Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Fellowship, Cardiovascular Medicine, Duke University School of Medicine 2007 - 2011
  • Resident, Internal Medicine, Stanford University School of Medicine 2005 - 2007
  • Intern, Internal Medicine, Stanford University School of Medicine 2004 - 2005
  • M.D., Louisiana State University 2004
  • Ph.D., Tulane University 2001
  • B.S., Louisiana State University 1996
• 

  Duke Appointment History

  • Assistant Professor of Medicine, Medicine, Cardiology, Medicine 2012 - 2018
• Research
• 

  Selected Grants

  • PORTICO awarded by St. Jude Medical Inc. 2014 - 2022
• Publications & Artistic Works
• 

  Selected Publications

  • Book Sections

    • Kiefer, TL, Wang, A, Kiefer, TL, and Wang, A. "Infective endocarditisInfective endocarditis (PublishedPublished)." In Evidence-Based Cardiology Consult, 71-78. November 1, 2014.  Full Text
    • Kiefer, T, and Podgoreanu, MV. "Cardiac receptors." In Core Topics in Cardiac Anesthesia, Second Edition, 39-47. January 1, 2012.  Full Text

  • Conference Papers

    • Sherwood, MW, Vemulapalli, S, Vora, AN, Dai, DD, Halim, S, Kiefer, TL, Hughes, GC, Harrison, JK, and Peterson, ED. "National Variation in Post-tavr Antithrombotic Therapy Utilization in Patients With Atrial Fibrillation: Insights From the Sts/acc Tvt Registry (R)." LIPPINCOTT WILLIAMS & WILKINS, November 10, 2015.  Link to Item

  • Journal Articles

    • Sherwood, MW, and Kiefer, TL. "Challenges in Aortic Valve Stenosis: Low-Flow States Diagnosis, Management, and a Review of the Current Literature." Current cardiology reports 19, no. 12 (October 30, 2017): 130-. (Review)  Full Text
    • Kochar, A, and Kiefer, T. "Coronary Artery Anomalies: When You Need to Worry." Current cardiology reports 19, no. 5 (May 2017): 39-. (Review)  Full Text
    • Kiefer, TL, Vavalle, J, Hurwitz, LM, Hughes, GC, and Harrison, JK. "Resolution of severe hemolysis and paravalvular aortic regurgitation employing an Amplatzer Vascular Plug 4: the importance of detailed pre-procedural planning using CT angiography." Cardiovascular intervention and therapeutics 32, no. 1 (January 2017): 48-52.  Full Text
    • Klein, MR, Kiefer, TL, and Velazquez, EJ. "Platypnea-Orthodeoxia Syndrome: To Shunt or Not to Shunt, That is the Question." Texas Heart Institute Journal 43, no. 3 (June 2016): 264-266. (Review)  Full Text
    • Vemulapalli, S, Hurwitz Koweek, LM, Kiefer, TL, Jackson, KP, and Piccini, JP. "Left atrial appendage to great cardiac vein fistula complicating watchman left atrial appendage closure." European heart journal 37, no. 20 (May 2016): 1602-.  Full Text
    • Wang, H, Hanna, JM, Ganapathi, A, Keenan, JE, Hurwitz, LM, Vavalle, JP, Kiefer, TL, Wang, A, Harrison, JK, and Hughes, GC. "Comparison of aortic annulus size by transesophageal echocardiography and computed tomography angiography with direct surgical measurement." The American journal of cardiology 115, no. 11 (June 2015): 1568-1573.  Full Text
    • Walker, WL, Boll, DT, Bueno, JM, Kiefer, TL, Vavalle, JP, Gaca, JG, Harrison, JK, Hughes, GC, Wang, A, and Hurwitz, LM. "Assessment of single-bolus contrast administration technique using hybrid dual-source ECG-gated thoracic and dual-source non-ECG-gated high-pitch abdominopelvic CT acquisitions for procedural planning before transcatheter aortic valve replacement." Journal of computer assisted tomography 39, no. 2 (March 2015): 207-212.  Full Text
    • Walker, WL, Boll, DT, Bueno, JM, Kiefer, TL, Vavalle, JP, Gaca, JG, Harrison, JK, Hughes, GC, Wang, A, and Hurwitz, LM. "Assessment of single-bolus contrast administration technique using hybrid dual-source ECG-gated thoracic and dual-source non-ECG-gated high-pitch abdominopelvic CT acquisitions for procedural planning before transcatheter aortic valve replacement." Journal of Computer Assisted Tomography 39, no. 2 (January 1, 2015): 207-212.  Full Text
    • Vora, AN, Gehrig, T, Bashore, TM, and Kiefer, TL. "Treatment of mechanical aortic valve thrombosis with heparin and eptifibatide." Journal of thrombosis and thrombolysis 38, no. 1 (July 2014): 73-77.  Full Text
    • Rohrhoff, N, Vavalle, JP, Halim, S, Kiefer, TL, and Harrison, JK. "Current status of percutaneous PFO closure." Current cardiology reports 16, no. 5 (May 2014): 477-. (Review)  Full Text
    • Vavalle, JP, Kiefer, TL, Milano, CA, Harrison, JK, and Hughes, GC. "Transcatheter aortic valve replacement performed via left ventricular assist device inflow cannula." Circulation. Heart Failure 7, no. 3 (May 2014): 544-546.  Full Text
    • Kiefer, TL, Vavalle, JP, Devore, A, Patel, CB, Rogers, J, Milano, C, Gehrig, TR, and Harrison, JK. "Ascending aorta to main pulmonary artery fistula following orthotopic heart transplantation: successful percutaneous closure employing an Amplatzer Duct Occluder." JACC. Cardiovascular interventions 7, no. 3 (March 2014): e25-e27.  Full Text
    • Schlendorf, K, Patel, CB, Gehrig, T, Kiefer, TL, Felker, GM, Hernandez, AF, Blue, LJ, Milano, CA, and Rogers, JG. "Thrombolytic therapy for thrombosis of continuous flow ventricular assist devices." Journal of Cardiac Failure 20, no. 2 (February 2014): 91-97.  Full Text
    • Kiefer, TL, Hughes, GC, Johnson, JC, and Harrison, JK. "Aortic subannular left ventricular aneurysm: a rare and surgically correctable cause of angina." Ann Thorac Surg 97, no. 1 (January 2014): 313-315.  Full Text  Link to Item
    • Kiefer, TL, Wang, A, and Harrison, JK. "Letter to the editor." Catheterization and Cardiovascular Interventions 84, no. 5 (2014): 853-854.  Full Text
    • Rohrhoff, N, Vavalle, JP, Halim, S, Kiefer, TL, and Harrison, JK. "Current status of percutaneous PFO closure." Current Cardiology Reports 16, no. 5 (January 1, 2014). (Review)  Full Text
    • Vora, AN, Gehrig, T, Bashore, TM, and Kiefer, TL. "Treatment of mechanical aortic valve thrombosis with heparin and eptifibatide." Journal of Thrombosis and Thrombolysis 38, no. 1 (January 1, 2014): 73-77.  Full Text
    • Ong, DS, Aertker, RA, Clark, AN, Kiefer, T, Hughes, GC, Harrison, JK, and Bashore, TM. "Radiation-associated valvular heart disease." The Journal of Heart Valve Disease 22, no. 6 (November 2013): 883-892. (Review)
    • Kiefer, TL, Vavalle, J, Halim, S, Kaul, P, Klein, JL, Hurwitz, LH, Gaca, JG, and Harrison, JK. "Anterograde percutaneous coronary-cameral fistula closure employing a guide-in-guide technique." JACC Cardiovasc Interv 6, no. 10 (October 2013): 1105-1107.  Full Text  Link to Item
    • Kiefer, TL, Wang, A, and Harrison, JK. "Invasive hemodynamic evaluation in patients with mechanical aortic valves." Catheter Cardiovasc Interv 82, no. 1 (July 1, 2013): 43-50.  Full Text  Link to Item
    • Halim, SA, Kiefer, TL, Hughes, GC, Hurwitz, LM, and Harrison, JK. "Transcatheter aortic valve replacement: an update." Curr Cardiol Rep 15, no. 6 (June 2013): 367-. (Review)  Full Text  Link to Item
    • Kiefer, TL, Wang, A, and Harrison, JK. "Invasive hemodynamic evaluation in patients with mechanical aortic valves. Catheterization and cardiovascular interventions: Official Journal of the Society for Cardiac Angiography & Interventions 2013." Catheterization and Cardiovascular Interventions (2013).  Full Text
    • Kiefer, TL, Wang, A, and Harrison, JK. "Invasive hemodynamic evaluation in patients with mechanical aortic valves." Catheterization and Cardiovascular Interventions 82, no. 1 (2013): 43-50.  Full Text
    • Kiefer, TL, Crowley, AL, Jaggers, J, and Harrison, JK. "Coronary arteriovenous fistulae: the complexity of coronary artery-to-coronary sinus connections." Tex Heart Inst J 39, no. 2 (2012): 218-222.  Link to Item
    • Kiefer, TL, and Bashore, TM. "Infective endocarditis: a comprehensive overview." Rev Cardiovasc Med 13, no. 2-3 (2012): e105-e120. (Review)  Link to Item
    • Kiefer, TL, Wang, A, Hughes, GC, and Bashore, TM. "Management of patients with bicuspid aortic valve disease." Curr Treat Options Cardiovasc Med 13, no. 6 (December 2011): 489-505.  Full Text  Link to Item
    • Kiefer, T, Park, L, Tribouilloy, C, Cortes, C, Casillo, R, Chu, V, Delahaye, F, Durante-Mangoni, E, Edathodu, J, Falces, C, Logar, M, Miró, JM, Naber, C, Tripodi, MF, Murdoch, DR, Moreillon, P, Utili, R, and Wang, A. "Association between valvular surgery and mortality among patients with infective endocarditis complicated by heart failure." Jama 306, no. 20 (November 2011): 2239-2247.  Full Text
    • Kiefer, TL, and Bashore, TM. "Pulmonary hypertension related to left-sided cardiac pathology." Pulm Med 2011 (2011): 381787-.  Full Text  Link to Item
    • Patel, S, Kiefer, TL, Ahmed, A, Ali, ZA, Tremmel, JA, Lee, DP, Yeung, AC, and Fearon, WF. "Comparison of the frequency of coronary artery disease in alcohol-related versus non-alcohol-related endstage liver disease." American Journal of Cardiology 108, no. 11 (2011): 1552-1555.  Full Text
    • Kiefer, TL, and Becker, RC. "Inhibitors of platelet adhesion." Circulation 120, no. 24 (December 15, 2009): 2488-2495. (Review)  Full Text  Link to Item
    • Kiefer, TL, Lai, L, Yuan, L, Dong, C, Burow, ME, and Hill, SM. "Differential regulation of estrogen receptor alpha, glucocorticoid receptor and retinoic acid receptor alpha transcriptional activity by melatonin is mediated via different G proteins." Journal of Pineal Research 38, no. 4 (2005): 231-239.  Full Text
    • Melancon, K, Cheng, Q, Kiefer, TL, Dai, J, Lai, L, Dong, C, Yuan, L, Collins, A, Thiyagarajah, A, Long, S, and Hill, SM. "Regression of NMU-induced mammary tumors with the combination of melatonin and 9-cis-retinoic acid." Cancer Letters 227, no. 1 (2005): 39-48.  Full Text
    • Collins, A, Yuan, L, Kiefer, TL, Cheng, Q, Lai, L, and Hill, SM. "Overexpression of the MT1 melatonin receptor in MCF-7 human breast cancer cells inhibits mammary tumor formation in nude mice." Cancer Letters 189, no. 1 (2003): 49-57.  Full Text
    • Kiefer, T, Ram, PT, Yuan, L, and Hill, SM. "Melatonin inhibits estrogen receptor transactivation and cAMP levels in breast cancer cells." Breast Cancer Research and Treatment 71, no. 1 (2002): 37-45.  Full Text
    • Nowfar, S, Teplitzky, SR, Melancon, K, Kiefer, TL, Cheng, Q, Dwivedi, PD, Bischoff, ED, Moroz, K, Anderson, MB, Dai, J, Lai, L, Yuan, L, and Hill, SM. "Tumor prevention by 9-cis-retinoic acid in the N-nitroso-N-methylurea model of mammary carcinogenesis is potentiated by the pineal hormone melatonin." Breast Cancer Research and Treatment 72, no. 1 (2002): 33-43.  Full Text
    • Ram, PT, Dai, J, Yuan, L, Dong, C, Kiefer, TL, Lai, L, and Hill, SM. "Involvement of the mt1 melatonin receptor in human breast cancer." Cancer Letters 179, no. 2 (2002): 141-150.  Full Text
    • Teplitzky, SR, Kiefer, TL, Cheng, Q, Dwivedi, PD, Moroz, K, Myers, L, Anderson, MB, Collins, A, Dai, J, Yuan, L, Spriggs, LL, Blask, DE, and Hill, SM. "Chemoprevention of NMU-induced rat mammary carcinoma with the combination of melatonin and 9-cis-retinoic acid." Cancer Letters 168, no. 2 (2001): 155-163.  Full Text
    • Ram, PT, Yuan, L, Dai, J, Kiefer, T, Klotz, DM, Spriggs, LL, and Hill, SM. "Differential responsiveness of MCF-7 human breast cancer cell line stocks to the pineal hormone, melatonin." Journal of Pineal Research 28, no. 4 (2000): 210-218.
    • Cohn, CS, Sullivan, JA, Kiefer, T, and Hill, SM. "Identification of an enhancer element in the estrogen receptor upstream region: Implications for regulation of ER transcription in breast cancer." Molecular and Cellular Endocrinology 158, no. 1-2 (1999): 25-36.  Full Text
    • Hill, SM, Teplitzky, S, Ram, PT, Kiefer, T, Blask, DE, Spriggs, LL, and Eck, KM. "Melatonin synergizes with retinoic acid in the prevention and regression of breast cancer." Advances in Experimental Medicine and Biology 460 (1999): 345-362.
    • Ram, PT, Kiefer, T, Silverman, M, Song, Y, Brown, GM, and Hill, SM. "Estrogen receptor transactivation in MCF-7 breast cancer cells by melatonin and growth factors." Molecular and Cellular Endocrinology 141, no. 1-2 (1998): 53-64.  Full Text

  • Other Articles

    • Kiefer, TL, Halim, S, Wang, A, Kevin Harrison, J, Gaca, J, and Hughes, GC. "Fluoroscopic characterization of surgical bioprosthetic heart valves." Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 85, no. 7 (June 2015): 1274-1276. (Letter)  Full Text

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