Taylor Hinnant

Journal Article PLoS Genet · March 2024 Tissues are subject to multiple mechanical inputs at the cellular level that influence their overall shape and function. In the small intestine, actomyosin contractility can be induced by many physiological and pathological inputs. However, we have little ... Full text Link to item Cite

Compartment specific responses to contractility in the small intestinal epithelium.

Journal Article bioRxiv · August 7, 2023 Tissues are subject to multiple mechanical inputs at the cellular level that influence their overall shape and function. In the small intestine, actomyosin contractility can be induced by many physiological and pathological inputs. However, we have little ... Full text Link to item Cite

β-importin Tnpo-SR promotes germline stem cell maintenance and oocyte differentiation in female Drosophila.

Journal Article Developmental biology · February 2023 Germ cell development requires interplay between factors that balance cell fate and division. Early in their development, germ cells in many organisms divide mitotically with incomplete cytokinesis. Key regulatory events then lead to the specification of m ... Full text Cite

Hair follicle stem cells feel the pressure.

Journal Article Cell Stem Cell · January 6, 2022 The number of hair follicle stem cells decreases during aging and in hair-loss disorders, such as alopecia. In this issue of Cell Stem Cell, Xie et al. (2021) discover that the hair shaft serves as a physical niche component for the preservation of hair fo ... Full text Link to item Cite

Coordinating Proliferation, Polarity, and Cell Fate in the Drosophila Female Germline.

Journal Article Frontiers in cell and developmental biology · January 2020 Gametes are highly specialized cell types produced by a complex differentiation process. Production of viable oocytes requires a series of precise and coordinated molecular events. Early in their development, germ cells are an interconnected group of mitot ... Full text Cite

Novel cis-regulatory regions in ecdysone responsive genes are sufficient to promote gene expression in Drosophila ovarian cells.

Journal Article Gene expression patterns : GEP · December 2019 The insect steroid hormone ecdysone is a key regulator of oogenesis in Drosophila melanogaster and many other species. Despite the diversity of cellular functions of ecdysone in oogenesis, the molecular regulation of most ecdysone-responsive genes in ovari ... Full text Cite

Regulated spindle orientation buffers tissue growth in the epidermis.

Journal Article Elife · October 2, 2019 Tissue homeostasis requires a balance between progenitor cell proliferation and loss. Mechanisms that maintain this robust balance are needed to avoid tissue loss or overgrowth. Here we demonstrate that regulation of spindle orientation/asymmetric cell div ... Full text Open Access Link to item Cite

Temporal remodeling of the cell cycle accompanies differentiation in the Drosophila germline.

Journal Article Developmental biology · September 2017 Development of multicellular organisms relies upon the coordinated regulation of cellular differentiation and proliferation. Growing evidence suggests that some molecular regulatory pathways associated with the cell cycle machinery also dictate cell fate; ... Full text Cite

A Genetic Mosaic Screen Reveals Ecdysone-Responsive Genes Regulating Drosophila Oogenesis.

Journal Article G3 (Bethesda, Md.) · August 2016 Multiple aspects of Drosophila oogenesis, including germline stem cell activity, germ cell differentiation, and follicle survival, are regulated by the steroid hormone ecdysone. While the transcriptional targets of ecdysone signaling during development hav ... Full text Open Access Cite