Talal Imad Mousallem | Scholars@Duke

Talal Imad Mousallem
Associate Professor of Pediatrics

I am an allergist and immunologist who cares for children. I manage patients with primary immunodeficiency and different allergic diseases. This includes managing patients with recurrent infections, allergic rhinitis, asthma, food allergy, drug allergy, stinging insect hypersensitivity, urticaria/ angioedema, and allergic skin disease. I also see patients with abnormal severe combined immunodeficiency newborn screen results.

Current Research Interests

My area of research interest is immunogenetics. To date, there are more than 350 different primary immunodeficiencies described in the scientific literature. In some cases, the molecular defect remains unknown. The focus of my research work is investigating the genetic cause of primary immunodeficiency diseases using next-generation sequencing technology in patients where the molecular defect (genetic cause) remains unknown.

Current Appointments & Affiliations

Associate Professor of Pediatrics, Pediatrics, Allergy and Immunology, Pediatrics 2021

Contact Information

Dept of Pediatrics, Box 2644, Durham, NC 27710
Dept of Pediatrics, Box 2644, Durham, NC 27710
(919) 684-8111

Background
Education, Training, & Certifications
- Allergy and Immunology Fellowship, Pediatrics, Duke University School of Medicine 2010 - 2013
- Pediatric Internship and Residency, Pediatrics, Duke University School of Medicine 2007 - 2010
- M.D., American University of Beirut (Lebanon) 2003
Previous Appointments & Affiliations
- Associate Professor of Pediatrics, Pediatrics, Allergy and Immunology, Pediatrics 2019 - 2020
- Instructor in the Department of Pediatrics, Pediatrics, Allergy and Immunology, Pediatrics 2019
- Adjunct Assistant Professor in the Department of Pediatrics, Pediatrics, Allergy and Immunology, Pediatrics 2014 - 2019
Academic Positions Outside Duke
- Adjunct Associate Professor of Internal Medicine, Wake Forest School of Medicine. 2018 - 2019
Research
Selected Grants
- Primary Immune Deficiency Treatment Consortium awarded by University of California - San Francisco 2014 - 2023
- Single Arm, Open-Label, Multicenter, Registry Study of Revcovi® (elapegademase-lvlr) Treatment in ADA-SCID Patients Requiring Enzyme Replacement Therapy awarded by Leadiant Biosciences, Inc. 2021 - 2022
- CLN3: Modulation of Apoptosis and Ceramide Levels awarded by National Institutes of Health 2003 - 2008
Fellowships, Supported Research, & Other Grants
- Whole genome sequencing for primary immunodeficiency awarded by 2013 Clinical Immunology Society/ Grifols Senior Fellowship Award 2013
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Leiding, Jennifer W., Tiphanie P. Vogel, Valentine G. J. Santarlas, Rahul Mhaskar, Madison R. Smith, Alexandre Carisey, Alexander Vargas-Hernández, et al. “Monogenic early-onset lymphoproliferation and autoimmunity: Natural history of STAT3 gain-of-function syndrome.” J Allergy Clin Immunol 151, no. 4 (April 2023): 1081–95. https://doi.org/10.1016/j.jaci.2022.09.002.
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  - Anastasio, Albert T., Lindsey G. Johnson, Jay P. Willhite, Talal Mousallem, Edward F. Hendershot, and Selene G. Parekh. “Team Approach: Metal Hypersensitivity in Total Joint Arthroplasty.” Jbjs Rev 11, no. 1 (January 1, 2023). https://doi.org/10.2106/JBJS.RVW.22.00157.
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  - Geier, Christoph B., Maryssa Ellison, Rachel Cruz, Sumit Pawar, Alexander Leiss-Piller, Katarina Zmajkovicova, Shannon M. McNulty, et al. “Disease Progression of WHIM Syndrome in an International Cohort of 66 Pediatric and Adult Patients.” J Clin Immunol 42, no. 8 (November 2022): 1748–65. https://doi.org/10.1007/s10875-022-01312-7.
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  - Nasir, Aman, Jason W. Caldwell, Katharine Batt, and Talal I. Mousallem. “Combined immunodeficiency presenting as autoimmune hemolytic anemia.” Journal of Allergy and Clinical Immunology 139, no. 2 (February 2017): AB22–AB22. https://doi.org/10.1016/j.jaci.2016.12.026.
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  - Sayour, Elias J., Talal Mousallem, David Van Mater, Endi Wang, Paul Martin, Rebecca H. Buckley, and Raymond C. Barfield. “Bone marrow transplantation for CVID-like humoral immune deficiency associated with red cell aplasia.” Pediatr Blood Cancer 63, no. 10 (October 2016): 1856–59. https://doi.org/10.1002/pbc.26092.
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  - Petrovski, Slavé, Roberta E. Parrott, Joseph L. Roberts, Hongxiang Huang, Jialong Yang, Balachandra Gorentla, Talal Mousallem, et al. “Dominant Splice Site Mutations in PIK3R1 Cause Hyper IgM Syndrome, Lymphadenopathy and Short Stature.” J Clin Immunol 36, no. 5 (July 2016): 462–71. https://doi.org/10.1007/s10875-016-0281-6.
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  - Mousallem, Talal, Thomas J. Urban, K Melodi McSweeney, Sarah E. Kleinstein, Mingfu Zhu, Mehdi Adeli, Roberta E. Parrott, et al. “Clinical application of whole-genome sequencing in patients with primary immunodeficiency.” J Allergy Clin Immunol 136, no. 2 (August 2015): 476-9.e6. https://doi.org/10.1016/j.jaci.2015.02.040.
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  - Mousallem, Talal, Jialong Yang, Thomas J. Urban, Hongxia Wang, Mehdi Adeli, Roberta E. Parrott, Joseph L. Roberts, David B. Goldstein, Rebecca H. Buckley, and Xiao-Ping Zhong. “A nonsense mutation in IKBKB causes combined immunodeficiency.” Blood 124, no. 13 (September 25, 2014): 2046–50. https://doi.org/10.1182/blood-2014-04-571265.
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  - Haddad, Saria El, Marwan Khoury, Mohammad Daoud, Rami Kantar, Hayat Harati, Talal Mousallem, Oscar Alzate, Brian Meyer, and Rose-Mary Boustany. “CLN5 and CLN8 protein association with ceramide synthase: biochemical and proteomic approaches.” Electrophoresis 33, no. 24 (December 2012): 3798–3809. https://doi.org/10.1002/elps.201200472.
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  - McWilliams, Laurie M., Talal Mousallem, and A Wesley Burks. “Future therapies for food allergy.” Hum Vaccin Immunother 8, no. 10 (October 2012): 1479–84. https://doi.org/10.4161/hv.20868.
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  - Mousallem, T., and A. W. Burks. “Immunology in the Clinic Review Series; focus on allergies: immunotherapy for food allergy.” Clin Exp Immunol 167, no. 1 (January 2012): 26–31. https://doi.org/10.1111/j.1365-2249.2011.04499.x.
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  - Guo, Rishu, Chi-Keung Wan, Jeffery H. Carpenter, Talal Mousallem, Rose-Mary N. Boustany, Chien-Tsun Kuan, A Wesley Burks, and Xiao-Ping Zhong. “Synergistic control of T cell development and tumor suppression by diacylglycerol kinase alpha and zeta.” Proc Natl Acad Sci U S A 105, no. 33 (August 19, 2008): 11909–14. https://doi.org/10.1073/pnas.0711856105.
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  - Rusyn, Elena, Talal Mousallem, Dixie-Ann Persaud-Sawin, Sara Miller, and Rose-Mary N. Boustany. “CLN3p impacts galactosylceramide transport, raft morphology, and lipid content.” Pediatr Res 63, no. 6 (June 2008): 625–31. https://doi.org/10.1203/PDR.0b013e31816fdc17.
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  - Persaud-Sawin, Dixie-Ann, Talal Mousallem, Christine Wang, Adam Zucker, Eiki Kominami, and Rose-Mary N. Boustany. “Neuronal ceroid lipofuscinosis: a common pathway?” Pediatr Res 61, no. 2 (February 2007): 146–52. https://doi.org/10.1203/pdr.0b013e31802d8a4a.
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  - Kanj, Souha S., Nadine Dandashi, Aimee El-Hed, Hisham Harik, Maria Maalouf, Lina Kozhaya, Talal Mousallem, et al. “Ceramide regulates SR protein phosphorylation during adenoviral infection.” Virology 345, no. 1 (February 2006): 280–89. https://doi.org/10.1016/j.virol.2005.09.060.
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  - Schulz, Angela, Talal Mousallem, Maya Venkataramani, Dixie-Ann Persaud-Sawin, Adam Zucker, Chiara Luberto, Alicja Bielawska, et al. “The CLN9 Protein, a Regulator of Dihydroceramide Synthase.” Journal of Biological Chemistry 281, no. 5 (February 2006): 2784–94. https://doi.org/10.1074/jbc.m509483200.
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- Book Sections
  - Mousallem, Talal. “Oral allergy syndrome.” In Encyclopedia of Medical Immunology, edited by I. Mackay and N. Rose, 534–37. Springer Science and Business Media, 2014.
  - Mousallem, Talal, and rose Boustany. “Sphingolipid disorders and the neuronal ceroid lipofuscinoses.” In Emery and Rimoin’s Principles and Practice of Medical Genetics, edited by D. L. Rimoin, J. M. Connor, R. E. Pyeritz, B. R. Korf, and B. R. editors, 2449–85. Philadelphia Churchill Livingstone Elsevier, 2006.
- Conference Papers
  - Mousallem, Talal, Jialong Yang, Thomas J. Urban, Hongxia Wang, Roberta E. Parrott, Joseph L. Roberts, Rebecca H. Buckley, Xiaoping Zhong, and David B. Goldstein. “Whole-Exome Sequencing Reveals IKBKB As a Cause of Combined Immunodeficiency.” In Journal of Allergy and Clinical Immunology, 133:AB399–AB399. Elsevier BV, 2014. https://doi.org/10.1016/j.jaci.2013.12.1053.
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  - Mousallem, Talal, Thomas J. Urban, Joseph L. Roberts, Roberta E. Parrott, David B. Goldstein, and Rebecca H. Buckley. “Next Generation Sequencing May Be More Efficient and Economical Than Targeted Gene Testing in Patients with Primary Immune Deficiency (PID).” In Journal of Allergy and Clinical Immunology, 131:AB52–AB52. Elsevier BV, 2013. https://doi.org/10.1016/j.jaci.2012.12.870.
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Scholarly, Clinical, & Service Activities
Academic & Administrative Activities
- Associate Program Director- Allergy and Immunology Fellowship.

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Education, Training, & Certifications

Previous Appointments & Affiliations

Academic Positions Outside Duke

Selected Grants

Fellowships, Supported Research, & Other Grants

Selected Publications

Academic Articles

Book Sections

Conference Papers

Academic & Administrative Activities