Timothy Joseph McMahon | Scholars@Duke

Timothy Joseph McMahon
Professor of Medicine

The McMahon Lab at Duke University and Durham VA Medical Center is investigating novel roles of the red blood cell (RBC) in the circulation. The regulated release of the vasodilator SNO (a form of NO, nitric oxide) by RBCs within the respiratory cycle in mammals optimizes nutrient delivery at multiple levels, especially in the lung (gas exchange) and the peripheral microcirculation (O₂ transport to tisses). Deficiency of RBC SNO bioactivity (as in human RBCs banked for transfusion), for example, appears to contribute to the serious lung and circulatory problems associated with RBC transfusion in some settings. We have also demonstrated benefit in the use of treatments that exploit RBCs as a vehicle for delivery of SNOs, in both human patients and in model animals.

RBCs also release ATP in response to stimuli including deformation and hypoxia, and the exported ATP also participates in the maintenance of a healthy circulation, according to mechanisms that we are now unraveling.

We use basic and translational approaches to understand the molecular mechanisms by which these RBC-derived signals effect circulatory changes in human health and disease, particularly in the lung. Disease states driving this research include acute and chronic lung diseases such as sepsis (severe infection), transfusion-related respiratory problems, sickle cell disease, and pulmonary hypertension of adults and newborns.

Funding: VA and NIH.

Current Appointments & Affiliations

Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 2017

Contact Information

DUMC 2650, 203 Research Drive, Durham, NC 27710
Msrb1, Rm 275, DUMC 2650, 203 Research Drive, Durham, NC 27710
tim.mcmahon@duke.edu (919) 668-7762

Background
Education, Training, & Certifications
- Pulmonary Fellow, Medicine, Duke University 1996 - 1999
- Medical Resident, Medicine, Duke University 1993 - 1996
- M.D., Tulane University 1993
- Ph.D., Tulane University 1992
Duke Appointment History
- Associate Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 2010 - 2017
- Associate Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 2006 - 2010
- Assistant Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 1999 - 2006
Research
Selected Grants
- Duke CTSA (KL2) awarded by National Institutes of Health 2018 - 2023
- Duke CTSA (TL1) awarded by National Institutes of Health 2018 - 2023
- Role of S-nitrosothiols in Akt1 signaling and pneumonia resolution awarded by National Institutes of Health 2017 - 2021
- Transfusion Medicine and Hematology awarded by National Institutes of Health 1975 - 2021
- Interdisciplinary Training Program in Lung Disease awarded by National Institutes of Health 2009 - 2020
- Sepsis-induced Red Cell Dysfunction (SiRD) awarded by Washington University 2015 - 2020
- S-nitrosothiols, NF-KappaB and Inflammation in Acute Lung Injury awarded by National Institutes of Health 2014 - 2019
- Novel role for CD163 in ozone induced alterations of pulmonary immunity awarded by East Carolina University 2018 - 2019
- IPA - Joseph Herbert awarded by Durham Veterans Affairs Medical Center 2018 - 2019
- Hand-held advanced functional imager for assessing local tissue oxygenation awarded by Wasatch Photonics, Inc. 2017 - 2018
- Evaluation of endothelial function in single ventricle patients receiving Ambrisentan after surgery. awarded by Thrasher Research Fund 2015 - 2017
- Blood flow and tissue oxygenation using optical coherence tomography awarded by Wasatch Photonics, Inc. 2016
- The Duke Multidisciplinary Training Program in Pediatric Lung Disease awarded by National Institutes of Health 2010 - 2016
- Role of RBC NO and ATP in Sickle Vasculopathy awarded by National Institutes of Health 2012 - 2016
- Impaired release of antiadhesive ATP from stored RBCs: a novel transfusion lesion awarded by National Institutes of Health 2012 - 2014
- Pulmonary Hypertension in SCD awarded by National Institutes of Health 2005 - 2011
- Red Blood Cell S-nitrosothiols and Oxygenation awarded by National Institutes of Health 2009
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Zhang, L, Wu, J-H, Huang, T-Q, Nepliouev, I, Brian, L, Zhang, Z, Wertman, V, Rudemiller, NP, McMahon, TJ, Shenoy, SK, Miller, FJ, Crowley, SD, Freedman, NJ, and Stiber, JA. "Drebrin regulates angiotensin II-induced aortic remodelling." Cardiovascular Research 114, no. 13 (November 2018): 1806-1815. Full Text
  - Rogers, SC, Dosier, LB, McMahon, TJ, Zhu, H, Timm, D, Zhang, H, Herbert, J, Atallah, J, Palmer, GM, Cook, A, Ernst, M, Prakash, J, Terng, M, Towfighi, P, Doctor, R, Said, A, Joens, MS, Fitzpatrick, JAJ, Hanna, G, Lin, X, Reisz, JA, Nemkov, T, D'Alessandro, A, and Doctor, A. "Red blood cell phenotype fidelity following glycerol cryopreservation optimized for research purposes." Plos One 13, no. 12 (January 2018): e0209201-null. Full Text
  - Vostal, JG, Buehler, PW, Gelderman, MP, Alayash, AI, Doctor, A, Zimring, JC, Glynn, SA, Hess, JR, Klein, H, Acker, JP, Spinella, PC, D'Alessandro, A, Palsson, B, Raife, TJ, Busch, MP, McMahon, TJ, Intaglietta, M, Swartz, HM, Dubick, MA, Cardin, S, Patel, RP, Natanson, C, Weisel, JW, Muszynski, JA, Norris, PJ, and Ness, PM. "Proceedings of the Food and Drug Administration's public workshop on new red blood cell product regulatory science 2016." Transfusion 58, no. 1 (January 2018): 255-266. Full Text
  - McMahon, TJ, and Bryan, NS. "Biomarkers in Pulmonary Vascular Disease: Gauging Response to Therapy." The American journal of cardiology 120, no. 8S (October 2017): S89-S95. (Review) Full Text
  - Dosier, LBM, Premkumar, VJ, Zhu, H, Akosman, I, Wempe, MF, and McMahon, TJ. "Antagonists of the system L neutral amino acid transporter (LAT) promote endothelial adhesivity of human red blood cells." Thrombosis and Haemostasis 117, no. 7 (June 2017): 1402-1411. Full Text
  - Pastva, AM, Walker, JK, Maddox, LA, Mukherjee, S, Giamberardino, C, Hsia, B, Potts, E, Zhu, H, Degan, S, Sunday, ME, Lawson, BL, Korfhagen, TR, Schwartz, DA, Eu, JP, Foster, WM, McMahon, TJ, Que, L, and Wright, JR. "Nitric Oxide Mediates Relative Airway Hyporesponsiveness to Lipopolysaccharide in Surfactant Protein A-Deficient Mice (Retraction of vol 44, pg 175, 2011)." AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY 55, no. 5 (November 2016): 758-758. Link to Item
  - Riccio, DA, Malowitz, JR, Cotten, CM, Murtha, AP, and McMahon, TJ. "S-Nitrosylated fetal hemoglobin in neonatal human blood." Biochemical and biophysical research communications 473, no. 4 (May 2016): 1084-1089. Full Text
  - McMahon, TJ. "Platelets promote pulmonary pull of polys." Blood 126, no. 19 (November 2015): 2174-2175. Full Text
  - Riccio, DA, Zhu, H, Foster, MW, Huang, B, Hofmann, CL, Palmer, GM, and McMahon, TJ. "Renitrosylation of banked human red blood cells improves deformability and reduces adhesivity." Transfusion 55, no. 10 (October 2015): 2452-2463. Full Text
  - Kirby, BS, Schwarzbaum, PJ, Lazarowski, ER, Dinenno, FA, and McMahon, TJ. "Liberation of ATP secondary to hemolysis is not mutually exclusive of regulated export." Blood 125, no. 11 (March 2015): 1844-1845. (Letter) Full Text
  - Riccio, DA, Zhu, H, Foster, MW, Huang, B, Hofmann, CL, Palmer, GM, and McMahon, TJ. "Renitrosylation of banked human red blood cells improves deformability and reduces adhesivity." Transfusion 55, no. 10 (2015): 2452-2463. Full Text
  - Kirby, BS, Hanna, G, Hendargo, HC, and McMahon, TJ. "Restoration of intracellular ATP production in banked red blood cells improves inducible ATP export and suppresses RBC-endothelial adhesion." American Journal of Physiology. Heart and Circulatory Physiology 307, no. 12 (December 2014): H1737-H1744. Full Text
  - Bennett-Guerrero, E, Kirby, BS, Zhu, H, Herman, AE, Bandarenko, N, and McMahon, TJ. "Randomized study of washing 40- to 42-day-stored red blood cells." Transfusion 54, no. 10 (October 2014): 2544-2552. Full Text
  - Foster, MW, Thompson, JW, Forrester, MT, Sha, Y, McMahon, TJ, Bowles, DE, Moseley, MA, and Marshall, HE. "Proteomic analysis of the NOS2 interactome in human airway epithelial cells." Nitric Oxide 34 (November 2013): 37-46. Full Text
  - Foster, MW, Thompson, JW, Forrester, MT, Sha, Y, McMahon, TJ, Bowles, DE, Moseley, MA, and Marshall, HE. "Proteomic analysis of the NOS2 interactome in human airway epithelial cells." Nitric Oxide 34 (November 1, 2013): 37-46. Full Text Link to Item
  - Lilly, LE, Blinebry, SK, Viscardi, CM, Perez, L, Bonaventura, J, and McMahon, TJ. "Parallel assay of oxygen equilibria of hemoglobin." Analytical Biochemistry 441, no. 1 (October 2013): 63-68. Full Text
  - Hanna, G, Fontanella, A, Palmer, G, Shan, S, Radiloff, DR, Zhao, Y, Irwin, D, Hamilton, K, Boico, A, Piantadosi, CA, Blueschke, G, Dewhirst, M, McMahon, T, and Schroeder, T. "Automated measurement of blood flow velocity and direction and hemoglobin oxygen saturation in the rat lung using intravital microscopy." American Journal of Physiology. Lung Cellular and Molecular Physiology 304, no. 2 (January 2013): L86-L91. Full Text
  - Nossaman, BD, Pankey, EA, McMahon, T, and Kadowitz, PJ. "The clinical role of soluble guanylyl cyclase stimulators." Current Topics in Pharmacology 17, no. 2 (January 1, 2013): 1-12. (Review)
  - Roberson, RS, Lockhart, E, Shapiro, NI, Bandarenko, N, McMahon, TJ, Massey, MJ, White, WD, and Bennett-Guerrero, E. "Impact of transfusion of autologous 7- versus 42-day-old AS-3 red blood cells on tissue oxygenation and the microcirculation in healthy volunteers." Transfusion 52, no. 11 (November 2012): 2459-2464. Full Text
  - Torok, JA, Brahmajothi, MV, Zhu, H, Tinch, BT, Auten, RL, and McMahon, TJ. "Transpulmonary flux of S-nitrosothiols and pulmonary vasodilation during nitric oxide inhalation: role of transport." Am J Respir Cell Mol Biol 47, no. 1 (July 2012): 37-43. Full Text Link to Item
  - Piantadosi, CA, Bartz, RR, Carraway, MS, Ghio, AJ, McMahon, TJ, Murdoch, DM, Roggli, VL, Shofer, SL, Tighe, RM, Welty-Wolf, KE, and Young, SL. "The opprobrium of Big Tobacco." Am J Respir Crit Care Med 185, no. 9 (May 1, 2012): 1030-. (Letter) Full Text Link to Item
  - Ibrahim, YI, Ninnis, JR, Hopper, AO, Deming, DD, Zhang, AX, Herring, JL, Sowers, LC, McMahon, TJ, Power, GG, and Blood, AB. "Inhaled nitric oxide therapy increases blood nitrite, nitrate, and s-nitrosohemoglobin concentrations in infants with pulmonary hypertension." J Pediatr 160, no. 2 (February 2012): 245-251. Full Text Link to Item
  - Zhu, H, Zennadi, R, Xu, BX, Eu, JP, Torok, JA, Telen, MJ, and McMahon, TJ. "Impaired adenosine-5'-triphosphate release from red blood cells promotes their adhesion to endothelial cells: a mechanism of hypoxemia after transfusion." Critical Care Medicine 39, no. 11 (November 2011): 2478-2486. Full Text
  - "The Main Players: Hemoglobin and Myoglobin; Nitric Oxide and Oxygen." (July 4, 2011): 47-62. (Chapter) Full Text
  - Zhu, H, Zennadi, R, Xu, B, Eu, JP, Torok, J, Telen, MJ, and McMahon, TJ. "Red Blood Cell Release Of ATP Prevents Endothelial Adhesion: Implications For Post-Transfusion Lung Dysfunction." AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 183 (2011). Link to Item
  - Brahmajothi, MV, Mason, SN, Whorton, AR, McMahon, TJ, and Auten, RL. "Transport rather than diffusion-dependent route for nitric oxide gas activity in alveolar epithelium." Free Radic Biol Med 49, no. 2 (July 15, 2010): 294-300. Full Text Link to Item
  - McMahon, TJ. "Functional and Biochemical Changes in Stored Human Red Blood Cells." BLOOD 112, no. 11 (November 16, 2008): 1355-1355. Link to Item
  - Granillo, OM, Brahmajothi, MV, Li, S, Whorton, AR, Mason, SN, McMahon, TJ, and Auten, RL. "Pulmonary alveolar epithelial uptake of S-nitrosothiols is regulated by L-type amino acid transporter." American Journal of Physiology. Lung Cellular and Molecular Physiology 295, no. 1 (July 2008): L38-L43. Full Text
  - Bennett-Guerrero, E, Veldman, TH, Doctor, A, Telen, MJ, Ortel, TL, Reid, TS, Mulherin, MA, Zhu, H, Buck, RD, Califf, RM, and McMahon, TJ. "Evolution of adverse changes in stored RBCs." Proceedings of the National Academy of Sciences of the United States of America 104, no. 43 (October 11, 2007): 17063-17068. Full Text
  - Sonveaux, P, Lobysheva, II, Feron, O, and McMahon, TJ. "Transport and peripheral bioactivities of nitrogen oxides carried by red blood cell hemoglobin: role in oxygen delivery." Physiology (Bethesda, Md.) 22 (April 2007): 97-112. (Review) Full Text
  - Du, W, McMahon, TJ, Zhang, Z-S, Stiber, JA, Meissner, G, and Eu, JP. "Excitation-contraction coupling in airway smooth muscle." J Biol Chem 281, no. 40 (October 6, 2006): 30143-30151. Full Text Link to Item
  - McMahon, TJ, and Doctor, A. "Extrapulmonary effects of inhaled nitric oxide: role of reversible S-nitrosylation of erythrocytic hemoglobin." Proceedings of the American Thoracic Society 3, no. 2 (April 2006): 153-160. (Review) Full Text
  - Roggli, VL, Piantadosi, CA, MacIntyre, NR, Young, SL, Kussin, PS, Steele, MP, Carraway, MS, Welty-Wolf, KE, Govert, JA, McMahon, TJ, Palmer, SM, Sporn, TA, and Ghio, AJ. "Physician subsidies for tobacco advertising." Am J Respir Crit Care Med 173, no. 2 (January 15, 2006): 246-. (Letter) Full Text Link to Item
  - Nozik-Grayck, E, Whalen, EJ, Stamler, JS, McMahon, TJ, Chitano, P, and Piantadosi, CA. "S-nitrosoglutathione inhibits alpha1-adrenergic receptor-mediated vasoconstriction and ligand binding in pulmonary artery." American Journal of Physiology. Lung Cellular and Molecular Physiology 290, no. 1 (January 2006): L136-L143. Full Text
  - Sonveaux, P, McMahon, TJ, Stamler, JS, Feron, O, and Dewhirst, MW. "Oxygen regulation of tumor perfusion by S-nitrosohemoglobin: Implications for radiotherapy." ACTA CLINICA BELGICA 61, no. 2 (2006): 95-95. Link to Item
  - Du, W, Frazier, M, McMahon, TJ, and Eu, JP. "Redox activation of intracellular calcium release channels (ryanodine receptors) in the sustained phase of hypoxia-induced pulmonary vasoconstriction." Chest 128, no. 6 Suppl (December 2005): 556S-558S. Full Text Link to Item
  - McMahon, TJ, Ahearn, GS, Moya, MP, Gow, AJ, Huang, Y-CT, Luchsinger, BP, Nudelman, R, Yan, Y, Krichman, AD, Bashore, TM, Califf, RM, Singel, DJ, Piantadosi, CA, Tapson, VF, and Stamler, JS. "A nitric oxide processing defect of red blood cells created by hypoxia: deficiency of S-nitrosohemoglobin in pulmonary hypertension." Proceedings of the National Academy of Sciences of the United States of America 102, no. 41 (October 3, 2005): 14801-14806. Full Text
  - Brandler, MD, Powell, SC, Craig, DM, Quick, G, McMahon, TJ, Goldberg, RN, and Stamler, JS. "A novel inhaled organic nitrate that affects pulmonary vascular tone in a piglet model of hypoxia-induced pulmonary hypertension." Pediatr Res 58, no. 3 (September 2005): 531-536. Full Text Link to Item
  - Sonveaux, P, Kaz, AM, Snyder, SA, Richardson, RA, Cárdenas-Navia, LI, Braun, RD, Pawloski, JR, Tozer, GM, Bonaventura, J, McMahon, TJ, Stamler, JS, and Dewhirst, MW. "Oxygen regulation of tumor perfusion by S-nitrosohemoglobin reveals a pressor activity of nitric oxide." Circ Res 96, no. 10 (May 27, 2005): 1119-1126. Full Text Link to Item
  - Doctor, A, Platt, R, Sheram, ML, Eischeid, A, McMahon, T, Maxey, T, Doherty, J, Axelrod, M, Kline, J, Gurka, M, Gow, A, and Gaston, B. "Hemoglobin conformation couples erythrocyte S-nitrosothiol content to O2 gradients." Proceedings of the National Academy of Sciences of the United States of America 102, no. 16 (April 11, 2005): 5709-5714. Full Text
  - Liu, L, Yan, Y, Zeng, M, Zhang, J, Hanes, MA, Ahearn, G, McMahon, TJ, Dickfeld, T, Marshall, HE, Que, LG, and Stamler, JS. "Essential roles of S-nitrosothiols in vascular homeostasis and endotoxic shock." Cell 116, no. 4 (February 2004): 617-628. Full Text
  - McMahon, TJ. "Hemoglobin and nitric oxide." N Engl J Med 349, no. 4 (July 24, 2003): 402-405. (Letter) Link to Item
  - McMahon, TJ. "Hemoglobin and nitric oxide." NEW ENGLAND JOURNAL OF MEDICINE 349, no. 4 (July 24, 2003): 403-403. Link to Item
  - Stamler, JS. "Hemoglobin and nitric oxide." N Engl J Med 349, no. 4 (July 24, 2003): 402-405. (Letter) Full Text Link to Item
  - McMahon, TJ, Pawloski, JR, Hess, DT, Piantadosi, CA, Luchsinger, BP, Singel, DJ, and Stamler, JS. "S-nitrosohemoglobin is distinguished from other nitrosovasodilators by unique oxygen-dependent responses that support an allosteric mechanism of action." Blood 102, no. 1 (July 1, 2003): 410-411. (Letter) Full Text Link to Item
  - Foster, MW, McMahon, TJ, and Stamler, JS. "S-nitrosylation in health and disease." Trends in Molecular Medicine 9, no. 4 (April 2003): 160-168. (Review) Full Text
  - McMahon, TJ, Moon, RE, Luschinger, BP, Carraway, MS, Stone, AE, Stolp, BW, Gow, AJ, Pawloski, JR, Watke, P, Singel, DJ, Piantadosi, CA, and Stamler, JS. "Nitric oxide in the human respiratory cycle." Nature Medicine 8, no. 7 (July 2002): 711-717. Full Text
  - Nozik-Grayck, E, McMahon, TJ, Huang, Y-CT, Dieterle, CS, Stamler, JS, and Piantadosi, CA. "Pulmonary vasoconstriction by serotonin is inhibited by S-nitrosoglutathione." American Journal of Physiology. Lung Cellular and Molecular Physiology 282, no. 5 (May 2002): L1057-L1065. Full Text
  - Archibald, JD, Mummery, HJ, McMahon, TJ, Piantadosi, CA, Stamler, JS, El-Moalem, H, and Moon, RE. "Time-related increase in hypoxic pulmonary vasoconstriction (HPV) in humans." CIRCULATION 104, no. 17 (October 23, 2001): 249-249. Link to Item
  - McMahon, TJ, Gow, AJ, Huang, YCT, Pawloski, JR, and Stamler, JS. "Modulation of hypoxic pulmonary vasoconstriction by erythrocytic nitric oxide." CIRCULATION 104, no. 17 (October 23, 2001): 248-248. Link to Item
  - Moya, MP, Gow, AJ, McMahon, TJ, Toone, EJ, Cheifetz, IM, Goldberg, RN, and Stamler, JS. "S-nitrosothiol repletion by an inhaled gas regulates pulmonary function." Proc Natl Acad Sci U S A 98, no. 10 (May 8, 2001): 5792-5797. Full Text Link to Item
  - McMahon, TJ, Gow, AJ, Moya, MP, Moon, RE, Tapson, VF, Ahearn, GS, Stone, AE, Krichman, A, Carraway, MS, Piantadosi, CA, and Stamler, JS. "Nitric oxide in the respiratory cycle in human health and disease." FREE RADICAL BIOLOGY AND MEDICINE 31 (2001): S71-S71. Link to Item
  - Pawloski, JR, Hess, DT, McMahon, TJ, and Stamler, JS. "Oxygen-dependent export of nitric oxide from red blood cells." BLOOD 96, no. 11 (November 16, 2000): 596A-+. Link to Item
  - McMahon, TJ, Stone, AE, Bonaventura, J, Singel, DJ, and Stamler, JS. "Functional coupling of oxygen binding and vasoactivity in S-nitrosohemoglobin." The Journal of Biological Chemistry 275, no. 22 (June 2000): 16738-16745. Full Text
  - McMahon, TJ, Stone, AE, Bonaventura, J, and Stamler, JS. "S-nitrosylation of hemoglobin increases its oxygen affinity." AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 159, no. 3 (March 1999): A352-A352. Link to Item
  - McMahon, TJ, Stone, AE, Bonaventura, J, Singel, DJ, and Stamler, JS. "Thermodynamic linkage relationships in S-nitrosohemoglobin: Oxygen binding and vasoactivity." FREE RADICAL BIOLOGY AND MEDICINE 27 (1999): S81-S81. Link to Item
  - McMahon, TJ, and Stamler, JS. "Concerted nitric oxide/oxygen delivery by hemoglobin." Methods Enzymol 301 (1999): 99-114. Link to Item
  - Channon, KM, Qian, H, Neplioueva, V, Blazing, MA, Olmez, E, Shetty, GA, Youngblood, SA, Pawloski, J, McMahon, T, Stamler, JS, and George, SE. "In vivo gene transfer of nitric oxide synthase enhances vasomotor function in carotid arteries from normal and cholesterol-Fed rabbits." Circulation 98, no. 18 (November 3, 1998): 1905-1911. Link to Item
  - Moon, RE, Watke, PL, Stolp, BW, Lawler, WL, Dear, GD, Hart, BB, Robertson, PW, McMahon, TJ, Carraway, MS, and Piantadosi, CS. "The effect of hyperbaric oxygen on pulmonary vascular tone." ANESTHESIOLOGY 89, no. 3A (September 1998): U1045-U1045. Link to Item
  - Gaston, B, Sears, S, Woods, J, Hunt, J, Ponaman, M, McMahon, T, and Stamler, JS. "Bronchodilator S-nitrosothiol deficiency in asthmatic respiratory failure." Lancet 351, no. 9112 (May 2, 1998): 1317-1319. Full Text Link to Item
  - Channon, KM, Qian, HS, Neplioueva, V, Blazing, MA, Olmez, E, Shetty, GA, Pawloski, J, Mc Mahon, T, Stamler, JS, and George, SE. "Nitric oxide synthase gene transfer corrects deficient endothelial vasmotor function in hypercholesterolaemic rabbits." Heart 79, no. SUPPL. 1 (May 1, 1998).
  - Stamler, JS, Jia, L, Eu, JP, McMahon, TJ, Demchenko, IT, Bonaventura, J, Gernert, K, and Piantadosi, CA. "Blood flow regulation by S-nitrosohemoglobin in the physiological oxygen gradient." Science (New York, N.Y.) 276, no. 5321 (June 1997): 2034-2037. Full Text
  - Channon, KM, Blazing, MA, Pawloski, J, McMahon, T, Olmez, E, Shetty, GA, Stamler, JS, and George, SE. "In vivo adenoviral gene transfer of nitric oxide synthase augments or restores vascular no production." Heart 77, no. SUPPL. 1 (May 1, 1997).
  - DeWitt, BJ, Cheng, DY, McMahon, TJ, Marrone, JR, Champion, HC, and Kadowitz, PJ. "Effects of U-37883A, a vascular selective K(ATP)/+ channel antagonist, in the pulmonary and hindlimb circulation." American Journal of Physiology Lung Cellular and Molecular Physiology 271, no. 6 15-6 (December 1, 1996).
  - DeWitt, BJ, Cheng, DY, McMahon, TJ, Marrone, JR, Champion, HC, and Kandowitz, PJ. "Effects of U-37883A, a vascular selective KATP+ channel antagonist, in the pulmonary and hindlimb circulation." The American Journal of Physiology 271, no. 6 Pt 1 (December 1996): L924-L931. Full Text
  - Minkes, RK, Santiago, JA, McMahon, TJ, and Kadowitz, PJ. "Role of K(ATP)/+ channels and EDRF in reactive hyperemia in the hindquarters vascular bed of cats." American Journal of Physiology Heart and Circulatory Physiology 269, no. 5 38-5 (December 15, 1995).
  - Minkes, RK, Santiago, JA, McMahon, TJ, and Kadowitz, PJ. "Role of K+ATP channels and EDRF in reactive hyperemia in the hindquarters vascular bed of cats." The American Journal of Physiology 269, no. 5 Pt 2 (November 1995): H1704-H1712. Full Text
  - Cheng, DY, DeWitt, BJ, McMahon, TJ, and Kadowitz, PJ. "Comparative effects of L-NNA and alkyl esters of L-NNA on pulmonary vasodilator responses to ACh, BK, and SP." The American Journal of Physiology 266, no. 6 Pt 2 (June 1994): H2416-H2422. Full Text
  - Cheng, DY, DeWitt, BJ, McMahon, TJ, and Kadowitz, PJ. "Comparison of pressor responses to angiotensin I, II, and III in pulmonary vascular bed of cats." The American Journal of Physiology 266, no. 6 Pt 2 (June 1994): H2247-H2255. Full Text
  - DeWitt, BJ, Cheng, DY, McMahon, TJ, Nossaman, BD, and Kadowitz, PJ. "Analysis of responses to bradykinin in the pulmonary vascular bed of the cat." The American Journal of Physiology 266, no. 6 Pt 2 (June 1994): H2256-H2267. Full Text
  - Cheng, DY, DeWitt, BJ, McMahon, TJ, and Kadowitz, PJ. "Comparison of pressor responses to angiotensin I, II, and III in pulmonary vascular bed of cats." American Journal of Physiology Heart and Circulatory Physiology 266, no. 6 35-6 (January 1, 1994).
  - Cheng, DY, DeWitt, BJ, McMahon, TJ, and Kadowitz, PJ. "Comparative effects of L-NNA and alkyl esters of L-NNA on pulmonary vasodilator responses to ACh, BK, and SP." American Journal of Physiology Heart and Circulatory Physiology 266, no. 6 35-6 (January 1, 1994).
  - DeWitt, BJ, Cheng, DY, McMahon, TJ, Nossaman, BD, and Kadowitz, PJ. "Analysis of responses to bradykinin in the pulmonary vascular bed of the cat." American Journal of Physiology - Heart and Circulatory Physiology 266, no. 6 35-6 (1994): H2256-H2267.
  - Cheng, DY, McMahon, TJ, Dewitt, BJ, Carroll, GC, Lee, SS, Murphy, WA, Bitar, KG, Coy, DH, and Kadowitz, PJ. "Comparison of responses to pituitary adenylate cyclase activating peptides 38 and 27 in the pulmonary vascular bed of the cat." Eur J Pharmacol 243, no. 1 (October 12, 1993): 79-82. Link to Item
  - McMahon, TJ, Hood, JS, Nossaman, BD, and Kadowitz, PJ. "Analysis of responses to serotonin in the pulmonary vascular bed of the cat." Journal of Applied Physiology (Bethesda, Md. : 1985) 75, no. 1 (July 1993): 93-102. Full Text
  - McMahon, TJ, Ignarro, LJ, and Kadowitz, PJ. "Influence of Zaprinast on vascular tone and vasodilator responses in the cat pulmonary vascular bed." Journal of Applied Physiology (Bethesda, Md. : 1985) 74, no. 4 (April 1993): 1704-1711. Full Text
  - McMahon, TJ, and Kadowitz, PJ. "Analysis of responses to substance P in the pulmonary vascular bed of the cat." The American Journal of Physiology 264, no. 2 Pt 2 (February 1993): H394-H402. Full Text
  - McMahon, TJ, and Kadowitz, PJ. "Analysis of responses to substance P in the pulmonary vascular bed of the cat." American Journal of Physiology Heart and Circulatory Physiology 264, no. 2 33-2 (January 1, 1993).
  - Minkes, RK, McMahon, TJ, Higuera, TR, Murphy, WA, Coy, DH, and Kadowitz, PJ. "Analysis of systemic and pulmonary vascular responses to PACAP and VIP: role of adrenal catecholamines." The American Journal of Physiology 263, no. 6 Pt 2 (December 1992): H1659-H1669. Full Text
  - Minkes, RK, McMahon, TJ, Higuera, TR, Murphy, WA, Coy, DH, and Kadowitz, PJ. "Analysis of systemic and pulmonary vascular responses to PACAP and VIP: Role of adrenal catecholamines." American Journal of Physiology Heart and Circulatory Physiology 263, no. 6 32-6 (December 1, 1992).
  - McMahon, TJ, Kaye, AD, Hood, JS, Minkes, RK, Nossaman, BD, and Kadowitz, PJ. "Inhibitory effects of DuP 753 and EXP3174 on responses to angiotensin II in pulmonary vascular bed of the cat." Journal of Applied Physiology (Bethesda, Md. : 1985) 73, no. 5 (November 1992): 2054-2061. Full Text
  - McMahon, TJ, and Kadowitz, PJ. "Methylene blue inhibits neurogenic cholinergic vasodilator responses in the pulmonary vascular bed of the cat." The American Journal of Physiology 263, no. 5 Pt 1 (November 1992): L575-L584. Full Text
  - Tamura, DY, Minkes, RK, Bellan, JA, McMahon, TJ, McNamara, DB, and Kadowitz, PJ. "Analysis of responses to big endothelin in the hindquarters vascular bed of the cat." Can J Cardiol 8, no. 9 (November 1992): 954-960. Link to Item
  - Bellan, JA, Minkes, RK, Hood, JS, McMahon, TJ, Higuera, TR, Nossaman, BD, McNamara, DB, and Kadowitz, PJ. "Analysis of pulmonary and systemic vascular responses to platelet-activating factor in the cat." The American Journal of Physiology 263, no. 1 Pt 2 (July 1992): H234-H243. Full Text
  - Hood, JS, Nossaman, BD, Ibrahim, IN, McMahon, TJ, Babycos, CR, and Kadowitz, PJ. "Daltroban blocks thromboxane responses in the pulmonary vascular bed of the cat." Journal of Applied Physiology (Bethesda, Md. : 1985) 72, no. 6 (June 1992): 2305-2310. Full Text
  - Nossaman, BD, McMahon, TJ, Ragheb, MS, Ibrahim, IN, Babycos, CR, Hood, JS, and Kadowitz, PJ. "Blockade of thromboxane/endoperoxide receptor-mediated responses in the pulmonary vascular bed of the cat by sulotroban." Eur J Pharmacol 213, no. 1 (March 17, 1992): 1-7. Link to Item
  - McMahon, TJ, Hood, JS, Nossaman, BD, Hyman, AL, and Kadowitz, PJ. "Characterization of thromboxane receptor blocking effects of SQ 29548 in the feline pulmonary vascular bed." Journal of Applied Physiology (Bethesda, Md. : 1985) 72, no. 3 (March 1992): 1194-1200. Full Text
  - Minkes, RK, McMahon, TJ, Hood, JS, Murphy, WA, Coy, DH, McNamara, DB, and Kadowitz, PJ. "Differential effects of PACAP and VIP on the pulmonary and hindquarters vascular beds of the cat." Journal of Applied Physiology (Bethesda, Md. : 1985) 72, no. 3 (March 1992): 1212-1217. Full Text
  - McMahon, TJ, Hood, JS, and Kadowitz, PJ. "Pulmonary vasodilator response to vagal stimulation is blocked by N omega-nitro-L-arginine methyl ester in the cat." Circ Res 70, no. 2 (February 1992): 364-369. Link to Item
  - Bellan, JA, Minkes, RK, Hood, JS, McMahon, TJ, Higuera, TR, Nossaman, BD, McNamara, DB, and Kadowitz, PJ. "Analysis of pulmonary and systemic vascular responses to platelet- activating factor in the cat." American Journal of Physiology Heart and Circulatory Physiology 263, no. 1 32-1 (January 1, 1992).
  - McMahon, TJ, and Kadowitz, PJ. "Methylene blue inhibits neurogenic cholinergic vasodilator responses in the pulmonary vascular bed of the cat." American Journal of Physiology Lung Cellular and Molecular Physiology 263, no. 5 7-5 (January 1, 1992).
  - McMahon, TJ, Hood, JS, Bellan, JA, and Kadowitz, PJ. "N omega-nitro-L-arginine methyl ester selectively inhibits pulmonary vasodilator responses to acetylcholine and bradykinin." Journal of Applied Physiology (Bethesda, Md. : 1985) 71, no. 5 (November 1991): 2026-2031. Full Text
  - McMahon, TJ, Hood, JS, Nossaman, BD, Ibrahim, IN, Feng, CJ, and Kadowitz, PJ. "Influence of SQ 30741 on thromboxane receptor-mediated responses in the feline pulmonary vascular bed." Journal of Applied Physiology (Bethesda, Md. : 1985) 71, no. 5 (November 1991): 2012-2018. Full Text
  - McMahon, TJ, Hood, JS, and Kadowitz, PJ. "Analysis of responses to sarafotoxin 6a and sarafotoxin 6c in the pulmonary vascular bed of the cat." Journal of Applied Physiology (Bethesda, Md. : 1985) 71, no. 5 (November 1991): 2019-2025. Full Text
  - Minkes, RK, Bellan, JA, McMahon, TJ, McNamara, DB, and Kadowitz, PJ. "Influence of SQ 29,548 on vasoconstrictor responses in the hindquarters vascular bed of the cat." Prostaglandins, Leukotrienes, and Essential Fatty Acids 44, no. 2 (October 1991): 83-88. Full Text
  - Hood, JS, McMahon, TJ, and Kadowitz, PJ. "Influence of lemakalim on the pulmonary vascular bed of the cat." Eur J Pharmacol 202, no. 1 (September 4, 1991): 101-104. Link to Item
  - Hood, JS, McMahon, TJ, and Kadowitz, PJ. "Pulmonary vasodilator responses to RP 52891 are mediated by activation of a glibenclamide-sensitive K+ATP channel." Eur J Pharmacol 202, no. 1 (September 4, 1991): 121-124. Link to Item
  - Kadowitz, PJ, McMahon, TJ, Hood, JS, Feng, CJ, Minkes, RK, and Dyson, MC. "Pulmonary vascular and airway responses to endothelin-1 are mediated by different mechanisms in the cat." J Cardiovasc Pharmacol 17 Suppl 7 (1991): S374-S377. Link to Item
  - McMahon, TJ, Hood, JS, Bellan, JA, and Kadowitz, PJ. "N(ω)-nitro-L-arginine methyl ester selectively inhibits pulmonary vasodilator responses to acetylcholine and bradykinin." Journal of Applied Physiology 71, no. 5 (January 1, 1991): 2026-2031.
  - Oas, TG, Hartzell, CJ, Mcmahon, TJ, Drobny, GP, and Dahlauist, FW. "The Carbonyl ¹³C Chemical Shift Tensors of Five Peptides Determined from ¹⁵N Dipole-Coupled Chemical Shift Powder Patterns." Journal of the American Chemical Society 109, no. 20 (September 1, 1987): 5956-5962. Full Text
  - Nozik-Grayck, E, McMahon, TJ, Huang, YCT, Dieterle, CS, Stamler, JS, and Piantadosi, CA. "Pulmonary vasoconstriction by serotonin is inhibited by S-nitrosoglutathione." American Journal of Physiology Lung Cellular and Molecular Physiology 282, no. 5 26-5 (June 29, 2002).
- Conference Papers
  - Gowdy, KM, Reece, SW, Cuddapah, KL, Kilburg-Basnyat, B, Psaltis, C, Hondros, A, McMahon, TJ, Zeczycki, T, and Tighe, RM. "CD163 Protects Against Ozone Increased Susceptibility to Bacterial Pneumonia." International Conference of the American-Thoracic-Society. San Diego, CA. May 18, 2018 - May 23, 2018.: AMER THORACIC SOC, January 1, 2018. Link to Item
  - Swaminathan, A, Lokhnygina, Y, Zhu, H, Kennedy, K, Mason, SN, Kelleher, Z, Fee, B, Poms, A, Tapson, VF, and McMahon, TJ. "Asymmetric Dimethylarginine and Symmetric Dimethylarginine as Novel Biomarkers in Patients with Pulmonary (Arterial) Hypertension." International Conference of the American-Thoracic-Society. San Diego, CA. May 18, 2018 - May 23, 2018.: AMER THORACIC SOC, January 1, 2018. Link to Item
  - Dosier, LBM, Zhu, H, Zhang, H, Palmer, G, and McMahon, TJ. "The Role Of L-Amino Acid Transporter (lat-1) In The Hypoxia-Induced Export Of Anti-Adhesive S-Nitrosothiols (snos)." International Conference of the American-Thoracic-Society (ATS). Washington, DC. May 19, 2017 - May 24, 2017.: AMER THORACIC SOC, January 1, 2017. Link to Item
  - Zhu, H, Hill, SE, Caswell, J, and McMahon, TJ. "Red Blood Cell Hemoglobin-Bound Nitric Oxide In Human Blood Stored For Acute Normovolemic Hemodilution (anh)." International Conference of the American-Thoracic-Society (ATS). Washington, DC. May 19, 2017 - May 24, 2017.: AMER THORACIC SOC, January 1, 2017. Link to Item
  - Dosier, LBM, Zhu, H, and McMahon, TJ. "Inhibition Of L-Type Amino Acid Transporter 1 (lat-1) Export Of S-Nitrosothiols (sno) Promotes Red Blood Cell Adhesion To Endothelial Cells." 2016. Link to Item
  - Swaminathan, AC, Poms, A, Kennedy, K, Zhu, H, Gaspard, E, Fortin, TA, Senick, J, Parikh, K, Kelleher, ZT, Fee, B, Rajagopal, S, Murray, K, Tapson, V, McMahon, TJ, and Circulation, P. "Toward Theranostic Biomarkers In Pulmonary Hypertension." 2016. Link to Item
  - Zhu, H, Riccio, D, Kirby, B, and McMahon, TJ. "Effect Of Red Blood Cell Atp Augmentation On Post-Transfusion Rbc Extravasation And Changes In Oxygenation In LPS-Exposed Mice." 2013. Link to Item
  - Riccio, DA, and McMahon, TJ. "Reversing a red blood cell storage (RBCS) lesion: S-Nitrosothiol replenishment in aged RBCS." : Elsevier BV, July 2012. Full Text
  - Sonveaux, P, Feron, O, McMahon, TJ, Stamler, JS, and Dewhirst, MW. "C34. Oxygen regulation of tumor perfusion unravels the central pressor activity of cell-free human S-nitrosohemoglobin." : Elsevier BV, 2007. Full Text
  - Pawloski, JR, McMahon, TJ, Ahearne, G, Piantadosi, CA, Singel, DJ, and Stamler, JS. "Hypoxic vasodilation by red blood cells and impairment in vascular disorders." November 16, 2004. Link to Item
  - Pawloski, JR, McMahon, TJ, Moya, MP, Gow, AJ, Huang, YCT, Luchsinger, BJ, Krichman, AD, Bashore, TM, Califf, RM, Singel, DJ, Piantadosi, CA, Tapson, VF, and Stamler, JS. "Red blood cell S-nitrosohemoglobin deficiency in pulmonary arterial hypertension." November 16, 2004. Link to Item
  - Liu, LM, Yan, Y, Zeng, M, Zhang, J, Hanes, MA, Ahearn, G, McMahon, TJ, Dickfeld, T, Marshall, HE, Que, LG, and Stamler, JS. "Essential roles of S-nitrosothiols in vascular homeostasis and endotoxic shock." August 2004. Link to Item
Teaching & Mentoring
Recent Courses
- MEDICINE 406C: Intensive Care Medicine Sub-Internship (Durham VA Hospital) 2019
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