Xiaoying Shen
Associate Professor in Surgery
Dr. Shen is an Associate Director and Deputy of the Laboratory for HIV and COVID-19 Vaccine Research & Development in the Department of Surgery, Division of Surgical Sciences at Duke University Medical Center. Her research interest focuses on the humoral immune response following virus infection or vaccination. During the past decade, she has worked intensively on the specificity and breadth of binding antibody responses against HIV.
Dr. Shen’s team developed assays and analytical tools for a peptide microarray assay for finely mapping of HIV-1 cross-subtype linear epitopes targeted by antibody responses in human specimens as well as animal models, and adopted a multiplex binding antibody assay for evaluating binding antibody responses. With these technologies, her team evaluated various clinical HIV-1 vaccine studies and NHP studies. Building upon the data generated by her team and other collaborators, Dr. Shen works with bioinformatics and biostatistics personnel on deciphering immune correlates in both human clinical trials and nonhuman primate studies. During the COVID-19 pandemic, her team expanded their research to SARS-COV-2 antibody responses.
In 2021, Dr. Shen became the Deputy Director of the Laboratory for HIV and COVID-19 Vaccine Research & Development, alongside Laboratory Director Dr. Montefiori. The laboratory established a lentivirus-based pseudovirus SARS-CoV-2 neutralization assay that has been FDA-approved. The laboratory is assessing neutralizing antibody responses for multiple phase 3 COVID-19 vaccine trials. In addition to supporting clinical trials, the lab has a strong focus on characterizing SARS-CoV-2 variants for their neutralizing susceptibility and potential to escape from vaccine-elicited immune responses.
Meanwhile, Dr. Shen’s team remains highly active in HIV-1 vaccine research, evaluating neutralizing responses in preclinical and clinical HIV vaccine trials as a core laboratory for multiple networks including the HIV Vaccine Trials Network (HVTN), the Collaboration for AIDS Vaccine Discovery (CAVD) funded by Bill & Melinda Gates Foundation, as well as the NIH Nonhuman Primate Core Humoral Immunology Laboratory for AIDS Vaccine which Dr. Shen directs.
Current Appointments & Affiliations
- Associate Professor in Surgery, Surgery, Surgical Sciences, Surgery 2021
- Member of the Duke Human Vaccine Institute, Duke Human Vaccine Institute, Institutes and Centers 2007
Contact Information
- 205 Sorf, 915 S. Lasalle Street, Box 2926, Duke University Medical Center, Durham, NC 27710
- Box 2926 DUMC, Durham, NC 27710
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sxshen@duke.edu
(919) 684-9986
- Background
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Education, Training, & Certifications
- Ph.D., University of California - Davis 2004
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Previous Appointments & Affiliations
- Associate Professor in Surgery, Surgery, Surgical Sciences, Surgery 2020
- Assistant Professor in Surgery, Surgery, Surgical Sciences, Surgery 2019 - 2020
- Assistant Professor in Medicine, Medicine, Duke Human Vaccine Institute, Medicine 2016 - 2019
- Medical Instructor in the Department of Medicine, Medicine, Duke Human Vaccine Institute, Medicine 2011 - 2016
- Research
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Selected Grants
- Moderna mRNA1275 P205 Trial Neutralizing Antibody Assessment awarded by Moderna Therapeutics, Inc. 2021 - 2024
- A Phase 2/3, Two-Part, Open-Label, Dose-Escalation, Age De-escalation and Randomized, Observer-Blind, Placebo-Controlled, Expansion Study to Evaluate the Safety, Tolerability, Reactogenicity, and Effe awarded by Moderna Therapeutics, Inc. 2021 - 2024
- CIVICs A - Option 18C awarded by National Institutes of Health 2022 - 2023
- A Phase 1, Randomized, Observer-Blind, Dose-Ranging Study to Evaluate the Safety, Reactogenicity, and Immunogenicity of mRNA-1283 and mRNA-1273 SARS-CoV-2 Vaccine in Adults Aged 18-55 Years awarded by Moderna Therapeutics, Inc. 2021 - 2023
- CIVICs A - Option 18B SAVE Aim 3 awarded by National Institute of Allergy and Infectious Diseases 2021 - 2023
- A Phase 3b, Open-Label, Safety and Immunogenicity Study of SARS-CoV-2 mRNA-1273 Vaccine in Adult Solid Organ Transplant Recipients and Healthy Controls awarded by Moderna Therapeutics, Inc. 2021 - 2023
- Neutralizing Antibody Response Assessment for a Phase 2/3 Randomized, Observer-Blind, Placebo-Controlled, Study to Evaluate the Safety, Reactogenicity, and Effectiveness of mRNA-1273 SARS-CoV-2 Vaccin awarded by Moderna Therapeutics, Inc. 2021 - 2023
- Nonhuman Primate Option 18 awarded by National Institutes of Health 2022 - 2023
- GH-VAP: Duke Antibody Dynamics Core Extension; INV-008612 Supplement awarded by Bill and Melinda Gates Foundation 2019 - 2022
- Characterizing the Neutralizing Antibody Response in SARS-CoV-2 Infected Individuals awarded by Rush University Medical Center 2020 - 2022
- A PHASE 2a, RANDOMIZED, OBSERVER-BLIND, PLACEBO-CONTROLLED, DOSE-CONFIRMATION STUDY TO EVALUATE THE SAFETY, REACTOGENICITY, AND IMMUNOGENICITY OF MRNA-1273 SARS-COV-2 VACCINE IN ADULTS AGED 18 YEARS A awarded by Moderna Therapeutics, Inc. 2021 - 2022
- CIVICs A - Option 18A SAVE Aims 1, 2 awarded by National Institute of Allergy and Infectious Diseases 2021 - 2022
- CoVPN 5001 A prospective study of acute immune responses to SARS-CoV2 infection - LAB awarded by Fred Hutchinson Cancer Research Center 2020 - 2022
- Sublingual-parenteral vaccination to prevent oral HIV transmission in infants awarded by University of North Carolina - Chapel Hill 2018 - 2021
- Harnessing Mucin-IgG Interactions to Enhance HIV Vaccine Function awarded by Northwestern University 2020 - 2021
- Comparing HIV Mucosal Targets in US and Kenyan Populations awarded by Northwestern University 2019 - 2021
- Primate Contract Expansion for Covid-19 awarded by National Institutes of Health 2020 - 2021
- HVTN Laboratory Center: HVTN Phase 1 awarded by Fred Hutchinson Cancer Research Center 2015 - 2020
- Nonhuman Primate Option 22 awarded by National Institutes of Health 2018 - 2020
- Antibody and viral determinants of protection against CMV infection in the gB/MF59 vaccination cohort awarded by National Institutes of Health 2017 - 2020
- HVTN Laboratory Center: HVTN 117 awarded by Fred Hutchinson Cancer Research Center 2017 - 2018
- HVTN Laboratory Center: HVTN 118 awarded by Fred Hutchinson Cancer Research Center 2017 - 2018
- HIV Vaccine Trials Network: LC P5 PF awarded by Fred Hutchinson Cancer Research Center 2015 - 2018
- HVTN - A004 awarded by Fred Hutchinson Cancer Research Center 2015 - 2018
- Nonhuman Primate Core-Option 6 awarded by National Institutes of Health 2012 - 2018
- HIV Vaccine Trials Network: LC P5 PF awarded by Fred Hutchinson Cancer Research Center 2014 - 2015
- HVTN 505 Protocol awarded by Fred Hutchinson Cancer Research Center 2014 - 2015
- LC: HIV Vaccine Trials Network: Phase 1 PF awarded by Fred Hutchinson Cancer Research Center 2014 - 2015
- Enhancing protective antibody responses for a GM-CSF adjuvanted HIV vaccine awarded by GeoVax Inc 2014 - 2015
- Testing the ability of antibody-mucin interactions to provide vaccine function awarded by Northwestern University 2013 - 2015
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Xu, Shiwei, Margaret C. Carpenter, Rachel L. Spreng, Scott D. Neidich, Sharanya Sarkar, DeAnna Tenney, Derrick Goodman, et al. “Impact of adjuvants on the biophysical and functional characteristics of HIV vaccine-elicited antibodies in humans.” Npj Vaccines 7, no. 1 (August 4, 2022): 90. https://doi.org/10.1038/s41541-022-00514-9.Full Text Link to Item
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DeGrace, Marciela M., Elodie Ghedin, Matthew B. Frieman, Florian Krammer, Alba Grifoni, Arghavan Alisoltani, Galit Alter, et al. “Defining the risk of SARS-CoV-2 variants on immune protection.” Nature 605, no. 7911 (May 2022): 640–52. https://doi.org/10.1038/s41586-022-04690-5.Full Text Link to Item
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Welbourn, Sarah, Srirupa Chakraborty, Jie E. Yang, Anne S. Gleinich, Sailaja Gangadhara, Salar Khan, Courtney Ferrebee, et al. “A neutralizing antibody target in early HIV-1 infection was recapitulated in rhesus macaques immunized with the transmitted/founder envelope sequence.” Plos Pathog 18, no. 5 (May 2022): e1010488. https://doi.org/10.1371/journal.ppat.1010488.Full Text Link to Item
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Gay, Cynthia L., Katherine S. James, Marina Tuyishime, Shane D. Falcinelli, Sarah B. Joseph, Matthew J. Moeser, Brigitte Allard, et al. “Stable Latent HIV Infection and Low-level Viremia Despite Treatment With the Broadly Neutralizing Antibody VRC07-523LS and the Latency Reversal Agent Vorinostat.” J Infect Dis 225, no. 5 (March 2, 2022): 856–61. https://doi.org/10.1093/infdis/jiab487.Full Text Link to Item
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Sahoo, Anusmita, Edgar A. Hodge, Celia C. LaBranche, Tiffany M. Styles, Xiaoying Shen, Narayanaiah Cheedarla, Ayalnesh Shiferaw, et al. “Structure-guided changes at the V2 apex of HIV-1 clade C trimer enhance elicitation of autologous neutralizing and broad V1V2-scaffold antibodies.” Cell Rep 38, no. 9 (March 1, 2022): 110436. https://doi.org/10.1016/j.celrep.2022.110436.Full Text Link to Item
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Shen, Xiaoying. “Boosting immunity to Omicron.” Nat Med 28, no. 3 (March 2022): 445–46. https://doi.org/10.1038/s41591-022-01727-0.Full Text Link to Item
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Goldblatt, David, Andrew Fiore-Gartland, Marina Johnson, Adam Hunt, Christopher Bengt, Dace Zavadska, Hilda Darta Snipe, et al. “Towards a population-based threshold of protection for COVID-19 vaccines.” Vaccine 40, no. 2 (January 21, 2022): 306–15. https://doi.org/10.1016/j.vaccine.2021.12.006.Full Text Link to Item
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Saunders, Kevin O., Norbert Pardi, Robert Parks, Sampa Santra, Zekun Mu, Laura Sutherland, Richard Scearce, et al. “Author Correction: Lipid nanoparticle encapsulated nucleoside-modified mRNA vaccines elicit polyfunctional HIV-1 antibodies comparable to proteins in nonhuman primates.” Npj Vaccines 6, no. 1 (November 6, 2021): 136. https://doi.org/10.1038/s41541-021-00397-2.Full Text Link to Item
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Pino, Maria, Talha Abid, Susan Pereira Ribeiro, Venkata Viswanadh Edara, Katharine Floyd, Justin C. Smith, Muhammad Bilal Latif, et al. “A yeast expressed RBD-based SARS-CoV-2 vaccine formulated with 3M-052-alum adjuvant promotes protective efficacy in non-human primates.” Sci Immunol 6, no. 61 (July 15, 2021). https://doi.org/10.1126/sciimmunol.abh3634.Full Text Link to Item
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Cai, Fangping, Wei-Hung Chen, Weimin Wu, Julia A. Jones, Misook Choe, Neelakshi Gohain, Xiaoying Shen, et al. “Structural and genetic convergence of HIV-1 neutralizing antibodies in vaccinated non-human primates.” Plos Pathog 17, no. 6 (June 2021): e1009624. https://doi.org/10.1371/journal.ppat.1009624.Full Text Link to Item
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Shen, Xiaoying, Haili Tang, Rolando Pajon, Gale Smith, Gregory M. Glenn, Wei Shi, Bette Korber, and David C. Montefiori. “Neutralization of SARS-CoV-2 Variants B.1.429 and B.1.351.” The New England Journal of Medicine 384, no. 24 (June 2021): 2352–54. https://doi.org/10.1056/nejmc2103740.Full Text
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Seaton, Kelly E., Aaron Deal, Xue Han, Shuying S. Li, Ashley Clayton, Jack Heptinstall, Ann Duerr, et al. “Meta-analysis of HIV-1 vaccine elicited mucosal antibodies in humans.” Npj Vaccines 6, no. 1 (April 15, 2021): 56. https://doi.org/10.1038/s41541-021-00305-8.Full Text Link to Item
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Shen, Xiaoying, Haili Tang, Charlene McDanal, Kshitij Wagh, William Fischer, James Theiler, Hyejin Yoon, et al. “SARS-CoV-2 variant B.1.1.7 is susceptible to neutralizing antibodies elicited by ancestral spike vaccines.” Cell Host Microbe 29, no. 4 (April 14, 2021): 529-539.e3. https://doi.org/10.1016/j.chom.2021.03.002.Full Text Link to Item
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Saunders, Kevin O., Norbert Pardi, Robert Parks, Sampa Santra, Zekun Mu, Laura Sutherland, Richard Scearce, et al. “Lipid nanoparticle encapsulated nucleoside-modified mRNA vaccines elicit polyfunctional HIV-1 antibodies comparable to proteins in nonhuman primates.” Npj Vaccines 6, no. 1 (April 9, 2021): 50. https://doi.org/10.1038/s41541-021-00307-6.Full Text Link to Item
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Silva de Castro, Isabela, Giacomo Gorini, Rosemarie Mason, Jason Gorman, Massimiliano Bissa, Mohammad A. Rahman, Anush Arakelyan, et al. “Anti-V2 antibodies virus vulnerability revealed by envelope V1 deletion in HIV vaccine candidates.” Iscience 24, no. 2 (February 19, 2021): 102047. https://doi.org/10.1016/j.isci.2021.102047.Full Text Link to Item
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Shen, Xiaoying, Haili Tang, Charlene McDanal, Kshitij Wagh, Will Fischer, James Theiler, Hyejin Yoon, et al. “SARS-CoV-2 variant B.1.1.7 is susceptible to neutralizing antibodies elicited by ancestral Spike vaccines.” Biorxiv, January 29, 2021. https://doi.org/10.1101/2021.01.27.428516.Full Text Link to Item
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Saunders, Kevin O., Norbert Pardi, Robert Parks, Sampa Santra, Zekun Mu, Laura Sutherland, Richard Scearce, et al. “Lipid nanoparticle encapsulated nucleoside-modified mRNA vaccines elicit polyfunctional HIV-1 antibodies comparable to proteins in nonhuman primates.” Biorxiv, December 31, 2020. https://doi.org/10.1101/2020.12.30.424745.Full Text Link to Item
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Blasi, Maria, Donatella Negri, Kevin O. Saunders, Erich J. Baker, Hannah Stadtler, Celia LaBranche, Benjamin Mildenberg, et al. “Immunogenicity, safety, and efficacy of sequential immunizations with an SIV-based IDLV expressing CH505 Envs.” Npj Vaccines 5, no. 1 (November 18, 2020): 107. https://doi.org/10.1038/s41541-020-00252-w.Full Text Link to Item
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Om, Kier, Dominic Paquin-Proulx, Maria Montero, Kristina Peachman, Xiaoying Shen, Lindsay Wieczorek, Zoltan Beck, et al. “Adjuvanted HIV-1 vaccine promotes antibody-dependent phagocytic responses and protects against heterologous SHIV challenge.” Plos Pathog 16, no. 9 (September 2020): e1008764. https://doi.org/10.1371/journal.ppat.1008764.Full Text Link to Item
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Chang, WL William, Jesse D. Deere, Hung T. Kieu, Luis D. Castillo, Kawthar Machmach, Xiaoying Shen, Georgia D. Tomaras, et al. “RhCMV serostatus and vaccine adjuvant impact immunogenicity of RhCMV/SIV vaccines.” Sci Rep 10, no. 1 (August 20, 2020): 14056. https://doi.org/10.1038/s41598-020-71075-x.Full Text Link to Item
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Felber, Barbara K., Zhongyan Lu, Xintao Hu, Antonio Valentin, Margherita Rosati, Christopher A. L. Remmel, Joshua A. Weiner, et al. “Co-immunization of DNA and Protein in the Same Anatomical Sites Induces Superior Protective Immune Responses against SHIV Challenge.” Cell Rep 31, no. 6 (May 12, 2020): 107624. https://doi.org/10.1016/j.celrep.2020.107624.Full Text Link to Item
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Gorini, Giacomo, Slim Fourati, Monica Vaccari, Mohammad Arif Rahman, Shari N. Gordon, Dallas R. Brown, Lynn Law, et al. “Engagement of monocytes, NK cells, and CD4+ Th1 cells by ALVAC-SIV vaccination results in a decreased risk of SIVmac251 vaginal acquisition.” Plos Pathog 16, no. 3 (March 2020): e1008377. https://doi.org/10.1371/journal.ppat.1008377.Full Text Link to Item
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Verma, Anil, Brian A. Schmidt, Sonny R. Elizaldi, Nancy K. Nguyen, Korey A. Walter, Zoltan Beck, Hung V. Trinh, et al. “Impact of Th1 CD4 Follicular Helper T Cell Skewing on Antibody Responses to an HIV-1 Vaccine in Rhesus Macaques.” J Virol 94, no. 6 (February 28, 2020). https://doi.org/10.1128/JVI.01737-19.Full Text Link to Item
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Schneider, Jeffrey R., Xiaoying Shen, Chiara Orlandi, Tinashe Nyanhete, Sheetal Sawant, Ann M. Carias, Archer D. Smith, et al. “A MUC16 IgG Binding Activity Selects for a Restricted Subset of IgG Enriched for Certain Simian Immunodeficiency Virus Epitope Specificities.” J Virol 94, no. 5 (February 14, 2020). https://doi.org/10.1128/JVI.01246-19.Full Text Link to Item
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Shen, Xiaoying, Fatima Laher, Zoe Moodie, Arthur S. McMillan, Rachel L. Spreng, Peter B. Gilbert, Ying Huang, et al. “HIV-1 Vaccine Sequences Impact V1V2 Antibody Responses: A Comparison of Two Poxvirus Prime gp120 Boost Vaccine Regimens.” Sci Rep 10, no. 1 (February 7, 2020): 2093. https://doi.org/10.1038/s41598-020-57491-z.Full Text Link to Item
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Han, Qifeng, Todd Bradley, Wilton B. Williams, Derek W. Cain, David C. Montefiori, Kevin O. Saunders, Robert J. Parks, et al. “Neonatal Rhesus Macaques Have Distinct Immune Cell Transcriptional Profiles following HIV Envelope Immunization.” Cell Rep 30, no. 5 (February 4, 2020): 1553-1569.e6. https://doi.org/10.1016/j.celrep.2019.12.091.Full Text Open Access Copy Link to Item
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Schifanella, Luca, Susan W. Barnett, Massimiliano Bissa, Veronica Galli, Melvin N. Doster, Monica Vaccari, Georgia D. Tomaras, et al. “ALVAC-HIV B/C candidate HIV vaccine efficacy dependent on neutralization profile of challenge virus and adjuvant dose and type.” Plos Pathog 15, no. 12 (December 2019): e1008121. https://doi.org/10.1371/journal.ppat.1008121.Full Text Link to Item
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Pinto, Dora, Craig Fenwick, Christophe Caillat, Chiara Silacci, Serafima Guseva, François Dehez, Christophe Chipot, et al. “Structural Basis for Broad HIV-1 Neutralization by the MPER-Specific Human Broadly Neutralizing Antibody LN01.” Cell Host Microbe 26, no. 5 (November 13, 2019): 623-637.e8. https://doi.org/10.1016/j.chom.2019.09.016.Full Text Link to Item
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Li, Shuying S., Peter B. Gilbert, Lindsay N. Carpp, Chul-Woo Pyo, Holly Janes, Youyi Fong, Xiaoying Shen, et al. “Fc Gamma Receptor Polymorphisms Modulated the Vaccine Effect on HIV-1 Risk in the HVTN 505 HIV Vaccine Trial.” J Virol 93, no. 21 (November 1, 2019). https://doi.org/10.1128/JVI.02041-18.Full Text Link to Item
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Neidich, Scott D., Youyi Fong, Shuying S. Li, Daniel E. Geraghty, Brian D. Williamson, William Chad Young, Derrick Goodman, et al. “Antibody Fc effector functions and IgG3 associate with decreased HIV-1 risk.” J Clin Invest 129, no. 11 (November 1, 2019): 4838–49. https://doi.org/10.1172/JCI126391.Full Text Link to Item
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Gray, Glenda E., Ying Huang, Nicole Grunenberg, Fatima Laher, Surita Roux, Erica Andersen-Nissen, Stephen C. De Rosa, et al. “Immune correlates of the Thai RV144 HIV vaccine regimen in South Africa.” Sci Transl Med 11, no. 510 (September 18, 2019). https://doi.org/10.1126/scitranslmed.aax1880.Full Text Link to Item
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Nelson, Ashley N., Ria Goswami, Maria Dennis, Joshua Tu, Riley J. Mangan, Pooja T. Saha, Derek W. Cain, et al. “Simian-Human Immunodeficiency Virus SHIV.CH505-Infected Infant and Adult Rhesus Macaques Exhibit Similar Env-Specific Antibody Kinetics, despite Distinct T-Follicular Helper and Germinal Center B Cell Landscapes.” J Virol 93, no. 15 (August 1, 2019). https://doi.org/10.1128/JVI.00168-19.Full Text Link to Item
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Han, Qifeng, Julia A. Jones, Nathan I. Nicely, Rachel K. Reed, Xiaoying Shen, Katayoun Mansouri, Mark Louder, et al. “Difficult-to-neutralize global HIV-1 isolates are neutralized by antibodies targeting open envelope conformations.” Nat Commun 10, no. 1 (July 1, 2019): 2898. https://doi.org/10.1038/s41467-019-10899-2.Full Text Link to Item
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Dennis, Maria, Joshua Eudailey, Justin Pollara, Arthur S. McMillan, Kenneth D. Cronin, Pooja T. Saha, Alan D. Curtis, et al. “Coadministration of CH31 Broadly Neutralizing Antibody Does Not Affect Development of Vaccine-Induced Anti-HIV-1 Envelope Antibody Responses in Infant Rhesus Macaques.” J Virol 93, no. 5 (March 1, 2019). https://doi.org/10.1128/JVI.01783-18.Full Text Link to Item
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Sui, Yongjun, George K. Lewis, Yichuan Wang, Kurt Berckmueller, Blake Frey, Amiran Dzutsev, Diego Vargas-Inchaustegui, et al. “Mucosal vaccine efficacy against intrarectal SHIV is independent of anti-Env antibody response.” J Clin Invest 129, no. 3 (March 1, 2019): 1314–28. https://doi.org/10.1172/JCI122110.Full Text Link to Item
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Jones, Andrew T., Xiaoying Shen, Korey L. Walter, Celia C. LaBranche, Linda S. Wyatt, Georgia D. Tomaras, David C. Montefiori, et al. “HIV-1 vaccination by needle-free oral injection induces strong mucosal immunity and protects against SHIV challenge.” Nat Commun 10, no. 1 (February 18, 2019): 798. https://doi.org/10.1038/s41467-019-08739-4.Full Text Link to Item
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Phillips, Bonnie, Koen K. A. Van Rompay, Jennifer Rodriguez-Nieves, Clarisse Lorin, Marguerite Koutsoukos, Mark Tomai, Christopher B. Fox, et al. “Adjuvant-Dependent Enhancement of HIV Env-Specific Antibody Responses in Infant Rhesus Macaques.” J Virol 92, no. 20 (October 15, 2018). https://doi.org/10.1128/JVI.01051-18.Full Text Link to Item
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Mendoza, Pilar, Henning Gruell, Lilian Nogueira, Joy A. Pai, Allison L. Butler, Katrina Millard, Clara Lehmann, et al. “Combination therapy with anti-HIV-1 antibodies maintains viral suppression.” Nature 561, no. 7724 (September 2018): 479–84. https://doi.org/10.1038/s41586-018-0531-2.Full Text Link to Item
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Singh, Shakti, Eric G. Ramírez-Salazar, Rami Doueiri, Antonio Valentin, Margherita Rosati, Xintao Hu, Brandon F. Keele, et al. “Control of Heterologous Simian Immunodeficiency Virus SIVsmE660 Infection by DNA and Protein Coimmunization Regimens Combined with Different Toll-Like-Receptor-4-Based Adjuvants in Macaques.” J Virol 92, no. 15 (August 1, 2018). https://doi.org/10.1128/JVI.00281-18.Full Text Link to Item
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Vaccari, Monica, Slim Fourati, Shari N. Gordon, Dallas R. Brown, Massimilano Bissa, Luca Schifanella, Isabela Silva de Castro, et al. “HIV vaccine candidate activation of hypoxia and the inflammasome in CD14+ monocytes is associated with a decreased risk of SIVmac251 acquisition.” Nat Med 24, no. 6 (June 2018): 847–56. https://doi.org/10.1038/s41591-018-0025-7.Full Text Link to Item
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Schiffner, Torben, Jesper Pallesen, Rebecca A. Russell, Jonathan Dodd, Natalia de Val, Celia C. LaBranche, David Montefiori, et al. “Structural and immunologic correlates of chemically stabilized HIV-1 envelope glycoproteins.” Plos Pathog 14, no. 5 (May 2018): e1006986. https://doi.org/10.1371/journal.ppat.1006986.Full Text Link to Item
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Yates, Nicole L., Allan C. deCamp, Bette T. Korber, Hua-Xin Liao, Carmela Irene, Abraham Pinter, James Peacock, et al. “HIV-1 Envelope Glycoproteins from Diverse Clades Differentiate Antibody Responses and Durability among Vaccinees.” J Virol 92, no. 8 (April 15, 2018). https://doi.org/10.1128/JVI.01843-17.Full Text Open Access Copy Link to Item
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Wills, Saintedym, Kwan-Ki Hwang, Pinghuang Liu, S Moses Dennison, Matthew Zirui Tay, Xiaoying Shen, Justin Pollara, et al. “HIV-1-Specific IgA Monoclonal Antibodies from an HIV-1 Vaccinee Mediate Galactosylceramide Blocking and Phagocytosis.” J Virol 92, no. 7 (April 1, 2018). https://doi.org/10.1128/JVI.01552-17.Full Text Link to Item
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Fong, Youyi, Xiaoying Shen, Vicki C. Ashley, Aaron Deal, Kelly E. Seaton, Chenchen Yu, Shannon P. Grant, et al. “Modification of the Association Between T-Cell Immune Responses and Human Immunodeficiency Virus Type 1 Infection Risk by Vaccine-Induced Antibody Responses in the HVTN 505 Trial.” J Infect Dis 217, no. 8 (March 28, 2018): 1280–88. https://doi.org/10.1093/infdis/jiy008.Full Text Link to Item
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Nguyen, Quang N., David R. Martinez, Jonathon E. Himes, R. Whitney Edwards, Qifeng Han, Amit Kumar, Riley Mangan, et al. “Predominant envelope variable loop 2-specific and gp120-specific antibody-dependent cellular cytotoxicity antibody responses in acutely SIV-infected African green monkeys.” Retrovirology 15, no. 1 (March 9, 2018): 24. https://doi.org/10.1186/s12977-018-0406-5.Full Text Link to Item
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Jones, Andrew T., Venkateswarlu Chamcha, Sannula Kesavardhana, Xiaoying Shen, David Beaumont, Raksha Das, Linda S. Wyatt, et al. “A Trimeric HIV-1 Envelope gp120 Immunogen Induces Potent and Broad Anti-V1V2 Loop Antibodies against HIV-1 in Rabbits and Rhesus Macaques.” J Virol 92, no. 5 (March 1, 2018). https://doi.org/10.1128/JVI.01796-17.Full Text Link to Item
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Wen, Yingxia, Hung V. Trinh, Christine E. Linton, Chiara Tani, Nathalie Norais, DeeAnn Martinez-Guzman, Priyanka Ramesh, et al. “Generation and characterization of a bivalent protein boost for future clinical trials: HIV-1 subtypes CR01_AE and B gp120 antigens with a potent adjuvant.” Plos One 13, no. 4 (2018): e0194266. https://doi.org/10.1371/journal.pone.0194266.Full Text Link to Item
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Blasi, Maria, Donatella Negri, Celia LaBranche, S Munir Alam, Erich J. Baker, Elizabeth C. Brunner, Morgan A. Gladden, et al. “IDLV-HIV-1 Env vaccination in non-human primates induces affinity maturation of antigen-specific memory B cells.” Commun Biol 1 (2018): 134. https://doi.org/10.1038/s42003-018-0131-6.Full Text Open Access Copy Link to Item
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Saunders, Kevin O., Laurent K. Verkoczy, Chuancang Jiang, Jinsong Zhang, Robert Parks, Haiyan Chen, Max Housman, et al. “Vaccine Induction of Heterologous Tier 2 HIV-1 Neutralizing Antibodies in Animal Models.” Cell Rep 21, no. 13 (December 26, 2017): 3681–90. https://doi.org/10.1016/j.celrep.2017.12.028.Full Text Link to Item
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Seaton, Kelly E., Nathan A. Vandergrift, Aaron W. Deal, Wes Rountree, John Bainbridge, Eduard Grebe, David A. Anderson, et al. “Computational analysis of antibody dynamics identifies recent HIV-1 infection.” Jci Insight 2, no. 24 (December 21, 2017). https://doi.org/10.1172/jci.insight.94355.Full Text Open Access Copy Link to Item
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Shen, Xiaoying, Rahul Basu, Sheetal Sawant, David Beaumont, Sue Fen Kwa, Celia LaBranche, Kelly E. Seaton, et al. “HIV-1 gp120 and Modified Vaccinia Virus Ankara (MVA) gp140 Boost Immunogens Increase Immunogenicity of a DNA/MVA HIV-1 Vaccine.” J Virol 91, no. 24 (December 15, 2017). https://doi.org/10.1128/JVI.01077-17.Full Text Link to Item
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Phillips, Bonnie, Genevieve G. Fouda, Josh Eudailey, Justin Pollara, Alan D. Curtis, Erika Kunz, Maria Dennis, et al. “Impact of Poxvirus Vector Priming, Protein Coadministration, and Vaccine Intervals on HIV gp120 Vaccine-Elicited Antibody Magnitude and Function in Infant Macaques.” Clin Vaccine Immunol 24, no. 10 (October 2017). https://doi.org/10.1128/CVI.00231-17.Full Text Link to Item
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Shen, Xiaoying, Willy M. Bogers, Nicole L. Yates, Guido Ferrari, Antu K. Dey, William T. Williams, Frederick H. Jaeger, et al. “Cross-Linking of a CD4-Mimetic Miniprotein with HIV-1 Env gp140 Alters Kinetics and Specificities of Antibody Responses against HIV-1 Env in Macaques.” J Virol 91, no. 19 (October 1, 2017). https://doi.org/10.1128/JVI.00401-17.Full Text Link to Item
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Bradley, Todd, Justin Pollara, Sampa Santra, Nathan Vandergrift, Srivamshi Pittala, Chris Bailey-Kellogg, Xiaoying Shen, et al. “Pentavalent HIV-1 vaccine protects against simian-human immunodeficiency virus challenge.” Nat Commun 8 (June 8, 2017): 15711. https://doi.org/10.1038/ncomms15711.Full Text Link to Item
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Zurawski, Gerard, Xiaoying Shen, Sandra Zurawski, Georgia D. Tomaras, David C. Montefiori, Mario Roederer, Guido Ferrari, et al. “Superiority in Rhesus Macaques of Targeting HIV-1 Env gp140 to CD40 versus LOX-1 in Combination with Replication-Competent NYVAC-KC for Induction of Env-Specific Antibody and T Cell Responses.” J Virol 91, no. 9 (May 1, 2017). https://doi.org/10.1128/JVI.01596-16.Full Text Link to Item
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Ferrari, Guido, Justin Pollara, Georgia D. Tomaras, and Barton F. Haynes. “Humoral and Innate Antiviral Immunity as Tools to Clear Persistent HIV Infection.” J Infect Dis 215, no. suppl_3 (March 15, 2017): S152–59. https://doi.org/10.1093/infdis/jiw555.Full Text Link to Item
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Wiehe, Kevin, Nathan I. Nicely, Bradley Lockwood, Masayuki Kuraoka, Kara Anasti, Sabrina Arora, Cindy M. Bowman, et al. “Immunodominance of Antibody Recognition of the HIV Envelope V2 Region in Ig-Humanized Mice.” J Immunol 198, no. 3 (February 1, 2017): 1047–55. https://doi.org/10.4049/jimmunol.1601640.Full Text Link to Item
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Chang, WL William, Denise F. Gonzalez, Hung T. Kieu, Luis D. Castillo, Ilhem Messaoudi, Xiaoying Shen, Georgia D. Tomaras, Barbara L. Shacklett, Peter A. Barry, and Ellen E. Sparger. “Changes in Circulating B Cell Subsets Associated with Aging and Acute SIV Infection in Rhesus Macaques.” Plos One 12, no. 1 (2017): e0170154. https://doi.org/10.1371/journal.pone.0170154.Full Text Link to Item
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Tomaras, Georgia D., and Stanley A. Plotkin. “Complex immune correlates of protection in HIV-1 vaccine efficacy trials.” Immunol Rev 275, no. 1 (January 2017): 245–61. https://doi.org/10.1111/imr.12514.Full Text Link to Item
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deCamp, Allan C., Morgane Rolland, Paul T. Edlefsen, Eric Sanders-Buell, Breana Hall, Craig A. Magaret, Andrew J. Fiore-Gartland, et al. “Sieve analysis of breakthrough HIV-1 sequences in HVTN 505 identifies vaccine pressure targeting the CD4 binding site of Env-gp120.” Plos One 12, no. 11 (2017): e0185959. https://doi.org/10.1371/journal.pone.0185959.Full Text Link to Item
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Negri, Donatella, Maria Blasi, Celia LaBranche, Robert Parks, Harikrishnan Balachandran, Michelle Lifton, Xiaoying Shen, et al. “Immunization with an SIV-based IDLV Expressing HIV-1 Env 1086 Clade C Elicits Durable Humoral and Cellular Responses in Rhesus Macaques.” Mol Ther 24, no. 11 (November 2016): 2021–32. https://doi.org/10.1038/mt.2016.123.Full Text Open Access Copy Link to Item
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Gordon, Shari N., Namal P. M. Liyanage, Melvin N. Doster, Monica Vaccari, Diego A. Vargas-Inchaustegui, Poonam Pegu, Luca Schifanella, et al. “Boosting of ALVAC-SIV Vaccine-Primed Macaques with the CD4-SIVgp120 Fusion Protein Elicits Antibodies to V2 Associated with a Decreased Risk of SIVmac251 Acquisition.” J Immunol 197, no. 7 (October 1, 2016): 2726–37. https://doi.org/10.4049/jimmunol.1600674.Full Text Link to Item
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Iyer, Smita S., Sailaja Gangadhara, Blandine Victor, Xiaoying Shen, Xuemin Chen, Rafiq Nabi, Sudhir P. Kasturi, et al. “Virus-Like Particles Displaying Trimeric Simian Immunodeficiency Virus (SIV) Envelope gp160 Enhance the Breadth of DNA/Modified Vaccinia Virus Ankara SIV Vaccine-Induced Antibody Responses in Rhesus Macaques.” J Virol 90, no. 19 (October 1, 2016): 8842–54. https://doi.org/10.1128/JVI.01163-16.Full Text Link to Item
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Townsley, Samantha, Zeinab Mohamed, Wenjin Guo, Jennifer McKenna, Brad Cleveland, Celia LaBranche, David Beaumont, et al. “Induction of Heterologous Tier 2 HIV-1-Neutralizing and Cross-Reactive V1/V2-Specific Antibodies in Rabbits by Prime-Boost Immunization.” J Virol 90, no. 19 (October 1, 2016): 8644–60. https://doi.org/10.1128/JVI.00853-16.Full Text Link to Item
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Abdulhaqq, S. A., C. Zorrilla, G. Kang, X. Yin, V. Tamayo, K. E. Seaton, J. Joseph, et al. “HIV-1-negative female sex workers sustain high cervical IFNÉ›, low immune activation, and low expression of HIV-1-required host genes.” Mucosal Immunol 9, no. 4 (July 2016): 1027–38. https://doi.org/10.1038/mi.2015.116.Full Text Link to Item
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Vaccari, Monica, Shari N. Gordon, Slim Fourati, Luca Schifanella, Namal P. M. Liyanage, Mark Cameron, Brandon F. Keele, et al. “Adjuvant-dependent innate and adaptive immune signatures of risk of SIVmac251 acquisition.” Nat Med 22, no. 7 (July 2016): 762–70. https://doi.org/10.1038/nm.4105.Full Text Link to Item
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Li, Hui, Shuyi Wang, Rui Kong, Wenge Ding, Fang-Hua Lee, Zahra Parker, Eunlim Kim, et al. “Envelope residue 375 substitutions in simian-human immunodeficiency viruses enhance CD4 binding and replication in rhesus macaques.” Proc Natl Acad Sci U S A 113, no. 24 (June 14, 2016): E3413–22. https://doi.org/10.1073/pnas.1606636113.Full Text Link to Item
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Le Grand, Roger, Nathalie Dereuddre-Bosquet, Stefania Dispinseri, Leslie Gosse, Delphine Desjardins, Xiaoying Shen, Monica Tolazzi, et al. “Superior Efficacy of a Human Immunodeficiency Virus Vaccine Combined with Antiretroviral Prevention in Simian-Human Immunodeficiency Virus-Challenged Nonhuman Primates.” J Virol 90, no. 11 (June 1, 2016): 5315–28. https://doi.org/10.1128/JVI.00230-16.Full Text Link to Item
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Nelson, Cody S., Justin Pollara, Erika L. Kunz, Thomas L. Jeffries, Ryan Duffy, Charles Beck, Lisa Stamper, et al. “Combined HIV-1 Envelope Systemic and Mucosal Immunization of Lactating Rhesus Monkeys Induces a Robust Immunoglobulin A Isotype B Cell Response in Breast Milk.” J Virol 90, no. 10 (May 15, 2016): 4951–65. https://doi.org/10.1128/JVI.00335-16.Full Text Link to Item
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Walsh, Stephen R., Zoe Moodie, Andrew J. Fiore-Gartland, Cecilia Morgan, Marissa B. Wilck, Scott M. Hammer, Susan P. Buchbinder, et al. “Vaccination With Heterologous HIV-1 Envelope Sequences and Heterologous Adenovirus Vectors Increases T-Cell Responses to Conserved Regions: HVTN 083.” J Infect Dis 213, no. 4 (February 15, 2016): 541–50. https://doi.org/10.1093/infdis/jiv496.Full Text Link to Item
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Zurawski, Gerard, Sandra Zurawski, Anne-Laure Flamar, Laura Richert, Ralf Wagner, Georgia D. Tomaras, David C. Montefiori, et al. “Targeting HIV-1 Env gp140 to LOX-1 Elicits Immune Responses in Rhesus Macaques.” Plos One 11, no. 4 (2016): e0153484. https://doi.org/10.1371/journal.pone.0153484.Full Text Link to Item
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Churchyard, Gavin, Koleka Mlisana, Shelly Karuna, Anna-Lise Williamson, Carolyn Williamson, Lynn Morris, Georgia D. Tomaras, et al. “Sequential Immunization with gp140 Boosts Immune Responses Primed by Modified Vaccinia Ankara or DNA in HIV-Uninfected South African Participants.” Plos One 11, no. 9 (2016): e0161753. https://doi.org/10.1371/journal.pone.0161753.Full Text Link to Item
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Cosgrove, Catherine A., Charles J. Lacey, Alethea V. Cope, Angela Bartolf, Georgina Morris, Celine Yan, Susan Baden, et al. “Comparative Immunogenicity of HIV-1 gp140 Vaccine Delivered by Parenteral, and Mucosal Routes in Female Volunteers; MUCOVAC2, A Randomized Two Centre Study.” Plos One 11, no. 5 (2016): e0152038. https://doi.org/10.1371/journal.pone.0152038.Full Text Link to Item
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Safrit, Jeffrey T., Georgia D. Tomaras, Tomáš Hanke, Allan C. deCamp, and Yegor Voronin. “The Landscape of Targeted Immune Responses in the HIV-1 Vaccine Field.” Aids Res Hum Retroviruses 32, no. 10–11 (2016): 944–46. https://doi.org/10.1089/AID.2016.0120.Full Text Link to Item
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Sajadi, Mohammad M., Maham Farshidpour, Eric P. Brown, Xin Ouyang, Michael S. Seaman, Marzena Pazgier, Margaret E. Ackerman, et al. “λ Light Chain Bias Associated With Enhanced Binding and Function of Anti-HIV Env Glycoprotein Antibodies.” J Infect Dis 213, no. 1 (January 1, 2016): 156–64. https://doi.org/10.1093/infdis/jiv448.Full Text Link to Item
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Cubas, Rafael, Julien van Grevenynghe, Saintedym Wills, Lela Kardava, Brian H. Santich, Clarisa M. Buckner, Roshell Muir, et al. “Reversible Reprogramming of Circulating Memory T Follicular Helper Cell Function during Chronic HIV Infection.” J Immunol 195, no. 12 (December 15, 2015): 5625–36. https://doi.org/10.4049/jimmunol.1501524.Full Text Link to Item
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García-Arriaza, Juan, Beatriz Perdiguero, Jonathan Heeney, Michael Seaman, David C. Montefiori, Celia Labranche, Nicole L. Yates, et al. “Head-to-Head Comparison of Poxvirus NYVAC and ALVAC Vectors Expressing Identical HIV-1 Clade C Immunogens in Prime-Boost Combination with Env Protein in Nonhuman Primates.” J Virol 89, no. 16 (August 2015): 8525–39. https://doi.org/10.1128/JVI.01265-15.Full Text Link to Item
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Shen, Xiaoying, Ryan Duffy, Robert Howington, Alethea Cope, Shanmugalakshmi Sadagopal, Haesun Park, Ranajit Pal, et al. “Vaccine-Induced Linear Epitope-Specific Antibodies to Simian Immunodeficiency Virus SIVmac239 Envelope Are Distinct from Those Induced to the Human Immunodeficiency Virus Type 1 Envelope in Nonhuman Primates.” J Virol 89, no. 16 (August 2015): 8643–50. https://doi.org/10.1128/JVI.03635-14.Full Text Link to Item
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Santra, Sampa, Georgia D. Tomaras, Ranjit Warrier, Nathan I. Nicely, Hua-Xin Liao, Justin Pollara, Pinghuang Liu, et al. “Human Non-neutralizing HIV-1 Envelope Monoclonal Antibodies Limit the Number of Founder Viruses during SHIV Mucosal Infection in Rhesus Macaques.” Plos Pathog 11, no. 8 (August 2015): e1005042. https://doi.org/10.1371/journal.ppat.1005042.Full Text Open Access Copy Link to Item
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Prentice, Heather A., Georgia D. Tomaras, Daniel E. Geraghty, Richard Apps, Youyi Fong, Philip K. Ehrenberg, Morgane Rolland, et al. “HLA class II genes modulate vaccine-induced antibody responses to affect HIV-1 acquisition.” Sci Transl Med 7, no. 296 (July 15, 2015): 296ra112. https://doi.org/10.1126/scitranslmed.aab4005.Full Text Link to Item
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Kwa, Suefen, Shanmugalakshmi Sadagopal, Xiaoying Shen, Jung Joo Hong, Sailaja Gangadhara, Rahul Basu, Blandine Victor, et al. “CD40L-adjuvanted DNA/modified vaccinia virus Ankara simian immunodeficiency virus (SIV) vaccine enhances protection against neutralization-resistant mucosal SIV infection.” J Virol 89, no. 8 (April 2015): 4690–95. https://doi.org/10.1128/JVI.03527-14.Full Text Link to Item
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Bogers, Willy M., Herman Oostermeijer, Petra Mooij, Gerrit Koopman, Ernst J. Verschoor, David Davis, Jeffrey B. Ulmer, et al. “Potent immune responses in rhesus macaques induced by nonviral delivery of a self-amplifying RNA vaccine expressing HIV type 1 envelope with a cationic nanoemulsion.” J Infect Dis 211, no. 6 (March 15, 2015): 947–55. https://doi.org/10.1093/infdis/jiu522.Full Text Link to Item
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Fouda, Genevieve G., Coleen K. Cunningham, Elizabeth J. McFarland, William Borkowsky, Petronella Muresan, Justin Pollara, Lin Ye Song, et al. “Infant HIV type 1 gp120 vaccination elicits robust and durable anti-V1V2 immunoglobulin G responses and only rare envelope-specific immunoglobulin A responses.” J Infect Dis 211, no. 4 (February 15, 2015): 508–17. https://doi.org/10.1093/infdis/jiu444.Full Text Link to Item
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Bart, Pierre-Alexandre, Yunda Huang, Shelly T. Karuna, Samuel Chappuis, Julien Gaillard, Nidhi Kochar, Xiaoying Shen, et al. “HIV-specific humoral responses benefit from stronger prime in phase Ib clinical trial.” J Clin Invest 124, no. 11 (November 2014): 4843–56. https://doi.org/10.1172/JCI75894.Full Text Link to Item
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Stieh, Daniel J., Deborah F. King, Katja Klein, Pinghuang Liu, Xiaoying Shen, Kwan Ki Hwang, Guido Ferrari, et al. “Aggregate complexes of HIV-1 induced by multimeric antibodies.” Retrovirology 11 (October 2, 2014): 78. https://doi.org/10.1186/s12977-014-0078-8.Full Text Open Access Copy Link to Item
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Liu, Pinghuang, Latonya D. Williams, Xiaoying Shen, Mattia Bonsignori, Nathan A. Vandergrift, R Glenn Overman, M Anthony Moody, et al. “Capacity for infectious HIV-1 virion capture differs by envelope antibody specificity.” J Virol 88, no. 9 (May 2014): 5165–70. https://doi.org/10.1128/JVI.03765-13.Full Text Link to Item
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Jalah, Rashmi, Viraj Kulkarni, Vainav Patel, Margherita Rosati, Candido Alicea, Jenifer Bear, Lei Yu, et al. “DNA and protein co-immunization improves the magnitude and longevity of humoral immune responses in macaques.” Plos One 9, no. 3 (2014): e91550. https://doi.org/10.1371/journal.pone.0091550.Full Text Link to Item
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Roederer, M., B. F. Keele, S. D. Schmidt, R. D. Mason, H. C. Welles, W. Fischer, C. Labranche, et al. “Immunological and virological mechanisms of vaccine-mediated protection against SIV and HIV.” Nature 505, no. 7484 (January 1, 2014): 502–8. https://doi.org/10.1038/nature12893.Full Text Open Access Copy
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Seaton, Kelly E., Lamar Ballweber, Audrey Lan, Michele Donathan, Sean Hughes, Lucia Vojtech, M Anthony Moody, et al. “HIV-1 specific IgA detected in vaginal secretions of HIV uninfected women participating in a microbicide trial in Southern Africa are primarily directed toward gp120 and gp140 specificities.” Plos One 9, no. 7 (2014): e101863. https://doi.org/10.1371/journal.pone.0101863.Full Text Link to Item
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Kulkarni, Viraj, Margherita Rosati, Antonio Valentin, Rashmi Jalah, Candido Alicea, Lei Yu, Yongjun Guan, et al. “Vaccination with Vaxfectin(®) adjuvanted SIV DNA induces long-lasting humoral immune responses able to reduce SIVmac251 Viremia.” Hum Vaccin Immunother 9, no. 10 (October 2013): 2069–80. https://doi.org/10.4161/hv.25442.Full Text Link to Item
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Imholte, Greg C., Renan Sauteraud, Bette Korber, Robert T. Bailer, Ellen T. Turk, Xiaoying Shen, Georgia D. Tomaras, et al. “A computational framework for the analysis of peptide microarray antibody binding data with application to HIV vaccine profiling.” J Immunol Methods 395, no. 1–2 (September 30, 2013): 1–13. https://doi.org/10.1016/j.jim.2013.06.001.Full Text Link to Item
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Schiffner, T., L. Kong, C. J. A. Duncan, J. W. Back, J. J. Benschop, X. Shen, P. S. Huang, et al. “Immune focusing and enhanced neutralization induced by HIV-1 gp140 chemical cross-linking.” J Virol 87, no. 18 (September 2013): 10163–72. https://doi.org/10.1128/JVI.01161-13.Full Text Link to Item
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Liu, Pinghuang, Nicole L. Yates, Xiaoying Shen, Mattia Bonsignori, M Anthony Moody, Hua-Xin Liao, Youyi Fong, et al. “Infectious virion capture by HIV-1 gp120-specific IgG from RV144 vaccinees.” J Virol 87, no. 14 (July 2013): 7828–36. https://doi.org/10.1128/JVI.02737-12.Full Text Open Access Copy Link to Item
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Tomaras, Georgia D., Guido Ferrari, Xiaoying Shen, S Munir Alam, Hua-Xin Liao, Justin Pollara, Mattia Bonsignori, et al. “Vaccine-induced plasma IgA specific for the C1 region of the HIV-1 envelope blocks binding and effector function of IgG.” Proc Natl Acad Sci U S A 110, no. 22 (May 28, 2013): 9019–24. https://doi.org/10.1073/pnas.1301456110.Full Text Link to Item
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Patel, Vainav, Rashmi Jalah, Viraj Kulkarni, Antonio Valentin, Margherita Rosati, Candido Alicea, Agneta von Gegerfelt, et al. “DNA and virus particle vaccination protects against acquisition and confers control of viremia upon heterologous simian immunodeficiency virus challenge.” Proc Natl Acad Sci U S A 110, no. 8 (February 19, 2013): 2975–80. https://doi.org/10.1073/pnas.1215393110.Full Text Link to Item
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Gottardo, Raphael, Robert T. Bailer, Bette T. Korber, S. Gnanakaran, Joshua Phillips, Xiaoying Shen, Georgia D. Tomaras, et al. “Plasma IgG to linear epitopes in the V2 and V3 regions of HIV-1 gp120 correlate with a reduced risk of infection in the RV144 vaccine efficacy trial.” Plos One 8, no. 9 (2013): e75665. https://doi.org/10.1371/journal.pone.0075665.Full Text Link to Item
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Zolla-Pazner, Susan, Allan C. deCamp, Timothy Cardozo, Nicos Karasavvas, Raphael Gottardo, Constance Williams, Daryl E. Morris, et al. “Analysis of V2 antibody responses induced in vaccinees in the ALVAC/AIDSVAX HIV-1 vaccine efficacy trial.” Plos One 8, no. 1 (2013): e53629. https://doi.org/10.1371/journal.pone.0053629.Full Text Link to Item
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Karasavvas, Nicos, Erik Billings, Mangala Rao, Constance Williams, Susan Zolla-Pazner, Robert T. Bailer, Richard A. Koup, et al. “The Thai Phase III HIV Type 1 Vaccine trial (RV144) regimen induces antibodies that target conserved regions within the V2 loop of gp120.” Aids Res Hum Retroviruses 28, no. 11 (November 2012): 1444–57. https://doi.org/10.1089/aid.2012.0103.Full Text Link to Item
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Haynes, Barton F., Peter B. Gilbert, M Juliana McElrath, Susan Zolla-Pazner, Georgia D. Tomaras, S Munir Alam, David T. Evans, et al. “Immune-correlates analysis of an HIV-1 vaccine efficacy trial.” N Engl J Med 366, no. 14 (April 5, 2012): 1275–86. https://doi.org/10.1056/NEJMoa1113425.Full Text Link to Item
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Tomaras, Georgia D., James M. Binley, Elin S. Gray, Emma T. Crooks, Keiko Osawa, Penny L. Moore, Nancy Tumba, et al. “Polyclonal B cell responses to conserved neutralization epitopes in a subset of HIV-1-infected individuals.” J Virol 85, no. 21 (November 2011): 11502–19. https://doi.org/10.1128/JVI.05363-11.Full Text Link to Item
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Zhu, Zhongyu, Haiyan Rebekah Qin, Weizao Chen, Qi Zhao, Xiaoying Shen, Robert Schutte, Yanping Wang, et al. “Cross-reactive HIV-1-neutralizing human monoclonal antibodies identified from a patient with 2F5-like antibodies.” J Virol 85, no. 21 (November 2011): 11401–8. https://doi.org/10.1128/JVI.05312-11.Full Text Link to Item
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Fouda, Genevieve G., Nicole L. Yates, Justin Pollara, Xiaoying Shen, Glenn R. Overman, Tatenda Mahlokozera, Andrew B. Wilks, et al. “HIV-specific functional antibody responses in breast milk mirror those in plasma and are primarily mediated by IgG antibodies.” J Virol 85, no. 18 (September 2011): 9555–67. https://doi.org/10.1128/JVI.05174-11.Full Text Open Access Copy Link to Item
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Spearman, Paul, Michelle A. Lally, Marnie Elizaga, David Montefiori, Georgia D. Tomaras, M Juliana McElrath, John Hural, et al. “A trimeric, V2-deleted HIV-1 envelope glycoprotein vaccine elicits potent neutralizing antibodies but limited breadth of neutralization in human volunteers.” J Infect Dis 203, no. 8 (April 15, 2011): 1165–73. https://doi.org/10.1093/infdis/jiq175.Full Text Link to Item
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Shen, Xiaoying, and Georgia D. Tomaras. “Alterations of the B-cell response by HIV-1 replication.” Curr Hiv/Aids Rep 8, no. 1 (March 2011): 23–30. https://doi.org/10.1007/s11904-010-0064-2.Full Text Link to Item
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Dennison, S Moses, Laura L. Sutherland, Frederick H. Jaeger, Kara M. Anasti, Robert Parks, Shelley Stewart, Cindy Bowman, et al. “Induction of antibodies in rhesus macaques that recognize a fusion-intermediate conformation of HIV-1 gp41.” Plos One 6, no. 11 (2011): e27824. https://doi.org/10.1371/journal.pone.0027824.Full Text Link to Item
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Liu, Jinyan, Brandon F. Keele, Hui Li, Sheila Keating, Philip J. Norris, Angela Carville, Keith G. Mansfield, et al. “Low-dose mucosal simian immunodeficiency virus infection restricts early replication kinetics and transmitted virus variants in rhesus monkeys.” J Virol 84, no. 19 (October 2010): 10406–12. https://doi.org/10.1128/JVI.01155-10.Full Text Link to Item
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Haynes, Barton F., Hua-Xin Liao, and Georgia D. Tomaras. “Is developing an HIV-1 vaccine possible?” Curr Opin Hiv Aids 5, no. 5 (September 2010): 362–67. https://doi.org/10.1097/COH.0b013e32833d2e90.Full Text Link to Item
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Tomaras, Georgia D., and Barton F. Haynes. “Strategies for eliciting HIV-1 inhibitory antibodies.” Curr Opin Hiv Aids 5, no. 5 (September 2010): 421–27. https://doi.org/10.1097/COH.0b013e32833d2d45.Full Text Link to Item
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Shen, Xiaoying, S Moses Dennison, Pinghuang Liu, Feng Gao, Frederick Jaeger, David C. Montefiori, Laurent Verkoczy, Barton F. Haynes, S Munir Alam, and Georgia D. Tomaras. “Prolonged exposure of the HIV-1 gp41 membrane proximal region with L669S substitution.” Proc Natl Acad Sci U S A 107, no. 13 (March 30, 2010): 5972–77. https://doi.org/10.1073/pnas.0912381107.Full Text Link to Item
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Bonsignori, Mattia, M Anthony Moody, Robert J. Parks, T Matt Holl, Garnett Kelsoe, Charles B. Hicks, Nathan Vandergrift, Georgia D. Tomaras, and Barton F. Haynes. “HIV-1 envelope induces memory B cell responses that correlate with plasma antibody levels after envelope gp120 protein vaccination or HIV-1 infection.” J Immunol 183, no. 4 (August 15, 2009): 2708–17. https://doi.org/10.4049/jimmunol.0901068.Full Text Link to Item
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Levesque, Marc C., M Anthony Moody, Kwan-Ki Hwang, Dawn J. Marshall, John F. Whitesides, Joshua D. Amos, Thaddeus C. Gurley, et al. “Polyclonal B cell differentiation and loss of gastrointestinal tract germinal centers in the earliest stages of HIV-1 infection.” Plos Med 6, no. 7 (July 7, 2009): e1000107. https://doi.org/10.1371/journal.pmed.1000107.Full Text Open Access Copy Link to Item
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Maksaereekul, Saipiroon, Robert A. Dubie, Xiaoying Shen, Hung Kieu, Gregg A. Dean, and Ellen E. Sparger. “Vaccination with vif-deleted feline immunodeficiency virus provirus, GM-CSF, and TNF-alpha plasmids preserves global CD4 T lymphocyte function after challenge with FIV.” Vaccine 27, no. 28 (June 8, 2009): 3754–65. https://doi.org/10.1016/j.vaccine.2009.03.081.Full Text Link to Item
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Miller, Heather B., Kevin O. Saunders, Georgia D. Tomaras, and Mariano A. Garcia-Blanco. “Tat-SF1 is not required for Tat transactivation but does regulate the relative levels of unspliced and spliced HIV-1 RNAs.” Plos One 4, no. 5 (May 27, 2009): e5710. https://doi.org/10.1371/journal.pone.0005710.Full Text Link to Item
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Lambotte, Olivier, Guido Ferrari, Christiane Moog, Nicole L. Yates, Hua-Xin Liao, Robert J. Parks, Charles B. Hicks, et al. “Heterogeneous neutralizing antibody and antibody-dependent cell cytotoxicity responses in HIV-1 elite controllers.” Aids 23, no. 8 (May 15, 2009): 897–906. https://doi.org/10.1097/QAD.0b013e328329f97d.Full Text Link to Item
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Shen, Xiaoying, Robert J. Parks, David C. Montefiori, Jennifer L. Kirchherr, Brandon F. Keele, Julie M. Decker, William A. Blattner, et al. “In vivo gp41 antibodies targeting the 2F5 monoclonal antibody epitope mediate human immunodeficiency virus type 1 neutralization breadth.” J Virol 83, no. 8 (April 2009): 3617–25. https://doi.org/10.1128/JVI.02631-08.Full Text Link to Item
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Shen, Xiaoying, Christian M. Leutenegger, Kelly Stefano Cole, Niels C. Pedersen, and Ellen E. Sparger. “A feline immunodeficiency virus vif-deletion mutant remains attenuated upon infection of newborn kittens.” J Gen Virol 88, no. Pt 10 (October 2007): 2793–99. https://doi.org/10.1099/vir.0.83268-0.Full Text Link to Item
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Tomaras, Georgia D., Xiaoying Shen, and Michael L. Greenberg. “Antibody responses and virus escape: implications for HIV-1 vaccine and therapeutic design.” Future Virology 1, no. 1 (January 2006): 79–88. https://doi.org/10.2217/17460794.1.1.79.Full Text
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Conference Papers
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Felber, B., Z. Lu, X. Hu, A. Valentin, M. Rosati, J. A. Weiner, X. Shen, et al. “Comparison of co-immunization of DNA and protein in the same anatomical sites and in contralateral sites to identify mechanisms of protective immune response.” In Journal of the International Aids Society, Vol. 24, 2021.Link to Item
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Jones, Rebecca, Eric Scott, LaShanda Cheston, Morgan Gladden, Shalini Jha, Charles Beck, Justin Pollara, et al. “Vaccine-elicited memory B cells expressing ADCC-mediating antibodies lacking recognition of the V2 region did not correlate with protection of NHPs.” In Journal of Medical Primatology, 49:247–48, 2020.Link to Item
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Shen, Xiaoying, Zoe Moodie, Arthur McMillan, Derrick Goodman, Nicole Yates, Rachel Spreng, Nicole Grunenberg, et al. “V1V2 IgG and Antibody Fc Effector Functions in a Subtype C ALVAC-HIV and Bivalent Subtype C gp120/MF59 HIV-1 Vaccine Trial in South Africa.” In Aids Research and Human Retroviruses, 34:17–17. MARY ANN LIEBERT, INC, 2018.Link to Item
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Sparger, Ellen, William Chang, Jesse Deere, Hung Kieu, Diego Castillo, Shelley Blozis, Jeffrey Lifson, et al. “Impact of a TLR-5 Ligand as Adjuvant on Immunogenicity and Efficacy of a RhCMV-SIV Vaccine.” In Journal of Medical Primatology, 47:313–14. WILEY, 2018.Link to Item
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Vaccari, Monica, Slim Fourati, Shari Gordon, Massimiliano Bissa, Luca Schifanella, Monica Silva de Castro, Trinh Hung, et al. “Vaccine-induced Activation of Inflammasome in Classical Monocytes and Th2 Cell Responses Correlates With Decreased Risk of SIVmac251 Acquisition.” In Aids Research and Human Retroviruses, 34:73–73. MARY ANN LIEBERT, INC, 2018.Link to Item
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Williams, LaTonya, Matthew Zirui Tay, Xiaoying Shen, Sheetal Sawant, Lindsay Dahora, Nicole Yates, David Easterhoff, et al. “Delayed and Repetitive Boosting of RV144 Vaccinees Improves Antiviral Immunity Associated With Correlates of HIV-1 Infection Risk.” In Aids Research and Human Retroviruses, 34:88–88. MARY ANN LIEBERT, INC, 2018.Link to Item
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Shen, Xiaoying, Rahul Basu, Suefen Kwa, Celia Labranche, David Beaumont, Guido Ferrari, Linda Wyatt, et al. “MVA-expressed gp140 Boosts More Durable V1/V2 and gp120 Antibody Responses than gp120 Protein in Alum.” In Aids Research and Human Retroviruses, 32:59–59. MARY ANN LIEBERT, INC, 2016.Link to Item
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Valentin, Antonio, Jinyao Li, Rashmi Jalah, Vainav Patel, Margherita Rosati, Viraj Kulkarni, Candido Alicea, et al. “DNA AND PROTEIN CO-IMMUNIZATION IMPROVES THE MAGNITUDE, LONGEVITY, AND MUCOSAL DISSEMINATION OF IMMUNE RESPONSES.” In Journal of Medical Primatology, 44:341–341. WILEY-BLACKWELL, 2015.Link to Item
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Fourati, S., M. Vaccari, S. N. Gordon, L. Schifanella, M. Cameron, B. F. Keele, X. Shen, et al. “Modulation of RAS Pathways as a Biomarker of Protection against HIV and as a Means to Improve Vaccine Efficacy.” In Aids Res Hum Retroviruses, 30 Suppl 1:A99, 2014. https://doi.org/10.1089/aid.2014.5182b.abstract.Full Text Link to Item
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Pavlakis, G. N., J. Li, A. Valentin, R. Jalah, V. Patel, M. Rosati, V. Kulkarni, et al. “DNA and Protein Co-immunization Improves the Magnitude, Longevity, and Mucosal Dissemination of Immune Responses.” In Aids Res Hum Retroviruses, 30 Suppl 1:A63–64, 2014. https://doi.org/10.1089/aid.2014.5115.abstract.Full Text Link to Item
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Shen, Xiaoying, William Williams, Nicole Yates, Joe Francica, Keith Reimann, David Montefiori, Julie McElrath, Robert Seder, and Georgia Tomaras. “HIV ENV-SPECIFIC IGG3 RESPONSES ARE DIFFERENTIALLY ELICITED IN NONHUMAN PRIMATE BY ENV VACCINES WITH DIFFERENT ADJUVANTS.” In Journal of Medical Primatology, 43:421–421. WILEY-BLACKWELL, 2014.Link to Item
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Vaccari, M., S. N. Gordon, S. Fourati, L. Schifanella, M. Cameron, B. F. Keele, X. Shen, et al. “Adjuvant Dependent Mucosal V2 Responses and RAS Activation in Vaccine Induced Protection from SIVmac251 Acquisition.” In Aids Res Hum Retroviruses, 30 Suppl 1:A64–65, 2014. https://doi.org/10.1089/aid.2014.5117.abstract.Full Text Link to Item
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Schifanella, Luca, Nicolo Binello, Monica Vaccari, Shari N. Gordon, Francesca Caccuri, Matthew Blackburn, Melvin Doster, et al. “Plasmablast Phenotype and Mucosal Antibodies to V2 in Vaccine-induced Protection Against SIVmac251.” In Aids Research and Human Retroviruses, 30:A20–A20. Mary Ann Liebert Inc, 2014. https://doi.org/10.1089/aid.2014.5024.abstract.Full Text
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Gordon, S. N., M. Vaccari, M. N. Doster, N. P. Liyanage, P. Pegu, L. Schifanella, F. Caccuri, et al. “Priming with Adenovirus26 Vaccines Affects ALVAC-SIV/gp120 Vaccine Efficacy Tested in a SIVmac251 Challenge Model Performed One-Month Post-Vaccination.” In Aids Research and Human Retroviruses, 29:A39–A39. MARY ANN LIEBERT, INC, 2013.Link to Item
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Schifanella, L., S. Gordon, M. Vaccari, N. Binello, F. Caccuri, M. Blackburn, C. Fenizia, et al. “MF59 and ALUM, in Combination with an ALVAC-SIV/gp120 Vaccine, Induce Plasmablasts that Differ in the Expression of Homing Markers.” In Aids Research and Human Retroviruses, 29:A13–A13. MARY ANN LIEBERT, INC, 2013.Link to Item
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Shen, X., R. Howington, H. Park, S. Sadagopal, S. Kwa, A. Cope, S. Ding, et al. “Vaccine Induced Epitope Specific Antibodies to the SIV Envelope Are Distinct from Those Induced to the HIV-1 Envelope.” In Aids Research and Human Retroviruses, 29:A10–11. MARY ANN LIEBERT, INC, 2013.Link to Item
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Vaccari, M., S. N. Gordon, M. Doster, N. Liynage, P. Pegu, L. Schifanella, B. F. Keele, et al. “Protection from SIVmac251 Acquisition by an ALVAC/SIV/gp120 Regimen Is Not Improved by the Increase of Anti-Envelope Antibodies and T Cell Responses.” In Aids Research and Human Retroviruses, 29:A34–A34. MARY ANN LIEBERT, INC, 2013.Link to Item
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Blasi, M., D. Negri, S. Santra, R. Parks, X. Shen, G. Tomaras, S. Permar, et al. “A Single Immunization with Integrase Defective Lentiviral Vector Expressing gp140 Induces Persistent and Functional Immune Response in Rhesus Monkeys.” In Aids Research and Human Retroviruses, 29:A161–A161. MARY ANN LIEBERT, INC, 2013.Link to Item
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Zhu, Z., H. R. Qin, W. Chen, Q. Zhao, X. Shen, R. Schutte, Y. Wang, et al. “2F5-like Cross-Reactive HIV-1-Neutralizing Monoclonal Antibodies with Low Number of Somatic Mutations.” In Aids Research and Human Retroviruses, 27:A9–A9. MARY ANN LIEBERT INC, 2011.Link to Item
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Tomaras, G., J. Binley, E. Gray, X. Shen, P. Moore, J. Decker, N. Yates, et al. “Epitope Specificities of Elite Neutralizing Sera from HIV-1-Infected Individuals.” In Aids Research and Human Retroviruses, 26:A24–A24. MARY ANN LIEBERT INC, 2010.Link to Item
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Yates, N., X. Shen, P. Liu, S. Barnett, P. Spearman, S. Lu, G. Ferrari, et al. “Vaccine-Elicited IgG Subclasses and Functional Antibodies.” In Aids Research and Human Retroviruses, 26:A157–A157. MARY ANN LIEBERT INC, 2010.Link to Item
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Zhu, Z., H. R. Qin, W. Chen, Q. Zhao, G. Fouda, R. Schutte, X. Shen, et al. “New broadly neutralizing human monoclonal antibodies targeting the 2F5 epitope.” In Aids Research and Human Retroviruses, 26:A14–15. MARY ANN LIEBERT INC, 2010.Link to Item
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Munshaw, S., H. Liao, A. Dixon, X. Chen, A. Nagel, K. Derosa, R. Parks, et al. “S021-04 OA. A large-scale analysis of immunoglobulin sequences derived from plasmablasts/plasma cells in acute HIV-1 infection subjects.” In Retrovirology, Vol. 6, 2009. https://doi.org/10.1186/1742-4690-6-S3-O4.Full Text
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Robinson, H. L., R. R. Amara, L. Lai, Y. Xu, S. De Rosa, O. Defawe, A. Sato, et al. “P19-58 LB. Comparison of the immunogenicity in humans and rhesus macaques of vaccines consisting of DNA priming and MVA boosting and MVA priming and boosting.” In Retrovirology, Vol. 6, 2009. https://doi.org/10.1186/1742-4690-6-S3-P422.Full Text
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Shen, X., M. Dennison, F. Gao, D. C. Montefiori, L. Verkoczy, B. Haynes, M. Alam, and G. Tomaras. “OA021-04. HIV-1 gp41 envelope MPER mutation altered epitope conformation in lipid and increased sensitivity to 2F5 and 4E10 neutralizing antibodies.” In Retrovirology, Vol. 6, 2009. https://doi.org/10.1186/1742-4690-6-S3-O16.Full Text
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Freel, S. A., P. K. Chattopadhyay, L. Lamoreaux, D. Zarkowsky, R. G. Overman, C. Ochsenbauer-Jambor, J. C. Kappes, et al. “Abstracts of AIDS Vaccine 2009. Paris, France. October 19-22, 2009.” In Retrovirology, 6 Suppl 3:O1-425, 2009. https://doi.org/10.1186/1742-4690-6-s3-o1.Full Text Link to Item
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Shen, X., D. Montefiori, R. Parks, B. F. Haynes, and G. T. Tomaras. “2F5-Like Antibody Identified from an HIV-Infected Patient Concurrent with the Development of Autoimmune Antibodies.” In Aids Research and Human Retroviruses, 24:53–54. MARY ANN LIEBERT INC, 2008.Link to Item
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