 2024 Alveolar septation increases gas-exchange surface area and requires coordinated cytoskeletal rearrangement in lung fibroblasts (LFs) to balance the demands of contraction and cell migration. We hypothesized that DBN (drebrin), a modulator of the actin cyto ... Full text Link to item CitePhosphorylation of USP20 on Ser334 by IRAK1 promotes IL-1β-evoked signaling in vascular smooth muscle cells and vascular inflammation.
Journal Article J Biol Chem · July 2023 Reversible lysine-63 (K63) polyubiquitination regulates proinflammatory signaling in vascular smooth muscle cells (SMCs) and plays an integral role in atherosclerosis. Ubiquitin-specific peptidase 20 (USP20) reduces NFκB activation triggered by proinflamma ... Full text Open Access Link to item CiteSTIM1 interacts with HCN4 channels to coordinate diastolic depolarization in the mouse Sinoatrial node.
Journal Article bioRxiv · May 3, 2023 Cardiomyocytes in the sinoatrial node (SAN) are specialized to undergo spontaneous diastolic depolarization (DD) to create action potentials (AP) that serve as the origin of the heartbeat. Two cellular clocks govern DD: the membrane clock where ion channel ... Full text Link to item CiteRecent Grants
Anti-Atherogenic Mechanisms of Drebrin
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2019 - 2024Role of Debrin in Vascular Smooth Muscle Transdifferentiation
ResearchPrincipal Investigator · Awarded by American Heart Association · 2019 - 2019Role of Drebrin in Atherosclerosis
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2014 - 2019View All Grants
Education, Training & Certifications
New York University ·
1997
M.D.