Tim McCord

Journal Article Front Cardiovasc Med · 2023 Skeletal muscle injury in peripheral artery disease (PAD) has been attributed to vascular insufficiency, however evidence has demonstrated that muscle cell responses play a role in determining outcomes in limb ischemia. Here, we demonstrate that genetic ab ... Full text Link to item Cite

VEGF-C and VE-cadherin: balancing sinusoidal and lymphatic angiogenesis.

Journal Article Nat Cardiovasc Res · November 2022 Full text Link to item Cite

Coupled myovascular expansion directs cardiac growth and regeneration.

Journal Article Development · September 15, 2022 Featured Publication Heart regeneration requires multiple cell types to enable cardiomyocyte (CM) proliferation. How these cells interact to create growth niches is unclear. Here, we profile proliferation kinetics of cardiac endothelial cells (CECs) and CMs in the neonatal mou ... Full text Link to item Cite

Coupled myovascular expansion directs cardiac growth and regeneration

Journal Article · 2021 ABSTRACTBackground Heart regeneration requires multiple cell types to enable cardiomyocyte (CM) proliferation. How these cells interact to create growth niches is unclear. Here we profile proliferation kinetics of cardiac endothelial cel ... Full text Cite

Single-Cell Transcriptomic Analysis Identifies Differences in Skeletal Muscle Macrophages in a Human Critical Limb Ischemia Patient and a Murine Model of Hindlimb Ischemia

Conference ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY · 2020 Cite

Myoepithelial Cells of Submucosal Glands Can Function as Reserve Stem Cells to Regenerate Airways after Injury.

Journal Article Cell Stem Cell · May 3, 2018 Featured Publication Cells demonstrate plasticity following injury, but the extent of this phenomenon and the cellular mechanisms involved remain underexplored. Using single-cell RNA sequencing (scRNA-seq) and lineage tracing, we uncover that myoepithelial cells (MECs) of the ... Full text Link to item Cite

BAG3 (Bcl-2-Associated Athanogene-3) Coding Variant in Mice Determines Susceptibility to Ischemic Limb Muscle Myopathy by Directing Autophagy.

Journal Article Circulation · July 18, 2017 Featured Publication BACKGROUND: Critical limb ischemia is a manifestation of peripheral artery disease that carries significant mortality and morbidity risk in humans, although its genetic determinants remain largely unknown. We previously discovered 2 overlapping quantitativ ... Full text Link to item Cite

Subacute limb ischemia induces skeletal muscle injury in genetically susceptible mice independent of vascular density.

Journal Article J Vasc Surg · October 2016 Featured Publication OBJECTIVE: The primary preclinical model of peripheral artery disease, which involves acute limb ischemia (ALI), can result in appreciable muscle injury that is attributed to the acuity of the ischemic injury. A less acute model of murine limb ischemia usi ... Full text Link to item Cite

Methods for Acute and Subacute Murine Hindlimb Ischemia.

Journal Article J Vis Exp · June 21, 2016 Featured Publication Peripheral artery disease (PAD) is a leading cause of cardiovascular morbidity and mortality in developed countries, and animal models that reliably reproduce the human disease are necessary to develop new therapies for this disease. The mouse hindlimb isc ... Full text Link to item Cite

Akb-9785, A Ve-Ptp Inhibitor, Decreases Inflammation And Alters The Angiopoietin/tie2 System Dynamic Response In A S. Aureus Sepsis Model

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2016 Featured Publication Link to item Cite

Muscle cell derived angiopoietin-1 contributes to both myogenesis and angiogenesis in the ischemic environment.

Journal Article Front Physiol · 2015 Featured Publication Recent strategies to treat peripheral arterial disease (PAD) have focused on stem cell based therapies, which are believed to result in local secretion of vascular growth factors. Little is known, however, about the role of ischemic endogenous cells in thi ... Full text Link to item Cite

Skeletal muscle-specific genetic determinants contribute to the differential strain-dependent effects of hindlimb ischemia in mice.

Journal Article Am J Pathol · May 2012 Featured Publication Genetics plays an important role in determining peripheral arterial disease (PAD) pathology, which causes a spectrum of clinical disorders that range from clinically silent reductions in blood flow to limb-threatening ischemia. The cell-type specificity of ... Full text Link to item Cite