William Todd Cade
Professor of Orthopaedic Surgery

Current Research Interests

Exercise and Cardiometabolic Health

Overall, our laboratory aims to study mechanisms of and treatments (nutritional/exercise/pharmacologic/gene therapy) for abnormalities in cardiometabolic disease, focusing on substrate (e.g. amino acid, glucose, fatty acid) metabolism, energetic, and functional abnormalities in skeletal muscle, heart, adipose tissue, liver and brain. We study metabolic diseases including: Barth syndrome and other pediatric and adult cardiomyopathies, HIV-related metabolic syndrome, diabetes mellitus, and obesity. We are also interested in the effect of the maternal metabolic environment during pregnancy on in utero development and childhood metabolic disease including obesity, diabetes, and HIV. We are in particularly interested in the use of exercise as a tool to study and intervention to improve metabolism and function in these conditions. Our lab employs methodology used to measure whole-body substrate metabolism by stable isotope tracers and mass spectrometry, myocardial substrate metabolism by radio-isotopes and PET imaging, heart and skeletal muscle energetics by magnetic resonance spectroscopy (MRS), peak fitness assessment by graded exercise testing and indirect calorimetry, cardiac function by echocardiography, vascular function by peripheral arterial tonometry and applanation tonometry, body composition analysis by dual-energy x-ray absorptiometry (DXA) and air displacement plethymosgraphy, muscle strength by isokinetic dynamometry, and daily physical activity by actigraphy.

Current Appointments & Affiliations

Contact Information

  • 311 Trent Drive, Durham, NC 27710
  • 311 Trent Drive, Durham, NC 27710

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