Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Fellowship, Cardiovascular Medicine, Duke University School of Medicine 2007 - 2011
  • Resident, Internal Medicine, Stanford University, School of Medicine 2005 - 2007
  • Intern, Internal Medicine, Stanford University, School of Medicine 2004 - 2005
  • M.D., Louisiana State University 2004
  • Ph.D., Tulane University 2001
  • B.S., Louisiana State University 1996
• 

  Previous Appointments & Affiliations

  • Assistant Professor of Medicine, Medicine, Cardiology, Medicine 2012 - 2018
• Research
• 

  Selected Grants

  • Portico Re-sheathable Transcatheter Aortic Valve System US IDE Trial (PORTICO) awarded by St. Jude Medical Inc. 2014 - 2023
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Barnett, Adam S., Todd Kiefer, Han W. Kim, Mark Mitchell, Kevin P. Jackson, Jonathan P. Piccini, Jason I. Koontz, and Albert Y. Sun. “Ablation of Ventricular Tachycardia Storm With Coronary Venous Ethanol.” Jacc Clin Electrophysiol 7, no. 5 (May 2021): 682–83. https://doi.org/10.1016/j.jacep.2021.01.005.
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    • Fudim, Marat, Richard L. Boortz-Marx, Arun Ganesh, Adam D. DeVore, Chetan B. Patel, Joseph G. Rogers, Aubrie Coburn, et al. “Splanchnic Nerve Block for Chronic Heart Failure.” Jacc Heart Fail 8, no. 9 (September 2020): 742–52. https://doi.org/10.1016/j.jchf.2020.04.010.
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    • Schwartz, Fides Regina, Tina Tailor, Jeffrey G. Gaca, Todd Kiefer, Kevin Harrison, G Chad Hughes, Juan-Carlos Ramirez-Giraldo, Daniele Marin, and Lynne M. Hurwitz. “Impact of dual energy cardiac CT for metal artefact reduction post aortic valve replacement.” Eur J Radiol 129 (August 2020): 109135. https://doi.org/10.1016/j.ejrad.2020.109135.
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    • Pineda, Andrés M., Jennifer Rymer, Alice Wang, Adam Z. Banks, Lynne H. Koweek, Ryan Plichta, Adam Williams, et al. “Transcatheter aortic valve replacement for patients with severe bicuspid aortic stenosis.” Am Heart J 224 (June 2020): 105–12. https://doi.org/10.1016/j.ahj.2020.02.003.
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    • Chung, Matthew J., Asvin M. Ganapathi, Amit N. Vora, Jacob N. Schroder, Todd L. Kiefer, and G Chad Hughes. “Valve-in-Ring Transcatheter Aortic Valve Replacement After Left Ventricular Assist Device Therapy.” Ann Thorac Surg 109, no. 3 (March 2020): e163–65. https://doi.org/10.1016/j.athoracsur.2019.06.094.
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    • Banks, Adam, Jeff Gaca, and Todd Kiefer. “Review of alternative access in transcatheter aortic valve replacement.” Cardiovasc Diagn Ther 10, no. 1 (February 2020): 72–82. https://doi.org/10.21037/cdt.2019.10.01.
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    • Pineda, Andrés M., Jennifer Rymer, Alice Wang, Lynne H. Koweek, Adam Williams, Todd Kiefer, Andrew Wang, Jeffrey Gaca, G Chad Hughes, and J Kevin Harrison. “Trends and Outcomes of Alternative-Access Transcatheter Aortic Valve Replacement.” J Invasive Cardiol 31, no. 7 (July 2019): E184–91.
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    • Fudim, Marat, Arun Ganesh, Cindy Green, W Schuyler Jones, Michael A. Blazing, Adam D. DeVore, G Michael Felker, et al. “Splanchnic nerve block for decompensated chronic heart failure: splanchnic-HF.” Eur Heart J 39, no. 48 (December 21, 2018): 4255–56. https://doi.org/10.1093/eurheartj/ehy682.
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    • Inohara, Taku, Pratik Manandhar, Andrzej S. Kosinski, Roland A. Matsouaka, Shun Kohsaka, Robert J. Mentz, Vinod H. Thourani, et al. “Association of Renin-Angiotensin Inhibitor Treatment With Mortality and Heart Failure Readmission in Patients With Transcatheter Aortic Valve Replacement.” Jama 320, no. 21 (December 4, 2018): 2231–41. https://doi.org/10.1001/jama.2018.18077.
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    • Pineda, Andrés M., and Todd L. Kiefer. “Asymptomatic Severe Aortic Valve Stenosis-When to Intervene: a Review of the Literature, Current Trials, and Guidelines.” Curr Cardiol Rep 20, no. 12 (October 11, 2018): 129. https://doi.org/10.1007/s11886-018-1072-x.
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    • Sherwood, Matthew W., and Todd L. Kiefer. “Challenges in Aortic Valve Stenosis: Low-Flow States Diagnosis, Management, and a Review of the Current Literature.” Curr Cardiol Rep 19, no. 12 (October 30, 2017): 130. https://doi.org/10.1007/s11886-017-0941-z.
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    • Kochar, Ajar, and Todd Kiefer. “Coronary Artery Anomalies: When You Need to Worry.” Curr Cardiol Rep 19, no. 5 (May 2017): 39. https://doi.org/10.1007/s11886-017-0854-x.
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    • Kiefer, Todd L., John Vavalle, Lynne M. Hurwitz, G Chad Hughes, and J Kevin Harrison. “Resolution of severe hemolysis and paravalvular aortic regurgitation employing an Amplatzer Vascular Plug 4: the importance of detailed pre-procedural planning using CT angiography.” Cardiovasc Interv Ther 32, no. 1 (January 2017): 48–52. https://doi.org/10.1007/s12928-015-0363-z.
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    • Klein, Michael R., Todd L. Kiefer, and Eric J. Velazquez. “Platypnea-Orthodeoxia Syndrome: To Shunt or Not to Shunt, That is the Question.” Tex Heart Inst J 43, no. 3 (June 2016): 264–66. https://doi.org/10.14503/THIJ-15-5280.
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    • Vemulapalli, Sreekanth, Lynne M. Hurwitz Koweek, Todd L. Kiefer, Kevin P. Jackson, and Jonathan P. Piccini. “Left atrial appendage to great cardiac vein fistula complicating watchman left atrial appendage closure.” Eur Heart J 37, no. 20 (May 21, 2016): 1602. https://doi.org/10.1093/eurheartj/ehv609.
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    • Wang, Hanghang, Jennifer M. Hanna, Asvin Ganapathi, Jeffrey E. Keenan, Lynne M. Hurwitz, John P. Vavalle, Todd L. Kiefer, Andrew Wang, J Kevin Harrison, and G Chad Hughes. “Comparison of aortic annulus size by transesophageal echocardiography and computed tomography angiography with direct surgical measurement.” Am J Cardiol 115, no. 11 (June 1, 2015): 1568–73. https://doi.org/10.1016/j.amjcard.2015.02.060.
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    • Walker, Wendy L., Daniel T. Boll, Juliana M. Bueno, Todd L. Kiefer, John P. Vavalle, Jeffrey G. Gaca, J Kevin Harrison, G Chad Hughes, Andrew Wang, and Lynne M. Hurwitz. “Assessment of single-bolus contrast administration technique using hybrid dual-source ECG-gated thoracic and dual-source non-ECG-gated high-pitch abdominopelvic CT acquisitions for procedural planning before transcatheter aortic valve replacement.” J Comput Assist Tomogr 39, no. 2 (2015): 207–12. https://doi.org/10.1097/RCT.0000000000000194.
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    • Kiefer, Todd L., Andrew Wang, and J Kevin Harrison. “Invasive hemodynamic evaluation in patients with mechanical aortic valves. Catheterization and cardiovascular interventions: official journal of the society for cardiac angiography & interventions 2013.” Catheter Cardiovasc Interv 84, no. 5 (November 1, 2014): 853–54. https://doi.org/10.1002/ccd.25067.
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    • Vora, Amit N., Thomas Gehrig, Thomas M. Bashore, and Todd L. Kiefer. “Treatment of mechanical aortic valve thrombosis with heparin and eptifibatide.” J Thromb Thrombolysis 38, no. 1 (July 2014): 73–77. https://doi.org/10.1007/s11239-014-1055-8.
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    • Vavalle, John P., Todd L. Kiefer, Carmelo A. Milano, J Kevin Harrison, and G Chad Hughes. “Transcatheter aortic valve replacement performed via left ventricular assist device inflow cannula.” Circ Heart Fail 7, no. 3 (May 2014): 544–46. https://doi.org/10.1161/CIRCHEARTFAILURE.114.001232.
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    • Rohrhoff, N., J. P. Vavalle, S. Halim, T. L. Kiefer, and J. K. Harrison. “Current status of percutaneous PFO closure.” Curr Cardiol Rep 16, no. 5 (May 2014): 477. https://doi.org/10.1007/s11886-014-0477-4.
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    • Kiefer, Todd L., John P. Vavalle, Adam Devore, Chetan B. Patel, Joseph Rogers, Carmelo Milano, Thomas R. Gehrig, and J Kevin Harrison. “Ascending aorta to main pulmonary artery fistula following orthotopic heart transplantation: successful percutaneous closure employing an Amplatzer Duct Occluder.” Jacc Cardiovasc Interv 7, no. 3 (March 2014): e25–27. https://doi.org/10.1016/j.jcin.2013.07.015.
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    • Schlendorf, Kelly, Chetan B. Patel, Thomas Gehrig, Todd L. Kiefer, G Michael Felker, Adrian F. Hernandez, Laura J. Blue, Carmelo A. Milano, and Joseph G. Rogers. “Thrombolytic therapy for thrombosis of continuous flow ventricular assist devices.” J Card Fail 20, no. 2 (February 2014): 91–97. https://doi.org/10.1016/j.cardfail.2013.12.011.
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    • Kiefer, Todd L., G Chad Hughes, Jeffrey Chad Johnson, and J Kevin Harrison. “Aortic subannular left ventricular aneurysm: a rare and surgically correctable cause of angina.” Ann Thorac Surg 97, no. 1 (January 2014): 313–15. https://doi.org/10.1016/j.athoracsur.2013.04.130.
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    • Ong, Daniel S., Robert A. Aertker, Alexandra N. Clark, Todd Kiefer, G Chad Hughes, J Kevin Harrison, and Thomas M. Bashore. “Radiation-associated valvular heart disease.” J Heart Valve Dis 22, no. 6 (November 2013): 883–92.
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    • Kiefer, Todd L., John Vavalle, Sharif Halim, Prashant Kaul, J Larry Klein, Lynne H. Hurwitz, Jeffrey G. Gaca, and J Kevin Harrison. “Anterograde percutaneous coronary-cameral fistula closure employing a guide-in-guide technique.” Jacc Cardiovasc Interv 6, no. 10 (October 2013): 1105–7. https://doi.org/10.1016/j.jcin.2013.03.023.
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    • Kiefer, Todd L., Andrew Wang, and J Kevin Harrison. “Invasive hemodynamic evaluation in patients with mechanical aortic valves.” Catheter Cardiovasc Interv 82, no. 1 (July 1, 2013): 43–50. https://doi.org/10.1002/ccd.24738.
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    • Halim, Sharif A., Todd L. Kiefer, G Chad Hughes, Lynne M. Hurwitz, and J Kevin Harrison. “Transcatheter aortic valve replacement: an update.” Curr Cardiol Rep 15, no. 6 (June 2013): 367. https://doi.org/10.1007/s11886-013-0367-1.
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    • Kiefer, Todd L., Anna Lisa Crowley, James Jaggers, and J Kevin Harrison. “Coronary arteriovenous fistulae: the complexity of coronary artery-to-coronary sinus connections.” Tex Heart Inst J 39, no. 2 (2012): 218–22.
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    • Kiefer, Todd L., and Thomas M. Bashore. “Infective endocarditis: a comprehensive overview.” Rev Cardiovasc Med 13, no. 2–3 (2012): e105–20. https://doi.org/10.3909/ricm0633.
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    • Patel, Sanjay, Todd L. Kiefer, Aijaz Ahmed, Ziad A. Ali, Jennifer A. Tremmel, David P. Lee, Alan C. Yeung, and William F. Fearon. “Comparison of the frequency of coronary artery disease in alcohol-related versus non-alcohol-related endstage liver disease.” Am J Cardiol 108, no. 11 (December 1, 2011): 1552–55. https://doi.org/10.1016/j.amjcard.2011.07.013.
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    • Kiefer, Todd L., Andrew Wang, G Chad Hughes, and Thomas M. Bashore. “Management of patients with bicuspid aortic valve disease.” Curr Treat Options Cardiovasc Med 13, no. 6 (December 2011): 489–505. https://doi.org/10.1007/s11936-011-0152-7.
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    • Kiefer, Todd, Lawrence Park, Christophe Tribouilloy, Claudia Cortes, Roberta Casillo, Vivian Chu, Francois Delahaye, et al. “Association between valvular surgery and mortality among patients with infective endocarditis complicated by heart failure.” Jama 306, no. 20 (November 23, 2011): 2239–47. https://doi.org/10.1001/jama.2011.1701.
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    • Kiefer, Todd L., and Thomas M. Bashore. “Pulmonary hypertension related to left-sided cardiac pathology.” Pulm Med 2011 (2011): 381787. https://doi.org/10.1155/2011/381787.
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    • Kiefer, Todd L., and Richard C. Becker. “Inhibitors of platelet adhesion.” Circulation 120, no. 24 (December 15, 2009): 2488–95. https://doi.org/10.1161/CIRCULATIONAHA.109.886895.
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    • Melancon, K., Q. Cheng, T. L. Kiefer, J. Dai, L. Lai, C. Dong, L. Yuan, et al. “Regression of NMU-induced mammary tumors with the combination of melatonin and 9-cis-retinoic acid.” Cancer Lett 227, no. 1 (September 8, 2005): 39–48. https://doi.org/10.1016/j.canlet.2005.01.005.
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    • Kiefer, Todd L., Ling Lai, Lin Yuan, Chunmin Dong, Matthew E. Burow, and Steven M. Hill. “Differential regulation of estrogen receptor alpha, glucocorticoid receptor and retinoic acid receptor alpha transcriptional activity by melatonin is mediated via different G proteins.” J Pineal Res 38, no. 4 (May 2005): 231–39. https://doi.org/10.1111/j.1600-079X.2004.00198.x.
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    • Collins, A., L. Yuan, T. L. Kiefer, Q. Cheng, L. Lai, and S. M. Hill. “Overexpression of the MT1 melatonin receptor in MCF-7 human breast cancer cells inhibits mammary tumor formation in nude mice.” Cancer Lett 189, no. 1 (January 10, 2003): 49–57. https://doi.org/10.1016/s0304-3835(02)00502-5.
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    • Ram, P. T., J. Dai, L. Yuan, C. Dong, T. L. Kiefer, L. Lai, and S. M. Hill. “Involvement of the mt1 melatonin receptor in human breast cancer.” Cancer Lett 179, no. 2 (May 28, 2002): 141–50. https://doi.org/10.1016/s0304-3835(01)00873-4.
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    • Nowfar, S., S. R. Teplitzky, K. Melancon, T. L. Kiefer, Q. Cheng, P. D. Dwived, E. D. Bischoff, et al. “Tumor prevention by 9-cis-retinoic acid in the N-nitroso-N-methylurea model of mammary carcinogenesis is potentiated by the pineal hormone melatonin.” Breast Cancer Res Treat 72, no. 1 (March 2002): 33–43. https://doi.org/10.1023/a:1014912919470.
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    • Kiefer, T., P. T. Ram, L. Yuan, and S. M. Hill. “Melatonin inhibits estrogen receptor transactivation and cAMP levels in breast cancer cells.” Breast Cancer Res Treat 71, no. 1 (January 2002): 37–45. https://doi.org/10.1023/a:1013301408464.
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    • Teplitzky, S. R., T. L. Kiefer, Q. Cheng, P. D. Dwivedi, K. Moroz, L. Myers, M. B. Anderson, et al. “Chemoprevention of NMU-induced rat mammary carcinoma with the combination of melatonin and 9-cis-retinoic acid.” Cancer Lett 168, no. 2 (July 26, 2001): 155–63. https://doi.org/10.1016/s0304-3835(01)00548-1.
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    • Ram, P. T., L. Yuan, J. Dai, T. Kiefer, D. M. Klotz, L. L. Spriggs, and S. M. Hill. “Differential responsiveness of MCF-7 human breast cancer cell line stocks to the pineal hormone, melatonin.” J Pineal Res 28, no. 4 (May 2000): 210–18. https://doi.org/10.1034/j.1600-079x.2000.280403.x.
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    • Cohn, C. S., J. A. Sullivan, T. Kiefer, and S. M. Hill. “Identification of an enhancer element in the estrogen receptor upstream region: implications for regulation of ER transcription in breast cancer.” Mol Cell Endocrinol 158, no. 1–2 (December 20, 1999): 25–36. https://doi.org/10.1016/s0303-7207(99)00187-2.
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    • Hill, S. M., S. Teplitzky, P. T. Ram, T. Kiefer, D. E. Blask, L. L. Spriggs, and K. M. Eck. “Melatonin synergizes with retinoic acid in the prevention and regression of breast cancer.” Adv Exp Med Biol 460 (1999): 345–62. https://doi.org/10.1007/0-306-46814-x_39.
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    • Ram, P. T., T. Kiefer, M. Silverman, Y. Song, G. M. Brown, and S. M. Hill. “Estrogen receptor transactivation in MCF-7 breast cancer cells by melatonin and growth factors.” Mol Cell Endocrinol 141, no. 1–2 (June 25, 1998): 53–64. https://doi.org/10.1016/s0303-7207(98)00095-1.
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  • Book Sections

    • Kiefer, T. L., and A. Wang. “Infective endocarditis.” In Evidence-Based Cardiology Consult, 9781447144410:71–78, 2014. https://doi.org/10.1007/978-1-4471-4441-0_6.
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    • Kiefer, T., and M. V. Podgoreanu. “Cardiac receptors.” In Core Topics in Cardiac Anesthesia, Second Edition, 39–47, 2012. https://doi.org/10.1017/CBO9780511979095.013.
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  • Other Articles

    • Kiefer, Todd L., Sharif Halim, Andrew Wang, J. Kevin Harrison, Jeffrey Gaca, and G Chad Hughes. “Fluoroscopic characterization of surgical bioprosthetic heart valves.” Catheter Cardiovasc Interv, June 2015. https://doi.org/10.1002/ccd.25904.
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  • Conference Papers

    • Sherwood, Matthew W., Sreekanth Vemulapalli, Amit N. Vora, David D. Dai, Sharif Halim, Todd L. Kiefer, G Charles Hughes, J Kevin Harrison, and Eric D. Peterson. “National Variation in Post-tavr Antithrombotic Therapy Utilization in Patients With Atrial Fibrillation: Insights From the Sts/acc Tvt Registry (R).” In Circulation, Vol. 132. LIPPINCOTT WILLIAMS & WILKINS, 2015.
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