Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Fellowship, Cardiovascular Medicine, Duke University School of Medicine 2007 - 2011
  • Resident, Internal Medicine, Stanford University School of Medicine 2005 - 2007
  • Intern, Internal Medicine, Stanford University School of Medicine 2004 - 2005
  • M.D., Louisiana State University 2004
  • Ph.D., Tulane University 2001
  • B.S., Louisiana State University 1996
• 

  Duke Appointment History

  • Assistant Professor of Medicine, Medicine, Cardiology, Medicine 2012 - 2018
• Research
• 

  Selected Grants

  • PORTICO awarded by St. Jude Medical Inc. 2014 - 2022
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Fudim, Marat, Arun Ganesh, Cindy Green, W Schuyler Jones, Michael A. Blazing, Adam D. DeVore, G Michael Felker, et al. “Splanchnic nerve block for decompensated chronic heart failure: splanchnic-HF..” European Heart Journal 39, no. 48 (December 2018): 4255–56. https://doi.org/10.1093/eurheartj/ehy682.
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    • Inohara, Taku, Pratik Manandhar, Andrzej S. Kosinski, Roland A. Matsouaka, Shun Kohsaka, Robert J. Mentz, Vinod H. Thourani, et al. “Association of Renin-Angiotensin Inhibitor Treatment With Mortality and Heart Failure Readmission in Patients With Transcatheter Aortic Valve Replacement..” Jama 320, no. 21 (December 2018): 2231–41. https://doi.org/10.1001/jama.2018.18077.
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    • Pineda, Andrés M., and Todd L. Kiefer. “Asymptomatic Severe Aortic Valve Stenosis-When to Intervene: a Review of the Literature, Current Trials, and Guidelines..” Current Cardiology Reports 20, no. 12 (October 11, 2018). https://doi.org/10.1007/s11886-018-1072-x.
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    • Sherwood, Matthew W., and Todd L. Kiefer. “Challenges in Aortic Valve Stenosis: Low-Flow States Diagnosis, Management, and a Review of the Current Literature..” Current Cardiology Reports 19, no. 12 (October 30, 2017). https://doi.org/10.1007/s11886-017-0941-z.
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    • Kochar, Ajar, and Todd Kiefer. “Coronary Artery Anomalies: When You Need to Worry..” Current Cardiology Reports 19, no. 5 (May 2017). https://doi.org/10.1007/s11886-017-0854-x.
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    • Kiefer, Todd L., John Vavalle, Lynne M. Hurwitz, G Chad Hughes, and J Kevin Harrison. “Resolution of severe hemolysis and paravalvular aortic regurgitation employing an Amplatzer Vascular Plug 4: the importance of detailed pre-procedural planning using CT angiography..” Cardiovascular Intervention and Therapeutics 32, no. 1 (January 2017): 48–52. https://doi.org/10.1007/s12928-015-0363-z.
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    • Klein, Michael R., Todd L. Kiefer, and Eric J. Velazquez. “Platypnea-Orthodeoxia Syndrome: To Shunt or Not to Shunt, That is the Question..” Texas Heart Institute Journal 43, no. 3 (June 2016): 264–66. https://doi.org/10.14503/THIJ-15-5280.
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    • Vemulapalli, Sreekanth, Lynne M. Hurwitz Koweek, Todd L. Kiefer, Kevin P. Jackson, and Jonathan P. Piccini. “Left atrial appendage to great cardiac vein fistula complicating watchman left atrial appendage closure..” European Heart Journal 37, no. 20 (May 2016). https://doi.org/10.1093/eurheartj/ehv609.
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    • Wang, Hanghang, Jennifer M. Hanna, Asvin Ganapathi, Jeffrey E. Keenan, Lynne M. Hurwitz, John P. Vavalle, Todd L. Kiefer, Andrew Wang, J Kevin Harrison, and G Chad Hughes. “Comparison of aortic annulus size by transesophageal echocardiography and computed tomography angiography with direct surgical measurement..” The American Journal of Cardiology 115, no. 11 (June 2015): 1568–73. https://doi.org/10.1016/j.amjcard.2015.02.060.
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    • Walker, Wendy L., Daniel T. Boll, Juliana M. Bueno, Todd L. Kiefer, John P. Vavalle, Jeffrey G. Gaca, J Kevin Harrison, G Chad Hughes, Andrew Wang, and Lynne M. Hurwitz. “Assessment of single-bolus contrast administration technique using hybrid dual-source ECG-gated thoracic and dual-source non-ECG-gated high-pitch abdominopelvic CT acquisitions for procedural planning before transcatheter aortic valve replacement..” Journal of Computer Assisted Tomography 39, no. 2 (March 2015): 207–12. https://doi.org/10.1097/rct.0000000000000194.
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    • Walker, W. L., D. T. Boll, J. M. Bueno, T. L. Kiefer, J. P. Vavalle, J. G. Gaca, J. K. Harrison, G. C. Hughes, A. Wang, and L. M. Hurwitz. “Assessment of single-bolus contrast administration technique using hybrid dual-source ECG-gated thoracic and dual-source non-ECG-gated high-pitch abdominopelvic CT acquisitions for procedural planning before transcatheter aortic valve replacement.” Journal of Computer Assisted Tomography 39, no. 2 (January 1, 2015): 207–12. https://doi.org/10.1097/RCT.0000000000000194.
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    • Kiefer, Todd L., Andrew Wang, and J Kevin Harrison. “Invasive hemodynamic evaluation in patients with mechanical aortic valves. Catheterization and cardiovascular interventions: official journal of the society for cardiac angiography & interventions 2013..” Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions 84, no. 5 (November 2014): 853–54. https://doi.org/10.1002/ccd.25067.
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    • Vora, Amit N., Thomas Gehrig, Thomas M. Bashore, and Todd L. Kiefer. “Treatment of mechanical aortic valve thrombosis with heparin and eptifibatide..” J Thromb Thrombolysis 38, no. 1 (July 2014): 73–77. https://doi.org/10.1007/s11239-014-1055-8.
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    • Rohrhoff, N., J. P. Vavalle, S. Halim, T. L. Kiefer, and J. K. Harrison. “Current status of percutaneous PFO closure..” Current Cardiology Reports 16, no. 5 (May 2014). https://doi.org/10.1007/s11886-014-0477-4.
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    • Vavalle, John P., Todd L. Kiefer, Carmelo A. Milano, J Kevin Harrison, and G Chad Hughes. “Transcatheter aortic valve replacement performed via left ventricular assist device inflow cannula..” Circulation. Heart Failure 7, no. 3 (May 2014): 544–46. https://doi.org/10.1161/circheartfailure.114.001232.
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    • Kiefer, Todd L., John P. Vavalle, Adam Devore, Chetan B. Patel, Joseph Rogers, Carmelo Milano, Thomas R. Gehrig, and J Kevin Harrison. “Ascending aorta to main pulmonary artery fistula following orthotopic heart transplantation: successful percutaneous closure employing an Amplatzer Duct Occluder..” Jacc. Cardiovascular Interventions 7, no. 3 (March 2014): e25–27. https://doi.org/10.1016/j.jcin.2013.07.015.
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    • Schlendorf, Kelly, Chetan B. Patel, Thomas Gehrig, Todd L. Kiefer, G Michael Felker, Adrian F. Hernandez, Laura J. Blue, Carmelo A. Milano, and Joseph G. Rogers. “Thrombolytic therapy for thrombosis of continuous flow ventricular assist devices..” J Card Fail 20, no. 2 (February 2014): 91–97. https://doi.org/10.1016/j.cardfail.2013.12.011.
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    • Kiefer, T. L., A. Wang, and J. K. Harrison. “Letter to the editor.” Catheterization and Cardiovascular Interventions 84, no. 5 (2014): 853–54. https://doi.org/10.1002/ccd.25067.
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    • Kiefer, Todd L., G Chad Hughes, Jeffrey Chad Johnson, and J Kevin Harrison. “Aortic subannular left ventricular aneurysm: a rare and surgically correctable cause of angina..” The Annals of Thoracic Surgery 97, no. 1 (January 2014): 313–15. https://doi.org/10.1016/j.athoracsur.2013.04.130.
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    • Rohrhoff, N., J. P. Vavalle, S. Halim, T. L. Kiefer, and J. K. Harrison. “Current status of percutaneous PFO closure.” Current Cardiology Reports 16, no. 5 (January 1, 2014). https://doi.org/10.1007/s11886-014-0477-4.
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    • Vora, A. N., T. Gehrig, T. M. Bashore, and T. L. Kiefer. “Treatment of mechanical aortic valve thrombosis with heparin and eptifibatide.” Journal of Thrombosis and Thrombolysis 38, no. 1 (January 1, 2014): 73–77. https://doi.org/10.1007/s11239-014-1055-8.
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    • Ong, Daniel S., Robert A. Aertker, Alexandra N. Clark, Todd Kiefer, G Chad Hughes, J Kevin Harrison, and Thomas M. Bashore. “Radiation-associated valvular heart disease..” The Journal of Heart Valve Disease 22, no. 6 (November 2013): 883–92.
    • Kiefer, Todd L., John Vavalle, Sharif Halim, Prashant Kaul, J Larry Klein, Lynne H. Hurwitz, Jeffrey G. Gaca, and J Kevin Harrison. “Anterograde percutaneous coronary-cameral fistula closure employing a guide-in-guide technique..” Jacc. Cardiovascular Interventions 6, no. 10 (October 2013): 1105–7. https://doi.org/10.1016/j.jcin.2013.03.023.
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    • Kiefer, Todd L., Andrew Wang, and J Kevin Harrison. “Invasive hemodynamic evaluation in patients with mechanical aortic valves..” Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions 82, no. 1 (July 2013): 43–50. https://doi.org/10.1002/ccd.24738.
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    • Halim, Sharif A., Todd L. Kiefer, G Chad Hughes, Lynne M. Hurwitz, and J Kevin Harrison. “Transcatheter aortic valve replacement: an update..” Current Cardiology Reports 15, no. 6 (June 2013). https://doi.org/10.1007/s11886-013-0367-1.
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    • Kiefer, T. L., A. Wang, and J. K. Harrison. “Invasive hemodynamic evaluation in patients with mechanical aortic valves.” Catheterization and Cardiovascular Interventions 82, no. 1 (2013): 43–50. https://doi.org/10.1002/ccd.24738.
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    • Kiefer, Todd L., Anna Lisa Crowley, James Jaggers, and J Kevin Harrison. “Coronary arteriovenous fistulae: the complexity of coronary artery-to-coronary sinus connections..” Texas Heart Institute Journal 39, no. 2 (January 2012): 218–22.
    • Kiefer, Todd L., and Thomas M. Bashore. “Infective endocarditis: a comprehensive overview..” Reviews in Cardiovascular Medicine 13, no. 2–3 (January 2012): e105–20.
    • Kiefer, Todd L., Andrew Wang, G Chad Hughes, and Thomas M. Bashore. “Management of patients with bicuspid aortic valve disease..” Current Treatment Options in Cardiovascular Medicine 13, no. 6 (December 2011): 489–505. https://doi.org/10.1007/s11936-011-0152-7.
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    • Patel, Sanjay, Todd L. Kiefer, Aijaz Ahmed, Ziad A. Ali, Jennifer A. Tremmel, David P. Lee, Alan C. Yeung, and William F. Fearon. “Comparison of the frequency of coronary artery disease in alcohol-related versus non-alcohol-related endstage liver disease..” The American Journal of Cardiology 108, no. 11 (December 2011): 1552–55. https://doi.org/10.1016/j.amjcard.2011.07.013.
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    • Kiefer, Todd, Lawrence Park, Christophe Tribouilloy, Claudia Cortes, Roberta Casillo, Vivian Chu, Francois Delahaye, et al. “Association between valvular surgery and mortality among patients with infective endocarditis complicated by heart failure..” Jama 306, no. 20 (November 23, 2011): 2239–47. https://doi.org/10.1001/jama.2011.1701.
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    • Kiefer, Todd L., and Thomas M. Bashore. “Pulmonary hypertension related to left-sided cardiac pathology..” Pulmonary Medicine 2011 (January 2011). https://doi.org/10.1155/2011/381787.
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    • Kiefer, Todd L., and Richard C. Becker. “Inhibitors of platelet adhesion..” Circulation 120, no. 24 (December 2009): 2488–95. https://doi.org/10.1161/circulationaha.109.886895.
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    • Melancon, K., Q. Cheng, T. L. Kiefer, J. Dai, L. Lai, C. Dong, L. Yuan, et al. “Regression of NMU-induced mammary tumors with the combination of melatonin and 9-cis-retinoic acid..” Cancer Letters 227, no. 1 (September 2005): 39–48. https://doi.org/10.1016/j.canlet.2005.01.005.
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    • Kiefer, Todd L., Ling Lai, Lin Yuan, Chunmin Dong, Matthew E. Burow, and Steven M. Hill. “Differential regulation of estrogen receptor alpha, glucocorticoid receptor and retinoic acid receptor alpha transcriptional activity by melatonin is mediated via different G proteins..” Journal of Pineal Research 38, no. 4 (May 2005): 231–39. https://doi.org/10.1111/j.1600-079x.2004.00198.x.
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    • Collins, A., L. Yuan, T. L. Kiefer, Q. Cheng, L. Lai, and S. M. Hill. “Overexpression of the MT1 melatonin receptor in MCF-7 human breast cancer cells inhibits mammary tumor formation in nude mice..” Cancer Letters 189, no. 1 (January 2003): 49–57. https://doi.org/10.1016/s0304-3835(02)00502-5.
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    • Ram, P. T., J. Dai, L. Yuan, C. Dong, T. L. Kiefer, L. Lai, and S. M. Hill. “Involvement of the mt1 melatonin receptor in human breast cancer..” Cancer Letters 179, no. 2 (May 2002): 141–50. https://doi.org/10.1016/s0304-3835(01)00873-4.
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    • Nowfar, S., S. R. Teplitzky, K. Melancon, T. L. Kiefer, Q. Cheng, P. D. Dwived, E. D. Bischoff, et al. “Tumor prevention by 9-cis-retinoic acid in the N-nitroso-N-methylurea model of mammary carcinogenesis is potentiated by the pineal hormone melatonin..” Breast Cancer Research and Treatment 72, no. 1 (March 2002): 33–43. https://doi.org/10.1023/a:1014912919470.
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    • Kiefer, T., P. T. Ram, L. Yuan, and S. M. Hill. “Melatonin inhibits estrogen receptor transactivation and cAMP levels in breast cancer cells..” Breast Cancer Research and Treatment 71, no. 1 (January 2002): 37–45. https://doi.org/10.1023/a:1013301408464.
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    • Teplitzky, S. R., T. L. Kiefer, Q. Cheng, P. D. Dwivedi, K. Moroz, L. Myers, M. B. Anderson, et al. “Chemoprevention of NMU-induced rat mammary carcinoma with the combination of melatonin and 9-cis-retinoic acid..” Cancer Letters 168, no. 2 (July 2001): 155–63. https://doi.org/10.1016/s0304-3835(01)00548-1.
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    • Ram, P. T., L. Yuan, J. Dai, T. Kiefer, D. M. Klotz, L. L. Spriggs, and S. M. Hill. “Differential responsiveness of MCF-7 human breast cancer cell line stocks to the pineal hormone, melatonin..” Journal of Pineal Research 28, no. 4 (May 2000): 210–18. https://doi.org/10.1034/j.1600-079x.2000.280403.x.
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    • Cohn, C. S., J. A. Sullivan, T. Kiefer, and S. M. Hill. “Identification of an enhancer element in the estrogen receptor upstream region: implications for regulation of ER transcription in breast cancer..” Molecular and Cellular Endocrinology 158, no. 1–2 (December 1999): 25–36. https://doi.org/10.1016/s0303-7207(99)00187-2.
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    • Hill, S. M., S. Teplitzky, P. T. Ram, T. Kiefer, D. E. Blask, L. L. Spriggs, and K. M. Eck. “Melatonin synergizes with retinoic acid in the prevention and regression of breast cancer..” Advances in Experimental Medicine and Biology 460 (January 1999): 345–62.
    • Ram, P. T., T. Kiefer, M. Silverman, Y. Song, G. M. Brown, and S. M. Hill. “Estrogen receptor transactivation in MCF-7 breast cancer cells by melatonin and growth factors..” Molecular and Cellular Endocrinology 141, no. 1–2 (June 1998): 53–64. https://doi.org/10.1016/s0303-7207(98)00095-1.
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  • Book Sections

    • Kiefer, T. L., and A. Wang. “Infective endocarditis.” In Evidence-Based Cardiology Consult, 9781447144410:71–78, 2014. https://doi.org/10.1007/978-1-4471-4441-0_6.
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    • Kiefer, T., and M. V. Podgoreanu. “Cardiac receptors.” In Core Topics in Cardiac Anesthesia, Second Edition, 39–47, 2012. https://doi.org/10.1017/CBO9780511979095.013.
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  • Other Articles

    • Kiefer, Todd L., Sharif Halim, Andrew Wang, J. Kevin Harrison, Jeffrey Gaca, and G Chad Hughes. “Fluoroscopic characterization of surgical bioprosthetic heart valves..” Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions, June 2015. https://doi.org/10.1002/ccd.25904.
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  • Conference Papers

    • Sherwood, Matthew W., Sreekanth Vemulapalli, Amit N. Vora, David D. Dai, Sharif Halim, Todd L. Kiefer, G Charles Hughes, J Kevin Harrison, and Eric D. Peterson. “National Variation in Post-tavr Antithrombotic Therapy Utilization in Patients With Atrial Fibrillation: Insights From the Sts/acc Tvt Registry (R).” In Circulation, Vol. 132. LIPPINCOTT WILLIAMS & WILKINS, 2015.
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