Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., Temple University 2001
• 

  Duke Appointment History

  • Adjunct Professor in the Department of Biostatistics & Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2013
• Recognition
• 

  Awards & Honors

  • Fellow. American Statistical Association. 2016
• Expertise
• 

  Subject Headings

  • Breast Neoplasms
  • Cohort Studies
  • Colorectal Neoplasms
  • Gastrointestinal Hormones
  • Gastrointestinal Tract
  • Italy
  • Lung Neoplasms
  • Models, Statistical
  • Neoplasm Invasiveness
  • Prognosis
  • Socioeconomic Factors
  • Survival Analysis
  • Thyroid Neoplasms
  • Thyroidectomy
  • Urogenital System
• Research
• 

  Selected Grants

  • Comparison of Operative to Medical Endocrine Therapy (COMET) for Low Risk DCIS  awarded by Alliance for Clinical Trials in Oncology Foundation 2016 - 2021
  • City of Hope / Contract to continue work on 1U01CA189283-01A1  awarded by City of Hope 2015 - 2020
  • Smartphone Enabled Point-of-Care Detection of Serum Markers of Liver Cancer  awarded by National Institutes of Health 2017 - 2019
  • The Mathematics of Breast Cancer Overtreatment: Improving Treatment Choice through Effective Communication of Personalized Cancer Risk  awarded by National Institutes of Health 2016 - 2018
  • Helicobacter pylori blood biomarker for gastric cancer risk in East Asia  awarded by National Institutes of Health 2017 - 2018
  • Innovative Biomarker-Integrated Clinical Trial Design and Analysis  awarded by University of North Carolina - Chapel Hill 2015 - 2018
  • Breast Cancer Research Foundation  awarded by Alliance for Clinical Trials in Oncology Foundation 2015 - 2017
  • Single cell analysis of intratumoral heterogeneity in parathyroid neoplasia  awarded by National Institutes of Health 2015 - 2017
  • National Clinical Trials Network - Network Group Statistics and DMCs  awarded by Mayo Clinic 2014 - 2017
  • Small RNA Sequencing and prospective evaluation of HCC risk in HBV patients  awarded by Thomas Jefferson University 2014 - 2016
  • Combined breast MRI/biomarker strategies to identify aggressive biology  awarded by National Institutes of Health 2015
  • Tension-Stat3-miR-mediated metastasis  awarded by University of California - San Francisco 2015
  • Structural Models of Breast Cancer Outcomes Disparities  awarded by Susan G Komen for the Cure 2014 - 2015
  • Therapy-relevant stratification of breast cancer patients: Integrating pathology and biomarkers analysis  awarded by Thomas Jefferson University 2014 - 2015
  • Occult tumor burden as a marker stratifying therapy to eliminate racial disparities in colon cancer  awarded by Thomas Jefferson University 2014
  • Tumor MicroRNA Signatures as Prognostic Biomarkers of Colorectal Cancer  awarded by Thomas Jefferson University 2014
  • Therapeutic vaccine bridging the gap in racial disparities in colorectal cancer  awarded by Thomas Jefferson University 2014
• Publications & Artistic Works
• 

  Selected Publications

  • Conference Papers

    • Hwang, ES, Locklear, TD, Rushing, CN, Samsa, G, Abernethy, AP, Hyslop, T, and Atisha, DM. "Patient-Reported Outcomes After Choice for Contralateral Prophylactic Mastectomy." May 2016.  Full Text
    • Palumbo, A, Michael, Y, and Hyslop, T. "Abstract 4137: Latent class model characterization of neighborhood SES: Table 1." October 1, 2014.  Full Text

  • Journal Articles

    • Liu, S, Wang, Y, Xue, W, Liu, H, Xu, Y, Shi, Q, Wu, W, Zhu, D, Amos, CI, Fang, S, Lee, JE, Hyslop, T, Li, Y, Han, J, and Wei, Q. "Genetic variants in the genes encoding rho GTPases and related regulators predict cutaneous melanoma-specific survival." International journal of cancer 141, no. 4 (August 2017): 721-730.  Full Text
    • Wang, Y, Freedman, JA, Liu, H, Moorman, PG, Hyslop, T, George, DJ, Lee, NH, Patierno, SR, and Wei, Q. "Associations between RNA splicing regulatory variants of stemness-related genes and racial disparities in susceptibility to prostate cancer." International journal of cancer 141, no. 4 (August 2017): 731-743.  Full Text
    • Anand, S, Thomas, S, Hyslop, T, Adcock, J, Corbet, K, Gasparetto, C, Lopez, R, Long, GD, Morris, AK, Rizzieri, DA, Sullivan, KM, Sung, AD, Sarantopoulos, S, Chao, NJ, and Horwitz, ME. "Transplantation of Ex Vivo Expanded Umbilical Cord Blood (NiCord) Decreases Early Infection and Hospitalization." Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 23, no. 7 (July 2017): 1151-1157.  Full Text
    • Cheng, Q, Li, X, Acharya, CR, Hyslop, T, and Sosa, JA. "A novel integrative risk index of papillary thyroid cancer progression combining genomic alterations and clinical factors." Oncotarget 8, no. 10 (March 2017): 16690-16703.  Full Text
    • Adam, MA, Thomas, S, Hyslop, T, Scheri, RP, Roman, SA, and Sosa, JA. "Exploring the Relationship Between Patient Age and Cancer-Specific Survival in Papillary Thyroid Cancer: Rethinking Current Staging Systems." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 34, no. 36 (December 2016): 4415-4420.  Full Text
    • Hwang, ES, and Hyslop, T. "Reply to J. Heil et al." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 34, no. 34 (December 2016): 4192-.  Full Text
    • Snook, AE, Baybutt, TR, Hyslop, T, and Waldman, SA. "Preclinical Evaluation of a Replication-Deficient Recombinant Adenovirus Serotype 5 Vaccine Expressing Guanylate Cyclase C and the PADRE T-helper Epitope." Human gene therapy methods 27, no. 6 (December 2016): 238-250.  Full Text
    • Greenup, RA, Obeng-Gyasi, S, Thomas, S, Houck, K, Lane, WO, Blitzblau, RC, Hyslop, T, and Hwang, ES. "The Effect of Hospital Volume on Breast Cancer Mortality." Annals of surgery (November 23, 2016).
    • Peck, AR, Girondo, MA, Liu, C, Kovatich, AJ, Hooke, JA, Shriver, CD, Hu, H, Mitchell, EP, Freydin, B, Hyslop, T, Chervoneva, I, and Rui, H. "Validation of tumor protein marker quantification by two independent automated immunofluorescence image analysis platforms." Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 29, no. 10 (October 2016): 1143-1154.  Full Text
    • Robinson, TJ, Thomas, S, Dinan, MA, Roman, S, Sosa, JA, and Hyslop, T. "How Many Lymph Nodes Are Enough? Assessing the Adequacy of Lymph Node Yield for Papillary Thyroid Cancer." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 34, no. 28 (October 2016): 3434-3439.  Full Text
    • Sung, AD, Sung, JAM, Thomas, S, Hyslop, T, Gasparetto, C, Long, G, Rizzieri, D, Sullivan, KM, Corbet, K, Broadwater, G, Chao, NJ, and Horwitz, ME. "Universal Mask Usage for Reduction of Respiratory Viral Infections After Stem Cell Transplant: A Prospective Trial." Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 63, no. 8 (October 2016): 999-1006.  Full Text
    • Lai, Y, Wang, C, Civan, JM, Palazzo, JP, Ye, Z, Hyslop, T, Lin, J, Myers, RE, Li, B, Jiang, B, Sama, A, Xing, J, and Yang, H. "Effects of Cancer Stage and Treatment Differences on Racial Disparities in Survival From Colon Cancer: A United States Population-Based Study." Gastroenterology 150, no. 5 (May 2016): 1135-1146.  Full Text
    • Adam, MA, Thomas, S, Youngwirth, L, Hyslop, T, Reed, SD, Scheri, RP, Roman, SA, and Sosa, JA. "Is There a Minimum Number of Thyroidectomies a Surgeon Should Perform to Optimize Patient Outcomes?." Annals of surgery (March 8, 2016).
    • Goodman, CR, Sato, T, Peck, AR, Girondo, MA, Yang, N, Liu, C, Yanac, AF, Kovatich, AJ, Hooke, JA, Shriver, CD, Mitchell, EP, Hyslop, T, and Rui, H. "Steroid induction of therapy-resistant cytokeratin-5-positive cells in estrogen receptor-positive breast cancer through a BCL6-dependent mechanism." Oncogene 35, no. 11 (March 2016): 1373-1385.  Full Text
    • Palumbo, A, Michael, Y, and Hyslop, T. "Latent class model characterization of neighborhood socioeconomic status." Cancer causes & control : CCC 27, no. 3 (March 2016): 445-452.  Full Text
    • He, K, Li, Y, Zhu, J, Liu, H, Lee, JE, Amos, CI, Hyslop, T, Jin, J, Lin, H, Wei, Q, and Li, Y. "Component-wise gradient boosting and false discovery control in survival analysis with high-dimensional covariates." Bioinformatics (Oxford, England) 32, no. 1 (January 2016): 50-57.  Full Text  Open Access Copy
    • Lin, JE, Colon-Gonzalez, F, Blomain, E, Kim, GW, Aing, A, Stoecker, B, Rock, J, Snook, AE, Zhan, T, Hyslop, TM, Tomczak, M, Blumberg, RS, and Waldman, SA. "Obesity-Induced Colorectal Cancer Is Driven by Caloric Silencing of the Guanylin-GUCY2C Paracrine Signaling Axis." Cancer research 76, no. 2 (January 2016): 339-346.  Full Text
    • Mu, Z, Wang, C, Ye, Z, Austin, L, Civan, J, Hyslop, T, Palazzo, JP, Jaslow, R, Li, B, Myers, RE, Jiang, J, Xing, J, Yang, H, and Cristofanilli, M. "Prospective assessment of the prognostic value of circulating tumor cells and their clusters in patients with advanced-stage breast cancer." Breast cancer research and treatment 154, no. 3 (December 2015): 563-571.  Full Text
    • Adam, MA, Pura, J, Goffredo, P, Dinan, MA, Reed, SD, Scheri, RP, Hyslop, T, Roman, SA, and Sosa, JA. "Presence and Number of Lymph Node Metastases Are Associated With Compromised Survival for Patients Younger Than Age 45 Years With Papillary Thyroid Cancer." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 33, no. 21 (July 2015): 2370-2375.  Full Text
    • Showalter, TN, Hegarty, SE, Rabinowitz, C, Maio, V, Hyslop, T, Dicker, AP, and Louis, DZ. "Assessing adverse events of postprostatectomy radiation therapy for prostate cancer: evaluation of outcomes in the Regione Emilia-Romagna, Italy." International journal of radiation oncology, biology, physics 91, no. 4 (March 2015): 752-759.  Full Text
    • Adam, MA, Pura, J, Goffredo, P, Dinan, MA, Hyslop, T, Reed, SD, Scheri, RP, Roman, SA, and Sosa, JA. "Impact of extent of surgery on survival for papillary thyroid cancer patients younger than 45 years." The Journal of Clinical Endocrinology and Metabolism 100, no. 1 (January 2015): 115-121.  Full Text
    • Adam, MA, Pura, J, Goffredo, P, Dinan, MA, Hyslop, T, Reed, SD, Scheri, RP, Roman, SA, and Sosa, JA. "Impact of extent of surgery on survival for papillary thyroid cancer patients younger than 45 years." Journal of Clinical Endocrinology and Metabolism 100, no. 1 (2015): 115-121.  Full Text
    • Hegarty, SE, Hyslop, T, Dicker, AP, and Showalter, TN. "Radiation therapy after radical prostatectomy for prostate cancer: evaluation of complications and influence of radiation timing on outcomes in a large, population-based cohort." PLoS ONE 10, no. 2 (January 2015): e0118430-.  Full Text
    • Lin, J, Deng, A, Hoffman-Censits, J, Gibney, G, Hyslop, T, Miller, B, Kilpatrick, D, Jabbour, S, and Kevin Kelly, W. "An open label randomized phase II study of pasireotide with or without everolimus in castrate-resistant chemotherapy-naïve prostate cancer patients." Cancer Treatment Communications 4 (2015): 192-195.  Full Text
    • Wang, C, Civan, J, Lai, Y, Cristofanilli, M, Hyslop, T, Palazzo, JP, Myers, RE, Li, B, Ye, Z, Zhang, K, Xing, J, and Yang, H. "Racial disparity in breast cancer survival: the impact of pre-treatment hematologic variables." Cancer causes & control : CCC 26, no. 1 (January 2015): 45-56.  Full Text
    • Zhang, K, Lai, Y, Axelrod, R, Campling, B, Hyslop, T, Civan, J, Solomides, C, Myers, RE, Lu, B, Bar Ad, V, Li, B, Ye, Z, and Yang, H. "Modeling the overall survival of patients with advanced-stage non-small cell lung cancer using data of routine laboratory tests." International Journal of Cancer 136, no. 2 (January 1, 2015): 382-391.  Full Text
    • Wilson, C, Lin, JE, Li, P, Snook, AE, Gong, J, Sato, T, Liu, C, Girondo, MA, Rui, H, Hyslop, T, and Waldman, SA. "The paracrine hormone for the GUCY2C tumor suppressor, guanylin, is universally lost in colorectal cancer." Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 23, no. 11 (November 2014): 2328-2337.  Full Text
    • Chen, Y, Kovatich, AJ, Fantacone-Campbell, JL, Hooke, JA, Kvecher, L, Kovatich, AW, Gallagher, CM, Hueman, MT, Hyslop, T, Mural, RJ, Shriver, CD, Rui, H, and Hu, H. "Abstract P4-06-09: HER2+ and HER2- luminal B subtypes have similar overall survival and histologic grade distributions." Cancer Research 73, no. 24 Supplement (December 15, 2013): P4-06-09-P4-06-09.  Full Text
    • Girondo, MA, Peck, AR, Freydin, B, Chervoneva, I, Hyslop, T, Kovatich, AJ, Hooke, JA, Shriver, CD, Mitchell, EP, and Rui, H. "Abstract P1-08-20: Increased risk of hormone therapy failure in breast cancers expressing low phospho-Stat5: Validation of quantitative immunofluorescence assay parameters." Cancer Research 73, no. 24 Supplement (December 15, 2013): P1-08-20-P1-08-20.  Full Text
    • Kovatich, AJ, Chen, Y, Fantacone-Campbell, JL, Wareham, JA, Tafra, L, Kvecher, L, Hyslop, T, Hooke, JA, Rui, H, Shriver, CD, Mural, RJ, and Hu, H. "Abstract P4-06-03: Assays on core biopsies and surgically resected tumors may result in different subtyping of the invasive breast cancer from the same patient:." Cancer Research 73, no. 24 Supplement (December 15, 2013): P4-06-03-P4-06-03.  Full Text
    • Hyslop, T, Michael, Y, Avery, T, and Rui, H. "Population and target considerations for triple-negative breast cancer clinical trials." Biomarkers in medicine 7, no. 1 (February 2013): 11-21. (Review)  Full Text
    • Lin, JE, Snook, AE, Li, P, Stoecker, BA, Kim, GW, Magee, MS, Garcia, AVM, Valentino, MA, Hyslop, T, Schulz, S, and Waldman, SA. "GUCY2C opposes systemic genotoxic tumorigenesis by regulating AKT-dependent intestinal barrier integrity." PloS one 7, no. 2 (January 2012): e31686-.  Full Text
    • Peck, AR, Witkiewicz, AK, Liu, C, Stringer, GA, Klimowicz, AC, Pequignot, E, Freydin, B, Tran, TH, Yang, N, Rosenberg, AL, Hooke, JA, Kovatich, AJ, Nevalainen, MT, Shriver, CD, Hyslop, T, Sauter, G, Rimm, DL, Magliocco, AM, and Rui, H. "Loss of nuclear localized and tyrosine phosphorylated Stat5 in breast cancer predicts poor clinical outcome and increased risk of antiestrogen therapy failure." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 29, no. 18 (June 2011): 2448-2458.  Full Text
    • Chervoneva, I, Li, Y, Schulz, S, Croker, S, Wilson, C, Waldman, SA, and Hyslop, T. "Selection of optimal reference genes for normalization in quantitative RT-PCR." BMC bioinformatics 11 (May 14, 2010): 253-.  Full Text
    • Lin, JE, Li, P, Snook, AE, Schulz, S, Dasgupta, A, Hyslop, TM, Gibbons, AV, Marszlowicz, G, Pitari, GM, and Waldman, SA. "The Hormone Receptor GUCY2C Suppresses Intestinal Tumor Formation by Inhibiting AKT Signaling." GASTROENTEROLOGY 138, no. 1 (January 2010): 241-254.  Full Text  Link to Item
    • Waldman, SA, Hyslop, T, Schulz, S, Barkun, A, Nielsen, K, Haaf, J, Bonaccorso, C, Li, Y, and Weinberg, DS. "Association of GUCY2C expression in lymph nodes with time to recurrence and disease-free survival in pN0 colorectal cancer." JAMA 301, no. 7 (February 2009): 745-752.  Full Text
    • Yu, Z, Wang, C, Wang, M, Li, Z, Casimiro, MC, Liu, M, Wu, K, Whittle, J, Ju, X, Hyslop, T, McCue, P, and Pestell, RG. "A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation." The Journal of cell biology 182, no. 3 (August 2008): 509-517.  Full Text
    • Chervoneva, I, Li, Y, Iglewicz, B, Waldman, S, and Hyslop, T. "Relative quantification based on logistic models for individual polymerase chain reactions." Statistics in medicine 26, no. 30 (December 2007): 5596-5611.  Full Text
    • Calin, GA, Liu, C-G, Ferracin, M, Hyslop, T, Spizzo, R, Sevignani, C, Fabbri, M, Cimmino, A, Lee, EJ, Wojcik, SE, Shimizu, M, Tili, E, Rossi, S, Taccioli, C, Pichiorri, F, Liu, X, Zupo, S, Herlea, V, Gramantieri, L, Lanza, G, Alder, H, Rassenti, L, Volinia, S, Schmittgen, TD, Kipps, TJ, Negrini, M, and Croce, CM. "Ultraconserved regions encoding ncRNAs are altered in human leukemias and carcinomas." Cancer cell 12, no. 3 (September 2007): 215-229.  Full Text
    • Chervoneva, I, Iglewicz, B, and Hyslop, T. "A general approach for two-stage analysis of multilevel clustered non-Gaussian data." Biometrics 62, no. 3 (September 2006): 752-759.  Full Text
    • Calin, GA, Sevignani, C, Dumitru, CD, Hyslop, T, Noch, E, Yendamuri, S, Shimizu, M, Rattan, S, Bullrich, F, Negrini, M, and Croce, CM. "Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers." Proceedings of the National Academy of Sciences of the United States of America 101, no. 9 (March 2004): 2999-3004.  Full Text
    • Ober, C, Hyslop, T, Elias, S, Weitkamp, LR, and Hauck, WW. "Human leukocyte antigen matching and fetal loss: results of a 10 year prospective study." Human reproduction (Oxford, England) 13, no. 1 (January 1998): 33-38.  Full Text

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