Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Clinical Fellowship, Cardiovascular Disease, Duke University School of Medicine 2011 - 2013
  • Research Fellowship, Duke University School of Medicine 2008 - 2011
  • Resident, Internal Medicine, Duke University School of Medicine 2006 - 2008
  • M.D., University of Chicago 2006
  • Ph.D., University of Chicago 2004
• 

  Medical Licensure

  • 134545. North Carolina. 2009
• 

  Duke Appointment History

  • Assistant Professor of Medicine, Medicine, Cardiology, Medicine 2013 - 2017
  • Assistant Research Professor in Biochemistry, Biochemistry, Basic Science Departments 2015 - 2017
• Research
• 

  Selected Grants

  • CXCL10/CXCR3 regulation of ozone-induced epithelial permeability awarded by National Institutes of Health 2017 - 2022
  • TDE-HF-302 Open-label extension study of oral Treprostinil in subjects with Pulmonary Hypertension associated wiht Heart Failure with Preserved Ejection Fraction- A long-term follow-up to TDE-HF-301 awarded by United Therapeutics Corporation 2017 - 2022
  • Single Cell Profiling and Disease Modeling of CTEPH awarded by  American Heart Association 2019 - 2022
  • Biasing CXCR3 Signaling to Modulate the Inflammatory Response awarded by National Institutes of Health 2017 - 2022
  • Medical Scientist Training Program awarded by National Institutes of Health 1997 - 2022
  • Early Detection of Changes in Pulmonary Gas Exchange by Hyperpolarized Xe MRI awarded by National Institutes of Health 2011 - 2021
  • TRACE: Selexipag ACT-293987, AC-065A404 A multicenter double-blind placebo controlled Phase 4 study in patients with pulmonary arterial hypertension to assess the effect of selexipag awarded by Actelion Pharmaceutical US, Inc 2018 - 2020
  • Complexa PRIME - CXA-10-301 awarded by Complexa, Inc 2018 - 2020
  • UTC RIN-PH-201 awarded by United Therapeutics Corporation 2017 - 2020
  • UTC RIN-PH-202 awarded by United Therapeutics Corporation 2017 - 2020
  • Restrospective Study of Outcomes of Patients with WHO Groups 1 and 3 Pulmonary Hypertension Treated with High-Dose Inhaled Treprostinil awarded by United Therapeutics Corporation 2018 - 2020
  • ACTELION - OPUS REGISTRY awarded by Actelion Pharmaceuticals Ltd. 2015 - 2019
  • Non-invasive Diagnosis of Pulmonary Vascular Disease Using Inhaled 129Xe MRI awarded by National Institutes of Health 2016 - 2019
  • Dissecting Receptor Signaling Pathways in Pulmonary Hypertension awarded by Burroughs Wellcome Fund 2014 - 2019
  • Beta-Arrestin Regulation of VEGFR3 Signaling in Pulmonary Hypertension awarded by National Institutes of Health 2017 - 2019
  • Evaluate the Safety and Efficacy of Oral Treprostinil in Sbjects with Pulmonary Hypertension in Heart FAilure with Preserved Ejection Fraction (HFpEF) awarded by United Therapeutics Corporation 2017 - 2019
  • RV STRAIN awarded by Gilead Sciences, Inc. 2015 - 2019
  • Assessing Response to Inhaled Prostacyclin with Hyperpolarized 129Xe MRI awarded by United Therapeutics Corporation 2017 - 2018
  • LIBERTY awarded by Eiger BioPharmaceuticals, Inc. 2016 - 2018
  • Opsummit Historical Users cohort study (OrPHeUS) awarded by Actelion Pharmaceuticals Ltd. 2018
  • Eiger EIG-UBX-002 awarded by Eiger BioPharmaceuticals, Inc. 2016 - 2018
  • Noncanonical Receptor Signaling in Pulmonary Arterial Hypertension awarded by National Institutes of Health 2013 - 2018
  • CardioMEMS awarded by Pacesetter, Inc. 2016 - 2018
  • Investigation of the Effect of Expressing BMPr2, BMP10 or BMP9 in the monocrotaline rat model (MCT) and sugen-hypoxia model (SuHX) for PAH following the systemic delivery of genes using an AAV vector. awarded by StrideBio LLC 2017 - 2018
  • A Pilot Study of Transitioning from Parenteral Prostacyclins to Selexipag awarded by Actelion Pharmaceutical US, Inc 2017
  • Targeting the Right Ventricle with Biased Agonists in Pulmonary Arterial Hypertension awarded by Gilead Sciences, Inc. 2014 - 2016
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Parikh, Kishan S., Talal Dahhan, Leigh Nicholl, Nicole Ruopp, Gina-Maria Pomann, Terry Fortin, Victor F. Tapson, and Sudarshan Rajagopal. “Clinical Features and Outcomes of Patients with Sarcoidosis-associated Pulmonary Hypertension..” Scientific Reports 9, no. 1 (March 11, 2019). https://doi.org/10.1038/s41598-019-40030-w.
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    • Ghadimi, Kamrouz, and Sudarshan Rajagopal. “Nasally Inhaled Nitric Oxide for Sudden Right-Sided Heart Failure in the Intensive Care Unit: NO Time Like the Present..” Journal of Cardiothoracic and Vascular Anesthesia 33, no. 3 (March 2019): 648–50. https://doi.org/10.1053/j.jvca.2018.10.008.
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    • Ma, Zhiyuan, Yen-Rei Yu, Cristian T. Badea, Jeffrey J. Kovacs, Xinyu Xiong, Suzy Comhair, Claude A. Piantadosi, and Sudarshan Rajagopal. “Vascular Endothelial Growth Factor Receptor 3 Regulates Endothelial Function Through β-Arrestin 1..” Circulation 139, no. 13 (March 2019): 1629–42. https://doi.org/10.1161/circulationaha.118.034961.
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    • Rajarathnam, Krishna, Michael Schnoor, Ricardo M. Richardson, and Sudarshan Rajagopal. “How do chemokines navigate neutrophils to the target site: Dissecting the structural mechanisms and signaling pathways..” Cellular Signalling 54 (February 2019): 69–80. https://doi.org/10.1016/j.cellsig.2018.11.004.
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    • Bier, Elianna A., Scott H. Robertson, Geoffry M. Schrank, Craig Rackley, Joseph G. Mammarappallil, Sudarshan Rajagopal, H Page McAdams, and Bastiaan Driehuys. “A protocol for quantifying cardiogenic oscillations in dynamic 129 Xe gas exchange spectroscopy: The effects of idiopathic pulmonary fibrosis..” Nmr in Biomedicine 32, no. 1 (January 2019). https://doi.org/10.1002/nbm.4029.
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    • Loyalka, Pranav, Muhammad Z. Ansari, Faisal H. Cheema, Charles C. Miller, Sudarshan Rajagopal, and Keshava Rajagopal. “Surgical pulmonary embolectomy and catheter-based therapies for acute pulmonary embolism: A contemporary systematic review..” The Journal of Thoracic and Cardiovascular Surgery 156, no. 6 (December 2018): 2155–67. https://doi.org/10.1016/j.jtcvs.2018.05.085.
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    • Wang, Ziyi, Mu He, Elianna Bier, Leith Rankine, Geoffry Schrank, Sudarshan Rajagopal, Yuh-Chin Huang, et al. “Hyperpolarized 129 Xe gas transfer MRI: the transition from 1.5T to 3T..” Magn Reson Med 80, no. 6 (December 2018): 2374–83. https://doi.org/10.1002/mrm.27377.
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    • Smith, Jeffrey S., Lowell T. Nicholson, Jutamas Suwanpradid, Rachel A. Glenn, Nicole M. Knape, Priya Alagesan, Jaimee N. Gundry, et al. “Biased agonists of the chemokine receptor CXCR3 differentially control chemotaxis and inflammation..” Science Signaling 11, no. 555 (November 6, 2018). https://doi.org/10.1126/scisignal.aaq1075.
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    • Alenezi, Fawaz, Aditya Mandawat, Zachary J. Il’Giovine, Linda K. Shaw, Irfan Siddiqui, Victor F. Tapson, Kristine Arges, et al. “Clinical Utility and Prognostic Value of Right Atrial Function in Pulmonary Hypertension..” Circulation. Cardiovascular Imaging 11, no. 11 (November 2018). https://doi.org/10.1161/circimaging.117.006984.
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    • Luttrell, Louis M., Jialu Wang, Bianca Plouffe, Jeffrey S. Smith, Lama Yamani, Suneet Kaur, Pierre-Yves Jean-Charles, et al. “Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9..” Science Signaling 11, no. 549 (September 25, 2018). https://doi.org/10.1126/scisignal.aat7650.
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    • Siddiqui, Irfan, Sudarshan Rajagopal, Amanda Brucker, Karen Chiswell, Bridgette Christopher, Fawaz Alenezi, Aditya Mandawat, et al. “Clinical and Echocardiographic Predictors of Outcomes in Patients With Pulmonary Hypertension..” The American Journal of Cardiology 122, no. 5 (September 2018): 872–78. https://doi.org/10.1016/j.amjcard.2018.05.019.
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    • Smith, Jeffrey S., Sudarshan Rajagopal, and Amber Reck Atwater. “Chemokine Signaling in Allergic Contact Dermatitis: Toward Targeted Therapies..” Dermatitis : Contact, Atopic, Occupational, Drug 29, no. 4 (July 2018): 179–86. https://doi.org/10.1097/der.0000000000000391.
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    • Il’Giovine, Zachary J., Hillary Mulder, Karen Chiswell, Kristine Arges, Jennifer Tomfohr, Abraham Hashmi, Eric J. Velazquez, Joseph A. Kisslo, Zainab Samad, and Sudarshan Rajagopal. “Right Ventricular Longitudinal Strain Reproducibility Using Vendor-Dependent and Vendor-Independent Software..” Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography 31, no. 6 (June 2018): 721-732.e5. https://doi.org/10.1016/j.echo.2018.01.008.
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    • Smith, Jeffrey S., Robert J. Lefkowitz, and Sudarshan Rajagopal. “Biased signalling: from simple switches to allosteric microprocessors..” Nature Reviews. Drug Discovery 17, no. 4 (April 2018): 243–60. https://doi.org/10.1038/nrd.2017.229.
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    • Rajagopal, Sudarshan, and Sudha K. Shenoy. “GPCR desensitization: Acute and prolonged phases..” Cellular Signalling 41 (January 2018): 9–16. https://doi.org/10.1016/j.cellsig.2017.01.024.
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    • Broderick-Forsgren, Kathleen, Clemontina A. Davenport, Joseph A. Sivak, Charles William Hargett, Michael C. Foster, Andrew Monteagudo, Alicia Armour, et al. “Improving on the diagnostic characteristics of echocardiography for pulmonary hypertension..” The International Journal of Cardiovascular Imaging 33, no. 9 (September 2017): 1341–49. https://doi.org/10.1007/s10554-017-1114-2.
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    • Smith, Jeffrey S., Priya Alagesan, Nimit K. Desai, Thomas F. Pack, Jiao-Hui Wu, Asuka Inoue, Neil J. Freedman, and Sudarshan Rajagopal. “C-X-C Motif Chemokine Receptor 3 Splice Variants Differentially Activate Beta-Arrestins to Regulate Downstream Signaling Pathways..” Molecular Pharmacology 92, no. 2 (August 2017): 136–50. https://doi.org/10.1124/mol.117.108522.
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    • Wang, Ziyi, Scott Haile Robertson, Jennifer Wang, Mu He, Rohan S. Virgincar, Geoffry M. Schrank, Elianna A. Bier, et al. “Quantitative analysis of hyperpolarized 129 Xe gas transfer MRI..” Medical Physics 44, no. 6 (June 2017): 2415–28. https://doi.org/10.1002/mp.12264.
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    • Parikh, Kishan S., Youlan Rao, Tariq Ahmad, Kai Shen, G Michael Felker, and Sudarshan Rajagopal. “Novel approach to classifying patients with pulmonary arterial hypertension using cluster analysis..” Pulmonary Circulation 7, no. 2 (April 2017): 486–93. https://doi.org/10.1177/2045893217705891.
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    • Onaran, H Ongun, Caterina Ambrosio, Özlem Uğur, Erzsebet Madaras Koncz, Maria Cristina Grò, Vanessa Vezzi, Sudarshan Rajagopal, and Tommaso Costa. “Systematic errors in detecting biased agonism: Analysis of current methods and development of a new model-free approach..” Scientific Reports 7 (March 14, 2017). https://doi.org/10.1038/srep44247.
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    • Luo, Nancy, Damian Craig, Olga Ilkayeva, Michael Muehlbauer, William E. Kraus, Christopher B. Newgard, Svati H. Shah, and Sudarshan Rajagopal. “Plasma acylcarnitines are associated with pulmonary hypertension..” Pulmonary Circulation 7, no. 1 (March 2017): 211–18. https://doi.org/10.1086/690554.
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    • Dahhan, Talal, Fawaz Alenezi, Zainab Samad, and Sudarshan Rajagopal. “Echocardiography in the Risk Assessment of Acute Pulmonary Embolism..” Seminars in Respiratory and Critical Care Medicine 38, no. 1 (February 16, 2017): 18–28. https://doi.org/10.1055/s-0036-1597563.
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    • Gundry, J., R. Glenn, P. Alagesan, and S. Rajagopal. “A practical guide to approaching biased agonism at G protein coupled receptors.” Frontiers in Neuroscience 11, no. JAN (January 1, 2017). https://doi.org/10.3389/fnins.2017.00017.
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    • Dahhan, T., I. Siddiqui, V. F. Tapson, E. J. Velazquez, S. Sun, C. A. Davenport, Z. Samad, and S. Rajagopal. “Clinical and echocardiographic predictors of mortality in acute pulmonary embolism.” Cardiovascular Ultrasound 14, no. 1 (October 28, 2016).
    • Dahhan, Talal, Irfan Siddiqui, Victor F. Tapson, Eric J. Velazquez, Stephanie Sun, Clemontina A. Davenport, Zainab Samad, and Sudarshan Rajagopal. “Clinical and echocardiographic predictors of mortality in acute pulmonary embolism..” Cardiovascular Ultrasound 14, no. 1 (October 28, 2016). https://doi.org/10.1186/s12947-016-0087-y.
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    • Smith, Jeffrey S., and Sudarshan Rajagopal. “The β-Arrestins: Multifunctional Regulators of G Protein-coupled Receptors..” J Biol Chem 291, no. 17 (April 22, 2016): 8969–77. https://doi.org/10.1074/jbc.R115.713313.
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    • Ma, Zhiyuan, Lan Mao, and Sudarshan Rajagopal. “Hemodynamic Characterization of Rodent Models of Pulmonary Arterial Hypertension..” Journal of Visualized Experiments : Jove, no. 110 (April 11, 2016). https://doi.org/10.3791/53335.
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    • Parikh, Kishan S., Sudarshan Rajagopal, Terry Fortin, Victor F. Tapson, and Abby D. Poms. “Safety and Tolerability of High-dose Inhaled Treprostinil in Pulmonary Hypertension..” Journal of Cardiovascular Pharmacology 67, no. 4 (April 2016): 322–25. https://doi.org/10.1097/FJC.0000000000000357.
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    • Dahhan, Talal, Shiv S. Kaushik, Mu He, Joseph G. Mammarappallil, Victor F. Tapson, Holman P. McAdams, Thomas A. Sporn, Bastiaan Driehuys, and Sudarshan Rajagopal. “Abnormalities in hyperpolarized (129)Xe magnetic resonance imaging and spectroscopy in two patients with pulmonary vascular disease..” Pulmonary Circulation 6, no. 1 (March 2016): 126–31. https://doi.org/10.1086/685110.
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    • Parikh, Kishan S., Sudarshan Rajagopal, Kristine Arges, Tariq Ahmad, Joseph Sivak, Prashant Kaul, Svati H. Shah, et al. “Use of outcome measures in pulmonary hypertension clinical trials..” American Heart Journal 170, no. 3 (September 2015): 419-29.e3. https://doi.org/10.1016/j.ahj.2015.06.010.
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    • Forsha, Daniel, Niels Risum, Sudarshan Rajagopal, Stephen Dolgner, Christoph Hornik, Huiman Barnhart, Joseph Kisslo, and Piers Barker. “The influence of angle of insonation and target depth on speckle-tracking strain..” J Am Soc Echocardiogr 28, no. 5 (May 2015): 580–86. https://doi.org/10.1016/j.echo.2014.12.015.
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    • Onaran, H Ongun, Sudarshan Rajagopal, and Tommaso Costa. “What is biased efficacy? Defining the relationship between intrinsic efficacy and free energy coupling..” Trends in Pharmacological Sciences 35, no. 12 (December 2014): 639–47. https://doi.org/10.1016/j.tips.2014.09.010.
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    • Rajagopal, Sudarshan, Daniel E. Forsha, Niels Risum, Christoph P. Hornik, Abby D. Poms, Terry A. Fortin, Victor F. Tapson, Eric J. Velazquez, Joseph Kisslo, and Zainab Samad. “Comprehensive assessment of right ventricular function in patients with pulmonary hypertension with global longitudinal peak systolic strain derived from multiple right ventricular views..” Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography 27, no. 6 (June 2014): 657-665.e3. https://doi.org/10.1016/j.echo.2014.02.001.
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    • Forsha, Daniel, Niels Risum, P Andrea Kropf, Sudarshan Rajagopal, P Brian Smith, Ronald J. Kanter, Zainab Samad, Peter Sogaard, Piers Barker, and Joseph Kisslo. “Right ventricular mechanics using a novel comprehensive three-view echocardiographic strain analysis in a normal population..” J Am Soc Echocardiogr 27, no. 4 (April 2014): 413–22. https://doi.org/10.1016/j.echo.2013.12.018.
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    • Forsha, D., N. Risum, P. A. Kropf, S. Rajagopal, P. B. Smith, R. J. Kanter, Z. Samad, P. Sogaard, P. Barker, and J. Kisslo. “Right ventricular mechanics using a novel comprehensive three-view echocardiographic strain analysis in a normal population.” Journal of the American Society of Echocardiography 27, no. 4 (January 1, 2014): 413–22. https://doi.org/10.1016/j.echo.2013.12.018.
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    • Kahsai, Alem W., Sudarshan Rajagopal, Jinpeng Sun, and Kunhong Xiao. “Monitoring protein conformational changes and dynamics using stable-isotope labeling and mass spectrometry..” Nature Protocols 9, no. 6 (January 2014): 1301–19. https://doi.org/10.1038/nprot.2014.075.
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    • Rajagopal, S., D. E. Forsha, N. Risum, C. P. Hornik, A. D. Poms, T. A. Fortin, V. F. Tapson, E. J. Velazquez, J. Kisslo, and Z. Samad. “Comprehensive assessment of right ventricular function in patients with pulmonary hypertension with global longitudinal peak systolic strain derived from multiple right ventricular views.” Journal of the American Society of Echocardiography 27, no. 6 (January 1, 2014): 657-665.e3. https://doi.org/10.1016/j.echo.2014.02.001.
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    • Rajagopal, Sudarshan, Daniel L. Bassoni, James J. Campbell, Norma P. Gerard, Craig Gerard, and Tom S. Wehrman. “Biased agonism as a mechanism for differential signaling by chemokine receptors..” The Journal of Biological Chemistry 288, no. 49 (December 2013): 35039–48. https://doi.org/10.1074/jbc.M113.479113.
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    • Rajagopal, Sudarshan. “Quantifying biased agonism: understanding the links between affinity and efficacy..” Nature Reviews. Drug Discovery 12, no. 6 (June 2013). https://doi.org/10.1038/nrd3954-c1.
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    • Xiao, K., J. Sun, J. Kim, S. Rajagopal, B. Zhai, J. Villén, W. Haas, et al. “Erratum: Global phosphorylation analysis of ß-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR) (Proceedings of the National Academy of Sciences of the United States of America (2010) 107, 34 (15299-15304) doi:10.1073/pnas.1008461107).” Proceedings of the National Academy of Sciences of the United States of America 109, no. 33 (August 14, 2012). https://doi.org/10.1073/pnas.1211889109.
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    • Rajagopal, Sudarshan, Seungkirl Ahn, David H. Rominger, William Gowen-MacDonald, Christopher M. Lam, Scott M. Dewire, Jonathan D. Violin, and Robert J. Lefkowitz. “Quantifying ligand bias at seven-transmembrane receptors..” Mol Pharmacol 80, no. 3 (September 2011): 367–77. https://doi.org/10.1124/mol.111.072801.
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    • Hara, Makoto R., Jeffrey J. Kovacs, Erin J. Whalen, Sudarshan Rajagopal, Ryan T. Strachan, Wayne Grant, Aaron J. Towers, et al. “A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1..” Nature 477, no. 7364 (August 21, 2011): 349–53. https://doi.org/10.1038/nature10368.
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    • Kahsai, Alem W., Kunhong Xiao, Sudarshan Rajagopal, Seungkirl Ahn, Arun K. Shukla, Jinpeng Sun, Terrence G. Oas, and Robert J. Lefkowitz. “Multiple ligand-specific conformations of the β2-adrenergic receptor..” Nat Chem Biol 7, no. 10 (August 21, 2011): 692–700. https://doi.org/10.1038/nchembio.634.
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    • Nobles, Kelly N., Kunhong Xiao, Seungkirl Ahn, Arun K. Shukla, Christopher M. Lam, Sudarshan Rajagopal, Ryan T. Strachan, et al. “Distinct phosphorylation sites on the β(2)-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin..” Sci Signal 4, no. 185 (August 9, 2011). https://doi.org/10.1126/scisignal.2001707.
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    • Whalen, Erin J., Sudarshan Rajagopal, and Robert J. Lefkowitz. “Therapeutic potential of β-arrestin- and G protein-biased agonists..” Trends in Molecular Medicine 17, no. 3 (March 2011): 126–39. https://doi.org/10.1016/j.molmed.2010.11.004.
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    • Xiao, Kunhong, Jinpeng Sun, Jihee Kim, Sudarshan Rajagopal, Bo Zhai, Judit Villén, Wilhelm Haas, et al. “Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR)..” Proceedings of the National Academy of Sciences of the United States of America 107, no. 34 (August 4, 2010): 15299–304. https://doi.org/10.1073/pnas.1008461107.
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    • Rajagopal, Sudarshan, Keshava Rajagopal, and Robert J. Lefkowitz. “Teaching old receptors new tricks: biasing seven-transmembrane receptors..” Nature Reviews. Drug Discovery 9, no. 5 (May 2010): 373–86. https://doi.org/10.1038/nrd3024.
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    • Rajagopal, Sudarshan, Jihee Kim, Seungkirl Ahn, Stewart Craig, Christopher M. Lam, Norma P. Gerard, Craig Gerard, and Robert J. Lefkowitz. “Beta-arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7..” Proceedings of the National Academy of Sciences of the United States of America 107, no. 2 (January 2010): 628–32. https://doi.org/10.1073/pnas.0912852107.
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    • Rajagopal, Sudarshan, and Stephen B. H. Kent. “Total chemical synthesis and biophysical characterization of the minimal isoform of the KChIP2 potassium channel regulatory subunit..” Protein Science : A Publication of the Protein Society 16, no. 9 (September 2007): 2056–64. https://doi.org/10.1110/ps.072876107.
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    • Ihee, Hyotcherl, Sudarshan Rajagopal, Vukica Srajer, Reinhard Pahl, Spencer Anderson, Marius Schmidt, Friedrich Schotte, Philip A. Anfinrud, Michael Wulff, and Keith Moffat. “Visualizing reaction pathways in photoactive yellow protein from nanoseconds to seconds..” Proceedings of the National Academy of Sciences of the United States of America 102, no. 20 (May 3, 2005): 7145–50. https://doi.org/10.1073/pnas.0409035102.
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    • Rajagopal, Sudarshan, Spencer Anderson, Vukica Srajer, Marius Schmidt, Reinhard Pahl, and Keith Moffat. “A structural pathway for signaling in the E46Q mutant of photoactive yellow protein..” Structure (London, England : 1993) 13, no. 1 (January 2005): 55–63. https://doi.org/10.1016/j.str.2004.10.016.
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    • Rajagopal, Sudarshan, Jason M. Key, Erin B. Purcell, David J. Boerema, and Keith Moffat. “Purification and initial characterization of a putative blue light-regulated phosphodiesterase from Escherichia coli..” Photochemistry and Photobiology 80, no. 3 (November 2004): 542–47. https://doi.org/10.1562/2004-06-16-ra-203.
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    • Rajagopal, Sudarshan, Konstantin S. Kostov, and Keith Moffat. “Analytical trapping: extraction of time-independent structures from time-dependent crystallographic data..” Journal of Structural Biology 147, no. 3 (September 2004): 211–22. https://doi.org/10.1016/j.jsb.2004.04.007.
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    • Anderson, Spencer, Vukica Srajer, Reinhard Pahl, Sudarshan Rajagopal, Friedrich Schotte, Philip Anfinrud, Michael Wulff, and Keith Moffat. “Chromophore conformation and the evolution of tertiary structural changes in photoactive yellow protein..” Structure (London, England : 1993) 12, no. 6 (June 2004): 1039–45. https://doi.org/10.1016/j.str.2004.04.008.
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    • Rajagopal, Sudarshan, Marius Schmidt, Spencer Anderson, Hyotcherl Ihee, and Keith Moffat. “Analysis of experimental time-resolved crystallographic data by singular value decomposition..” Acta Crystallographica. Section D, Biological Crystallography 60, no. Pt 5 (May 2004): 860–71. https://doi.org/10.1107/s0907444904004160.
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    • Schmidt, Marius, Reinhard Pahl, Vukica Srajer, Spencer Anderson, Zhong Ren, Hyotcherl Ihee, Sudarshan Rajagopal, and Keith Moffat. “Protein kinetics: structures of intermediates and reaction mechanism from time-resolved x-ray data..” Proceedings of the National Academy of Sciences of the United States of America 101, no. 14 (April 2004): 4799–4804. https://doi.org/10.1073/pnas.0305983101.
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    • Rajagopal, S., J. M. Key, E. B. Purcell, D. J. Boerema, and K. Moffat. “Purification and initial characterization of a putative blue light-regulated phosphodiesterase from Escherichia coli.” Photochemistry and Photobiology 80, no. 3 (January 1, 2004): 542–47. https://doi.org/10.1562/0031-8655(2004)080<0542:PAICOA>2.0.CO;2.
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    • Rajagopal, S., and K. Moffat. “Erratum: Crystal structure of a photoactive yellow protein from a sensor histidine kinase: Conformational variability and signal transduction (Proceedings of the National Academy of Sciences of the United States of America (February 18, 2003) 100:4 (1649-1654).” Proceedings of the National Academy of Sciences of the United States of America 100, no. 13 (June 24, 2003). https://doi.org/10.1073/pnas.1432896100.
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    • Schmidt, Marius, Sudarshan Rajagopal, Zhong Ren, and Keith Moffat. “Application of singular value decomposition to the analysis of time-resolved macromolecular x-ray data..” Biophysical Journal 84, no. 3 (March 2003): 2112–29. https://doi.org/10.1016/s0006-3495(03)75018-8.
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    • Rajagopal, Sudarshan, and Keith Moffat. “Crystal structure of a photoactive yellow protein from a sensor histidine kinase: conformational variability and signal transduction..” Proceedings of the National Academy of Sciences of the United States of America 100, no. 4 (February 2003): 1649–54. https://doi.org/10.1073/pnas.0336353100.
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    • Crosson, Sean, Sudarshan Rajagopal, and Keith Moffat. “The LOV domain family: photoresponsive signaling modules coupled to diverse output domains..” Biochemistry 42, no. 1 (January 2003): 2–10. https://doi.org/10.1021/bi026978l.
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• Teaching & Mentoring
• 

  Recent Courses

  • BIOCHEM 393: Research Independent Study 2019
  • BIOCHEM 593: Research Independent Study 2019
  • PHARM 493: Research Independent Study 2019
  • PHARM 494: Research Independent Study 2019

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