Xiaoying Shen | Scholars@Duke

Xiaoying Shen
Assistant Professor in Medicine

Current Appointments & Affiliations

Assistant Professor in Medicine, Medicine, Duke Human Vaccine Institute, Medicine 2016
Member of the Duke Human Vaccine Institute, Duke Human Vaccine Institute, Institutes and Centers 2007

Contact Information

2 Genome Ct - 4013 MSRB II, Durham, NC 27710
Box 103020 DUMC, Durham, NC 27710
sxshen@duke.edu (919) 681-9739

Background
Education, Training, & Certifications
- Ph.D., University of California at Davis 2004
Duke Appointment History
- Medical Instructor in the Department of Medicine, Medicine, Duke Human Vaccine Institute, Medicine 2011 - 2016
Research
Selected Grants
- Antibody and viral determinants of protection against CMV infection following gB/MF59 vaccination awarded by National Institutes of Health 2017 - 2020
- Nonhuman Primate Core awarded by National Institutes of Health 2018 - 2019
- HVTN Laboratory Center: HVTN 117 awarded by Fred Hutchinson Cancer Research Center 2017 - 2018
- HVTN Laboratory Center: HVTN 118 awarded by Fred Hutchinson Cancer Research Center 2017 - 2018
- HIV Vaccine Trials Network: LC P5 PF awarded by Fred Hutchinson Cancer Research Center 2015 - 2018
- HIV Vaccine Trials Network: LC Phase 1 PF awarded by Fred Hutchinson Cancer Research Center 2015 - 2018
- LC: HIV Vaccine Trials Network awarded by Fred Hutchinson Cancer Research Center 2006 - 2018
- Nonhuman Primate Core-Option 6 awarded by National Institutes of Health 2012 - 2018
- HVTN 505 Protocol awarded by Fred Hutchinson Cancer Research Center 2015 - 2017
- HIV Vaccine Trials Network: LC P5 PF awarded by Fred Hutchinson Cancer Research Center 2014 - 2015
- HVTN 505 Protocol awarded by Fred Hutchinson Cancer Research Center 2014 - 2015
- LC: HIV Vaccine Trials Network: Phase 1 PF awarded by Fred Hutchinson Cancer Research Center 2014 - 2015
- Enhancing protective antibody responses for a GM-CSF adjuvanted HIV vaccine awarded by GeoVax Inc 2014 - 2015
- Testing the ability of antibody-mucin interactions to provide vaccine function awarded by Northwestern University 2013 - 2015
Publications & Artistic Works
Selected Publications
- Conference Papers
  - Felber, BK, Valentin, A, Salazar, ER, Doueiri, R, Rosati, M, Hu, X, Alicea, C, Bear, J, Hirsch, VM, Broderick, KE, Sardesai, NY, Reed, SG, Montefiori, DC, Shen, X, Tomaras, GD, and Pavlakis, GN. "DNA and Protein Co-delivery Vaccines Using TLR-4-based Adjuvants Induce Potent Immune Responses Able to Delay Heterologous SIV Acquisition." October 2016. Link to Item
  - Shen, X, Basu, R, Kwa, S, Labranche, C, Beaumont, D, Ferrari, G, Wyatt, L, Moss, B, Montefiori, D, Tomaras, G, and Robinson, H. "MVA-expressed gp140 Boosts More Durable V1/V2 and gp120 Antibody Responses than gp120 Protein in Alum." October 2016. Link to Item
  - Valentin, A, Li, J, Jalah, R, Patel, V, Rosati, M, Kulkarni, V, Alicea, C, Vargas-Inchaustegui, DA, Guan, Y, Venzon, D, Sardesai, NY, Fouts, TR, Pinter, A, Robert-Guroff, M, Montefiori, DC, Shen, X, Tomaras, GD, Pavlakis, GN, and Felber, BK. "DNA AND PROTEIN CO-IMMUNIZATION IMPROVES THE MAGNITUDE, LONGEVITY, AND MUCOSAL DISSEMINATION OF IMMUNE RESPONSES." October 2015. Link to Item
  - Fourati, S, Vaccari, M, Gordon, SN, Schifanella, L, Cameron, M, Keele, BF, Shen, X, Tomoras, GD, Billings, E, Rao, M, Chung, AW, Dowell, K, Bailey-Kellogg, C, Brown, E, Ackerman, ME, Liyanage, NP, Vargas-Inchaistegui, DA, Whitney, S, Doster, MN, Binello, N, Pegu, P, Montefiori, DC, Foulds, K, Quinn, DS, Donaldson, M, Liang, F, Loré, K, Roederer, M, Koup, RA, McDermott, A, Ma, ZM, Miller, CJ, Phan, TB, Forthal, DN, Blackburn, M, Caccuri, F, Ferrari, G, Thompson, D, Robert-Guroff, M, Ratto-Kim, S, Kim, JH, Michael, NL, Phogat, S, Barnett, SW, Tartaglia, J, Venzon, D, Stablein, DM, Alter, G, Sekaly, RP, and Franchini, G. "Modulation of RAS Pathways as a Biomarker of Protection against HIV and as a Means to Improve Vaccine Efficacy." October 2014. Full Text
  - Pavlakis, GN, Li, J, Valentin, A, Jalah, R, Patel, V, Rosati, M, Kulkarni, V, Alicea, C, Vargas-Inchaustegui, DA, Guan, Y, Venzon, D, Sardesai, N, Fouts, TR, Pinter, A, Robert-Guroff, M, Montefiori, DC, Shen, X, Tomaras, GD, and Felber, BK. "DNA and Protein Co-immunization Improves the Magnitude, Longevity, and Mucosal Dissemination of Immune Responses." October 2014. Full Text
  - Schifanella, L, Binello, N, Vaccari, M, Gordon, SN, Caccuri, F, Blackburn, M, Doster, M, Liynage, N, Pegu, P, Shen, X, Tomaras, GD, Venzon, D, Stablien, D, Barnett, SW, Barouch, D, Phogat, S, and Franchini, G. "Plasmablast Phenotype and Mucosal Antibodies to V2 in Vaccine-induced Protection Against SIVmac251." October 2014. Full Text
  - Shen, X, Williams, W, Yates, N, Francica, J, Reimann, K, Montefiori, D, McElrath, J, Seder, R, and Tomaras, G. "HIV ENV-SPECIFIC IGG3 RESPONSES ARE DIFFERENTIALLY ELICITED IN NONHUMAN PRIMATE BY ENV VACCINES WITH DIFFERENT ADJUVANTS." October 2014. Link to Item
  - Vaccari, M, Gordon, SN, Fourati, S, Schifanella, L, Cameron, M, Keele, BF, Shen, X, Tomaras, G, Billings, E, Rao, M, Liyanage, NP, Vargas-Inchaustegui, DA, Whitney, S, Doster, MN, Binello, N, Pegu, P, Montefiori, DC, Foulds, K, Quinn, DS, Donaldson, M, Liang, F, Lore, K, Roederer, M, Koup, R, McDermott, A, Ma, ZM, Christopher, M, Phan, TB, Forthal, DN, Blackburn, M, Caccuri, F, Ferrari, G, Robert-Guroff, M, Ratto-Kim, S, Kim, J, Michael, N, Phogat, S, Barnett, SW, Tartaglia, J, Venzon, D, Stablein, DM, Sekaly, RP, and Franchini, G. "Adjuvant Dependent Mucosal V2 Responses and RAS Activation in Vaccine Induced Protection from SIVmac251 Acquisition." October 2014. Full Text
  - Blasi, M, Negri, D, Santra, S, Parks, R, Shen, X, Tomaras, G, Permar, S, Montefiori, D, LaBranche, C, Ferrari, G, Alam, M, Liao, H, Moody, AM, Haynes, BF, Klotman, ME, and Cara, A. "A Single Immunization with Integrase Defective Lentiviral Vector Expressing gp140 Induces Persistent and Functional Immune Response in Rhesus Monkeys." Conference on AIDS Vaccine. Barcelona, SPAIN. October 7, 2013 - October 10, 2013.: MARY ANN LIEBERT, INC, November 1, 2013. Link to Item
  - Gordon, SN, Vaccari, M, Doster, MN, Liyanage, NP, Pegu, P, Schifanella, L, Caccuri, F, Keele, BF, Foulds, KE, Shen, X, Tomaras, GD, Montefiori, DC, Roederer, M, Ferrari, G, Venzon, D, Stablien, D, Barouch, DH, Felber, BK, Pavlakis, GN, Michael, NL, Tartaglia, J, and Franchini, G. "Priming with Adenovirus26 Vaccines Affects ALVAC-SIV/gp120 Vaccine Efficacy Tested in a SIVmac251 Challenge Model Performed One-Month Post-Vaccination." November 1, 2013. Link to Item
  - Rolland, M, Edlefsen, PT, Gottardo, R, Montefiori, DC, Zolla-Pazner, S, Moody, A, Liao, LH, Liu, P, Tomaras, GD, Haynes, BF, Bailer, RT, Koup, RA, Mascola, JR, Shen, X, Korber, BT, Tovanabutra, S, Rerks-Ngarm, S, Nitayaphan, S, Pitisuttihum, P, Kaewkungwal, J, Robb, ML, Michael, NL, Mullins, JI, Gilbert, PB, and Kim, JH. "Genetic and Immunological Evidence for a Role of Env-V3 Antibodies in the RV144 Trial." November 1, 2013. Link to Item
  - Schifanella, L, Gordon, S, Vaccari, M, Binello, N, Caccuri, F, Blackburn, M, Fenizia, C, Doster, M, Pegu, P, Liynage, N, Shen, X, Tomaras, G, Rao, M, Ferrari, G, Venzon, D, Stablien, D, Barnett, S, Tartaglia, J, and Franchini, G. "MF59 and ALUM, in Combination with an ALVAC-SIV/gp120 Vaccine, Induce Plasmablasts that Differ in the Expression of Homing Markers." November 1, 2013. Link to Item
  - Shen, X, Howington, R, Park, H, Sadagopal, S, Kwa, S, Cope, A, Ding, S, Bolton, D, Roederer, M, Amara, R, Picker, L, Seder, R, McElrath, J, Barnett, S, Shattock, R, Felber, B, Pavlakis, G, Pantaleo, G, Montefiori, D, and Tomaras, G. "Vaccine Induced Epitope Specific Antibodies to the SIV Envelope Are Distinct from Those Induced to the HIV-1 Envelope." November 1, 2013. Link to Item
  - Vaccari, M, Gordon, SN, Doster, M, Liynage, N, Pegu, P, Schifanella, L, Keele, BF, Shen, X, Tomaras, GD, Rao, M, Montefiori, DC, Ferrari, G, Foulds, K, Roederer, M, Venzon, D, Stablein, DM, Kim, JH, Michael, NL, Phogat, S, Barnett, SW, Tartaglia, J, and Franchini, G. "Protection from SIVmac251 Acquisition by an ALVAC/SIV/gp120 Regimen Is Not Improved by the Increase of Anti-Envelope Antibodies and T Cell Responses." November 1, 2013. Link to Item
  - Zhu, Z, Qin, HR, Chen, W, Zhao, Q, Shen, X, Schutte, R, Wang, Y, Ofek, G, Streaker, E, Prabakaran, P, Fouda, GG, Liao, H, Owens, J, Louder, M, Yang, Y, Klaric, K, Moody, MA, Mascola, JR, Scott, JK, Kwong, PD, Montefiori, D, Haynes, BF, Tomaras, GD, and Dimitrov, DS. "2F5-like Cross-Reactive HIV-1-Neutralizing Monoclonal Antibodies with Low Number of Somatic Mutations." October 2011. Link to Item
  - Tomaras, G, Binley, J, Gray, E, Shen, X, Moore, P, Decker, J, Yates, N, Haynes, B, Cohen, M, Shaw, G, Montefiori, D, Mascola, J, Morris, L, Team, CHAVI, and Team, CAVD-CAVIMC. "Epitope Specificities of Elite Neutralizing Sera from HIV-1-Infected Individuals." October 2010. Link to Item
  - Yates, N, Shen, X, Liu, P, Barnett, S, Spearman, P, Lu, S, Ferrari, G, Alam, M, Overman, R, Lucas, J, Ashley, V, Vaine, M, Wang, S, Liao, H, Hural, J, Weinhold, K, McElrath, J, Haynes, B, Montefiori, D, and Tomaras, G. "Vaccine-Elicited IgG Subclasses and Functional Antibodies." October 2010. Link to Item
  - Zhu, Z, Qin, HR, Chen, W, Zhao, Q, Fouda, G, Schutte, R, Shen, X, Liao, H, Ofek, G, Owens, J, Streaker, E, Wang, Y, Kwong, PD, Montefiori, DC, Haynes, BF, Tomaras, GD, and Dimitrov, DS. "New broadly neutralizing human monoclonal antibodies targeting the 2F5 epitope." October 2010. Link to Item
  - Shen, X, Dennison, M, Gao, F, Montefiori, DC, Verkoczy, L, Haynes, B, Alam, M, and Tomaras, G. "OA021-04. HIV-1 gp41 envelope MPER mutation altered epitope conformation in lipid and increased sensitivity to 2F5 and 4E10 neutralizing antibodies." October 22, 2009. Full Text
  - Bonsignori, M, Moody, MA, Parks, RJ, Holl, TM, Kelsoe, G, Hicks, CB, Vandergrift, N, Tomaras, GD, and Haynes, BF. "P04-48. HIV-1 envelope induces memory B cell responses that correlate with plasma antibody levels after gp120 protein vaccination or chronic HIV-1 infection." 2009.
  - Freel, SA, Chattopadhyay, PK, Lamoreaux, L, Zarkowsky, D, Overman, RG, Ochsenbauer-Jambor, C, Kappes, JC, Cunningham, CK, Denny, TN, Weinhold, KJ, Ferrari, G, Koup, RA, Graham, BS, Haynes, BF, Roederer, M, and Tomaras, GD. "S01-04 OA. Phenotypic analyses of CD8+ T cells that mediate virus inhibition from HIV-1 vaccinees and HIV-1+ virus controllers." 2009.
  - Munshaw, S, Liao, H, Dixon, A, Chen, X, Nagel, A, Derosa, K, Parks, R, Amos, J, Whitesides, JF, Marshalls, DJ, Yang, Y, Gao, F, Tomaras, GD, Moody, MA, Kelsoe, GH, Shea, TC, Margolis, DM, Markowitz, M, Goepfert, P, Shaw, G, Haynes, BF, and Kepler, TB. "S021-04 OA. A large-scale analysis of immunoglobulin sequences derived from plasmablasts/plasma cells in acute HIV-1 infection subjects." 2009.
  - Robinson, H, Amara, R, Lai, L, Xu, Y, De Rosa, S, Defawe, O, Sato, A, Tomaras, G, Qin, L, Moss, B, Wyatt, L, Hay, C, and Goepfert, P. "P19-58 LB. Comparison of the immunogenicity in humans and rhesus macaques of vaccines consisting of DNA priming and MVA boosting and MVA priming and boosting." 2009. Full Text
  - Saunders, K, Freel, S, Overman, R, Cunningham, C, and Tomaras, G. "P16-40. Inhibition of histone deacetylases modulates CD8+ T-lymphocyte mediated virus suppression by HIV-1 viral controllers." 2009. Full Text
  - Shen, X, Dennison, M, Gao, F, Montefiori, D, Verkoczy, L, Haynes, B, Alam, M, and Tomaras, G. "OA021-04. HIV-1 gp41 envelope MPER mutation altered epitope conformation in lipid and increased sensitivity to 2F5 and 4E10 neutralizing antibodies." 2009. Full Text
  - Shen, X, Montefiori, D, Parks, R, Haynes, BF, and Tomaras, GT. "2F5-Like Antibody Identified from an HIV-Infected Patient Concurrent with the Development of Autoimmune Antibodies." October 2008. Link to Item
- Journal Articles
  - Ackerman, ME, Das, J, Pittala, S, Broge, T, Linde, C, Suscovich, TJ, Brown, EP, Bradley, T, Natarajan, H, Lin, S, Sassic, JK, O'Keefe, S, Mehta, N, Goodman, D, Sips, M, Weiner, JA, Tomaras, GD, Haynes, BF, Lauffenburger, DA, Bailey-Kellogg, C, Roederer, M, and Alter, G. "Route of immunization defines multiple mechanisms of vaccine-mediated protection against SIV." Nature Medicine 24, no. 10 (October 2018): 1590-1598. Full Text
  - Phillips, B, Van Rompay, KKA, Rodriguez-Nieves, J, Lorin, C, Koutsoukos, M, Tomai, M, Fox, CB, Eudailey, J, Dennis, M, Alam, SM, Hudgens, M, Fouda, G, Pollara, J, Moody, A, Shen, X, Ferrari, G, Permar, S, and De Paris, K. "Adjuvant-Dependent Enhancement of HIV Env-Specific Antibody Responses in Infant Rhesus Macaques." Journal of Virology 92, no. 20 (October 2018). Full Text
  - Bar-On, Y, Gruell, H, Schoofs, T, Pai, JA, Nogueira, L, Butler, AL, Millard, K, Lehmann, C, Suárez, I, Oliveira, TY, Karagounis, T, Cohen, YZ, Wyen, C, Scholten, S, Handl, L, Belblidia, S, Dizon, JP, Vehreschild, JJ, Witmer-Pack, M, Shimeliovich, I, Jain, K, Fiddike, K, Seaton, KE, Yates, NL, Horowitz, J, Gulick, RM, Pfeifer, N, Tomaras, GD, Seaman, MS, Fätkenheuer, G, Caskey, M, Klein, F, and Nussenzweig, MC. "Safety and antiviral activity of combination HIV-1 broadly neutralizing antibodies in viremic individuals." Nature Medicine (September 26, 2018). Full Text
  - Mendoza, P, Gruell, H, Nogueira, L, Pai, JA, Butler, AL, Millard, K, Lehmann, C, Suárez, I, Oliveira, TY, Lorenzi, JCC, Cohen, YZ, Wyen, C, Kümmerle, T, Karagounis, T, Lu, C-L, Handl, L, Unson-O'Brien, C, Patel, R, Ruping, C, Schlotz, M, Witmer-Pack, M, Shimeliovich, I, Kremer, G, Thomas, E, Seaton, KE, Horowitz, J, West, AP, Bjorkman, PJ, Tomaras, GD, Gulick, RM, Pfeifer, N, Fätkenheuer, G, Seaman, MS, Klein, F, Caskey, M, and Nussenzweig, MC. "Combination therapy with anti-HIV-1 antibodies maintains viral suppression." Nature 561, no. 7724 (September 26, 2018): 479-484. Full Text
  - Dennison, SM, Reichartz, M, Seaton, KE, Dutta, S, Wille-Reece, U, Hill, AVS, Ewer, KJ, Rountree, W, Sarzotti-Kelsoe, M, Ozaki, DA, Alam, SM, and Tomaras, GD. "Qualified Biolayer Interferometry Avidity Measurements Distinguish the Heterogeneity of Antibody Interactions with Plasmodium falciparum Circumsporozoite Protein Antigens." Journal of Immunology (Baltimore, Md. : 1950) 201, no. 4 (August 2018): 1315-1326. Full Text
  - Singh, S, Ramírez-Salazar, EG, Doueiri, R, Valentin, A, Rosati, M, Hu, X, Keele, BF, Shen, X, Tomaras, GD, Ferrari, G, LaBranche, C, Montefiori, DC, Das, J, Alter, G, Trinh, HV, Hamlin, C, Rao, M, Dayton, F, Bear, J, Chowdhury, B, Alicea, C, Lifson, JD, Broderick, KE, Sardesai, NY, Sivananthan, SJ, Fox, CB, Reed, SG, Venzon, DJ, Hirsch, VM, Pavlakis, GN, and Felber, BK. "Control of Heterologous Simian Immunodeficiency Virus SIVsmE660 Infection by DNA and Protein Coimmunization Regimens Combined with Different Toll-Like-Receptor-4-Based Adjuvants in Macaques." Journal of Virology 92, no. 15 (August 2018). Full Text
  - Barouch, DH, Tomaka, FL, Wegmann, F, Stieh, DJ, Alter, G, Robb, ML, Michael, NL, Peter, L, Nkolola, JP, Borducchi, EN, Chandrashekar, A, Jetton, D, Stephenson, KE, Li, W, Korber, B, Tomaras, GD, Montefiori, DC, Gray, G, Frahm, N, McElrath, MJ, Baden, L, Johnson, J, Hutter, J, Swann, E, Karita, E, Kibuuka, H, Mpendo, J, Garrett, N, Mngadi, K, Chinyenze, K, Priddy, F, Lazarus, E, Laher, F, Nitayapan, S, Pitisuttithum, P, Bart, S, Campbell, T, Feldman, R, Lucksinger, G, Borremans, C, Callewaert, K, Roten, R, Sadoff, J, Scheppler, L, Weijtens, M, Feddes-de Boer, K, van Manen, D, Vreugdenhil, J, Zahn, R, Lavreys, L, Nijs, S, Tolboom, J, Hendriks, J, Euler, Z, Pau, MG, and Schuitemaker, H. "Evaluation of a mosaic HIV-1 vaccine in a multicentre, randomised, double-blind, placebo-controlled, phase 1/2a clinical trial (APPROACH) and in rhesus monkeys (NHP 13-19)." Lancet (London, England) 392, no. 10143 (July 6, 2018): 232-243. Full Text
  - Bekker, L-G, Moodie, Z, Grunenberg, N, Laher, F, Tomaras, GD, Cohen, KW, Allen, M, Malahleha, M, Mngadi, K, Daniels, B, Innes, C, Bentley, C, Frahm, N, Morris, DE, Morris, L, Mkhize, NN, Montefiori, DC, Sarzotti-Kelsoe, M, Grant, S, Yu, C, Mehra, VL, Pensiero, MN, Phogat, S, DiazGranados, CA, Barnett, SW, Kanesa-Thasan, N, Koutsoukos, M, Michael, NL, Robb, ML, Kublin, JG, Gilbert, PB, Corey, L, Gray, GE, McElrath, MJ, and HVTN 100 Protocol Team, . "Subtype C ALVAC-HIV and bivalent subtype C gp120/MF59 HIV-1 vaccine in low-risk, HIV-uninfected, South African adults: a phase 1/2 trial." The Lancet. Hiv 5, no. 7 (July 2018): e366-e378. Full Text
  - Vaccari, M, Fourati, S, Gordon, SN, Brown, DR, Bissa, M, Schifanella, L, Silva de Castro, I, Doster, MN, Galli, V, Omsland, M, Fujikawa, D, Gorini, G, Liyanage, NPM, Trinh, HV, McKinnon, KM, Foulds, KE, Keele, BF, Roederer, M, Koup, RA, Shen, X, Tomaras, GD, Wong, MP, Munoz, KJ, Gach, JS, Forthal, DN, Montefiori, DC, Venzon, DJ, Felber, BK, Rosati, M, Pavlakis, GN, Rao, M, Sekaly, R-P, and Franchini, G. "HIV vaccine candidate activation of hypoxia and the inflammasome in CD14+ monocytes is associated with a decreased risk of SIVmac251 acquisition." Nature Medicine 24, no. 6 (June 2018): 847-856. Full Text
  - Schiffner, T, Pallesen, J, Russell, RA, Dodd, J, de Val, N, LaBranche, CC, Montefiori, D, Tomaras, GD, Shen, X, Harris, SL, Moghaddam, AE, Kalyuzhniy, O, Sanders, RW, McCoy, LE, Moore, JP, Ward, AB, and Sattentau, QJ. "Structural and immunologic correlates of chemically stabilized HIV-1 envelope glycoproteins." Plos Pathogens 14, no. 5 (May 10, 2018): e1006986-null. Full Text
  - Pollara, J, Orlandi, C, Beck, C, Edwards, RW, Hu, Y, Liu, S, Wang, S, Koup, RA, Denny, TN, Lu, S, Tomaras, GD, DeVico, A, Lewis, GK, and Ferrari, G. "Application of area scaling analysis to identify natural killer cell and monocyte involvement in the GranToxiLux antibody dependent cell-mediated cytotoxicity assay." Cytometry. Part a : the Journal of the International Society for Analytical Cytology 93, no. 4 (April 2018): 436-447. Full Text
  - Saunders, KO, Santra, S, Parks, R, Yates, NL, Sutherland, LL, Scearce, RM, Balachandran, H, Bradley, T, Goodman, D, Eaton, A, Stanfield-Oakley, SA, Tartaglia, J, Phogat, S, Pantaleo, G, Esteban, M, Gomez, CE, Perdiguero, B, Jacobs, B, Kibler, K, Korber, B, Montefiori, DC, Ferrari, G, Vandergrift, N, Liao, H-X, Tomaras, GD, and Haynes, BF. "Immunogenicity of NYVAC Prime-Protein Boost Human Immunodeficiency Virus Type 1 Envelope Vaccination and Simian-Human Immunodeficiency Virus Challenge of Nonhuman Primates." Journal of Virology 92, no. 8 (April 2018). Full Text
  - Wills, S, Hwang, K-K, Liu, P, Dennison, SM, Tay, MZ, Shen, X, Pollara, J, Lucas, JT, Parks, R, Rerks-Ngarm, S, Pitisuttithum, P, Nitayapan, S, Kaewkungwal, J, Thomas, R, Kim, JH, Michael, NL, Robb, ML, McRaven, M, Montefiori, DC, Hope, TJ, Liao, H-X, Moody, MA, Ferrari, G, Haynes, BF, Alam, SM, Bonsignori, M, and Tomaras, GD. "HIV-1-Specific IgA Monoclonal Antibodies from an HIV-1 Vaccinee Mediate Galactosylceramide Blocking and Phagocytosis." Journal of Virology 92, no. 7 (April 2018). Full Text
  - Yates, NL, deCamp, AC, Korber, BT, Liao, H-X, Irene, C, Pinter, A, Peacock, J, Harris, LJ, Sawant, S, Hraber, P, Shen, X, Rerks-Ngarm, S, Pitisuttithum, P, Nitayapan, S, Berman, PW, Robb, ML, Pantaleo, G, Zolla-Pazner, S, Haynes, BF, Alam, SM, Montefiori, DC, and Tomaras, GD. "HIV-1 Envelope Glycoproteins from Diverse Clades Differentiate Antibody Responses and Durability among Vaccinees." Journal of Virology 92, no. 8 (April 2018). Full Text
  - Nguyen, QN, Martinez, DR, Himes, JE, Whitney Edwards, R, Han, Q, Kumar, A, Mangan, R, Nicely, NI, Xie, G, Vandergrift, N, Shen, X, Pollara, J, and Permar, SR. "Predominant envelope variable loop 2-specific and gp120-specific antibody-dependent cellular cytotoxicity antibody responses in acutely SIV-infected African green monkeys." Retrovirology 15, no. 1 (March 9, 2018): 24-null. Full Text
  - Fong, Y, Shen, X, Ashley, VC, Deal, A, Seaton, KE, Yu, C, Grant, SP, Ferrari, G, deCamp, AC, Bailer, RT, Koup, RA, Montefiori, D, Haynes, BF, Sarzotti-Kelsoe, M, Graham, BS, Carpp, LN, Hammer, SM, Sobieszczyk, M, Karuna, S, Swann, E, DeJesus, E, Mulligan, M, Frank, I, Buchbinder, S, Novak, RM, McElrath, MJ, Kalams, S, Keefer, M, Frahm, NA, Janes, HE, Gilbert, PB, and Tomaras, GD. "Modification of the Association Between T-Cell Immune Responses and Human Immunodeficiency Virus Type 1 Infection Risk by Vaccine-Induced Antibody Responses in the HVTN 505 Trial." The Journal of Infectious Diseases 217, no. 8 (March 2018): 1280-1288. Full Text
  - Jones, AT, Chamcha, V, Kesavardhana, S, Shen, X, Beaumont, D, Das, R, Wyatt, LS, LaBranche, CC, Stanfield-Oakley, S, Ferrari, G, Montefiori, DC, Moss, B, Tomaras, GD, Varadarajan, R, and Amara, RR. "A Trimeric HIV-1 Envelope gp120 Immunogen Induces Potent and Broad Anti-V1V2 Loop Antibodies against HIV-1 in Rabbits and Rhesus Macaques." Journal of Virology 92, no. 5 (March 2018). Full Text
  - McGuire, EP, Fong, Y, Toote, C, Cunningham, CK, McFarland, EJ, Borkowsky, W, Barnett, S, Itell, HL, Kumar, A, Gray, G, McElrath, MJ, Tomaras, GD, Permar, SR, and Fouda, GG. "HIV-Exposed Infants Vaccinated with an MF59/Recombinant gp120 Vaccine Have Higher-Magnitude Anti-V1V2 IgG Responses than Adults Immunized with the Same Vaccine." Journal of Virology 92, no. 1 (January 2018). Full Text
  - Vaidya, NK, Ribeiro, RM, Liu, P, Haynes, BF, Tomaras, GD, and Perelson, AS. "Correlation Between Anti-gp41 Antibodies and Virus Infectivity Decay During Primary HIV-1 Infection." Frontiers in Microbiology 9 (January 2018): 1326-null. Full Text
  - Wen, Y, Trinh, HV, Linton, CE, Tani, C, Norais, N, Martinez-Guzman, D, Ramesh, P, Sun, Y, Situ, F, Karaca-Griffin, S, Hamlin, C, Onkar, S, Tian, S, Hilt, S, Malyala, P, Lodaya, R, Li, N, Otten, G, Palladino, G, Friedrich, K, Aggarwal, Y, LaBranche, C, Duffy, R, Shen, X, Tomaras, GD, Montefiori, DC, Fulp, W, Gottardo, R, Burke, B, Ulmer, JB, Zolla-Pazner, S, Liao, H-X, Haynes, BF, Michael, NL, Kim, JH, Rao, M, O'Connell, RJ, Carfi, A, and Barnett, SW. "Generation and characterization of a bivalent protein boost for future clinical trials: HIV-1 subtypes CR01_AE and B gp120 antigens with a potent adjuvant." Plos One 13, no. 4 (January 2018): e0194266-null. Full Text
  - Seaton, KE, Vandergrift, NA, Deal, AW, Rountree, W, Bainbridge, J, Grebe, E, Anderson, DA, Sawant, S, Shen, X, Yates, NL, Denny, TN, Liao, H-X, Haynes, BF, Robb, ML, Parkin, N, Santos, BR, Garrett, N, Price, MA, Naniche, D, Duerr, AC, CEPHIA group, , Keating, S, Hampton, D, Facente, S, Marson, K, Welte, A, Pilcher, CD, Cohen, MS, and Tomaras, GD. "Computational analysis of antibody dynamics identifies recent HIV-1 infection." JCI insight 2, no. 24 (December 21, 2017). Full Text
  - Saunders, KO, Verkoczy, LK, Jiang, C, Zhang, J, Parks, R, Chen, H, Housman, M, Bouton-Verville, H, Shen, X, Trama, AM, Scearce, R, Sutherland, L, Santra, S, Newman, A, Eaton, A, Xu, K, Georgiev, IS, Joyce, MG, Tomaras, GD, Bonsignori, M, Reed, SG, Salazar, A, Mascola, JR, Moody, MA, Cain, DW, Centlivre, M, Zurawski, S, Zurawski, G, Erickson, HP, Kwong, PD, Alam, SM, Levy, Y, Montefiori, DC, and Haynes, BF. "Vaccine Induction of Heterologous Tier 2 HIV-1 Neutralizing Antibodies in Animal Models." Cell Reports 21, no. 13 (December 2017): 3681-3690. Full Text
  - Shen, X, Basu, R, Sawant, S, Beaumont, D, Kwa, SF, LaBranche, C, Seaton, KE, Yates, NL, Montefiori, DC, Ferrari, G, Wyatt, LS, Moss, B, Alam, SM, Haynes, BF, Tomaras, GD, and Robinson, HL. "HIV-1 gp120 and Modified Vaccinia Virus Ankara (MVA) gp140 Boost Immunogens Increase Immunogenicity of a DNA/MVA HIV-1 Vaccine." Journal of Virology 91, no. 24 (December 2017). Full Text
  - Mayer, KH, Seaton, KE, Huang, Y, Grunenberg, N, Isaacs, A, Allen, M, Ledgerwood, JE, Frank, I, Sobieszczyk, ME, Baden, LR, Rodriguez, B, Van Tieu, H, Tomaras, GD, Deal, A, Goodman, D, Bailer, RT, Ferrari, G, Jensen, R, Hural, J, Graham, BS, Mascola, JR, Corey, L, Montefiori, DC, HVTN 104 Protocol Team, , and and the NIAID HIV Vaccine Trials Network, . "Safety, pharmacokinetics, and immunological activities of multiple intravenous or subcutaneous doses of an anti-HIV monoclonal antibody, VRC01, administered to HIV-uninfected adults: Results of a phase 1 randomized trial." Plos Medicine 14, no. 11 (November 14, 2017): e1002435-null. Full Text
  - Li, SS, Kochar, NK, Elizaga, M, Hay, CM, Wilson, GJ, Cohen, KW, De Rosa, SC, Xu, R, Ota-Setlik, A, Morris, D, Finak, G, Allen, M, Tieu, H-V, Frank, I, Sobieszczyk, ME, Hannaman, D, Gottardo, R, Gilbert, PB, Tomaras, GD, Corey, L, Clarke, DK, Egan, MA, Eldridge, JH, McElrath, MJ, Frahm, N, and NIAID HIV Vaccine Trials Network, . "DNA Priming Increases Frequency of T-Cell Responses to a Vesicular Stomatitis Virus HIV Vaccine with Specific Enhancement of CD8+ T-Cell Responses by Interleukin-12 Plasmid DNA." Clinical and Vaccine Immunology : Cvi 24, no. 11 (November 6, 2017). Full Text
  - Han, Q, Williams, WB, Saunders, KO, Seaton, KE, Wiehe, KJ, Vandergrift, N, Von Holle, TA, Trama, AM, Parks, RJ, Luo, K, Gurley, TC, Kepler, TB, Marshall, DJ, Montefiori, DC, Sutherland, LL, Alam, MS, Whitesides, JF, Bowman, CM, Permar, SR, Graham, BS, Mascola, JR, Seed, PC, Van Rompay, KKA, Tomaras, GD, Moody, MA, and Haynes, BF. "HIV DNA-Adenovirus Multiclade Envelope Vaccine Induces gp41 Antibody Immunodominance in Rhesus Macaques." Journal of Virology 91, no. 21 (November 2017). Full Text
  - Phillips, B, Fouda, GG, Eudailey, J, Pollara, J, Curtis, AD, Kunz, E, Dennis, M, Shen, X, Bay, C, Hudgens, M, Pickup, D, Alam, SM, Ardeshir, A, Kozlowski, PA, Van Rompay, KKA, Ferrari, G, Moody, MA, Permar, S, and De Paris, K. "Impact of Poxvirus Vector Priming, Protein Coadministration, and Vaccine Intervals on HIV gp120 Vaccine-Elicited Antibody Magnitude and Function in Infant Macaques." Clinical and Vaccine Immunology : Cvi 24, no. 10 (October 5, 2017). Full Text
  - Shen, X, Bogers, WM, Yates, NL, Ferrari, G, Dey, AK, Williams, WT, Jaeger, FH, Wiehe, K, Sawant, S, Alam, SM, LaBranche, CC, Montefiori, DC, Martin, L, Srivastava, I, Heeney, J, Barnett, SW, and Tomaras, GD. "Cross-Linking of a CD4-Mimetic Miniprotein with HIV-1 Env gp140 Alters Kinetics and Specificities of Antibody Responses against HIV-1 Env in Macaques." Journal of Virology 91, no. 19 (October 2017). Full Text
  - Wang, K, Tomaras, GD, Jegaskanda, S, Moody, MA, Liao, H-X, Goodman, KN, Berman, PW, Rerks-Ngarm, S, Pitisuttithum, P, Nitayapan, S, Kaewkungwal, J, Haynes, BF, and Cohen, JI. "Monoclonal Antibodies, Derived from Humans Vaccinated with the RV144 HIV Vaccine Containing the HVEM Binding Domain of Herpes Simplex Virus (HSV) Glycoprotein D, Neutralize HSV Infection, Mediate Antibody-Dependent Cellular Cytotoxicity, and Protect Mice from Ocular Challenge with HSV-1." Journal of Virology 91, no. 19 (October 2017). Full Text
  - Bradley, T, Pollara, J, Santra, S, Vandergrift, N, Pittala, S, Bailey-Kellogg, C, Shen, X, Parks, R, Goodman, D, Eaton, A, Balachandran, H, Mach, LV, Saunders, KO, Weiner, JA, Scearce, R, Sutherland, LL, Phogat, S, Tartaglia, J, Reed, SG, Hu, S-L, Theis, JF, Pinter, A, Montefiori, DC, Kepler, TB, Peachman, KK, Rao, M, Michael, NL, Suscovich, TJ, Alter, G, Ackerman, ME, Moody, MA, Liao, H-X, Tomaras, G, Ferrari, G, Korber, BT, and Haynes, BF. "Pentavalent HIV-1 vaccine protects against simian-human immunodeficiency virus challenge." Nature Communications 8 (June 8, 2017): 15711-null. Full Text
  - Zurawski, G, Shen, X, Zurawski, S, Tomaras, GD, Montefiori, DC, Roederer, M, Ferrari, G, Lacabaratz, C, Klucar, P, Wang, Z, Foulds, KE, Kao, S-F, Yu, X, Sato, A, Yates, NL, LaBranche, C, Stanfield-Oakley, S, Kibler, K, Jacobs, B, Salazar, A, Self, S, Fulp, W, Gottardo, R, Galmin, L, Weiss, D, Cristillo, A, Pantaleo, G, and Levy, Y. "Superiority in Rhesus Macaques of Targeting HIV-1 Env gp140 to CD40 versus LOX-1 in Combination with Replication-Competent NYVAC-KC for Induction of Env-Specific Antibody and T Cell Responses." Journal of Virology 91, no. 9 (May 2017). Full Text
  - Ferrari, G, Pollara, J, Tomaras, GD, and Haynes, BF. "Humoral and Innate Antiviral Immunity as Tools to Clear Persistent HIV Infection." The Journal of Infectious Diseases 215, no. suppl_3 (March 2017): S152-S159. (Review) Full Text
  - Wiehe, K, Nicely, NI, Lockwood, B, Kuraoka, M, Anasti, K, Arora, S, Bowman, CM, Stolarchuk, C, Parks, R, Lloyd, KE, Xia, S-M, Duffy, R, Shen, X, Kyratsous, CA, Macdonald, LE, Murphy, AJ, Scearce, RM, Moody, MA, Alam, SM, Verkoczy, L, Tomaras, GD, Kelsoe, G, and Haynes, BF. "Immunodominance of Antibody Recognition of the HIV Envelope V2 Region in Ig-Humanized Mice." Journal of Immunology (Baltimore, Md. : 1950) 198, no. 3 (February 2017): 1047-1055. Full Text
  - Chang, WLW, Gonzalez, DF, Kieu, HT, Castillo, LD, Messaoudi, I, Shen, X, Tomaras, GD, Shacklett, BL, Barry, PA, and Sparger, EE. "Changes in Circulating B Cell Subsets Associated with Aging and Acute SIV Infection in Rhesus Macaques." Plos One 12, no. 1 (January 17, 2017): e0170154-null. Full Text
  - Ramesh, A, Darko, S, Hua, A, Overman, G, Ransier, A, Francica, JR, Trama, A, Tomaras, GD, Haynes, BF, Douek, DC, and Kepler, TB. "Structure and Diversity of the Rhesus Macaque Immunoglobulin Loci through Multiple De Novo Genome Assemblies." Frontiers in immunology 8 (January 2017): 1407-. Full Text
  - Tomaras, GD, and Plotkin, SA. "Complex immune correlates of protection in HIV-1 vaccine efficacy trials." Immunological Reviews 275, no. 1 (January 2017): 245-261. (Review) Full Text
  - deCamp, AC, Rolland, M, Edlefsen, PT, Sanders-Buell, E, Hall, B, Magaret, CA, Fiore-Gartland, AJ, Juraska, M, Carpp, LN, Karuna, ST, Bose, M, LePore, S, Miller, S, O'Sullivan, A, Poltavee, K, Bai, H, Dommaraju, K, Zhao, H, Wong, K, Chen, L, Ahmed, H, Goodman, D, Tay, MZ, Gottardo, R, Koup, RA, Bailer, R, Mascola, JR, Graham, BS, Roederer, M, O'Connell, RJ, Michael, NL, Robb, ML, Adams, E, D'Souza, P, Kublin, J, Corey, L, Geraghty, DE, Frahm, N, Tomaras, GD, McElrath, MJ, Frenkel, L, Styrchak, S, Tovanabutra, S, Sobieszczyk, ME, Hammer, SM, Kim, JH, Mullins, JI, and Gilbert, PB. "Sieve analysis of breakthrough HIV-1 sequences in HVTN 505 identifies vaccine pressure targeting the CD4 binding site of Env-gp120." Plos One 12, no. 11 (January 2017): e0185959-null. Full Text
  - Ferrari, G, Haynes, BF, Koenig, S, Nordstrom, JL, Margolis, DM, and Tomaras, GD. "Envelope-specific antibodies and antibody-derived molecules for treating and curing HIV infection." Nature Reviews. Drug Discovery 15, no. 12 (December 2016): 823-834. (Review) Full Text
  - Negri, D, Blasi, M, LaBranche, C, Parks, R, Balachandran, H, Lifton, M, Shen, X, Denny, T, Ferrari, G, Vescio, MF, Andersen, H, Montefiori, DC, Tomaras, GD, Liao, H-X, Santra, S, Haynes, BF, Klotman, ME, and Cara, A. "Immunization with an SIV-based IDLV Expressing HIV-1 Env 1086 Clade C Elicits Durable Humoral and Cellular Responses in Rhesus Macaques." Molecular Therapy : the Journal of the American Society of Gene Therapy 24, no. 11 (November 2016): 2021-2032. Full Text Open Access Copy
  - Negri, D, Blasi, M, LaBranche, C, Parks, R, Balachandran, H, Lifton, M, Shen, X, Denny, T, Ferrari, G, Vescio, MF, Andersen, H, Montefiori, DC, Tomaras, GD, Liao, H-X, Santra, S, Haynes, BF, Klotman, ME, and Cara, A. "Immunization with an SIV-based IDLV Expressing HIV-1 Env 1086 Clade C Elicits Durable Humoral and Cellular Responses in Rhesus Macaques." MOLECULAR THERAPY 24, no. 11 (November 2016): 2021-2032. Full Text Open Access Copy Link to Item
  - Andersson, A-MC, Ragonnaud, E, Seaton, KE, Sawant, S, Folgori, A, Colloca, S, Labranche, C, Montefiori, DC, Tomaras, GD, and Holst, PJ. "Effect of HIV-1 envelope cytoplasmic tail on adenovirus primed virus encoded virus-like particle immunizations." Vaccine 34, no. 44 (October 2016): 5344-5351. Full Text
  - Gordon, SN, Liyanage, NPM, Doster, MN, Vaccari, M, Vargas-Inchaustegui, DA, Pegu, P, Schifanella, L, Shen, X, Tomaras, GD, Rao, M, Billings, EA, Schwartz, J, Prado, I, Bobb, K, Zhang, W, Montefiori, DC, Foulds, KE, Ferrari, G, Robert-Guroff, M, Roederer, M, Phan, TB, Forthal, DN, Stablein, DM, Phogat, S, Venzon, DJ, Fouts, T, and Franchini, G. "Boosting of ALVAC-SIV Vaccine-Primed Macaques with the CD4-SIVgp120 Fusion Protein Elicits Antibodies to V2 Associated with a Decreased Risk of SIVmac251 Acquisition." Journal of Immunology (Baltimore, Md. : 1950) 197, no. 7 (October 2016): 2726-2737. Full Text
  - Iyer, SS, Gangadhara, S, Victor, B, Shen, X, Chen, X, Nabi, R, Kasturi, SP, Sabula, MJ, Labranche, CC, Reddy, PBJ, Tomaras, GD, Montefiori, DC, Moss, B, Spearman, P, Pulendran, B, Kozlowski, PA, and Amara, RR. "Virus-Like Particles Displaying Trimeric Simian Immunodeficiency Virus (SIV) Envelope gp160 Enhance the Breadth of DNA/Modified Vaccinia Virus Ankara SIV Vaccine-Induced Antibody Responses in Rhesus Macaques." Journal of Virology 90, no. 19 (October 2016): 8842-8854. Full Text
  - Safrit, JT, Tomaras, GD, Hanke, T, deCamp, AC, and Voronin, Y. "The Landscape of Targeted Immune Responses in the HIV-1 Vaccine Field." Aids Research and Human Retroviruses 32, no. 10-11 (October 2016): 944-946. (Letter) Full Text
  - Townsley, S, Mohamed, Z, Guo, W, McKenna, J, Cleveland, B, LaBranche, C, Beaumont, D, Shen, X, Yates, NL, Pinter, A, Tomaras, GD, Ferrari, G, Montefiori, DC, and Hu, S-L. "Induction of Heterologous Tier 2 HIV-1-Neutralizing and Cross-Reactive V1/V2-Specific Antibodies in Rabbits by Prime-Boost Immunization." Journal of Virology 90, no. 19 (October 2016): 8644-8660. Full Text
  - Vaccari, M, Gordon, SN, Fourati, S, Schifanella, L, Liyanage, NPM, Cameron, M, Keele, BF, Shen, X, Tomaras, GD, Billings, E, Rao, M, Chung, AW, Dowell, KG, Bailey-Kellogg, C, Brown, EP, Ackerman, ME, Vargas-Inchaustegui, DA, Whitney, S, Doster, MN, Binello, N, Pegu, P, Montefiori, DC, Foulds, K, Quinn, DS, Donaldson, M, Liang, F, Loré, K, Roederer, M, Koup, RA, McDermott, A, Ma, Z-M, Miller, CJ, Phan, TB, Forthal, DN, Blackburn, M, Caccuri, F, Bissa, M, Ferrari, G, Kalyanaraman, V, Ferrari, MG, Thompson, D, Robert-Guroff, M, Ratto-Kim, S, Kim, JH, Michael, NL, Phogat, S, Barnett, SW, Tartaglia, J, Venzon, D, Stablein, DM, Alter, G, Sekaly, R-P, and Franchini, G. "Corrigendum: Adjuvant-dependent innate and adaptive immune signatures of risk of SIVmac251 acquisition." Nature Medicine 22, no. 10 (October 2016): 1192-null. Full Text
  - Abdulhaqq, SA, Zorrilla, C, Kang, G, Yin, X, Tamayo, V, Seaton, KE, Joseph, J, Garced, S, Tomaras, GD, Linn, KA, Foulkes, AS, Azzoni, L, VerMilyea, M, Coutifaris, C, Kossenkov, AV, Showe, L, Kraiselburd, EN, Li, Q, and Montaner, LJ. "HIV-1-negative female sex workers sustain high cervical IFNɛ, low immune activation, and low expression of HIV-1-required host genes." Mucosal Immunology 9, no. 4 (July 2016): 1027-1038. Full Text
  - Vaccari, M, Gordon, SN, Fourati, S, Schifanella, L, Liyanage, NPM, Cameron, M, Keele, BF, Shen, X, Tomaras, GD, Billings, E, Rao, M, Chung, AW, Dowell, KG, Bailey-Kellogg, C, Brown, EP, Ackerman, ME, Vargas-Inchaustegui, DA, Whitney, S, Doster, MN, Binello, N, Pegu, P, Montefiori, DC, Foulds, K, Quinn, DS, Donaldson, M, Liang, F, Loré, K, Roederer, M, Koup, RA, McDermott, A, Ma, Z-M, Miller, CJ, Phan, TB, Forthal, DN, Blackburn, M, Caccuri, F, Bissa, M, Ferrari, G, Kalyanaraman, V, Ferrari, MG, Thompson, D, Robert-Guroff, M, Ratto-Kim, S, Kim, JH, Michael, NL, Phogat, S, Barnett, SW, Tartaglia, J, Venzon, D, Stablein, DM, Alter, G, Sekaly, R-P, and Franchini, G. "Adjuvant-dependent innate and adaptive immune signatures of risk of SIVmac251 acquisition." Nature Medicine 22, no. 7 (July 2016): 762-770. Full Text
  - Gray, GE, Mayer, KH, Elizaga, ML, Bekker, L-G, Allen, M, Morris, L, Montefiori, D, De Rosa, SC, Sato, A, Gu, N, Tomaras, GD, Tucker, T, Barnett, SW, Mkhize, NN, Shen, X, Downing, K, Williamson, C, Pensiero, M, Corey, L, and Williamson, A-L. "Subtype C gp140 Vaccine Boosts Immune Responses Primed by the South African AIDS Vaccine Initiative DNA-C2 and MVA-C HIV Vaccines after More than a 2-Year Gap." Clinical and Vaccine Immunology : Cvi 23, no. 6 (June 6, 2016): 496-506. Full Text
  - Le Grand, R, Dereuddre-Bosquet, N, Dispinseri, S, Gosse, L, Desjardins, D, Shen, X, Tolazzi, M, Ochsenbauer, C, Saidi, H, Tomaras, G, Prague, M, Barnett, SW, Thiebaut, R, Cope, A, Scarlatti, G, and Shattock, RJ. "Superior Efficacy of a Human Immunodeficiency Virus Vaccine Combined with Antiretroviral Prevention in Simian-Human Immunodeficiency Virus-Challenged Nonhuman Primates." Journal of Virology 90, no. 11 (June 2016): 5315-5328. Full Text
  - Li, H, Wang, S, Kong, R, Ding, W, Lee, F-H, Parker, Z, Kim, E, Learn, GH, Hahn, P, Policicchio, B, Brocca-Cofano, E, Deleage, C, Hao, X, Chuang, G-Y, Gorman, J, Gardner, M, Lewis, MG, Hatziioannou, T, Santra, S, Apetrei, C, Pandrea, I, Alam, SM, Liao, H-X, Shen, X, Tomaras, GD, Farzan, M, Chertova, E, Keele, BF, Estes, JD, Lifson, JD, Doms, RW, Montefiori, DC, Haynes, BF, Sodroski, JG, Kwong, PD, Hahn, BH, and Shaw, GM. "Envelope residue 375 substitutions in simian-human immunodeficiency viruses enhance CD4 binding and replication in rhesus macaques." Proceedings of the National Academy of Sciences of the United States of America 113, no. 24 (June 2016): E3413-E3422. Full Text
  - O'Connell, RJ, Excler, J-L, Polonis, VR, Ratto-Kim, S, Cox, J, Jagodzinski, LL, Liu, M, Wieczorek, L, McNeil, JG, El-Habib, R, Michael, NL, Gilliam, BL, Paris, R, VanCott, TC, Tomaras, GD, Birx, DL, Robb, ML, and Kim, JH. "Safety and Immunogenicity of a Randomized Phase 1 Prime-Boost Trial With ALVAC-HIV (vCP205) and Oligomeric Glycoprotein 160 From HIV-1 Strains MN and LAI-2 Adjuvanted in Alum or Polyphosphazene." The Journal of infectious diseases 213, no. 12 (June 2016): 1946-1954. Full Text
  - Archary, D, Seaton, KE, Passmore, JS, Werner, L, Deal, A, Dunphy, LJ, Arnold, KB, Yates, NL, Lauffenburger, DA, Bergin, P, Liebenberg, LJ, Samsunder, N, Mureithi, MW, Altfeld, M, Garrett, N, Abdool Karim, Q, Abdool Karim, SS, Morris, L, and Tomaras, GD. "Erratum: Distinct genital tract HIV-specific antibody profiles associated with tenofovir gel." Mucosal Immunology 9, no. 3 (May 2016): 834-834. Full Text
  - Nelson, CS, Pollara, J, Kunz, EL, Jeffries, TL, Duffy, R, Beck, C, Stamper, L, Wang, M, Shen, X, Pickup, DJ, Staats, HF, Hudgens, MG, Kepler, TB, Montefiori, DC, Moody, MA, Tomaras, GD, Liao, H-X, Haynes, BF, Ferrari, G, Fouda, GGA, and Permar, SR. "Combined HIV-1 Envelope Systemic and Mucosal Immunization of Lactating Rhesus Monkeys Induces a Robust Immunoglobulin A Isotype B Cell Response in Breast Milk." Journal of Virology 90, no. 10 (May 2016): 4951-4965. Full Text
  - Asbach, B, Kliche, A, Köstler, J, Perdiguero, B, Esteban, M, Jacobs, BL, Montefiori, DC, LaBranche, CC, Yates, NL, Tomaras, GD, Ferrari, G, Foulds, KE, Roederer, M, Landucci, G, Forthal, DN, Seaman, MS, Hawkins, N, Self, SG, Sato, A, Gottardo, R, Phogat, S, Tartaglia, J, Barnett, SW, Burke, B, Cristillo, AD, Weiss, DE, Francis, J, Galmin, L, Ding, S, Heeney, JL, Pantaleo, G, and Wagner, R. "Potential To Streamline Heterologous DNA Prime and NYVAC/Protein Boost HIV Vaccine Regimens in Rhesus Macaques by Employing Improved Antigens." Journal of Virology 90, no. 8 (April 2016): 4133-4149. Full Text Open Access Copy
  - Huang, Y, DiazGranados, C, Janes, H, Huang, Y, deCamp, AC, Metch, B, Grant, S, Sanchez, B, Phogat, S, Koutsoukos, M, Kanesa-Thasan, N, Bourguignon, P, Collard, A, Buchbinder, S, Tomaras, GD, McElrath, J, Gray, G, Kublin, JG, Corey, L, and Gilbert, PB. "Selection of HIV vaccine candidates for concurrent testing in an efficacy trial." Current Opinion in Virology 17 (April 2016): 57-65. (Review) Full Text
  - Mkhize, NN, Durgiah, R, Ashley, V, Archary, D, Garrett, NJ, Karim, QA, Karim, SSA, Moore, PL, Yates, N, Passmore, J-AS, Tomaras, GD, and Morris, L. "Broadly neutralizing antibody specificities detected in the genital tract of HIV-1 infected women." AIDS (London, England) 30, no. 7 (April 2016): 1005-1014. Full Text
  - Zhang, R, Verkoczy, L, Wiehe, K, Munir Alam, S, Nicely, NI, Santra, S, Bradley, T, Pemble, CW, Zhang, J, Gao, F, Montefiori, DC, Bouton-Verville, H, Kelsoe, G, Larimore, K, Greenberg, PD, Parks, R, Foulger, A, Peel, JN, Luo, K, Lu, X, Trama, AM, Vandergrift, N, Tomaras, GD, Kepler, TB, Moody, MA, Liao, H-X, and Haynes, BF. "Initiation of immune tolerance-controlled HIV gp41 neutralizing B cell lineages." Science Translational Medicine 8, no. 336 (April 2016): 336ra62-null. Full Text
  - Havenar-Daughton, C, Lindqvist, M, Heit, A, Wu, JE, Reiss, SM, Kendric, K, Bélanger, S, Kasturi, SP, Landais, E, Akondy, RS, McGuire, HM, Bothwell, M, Vagefi, PA, Scully, E, IAVI Protocol C Principal Investigators, , Tomaras, GD, Davis, MM, Poignard, P, Ahmed, R, Walker, BD, Pulendran, B, McElrath, MJ, Kaufmann, DE, and Crotty, S. "CXCL13 is a plasma biomarker of germinal center activity." Proceedings of the National Academy of Sciences of the United States of America 113, no. 10 (March 2016): 2702-2707. Full Text
  - Walsh, SR, Moodie, Z, Fiore-Gartland, AJ, Morgan, C, Wilck, MB, Hammer, SM, Buchbinder, SP, Kalams, SA, Goepfert, PA, Mulligan, MJ, Keefer, MC, Baden, LR, Swann, EM, Grant, S, Ahmed, H, Li, F, Hertz, T, Self, SG, Friedrich, D, Frahm, N, Liao, H-X, Montefiori, DC, Tomaras, GD, McElrath, MJ, Hural, J, Graham, BS, Jin, X, and HVTN 083 Study Group and the NIAID HVTN, . "Vaccination With Heterologous HIV-1 Envelope Sequences and Heterologous Adenovirus Vectors Increases T-Cell Responses to Conserved Regions: HVTN 083." J Infect Dis 213, no. 4 (February 15, 2016): 541-550. Full Text Link to Item
  - Churchyard, G, Mlisana, K, Karuna, S, Williamson, A-L, Williamson, C, Morris, L, Tomaras, GD, De Rosa, SC, Gilbert, PB, Gu, N, Yu, C, Mkhize, NN, Hermanus, T, Allen, M, Pensiero, M, Barnett, SW, Gray, G, Bekker, L-G, Montefiori, DC, Kublin, J, and Corey, L. "Sequential Immunization with gp140 Boosts Immune Responses Primed by Modified Vaccinia Ankara or DNA in HIV-Uninfected South African Participants." Plos One 11, no. 9 (January 2016): e0161753-null. Full Text
  - Cosgrove, CA, Lacey, CJ, Cope, AV, Bartolf, A, Morris, G, Yan, C, Baden, S, Cole, T, Carter, D, Brodnicki, E, Shen, X, Joseph, S, DeRosa, SC, Peng, L, Yu, X, Ferrari, G, Seaman, M, Montefiori, DC, Frahm, N, Tomaras, GD, Stöhr, W, McCormack, S, and Shattock, RJ. "Comparative Immunogenicity of HIV-1 gp140 Vaccine Delivered by Parenteral, and Mucosal Routes in Female Volunteers; MUCOVAC2, A Randomized Two Centre Study." Plos One 11, no. 5 (January 2016): e0152038-null. Full Text
  - Sajadi, MM, Farshidpour, M, Brown, EP, Ouyang, X, Seaman, MS, Pazgier, M, Ackerman, ME, Robinson, H, Tomaras, G, Parsons, MS, Charurat, M, DeVico, AL, Redfield, RR, and Lewis, GK. "λ Light Chain Bias Associated With Enhanced Binding and Function of Anti-HIV Env Glycoprotein Antibodies." The Journal of infectious diseases 213, no. 1 (January 2016): 156-164. Full Text
  - Zurawski, G, Zurawski, S, Flamar, A-L, Richert, L, Wagner, R, Tomaras, GD, Montefiori, DC, Roederer, M, Ferrari, G, Lacabaratz, C, Bonnabau, H, Klucar, P, Wang, Z, Foulds, KE, Kao, S-F, Yates, NL, LaBranche, C, Jacobs, BL, Kibler, K, Asbach, B, Kliche, A, Salazar, A, Reed, S, Self, S, Gottardo, R, Galmin, L, Weiss, D, Cristillo, A, Thiebaut, R, Pantaleo, G, and Levy, Y. "Targeting HIV-1 Env gp140 to LOX-1 Elicits Immune Responses in Rhesus Macaques." Plos One 11, no. 4 (January 2016): e0153484-null. Full Text
  - Cubas, R, van Grevenynghe, J, Wills, S, Kardava, L, Santich, BH, Buckner, CM, Muir, R, Tardif, V, Nichols, C, Procopio, F, He, Z, Metcalf, T, Ghneim, K, Locci, M, Ancuta, P, Routy, J-P, Trautmann, L, Li, Y, McDermott, AB, Koup, RA, Petrovas, C, Migueles, SA, Connors, M, Tomaras, GD, Moir, S, Crotty, S, and Haddad, EK. "Reversible Reprogramming of Circulating Memory T Follicular Helper Cell Function during Chronic HIV Infection." Journal of immunology (Baltimore, Md. : 1950) 195, no. 12 (December 2015): 5625-5636. Full Text
  - Santra, S, Tomaras, GD, Warrier, R, Nicely, NI, Liao, H-X, Pollara, J, Liu, P, Alam, SM, Zhang, R, Cocklin, SL, Shen, X, Duffy, R, Xia, S-M, Schutte, RJ, Pemble Iv, CW, Dennison, SM, Li, H, Chao, A, Vidnovic, K, Evans, A, Klein, K, Kumar, A, Robinson, J, Landucci, G, Forthal, DN, Montefiori, DC, Kaewkungwal, J, Nitayaphan, S, Pitisuttithum, P, Rerks-Ngarm, S, Robb, ML, Michael, NL, Kim, JH, Soderberg, KA, Giorgi, EE, Blair, L, Korber, BT, Moog, C, Shattock, RJ, Letvin, NL, Schmitz, JE, Moody, MA, Gao, F, Ferrari, G, Shaw, GM, and Haynes, BF. "Human Non-neutralizing HIV-1 Envelope Monoclonal Antibodies Limit the Number of Founder Viruses during SHIV Mucosal Infection in Rhesus Macaques." Plos Pathogens 11, no. 8 (August 3, 2015): e1005042-null. Full Text Open Access Copy
  - García-Arriaza, J, Perdiguero, B, Heeney, J, Seaman, M, Montefiori, DC, Labranche, C, Yates, NL, Shen, X, Tomaras, GD, Ferrari, G, Foulds, KE, McDermott, A, Kao, S-F, Roederer, M, Hawkins, N, Self, S, Yao, J, Farrell, P, Phogat, S, Tartaglia, J, Barnett, SW, Burke, B, Cristillo, A, Weiss, D, Lee, C, Kibler, K, Jacobs, B, Asbach, B, Wagner, R, Ding, S, Pantaleo, G, and Esteban, M. "Head-to-Head Comparison of Poxvirus NYVAC and ALVAC Vectors Expressing Identical HIV-1 Clade C Immunogens in Prime-Boost Combination with Env Protein in Nonhuman Primates." Journal of Virology 89, no. 16 (August 2015): 8525-8539. Full Text
  - Shen, X, Duffy, R, Howington, R, Cope, A, Sadagopal, S, Park, H, Pal, R, Kwa, S, Ding, S, Yang, OO, Fouda, GG, Le Grand, R, Bolton, D, Esteban, M, Phogat, S, Roederer, M, Amara, RR, Picker, LJ, Seder, RA, McElrath, MJ, Barnett, S, Permar, SR, Shattock, R, DeVico, AL, Felber, BK, Pavlakis, GN, Pantaleo, G, Korber, BT, Montefiori, DC, and Tomaras, GD. "Vaccine-Induced Linear Epitope-Specific Antibodies to Simian Immunodeficiency Virus SIVmac239 Envelope Are Distinct from Those Induced to the Human Immunodeficiency Virus Type 1 Envelope in Nonhuman Primates." Journal of Virology 89, no. 16 (August 2015): 8643-8650. Full Text
  - Williams, WB, Liao, H-X, Moody, MA, Kepler, TB, Alam, SM, Gao, F, Wiehe, K, Trama, AM, Jones, K, Zhang, R, Song, H, Marshall, DJ, Whitesides, JF, Sawatzki, K, Hua, A, Liu, P, Tay, MZ, Seaton, KE, Shen, X, Foulger, A, Lloyd, KE, Parks, R, Pollara, J, Ferrari, G, Yu, J-S, Vandergrift, N, Montefiori, DC, Sobieszczyk, ME, Hammer, S, Karuna, S, Gilbert, P, Grove, D, Grunenberg, N, McElrath, MJ, Mascola, JR, Koup, RA, Corey, L, Nabel, GJ, Morgan, C, Churchyard, G, Maenza, J, Keefer, M, Graham, BS, Baden, LR, Tomaras, GD, and Haynes, BF. "HIV-1 VACCINES. Diversion of HIV-1 vaccine-induced immunity by gp41-microbiota cross-reactive antibodies." Science (New York, N.Y.) 349, no. 6249 (August 2015): aab1253-null. Full Text
  - Prentice, HA, Tomaras, GD, Geraghty, DE, Apps, R, Fong, Y, Ehrenberg, PK, Rolland, M, Kijak, GH, Krebs, SJ, Nelson, W, DeCamp, A, Shen, X, Yates, NL, Zolla-Pazner, S, Nitayaphan, S, Rerks-Ngarm, S, Kaewkungwal, J, Pitisuttithum, P, Ferrari, G, McElrath, MJ, Montefiori, DC, Bailer, RT, Koup, RA, O'Connell, RJ, Robb, ML, Michael, NL, Gilbert, PB, Kim, JH, and Thomas, R. "HLA class II genes modulate vaccine-induced antibody responses to affect HIV-1 acquisition." Science Translational Medicine 7, no. 296 (July 2015): 296ra112-null. Full Text
  - Kwa, S, Sadagopal, S, Shen, X, Hong, JJ, Gangadhara, S, Basu, R, Victor, B, Iyer, SS, LaBranche, CC, Montefiori, DC, Tomaras, GD, Villinger, F, Moss, B, Kozlowski, PA, and Amara, RR. "CD40L-adjuvanted DNA/modified vaccinia virus Ankara simian immunodeficiency virus (SIV) vaccine enhances protection against neutralization-resistant mucosal SIV infection." Journal of Virology 89, no. 8 (April 2015): 4690-4695. Full Text
  - Bogers, WM, Oostermeijer, H, Mooij, P, Koopman, G, Verschoor, EJ, Davis, D, Ulmer, JB, Brito, LA, Cu, Y, Banerjee, K, Otten, GR, Burke, B, Dey, A, Heeney, JL, Shen, X, Tomaras, GD, Labranche, C, Montefiori, DC, Liao, H-X, Haynes, B, Geall, AJ, and Barnett, SW. "Potent immune responses in rhesus macaques induced by nonviral delivery of a self-amplifying RNA vaccine expressing HIV type 1 envelope with a cationic nanoemulsion." The Journal of Infectious Diseases 211, no. 6 (March 2015): 947-955. Full Text
  - Fouda, GG, Cunningham, CK, McFarland, EJ, Borkowsky, W, Muresan, P, Pollara, J, Song, LY, Liebl, BE, Whitaker, K, Shen, X, Vandergrift, NA, Overman, RG, Yates, NL, Moody, MA, Fry, C, Kim, JH, Michael, NL, Robb, M, Pitisuttithum, P, Kaewkungwal, J, Nitayaphan, S, Rerks-Ngarm, S, Liao, H-X, Haynes, BF, Montefiori, DC, Ferrari, G, Tomaras, GD, and Permar, SR. "Infant HIV type 1 gp120 vaccination elicits robust and durable anti-V1V2 immunoglobulin G responses and only rare envelope-specific immunoglobulin A responses." The Journal of Infectious Diseases 211, no. 4 (February 2015): 508-517. Full Text
  - Bart, P-A, Huang, Y, Karuna, ST, Chappuis, S, Gaillard, J, Kochar, N, Shen, X, Allen, MA, Ding, S, Hural, J, Liao, H-X, Haynes, BF, Graham, BS, Gilbert, PB, McElrath, MJ, Montefiori, DC, Tomaras, GD, Pantaleo, G, and Frahm, N. "HIV-specific humoral responses benefit from stronger prime in phase Ib clinical trial." The Journal of Clinical Investigation 124, no. 11 (November 2014): 4843-4856. Full Text
  - Stieh, DJ, King, DF, Klein, K, Liu, P, Shen, X, Hwang, KK, Ferrari, G, Montefiori, DC, Haynes, B, Pitisuttithum, P, Kaewkungwal, J, Nitayaphan, S, Rerks-Ngarm, S, Michael, NL, Robb, ML, Kim, JH, Denny, TN, Tomaras, GD, and Shattock, RJ. "Aggregate complexes of HIV-1 induced by multimeric antibodies." Retrovirology 11 (October 2, 2014): 78-null. Full Text Open Access Copy
  - Liu, P, Williams, LD, Shen, X, Bonsignori, M, Vandergrift, NA, Overman, RG, Moody, MA, Liao, H-X, Stieh, DJ, McCotter, KL, French, AL, Hope, TJ, Shattock, R, Haynes, BF, and Tomaras, GD. "Capacity for infectious HIV-1 virion capture differs by envelope antibody specificity." Journal of Virology 88, no. 9 (May 2014): 5165-5170. Full Text
  - Nair, SK, Tomaras, GD, Sales, AP, Boczkowski, D, Chan, C, Plonk, K, Cai, Y, Dannull, J, Kepler, TB, Pruitt, SK, and Weinhold, KJ. "High-throughput identification and dendritic cell-based functional validation of MHC class I-restricted Mycobacterium tuberculosis epitopes." Scientific reports 4 (April 23, 2014): 4632-. Full Text
  - Hwang, K-K, Trama, AM, Kozink, DM, Chen, X, Wiehe, K, Cooper, AJ, Xia, S-M, Wang, M, Marshall, DJ, Whitesides, J, Alam, M, Tomaras, GD, Allen, SL, Rai, KR, McKeating, J, Catera, R, Yan, X-J, Chu, CC, Kelsoe, G, Liao, H-X, Chiorazzi, N, and Haynes, BF. "IGHV1-69 B cell chronic lymphocytic leukemia antibodies cross-react with HIV-1 and hepatitis C virus antigens as well as intestinal commensal bacteria." Plos One 9, no. 3 (January 2014): e90725-null. Full Text Open Access Copy
  - Jalah, R, Kulkarni, V, Patel, V, Rosati, M, Alicea, C, Bear, J, Yu, L, Guan, Y, Shen, X, Tomaras, GD, LaBranche, C, Montefiori, DC, Prattipati, R, Pinter, A, Bess, J, Lifson, JD, Reed, SG, Sardesai, NY, Venzon, DJ, Valentin, A, Pavlakis, GN, and Felber, BK. "DNA and protein co-immunization improves the magnitude and longevity of humoral immune responses in macaques." Plos One 9, no. 3 (January 2014): e91550-null. Full Text
  - Roederer, M, Keele, BF, Schmidt, SD, Mason, RD, Welles, HC, Fischer, W, Labranche, C, Foulds, KE, Louder, MK, Yang, ZY, Todd, JPM, Buzby, AP, Mach, LV, Shen, L, Seaton, KE, Ward, BM, Bailer, RT, Gottardo, R, Gu, W, Ferrari, G, Alam, SM, Denny, TN, Montefiori, DC, Tomaras, GD, Korber, BT, Nason, MC, Seder, RA, Koup, RA, Letvin, NL, Rao, SS, Nabel, GJ, and Mascola, JR. "Immunological and virological mechanisms of vaccine-mediated protection against SIV and HIV." Nature 505, no. 7484 (January 1, 2014): 502-508. Full Text
  - Seaton, KE, Ballweber, L, Lan, A, Donathan, M, Hughes, S, Vojtech, L, Moody, MA, Liao, H-X, Haynes, BF, Galloway, CG, Richardson, BA, Karim, SA, Dezzutti, CS, McElrath, MJ, Tomaras, GD, and Hladik, F. "HIV-1 specific IgA detected in vaginal secretions of HIV uninfected women participating in a microbicide trial in Southern Africa are primarily directed toward gp120 and gp140 specificities." PloS one 9, no. 7 (January 2014): e101863-. Full Text
  - Kulkarni, V, Rosati, M, Valentin, A, Jalah, R, Alicea, C, Yu, L, Guan, Y, Shen, X, Tomaras, GD, LaBranche, C, Montefiori, DC, Irene, C, Prattipati, R, Pinter, A, Sullivan, SM, Pavlakis, GN, and Felber, BK. "Vaccination with Vaxfectin(®) adjuvanted SIV DNA induces long-lasting humoral immune responses able to reduce SIVmac251 Viremia." Human Vaccines & Immunotherapeutics 9, no. 10 (October 2013): 2069-2080. Full Text
  - Imholte, GC, Sauteraud, R, Korber, B, Bailer, RT, Turk, ET, Shen, X, Tomaras, GD, Mascola, JR, Koup, RA, Montefiori, DC, and Gottardo, R. "A computational framework for the analysis of peptide microarray antibody binding data with application to HIV vaccine profiling." Journal of Immunological Methods 395, no. 1-2 (September 2013): 1-13. Full Text
  - Schiffner, T, Kong, L, Duncan, CJA, Back, JW, Benschop, JJ, Shen, X, Huang, PS, Stewart-Jones, GB, DeStefano, J, Seaman, MS, Tomaras, GD, Montefiori, DC, Schief, WR, and Sattentau, QJ. "Immune focusing and enhanced neutralization induced by HIV-1 gp140 chemical cross-linking." Journal of Virology 87, no. 18 (September 2013): 10163-10172. Full Text
  - Liu, P, Yates, NL, Shen, X, Bonsignori, M, Moody, MA, Liao, H-X, Fong, Y, Alam, SM, Overman, RG, Denny, T, Ferrari, G, Ochsenbauer, C, Kappes, JC, Polonis, VR, Pitisuttithum, P, Kaewkungwal, J, Nitayaphan, S, Rerks-Ngarm, S, Montefiori, DC, Gilbert, P, Michael, NL, Kim, JH, Haynes, BF, and Tomaras, GD. "Infectious virion capture by HIV-1 gp120-specific IgG from RV144 vaccinees." J Virol 87, no. 14 (July 2013): 7828-7836. Full Text Open Access Copy Link to Item
  - Tomaras, GD, Ferrari, G, Shen, X, Alam, SM, Liao, H-X, Pollara, J, Bonsignori, M, Moody, MA, Fong, Y, Chen, X, Poling, B, Nicholson, CO, Zhang, R, Lu, X, Parks, R, Kaewkungwal, J, Nitayaphan, S, Pitisuttithum, P, Rerks-Ngarm, S, Gilbert, PB, Kim, JH, Michael, NL, Montefiori, DC, and Haynes, BF. "Vaccine-induced plasma IgA specific for the C1 region of the HIV-1 envelope blocks binding and effector function of IgG." Proc Natl Acad Sci U S A 110, no. 22 (May 28, 2013): 9019-9024. Full Text Link to Item
  - Patel, V, Jalah, R, Kulkarni, V, Valentin, A, Rosati, M, Alicea, C, von Gegerfelt, A, Huang, W, Guan, Y, Keele, BF, Bess, JW, Piatak, M, Lifson, JD, Williams, WT, Shen, X, Tomaras, GD, Amara, RR, Robinson, HL, Johnson, W, Broderick, KE, Sardesai, NY, Venzon, DJ, Hirsch, VM, Felber, BK, and Pavlakis, GN. "DNA and virus particle vaccination protects against acquisition and confers control of viremia upon heterologous simian immunodeficiency virus challenge." Proceedings of the National Academy of Sciences of the United States of America 110, no. 8 (February 2013): 2975-2980. Full Text
  - Zolla-Pazner, S, deCamp, AC, Cardozo, T, Karasavvas, N, Gottardo, R, Williams, C, Morris, DE, Tomaras, G, Rao, M, Billings, E, Berman, P, Shen, X, Andrews, C, O'Connell, RJ, Ngauy, V, Nitayaphan, S, de Souza, M, Korber, B, Koup, R, Bailer, RT, Mascola, JR, Pinter, A, Montefiori, D, Haynes, BF, Robb, ML, Rerks-Ngarm, S, Michael, NL, Gilbert, PB, and Kim, JH. "Analysis of V2 Antibody Responses Induced in Vaccinees in the ALVAC/AIDSVAX HIV-1 Vaccine Efficacy Trial." Plos One 8, no. 1 (January 17, 2013). Full Text Link to Item
  - Gottardo, R, Bailer, RT, Korber, BT, Gnanakaran, S, Phillips, J, Shen, X, Tomaras, GD, Turk, E, Imholte, G, Eckler, L, Wenschuh, H, Zerweck, J, Greene, K, Gao, H, Berman, PW, Francis, D, Sinangil, F, Lee, C, Nitayaphan, S, Rerks-Ngarm, S, Kaewkungwal, J, Pitisuttithum, P, Tartaglia, J, Robb, ML, Michael, NL, Kim, JH, Zolla-Pazner, S, Haynes, BF, Mascola, JR, Self, S, Gilbert, P, and Montefiori, DC. "Plasma IgG to linear epitopes in the V2 and V3 regions of HIV-1 gp120 correlate with a reduced risk of infection in the RV144 vaccine efficacy trial.(Published online)" Plos One 8, no. 9 (2013): e75665-null. Full Text Link to Item
  - Imholte, GC, Sauteraud, R, Korber, B, Bailer, RT, Turk, ET, Shen, X, Tomaras, GD, Mascola, JR, Koup, RA, Montefiori, DC, and Gottardo, R. "A computational framework for the analysis of peptide microarray antibody binding data with application to HIV vaccine profiling." Journal of Immunological Methods 395, no. 1-2 (2013): 1-13. Full Text
  - Karasavvas, N, Billings, E, Rao, M, Williams, C, Zolla-Pazner, S, Bailer, RT, Koup, RA, Madnote, S, Arworn, D, Shen, X, Tomaras, GD, Currier, JR, Jiang, M, Magaret, C, Andrews, C, Gottardo, R, Gilbert, P, Cardozo, TJ, Rerks-Ngarm, S, Nitayaphan, S, Pitisuttithum, P, Kaewkungwal, J, Paris, R, Greene, K, Gao, H, Gurunathan, S, Tartaglia, J, Sinangil, F, Korber, BT, Montefiori, DC, Mascola, JR, Robb, ML, Haynes, BF, Ngauy, V, Michael, NL, Kim, JH, de Souza, MS, and MOPH TAVEG Collaboration, . "The Thai Phase III HIV Type 1 Vaccine trial (RV144) regimen induces antibodies that target conserved regions within the V2 loop of gp120." Aids Res Hum Retroviruses 28, no. 11 (November 2012): 1444-1457. Full Text Link to Item
  - Haynes, BF, Gilbert, PB, McElrath, MJ, Zolla-Pazner, S, Tomaras, GD, Alam, SM, Evans, DT, Montefiori, DC, Karnasuta, C, Sutthent, R, Liao, H-X, DeVico, AL, Lewis, GK, Williams, C, Pinter, A, Fong, Y, Janes, H, DeCamp, A, Huang, Y, Rao, M, Billings, E, Karasavvas, N, Robb, ML, Ngauy, V, de Souza, MS, Paris, R, Ferrari, G, Bailer, RT, Soderberg, KA, Andrews, C, Berman, PW, Frahm, N, De Rosa, SC, Alpert, MD, Yates, NL, Shen, X, Koup, RA, Pitisuttithum, P, Kaewkungwal, J, Nitayaphan, S, Rerks-Ngarm, S, Michael, NL, and Kim, JH. "Immune-correlates analysis of an HIV-1 vaccine efficacy trial." N Engl J Med 366, no. 14 (April 5, 2012): 1275-1286. Full Text Link to Item
  - Tomaras, GD, Binley, JM, Gray, ES, Crooks, ET, Osawa, K, Moore, PL, Tumba, N, Tong, T, Shen, X, Yates, NL, Decker, J, Wibmer, CK, Gao, F, Alam, SM, Easterbrook, P, Abdool Karim, S, Kamanga, G, Crump, JA, Cohen, M, Shaw, GM, Mascola, JR, Haynes, BF, Montefiori, DC, and Morris, L. "Polyclonal B cell responses to conserved neutralization epitopes in a subset of HIV-1-infected individuals." Journal of Virology 85, no. 21 (November 2011): 11502-11519. Full Text
  - Zhu, Z, Qin, HR, Chen, W, Zhao, Q, Shen, X, Schutte, R, Wang, Y, Ofek, G, Streaker, E, Prabakaran, P, Fouda, GG, Liao, H-X, Owens, J, Louder, M, Yang, Y, Klaric, K-A, Moody, MA, Mascola, JR, Scott, JK, Kwong, PD, Montefiori, D, Haynes, BF, Tomaras, GD, and Dimitrov, DS. "Cross-reactive HIV-1-neutralizing human monoclonal antibodies identified from a patient with 2F5-like antibodies." J Virol 85, no. 21 (November 2011): 11401-11408. Full Text Link to Item
  - Fouda, GG, Yates, NL, Pollara, J, Shen, X, Overman, GR, Mahlokozera, T, Wilks, AB, Kang, HH, Salazar-Gonzalez, JF, Salazar, MG, Kalilani, L, Meshnick, SR, Hahn, BH, Shaw, GM, Lovingood, RV, Denny, TN, Haynes, B, Letvin, NL, Ferrari, G, Montefiori, DC, Tomaras, GD, Permar, SR, and Center for HIV/AIDS Vaccine Immunology, . "HIV-specific functional antibody responses in breast milk mirror those in plasma and are primarily mediated by IgG antibodies." Journal of Virology 85, no. 18 (September 2011): 9555-9567. Full Text Open Access Copy
  - Spearman, P, Lally, MA, Elizaga, M, Montefiori, D, Tomaras, GD, McElrath, MJ, Hural, J, De Rosa, SC, Sato, A, Huang, Y, Frey, SE, Sato, P, Donnelly, J, Barnett, S, Corey, LJ, and HIV Vaccine Trials Network of NIAID, . "A trimeric, V2-deleted HIV-1 envelope glycoprotein vaccine elicits potent neutralizing antibodies but limited breadth of neutralization in human volunteers." The Journal of Infectious Diseases 203, no. 8 (April 2011): 1165-1173. Full Text
  - Shen, X, and Tomaras, GD. "Alterations of the B-cell response by HIV-1 replication." Current Hiv/Aids Reports 8, no. 1 (March 2011): 23-30. Full Text
  - Keefer, MC, Frey, SE, Elizaga, M, Metch, B, De Rosa, SC, Barroso, PF, Tomaras, G, Cardinali, M, Goepfert, P, Kalichman, A, Philippon, V, McElrath, MJ, Jin, X, Ferrari, G, Defawe, OD, Mazzara, GP, Montefiori, D, Pensiero, M, Panicali, DL, Corey, L, and NIAID HIV Vaccine Trials Network, . "A phase I trial of preventive HIV vaccination with heterologous poxviral-vectors containing matching HIV-1 inserts in healthy HIV-uninfected subjects." Vaccine 29, no. 10 (February 2011): 1948-1958. Full Text
  - Churchyard, GJ, Morgan, C, Adams, E, Hural, J, Graham, BS, Moodie, Z, Grove, D, Gray, G, Bekker, L-G, McElrath, MJ, Tomaras, GD, Goepfert, P, Kalams, S, Baden, LR, Lally, M, Dolin, R, Blattner, W, Kalichman, A, Figueroa, JP, Pape, J, Schechter, M, Defawe, O, De Rosa, SC, Montefiori, DC, Nabel, GJ, Corey, L, Keefer, MC, and NIAID HIV Vaccine Trials Network, . "A phase IIA randomized clinical trial of a multiclade HIV-1 DNA prime followed by a multiclade rAd5 HIV-1 vaccine boost in healthy adults (HVTN204)." Plos One 6, no. 8 (January 2011): e21225-null. Full Text
  - Dennison, SM, Sutherland, LL, Jaeger, FH, Anasti, KM, Parks, R, Stewart, S, Bowman, C, Xia, S-M, Zhang, R, Shen, X, Scearce, RM, Ofek, G, Yang, Y, Kwong, PD, Santra, S, Liao, H-X, Tomaras, G, Letvin, NL, Chen, B, Alam, SM, and Haynes, BF. "Induction of antibodies in rhesus macaques that recognize a fusion-intermediate conformation of HIV-1 gp41." Plos One 6, no. 11 (2011): e27824-null. Full Text Link to Item
  - Moody, MA, Zhang, R, Walter, EB, Woods, CW, Ginsburg, GS, McClain, MT, Denny, TN, Chen, X, Munshaw, S, Marshall, DJ, Whitesides, JF, Drinker, MS, Amos, JD, Gurley, TC, Eudailey, JA, Foulger, A, DeRosa, KR, Parks, R, Meyerhoff, RR, Yu, J-S, Kozink, DM, Barefoot, BE, Ramsburg, EA, Khurana, S, Golding, H, Vandergrift, NA, Alam, SM, Tomaras, GD, Kepler, TB, Kelsoe, G, Liao, H-X, and Haynes, BF. "H3N2 influenza infection elicits more cross-reactive and less clonally expanded anti-hemagglutinin antibodies than influenza vaccination." Plos One 6, no. 10 (January 2011): e25797-null. Full Text
  - Morris, L, Chen, X, Alam, M, Tomaras, G, Zhang, R, Marshall, DJ, Chen, B, Parks, R, Foulger, A, Jaeger, F, Donathan, M, Bilska, M, Gray, ES, Abdool Karim, SS, Kepler, TB, Whitesides, J, Montefiori, D, Moody, MA, Liao, H-X, and Haynes, BF. "Isolation of a human anti-HIV gp41 membrane proximal region neutralizing antibody by antigen-specific single B cell sorting." Plos One 6, no. 9 (2011): e23532-null. Full Text Link to Item
  - Peiperl, L, Morgan, C, Moodie, Z, Li, H, Russell, N, Graham, BS, Tomaras, GD, De Rosa, SC, McElrath, MJ, and NIAID HIV Vaccine Trials Network, . "Safety and immunogenicity of a replication-defective adenovirus type 5 HIV vaccine in Ad5-seronegative persons: a randomized clinical trial (HVTN 054)." PloS one 5, no. 10 (October 27, 2010): e13579-. Full Text Open Access Copy
  - Liu, J, Keele, BF, Li, H, Keating, S, Norris, PJ, Carville, A, Mansfield, KG, Tomaras, GD, Haynes, BF, Kolodkin-Gal, D, Letvin, NL, Hahn, BH, Shaw, GM, and Barouch, DH. "Low-dose mucosal simian immunodeficiency virus infection restricts early replication kinetics and transmitted virus variants in rhesus monkeys." Journal of Virology 84, no. 19 (October 2010): 10406-10412. Full Text
  - Haynes, BF, Liao, H-X, and Tomaras, GD. "Is developing an HIV-1 vaccine possible?." Current Opinion in Hiv and Aids 5, no. 5 (September 2010): 362-367. (Review) Full Text
  - Saunders, KO, Freel, SA, Overman, RG, Cunningham, CK, and Tomaras, GD. "Epigenetic regulation of CD8(+) T-lymphocyte mediated suppression of HIV-1 replication." Virology 405, no. 1 (September 2010): 234-242. Full Text
  - Tomaras, GD, and Haynes, BF. "Strategies for eliciting HIV-1 inhibitory antibodies." Current Opinion in Hiv and Aids 5, no. 5 (September 2010): 421-427. (Review) Full Text
  - Freel, SA, Lamoreaux, L, Chattopadhyay, PK, Saunders, K, Zarkowsky, D, Overman, RG, Ochsenbauer, C, Edmonds, TG, Kappes, JC, Cunningham, CK, Denny, TN, Weinhold, KJ, Ferrari, G, Haynes, BF, Koup, RA, Graham, BS, Roederer, M, and Tomaras, GD. "Phenotypic and functional profile of HIV-inhibitory CD8 T cells elicited by natural infection and heterologous prime/boost vaccination." Journal of Virology 84, no. 10 (May 2010): 4998-5006. Full Text
  - Moody, MA, Liao, H-X, Alam, SM, Scearce, RM, Plonk, MK, Kozink, DM, Drinker, MS, Zhang, R, Xia, S-M, Sutherland, LL, Tomaras, GD, Giles, IP, Kappes, JC, Ochsenbauer-Jambor, C, Edmonds, TG, Soares, M, Barbero, G, Forthal, DN, Landucci, G, Chang, C, King, SW, Kavlie, A, Denny, TN, Hwang, K-K, Chen, PP, Thorpe, PE, Montefiori, DC, and Haynes, BF. "Anti-phospholipid human monoclonal antibodies inhibit CCR5-tropic HIV-1 and induce beta-chemokines." J Exp Med 207, no. 4 (April 12, 2010): 763-776. Full Text Open Access Copy Link to Item
  - Shen, X, Dennison, SM, Liu, P, Gao, F, Jaeger, F, Montefiori, DC, Verkoczy, L, Haynes, BF, Alam, SM, and Tomaras, GD. "Prolonged exposure of the HIV-1 gp41 membrane proximal region with L669S substitution." Proceedings of the National Academy of Sciences of the United States of America 107, no. 13 (March 15, 2010): 5972-5977. Full Text
  - Nandi, A, Lavine, CL, Wang, P, Lipchina, I, Goepfert, PA, Shaw, GM, Tomaras, GD, Montefiori, DC, Haynes, BF, Easterbrook, P, Robinson, JE, Sodroski, JG, Yang, X, and NIAID Center for HIV/AIDS Vaccine Immunology, . "Epitopes for broad and potent neutralizing antibody responses during chronic infection with human immunodeficiency virus type 1." Virology 396, no. 2 (January 20, 2010): 339-348. Full Text Link to Item
  - McMichael, AJ, Borrow, P, Tomaras, GD, Goonetilleke, N, and Haynes, BF. "The immune response during acute HIV-1 infection: clues for vaccine development." Nature Reviews. Immunology 10, no. 1 (January 2010): 11-23. (Review) Full Text
  - Gao, F, Scearce, RM, Alam, SM, Hora, B, Xia, S, Hohm, JE, Parks, RJ, Ogburn, DF, Tomaras, GD, Park, E, Lomas, WE, Maino, VC, Fiscus, SA, Cohen, MS, Moody, MA, Hahn, BH, Korber, BT, Liao, H-X, and Haynes, BF. "Cross-reactive monoclonal antibodies to multiple HIV-1 subtype and SIVcpz envelope glycoproteins." Virology 394, no. 1 (November 2009): 91-98. Full Text
  - Gray, ES, Taylor, N, Wycuff, D, Moore, PL, Tomaras, GD, Wibmer, CK, Puren, A, DeCamp, A, Gilbert, PB, Wood, B, Montefiori, DC, Binley, JM, Shaw, GM, Haynes, BF, Mascola, JR, and Morris, L. "Antibody specificities associated with neutralization breadth in plasma from human immunodeficiency virus type 1 subtype C-infected blood donors." Journal of Virology 83, no. 17 (September 2009): 8925-8937. Full Text
  - Tomaras, GD, and Haynes, BF. "HIV-1-specific antibody responses during acute and chronic HIV-1 infection." Current Opinion in Hiv and Aids 4, no. 5 (September 2009): 373-379. (Review) Full Text
  - Bonsignori, M, Moody, MA, Parks, RJ, Holl, TM, Kelsoe, G, Hicks, CB, Vandergrift, N, Tomaras, GD, and Haynes, BF. "HIV-1 envelope induces memory B cell responses that correlate with plasma antibody levels after envelope gp120 protein vaccination or HIV-1 infection." J Immunol 183, no. 4 (August 15, 2009): 2708-2717. Full Text Link to Item
  - Levesque, MC, Moody, MA, Hwang, K-K, Marshall, DJ, Whitesides, JF, Amos, JD, Gurley, TC, Allgood, S, Haynes, BB, Vandergrift, NA, Plonk, S, Parker, DC, Cohen, MS, Tomaras, GD, Goepfert, PA, Shaw, GM, Schmitz, JE, Eron, JJ, Shaheen, NJ, Hicks, CB, Liao, H-X, Markowitz, M, Kelsoe, G, Margolis, DM, and Haynes, BF. "Polyclonal B cell differentiation and loss of gastrointestinal tract germinal centers in the earliest stages of HIV-1 infection." PLoS Med 6, no. 7 (July 7, 2009): e1000107-. Full Text Open Access Copy Link to Item
  - Miller, HB, Saunders, KO, Tomaras, GD, and Garcia-Blanco, MA. "Tat-SF1 is not required for Tat transactivation but does regulate the relative levels of unspliced and spliced HIV-1 RNAs." Plos One 4, no. 5 (May 27, 2009): e5710-null. Full Text
  - Lambotte, O, Ferrari, G, Moog, C, Yates, NL, Liao, H-X, Parks, RJ, Hicks, CB, Owzar, K, Tomaras, GD, Montefiori, DC, Haynes, BF, and Delfraissy, J-F. "Heterogeneous neutralizing antibody and antibody-dependent cell cytotoxicity responses in HIV-1 elite controllers." Aids (London, England) 23, no. 8 (May 2009): 897-906. Full Text
  - Shen, X, Parks, RJ, Montefiori, DC, Kirchherr, JL, Keele, BF, Decker, JM, Blattner, WA, Gao, F, Weinhold, KJ, Hicks, CB, Greenberg, ML, Hahn, BH, Shaw, GM, Haynes, BF, and Tomaras, GD. "In vivo gp41 antibodies targeting the 2F5 monoclonal antibody epitope mediate human immunodeficiency virus type 1 neutralization breadth." Journal of Virology 83, no. 8 (April 2009): 3617-3625. Full Text
  - Maksaereekul, S, Dubie, RA, Shen, X, Kieu, H, Dean, GA, and Sparger, EE. "Vaccination with vif-deleted feline immunodeficiency virus provirus, GM-CSF, and TNF-α plasmids preserves global CD4 T lymphocyte function after challenge with FIV." Vaccine 27, no. 28 (2009): 3754-3765. Full Text
  - Shen, X, Leutenegger, CM, Cole, KS, Pedersen, NC, and Sparger, EE. "A feline immunodeficiency virus vif-deletion mutant remains attenuated upon infection of newborn kittens." Journal of General Virology 88, no. 10 (2007): 2793-2799. Full Text
  - Tomaras, GD, Shen, X, and Greenberg, ML. "Antibody responses and virus escape: implications for HIV-1 vaccine and therapeutic design." Future Virology 1, no. 1 (January 2006): 79-88. Full Text
  - Morris, KV, Higgins, J, Shen, X, Stine, JT, and Pedersen, NC. "The effects of HHV-8 vMIP-II on SIVmac251 infection and replication competent and incompetent SIVmac239Delta3 vectors." Virus Research 94, no. 2 (August 2003): 103-112. Full Text
- Other Articles
  - Zhu, Z, Qin, HR, Chen, W, Zhao, Q, Shen, X, Schutte, R, Wang, Y, Ofek, G, Streaker, E, Prabakaran, P, Fouda, GG, Liao, H-X, Owens, J, Louder, M, Yang, Y, Klaric, K-A, Moody, MA, Mascola, JR, Scott, JK, Kwong, PD, Montefiori, D, Haynes, BF, Tomaras, GD, and Dimitrov, DS. "Cross-Reactive HIV-1-Neutralizing Human Monoclonal Antibodies Identified from a Patient with 2F5-Like Antibodies (vol 85, pg 11401, 2011)." JOURNAL OF VIROLOGY 87, no. 24 (December 2013): 13936-13936. Full Text Link to Item
  - Zhu, Z, Qin, HR, Chen, W, Zhao, Q, Shen, X, Schutte, R, Wang, Y, Ofek, G, Streaker, E, Prabakaran, P, Fouda, GG, Liao, HX, Owens, J, Louder, M, Yang, Y, Klaric, KA, Anthony Moody, M, Mascola, JR, Scott, JK, Kwong, PD, Montefiori, D, Haynes, BF, Tomaras, GD, and Dimitrov, DS. "Erratum to Cross-reactive HIV-1-neutralizing human monoclonal antibodies identified from a patient with 2F5-like antibodies [Journal of Virology, 85, 21, (2011) 11401-11408] DOI: 10.1128/JVI.05312-11." Journal of Virology 87, no. 24 (December 1, 2013): 13936-null. Full Text
  - Shen, X, and Tomaras, GD. "Erratum to: Alterations of the B-Cell Response by HIV-1 Replication." Current Hiv/Aids Reports 8, no. 1 (March 2011): 73-73. Full Text

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