Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., Johns Hopkins University 1990
• Recognition
• 

  In the News

  • SEP 16, 2022

    The Graduate School

    Suzanne Barbour Discusses Her Goals and Plans for the Graduate School

  • SEP 16, 2022

    Duke Office of Scientific Integrity

    The New Dean of the Graduate School on Research, Mentoring and How to Help Graduate Students
• Research
• 

  External Relationships

  • American Society for Biochemistry and Molecular Biology
  • Educational Testing Services
  • National Science Foundation
  • council of graduate schools
• Publications & Artistic Works
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  Selected Publications

  • Academic Articles

    • Ali, Tomader, Xiaoyong Lei, Suzanne E. Barbour, Akio Koizumi, Charles E. Chalfant, and Sasanka Ramanadham. “Alterations in β-Cell Sphingolipid Profile Associated with ER Stress and iPLA2β: Another Contributor to β-Cell Apoptosis in Type 1 Diabetes.” Molecules 26, no. 21 (October 21, 2021). https://doi.org/10.3390/molecules26216361.
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    • Nelson, Alexander J., Daniel J. Stephenson, Christopher L. Cardona, Xiaoyong Lei, Abdulaziz Almutairi, Tayleur D. White, Ying G. Tusing, et al. “Macrophage polarization is linked to Ca2+-independent phospholipase A2β-derived lipids and cross-cell signaling in mice.” J Lipid Res 61, no. 2 (February 2020): 143–58. https://doi.org/10.1194/jlr.RA119000281.
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    • Barbour, Suzanne E., Phuong T. Nguyen, Margaret Park, Bhargavi Emani, Xiaoyong Lei, Mamatha Kambalapalli, Jacqueline C. Shultz, Dayanjan Wijesinghe, Charles E. Chalfant, and Sasanka Ramanadham. “Group VIA Phospholipase A2 (iPLA2β) Modulates Bcl-x 5'-Splice Site Selection and Suppresses Anti-apoptotic Bcl-x(L) in β-Cells.” J Biol Chem 290, no. 17 (April 24, 2015): 11021–31. https://doi.org/10.1074/jbc.M115.648956.
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    • Lei, Xiaoyong, Sheng Zhang, Alan Bohrer, Suzanne E. Barbour, and Sasanka Ramanadham. “Role of calcium-independent phospholipase A(2)β in human pancreatic islet β-cell apoptosis.” Am J Physiol Endocrinol Metab 303, no. 11 (December 1, 2012): E1386–95. https://doi.org/10.1152/ajpendo.00234.2012.
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    • Mukherjee, Abir, Jinhua Wu, Suzanne Barbour, and Xianjun Fang. “Lysophosphatidic acid activates lipogenic pathways and de novo lipid synthesis in ovarian cancer cells.” J Biol Chem 287, no. 30 (July 20, 2012): 24990–0. https://doi.org/10.1074/jbc.M112.340083.
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    • Falanga, Yves T., Natalia S. Chaimowitz, Nicolas Charles, Fred D. Finkelman, Nicholas A. Pullen, Suzanne Barbour, Kevin Dholaria, et al. “Lyn but not Fyn kinase controls IgG-mediated systemic anaphylaxis.” J Immunol 188, no. 9 (May 1, 2012): 4360–68. https://doi.org/10.4049/jimmunol.1003223.
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    • Norton, S. K., D. S. Wijesinghe, A. Dellinger, J. Sturgill, Z. Zhou, S. Barbour, C. Chalfant, D. H. Conrad, and C. L. Kepley. “Epoxyeicosatrienoic acids are involved in the C70 fullerene derivative-induced control of allergic asthma.” Journal of Allergy and Clinical Immunology 130, no. 3 (January 1, 2012). https://doi.org/10.1016/j.jaci.2012.04.023.
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    • Kikuchi, T., M. M. El Shikh, R. M. El Sayed, D. B. Purkall, M. M. Elaasser, A. Sarraf, S. E. Barbour, H. A. Schenkein, and J. G. Tew. “Anti-phosphorylcholine-opsonized low-density lipoprotein promotes rapid production of proinflammatory cytokines by dendritic cells and natural killer cells.” J Periodontal Res 45, no. 6 (December 2010): 720–30. https://doi.org/10.1111/j.1600-0765.2010.01292.x.
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    • Lei, X., S. Zhang, B. Emani, S. E. Barbour, and S. Ramanadham. “A link between endoplasmic reticulum stress-induced β-cell apoptosis and the group VIA Ca2+-independent phospholipase A2 (iPLA2β).” Diabetes Obes Metab 12 Suppl 2, no. 0 2 (October 2010): 93–98. https://doi.org/10.1111/j.1463-1326.2010.01270.x.
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    • Griffiths, R., and S. Barbour. “Lipoproteins and lipoprotein metabolism in periodontal disease.” Clinical Lipidology 5, no. 3 (June 1, 2010): 397–411. https://doi.org/10.2217/clp.10.27.
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    • Lei, Xiaoyong, Suzanne E. Barbour, and Sasanka Ramanadham. “Group VIA Ca2+-independent phospholipase A2 (iPLA2beta) and its role in beta-cell programmed cell death.” Biochimie 92, no. 6 (June 2010): 627–37. https://doi.org/10.1016/j.biochi.2010.01.005.
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    • Lei, Xiaoyong, Sheng Zhang, Suzanne E. Barbour, Alan Bohrer, Eric L. Ford, Akio Koizumi, Feroz R. Papa, and Sasanka Ramanadham. “Spontaneous development of endoplasmic reticulum stress that can lead to diabetes mellitus is associated with higher calcium-independent phospholipase A2 expression: a role for regulation by SREBP-1.” J Biol Chem 285, no. 9 (February 26, 2010): 6693–6705. https://doi.org/10.1074/jbc.M109.084293.
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    • Ratz, Paul H., Amy S. Miner, and Suzanne E. Barbour. “Calcium-independent phospholipase A2 participates in KCl-induced calcium sensitization of vascular smooth muscle.” Cell Calcium 46, no. 1 (July 2009): 65–72. https://doi.org/10.1016/j.ceca.2009.05.001.
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    • Gude, David R., Sergio E. Alvarez, Steven W. Paugh, Poulami Mitra, JiaDe Yu, Rachael Griffiths, Suzanne E. Barbour, Sheldon Milstien, and Sarah Spiegel. “Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a "come-and-get-me" signal.” Faseb J 22, no. 8 (August 2008): 2629–38. https://doi.org/10.1096/fj.08-107169.
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    • Wilkins, W. P., and S. E. Barbour. “Group VI phospholipases A2: homeostatic phospholipases with significant potential as targets for novel therapeutics.” Curr Drug Targets 9, no. 8 (August 2008): 683–97. https://doi.org/10.2174/138945008785132385.
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    • Rufail, M. L., H. A. Schenkein, T. E. Koertge, A. M. Best, S. E. Barbour, J. G. Tew, and R. van Antwerpen. “Atherogenic lipoprotein parameters in patients with aggressive periodontitis.” J Periodontal Res 42, no. 6 (December 2007): 495–502. https://doi.org/10.1111/j.1600-0765.2007.00973.x.
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    • Song, Yuanda, Palmer Wilkins, Wenhui Hu, Karnam S. Murthy, Jing Chen, Zendra Lee, Regina Oyesanya, Jinhua Wu, Suzanne E. Barbour, and Xianjun Fang. “Inhibition of calcium-independent phospholipase A2 suppresses proliferation and tumorigenicity of ovarian carcinoma cells.” Biochem J 406, no. 3 (September 15, 2007): 427–36. https://doi.org/10.1042/BJ20070631.
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    • Shin, C. R., J. Moores, A. M. Best, J. G. Tew, H. A. Schenkein, and S. E. Barbour. “Differential platelet-activating factor synthesis by monocytes and polymorphonuclear leukocytes from subjects with localized aggressive periodontitis.” J Periodontal Res 42, no. 3 (June 2007): 202–11. https://doi.org/10.1111/j.1600-0765.2006.00933.x.
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    • Payne, Shawn G., Carole A. Oskeritzian, Rachael Griffiths, Preeti Subramanian, Suzanne E. Barbour, Charles E. Chalfant, Sheldon Milstien, and Sarah Spiegel. “The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors.” Blood 109, no. 3 (February 1, 2007): 1077–85. https://doi.org/10.1182/blood-2006-03-011437.
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    • Schenkein, Harvey A., Suzanne E. Barbour, and John G. Tew. “Cytokines and inflammatory factors regulating immunoglobulin production in aggressive periodontitis.” Periodontol 2000 45 (2007): 113–27. https://doi.org/10.1111/j.1600-0757.2007.00214.x.
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    • Tanaka, S., M. Fakher, S. E. Barbour, H. A. Schenkein, and J. G. Tew. “Influence of proinflammatory cytokines on Actinobacillus actinomycetemcomitans specific IgG responses.” J Periodontal Res 41, no. 1 (February 2006): 1–9. https://doi.org/10.1111/j.1600-0765.2005.00829.x.
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    • Rufail, Miguel L., Harvey A. Schenkein, Suzanne E. Barbour, John G. Tew, and Rik van Antwerpen. “Altered lipoprotein subclass distribution and PAF-AH activity in subjects with generalized aggressive periodontitis.” J Lipid Res 46, no. 12 (December 2005): 2752–60. https://doi.org/10.1194/jlr.M500389-JLR200.
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    • Kikuchi, T., D. L. Willis, M. Liu, D. B. Purkall, S. Sukumar, S. E. Barbour, H. A. Schenkein, and J. G. Tew. “Dendritic-NK cell interactions in P. gingivalis-specific responses.” J Dent Res 84, no. 9 (September 2005): 858–62. https://doi.org/10.1177/154405910508400915.
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    • Manguikian, Alex D., and Suzanne E. Barbour. “Cell cycle dependence of group VIA calcium-independent phospholipase A2 activity.” J Biol Chem 279, no. 51 (December 17, 2004): 52881–92. https://doi.org/10.1074/jbc.M410659200.
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    • Payne, Shawn G., Sheldon Milstien, Suzanne E. Barbour, and Sarah Spiegel. “Modulation of adaptive immune responses by sphingosine-1-phosphate.” Semin Cell Dev Biol 15, no. 5 (October 2004): 521–27. https://doi.org/10.1016/j.semcdb.2004.05.008.
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    • Kikuchi, T., C. L. Hahn, S. Tanaka, S. E. Barbour, H. A. Schenkein, and J. G. Tew. “Dendritic cells stimulated with Actinobacillus actinomycetemcomitans elicit rapid gamma interferon responses by natural killer cells.” Infect Immun 72, no. 9 (September 2004): 5089–96. https://doi.org/10.1128/IAI.72.9.5089-5096.2004.
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    • Seashols, Sarah J., Antonio del Castillo Olivares, Gregorio Gil, and Suzanne E. Barbour. “Regulation of group VIA phospholipase A2 expression by sterol availability.” Biochim Biophys Acta 1684, no. 1–3 (August 30, 2004): 29–37. https://doi.org/10.1016/j.bbalip.2004.05.003.
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    • Al-Darmaki, Salma, Kandi Knightshead, Yuichi Ishihara, Al Best, Harvey A. Schenkein, John G. Tew, and Suzanne E. Barbour. “Delineation of the role of platelet-activating factor in the immunoglobulin G2 antibody response.” Clin Diagn Lab Immunol 11, no. 4 (July 2004): 720–28. https://doi.org/10.1128/CDLI.11.4.720-728.2004.
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    • Paugh, Steven W., Shawn G. Payne, Suzanne E. Barbour, Sheldon Milstien, and Sarah Spiegel. “The immunosuppressant FTY720 is phosphorylated by sphingosine kinase type 2.” Febs Lett 554, no. 1–2 (November 6, 2003): 189–93. https://doi.org/10.1016/s0014-5793(03)01168-2.
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    • Schenkein, H. A., C. R. Berry, J. A. Burmeister, C. N. Brooks, S. E. Barbour, A. M. Best, and J. G. Tew. “Anti-cardiolipin antibodies in sera from patients with periodontitis.” J Dent Res 82, no. 11 (November 2003): 919–22. https://doi.org/10.1177/154405910308201114.
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    • Tanaka, Shigehisa, Suzanne E. Barbour, Al M. Best, Harvey A. Schenkein, and John G. Tew. “Prostaglandin E2-mediated regulation of immunoglobulin G2 via interferon gamma.” J Periodontol 74, no. 6 (June 2003): 771–79. https://doi.org/10.1902/jop.2003.74.6.771.
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    • Al-Darmaki, Salma, Harvey A. Schenkein, John G. Tew, and Suzanne E. Barbour. “Differential expression of platelet-activating factor acetylhydrolase in macrophages and monocyte-derived dendritic cells.” J Immunol 170, no. 1 (January 1, 2003): 167–73. https://doi.org/10.4049/jimmunol.170.1.167.
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    • Barbour, Suzanne E., Yuichi Ishihara, Mohammed Fakher, Salma Al-Darmaki, Timothy H. Caven, C. P. Shelburne, Al M. Best, Harvey A. Schenkein, and John G. Tew. “Monocyte differentiation in localized juvenile periodontitis is skewed toward the dendritic cell phenotype.” Infect Immun 70, no. 6 (June 2002): 2780–86. https://doi.org/10.1128/IAI.70.6.2780-2786.2002.
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    • Baez, Juan M., Suzanne E. Barbour, and David E. Cohen. “Phosphatidylcholine transfer protein promotes apolipoprotein A-I-mediated lipid efflux in Chinese hamster ovary cells.” J Biol Chem 277, no. 8 (February 22, 2002): 6198–6206. https://doi.org/10.1074/jbc.M106799200.
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    • Ishihara, Y., J. B. Zhang, M. Fakher, A. M. Best, H. A. Schenkein, S. E. Barbour, and J. G. Tew. “Non-redundant roles for interleukin-1 alpha and interleukin-1 beta in regulating human IgG2.” J Periodontol 72, no. 10 (October 2001): 1332–39. https://doi.org/10.1902/jop.2001.72.10.1332.
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    • Barbour, S. E., and F. Marciano-Cabral. “Naegleria fowleri amoebae express a membrane-associated calcium-independent phospholipase A(2).” Biochim Biophys Acta 1530, no. 2–3 (February 26, 2001): 123–33. https://doi.org/10.1016/s1388-1981(00)00069-x.
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    • Schenkein, H. A., S. E. Barbour, C. R. Berry, B. Kipps, and J. G. Tew. “Invasion of human vascular endothelial cells by Actinobacillus actinomycetemcomitans via the receptor for platelet-activating factor.” Infect Immun 68, no. 9 (September 2000): 5416–19. https://doi.org/10.1128/IAI.68.9.5416-5419.2000.
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    • Ishihara, Y., J. B. Zhang, S. M. Quinn, H. A. Schenkein, A. M. Best, S. E. Barbour, and J. G. Tew. “Regulation of immunoglobulin G2 production by prostaglandin E(2) and platelet-activating factor.” Infect Immun 68, no. 3 (March 2000): 1563–68. https://doi.org/10.1128/IAI.68.3.1563-1568.2000.
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    • Barbour, S. E., A. Kapur, and C. L. Deal. “Regulation of phosphatidylcholine homeostasis by calcium-independent phospholipase A2.” Biochim Biophys Acta 1439, no. 1 (July 9, 1999): 77–88. https://doi.org/10.1016/s1388-1981(99)00078-5.
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    • Kapur, A., and S. E. Barbour. “Induction of phosphatidylcholine synthesis in cho cells by sPLA2.” Faseb Journal 12, no. 8 (December 1, 1998).
    • Barbour, S. E., C. Wong, D. Rabah, A. Kapur, and A. D. Carter. “Mature macrophage cell lines exhibit variable responses to LPS.” Mol Immunol 35, no. 14–15 (October 1998): 977–87. https://doi.org/10.1016/s0161-5890(98)00070-4.
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    • Jarvis, W. D., F. A. Fornari, K. L. Auer, A. J. Freemerman, E. Szabo, M. J. Birrer, C. R. Johnson, S. E. Barbour, P. Dent, and S. Grant. “Coordinate regulation of stress- and mitogen-activated protein kinases in the apoptotic actions of ceramide and sphingosine.” Mol Pharmacol 52, no. 6 (December 1997): 935–47. https://doi.org/10.1124/mol.52.6.935.
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    • Balsinde, J., S. E. Barbour, I. D. Bianco, and E. A. Dennis. “Arachidonic acid mobilization in P388D1 macrophages is controlled by two distinct Ca(2+)-dependent phospholipase A2 enzymes.” Proc Natl Acad Sci U S A 91, no. 23 (November 8, 1994): 11060–64. https://doi.org/10.1073/pnas.91.23.11060.
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    • Barbour, S. E., and E. A. Dennis. “Antisense inhibition of group II phospholipase A2 expression blocks the production of prostaglandin E2 by P388D1 cells.” J Biol Chem 268, no. 29 (October 15, 1993): 21875–82.
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    • Barbour, S., M. Edidin, B. Felding-Habermann, J. Taylor-Norton, N. S. Radin, and B. A. Fenderson. “Glycolipid depletion using a ceramide analogue (PDMP) alters growth, adhesion, and membrane lipid organization in human A431 cells.” J Cell Physiol 150, no. 3 (March 1992): 610–19. https://doi.org/10.1002/jcp.1041500322.
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    • Barbour, S., and M. Edidin. “Cell-specific constraints to the lateral diffusion of a membrane glycoprotein.” J Cell Physiol 150, no. 3 (March 1992): 526–33. https://doi.org/10.1002/jcp.1041500313.
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    • Imagawa, D. K., S. E. Barbour, B. P. Morgan, T. M. Wright, H. S. Shin, and L. E. Ramm. “Role of complement C9 and calcium in the generation of arachidonic acid and its metabolites from rat polymorphonuclear leukocytes.” Mol Immunol 24, no. 12 (December 1987): 1263–71. https://doi.org/10.1016/0161-5890(87)90120-9.
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  • Book Sections

    • Barbour, S. E., and S. Ramanadham. “Analyses of Calcium-Independent Phospholipase A2beta (iPLA2β) in Biological Systems.,” 583:119–41, 2017. https://doi.org/10.1016/bs.mie.2016.09.001.
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