Current Appointments & Affiliations
Dean of The Graduate School and Vice Provost for Graduate Education
·
2022 - Present
Graduate School
Professor of Cell Biology
·
2023 - Present
Cell Biology,
Basic Science Departments
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Recent Publications
Alterations in β-Cell Sphingolipid Profile Associated with ER Stress and iPLA2β: Another Contributor to β-Cell Apoptosis in Type 1 Diabetes.
Journal Article Molecules · October 21, 2021 Type 1 diabetes (T1D) development, in part, is due to ER stress-induced β-cell apoptosis. Activation of the Ca2+-independent phospholipase A2 beta (iPLA2β) leads to the generation of pro-inflammatory eicosanoids, which contribute to β-cell death and T1D. E ... Full text Open Access Link to item CiteMacrophage polarization is linked to Ca2+-independent phospholipase A2β-derived lipids and cross-cell signaling in mice.
Journal Article J Lipid Res · February 2020 Phospholipases A2 (PLA2s) catalyze hydrolysis of the sn-2 substituent from glycerophospholipids to yield a free fatty acid (i.e., arachidonic acid), which can be metabolized to pro- or anti-inflammatory eicosanoids. Macrophages modulate inflammatory respon ... Full text Link to item CiteAnalyses of Calcium-Independent Phospholipase A2beta (iPLA2β) in Biological Systems.
Chapter · 2017 The Ca2+-independent phospholipases A2 (iPLA2s) are part of a diverse family of PLA2s, manifest activity in the absence of Ca2+, are ubiquitous, and participate in a variety of biological processes. Among the iPLA2s, the cytosolic iPLA2β has received consi ... Full text Link to item CiteRecent Grants
Elevating Duke's Excellence in Interdisciplinary Research and Scholarship: An Adaptable Framework for Interdisciplinary Ph.D. Training Programs
Inst. Training Prgm or CMEPrincipal Investigator · Awarded by Duke Endowment · 2024 - 2031Nurse LEADS: Training in Nurse-LEd models of care ADdressing the Social Determinants of Health
Inst. Training Prgm or CMEAdvisor · Awarded by National Institutes of Health · 2024 - 2029Sloan Foundation Grant
Inst. Training Prgm or CMEPrincipal Investigator · Awarded by Alfred P. Sloan Foundation · 2024 - 2027View All Grants
Education, Training & Certifications
Johns Hopkins University ·
1990
Ph.D.