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Linda Marie Sutton

Professor of Medicine
Medicine, Medical Oncology
Duke Box 2989, Durham, NC 27710
615 Douglas Street, Suite 600, Durham, NC 27705

Selected Publications


Improving well-being for individuals with persistent pain after surgery for breast cancer, lobular carcinoma in situ, or ductal carcinoma in situ: A randomized clinical trial.

Journal Article Contemp Clin Trials · November 2022 >276,000 Americans will be diagnosed with invasive breast cancer, lobular carcinoma in situ, or ductal carcinoma in situ this year and most will undergo breast surgery as part of their care. Although prognosis is excellent, many patients experience persist ... Full text Link to item Cite

Increasing physical activity in Cancer Survivors through a Text-messaging Exercise motivation Program (ICanSTEP).

Journal Article Support Care Cancer · December 2021 PURPOSE: Cancer survivors are often sedentary. Self-monitoring may promote physical activity through self-activation. We conducted a pilot trial to evaluate whether wearable activity tracker with personalized text message feedback would increase physical a ... Full text Link to item Cite

Low-touch, team-based care for co-morbidity management in cancer patients: the ONE TEAM randomized controlled trial.

Journal Article BMC Fam Pract · November 18, 2021 BACKGROUND: As treatments for cancer have improved, more people are surviving cancer. However, compared to people without a history of cancer, cancer survivors are more likely to die of cardiovascular disease (CVD). Increased risk for CVD-related mortality ... Full text Link to item Cite

Hereditary Cancer Counseling and Germline Genetic Testing

Chapter · September 15, 2021 Screening for inherited predisposition to cancer and germline genetic testing are part of the standard of care for breast cancer management, with implications for immediate and survivorship management. The advent of multigene next-generation sequencing pan ... Full text Link to item Cite

NCCN GuidelinesĀ® Insights: Palliative Care, Version 2.2021.

Journal Article J Natl Compr Canc Netw · July 28, 2021 Palliative care has evolved to be an integral part of comprehensive cancer care with the goal of early intervention to improve quality of life and patient outcomes. The NCCN Guidelines for Palliative Care provide recommendations to help the primary oncolog ... Full text Link to item Cite

Behavioral cancer pain intervention using videoconferencing and a mobile application for medically underserved patients: Rationale, design, and methods of a prospective multisite randomized controlled trial.

Journal Article Contemp Clin Trials · March 2021 BACKGROUND: Women with breast cancer in medically underserved areas are particularly vulnerable to persistent pain and disability. Behavioral pain interventions reduce pain and improve outcomes. Cancer patients in medically underserved areas receive limite ... Full text Link to item Cite

Preface

Book · January 1, 2021 Cite

Common Issues in Breast Cancer Survivors: A Practical Guide to Evaluation and Management

Book · January 1, 2021 This book provides a clinically useful resource for evaluation and management of the symptoms and issues that burden survivors of breast cancer. Improvements to breast cancer screening and treatment have resulted in more patients than ever before having be ... Full text Cite

Overview of the National and International Guidelines for Care of Breast Cancer Survivors

Chapter · January 1, 2021 Medical management guidelines provide lifelines for busy clinicians trying to determine the best approach for individual patient scenarios. By identifying, collating, reviewing, and categorizing published results, guidelines save time and provide valuable ... Full text Cite

Improving health engagement and lifestyle management for breast cancer survivors with diabetes.

Journal Article Contemp Clin Trials · May 2020 Breast cancer survivors with type 2 diabetes are at high risk for cancer recurrence, serious health complications, more severe symptoms, psychological distress, and premature death relative to breast cancer survivors without diabetes. Maintaining glycemic ... Full text Open Access Link to item Cite

The need for a Serious Illness Digital Ecosystem (SIDE) to improve outcomes for patients receiving palliative and hospice care.

Journal Article Am J Manag Care · April 2020 Palliative and hospice care services produce immense benefits for patients living with serious illness and for their families. Due to the national shift toward value-based payment models, health systems and payers share a heightened awareness of the need t ... Full text Open Access Link to item Cite

Coping Skills Training and Acceptance and Commitment Therapy for Symptom Management: Feasibility and Acceptability of a Brief Telephone-Delivered Protocol for Patients With Advanced Cancer.

Journal Article J Pain Symptom Manage · February 2020 CONTEXT: Patients with advanced cancer face a life-limiting condition that brings a high symptom burden that often includes pain, fatigue, and psychological distress. Psychosocial interventions have promise for managing symptoms but need additional tailori ... Full text Link to item Cite

Randomized Trial of Standard Adjuvant Chemotherapy Regimens Versus Capecitabine in Older Women With Early Breast Cancer: 10-Year Update of the CALGB 49907 Trial.

Journal Article J Clin Oncol · September 10, 2019 PURPOSE: Older women with breast cancer remain under-represented in clinical trials. The Cancer and Leukemia Group B 49907 trial focused on women age 65 years and older. We previously reported the primary analysis after a median follow-up of 2.4 years. Sta ... Full text Link to item Cite

Testing a behavioral intervention to improve adherence to adjuvant endocrine therapy (AET).

Journal Article Contemp Clin Trials · January 2019 Adjuvant endocrine therapy (AET) is used to prevent recurrence and reduce mortality for women with hormone receptor positive breast cancer. Poor adherence to AET is a significant problem and contributes to increased medical costs and mortality. A variety o ... Full text Open Access Link to item Cite

Development and pilot testing of an mHealth behavioral cancer pain protocol for medically underserved communities.

Journal Article J Psychosoc Oncol · 2019 The purpose of this study was to refine and test a mobile-health behavioral cancer pain coping skills training protocol for women with breast cancer and pain from medically underserved areas. Three focus groups (Phase 1) were used to refine the initial pro ... Full text Link to item Cite

A smoking cessation and pain management program for cancer survivors.

Journal Article J Cancer Surviv · December 2018 PURPOSE: Many cancer survivors continue to smoke. Further, most survivors also report high levels of persistent pain and smoke in response to pain. The investigators tested the feasibility, acceptability, and preliminary efficacy of a smoking cessation pro ... Full text Link to item Cite

The preference to receive chemotherapy and cancer-related outcomes in older adults with breast cancer CALGB 49907 (Alliance).

Journal Article J Geriatr Oncol · May 2018 OBJECTIVE: Chemotherapy preference refers to a patient's interest in receiving chemotherapy. This study examined whether chemotherapy preference was associated with toxicity, efficacy, quality of life (QoL), and functional outcomes during and after complet ... Full text Link to item Cite

NCCN Guidelines Insights: Palliative Care, Version 2.2017.

Journal Article J Natl Compr Canc Netw · August 2017 The NCCN Guidelines for Palliative Care provide interdisciplinary recommendations on palliative care for patients with cancer. These NCCN Guidelines Insights summarize and provide context for the updated guidelines recommendations regarding hospice and end ... Full text Link to item Cite

Palliative Care Version 1.2016.

Journal Article J Natl Compr Canc Netw · January 2016 The NCCN Guidelines for Palliative Care provide interdisciplinary recommendations on palliative care for patients with cancer. The NCCN Guidelines are intended to provide guidance to the primary oncology team on the integration of palliative care into onco ... Full text Link to item Cite

CHAMBER: A Regional Performance Improvement CME Initiative for Breast Cancer Health Care Providers.

Journal Article J Natl Compr Canc Netw · August 2015 CHAMBER was a regional educational initiative for providers of care to patients with HER2+ breast cancer. The study goals were to (1) enhance testing for HER2/neu overexpression in patients with invasive breast cancer; (2) increase the appropriate use of t ... Full text Link to item Cite

Improving well-being for individuals with persistent pain after surgery for breast cancer, lobular carcinoma in situ, or ductal carcinoma in situ: A randomized clinical trial.

Journal Article Contemp Clin Trials · November 2022 >276,000 Americans will be diagnosed with invasive breast cancer, lobular carcinoma in situ, or ductal carcinoma in situ this year and most will undergo breast surgery as part of their care. Although prognosis is excellent, many patients experience persist ... Full text Link to item Cite

Increasing physical activity in Cancer Survivors through a Text-messaging Exercise motivation Program (ICanSTEP).

Journal Article Support Care Cancer · December 2021 PURPOSE: Cancer survivors are often sedentary. Self-monitoring may promote physical activity through self-activation. We conducted a pilot trial to evaluate whether wearable activity tracker with personalized text message feedback would increase physical a ... Full text Link to item Cite

Low-touch, team-based care for co-morbidity management in cancer patients: the ONE TEAM randomized controlled trial.

Journal Article BMC Fam Pract · November 18, 2021 BACKGROUND: As treatments for cancer have improved, more people are surviving cancer. However, compared to people without a history of cancer, cancer survivors are more likely to die of cardiovascular disease (CVD). Increased risk for CVD-related mortality ... Full text Link to item Cite

Hereditary Cancer Counseling and Germline Genetic Testing

Chapter · September 15, 2021 Screening for inherited predisposition to cancer and germline genetic testing are part of the standard of care for breast cancer management, with implications for immediate and survivorship management. The advent of multigene next-generation sequencing pan ... Full text Link to item Cite

NCCN GuidelinesĀ® Insights: Palliative Care, Version 2.2021.

Journal Article J Natl Compr Canc Netw · July 28, 2021 Palliative care has evolved to be an integral part of comprehensive cancer care with the goal of early intervention to improve quality of life and patient outcomes. The NCCN Guidelines for Palliative Care provide recommendations to help the primary oncolog ... Full text Link to item Cite

Behavioral cancer pain intervention using videoconferencing and a mobile application for medically underserved patients: Rationale, design, and methods of a prospective multisite randomized controlled trial.

Journal Article Contemp Clin Trials · March 2021 BACKGROUND: Women with breast cancer in medically underserved areas are particularly vulnerable to persistent pain and disability. Behavioral pain interventions reduce pain and improve outcomes. Cancer patients in medically underserved areas receive limite ... Full text Link to item Cite

Preface

Book · January 1, 2021 Cite

Common Issues in Breast Cancer Survivors: A Practical Guide to Evaluation and Management

Book · January 1, 2021 This book provides a clinically useful resource for evaluation and management of the symptoms and issues that burden survivors of breast cancer. Improvements to breast cancer screening and treatment have resulted in more patients than ever before having be ... Full text Cite

Overview of the National and International Guidelines for Care of Breast Cancer Survivors

Chapter · January 1, 2021 Medical management guidelines provide lifelines for busy clinicians trying to determine the best approach for individual patient scenarios. By identifying, collating, reviewing, and categorizing published results, guidelines save time and provide valuable ... Full text Cite

Improving health engagement and lifestyle management for breast cancer survivors with diabetes.

Journal Article Contemp Clin Trials · May 2020 Breast cancer survivors with type 2 diabetes are at high risk for cancer recurrence, serious health complications, more severe symptoms, psychological distress, and premature death relative to breast cancer survivors without diabetes. Maintaining glycemic ... Full text Open Access Link to item Cite

The need for a Serious Illness Digital Ecosystem (SIDE) to improve outcomes for patients receiving palliative and hospice care.

Journal Article Am J Manag Care · April 2020 Palliative and hospice care services produce immense benefits for patients living with serious illness and for their families. Due to the national shift toward value-based payment models, health systems and payers share a heightened awareness of the need t ... Full text Open Access Link to item Cite

Coping Skills Training and Acceptance and Commitment Therapy for Symptom Management: Feasibility and Acceptability of a Brief Telephone-Delivered Protocol for Patients With Advanced Cancer.

Journal Article J Pain Symptom Manage · February 2020 CONTEXT: Patients with advanced cancer face a life-limiting condition that brings a high symptom burden that often includes pain, fatigue, and psychological distress. Psychosocial interventions have promise for managing symptoms but need additional tailori ... Full text Link to item Cite

Randomized Trial of Standard Adjuvant Chemotherapy Regimens Versus Capecitabine in Older Women With Early Breast Cancer: 10-Year Update of the CALGB 49907 Trial.

Journal Article J Clin Oncol · September 10, 2019 PURPOSE: Older women with breast cancer remain under-represented in clinical trials. The Cancer and Leukemia Group B 49907 trial focused on women age 65 years and older. We previously reported the primary analysis after a median follow-up of 2.4 years. Sta ... Full text Link to item Cite

Testing a behavioral intervention to improve adherence to adjuvant endocrine therapy (AET).

Journal Article Contemp Clin Trials · January 2019 Adjuvant endocrine therapy (AET) is used to prevent recurrence and reduce mortality for women with hormone receptor positive breast cancer. Poor adherence to AET is a significant problem and contributes to increased medical costs and mortality. A variety o ... Full text Open Access Link to item Cite

Development and pilot testing of an mHealth behavioral cancer pain protocol for medically underserved communities.

Journal Article J Psychosoc Oncol · 2019 The purpose of this study was to refine and test a mobile-health behavioral cancer pain coping skills training protocol for women with breast cancer and pain from medically underserved areas. Three focus groups (Phase 1) were used to refine the initial pro ... Full text Link to item Cite

A smoking cessation and pain management program for cancer survivors.

Journal Article J Cancer Surviv · December 2018 PURPOSE: Many cancer survivors continue to smoke. Further, most survivors also report high levels of persistent pain and smoke in response to pain. The investigators tested the feasibility, acceptability, and preliminary efficacy of a smoking cessation pro ... Full text Link to item Cite

The preference to receive chemotherapy and cancer-related outcomes in older adults with breast cancer CALGB 49907 (Alliance).

Journal Article J Geriatr Oncol · May 2018 OBJECTIVE: Chemotherapy preference refers to a patient's interest in receiving chemotherapy. This study examined whether chemotherapy preference was associated with toxicity, efficacy, quality of life (QoL), and functional outcomes during and after complet ... Full text Link to item Cite

NCCN Guidelines Insights: Palliative Care, Version 2.2017.

Journal Article J Natl Compr Canc Netw · August 2017 The NCCN Guidelines for Palliative Care provide interdisciplinary recommendations on palliative care for patients with cancer. These NCCN Guidelines Insights summarize and provide context for the updated guidelines recommendations regarding hospice and end ... Full text Link to item Cite

Palliative Care Version 1.2016.

Journal Article J Natl Compr Canc Netw · January 2016 The NCCN Guidelines for Palliative Care provide interdisciplinary recommendations on palliative care for patients with cancer. The NCCN Guidelines are intended to provide guidance to the primary oncology team on the integration of palliative care into onco ... Full text Link to item Cite

CHAMBER: A Regional Performance Improvement CME Initiative for Breast Cancer Health Care Providers.

Journal Article J Natl Compr Canc Netw · August 2015 CHAMBER was a regional educational initiative for providers of care to patients with HER2+ breast cancer. The study goals were to (1) enhance testing for HER2/neu overexpression in patients with invasive breast cancer; (2) increase the appropriate use of t ... Full text Link to item Cite

Palliative care, Version 1.2014. Featured updates to the NCCN Guidelines.

Journal Article J Natl Compr Canc Netw · October 2014 The NCCN Guidelines for Palliative Care provide interdisciplinary recommendations on palliative care for patients with cancer. These NCCN Guidelines Insights summarize the NCCN panel's discussions and guideline updates from 2013 and 2014. These include mod ... Full text Link to item Cite

Development of a virtual multidisciplinary lung cancer tumor board in a community setting.

Journal Article J Oncol Pract · May 2013 PURPOSE: Creating an effective platform for multidisciplinary tumor conferences can be challenging in the rural community setting. The Duke Cancer Network created an Internet-based platform for a multidisciplinary conference to enhance the care of patients ... Full text Link to item Cite

Palliative care.

Journal Article J Natl Compr Canc Netw · October 1, 2012 These guidelines were developed and updated by an interdisciplinary group of experts based on clinical experience and available scientific evidence. The goal of these guidelines is to help patients with cancer experience the best quality of life possible t ... Full text Link to item Cite

A phase II trial of bevacizumab plus everolimus for patients with refractory metastatic colorectal cancer.

Journal Article Oncologist · 2011 PURPOSE: For patients with metastatic colorectal cancer (mCRC), no standard therapy exists after progression on 5-fluorouracil, oxaliplatin, irinotecan, bevacizumab, and cetuximab or panitumumab. Preclinical data demonstrated that combined vascular endothe ... Full text Link to item Cite

Caregiver-assisted coping skills training for lung cancer: results of a randomized clinical trial.

Journal Article J Pain Symptom Manage · January 2011 CONTEXT: Lung cancer is one of the most common cancers in the United States and is associated with high levels of symptoms, including pain, fatigue, shortness of breath, and psychological distress. Caregivers and patients are adversely affected. However, p ... Full text Link to item Cite

"Short course" bortezomib plus melphalan and prednisone as induction prior to transplant or as frontline therapy for nontransplant candidates in patients with previously untreated multiple myeloma.

Journal Article Biol Blood Marrow Transplant · January 2010 The purpose of this study was to evaluate the efficacy and safety of short-course bortezomib, melphalan, prednisone (VMP) in previously untreated multiple myeloma as frontline therapy for transplant-ineligible patients and induction prior to autologous ste ... Full text Link to item Cite

Interleukin-6, multidrug resistance protein-1 expression and response to paclitaxel in women with metastatic breast cancer: results of cancer and leukemia group B trial 159806.

Journal Article Breast Cancer Res Treat · December 2006 Several reports have suggested that breast cancer patients with elevated serum levels of interleukin-6 (IL-6) have a worse prognosis than patients with lower levels. We have studied IL-6 in breast cancer cell lines and have shown that autocrine production ... Full text Link to item Cite

Palliative care. Clinical practice guidelines in oncology.

Journal Article J Natl Compr Canc Netw · September 2006 Full text Link to item Cite

Partner-guided cancer pain management at the end of life: a preliminary study.

Journal Article J Pain Symptom Manage · March 2005 This preliminary study tested the efficacy of a partner-guided cancer pain management protocol for patients who are at the end of life. Seventy-eight advanced cancer patients meeting criteria for hospice eligibility and their partners were randomly assigne ... Full text Link to item Cite

The self-efficacy of family caregivers for helping cancer patients manage pain at end-of-life.

Journal Article Pain · May 2003 This preliminary study examined the self-efficacy of family caregivers with regard to helping cancer patients manage pain at end of life. A sample of 63 family caregivers of hospice-eligible cancer patients with pain provided ratings of their self-efficacy ... Full text Link to item Cite

Management of terminal cancer in elderly patients.

Journal Article Lancet Oncol · March 2003 Advances in health care and changing demographics worldwide have led to an ageing population whose care at the end of life has become increasingly complicated. Clinicians face a difficult challenge in the effective management of symptoms and suffering of e ... Full text Link to item Cite

Multicenter phase II study of a 28-day regimen of orally administered eniluracil and fluorouracil in the treatment of patients with anthracycline- and taxane-resistant advanced breast cancer.

Journal Article J Clin Oncol · February 15, 2002 PURPOSE: Eniluracil (776C85), a potent inactivator of dihydropyrimidine dehydrogenase, allows fluorouracil (5-FU) to be administered orally on a schedule that simulates continuous-infusion 5-FU. The primary objective of this study was to estimate the objec ... Full text Link to item Cite

A review of hereditary breast cancer: from screening to risk factor modification.

Journal Article Am J Med · April 1997 The identification of genetic mutations thought to be directly responsible for the development of breast cancer represents a major advance in our understanding of this disease. Mutations in BRCA1 and BRCA2 are thought to be responsible for the majority of ... Full text Link to item Cite

Pharmacokinetics and clinical impact of all-trans retinoic acid in metastatic breast cancer: a phase II trial.

Journal Article Cancer Chemother Pharmacol · 1997 PURPOSE: The purpose of this trial was to evaluate tumor cytoreduction by all-trans retinoic acid (ATRA) in patients with metastatic breast cancer and to characterize the initial pharmacokinetics of this agent. METHODS: The study was a single institution, ... Full text Link to item Cite

Continuous infusion 5-fluorouracil as first-line therapy for metastatic breast cancer.

Journal Article J Infus Chemother · 1996 Previous phase II studies of continuous infusion Fluorouracil (5-FU) (CI 5-FU) in refractory metastatic breast cancer have shown modest activity with low toxicity. Its activity in a first-line setting has not been formally tested. Patients were eligible if ... Link to item Cite

Quality of life after bone marrow transplantation.

Journal Article Oncology (Williston Park) · January 1994 Allogeneic and autologous bone marrow transplantation are performed with increasing frequency for a variety of malignancies as well as certain nonmalignant disorders. Physical toxicities associated with treatment are often substantial. Patients may also ex ... Link to item Cite