Current Appointments & Affiliations
Professor of Orthopaedic Surgery
·
2021 - Present
Orthopaedic Surgery, Physical Therapy,
Orthopaedic Surgery
Member of Duke Molecular Physiology Institute
·
2022 - Present
Duke Molecular Physiology Institute,
Institutes and Centers
Recent Publications
Cardiac Transplantation Does Not Improve Exercise Tolerance, Muscle Mass, or Substrate Metabolism in Barth Syndrome.
Journal Article JIMD Rep · July 2025 Barth syndrome (BTHS) is a rare X-linked recessive disorder characterized by mutations in the TAFAZZIN gene, leading to mitochondrial dysfunction, cardioskeletal myopathy, neutropenia, exercise intolerance, and growth delay. While cardiac transplantation c ... Full text Link to item CiteRescue of mitochondrial dysfunction through alteration of extracellular matrix composition in barth syndrome cardiac fibroblasts.
Journal Article Biomaterials · April 2025 Fibroblast-ECM (dys)regulation is associated with a plethora of diseases. The ECM acts as a reservoir of inflammatory factors and cytokines that mediate molecular mechanisms within cardiac cell populations. The role of ECM-mitochondria crosstalk in the dev ... Full text Link to item CiteFeasibility of a community-based structured exercise program for persons with spinal cord injury.
Journal Article J Spinal Cord Med · March 2025 OBJECTIVES: (1) Examine the feasibility of a community-based exercise intervention for persons with spinal cord injury and (2) compare the cardiorespiratory fitness, skeletal muscle strength, and psychosocial well-being of participants in the intervention ... Full text Link to item CiteRecent Grants
Real world use of anti-obesity medications to treat adolescent obesity: moving beyond the clinical trial
ResearchCo Investigator · Awarded by National Institutes of Health · 2025 - 2029Wheelchair user physical activity training intervention to enhance cardiometabolic health (WATCH): A community-based randomized control trial
ResearchPrincipal Investigator · Awarded by Washington University in St. Louis · 2023 - 2027Cardiac and Skeletal Muscle Myofilament Activators for the Treatment of Barth Syndrome
ResearchCo-Principal Investigator · Awarded by Barth Syndrome Foundation · 2024 - 2026View All Grants
Education, Training & Certifications
University of Maryland, School of Medicine ·
2002
Ph.D.
University of Miami ·
1994
M.S.
University of Maryland, College Park ·
1991
B.S.